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Mingjie Zhao edited this page Sep 4, 2021 · 3 revisions
  • 3D Slicer Modules: individual tools in 3D Slicer. AutomaticContour and ErosionDetection are two separate modules in this 3D Slicer extension.
  • Periosteal Mask: a binary mask that marks the periosteal bone surface and indicates where the bone surface should be if there were no bone erosions.
  • Endosteal Mask: a binary mask that marks the endosteal bone surface and shows the inner surface of the cortex.
  • Seed Point: a point on an image to help with image processing. The erosion analysis in this 3D Slicer extension is not completely automatic as it requires manually selected seed points as input.
  • Voxel Intensity: the brightness of each point in a three-dimensional image. Voxels with different intensities may represent different anatomical structures.
  • Dilate/Erode Operations: imaging filters that inflate/deflate the objects in an image by a certain distance. Those operations are used in the image segmentation pipelines in this 3D Slicer extension.
  • Bone Erosion: a cortical break that extends over at least two slices on two perpendicular planes on HR-pQCT, and is non-linear in shape (to differentiate from a physiological vascular channel that is linear in shape) [1]. Below is an example [1].
  • Cortical Break: a clear disruption of the cortex, seen on two consecutive slices on two perpendicular planes on HR-pQCT. Erosions are a subset of cortical breaks. It is difficult to automatically identify erosions, so the toolkit aims to automatically identify cortical breaks instead, based on an automated algorithm [2].

[1] Barnabe C, Toepfer D, Marotte H, Hauge EM, Scharmga A, Kocijan R, Kraus S, Boutroy S, Schett G, Keller KK, et al. Definition for rheumatoid arthritis erosions imaged with high resolution peripheral quantitative computed tomography and interreader reliability for detection and measurement. J Rheumatol (2016) 43:1935–1940. doi:10.3899/jrheum.160648

[2] Peters M, Scharmga A, de Jong J, van Tubergen A, Geusens P, Arts JJ, Loeffen D, Weijers R, van Reitbergen B, van den Bergh J. An automated algorithm for the detection of cortical interruptions on high resolution peripheral quantitative computed tomography images of finger joints. PLOS ONE (2017) 12:e0179138. doi:10.1371/journal.pone.0179138

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