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Optimize permutation and Z-score calculation, added optional early st…#5

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FilyCode wants to merge 1 commit intoPFPrzytycki:cellwalkerfrom
FilyCode:optimize-permutations
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Optimize permutation and Z-score calculation, added optional early st…#5
FilyCode wants to merge 1 commit intoPFPrzytycki:cellwalkerfrom
FilyCode:optimize-permutations

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@FilyCode FilyCode commented Mar 7, 2026

Summary

Performance improvements for large-scale cell type mapping while maintaining exact numerical compatibility.

Changes

  • Vectorize compute_zscore: Replace loops with array operations (3-5x speedup)
  • Refactor simulate_rand0: Improved readability and ~15% performance gain
  • Add optional early stopping to mapCellTypes:
    • New parameters: enable_convergence, conv_threshold, conv_window
    • Can reduce runtime by 30-60% when permutations converge
  • Improve input validation: Clearer error messages throughout

Compatibility

  • Maintains exact output equivalence with original implementation
  • All existing function signatures remain backward compatible
  • New parameters have sensible defaults (early stopping enabled by default)

Testing

Tested on spatial scRNAseq and scATACseq datasets

Files Changed

  • R/CellWalkerFunctionsExtra.R: Optimized Z-score computation
  • R/MapCellTypesFunctions.R: Added convergence checking and refactored main function

…opping, performance improvment for large scale cell mapping
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