Microstructural asymmetry in the human cortex

This repo is for documentation of the work "Microstructural asymmetry in the human cortex"

Paper: https://www.nature.com/articles/s41467-024-54243-9
It includes 5 visualization ipython notebooks, 2 built-in python scripts, and 1 bash script.

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$ BASH

run_solar.sh
This script helps compute twin-based heritability using SOLAR (https://solar-eclipse-genetics.org/)

$ built-in python scripts

func_plot.py and func_stats.py help plot brain surfaces and bar charts, and statistics about peemutation using variogram and cohen's d, FDR correction, etc.

$ ipython notebooks

• Vis_BigBrain.ipynb includes BigBrain main and supplementary figures: post-mortem cytoarchitectural asymmetry

• Vis_HCP.ipynb includes main and supplementary results and figures using Human Connectome Project (HCP) data: in vivo T1w/T2w asymmetry, sex and age effects, heritability, and relation to functional connectome

• Vis_CCA.ipynb includes behavioral relevence results and figures using canonical correlation analysis (CCA) in HCP: language and mental health association

• Vis_MICs.ipynb includes the supplementary figure using MICA-MICs sample (N=50): in vivo quantitative T1 asymmetry

• Vis_NSPN.ipynb includes the supplementary figure using NSPN sample (N=286): in vivo magnetization transfer (MT) asymmetry

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Key toolboxes

• Micapipe (https://micapipe.readthedocs.io/en/latest/)
• BigBrainWrap (https://bigbrainwarp.readthedocs.io/en/latest/)
• Brainspace (https://brainspace.readthedocs.io/en/latest/index.html)
• Brainstat (https://brainstat.readthedocs.io/en/master/)
• BrainSMASH (https://brainsmash.readthedocs.io/en/latest/)
• SOLAR (https://solar-eclipse-genetics.org/)
• Scikit-learn (https://scikit-learn.org/stable/)

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Correspondence

Bin Wan (binwan.academic@gmail.com)
Sofie L. Valk (valk@cbs.mpg.de)

Cognitive Neurogenetics (CNG) lab,
Max Planck Institute for Human Cognitive and Brain Sciences &
Institute of Neuroscience and Medicine (INM-7), Research Centre Jülich