This code implements group-conservation-weighted SDP scoring, as described in:
Sloutsky R, Naegle KM (2016) High-Resolution Identification of Specificity Determining Positions in the LacI Protein Family Using Ensembles of Sub-Sampled Alignments. PLoS ONE 11(9): e0162579.
The un-weighted version of this scoring formula was originally described in:
Capra JA and Singh M. (2008) Characterization and Prediction of Residues Determining Protein Functional Specificity. Bioinformatics, 24(13): 1473-1480, 2008.
Please cite if you use this code.
Please contact Roman Sloutsky (sloutsky at wustl.edu) with questions and bug reports.