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New option --skato-collapse-below-aac for remeta gene to collapse variants in SKATO with default 3. Now variants with AAC<3 are collapsed into a burden mask like in regenie. This significantly reduces computation time for large genes like TTN and MUC16.
New option --cohort-extract COHORT1=FILE1 COHORT2=FILE2 ... for remeta gene to specify an extract list per cohort. When this option is set, only variants in the --cohort-extract extract list for that cohort, and not in the --exclude list, will be included in gene-based tests for that cohort. This overrides the --sources and --extract arguments.
Fixed a bug in remeta compute-ref-ld where variants with AAF near 1 could have negative variance due to loss of precision when using 32-bit floating point numbers.
Fixed a bug where tabixable annotation files where not falling back to the rgi index if the tabix index was not available.
Fixed a bug where using the --chr option with unindexed --htp caused the first line to be dropped.
The output model column for PVMA of SBAT was updated from BURDEN-SBAT-META_{GENEP_GROUP} to ADD-WGR-BURDEN-SBAT-META_{GENEP_GROUP} to be consistent with other tests.
Added fallback option to compute standard errors from confidence intervals when missing from the Info column.
In remeta esma, check that the field INFO in the Info column is a valid double.
Output more informative error messages when remeta fails to parse a line from an HTP file.
Added support for 6 column allele frequency file where the sixth column is AN