This repository comprises the R and python script used for data processing, iENR Model Training and downstream analyses associated with the manuscript: "An Adaptive Feedback Model of the Transcriptional Brain Aging Clock Resolves Cell Type Heterogeneity in Aging and Neurodegeneration."
Model training was performed in Python using:
- scanpy and anndata for data handling
- scikit-learn for ElasticNet regression
- scipy and numpy for statistical analysis