Tools for dynamic dosing with mrgsolve

Poster

Simulating Adaptive Dosing Regimens from PK and PKPD Models Using mrgsolve
15th American Conference on Pharmacometrics
Poster: W-007, Wednesday November 13, 2024
PDF: docs/poster.pdf

More info on evtools in the user guide.

Content in this repository

Platelet PKPD model code and outputs

• Reference: Fukae M, Baron K, Tachibana M, Mondick J, Shimizu T. Population pharmacokinetics of total and unbound valemetostat and platelet dynamics in healthy volunteers and patients with non-Hodgkin lymphoma. CPT Pharmacometrics Syst Pharmacol. 2024; 13: 1641-1654. doi:10.1002/psp4.13201
• Main PKPD model file contains both the valemetostat PK model and the platelet dynamic model
• Code to implement platelet monitoring is a C++ header file that gets included into the PKPD model file
• A simple demonstration of invoking the platelet model with no dose adjustments; generates poster Figure 2
• The R code used to generate poster Figure 3

A vignette showing ten examples of dose regimen implementation inside your mrgsolve model

• The vignette source code is here
• The full source code for all the models can be found here