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Expand Up @@ -11,7 +11,7 @@ MICtools is an open source pipeline which combines the TIC_e and MIC_e measures
[Reshef2016]_ into a two-step procedure that allows to identify relationships of
various degrees of complexity in large datasets. TIC_e is used to perform
an efficient high throughput screening of all the possible pairwise
relationships and a permutation based appraoch is used to assess their significance.
relationships and a permutation based approach is used to assess their significance.
MIC_e is then used to rank the subset of significant associations on the bases of their strength.

**Please cite**: Davide Albanese, Samantha Riccadonna, Claudio Donati, Pietro
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