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Welcome to the DRD_2025_Project Wiki

This project was developed as part of the DNA/RNA Dynamics course at the University of Bologna (2025). It presents a reproducible, R-based pipeline for analyzing genome-wide DNA methylation data using the Illumina HumanMethylation450 BeadChip.

🔍 Overview

• 🧬 Platform: Illumina 450K BeadChip
• 💻 Language: R (≥ 4.0)
• 📂 Input: .idat files
• 📈 Output: PCA plots, volcano plots, heatmaps, and annotated reports

📌 Key Features

• Raw data preprocessing and quality control
• Group-specific normalization
• Differential methylation analysis
• Interactive and reproducible reporting (PDF + HTML)

👉 To get started, see the Installation page.