CDSMutSig is a R package containing a set of functions to map, given a protein, its coding DNA sequences, all possible amino acid substitutions as well as their corresponding DNA mutational contexts. This allows analysis of different protein-level consequences caused by different mutagenic processes.
In R:
require(devtools)
install_github("josef0731/CDSMutSig", ref = "main")
Please see this vignette for examples.
Ng JCF & Fraternali F. Protein structural consequences of DNA mutational signatures: A meta-analysis of somatic variants and deep mutational scanning data. Manuscript in preparation, 2021.