IMPORTANT! Dowser's source code has moved to https://github.com/immcantation/dowser
To update Git configuration settings use:
git config user.email "your-gh-user@email.com"
git config user.name "your-gh-user-name"
git remote set-url origin git@github.com:immcantation/dowser.git
Dowser is part of the Immcantation analysis framework for Adaptive Immune Receptor Repertoire sequencing (AIRR-seq). Dowser provides a set of tools for performing phylogenetic analysis on B cell receptor repertoires. It supports building and visualizing trees using multiple methods, and implements statistical tests for discrete trait analysis of B cell migration, differentiation, and isotype switching.
Dowser has 6 primary functions:
- Reconstruct clonal germline sequences.
- Build B cell lineage trees using multiple methods, such as maximum parsimony, maximum likelihood, and IgPhyML.
- Reconstruct intermediate sequences within lineage trees using different methods.
- Create publication-quality lineage tree plots.
- Analyze trees to detect ongoing B cell evolution over time.
- Understand B cell migration and differentiation.
Full documentation, including tutorials and vignettes: https://dowser.readthedocs.io
If you need help or have any questions, please contact the Immcantation Group.
If you have discovered a bug or have a feature request, you can open an issue using the issue tracker.
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