Mendelian Randomization Report: LTL and MS Progression

This repository hosts the interactive HTML report accompanying the following peer-reviewed publication:

Sabaie H. and Taghavi Rad A. et al.
Deciphering the bidirectional impact of leukocyte telomere length on multiple sclerosis progression:
A Mendelian randomization study.
Multiple Sclerosis and Related Disorders (2025)
DOI: https://doi.org/10.1016/j.msard.2025.106277

---

🌐 Online HTML Report

The full interactive report is available at:

🔗 https://hani-sabaie.github.io/LTL-MSP-MR/MR-Report.html

---

📄 Repository Contents

• LTL_MS_prog.html
  Final rendered HTML report containing:
  • Bidirectional two-sample Mendelian randomization analyses
  • Sensitivity, pleiotropy, and directionality tests
  • Figures and summary tables referenced in the manuscript

---

🔍 Purpose

This repository is provided to:

• Ensure transparency and reproducibility of Mendelian randomization analyses
• Offer a permanent, citable web-based supplement to the published article
• Allow interactive exploration of results beyond static figures

---

🧪 Methods Summary

• Bidirectional two-sample Mendelian randomization
• GWAS summary statistics:
  • Leukocyte telomere length (UK Biobank)
  • Multiple sclerosis progression (IMSGC)
• Primary estimator: inverse-variance weighted (IVW)
• Extensive sensitivity analyses:
  • MR-Egger, weighted median/mode
  • MR-PRESSO, RadialMR
  • MR-RAPS, MR-Lasso, MR-cML, dIVW, MBE
  • Steiger directionality tests

Full methodological details are described in the published article.

---

⚠️ Notes

• Original GWAS data are publicly available from the respective consortia.
• No individual-level data are included.