Add KLIFS kinase-ligand database processor #1488
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This adds a new source module for KLIFS (Kinase-Ligand Interaction Fingerprints and Structures), a database of curated structural data on kinase-inhibitor binding.
Changes:
New indra.sources.klifs module with API client and processor
Generates Inhibition statements from kinase-ligand co-crystallization data
Kinases grounded to HGNC/UniProt
Ligands grounded to ChEMBL/ChEBI where available
Unit tests for processor logic and API integration included
Added source to source_info.json, default_belief_probs.json, statement_presentation.py, setup.py, and README.md
Belief priors: Set to match similar drug-target databases (syst: 0.01, rand: 0.1). Open to feedback on these values.
Note: The processor assumes kinase-ligand interactions are inhibitory, which is typical for KLIFS data but not universally true. This is reflected in the rand prior.