CATH-FunFam refactoring #415
Draft
Add this suggestion to a batch that can be applied as a single commit.
This suggestion is invalid because no changes were made to the code.
Suggestions cannot be applied while the pull request is closed.
Suggestions cannot be applied while viewing a subset of changes.
Only one suggestion per line can be applied in a batch.
Add this suggestion to a batch that can be applied as a single commit.
Applying suggestions on deleted lines is not supported.
You must change the existing code in this line in order to create a valid suggestion.
Outdated suggestions cannot be applied.
This suggestion has been applied or marked resolved.
Suggestions cannot be applied from pending reviews.
Suggestions cannot be applied on multi-line comments.
Suggestions cannot be applied while the pull request is queued to merge.
Suggestion cannot be applied right now. Please check back later.
Currently, we run
hmmsearchagainst the HMM database of each CATH superfamily identified, then we runcath-resolve-hits. If two FunFam models (from two different CATH superfamilies) hit the same sequence and overlap, their matches will not be resolved bycath-resolve-hitssince they are resolved individually.This PR changes the way we search for FunFam domains. Like in InterProScan 6, we write the output of all
hmmsearchrun to a single file, then resolve this file once.