Motivation Type 2 Diabetes (T2D) is escalating to be an epidemic problem in many parts of the world $^1$ . Weight reduction for obese patients has been given as a routine advise from health care professionals. BMI >30 is the most common definition for obesity. However, does BMI affect T2D at a genetic level? That is, does BMI >30 change gene differential expression in patients with T2D vs. healthy individual?

This project attempts to elucidate the effect of BMI on differential gene expression in T2D.

Data Summary

The dataset has been previously described by Mahdi et al. , 2012 where the authors explroe the pathophysiology of T2D by analyzing the gene coexpression to investigate if their pre-defined module is associated with T2D, elevated HbA1C and reduced insulin secretion. They performed PCA to identify these eignegenes and perform a gene set enrichment in answering their biological questions. In Tang et al. , 2014, the authors performed an additive linear regression with covariates: age, sex and BMI to investigate the association betwewen yohimbine dosage and insulin secretion in 30 minutes.

References
Tabish, Syed Amin. “Is Diabetes Becoming the Biggest Epidemic of the Twenty-first Century?.” International journal of health sciences vol. 1,2 (2007): V-VIII.