TOSCA is a packege for inferring the timing in real time of clonal and subclonal somatic copy numbers (SCNA) of type 2:0, 2:1 and 2:2, and of driver events altering the mutation rate. The input data is the result of the clonal and signature deconvolution analyses performed on WGS longitudinal data.
If you use TOSCA, please cite: * Timing cancer genomics driver
events around therapy Riccardo Bergamin, Alice Antonello, Giulio
Caravagna.
devtools::install_github("caravagnalab/TOSCA")