Metasheller is a pip installable package to create metacells using SEACells quickly (and in parallel).
I've applied it to noisy scRNA data from many samples prior to running SLIDE, and to reduce the number of representative cells of a certain clonotype.
It's recommended to use a dedicated Python environment for Metasheller. Here’s a quick guide:
conda create -n metasheller-env python=3.8
conda activate metasheller-envpip install metashellerTo get started quickly, follow the example in tutorial.ipynb