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Aashutosh Boob

About Me

Hi! I’m a Data Scientist at Sarepta Therapeutics, where I develop advanced analytical methods to leverage internal and external chemistry and biological data in support of all therapeutic modalities, including RNA, gene therapy, and gene editing.

Previously, I completed my Ph.D. in the Department of Chemical and Biomolecular Engineering at the University of Illinois Urbana-Champaign, where I was advised by Dr. Huimin Zhao. In graduate school, my research primarily focused on developing computational tools to engineer functionally improved synthetic biology components and cellular factories.

I’m particularly enthusiastic about studying evolution at various levels, including regulatory elements, proteins, organelles, and strains. My career interests lie in harnessing Artificial Intelligence and Machine Learning to advance biology and healthcare. Please feel free to reach out for scientific discussions or collaborations.

Projects

Published Work:

  • PlasmidMaker is a versatile, automated, and high throughput end-to-end platform for plasmid construction. Paper, Code
  • A landing pad system for multicopy gene integration in Issatchenkia orientalis. Paper, Code
  • CRISPR-COPIES: An in silico platform for discovery of neutral integration sites for CRISPR/Cas-facilitated gene integration. Paper, Code
  • Discovery, characterization, and application of chromosomal integration sites for stable heterologous gene expression in Rhodotorula toruloides. Paper, Code
  • Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder. Paper, Code
  • Discovery, characterization, and application of chromosomal integration sites in the hyperthermophilic crenarchaeon Sulfolobus islandicus. Paper, Code

Upcoming Projects:

  • ML-guided Genetic Toolkit Design for Fungi (Coming Soon) - Code

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