1.) Summary
2.) Usage
3.) Definitions
3.1) Default Mode Circuit
3.2) Salience Circuit
3.3) Attention Circuit
3.4) Negative Affect Circuit: Sad
3.5) Negative Affect Circuit: Threat Conscious
3.6) Negative Affect Circuit: Threat Nonconscious
3.7) Positive Affect Circuit: Happy
3.8) Cognitive Control Circuit
^ Summary
This folder includes the ROI regions used in the Williams 2021 Biological Psychiatry paper:
Mapping neural circuit biotypes to symptoms and behavioral dimensions of depression and anxiety
Andrea N Goldstein-Piekarski†, Tali M Ball†, Zoe Samara‡, Brooke R Staveland‡, Arielle S. Keller‡, Scott L Fleming‡, Katherine A Grisanzio‡, Bailey Holt-Gosselin‡, Patrick Stetz‡, Jun Ma‡, & Leanne M Williams
^ Usage
Please include the following citation:
Goldstein-Piekarski A, Ball T, Samara Z, Staveland B, Keller A, Fleming S, Grisanzio K, Holt-Gosselin B, Stetz P, Ma J, & Williams L. Mapping neural circuit biotypes to symptoms and behavioral dimensions of depression and anxiety. Biological Psychiatry. 2021; doi: https://doi.org/10.1016/j.biopsych.2021.06.024
To download the files, please click here or clone the repository
^ Definitions
^ Default Mode Circuit
| Circuit Type | Condition | Task Contrast | Neurosynth Search criteria |
|---|---|---|---|
| Intrinsic | Task-free | --- | Terms = "default mode"; "resting state"; Number of studies = 516; 825 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| amPFC | 22.0 | -2, 50, -6 | Medial_amPFC_DefaultModeNetwork_n2_50_n6.nii.gz |
| AG L | 26.1 | -46, -70, 32 | Left_AG_DefaultModeNetwork_n46_n70_32.nii.gz |
| AG R | 20.6 | 50, -62, 26 | Right_AG_DefaultModeNetwork_50_n62_26.nii.gz |
| PCC | 29.8 | 0, -50, 28 | Medial_PCC_DefaultModeNetwork_0_n50_28.nii.gz |
^ Salience Circuit
| Circuit Type | Condition | Task Contrast | Neurosynth Search criteria |
|---|---|---|---|
| Intrinsic | Task-free | --- | Terms = "salience network"; "salience" Number of studies = 60; 269 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| aI L | 11.9 | -38, 14, -6 | Left_antInsula_Salience_n38_14_n6.nii.gz |
| aI R | 14.8 | 38, 18, 2 | Right_antInsula_Salience_38_18_2.nii.gz |
| Amygdala L | 6.9 | AAL | Left_Amygdala_Salience.nii.gz |
| Amygdala R | 14.7 | AAL | Right_Amygdala_Salience.nii.gz |
^ Attention Circuit
| Circuit Type | Condition | Task Contrast | Neurosynth Search criteria |
|---|---|---|---|
| Intrinsic | Task-free | --- | Terms = "frontoparietal network"; "attention" Number of studies = 1447; 79 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| msPFC | 10.4 | -2, 14, 52 | Medial_msPFC_Attention_n2_14_52.nii.gz |
| LPFC L | 13.9 | -44, 6, 32 | Left_lPFC_Attention_n44_6_32.nii.gz |
| LPFC R | 11.3 | 50, 10, 28 | Right_lPFC_Attention_50_10_28.nii.gz |
| aIPL L | 10.4 | -30, -54, 40 | Left_aIPL_Attention_n30_n54_40.nii.gz |
| aIPL R | 10.4 | 38, -56, 48 | Right_aIPL_Attention_38_n56_48.nii.gz |
| Precuneus L | 13.0 | -14, -66, 52 | Left_precuneus_Attention_n14_n66_52.nii.gz |
| Precuneus R | 11.3 | 18, -68, 52 | Right_precuneus_Attention_18_n68_52.nii.gz |
^ Negative Affect Circuit: Sad
| Circuit Type | Condition | Task Contrast | Neurosynth Search Criteria |
|---|---|---|---|
| Task-evoked | Conscious Facial Emotion Viewing | Sad vs Neutral based on standardized facial emotion stimuli | Term = "threat" Number of studies = 170 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| pgACC* | 6.3 | 6, 42, 4 | Medial_pgACC_NegativeAffect_n6_42_n4.nii.gz |
| aI L | 17.4 | -36, 20, -4 | Left_antInsula_NegativeAffect_n36_20_n4.nii.gz |
| aI R | 16.1 | 38, 22, -4 | Right_antInsula_NegativeAffect_38_22_n4.nii.gz |
| Amygdala L | 28.4 | AAL | Left_Amygdala_NegativeAffect.nii.gz |
| Amygdala R | 25.2 | AAL | Right_Amygdala_NegativeAffect.nii.gz |
^ Negative Affect Circuit: Threat Conscious
| Circuit Type | Condition | Task Contrast | Neurosynth Search Criteria |
|---|---|---|---|
| Task-evoked | Conscious Facial Emotion Viewing | Fear/Anger vs Neutral based on standardized facial emotion stimuli | Term = "threat" Number of studies = 170 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| dACC | 8.2 | 6, 22, 32 | Medial_dACC_NegativeAffect_6_22_32.nii.gz |
| Amygdala L | 28.4 | AAL | Left_Amygdala_NegativeAffect.nii.gz |
| Amygdala R | 25.2 | AAL | Right_Amygdala_NegativeAffect.nii.gz |
^ Negative Affect Circuit: Threat Nonconscious
| Circuit Type | Condition | Task Contrast | Neurosynth Search Criteria |
|---|---|---|---|
| Task-evoked | Nonconscious Facial Emotion Viewing | Fear/Anger vs Neutral based on standardized facial emotion stimuli | Term = "threat" Number of studies = 170 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| sgACC | 5.6 | 4, 26, -10 | Medial_sgACC_NegativeAffect_4_26_n10.nii.gz |
| Amygdala L | 28.4 | AAL | Left_Amygdala_NegativeAffect.nii.gz |
| Amygdala R | 25.2 | AAL | Right_Amygdala_NegativeAffect.nii.gz |
^ Positive Affect Circuit: Happy
| Circuit Type | Condition | Task Contrast | Neurosynth Search Criteria |
|---|---|---|---|
| Task-evoked | Conscious Facial Emotion Viewing | Happy vs Neutral based on standardized facial emotion stimuli | Terms = "monetary reward"; "reward" Number of studies = 84; 671 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| vMPFC | 13.1 | -2, 56, -8 | Medial_vmPFC_PositiveAffect_n2_56_n8.nii.gz |
| Striatum L | 14.0 | FSL | Left_vStriatum_PositiveAffect.nii.gz |
| Striatum R | 7.9 | FSL | Right_vStriatum_PositiveAffect.nii.gz |
^ Cognitive Control Circuit
| Circuit Type | Condition | Task Contrast | Neurosynth Search Criteria |
|---|---|---|---|
| Task-evoked | Go-NoGo task | No-Go vs. Go | Terms = "cognitive control" Number of studies = 428 Search Date = 6.4.17 |
| Region anatomy | Z Value | Template coordinates and definitions | Filename |
|---|---|---|---|
| dACC | 20.0 | 0, 18, 46 | Medial_dACC_CognitiveControl_0_18_46.nii.gz |
| DLPFC L | 20.4 | -44, 6, 32 | Left_dlPFC_CognitiveControl_n44_6_32.nii.gz |
| DLPFC R | 12.4 | 44, 34, 22 | Right_dlPFC_CognitiveControl_44_34_22.nii.gz |
*The pgACC peaks were defined by decreasing the minimum cluster distance in the 3dCluster algorithm.