Tool for exploring ligandable cysteines on >20,000 human predicted protein structures, accompanying an accessibility-based analysis of published cysteine-focused chemoproteomic datasets.
AlphaFold2 structures are directly pulled from the AlphaFold Protein Structure Database and reformatted to visualise different metrics of interest (pPSE, prediction quality/pLDDT) and highlight custom residues. Subsequent structures are displayed in an interactive visualiser.
Ligandability data from collated fragment screening datasets1,2,3,4 are also displayed when available. Fragment chemical structures can be visualised from the drop down menu.
AlpACA-DB can be found here.
Example usage below:
