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@xueweic xueweic commented Nov 22, 2025

Important update

Adding poster-filtering parameter in colocboost main function.

  • pvalue_cutoff = 1e-3: remove the colocalized outcome in CoS if p-value greater than this cutoff
  • cos_npc_cutoff = 0.2: remove the CoS with cos_npc less than this cutoff
  • npc_outcome_cutoff = 0.2: remove the colocalized outcome in CoS if npc_outcome less than this cutoff

Higher thresholds can be specified if users want to focus only on strong colocalization events. For future analysis, please refer to Tutorial: Filter colocalization events by relative strength of evidence and function get_robust_colocalization.

fix error changed last time
Add post-filtering in colocboost main function
@xueweic xueweic requested a review from gaow November 22, 2025 14:25
@gaow gaow merged commit 8265997 into StatFunGen:main Nov 22, 2025
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2 participants