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SPACEgroupX/README.md

SPACEMapX - Spatial Phylogenetic Analysis and Clonal Evolution: MAPping the lethal clone (X)

This package provides guidance for analysis of spatially resolved tissue (Visium ST), focusing on clonal dynamics derived from inferred copy number status.

Our particular goal has been identification of the "lethal clone", defined as the clone which metasises from primary cancer tissue to lymph nodes. However, this package can be used for any analysis of clonal evolution and/or somatic mosaicism in heterogeneous tissue.

If you need any assistance with running this package, please feel free to contact us via GitHub "issue" messaging

Pre-requirement

This package is based on InferCNV & SpatialInferCNV. SPACEmapX is designed as a helper package for these.

Funding

Cancer Research UK (CRUK) #C57899/A25812 "Spatial Prostate Assessment and Circulating Environment – The SPACE Study"

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