The Oncode library is a repurposing library created by the Dutch Oncode institute (https://oncodeinstitute.nl/facilities/drug-repurposing-1). This library was created based on the previously published repurposing library of the Broad Institute in Nature Medicine (https://www.nature.com/articles/nm.4306.epdf?author_access_token=lVts41U5Yg2SuJRRMDAHa9RgN0jAjWel9jnR3ZoTv0N3xDqwavSHuNFReme1zhqnnE8DcOdtv9bQ-OxQU2RQKy98QBCmKKsiYRvcMuCgpZl_tNkMVd1lNVJTAVS1n17M) and contains compound in different stadia of human drug development.
The compounds were screened by luciferin at a concentration of 2 uM. That differs from the MMV compound libraries which were screened with XTT or MTS at 100 uM or 25 uM. Most of the in vitro hits were azoles. However, from the non-azoles, two compounds, both developed as NF-kB inhibitors, were able to prolong the survival of M. mycetomatis infected G. mellonella larvae. Surprisingly enough NF-kB is not found in fungi, so another protein should be the target in the fungi itself.