Hormonal contraceptive use and anaemia: A nation-wide pharmacoepidemiological study from Northern Europe

This repository contains R code to reproduce the analyses for the manuscript Hormonal contraceptive use and anaemia: A nation-wide pharmacoepidemiological study from Northern Europe (https://doi.org/10.1007/s10654-025-01272-3) by Ekroos S., Toffol E., Heikinheimo O., Haukka J. and Arvas M.

The code is included in five separate files. The first part, "hormonal_contraception_DAG.Rmd", creates the Directed Acyclic Graph used for model selection. The second part, "mkdataAnemiaV20240515_MA_V2.R", preprocessed the cohort data and sets up the Nested Case Control study. The third part, "data_exploration_V2.Rmd", allows the user to describe the cohort and original study population. The fourth part, "mkAnemiaModels_V2.R", runs the conditional logistic regression models and sensitivity analysis, which can then be visualized in the fifth part, "anemia_and_hc_V2.Rmd".

Information on packages needed to run the code is included in the .Rmd:s and .R:s.

For questions regarding the code or manuscript, please contact S Ekroos (sofie (dot) ekroos (at) helsinki (dot) fi).