Intra-individual variability in functional brain organization

This is the repository for the publication:

Bianca Serio, Deniz Yilmaz, Laura Pritschet, Hannah Grotzinger, Emily G. Jacobs, Simon B. Eickhoff, & Sofie L. Valk (2025). Exploring neuroendocrine influences on the sensorimotor-association axis in a female and male individual. Imaging Neuroscience. https://doi.org/10.1162/imag_a_00474.

Preprint version available here.

Scripts

1. Main analyses

• main.ipynb computes and visualizes main analyses
• p28Me_spin_permutation_lmer_within_between_network_dispersion_He_AM.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Male testosterone cortisol)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_He_AM_estr_test.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Male estrogen testosterone)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_He_AM_stress.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Male stress)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_Me.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Female estrogen progesterone)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_Me_estr_test.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Female estrogen testosterone)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_Me_stress.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Female stress)

2. Supplementary analyses

• p28Me_spin_permutation_lmer_within_between_network_dispersion_He_suppl_test_cort_pss.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Male testosterone cortisol stress)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_Me_estr_test_suppl_15.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Female estrogen testosterone n=15)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_Me_stress_suppl_20.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Female stress n=20)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_Me_suppl_20.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Female estrogen progresterone n=20)
• p28Me_spin_permutation_lmer_within_between_network_dispersion_Me_suppl_estr_prog_pss.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses (Female estrogen progresterone stress)
• p28_suppl_VAR.R Estimate first- and second-order vector autoregressive (VAR) models of S-A axis loadings vs estradiol using parallel processing
• ´permTestEdgeVAR.R´ Temporal permutation testing for edgewise VAR models
• ´p28_suppl_power.R´ Power analysis

3. Functions

• p28Me_myfunctions.ipynb contains functions used for main analyses

Data

• Open-access 28&Me sample (Pritschet et al., 2020), available on OpenNeuro.
• Open-access the 28&He sample (Grotzinger et al., 2024), available on OpenNeuro.

Support

Please address any questions about the analyses or code to Bianca Serio

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Research poster presented at:

• Annual Meeting of the Organization for Human Brain Mapping (OHBM), Seoul 2024

Please see Imaging Neuroscience publication for updated results