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Releases: AnalysisCommons/genesis_wdl

Version 1.4.1

16 Mar 14:23

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Genesis_nullmodel_v1.4.1
Updated to GENESIS_2.16.1 https://bioconductor.org/packages/release/bioc/html/GENESIS.html
Test.stat options are now Score and Score.SPA
Added transform option which will rank-normalize residuals, with optional rescaling, and re-fit null model
Added transform_rankNorm and transform_rescale for rescaling. Please see updateNullModOutcome() in GENESIS doc.

Genesis_tests_v1.4.1
Updated to GENESIS_2.16.1 https://bioconductor.org/packages/release/bioc/html/GENESIS.html
Test options are now Single, Burden, SKAT, fastSKAT, SMMAT and SKATO
Fixed error in documentation that said min.mac was not used for aggregate tests. It is. Set min_mac to 1 to include all variants below your top_maf threshold.
Added a filter for including pass_only variants.
Added genome_build option.
Added option to use imputed genotypes
Added parameters neig and ntrace for fastSKAT.
Changed the default instance type to mem3_ssd1_v2_x32
There is now an option ‘return_variants’ that will return an additional file with the single variant results that map to your aggregate test results.