llms.txt

# Disease Eradication Plan

> Academic research project proposing the 1% Treaty: redirecting 1% of global military spending to pragmatic clinical trials. Contains peer-reviewed analyses, governance frameworks, and implementation strategies.

This project consists of multiple interconnected research papers on health economics, regulatory reform, and democratic governance. All content is licensed under CC BY-NC 4.0.

## Core Concepts

- **1% Treaty**: International agreement to redirect 1% of military budgets to health research
- **dFDA**: Framework for automated drug assessment using real-world evidence
- **Predictor Impact Score**: Novel metric for causal inference from observational health data

## Research Papers

- [The 1% Treaty: Harnessing Greed to Eradicate Disease](https://manual.warondisease.org/knowledge/economics/1-pct-treaty-impact.html): 6.65 thousand diseases have zero FDA-approved treatments; at current trial capacity, exploring them takes ~443 years. Redirecting 1% of military spending scales capacity 12.3x, cutting the timeline to ~36 years and preventing 10.7 billion deaths. At $0.00177/DALY, 50.3kx more cost-effective than the best existing interventions. Incentive Alignment Bonds make adoption politically viable.
- [Algorithmic Public Administration: A Protocol for Replacing Government Intermediaries with Deterministic Functions](https://manual.warondisease.org/knowledge/appendix/algorithmic-public-administration.html): A protocol combining five primitives (transparent ledger, preference aggregation, evidence engine, identity verification, automated monetary policy) to replace mechanical government agency functions, eliminating administrative intermediation costs while preserving democratic control.
- [The Price of Political Change: A Cost-Benefit Framework for Policy Incentivization](https://manual.warondisease.org/knowledge/appendix/cost-of-change-analysis.html): What's the maximum cost to achieve any policy change through legal democratic channels? $25B for the US, $200B globally. For high-value reforms like military-to-health reallocation, this yields ROI exceeding 400,000:1.
- [Ubiquitous Pragmatic Trial Impact Analysis: How to Prevent a Year of Death and Suffering for 84 Cents](https://manual.warondisease.org/knowledge/appendix/dfda-impact-paper.html): Only 15 diseases/year get their first treatment each year. With 6.65 thousand diseases lacking effective treatments, the backlog would take 443 years to clear. Integrating pragmatic trials into standard healthcare increases trial capacity 12.3x, cutting that timeline from 443 years to 36 years. The average untreated disease gets a treatment 212 years earlier, saving 10.7 billion deaths at $0.842 per year of healthy life saved.
- [The Continuous Evidence Generation Protocol: Two-Stage Validation (RWE → Pragmatic Trials)](https://manual.warondisease.org/knowledge/appendix/dfda-spec-paper.html): We present the Predictor Impact Score (PIS), a novel composite metric operationalizing Bradford Hill causality criteria for automated signal detection from aggregated N-of-1 observational studies. Combined with pragmatic trial confirmation (based on evidence from 108+ embedded trials), this two-stage framework would generate validated outcome labels at 44.1x lower cost than traditional Phase III trials. This enables continuous, population-scale pharmacovigilance and precision dosing recommendations.
- [Drug Development Cost Increase Analysis](https://manual.warondisease.org/knowledge/appendix/drug-development-cost-analysis.html): Rigorous analysis of the 105x increase in drug development costs from pre-1962 to 2024, using Baily (1972) academic study with CPI adjustments and sensitivity analysis
- [Earth Optimization Prize Protocol: Technical Specification](https://manual.warondisease.org/knowledge/appendix/earth-optimization-prize-protocol.html): Technical specification for interoperable outcome prize pools structured as a dominant assurance contract. Covers cross-pool proof-of-personhood, a permissionless pool registry, VOTE and PRIZE token mechanics, direct cross-pool claims, tamper-evident scoreboard aggregation, and a terminal metric oracle including decentralized surveys.
- [The Earth Optimization Prize](https://manual.warondisease.org/knowledge/strategy/earth-optimization-prize.html): Reward humanity for raising healthy life years and median income within 15 years. PRIZE keeps depositors on the failure branch, VOTE rewards recruiters on the success branch, and Earth Optimization Protocol v1 is only the current instruction manual for trying to win.
- [Choose Your Own Earth: A World Without the Political Dysfunction Tax, or Terminal Parasitic Load in 15 Years](https://manual.warondisease.org/knowledge/economics/gdp-trajectories.html): Your destructive economy (military spending plus cybercrime) is already 11.5% of GDP and growing faster than your productive economy. At current rates, it reaches the Soviet collapse threshold in 8 years and exceeds productive output in 15. This paper models two GDP trajectories: the optimized path under military-to-medical reallocation, and the default path to civilizational collapse.
- [Incentive Alignment Bonds: Making Public Goods Financially and Politically Profitable](https://manual.warondisease.org/knowledge/appendix/incentive-alignment-bonds-paper.html): Government spending is optimized for lobbying intensity, not net societal value. Programs with 100:1 benefit-cost ratios get billions while programs with negative returns get hundreds of billions. Incentive Alignment Bonds flip this by creating a capital pool that rewards politicians (via campaign support and post-office opportunities) for funding high-NSV programs over low-NSV alternatives. The result: public good becomes private profit for both investors and elected officials.
- [The Invisible Graveyard: Quantifying the Mortality Cost of FDA Efficacy Lag](https://manual.warondisease.org/knowledge/appendix/invisible-graveyard.html): After proving a drug is safe, the FDA requires 8.2 years to prove it works before patients can access it. We estimate this delay cost 102 million deaths among people waiting for approved drugs (1962-2024). The human cost in death and disability of blocking good drugs is 3.07k higher than the cost of approving bad ones.
- [How to End War and Disease](https://manual.WarOnDisease.org): The Complete Idiot's Guide to Legally Bribing Your Way to Utopia
- [How to End War and Disease](https://manual.WarOnDisease.org): The Complete Idiot's Guide to Legally Bribing Your Way to Utopia
- [The Optimal Budget Generator: A Causal Inference Protocol for Maximizing Median Health and Wealth Through Public Goods Funding](https://manual.warondisease.org/knowledge/appendix/optimal-budget-generator-spec.html): The Optimal Budget Generator (OBG) uses causal inference, diminishing returns modeling, and cost-effectiveness evidence to determine optimal public goods funding levels that maximize two welfare metrics: real after-tax median income growth and median healthy life years. For each spending category, OBG estimates an Optimal Spending Level (OSL) and produces a gap analysis showing where current government budgets are over- or underfunded relative to evidence-based benchmarks. The Budget Impact Score (BIS) measures confidence in each recommendation based on the quality of causal evidence.
- [The Optimal Policy Generator: A Causal Inference Protocol for Maximizing Median Health and Wealth Through Public Policy](https://manual.warondisease.org/knowledge/appendix/optimal-policy-generator-spec.html): The Optimal Policy Generator (OPG) produces systematic public policy recommendations for jurisdictions at any level (country, state, city), generating prioritized enact/replace/repeal/maintain recommendations to maximize real after-tax median income growth and median healthy life years, based on quasi-experimental evidence from centuries of policy variation data.
- [Optimocracy: Causal Inference on Cross-Jurisdictional Policy Data to Maximize Median Health and Wealth](https://manual.warondisease.org/knowledge/appendix/optimocracy-paper.html): Thousands of jurisdictions have made different policy and budget choices over decades, creating a natural experiment. Optimocracy applies causal inference to this cross-jurisdictional time-series data to identify which policies predict above-average median income and healthy life years. It then publishes evidence-based recommendations for every major vote, tracks politician alignment, and funds aligned candidates via SuperPAC, making suboptimal policy politically expensive while preserving democratic structures.
- [The Organized Violence Tax](https://manual.warondisease.org/knowledge/problem/cost-of-war.html): Quantifying the compound cost of war since 1900: 310 million dead, $1.48 quadrillion in historical costs, and a 23x income multiple lost to eight compounding channels of destruction.
- [The Political Dysfunction Tax](https://manual.warondisease.org/knowledge/appendix/political-dysfunction-tax.html): Quantifying the gap between current global governance and theoretical maximum welfare, estimating a 31-53% efficiency score and $97 trillion in annual opportunity costs.
- [Right to Trial & FDA Upgrade Act](https://manual.warondisease.org/knowledge/appendix/right-to-trial-fda-upgrade-act.html): Act to modernize medical research and treatment access through an open-source FDA.gov v2, giving patients the right to participate in trials.
- [United States Efficiency Audit](https://manual.warondisease.org/knowledge/appendix/us-efficiency-audit.html): Systems audit estimating an annual U.S. efficiency gap of $4.9T, with $2.45T recoverable at OECD-median performance across direct spending waste, compliance burden, policy-induced GDP loss, and system inefficiency.
- [Wishocracy: Solving the Democratic Principal-Agent Problem Through Pairwise Preference Aggregation](https://manual.warondisease.org/knowledge/appendix/wishocracy-paper.html): Representative democracy suffers from an inescapable principal-agent problem where elected officials' incentives diverge from citizen welfare. Wishocracy introduces RAPPA (Randomized Aggregated Pairwise Preference Allocation), which aggregates citizen preferences through cognitively tractable pairwise comparisons and creates accountability via Citizen Alignment Scores that channel electoral resources toward politicians who actually represent what citizens want.

## Author

Mike P. Sinn
- Email: mike@warondisease.org
- Website: https://mikesinn.com
- ORCID: 0009-0006-0212-1094

## Organization

Institute for Accelerated Medicine
- Website: https://WarOnDisease.org

## Source Code

- [GitHub Repository](https://github.com/wishonia/earth-optimization-protocol)

## License

CC BY-NC 4.0 - Creative Commons Attribution-NonCommercial 4.0 International