_quarto-dfda-impact.yml

project:
  type: website
  output-dir: _site/dfda-impact
  execute-dir: project
  resources:
    - knowledge/data/
    - assets/
    - _redirects
    - robots.txt
    - llms.txt
  render:
    # Paper is copied to index.qmd by render script
    - index.qmd
    - knowledge/appendix/parameters-and-calculations.qmd
    - knowledge/appendix/economist-feedback-dfda.qmd

# Custom fields for render-quarto.py
dih-render:
  emoji: "💊"
  index-source: knowledge/appendix/dfda-impact-paper.qmd
  fallback-404-redirect-domain: https://manual.WarOnDisease.org  # Redirects here if path doesn't exist on this site
  pdf-output-file: dfda-impact-paper.pdf
  netlify-site-id: "a314a33e-3155-4067-8624-706266899419"
  netlify-cname: "impact-dfda-earth.netlify.app"
  show-confidence-intervals: true  # Show 95% CI ranges for calculated values in academic papers
  concept-terms:
    - term: "Ubiquitous Pragmatic Trial Impact Analysis"
      manual-target: knowledge/solution/dfda.qmd
      aliases:
        - "dFDA Impact Analysis"
  # Image generation prompts (used by scripts/images/generate-project-branding-images.ts)
  favicon-prompt: "A pill or capsule with an upward impact arrow."

profiles:
  default:
    dotenv:
      allowEmptyValues: true

author:
  - name: Mike P. Sinn
    email: m@warondisease.org
    orcid: 0009-0006-0212-1094
    affiliations:
      - name: "Institute for Accelerated Medicine"
        url: https://acceleratedmedicine.org

website:
  title: "Ubiquitous Pragmatic Trial Impact Analysis: How to Prevent a Year of Death and Suffering for 84 Cents"
  description: 'Only 15 diseases/year get their first treatment each year. With 6.65 thousand diseases lacking effective treatments, the backlog would take 443 years to clear. Integrating pragmatic trials into standard healthcare increases trial capacity 12.3x, cutting that timeline from 443 years to 36 years. The average untreated disease gets a treatment 212 years earlier, saving 10.7 billion deaths at $0.842 per year of healthy life saved.'
  site-url: https://manual.warondisease.org/knowledge/appendix/dfda-impact-paper.html
  favicon: assets/icons/dfda-favicon.png
  page-navigation: true
  page-footer:
    left: "© 2025 [Institute for Accelerated Medicine](https://acceleratedmedicine.org) | [CC BY-NC 4.0](https://creativecommons.org/licenses/by-nc/4.0/)"
    center: "[PDF](https://manual.warondisease.org/knowledge/appendix/dfda-impact-paper.pdf) | [All Papers](https://manual.warondisease.org/knowledge/papers.html)"
    right: "[VOTE](https://WarOnDisease.org)"
  navbar:
    right:
      - text: "dFDA Spec"
        href: https://dfda-spec.warondisease.org
      - text: "Prototype"
        href: https://dfda.earth
      - text: "Economist Review"
        href: knowledge/appendix/economist-feedback-dfda.qmd
      - text: "Calculations"
        href: knowledge/appendix/parameters-and-calculations.qmd
      - text: "VOTE"
        href: https://WarOnDisease.org

execute:
  fig-path: "knowledge/figures/"
  cache: false
  freeze: auto  # Only re-run cells when content changes
  daemon: 300
  daemon-restart: false
  env:
    PYTHONPATH: "."

metadata:
  importance: 98
  creator: "Mike P. Sinn"
  orcid: "0009-0006-0212-1094"
  primary-author: "Mike P. Sinn"
  byline: "Mike P. Sinn"
  human-author: "Mike P. Sinn"
  author-email: "mike@warondisease.org"
  author-url: "https://mikesinn.com"
  author-website: "https://mikesinn.com"
  contact: "mike@warondisease.org"
  language: "en-US"
  subject: "Health Economics, Cost-Benefit Analysis, ROI, Clinical Trials, Drug Development"
  category: "Academic Paper, Health Economics, Policy Analysis"
  coi-statement: "The author declares no competing interests, unless you count a vested interest in not dying, which the author shares with approximately 8 billion co-conspirators."
  data-availability: "All data and code used in this analysis are publicly available at https://github.com/wishonia/earth-optimization-protocol"
  ethics-statement: "This research did not involve human subjects. The 6,650 diseases with zero FDA-approved treatments were not consulted, as they were busy not being treated."
  funding: "This research received no funding. The author would like to note that the cost of producing the entire paper was roughly 84 cents per hour of work, which is coincidentally also the cost per DALY it proposes to achieve."
  github-profile: "https://github.com/mikepsinn"
  linkedin: "https://www.linkedin.com/in/mikesinn"
  orcid-url: "https://orcid.org/0009-0006-0212-1094"
  google-scholar: "https://scholar.google.com/citations?user=RjDd_qcAAAAJ"
  keywords:
    - dfda
    - cost-benefit-analysis
    - roi
    - return-on-investment
    - clinical-trials
    - drug-development
    - health-economics
    - pragmatic-trials
    - recovery-trial
    - real-world-evidence
    - regulatory-efficiency
    - decentralized-fda
  version: "0.9"
  edition: "Working Draft"
  copyright: "© 2025 The Institute for Accelerated Medicine"
  copyright-year: "2025"
  license: "CC BY-NC 4.0"
  license-url: "https://creativecommons.org/licenses/by-nc/4.0/"
  rights: "Creative Commons Attribution-NonCommercial 4.0 International License"
  publisher: "Institute for Accelerated Medicine"
  publisher-url: "https://acceleratedmedicine.org"
  publisher-name: "Mike P. Sinn"
  publisher-email: "mike@warondisease.org"
  repo-url: "https://github.com/wishonia/earth-optimization-protocol"
  issue-url: "https://github.com/wishonia/earth-optimization-protocol/issues"
  source-url: "https://github.com/wishonia/earth-optimization-protocol"
  geographic-coverage: "Global"
  audience: "Policy Makers, Health Economists, Regulatory Scientists, Investors, Healthcare Administrators"
  format: "Working Paper"
  type: "Academic"
  genre: "Health Economics, Policy Analysis, Cost-Benefit Analysis"
  medium: "Digital"
  twitter-site: "https://x.com/warondisease"
  twitter-creator: "https://x.com/warondisease"
  og-site-name: "The Health and Economic Impact of a Global System for Pragmatic Clinical Trials"

  # Identifiers
  # Zenodo Concept DOI (stable across all versions - use for citations and new versions)
  doi: "10.5281/zenodo.18243914"

  # Open Graph metadata (enables per-page custom OG images)
  open-graph: true
  image: "https://manual.warondisease.org/assets/og/dfda-impact-og-1200x630.jpg"

  # Publication tracking
  publishing:
    own-site:
      url: "https://manual.warondisease.org/knowledge/appendix/dfda-impact-paper.html"
      status: deployed
    preprints:
      - platform: zenodo
        status: auto-uploaded
        url: "https://zenodo.org/record/18522032"
        doi: "10.5281/zenodo.18243914"
      - platform: medrxiv
        status: pending
        url: ""
      - platform: ssrn
        status: pending
        url: ""
    journals:
      - name: "Value in Health"
        tier: 2
        status: target
        url: ""
      - name: "Health Affairs"
        tier: 1
        status: target
        url: ""
      - name: "PharmacoEconomics"
        tier: 2
        status: target
        url: ""

# Remove "Appendix" prefix
language:
  crossref-apx-prefix: ""
  section-title-appendices: ""

# Bibliography: Single source of truth for all citations
bibliography: references.bib
csl: nature-annotated.csl  # Renders 'abstract' field (quotes) in bibliography

jupyter: dih-project-kernel

format:
  html:
    lightbox: auto
    theme:
      - cosmo
    mermaid:
      theme: neutral
    echo: false
    number-sections: true
    toc: true
    toc-depth: 3
    css:
      - styles.css
      - economics-overrides.css
    include-before-body:
      - file: assets/html/page-loader.html
    include-after-body:
      - file: assets/html/site-enhancements-loader.html
    include-in-footer:
      - file: assets/html/generated-footer.html
    include-in-header:
      - text: |
          <!-- Icons (project-specific) -->
          <link rel="icon" type="image/png" sizes="32x32" href="/assets/icons/dfda-favicon-32x32.png">
          <link rel="icon" type="image/png" sizes="16x16" href="/assets/icons/dfda-favicon-16x16.png">
          <link rel="apple-touch-icon" sizes="180x180" href="/assets/icons/dfda-apple-touch-icon.png">
          <link rel="icon" type="image/png" sizes="192x192" href="/assets/icons/dfda-android-chrome-192x192.png">
          <link rel="icon" type="image/png" sizes="512x512" href="/assets/icons/dfda-android-chrome-512x512.png">
      - file: assets/html/google-analytics.html
      - file: assets/html/hypothesis.html
      - file: assets/html/fonts-preload.html
    citation-hover: true
    code-fold: true
    link-citations: true
    smooth-scroll: true
    code-tools: false
    filters: [assets/filters/live-version-note.lua]
  pdf:
    output-file: "dfda-impact-paper.pdf"
    documentclass: article
    institute: "Institute for Accelerated Medicine"
    echo: false
    toc: true
    toc-depth: 3
    number-sections: true
    colorlinks: true
    link-citations: true
    date: ""
    include-in-header:
      - callout-bw.tex
      - institute-header.tex
      - text: |
          \paperurl{https://manual.warondisease.org/knowledge/appendix/dfda-impact-paper.html}
    geometry:
      - top=1in
      - bottom=1in
      - left=1in
      - right=1in
    fontsize: 11pt
    filters: [assets/filters/live-version-note.lua]