diff --git a/requirements.txt b/requirements.txt
index 38896e5..80f0df9 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -12,7 +12,7 @@ opencv-python==4.0.0.21
 openslide-python==1.1.1
 pandas==0.24.1
 Pillow==6.2.0
-protobuf==3.7.0
+protobuf==4.25.8
 pyparsing==2.3.1
 python-dateutil==2.8.0
 pytz==2018.9