send() failed (111: Connection refused)

[1450793561]

nginx日志一直刷新“111: Connection refused”这个错误，有解决方法么？

2024/08/15 14:30:50 [error] 3838#0: send() failed (111: Connection refused)
2024/08/15 14:30:53 [error] 3838#0: send() failed (111: Connection refused)
2024/08/15 14:30:54 [alert] 3690#0: cache manager process 3986 exited on signal 11
2024/08/15 14:30:56 [error] 3838#0: send() failed (111: Connection refused)
2024/08/15 14:30:59 [error] 3838#0: send() failed (111: Connection refused)
2024/08/15 14:31:02 [error] 3838#0: send() failed (111: Connection refused)
2024/08/15 14:31:04 [alert] 3690#0: cache manager process 3995 exited on signal 11
2024/08/15 14:31:05 [error] 3838#0: send() failed (111: Connection refused)

nginx配置如下：
upstream xxxxxx{
server 127.0.0.1:11111;
upsync consul.com:8500/v1/kv/upstreams/pxxxnx/xxxxxxxx upsync_timeout=10000ms upsync_interval=10000ms upsync_type=consul strong_dependency=off;
upsync_dump_path /usr/local/manual/admin.conf;
include /usr/local/manual/admin.conf;
check interval=3000 rise=2 fall=5 timeout=1000 type=http;
check_http_send "GET /bpm/heart/piercestatus HTTP/1.0\r\n\r\n";
check_http_expect_alive http_2xx http_3xx;
}