Just as an example, U+0F35 TIBETAN MARK NGAS BZUNG NYI ZLA and U+0F37 TIBETAN MARK NGAS BZUNG SGOR RTAGS, used to create a similar effect to underlining or to mark emphasis, should be ignored for text processing operations such as search. See https://www.w3.org/TR/tlreq/#emphasis_and_highlighting
Currently, it works in Chrome and Firefox, but not in Safari.