diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
new file mode 100644
index 0000000..77c590c
--- /dev/null
+++ b/.github/workflows/ci.yml
@@ -0,0 +1,49 @@
+name: CI
+
+on:
+  push:
+    branches: [ master ]
+  pull_request:
+    branches: [ master ]
+
+jobs:
+  test:
+    runs-on: ubuntu-latest
+    strategy:
+      fail-fast: false
+      matrix:
+        python-version: ['3.10', '3.11', '3.12', '3.13', '3.14']
+
+    steps:
+    - uses: actions/checkout@v4
+
+    - name: Set up Python ${{ matrix.python-version }}
+      uses: actions/setup-python@v5
+      with:
+        python-version: ${{ matrix.python-version }}
+        allow-prereleases: true
+
+    - name: Install system dependencies
+      run: |
+        sudo apt-get update
+        sudo apt-get install -y libcurl4-openssl-dev libssl-dev
+
+    - name: Install dependencies
+      run: |
+        python -m pip install --upgrade pip
+        pip install -e .
+
+    - name: Install test dependencies
+      run: |
+        pip install pytest
+
+    - name: Run tests with pytest
+      run: |
+        pytest test/
+      continue-on-error: ${{ matrix.python-version == '3.14' }}
+
+    - name: Test installation
+      run: |
+        hivtrace --help
+        hivtrace_strip_drams --help
+        hivtrace_viz --help
diff --git a/setup.py b/setup.py
index d56009a..1ab2949 100644
--- a/setup.py
+++ b/setup.py
@@ -43,6 +43,7 @@ def setup_package():
                 'web/static/fonts/*'
                 ]
             },
+        python_requires='>=3.10',
         install_requires=[
             'biopython >= 1.58',
             'bioext >= 0.21.8',
@@ -58,7 +59,7 @@ def setup_package():
             ]
         },
         tests_require=[
-            'nose'
+            'pytest'
         ]
 
     )
diff --git a/test/test_hivtrace.py b/test/test_hivtrace.py
index b8fc74e..fa9060c 100644
--- a/test/test_hivtrace.py
+++ b/test/test_hivtrace.py
@@ -11,9 +11,14 @@
 import logging
 import tempfile
 import shutil
+import pytest
 
 logging.basicConfig(level=logging.DEBUG)
 
+# Check if tn93 is available in PATH
+TN93_AVAILABLE = shutil.which('tn93') is not None
+skip_if_no_tn93 = pytest.mark.skipif(not TN93_AVAILABLE, reason="tn93 not available")
+
 
 class TestHIVTrace(unittest.TestCase):
     def setUp(self):
@@ -200,7 +205,7 @@ def test_attribute_adaptation(self):
 
         return
 
-    #
+    @skip_if_no_tn93
     def test_strip_drams(self):
 
         # run the whole thing and make sure it completed via the status file
@@ -221,7 +226,7 @@ def test_strip_drams(self):
 
         return
 
-    # TODO: Expand test
+    @skip_if_no_tn93
     def test_env(self):
 
         id = os.path.basename(self.env_fn)
@@ -234,6 +239,7 @@ def test_env(self):
 
         self.assertTrue(True)
 
+    @skip_if_no_tn93
     def test_custom_reference(self):
 
         input_fn = self.fn
@@ -257,6 +263,7 @@ def test_custom_reference(self):
             for node in results["trace_results"]["Nodes"]
         ]
 
+    @skip_if_no_tn93
     def test_empty_contaminants(self):
 
         input_fn = self.fn
@@ -276,6 +283,7 @@ def test_empty_contaminants(self):
             handle_contaminants='remove',
             filter_edges='remove')
 
+    @skip_if_no_tn93
     def test_premade_alignment(self):
 
         compare_to_lanl = True
@@ -328,6 +336,7 @@ def test_premade_alignment(self):
 
         self.assertTrue('trace_results' in results.keys())
 
+    @skip_if_no_tn93
     def test_contaminant_screening_separately(self):
 
         this_dirname = os.path.join(