COSMIC Card

[SSU02]

Description of database

COSMIC – the Catalogue of Somatic Mutations in Cancer – is the world's largest source of expert manually curated somatic mutation information relating to human cancers. Available for both GRCh37 and GRCh38.

Access (API or download)

Free registration for academic use; commercial use requires a licence.

File format

tsv files
Sample of COSMIC data is available for download here: https://cancer.sanger.ac.uk/cosmic/about
(first 100 lines of each of the download files freely available )

Investigation with dataset

(I downloaded the GRCh37 data sample)

List of tsv files:

1. Actionability_AllData_v9_GRCh37.tsv
2. CancerMutationCensus_AllData_v98_GRCh37.tsv
3. CellLinesProject_CompleteCNA_v98_GRCh37.tsv
4. CellLinesProject_CompleteGeneExpression_v98_GRCh37.tsv
5. CellLinesProject_GenomeScreensMutant_v98_GRCh37.tsv
6. CellLinesProject_MutationTracking_v98_GRCh37.tsv
7. CellLinesProject_NonCodingVariants_v98_GRCh37.tsv
8. CellLinesProject_RawGeneExpression_v98_GRCh37.tsv
9. CellLinesProject_Sample_v98_GRCh37.tsv
10. Cosmic_Breakpoints_v98_GRCh37.tsv
11. Cosmic_CancerGeneCensusHallmarksOfCancer_v98_GRCh37.tsv
12. Cosmic_CancerGeneCensus_v98_GRCh37.tsv
13. Cosmic_Classification_v98_GRCh37.tsv
14. Cosmic_CompleteCNA_v98_GRCh37.tsv
15. Cosmic_CompleteDifferentialMethylation_v98_GRCh37.tsv
16. Cosmic_CompleteGeneExpression_v98_GRCh37.tsv
17. Cosmic_CompleteTargetedScreensMutant_v98_GRCh37.tsv
18. Cosmic_Fusion_v98_GRCh37.tsv
19. Cosmic_Genes_v98_GRCh37.tsv
20. Cosmic_GenomeScreensMutant_v98_GRCh37.tsv
21. Cosmic_MutantCensus_v98_GRCh37.tsv
22. Cosmic_MutationTracking_v98_GRCh37.tsv
23. Cosmic_NonCodingVariants_v98_GRCh37.tsv
24. Cosmic_ResistanceMutations_v98_GRCh37.tsv
25. Cosmic_Sample_v98_GRCh37.tsv
26. Cosmic_StructuralVariants_v98_GRCh37.tsv
27. Cosmic_Transcripts_v98_GRCh37.tsv

Of these files 2)CancerMutationCensus_AllData_v98_GRCh37.tsv has information regarding pathogenicity and mutation type.