diff --git a/.gitignore b/.gitignore
new file mode 100644
index 000000000..a273eef19
--- /dev/null
+++ b/.gitignore
@@ -0,0 +1,101 @@
+# Byte-compiled / optimized / DLL files
+__pycache__/
+*.py[cod]
+*$py.class
+
+# C extensions
+*.so
+
+# Distribution / packaging
+.Python
+env/
+build/
+develop-eggs/
+dist/
+downloads/
+eggs/
+.eggs/
+lib/
+lib64/
+parts/
+sdist/
+var/
+*.egg-info/
+.installed.cfg
+*.egg
+
+# PyInstaller
+#  Usually these files are written by a python script from a template
+#  before PyInstaller builds the exe, so as to inject date/other infos into it.
+*.manifest
+*.spec
+
+# Installer logs
+pip-log.txt
+pip-delete-this-directory.txt
+
+# Unit test / coverage reports
+htmlcov/
+.tox/
+.coverage
+.coverage.*
+.cache
+nosetests.xml
+coverage.xml
+*,cover
+.hypothesis/
+
+# Translations
+*.mo
+*.pot
+
+# Django stuff:
+*.log
+local_settings.py
+
+# Flask stuff:
+instance/
+.webassets-cache
+
+# Scrapy stuff:
+.scrapy
+
+# Sphinx documentation
+docs/_build/
+
+# PyBuilder
+target/
+
+# IPython Notebook
+.ipynb_checkpoints
+
+# pyenv
+.python-version
+
+# celery beat schedule file
+celerybeat-schedule
+
+# dotenv
+.env
+
+# virtualenv
+venv/
+ENV/
+
+# Spyder project settings
+.spyderproject
+
+# Rope project settings
+.ropeproject
+
+# PyCharm project settings
+.idea/*
+
+*.pickle
+*.gpickle
+
+scratch
+scratch/*
+
+.pytest_cache
+.DS_Store
diff --git a/.travis.yml b/.travis.yml
index 04320e5bb..dc7b60aba 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -4,25 +4,21 @@ python:
 before_install:
   - sudo apt-get install graphviz
   - pwd
-  - pip install future requests pygraphviz
-  - if [[ "$TRAVIS_PYTHON_VERSION" == "2.7" ]]; then
-      pip install functools32;
-    fi
+  - pip install future requests pygraphviz bel_resources
   - git clone https://github.com/sorgerlab/indra.git
 script:
   - pwd
   - echo $TRAVIS_BUILD_DIR
   - export PYTHONPATH=$PYTHONPATH:$TRAVIS_BUILD_DIR/indra
-  - python check_references.py
-  - python export/relations_graph.py
+  - python famplex/check_references.py
+  - python famplex/export/export_relations_graph.py
   # test if exports have been updated
   # bel_resources must be installed to generate belns exports
   # generate exports then take git diff and look only at lines that changed
   # lines containing date, timestamp, or version should be ignored
-  - pip install bel_resources
-  - python export/obo.py
-  - python export/hgnc_ids.py
-  - python export/belns.py
+  - python famplex/export/export_obo.py
+  - python famplex/export/hgnc_ids.py
+  - python famplex/export/export_belns.py
   - export belns_diff=$(git diff -U0 export/famplex.belns | egrep "^[\+-][^\+-]")
   - export belns=$(echo "$belns_diff" | egrep -v "^[\+-](VersionString|CreatedDateTime)")
   - export obo_diff=$(git diff -U0 export/famplex.obo | egrep "^[\+-][^\+-]")
diff --git a/README.md b/README.md
index 93996b60c..c9ce4320e 100644
--- a/README.md
+++ b/README.md
@@ -31,6 +31,10 @@ the FamPlex namespace.
 
 * ```entities.csv```. A registry of the families and complexes defined in the
   FamPlex namespace.
+  
+* ```descriptions.csv```. Descriptions and citations of some entities. Contains
+  three columns: the FamPlex name, comma separated reference CURIEs, and a 
+  textual description.
 
 * ```grounding_map.csv```. Explicit mapping of text strings to identifiers in
   biological databases.
@@ -61,7 +65,7 @@ relationships, including sub-families (families within families) and complexes
 consisting of families of related subunits (e.g., PI3K, NF-kB).
 
 The ```relations.csv``` file consists of five columns: (1) the namespace for
-the subject (e.g., ```HGNC``` for gene names, ```UP``` for Uniprot, or
+the subject (e.g., ```HGNC``` for gene names, ```UP``` for UniProt, or
 ```FPLX``` for the FamPlex namespace), (2) the identifier for the subject,
 (3) the relationship (```isa``` or ```partof```), (4) the namespace for the
 object, and (5) the identifier for the object.
@@ -87,10 +91,10 @@ cancer.
 
 Entities are grounded to the following databases:
 
-* Genes/proteins: [Uniprot](http://www.uniprot.org)
+* Genes/proteins: [UniProt](http://www.uniprot.org)
 
 * Chemicals: [PubChem](https://pubchem.ncbi.nlm.nih.gov/),
-  [CHEBI](https://www.ebi.ac.uk/chebi/), and [HMDB](http://www.hmdb.ca/) (for
+  [ChEBI](https://www.ebi.ac.uk/chebi/), and [HMDB](http://www.hmdb.ca/) (for
   metabolites)
 
 * Biological processes: [GO](http://geneontology.org/) and
@@ -99,7 +103,7 @@ Entities are grounded to the following databases:
 * Protein families and named complexes: grounded to entities defined within
   the FamPlex repository in the ```entities.csv``` and ```relations.csv```
   files, and to identifiers in [PFAM](http://pfam.xfam.org/)
-  and [Interpro](https://www.ebi.ac.uk/interpro/) when possible.
+  and [InterPro](https://www.ebi.ac.uk/interpro/) when possible.
 
 ## Gene prefixes
 
diff --git a/check_references.py b/check_references.py
deleted file mode 100644
index 93d80912d..000000000
--- a/check_references.py
+++ /dev/null
@@ -1,322 +0,0 @@
-from __future__ import print_function, unicode_literals
-import csv
-import sys
-from collections import Counter
-
-
-def read_csv(fh, delimiter, quotechar):
-    if sys.version_info.major < 3:
-        csvreader = csv.reader(fh, delimiter=bytes(delimiter),
-                               quotechar=bytes(quotechar))
-        rows = [[cell.decode('utf-8') for cell in row] for row in csvreader]
-    else:
-        csvreader = csv.reader(fh, delimiter=delimiter, quotechar=quotechar)
-        rows = [row for row in csvreader]
-    return rows
-
-
-def load_csv(filename):
-    with open(filename) as f:
-        rows = read_csv(f, ',', '"')
-    return rows
-
-
-def load_grounding_map(filename):
-    gm_rows = load_csv(filename)
-    gm_tuples = []
-    check_rows(gm_rows, 7, filename)
-    g_map = {}
-    for row in gm_rows:
-        gm_tuples.append(tuple(row))
-        key = row[0]
-        db_refs = {'TEXT': key}
-        keys = [entry for entry in row[1::2] if entry != '']
-        values = [entry for entry in row[2::2] if entry != '']
-        if len(keys) != len(values):
-            print('ERROR: Mismatched keys and values in row %s' % str(row))
-            continue
-        else:
-            db_refs.update(dict(zip(keys, values)))
-            if len(db_refs.keys()) > 1:
-                g_map[key] = db_refs
-            else:
-                g_map[key] = None
-    return g_map, tuple(gm_tuples)
-
-
-def check_file_rows(filename, row_length):
-    with open(filename) as f:
-        rows = read_csv(f, ',', '"')
-    check_rows(rows, row_length, filename)
-
-
-def check_rows(rows, row_length, filename):
-    for ix, row in enumerate(rows):
-        if len(row) != row_length:
-            print("ERROR: Line %d in file %s has %d columns, should be %d" %
-                  ((ix + 1), filename, len(row), row_length))
-
-
-def load_entity_list(filename):
-    with open(filename) as f:
-        rows = read_csv(f, ',', '"')
-    check_rows(rows, 1, filename)
-    entities = [row[0] for row in rows]
-    return entities
-
-
-def load_relationships(filename):
-    relationships = []
-    with open(filename) as f:
-        rows = read_csv(f, ',', '"')
-    check_rows(rows, 5, filename)
-    for row in rows:
-        relationships.append(((row[0], row[1]), row[2], (row[3], row[4])))
-    return relationships
-
-
-def load_equivalences(filename):
-    equivalences = []
-    with open(filename) as f:
-        rows = read_csv(f, ',', '"')
-    check_rows(rows, 3, filename)
-    for row in rows:
-        equivalences.append((row[0], row[1], row[2]))
-    return equivalences
-
-
-def update_id_prefixes(filename):
-    gm_rows = load_csv(filename)
-    updated_rows = []
-    for row in gm_rows:
-        key = row[0]
-        keys = [entry for entry in row[1::2]]
-        values = [entry for entry in row[2::2]]
-        if 'GO' in keys:
-            go_ix = keys.index('GO')
-            values[go_ix] = 'GO:%s' % values[go_ix]
-        if 'CHEBI' in keys:
-            chebi_ix = keys.index('CHEBI')
-            values[chebi_ix] = 'CHEBI:%s' % values[chebi_ix]
-        if 'CHEMBL' in keys:
-            chembl_ix = keys.index('CHEMBL')
-            values[chembl_ix] = 'CHEMBL%s' % values[chembl_ix]
-        updated_row = [key]
-        for pair in zip(keys, values):
-            updated_row += pair
-        updated_rows.append(updated_row)
-    return updated_rows
-
-
-def pubchem_and_chebi(db_refs):
-    pubchem_id = db_refs.get('PUBCHEM')
-    chebi_id = db_refs.get('CHEBI')
-    if pubchem_id and not chebi_id:
-        return 'chebi_missing'
-    if chebi_id and not pubchem_id:
-        return 'pubchem_missing'
-    return None
-
-
-def check_duplicates(entries, entry_label):
-    ent_counter = Counter(entries)
-    print("-- Checking for duplicate %s --" % entry_label)
-    found_duplicates = False
-    for ent, freq in ent_counter.items():
-        if freq > 1:
-            print("ERROR: Duplicate %s in %s." % (str(ent), entry_label))
-            found_duplicates = True
-    print()
-    return found_duplicates
-
-
-if __name__ == '__main__':
-    signal_error = False
-    entities = load_entity_list('entities.csv')
-    relationships = load_relationships('relations.csv')
-    equivalences = load_equivalences('equivalences.csv')
-    gm, gm_tuples = load_grounding_map('grounding_map.csv')
-    check_file_rows('gene_prefixes.csv', 3)
-
-    for entries, entry_label in ((entities, 'entities'),
-                                 (relationships, 'relationships'),
-                                 (equivalences, 'equivalences'),
-                                 (gm_tuples, 'groundings')):
-        if check_duplicates(entries, entry_label):
-            signal_error = True
-
-    print("-- Checking for undeclared FamPlex IDs in grounding map --")
-    # Look through grounding map and find all instances with an FPLX db key
-    entities_missing_gm = []
-    for text, db_refs in gm.items():
-        if db_refs is not None:
-            for db_key, db_id in db_refs.items():
-                if db_key == 'FPLX' and db_id not in entities:
-                    entities_missing_gm.append(db_id)
-                    print("ERROR: ID %s referenced in grounding map "
-                          "is not in entities list." % db_id)
-                    signal_error = True
-
-    print()
-    print("-- Checking for CHEBI/PUBCHEM IDs--")
-    chebi_id_missing = []
-    pubchem_id_missing = []
-    for text, db_refs in gm.items():
-        if db_refs is not None:
-            p_and_c = pubchem_and_chebi(db_refs)
-            if p_and_c == 'chebi_missing':
-                chebi_id_missing.append(db_refs['PUBCHEM'])
-                print("WARNING: %s has PUBCHEM ID (%s) but no CHEBI ID."
-                      % (text, db_refs['PUBCHEM']))
-            if p_and_c == 'pubchem_missing':
-                pubchem_id_missing.append(db_refs['CHEBI'])
-                print("WARNING: %s has CHEBI ID (%s) but no PUBCHEM ID." %
-                      (text, db_refs['CHEBI']))
-
-    print()
-    print("-- Checking for undeclared FamPlex IDs in relationships file --")
-    # Load the relationships
-    # Check the relationships for consistency with entities
-    entities_missing_rel = []
-    for subj, rel, obj in relationships:
-        for term in (subj, obj):
-            term_ns = term[0]
-            term_id = term[1]
-            if term_ns == 'FPLX' and term_id not in entities:
-                entities_missing_rel.append(term_id)
-                print("ERROR: ID %s referenced in relations "
-                      "is not in entities list." % term_id)
-                signal_error = True
-    print()
-    print("-- Checking for valid namespaces in relations --")
-    for ix, (subj, rel, obj) in enumerate(relationships):
-        for term in (subj, obj):
-            term_ns = term[0]
-            if term_ns not in ('FPLX', 'HGNC', 'UP'):
-                print("ERROR: row %d: Invalid namespace in relations.csv: %s" %
-                      (ix+1, term_ns))
-                signal_error = True
-
-    # This check requires the indra package
-    try:
-        from indra.databases import hgnc_client
-        print()
-        print("-- Checking for invalid HGNC IDs in relationships file --")
-        for subj, rel, obj in relationships:
-            for term in (subj, obj):
-                term_ns = term[0]
-                term_id = term[1]
-                if term_ns == 'HGNC':
-                    hgnc_id = hgnc_client.get_hgnc_id(term_id)
-                    if not hgnc_id:
-                        print("ERROR: ID %s referenced in relations is "
-                              "not a valid HGNC ID." % term_id)
-                        signal_error = True
-    except ImportError as e:
-        print('HGNC check could not be performed because of import error')
-        print(e)
-        signal_error = True
-        pass
-
-    # This check requires the indra package
-    try:
-        from indra.databases import hgnc_client
-        print()
-        print("-- Checking for invalid HGNC IDs in grounding map --")
-        for text, db_refs in gm.items():
-            if db_refs is not None:
-                for db_key, db_id in db_refs.items():
-                    if db_key == 'HGNC':
-                        hgnc_id = hgnc_client.get_hgnc_id(db_id)
-                        if not hgnc_id:
-                            print("ERROR: ID %s in grounding map is "
-                                   "not a valid HGNC ID." % db_id)
-                            signal_error = True
-    except ImportError:
-        print('HGNC check could not be performed because of import error')
-        print(e)
-        signal_error = True
-        pass
-
-    # This check requires a ChEBI resource file to be available. You
-    # can obtain it from here: ftp://ftp.ebi.ac.uk/pub/databases/
-    #                          chebi/Flat_file_tab_delimited/compounds.tsv.gz
-    try:
-        with open('chebi_compounds.tsv', 'rt') as fh:
-            chebi_ids = [lin.split('\t')[2] for lin in fh.readlines()]
-        print()
-        print("-- Checking for invalid ChEBI IDs in grounding map --")
-        for text, db_refs in gm.items():
-            if db_refs is not None:
-                for db_key, db_id in db_refs.items():
-                    if db_key == 'CHEBI':
-                        if db_id not in chebi_ids:
-                            print("ERROR: ID %s in grounding map is "
-                                  "not a valid CHEBI ID." % db_id)
-    except IOError:
-        pass
-
-    print()
-    print("-- Checking for FamPlexes whose relationships are undefined  --")
-    # Check the relationships for consistency with entities
-    rel_missing_entities = []
-    for ent in entities:
-        found = False
-        for subj, rel, obj in relationships:
-            subj_ns = subj[0]
-            subj_id = subj[1]
-            obj_ns = obj[0]
-            obj_id = obj[1]
-            if subj_ns == 'FPLX' and subj_id == ent:
-                found = True
-                break
-            if obj_ns == 'FPLX' and obj_id == ent:
-                found = True
-                break
-        if not found:
-            rel_missing_entities.append(ent)
-            print("WARNING: ID %s has no known relations." % ent)
-
-    print()
-    print("-- Checking for non-existent FamPlexes in equivalences  --")
-    entities_missing_eq = []
-    for eq_ns, eq_id, be_id in equivalences:
-        if be_id not in entities:
-            signal_error = True
-            entities_missing_eq.append(be_id)
-            print("ERROR: ID %s referenced in equivalences "
-                  "is not in entities list." % be_id)
-    print()
-    print("-- Checking for duplicate equivalences --")
-    equiv_counter = Counter(equivalences)
-    duplicate_eq = [item for item, count in equiv_counter.items()
-                    if count > 1]
-    if duplicate_eq:
-        print("ERROR: Duplicate equivalences found:")
-        for dup in duplicate_eq:
-            print(dup)
-
-    # This check requires the requests package to be installed
-    try:
-        import requests
-        import logging
-        logging.getLogger('requests').setLevel(logging.CRITICAL)
-        logging.getLogger('urllib3').setLevel(logging.CRITICAL)
-        print()
-        print("-- Checking for invalid PUBCHEM CIDs in grounding map --")
-        pubchem_url = 'https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/' + \
-                      'cid/%s/description/XML'
-        for text, db_refs in gm.items():
-            if db_refs is not None:
-                for db_key, db_id in db_refs.items():
-                    if db_key == 'PUBCHEM':
-                        res = requests.get(pubchem_url % db_id)
-                        if res.status_code != 200:
-                            print("ERROR: ID %s in grounding map is "
-                                  "not a valid PUBCHEM ID." % db_id)
-    except ImportError:
-        pass
-
-    if signal_error:
-        sys.exit(1)
-    sys.exit(0)
diff --git a/descriptions.csv b/descriptions.csv
new file mode 100644
index 000000000..2b014b150
--- /dev/null
+++ b/descriptions.csv
@@ -0,0 +1 @@
+CBF3,interpro:IPR016072,"SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex"
diff --git a/export/__init__.py b/export/__init__.py
deleted file mode 100644
index e69de29bb..000000000
diff --git a/export/famplex.belns b/export/famplex.belns
index 4d18c7c15..23b26d4eb 100644
--- a/export/famplex.belns
+++ b/export/famplex.belns
@@ -2,8 +2,8 @@
 Keyword=FPLX
 NameString=FamPlex
 DomainString=Gene and Gene Products
-VersionString=20190714
-CreatedDateTime=2019-07-14T13:17:44
+VersionString=20190721
+CreatedDateTime=2019-07-21T18:50:59
 DescriptionString=FamPlex is a collection of resources for grounding biological entities from text and describing their hierarchical relationships.
 QueryValueURL=http://identifiers.org/fplx/
 [Author]
diff --git a/export/famplex.obo b/export/famplex.obo
index 8a87d7777..9aba29ba7 100644
--- a/export/famplex.obo
+++ b/export/famplex.obo
@@ -1,40 +1,59 @@
 format-version: 1.2
-date: 14:07:2019 13:17
+date: 21:07:2019 18:51
+ 
+[Typedef]
+id: part_of
+name: part of
+namespace: external
+xref: BFO:0000050
+is_transitive: true
+
+[Typedef]
+id: inverse_is_a
+name: inverse is_a
+
+[Typedef]
+id: has_part
+name: has part
+
+[Term]
+id: FPLX:000000
+name: famplex
 
 [Term]
-id: FPLX:9_1_1
+id: FPLX:000001
 name: 9-1-1
 synonym: "(9-1-1) complex" EXACT []
 synonym: "9-1-1 complex" EXACT []
 synonym: "9-1-1" EXACT []
 synonym: "h9-1-1 complex" EXACT []
 xref: BEL:"9-1-1 Complex"
-is_a: FPLX:root
-has_part: HGNC:HUS1
-has_part: HGNC:RAD1
-has_part: HGNC:RAD9A
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:5309 ! HUS1
+relationship: has_part HGNC:9806 ! RAD1
+relationship: has_part HGNC:9827 ! RAD9A
 
 [Term]
-id: FPLX:A4GALT_family
+id: FPLX:000002
 name: A4GALT-family
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:A4GALT
-inverse_is_a: HGNC:A4GNT
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:18149 ! A4GALT
+relationship: inverse_is_a HGNC:17968 ! A4GNT
 
 [Term]
-id: FPLX:ABL_family
+id: FPLX:000003
 name: ABL-family
 synonym: "ABL family" EXACT []
 synonym: "ABL" EXACT []
 xref: IP:IPR015015
 xref: MEDSCAN:urn:agi-aopfc:0000567
 xref: RE:R-HSA-376002
-is_a: FPLX:root
-inverse_is_a: HGNC:ABL1
-inverse_is_a: HGNC:ABL2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:76 ! ABL1
+relationship: inverse_is_a HGNC:77 ! ABL2
 
 [Term]
-id: FPLX:ACAD
+id: FPLX:000004
 name: ACAD
 synonym: "ACAD" EXACT []
 synonym: "acyl CoA dehydrogenase" EXACT []
@@ -42,21 +61,21 @@ synonym: "acyl-CoA dehydrogenase" EXACT []
 xref: BEL:"ACAD Family"
 xref: ECCODE:1.3.8.7
 xref: NEXTPROT-FAMILY:00093
-is_a: FPLX:root
-inverse_is_a: HGNC:ACAD8
-inverse_is_a: HGNC:ACAD9
-inverse_is_a: HGNC:ACADL
-inverse_is_a: HGNC:ACADM
-inverse_is_a: HGNC:ACADS
-inverse_is_a: HGNC:ACADVL
-inverse_is_a: HGNC:ACAD10
-inverse_is_a: HGNC:ACAD11
-inverse_is_a: HGNC:ACADSB
-inverse_is_a: HGNC:GCDH
-inverse_is_a: HGNC:IVD
-
-[Term]
-id: FPLX:ACC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:87 ! ACAD8
+relationship: inverse_is_a HGNC:21497 ! ACAD9
+relationship: inverse_is_a HGNC:88 ! ACADL
+relationship: inverse_is_a HGNC:89 ! ACADM
+relationship: inverse_is_a HGNC:90 ! ACADS
+relationship: inverse_is_a HGNC:92 ! ACADVL
+relationship: inverse_is_a HGNC:21597 ! ACAD10
+relationship: inverse_is_a HGNC:30211 ! ACAD11
+relationship: inverse_is_a HGNC:91 ! ACADSB
+relationship: inverse_is_a HGNC:4189 ! GCDH
+relationship: inverse_is_a HGNC:6186 ! IVD
+
+[Term]
+id: FPLX:000005
 name: ACC
 synonym: "ACC" EXACT []
 synonym: "ACCs" EXACT []
@@ -67,12 +86,12 @@ xref: BEL:"Acetyl CoA Carboxylase Complex"
 xref: ECCODE:6.4.1.2
 xref: IP:IPR013537
 xref: RE:R-HSA-200563
-is_a: FPLX:root
-has_part: HGNC:ACACA
-has_part: HGNC:ACACB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:84 ! ACACA
+relationship: has_part HGNC:85 ! ACACB
 
 [Term]
-id: FPLX:Acetyl_CoA_synthetase
+id: FPLX:000006
 name: Acetyl-CoA-synthetase
 synonym: "Acetate-CoA ligase" EXACT []
 synonym: "acetyl CoA ligase" EXACT []
@@ -82,43 +101,43 @@ synonym: "acetyl-CoA synthetase" EXACT []
 synonym: "acetyl-coenzyme A synthase" EXACT []
 synonym: "ACS" EXACT []
 xref: BEL:"Acetyl-CoA Synthetase Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:SLC27A2
-inverse_is_a: HGNC:ACSL1
-inverse_is_a: HGNC:ACSL3
-inverse_is_a: HGNC:ACSL4
-inverse_is_a: HGNC:ACSL5
-inverse_is_a: HGNC:ACSL6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10996 ! SLC27A2
+relationship: inverse_is_a HGNC:3569 ! ACSL1
+relationship: inverse_is_a HGNC:3570 ! ACSL3
+relationship: inverse_is_a HGNC:3571 ! ACSL4
+relationship: inverse_is_a HGNC:16526 ! ACSL5
+relationship: inverse_is_a HGNC:16496 ! ACSL6
 
 [Term]
-id: FPLX:ACOX
+id: FPLX:000007
 name: ACOX
 synonym: "Acyl-CoA Oxidase" EXACT []
 synonym: "acyl-CoA oxidases" EXACT []
 xref: BEL:"ACOX Family"
 xref: IP:IPR002655
 xref: XFAM:PF01756
-is_a: FPLX:root
-inverse_is_a: HGNC:ACOX1
-inverse_is_a: HGNC:ACOX2
-inverse_is_a: HGNC:ACOX3
-inverse_is_a: HGNC:ACOXL
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:119 ! ACOX1
+relationship: inverse_is_a HGNC:120 ! ACOX2
+relationship: inverse_is_a HGNC:121 ! ACOX3
+relationship: inverse_is_a HGNC:25621 ! ACOXL
 
 [Term]
-id: FPLX:ACSL
+id: FPLX:000008
 name: ACSL
 synonym: "Acsl" EXACT []
 synonym: "long-chain acyl-CoA synthetase" EXACT []
 xref: BEL:"ACSL Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:ACSL1
-inverse_is_a: HGNC:ACSL3
-inverse_is_a: HGNC:ACSL4
-inverse_is_a: HGNC:ACSL5
-inverse_is_a: HGNC:ACSL6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3569 ! ACSL1
+relationship: inverse_is_a HGNC:3570 ! ACSL3
+relationship: inverse_is_a HGNC:3571 ! ACSL4
+relationship: inverse_is_a HGNC:16526 ! ACSL5
+relationship: inverse_is_a HGNC:16496 ! ACSL6
 
 [Term]
-id: FPLX:Actin
+id: FPLX:000009
 name: Actin
 synonym: "actin filament" EXACT []
 synonym: "actin" EXACT []
@@ -131,17 +150,17 @@ xref: MESH:D000199
 xref: NCIT:C16258
 xref: NEXTPROT-FAMILY:00078
 xref: XFAM:PF00022
-is_a: FPLX:root
-inverse_is_a: HGNC:ACTA1
-inverse_is_a: HGNC:ACTA2
-inverse_is_a: HGNC:ACTB
-inverse_is_a: HGNC:ACTC1
-inverse_is_a: HGNC:ACTG1
-inverse_is_a: HGNC:ACTG2
-inverse_is_a: FPLX:F_actin
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:129 ! ACTA1
+relationship: inverse_is_a HGNC:130 ! ACTA2
+relationship: inverse_is_a HGNC:132 ! ACTB
+relationship: inverse_is_a HGNC:143 ! ACTC1
+relationship: inverse_is_a HGNC:144 ! ACTG1
+relationship: inverse_is_a HGNC:145 ! ACTG2
+relationship: inverse_is_a FPLX:000178 ! F_actin
 
 [Term]
-id: FPLX:Activin
+id: FPLX:000010
 name: Activin
 synonym: "activin protein" EXACT []
 synonym: "Activin" EXACT []
@@ -152,13 +171,13 @@ xref: NCIT:C20456
 xref: RE:R-HSA-2470478
 xref: RE:R-HSA-2470491
 xref: RE:R-HSA-2470494
-is_a: FPLX:root
-inverse_is_a: FPLX:Activin_A
-inverse_is_a: FPLX:Activin_AB
-inverse_is_a: FPLX:Activin_B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000011 ! Activin_A
+relationship: inverse_is_a FPLX:000012 ! Activin_AB
+relationship: inverse_is_a FPLX:000013 ! Activin_B
 
 [Term]
-id: FPLX:Activin_A
+id: FPLX:000011
 name: Activin-A
 synonym: "Activin A protein" EXACT []
 synonym: "Activin A" EXACT []
@@ -168,44 +187,44 @@ synonym: "activinA" EXACT []
 xref: GO:0043509
 xref: IP:IPR000491
 xref: RE:R-HSA-206893
-is_a: FPLX:Activin
-has_part: HGNC:INHBA
+is_a: FPLX:000010 ! Activin
+relationship: has_part HGNC:6066 ! INHBA
 
 [Term]
-id: FPLX:Activin_AB
+id: FPLX:000012
 name: Activin-AB
 synonym: "activin AB" EXACT []
 xref: RE:R-HSA-1449698
 xref: RE:R-HSA-2470478
 xref: RE:R-HSA-2470491
 xref: RE:R-HSA-2470494
-is_a: FPLX:Activin
-has_part: HGNC:INHBA
-has_part: HGNC:INHBB
+is_a: FPLX:000010 ! Activin
+relationship: has_part HGNC:6066 ! INHBA
+relationship: has_part HGNC:6067 ! INHBB
 
 [Term]
-id: FPLX:Activin_B
+id: FPLX:000013
 name: Activin-B
 synonym: "activin-B" EXACT []
 xref: IP:IPR000381
 xref: RE:R-HSA-1449672
-is_a: FPLX:Activin
-has_part: HGNC:INHBB
+is_a: FPLX:000010 ! Activin
+relationship: has_part HGNC:6067 ! INHBB
 
 [Term]
-id: FPLX:ACTN
+id: FPLX:000014
 name: ACTN
 synonym: "actinin" EXACT []
 xref: BEL:"ACTN Family"
 xref: RE:R-HSA-451402
-is_a: FPLX:root
-inverse_is_a: HGNC:ACTN1
-inverse_is_a: HGNC:ACTN2
-inverse_is_a: HGNC:ACTN3
-inverse_is_a: HGNC:ACTN4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:163 ! ACTN1
+relationship: inverse_is_a HGNC:164 ! ACTN2
+relationship: inverse_is_a HGNC:165 ! ACTN3
+relationship: inverse_is_a HGNC:166 ! ACTN4
 
 [Term]
-id: FPLX:Adaptor_protein_II
+id: FPLX:000015
 name: Adaptor-protein-II
 synonym: "Adaptor Protein 2 complex" EXACT []
 synonym: "adaptor protein complex 2" EXACT []
@@ -218,27 +237,27 @@ synonym: "AP2 complex" EXACT []
 synonym: "AP2" EXACT []
 xref: BEL:"Adaptor Protein II Complex"
 xref: GO:0030122
-is_a: FPLX:root
-has_part: HGNC:AP2B1
-has_part: HGNC:AP2M1
-has_part: HGNC:AP2S1
-has_part: FPLX:AP2A
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:563 ! AP2B1
+relationship: has_part HGNC:564 ! AP2M1
+relationship: has_part HGNC:565 ! AP2S1
+relationship: has_part FPLX:000049 ! AP2A
 
 [Term]
-id: FPLX:Adaptor_protein_III
+id: FPLX:000016
 name: Adaptor-protein-III
 synonym: "adaptor protein complex 3" EXACT []
 synonym: "AP-3" EXACT []
 synonym: "AP3" EXACT []
 xref: BEL:"Adaptor Protein III Complex"
-is_a: FPLX:root
-has_part: HGNC:AP3B1
-has_part: HGNC:AP3D1
-has_part: HGNC:AP3S1
-has_part: HGNC:AP3S2
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:566 ! AP3B1
+relationship: has_part HGNC:568 ! AP3D1
+relationship: has_part HGNC:2013 ! AP3S1
+relationship: has_part HGNC:571 ! AP3S2
 
 [Term]
-id: FPLX:ADCY
+id: FPLX:000017
 name: ADCY
 synonym: "adenylate cyclase" EXACT []
 synonym: "adenylyl cyclase" EXACT []
@@ -246,38 +265,38 @@ xref: BEL:"ADCY Family"
 xref: NCIT:C16264
 xref: RE:R-HSA-5610577
 xref: RE:R-HSA-5610578
-is_a: FPLX:root
-inverse_is_a: HGNC:ADCY1
-inverse_is_a: HGNC:ADCY2
-inverse_is_a: HGNC:ADCY3
-inverse_is_a: HGNC:ADCY4
-inverse_is_a: HGNC:ADCY5
-inverse_is_a: HGNC:ADCY6
-inverse_is_a: HGNC:ADCY7
-inverse_is_a: HGNC:ADCY8
-inverse_is_a: HGNC:ADCY9
-inverse_is_a: HGNC:ADCY10
-
-[Term]
-id: FPLX:ADH
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:232 ! ADCY1
+relationship: inverse_is_a HGNC:233 ! ADCY2
+relationship: inverse_is_a HGNC:234 ! ADCY3
+relationship: inverse_is_a HGNC:235 ! ADCY4
+relationship: inverse_is_a HGNC:236 ! ADCY5
+relationship: inverse_is_a HGNC:237 ! ADCY6
+relationship: inverse_is_a HGNC:238 ! ADCY7
+relationship: inverse_is_a HGNC:239 ! ADCY8
+relationship: inverse_is_a HGNC:240 ! ADCY9
+relationship: inverse_is_a HGNC:21285 ! ADCY10
+
+[Term]
+id: FPLX:000018
 name: ADH
 synonym: "alcohol dehydrogenase" EXACT []
 xref: BEL:"ADH Family"
 xref: ECCODE:1.1.1.1
 xref: NCIT:C16272
 xref: XFAM:PF00465
-is_a: FPLX:root
-inverse_is_a: HGNC:ADH1A
-inverse_is_a: HGNC:ADH1B
-inverse_is_a: HGNC:ADH1C
-inverse_is_a: HGNC:ADH4
-inverse_is_a: HGNC:ADH5
-inverse_is_a: HGNC:ADH6
-inverse_is_a: HGNC:ADH7
-inverse_is_a: HGNC:ADHFE1
-
-[Term]
-id: FPLX:ADRA
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:249 ! ADH1A
+relationship: inverse_is_a HGNC:250 ! ADH1B
+relationship: inverse_is_a HGNC:251 ! ADH1C
+relationship: inverse_is_a HGNC:252 ! ADH4
+relationship: inverse_is_a HGNC:253 ! ADH5
+relationship: inverse_is_a HGNC:255 ! ADH6
+relationship: inverse_is_a HGNC:256 ! ADH7
+relationship: inverse_is_a HGNC:16354 ! ADHFE1
+
+[Term]
+id: FPLX:000019
 name: ADRA
 synonym: "a-adrenoreceptor" EXACT []
 synonym: "alpha adrenoceptor" EXACT []
@@ -291,16 +310,16 @@ synonym: "α-adrenoreceptors" EXACT []
 xref: BEL:"ADRA Family"
 xref: GO:0004936
 xref: GO:0004937
-is_a: FPLX:root
-inverse_is_a: HGNC:ADRA1A
-inverse_is_a: HGNC:ADRA1B
-inverse_is_a: HGNC:ADRA1D
-inverse_is_a: HGNC:ADRA2A
-inverse_is_a: HGNC:ADRA2B
-inverse_is_a: HGNC:ADRA2C
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:277 ! ADRA1A
+relationship: inverse_is_a HGNC:278 ! ADRA1B
+relationship: inverse_is_a HGNC:280 ! ADRA1D
+relationship: inverse_is_a HGNC:281 ! ADRA2A
+relationship: inverse_is_a HGNC:282 ! ADRA2B
+relationship: inverse_is_a HGNC:283 ! ADRA2C
 
 [Term]
-id: FPLX:ADRA2
+id: FPLX:000020
 name: ADRA2
 synonym: "alpha(2)-adrenoceptors" EXACT []
 synonym: "alpha(2)-ARs" EXACT []
@@ -315,13 +334,13 @@ xref: BEL:"ADRA2 Family"
 xref: GO:0004938
 xref: RE:R-HSA-390664
 xref: RE:R-HSA-390700
-is_a: FPLX:root
-inverse_is_a: HGNC:ADRA2A
-inverse_is_a: HGNC:ADRA2B
-inverse_is_a: HGNC:ADRA2C
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:281 ! ADRA2A
+relationship: inverse_is_a HGNC:282 ! ADRA2B
+relationship: inverse_is_a HGNC:283 ! ADRA2C
 
 [Term]
-id: FPLX:ADRB
+id: FPLX:000021
 name: ADRB
 synonym: "b-adrenergic receptor" EXACT []
 synonym: "b-receptors" EXACT []
@@ -335,13 +354,13 @@ xref: BEL:"ADRB Family"
 xref: NCIT:C17062
 xref: RE:R-HSA-390643
 xref: RE:R-HSA-390670
-is_a: FPLX:root
-inverse_is_a: HGNC:ADRB1
-inverse_is_a: HGNC:ADRB2
-inverse_is_a: HGNC:ADRB3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:285 ! ADRB1
+relationship: inverse_is_a HGNC:286 ! ADRB2
+relationship: inverse_is_a HGNC:288 ! ADRB3
 
 [Term]
-id: FPLX:ADRBK
+id: FPLX:000022
 name: ADRBK
 synonym: "BARK" EXACT []
 synonym: "beta adrenergic receptor kinase" EXACT []
@@ -350,12 +369,12 @@ synonym: "β adrenergic receptor kinase" EXACT []
 synonym: "βARK" EXACT []
 xref: BEL:"ADRBK Family"
 xref: RE:R-HSA-8866229
-is_a: FPLX:GRK
-inverse_is_a: HGNC:GRK2
-inverse_is_a: HGNC:GRK3
+is_a: FPLX:000192 ! GRK
+relationship: inverse_is_a HGNC:289 ! GRK2
+relationship: inverse_is_a HGNC:290 ! GRK3
 
 [Term]
-id: FPLX:AKT
+id: FPLX:000023
 name: AKT
 synonym: "AKT family" EXACT []
 synonym: "AKT" EXACT []
@@ -376,13 +395,13 @@ xref: RE:R-HSA-2317329
 xref: RE:R-HSA-2400006
 xref: RE:R-HSA-2400013
 xref: SIGNOR:SIGNOR-PF24
-is_a: FPLX:root
-inverse_is_a: HGNC:AKT1
-inverse_is_a: HGNC:AKT2
-inverse_is_a: HGNC:AKT3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:391 ! AKT1
+relationship: inverse_is_a HGNC:392 ! AKT2
+relationship: inverse_is_a HGNC:393 ! AKT3
 
 [Term]
-id: FPLX:ALDH
+id: FPLX:000024
 name: ALDH
 synonym: "aldehyde dehydrogenase (NAD+)" EXACT []
 synonym: "Aldehyde dehydrogenase" EXACT []
@@ -391,20 +410,20 @@ synonym: "ALDH" EXACT []
 xref: BEL:"ALDH Family"
 xref: ECCODE:1.2.1.3
 xref: NCIT:C118481
-is_a: FPLX:root
-inverse_is_a: HGNC:ALDH1A1
-inverse_is_a: HGNC:ALDH1A2
-inverse_is_a: HGNC:ALDH1A3
-inverse_is_a: HGNC:ALDH2
-inverse_is_a: HGNC:ALDH3A1
-inverse_is_a: HGNC:ALDH3A2
-inverse_is_a: HGNC:ALDH3B1
-inverse_is_a: HGNC:ALDH5A1
-inverse_is_a: HGNC:ALDH7A1
-inverse_is_a: HGNC:ALDH9A1
-
-[Term]
-id: FPLX:ALDO
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:402 ! ALDH1A1
+relationship: inverse_is_a HGNC:15472 ! ALDH1A2
+relationship: inverse_is_a HGNC:409 ! ALDH1A3
+relationship: inverse_is_a HGNC:404 ! ALDH2
+relationship: inverse_is_a HGNC:405 ! ALDH3A1
+relationship: inverse_is_a HGNC:403 ! ALDH3A2
+relationship: inverse_is_a HGNC:410 ! ALDH3B1
+relationship: inverse_is_a HGNC:408 ! ALDH5A1
+relationship: inverse_is_a HGNC:877 ! ALDH7A1
+relationship: inverse_is_a HGNC:412 ! ALDH9A1
+
+[Term]
+id: FPLX:000025
 name: ALDO
 synonym: "ALDO" EXACT []
 synonym: "fructose-bisphosphate aldolase" EXACT []
@@ -413,54 +432,54 @@ xref: ECCODE:4.1.2.13
 xref: IP:IPR000741
 xref: IP:IPR029768
 xref: RE:R-HSA-179508
-is_a: FPLX:root
-inverse_is_a: HGNC:ALDOA
-inverse_is_a: HGNC:ALDOB
-inverse_is_a: HGNC:ALDOC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:414 ! ALDOA
+relationship: inverse_is_a HGNC:417 ! ALDOB
+relationship: inverse_is_a HGNC:418 ! ALDOC
 
 [Term]
-id: FPLX:ALG10
+id: FPLX:000026
 name: ALG10
 synonym: "ALG10" EXACT []
 synonym: "Alpha-1,2-glucosyltransferase" EXACT []
 synonym: "Alpha-1,2-glucosyltransferases" EXACT []
 synonym: "alpha-1,2-glucosyltransferase" EXACT []
 synonym: "alpha-1,2-glucosyltransferases" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ALG10
-inverse_is_a: HGNC:ALG10B
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:23162 ! ALG10
+relationship: inverse_is_a HGNC:31088 ! ALG10B
 
 [Term]
-id: FPLX:ALG1_family
+id: FPLX:000027
 name: ALG1-family
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ALG1
-inverse_is_a: HGNC:ALG1L
-inverse_is_a: HGNC:ALG1L2
-inverse_is_a: HGNC:ALG2
-inverse_is_a: HGNC:ALG11
-inverse_is_a: HGNC:GLT1D1
-inverse_is_a: HGNC:GTDC1
-inverse_is_a: HGNC:GYS1
-inverse_is_a: HGNC:GYS2
-inverse_is_a: HGNC:PIGA
-
-[Term]
-id: FPLX:ALG3_family
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:18294 ! ALG1
+relationship: inverse_is_a HGNC:33721 ! ALG1L
+relationship: inverse_is_a HGNC:37258 ! ALG1L2
+relationship: inverse_is_a HGNC:23159 ! ALG2
+relationship: inverse_is_a HGNC:32456 ! ALG11
+relationship: inverse_is_a HGNC:26483 ! GLT1D1
+relationship: inverse_is_a HGNC:20887 ! GTDC1
+relationship: inverse_is_a HGNC:4706 ! GYS1
+relationship: inverse_is_a HGNC:4707 ! GYS2
+relationship: inverse_is_a HGNC:8957 ! PIGA
+
+[Term]
+id: FPLX:000028
 name: ALG3-family
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ALG3
-inverse_is_a: HGNC:ALG9
-inverse_is_a: HGNC:ALG12
-inverse_is_a: HGNC:PIGB
-inverse_is_a: HGNC:PIGM
-inverse_is_a: HGNC:PIGV
-inverse_is_a: HGNC:PIGZ
-inverse_is_a: HGNC:POMT1
-inverse_is_a: HGNC:POMT2
-
-[Term]
-id: FPLX:ALG6_family
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:23056 ! ALG3
+relationship: inverse_is_a HGNC:15672 ! ALG9
+relationship: inverse_is_a HGNC:19358 ! ALG12
+relationship: inverse_is_a HGNC:8959 ! PIGB
+relationship: inverse_is_a HGNC:18858 ! PIGM
+relationship: inverse_is_a HGNC:26031 ! PIGV
+relationship: inverse_is_a HGNC:30596 ! PIGZ
+relationship: inverse_is_a HGNC:9202 ! POMT1
+relationship: inverse_is_a HGNC:19743 ! POMT2
+
+[Term]
+id: FPLX:000029
 name: ALG6-family
 synonym: "Alpha-1,3-glucosyltransferase" EXACT []
 synonym: "Alpha-1,3-glucosyltransferases" EXACT []
@@ -470,19 +489,19 @@ synonym: "Alpha-1,4-glucosyltransferase" EXACT []
 synonym: "Alpha-1,4-glucosyltransferases" EXACT []
 synonym: "alpha-1,4-glucosyltransferase" EXACT []
 synonym: "alpha-1,4-glucosyltransferases" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ALG6
-inverse_is_a: HGNC:ALG8
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:23157 ! ALG6
+relationship: inverse_is_a HGNC:23161 ! ALG8
 
 [Term]
-id: FPLX:ALG13_family
+id: FPLX:000030
 name: ALG13-family
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ALG13
-inverse_is_a: HGNC:ALG14
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:30881 ! ALG13
+relationship: inverse_is_a HGNC:28287 ! ALG14
 
 [Term]
-id: FPLX:AMPK
+id: FPLX:000031
 name: AMPK
 synonym: "AMPK" EXACT []
 xref: BEL:"AMP Activated Protein Kinase Complex"
@@ -494,25 +513,25 @@ xref: RE:R-HSA-380931
 xref: RE:R-HSA-380934
 xref: RE:R-HSA-380961
 xref: RE:R-HSA-6805467
-is_a: FPLX:root
-inverse_is_a: FPLX:AMPK_A1B1G1
-inverse_is_a: FPLX:AMPK_A1B1G2
-inverse_is_a: FPLX:AMPK_A1B1G3
-inverse_is_a: FPLX:AMPK_A1B2G1
-inverse_is_a: FPLX:AMPK_A1B2G2
-inverse_is_a: FPLX:AMPK_A1B2G3
-inverse_is_a: FPLX:AMPK_A2B1G1
-inverse_is_a: FPLX:AMPK_A2B1G2
-inverse_is_a: FPLX:AMPK_A2B1G3
-inverse_is_a: FPLX:AMPK_A2B2G1
-inverse_is_a: FPLX:AMPK_A2B2G2
-inverse_is_a: FPLX:AMPK_A2B2G3
-has_part: FPLX:AMPK_alpha
-has_part: FPLX:AMPK_beta
-has_part: FPLX:AMPK_gamma
-
-[Term]
-id: FPLX:AMPK_A1B1G1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000032 ! AMPK_A1B1G1
+relationship: inverse_is_a FPLX:000033 ! AMPK_A1B1G2
+relationship: inverse_is_a FPLX:000034 ! AMPK_A1B1G3
+relationship: inverse_is_a FPLX:000035 ! AMPK_A1B2G1
+relationship: inverse_is_a FPLX:000036 ! AMPK_A1B2G2
+relationship: inverse_is_a FPLX:000037 ! AMPK_A1B2G3
+relationship: inverse_is_a FPLX:000038 ! AMPK_A2B1G1
+relationship: inverse_is_a FPLX:000039 ! AMPK_A2B1G2
+relationship: inverse_is_a FPLX:000040 ! AMPK_A2B1G3
+relationship: inverse_is_a FPLX:000041 ! AMPK_A2B2G1
+relationship: inverse_is_a FPLX:000042 ! AMPK_A2B2G2
+relationship: inverse_is_a FPLX:000043 ! AMPK_A2B2G3
+relationship: has_part FPLX:000044 ! AMPK_alpha
+relationship: has_part FPLX:000045 ! AMPK_beta
+relationship: has_part FPLX:000046 ! AMPK_gamma
+
+[Term]
+id: FPLX:000032
 name: AMPK-A1B1G1
 synonym: "AMPK (alpha 1, beta 1, gamma 1)" EXACT []
 synonym: "AMPK (α 1, β 1, γ 1)" EXACT []
@@ -522,13 +541,13 @@ synonym: "AMPK a1b1g1" EXACT []
 synonym: "AMPK alpha1beta1gamma1" EXACT []
 synonym: "AMPK α1β1γ1" EXACT []
 synonym: "α1β1γ1" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA1
-has_part: HGNC:PRKAB1
-has_part: HGNC:PRKAG1
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9385 ! PRKAG1
 
 [Term]
-id: FPLX:AMPK_A1B1G2
+id: FPLX:000033
 name: AMPK-A1B1G2
 synonym: "AMPK (alpha 1, beta 1, gamma 2)" EXACT []
 synonym: "AMPK (α 1, β 1, γ 2)" EXACT []
@@ -538,13 +557,13 @@ synonym: "AMPK a1b1g2" EXACT []
 synonym: "AMPK alpha1beta1gamma2" EXACT []
 synonym: "AMPK α1β1γ2" EXACT []
 synonym: "α1β1γ2" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA1
-has_part: HGNC:PRKAB1
-has_part: HGNC:PRKAG2
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9386 ! PRKAG2
 
 [Term]
-id: FPLX:AMPK_A1B1G3
+id: FPLX:000034
 name: AMPK-A1B1G3
 synonym: "AMPK (alpha 1, beta 1, gamma 3)" EXACT []
 synonym: "AMPK (α 1, β 1, γ 3)" EXACT []
@@ -554,13 +573,13 @@ synonym: "AMPK a1b1g3" EXACT []
 synonym: "AMPK alpha1beta1gamma3" EXACT []
 synonym: "AMPK α1β1γ3" EXACT []
 synonym: "α1β1γ3" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA1
-has_part: HGNC:PRKAB1
-has_part: HGNC:PRKAG3
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9387 ! PRKAG3
 
 [Term]
-id: FPLX:AMPK_A1B2G1
+id: FPLX:000035
 name: AMPK-A1B2G1
 synonym: "AMPK (alpha 1, beta 2, gamma 1)" EXACT []
 synonym: "AMPK (α 1, β 2, γ 1)" EXACT []
@@ -570,13 +589,13 @@ synonym: "AMPK a1b2g1" EXACT []
 synonym: "AMPK alpha1beta2gamma1" EXACT []
 synonym: "AMPK α1β2γ1" EXACT []
 synonym: "α1β2γ1" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA1
-has_part: HGNC:PRKAB2
-has_part: HGNC:PRKAG1
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9385 ! PRKAG1
 
 [Term]
-id: FPLX:AMPK_A1B2G2
+id: FPLX:000036
 name: AMPK-A1B2G2
 synonym: "AMPK (alpha 1, beta 2, gamma 2)" EXACT []
 synonym: "AMPK (α 1, β 2, γ 2)" EXACT []
@@ -586,26 +605,26 @@ synonym: "AMPK a1b2g2" EXACT []
 synonym: "AMPK alpha1beta2gamma2" EXACT []
 synonym: "AMPK α1β2γ2" EXACT []
 synonym: "α1β2γ2" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA1
-has_part: HGNC:PRKAB2
-has_part: HGNC:PRKAG2
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9386 ! PRKAG2
 
 [Term]
-id: FPLX:AMPK_A1B2G3
+id: FPLX:000037
 name: AMPK-A1B2G3
 synonym: "AMPK (alpha 1, beta 2, gamma 3)" EXACT []
 synonym: "AMPK (α 1, β 2, γ 3)" EXACT []
 synonym: "AMPK (A1/B2/G3)" EXACT []
 synonym: "AMPK alpha1beta2gamma3" EXACT []
 synonym: "AMPK α1β2γ3" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA1
-has_part: HGNC:PRKAB2
-has_part: HGNC:PRKAG3
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9387 ! PRKAG3
 
 [Term]
-id: FPLX:AMPK_A2B1G1
+id: FPLX:000038
 name: AMPK-A2B1G1
 synonym: "AMPK (alpha 2, beta 1, gamma 1)" EXACT []
 synonym: "AMPK (α 2, β 1, γ 1)" EXACT []
@@ -615,39 +634,39 @@ synonym: "AMPK a2b1g1" EXACT []
 synonym: "AMPK alpha2beta1gamma1" EXACT []
 synonym: "AMPK α2β1γ1" EXACT []
 synonym: "α2β1γ1" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA2
-has_part: HGNC:PRKAB1
-has_part: HGNC:PRKAG1
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9385 ! PRKAG1
 
 [Term]
-id: FPLX:AMPK_A2B1G2
+id: FPLX:000039
 name: AMPK-A2B1G2
 synonym: "AMPK (alpha 2, beta 1, gamma 2)" EXACT []
 synonym: "AMPK (α 2, β 1, γ 2)" EXACT []
 synonym: "AMPK (A2/B1/G2)" EXACT []
 synonym: "AMPK alpha2beta1gamma2" EXACT []
 synonym: "AMPK α2β1γ2" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA2
-has_part: HGNC:PRKAB1
-has_part: HGNC:PRKAG2
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9386 ! PRKAG2
 
 [Term]
-id: FPLX:AMPK_A2B1G3
+id: FPLX:000040
 name: AMPK-A2B1G3
 synonym: "AMPK (alpha 2, beta 1, gamma 3)" EXACT []
 synonym: "AMPK (α 2, β 1, γ 3)" EXACT []
 synonym: "AMPK (A2/B1/G3)" EXACT []
 synonym: "AMPK alpha2beta1gamma3" EXACT []
 synonym: "AMPK α2β1γ3" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA2
-has_part: HGNC:PRKAB1
-has_part: HGNC:PRKAG3
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9387 ! PRKAG3
 
 [Term]
-id: FPLX:AMPK_A2B2G1
+id: FPLX:000041
 name: AMPK-A2B2G1
 synonym: "AMPK (alpha 2, beta 2, gamma 1)" EXACT []
 synonym: "AMPK (α 2, β 2, γ 1)" EXACT []
@@ -657,13 +676,13 @@ synonym: "AMPK a2b2g1" EXACT []
 synonym: "AMPK alpha2beta2gamma1" EXACT []
 synonym: "AMPK α2β2γ1" EXACT []
 synonym: "α2β2γ1" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA2
-has_part: HGNC:PRKAB2
-has_part: HGNC:PRKAG1
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9385 ! PRKAG1
 
 [Term]
-id: FPLX:AMPK_A2B2G2
+id: FPLX:000042
 name: AMPK-A2B2G2
 synonym: "AMPK (alpha 2, beta 2, gamma 2)" EXACT []
 synonym: "AMPK (α 2, β 2, γ 2)" EXACT []
@@ -677,13 +696,13 @@ xref: RE:R-HSA-163679
 xref: RE:R-HSA-163736
 xref: RE:R-HSA-163747
 xref: RE:R-HSA-200408
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA2
-has_part: HGNC:PRKAB2
-has_part: HGNC:PRKAG2
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9386 ! PRKAG2
 
 [Term]
-id: FPLX:AMPK_A2B2G3
+id: FPLX:000043
 name: AMPK-A2B2G3
 synonym: "AMPK (alpha 2, beta 2, gamma 3)" EXACT []
 synonym: "AMPK (α 2, β 2, γ 3)" EXACT []
@@ -693,13 +712,13 @@ synonym: "AMPK a2b2g3" EXACT []
 synonym: "AMPK alpha2beta2gamma3" EXACT []
 synonym: "AMPK α2β2γ3" EXACT []
 synonym: "α2β2γ3" EXACT []
-is_a: FPLX:AMPK
-has_part: HGNC:PRKAA2
-has_part: HGNC:PRKAB2
-has_part: HGNC:PRKAG3
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9387 ! PRKAG3
 
 [Term]
-id: FPLX:AMPK_alpha
+id: FPLX:000044
 name: AMPK-alpha
 synonym: "AMPKalpha" EXACT []
 synonym: "AMPKα" EXACT []
@@ -711,12 +730,12 @@ xref: RE:R-HSA-2151213
 xref: RE:R-HSA-381844
 xref: RE:R-HSA-381845
 xref: SIGNOR:SIGNOR-PF6
-part_of: FPLX:AMPK
-inverse_is_a: HGNC:PRKAA1
-inverse_is_a: HGNC:PRKAA2
+relationship: part_of FPLX:000031 ! AMPK
+relationship: inverse_is_a HGNC:9376 ! PRKAA1
+relationship: inverse_is_a HGNC:9377 ! PRKAA2
 
 [Term]
-id: FPLX:AMPK_beta
+id: FPLX:000045
 name: AMPK-beta
 synonym: "PRKAB" EXACT []
 xref: BEL:"PRKAB Family"
@@ -724,25 +743,25 @@ xref: IP:IPR006828
 xref: IP:IPR032640
 xref: RE:R-HSA-2151208
 xref: RE:R-HSA-381854
-part_of: FPLX:AMPK
-inverse_is_a: HGNC:PRKAB1
-inverse_is_a: HGNC:PRKAB2
+relationship: part_of FPLX:000031 ! AMPK
+relationship: inverse_is_a HGNC:9378 ! PRKAB1
+relationship: inverse_is_a HGNC:9379 ! PRKAB2
 
 [Term]
-id: FPLX:AMPK_gamma
+id: FPLX:000046
 name: AMPK-gamma
 synonym: "PRKAG" EXACT []
 xref: BEL:"PRKAG Family"
 xref: RE:R-HSA-2151212
 xref: RE:R-HSA-2316451
 xref: RE:R-HSA-381851
-part_of: FPLX:AMPK
-inverse_is_a: HGNC:PRKAG1
-inverse_is_a: HGNC:PRKAG2
-inverse_is_a: HGNC:PRKAG3
+relationship: part_of FPLX:000031 ! AMPK
+relationship: inverse_is_a HGNC:9385 ! PRKAG1
+relationship: inverse_is_a HGNC:9386 ! PRKAG2
+relationship: inverse_is_a HGNC:9387 ! PRKAG3
 
 [Term]
-id: FPLX:Annexin_II_heterotetramer
+id: FPLX:000047
 name: Annexin-II-heterotetramer
 synonym: "A2t" EXACT []
 synonym: "annexin A2 heterotetramer" EXACT []
@@ -750,55 +769,55 @@ synonym: "annexin II heterotetramer" EXACT []
 synonym: "ANXA2 heterotetramer" EXACT []
 xref: BEL:"Annexin II Heterotetramer Complex"
 xref: RE:R-HSA-5336141
-is_a: FPLX:root
-has_part: HGNC:ANXA2
-has_part: HGNC:S100A10
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:537 ! ANXA2
+relationship: has_part HGNC:10487 ! S100A10
 
 [Term]
-id: FPLX:AP1
+id: FPLX:000048
 name: AP1
 synonym: "AP-1" EXACT []
 synonym: "AP1" EXACT []
 xref: BEL:"AP-1 Complex"
 xref: MESH:D018808
 xref: NCIT:C17450
-is_a: FPLX:root
-has_part: FPLX:FOS_family
-has_part: FPLX:JUN_family
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000173 ! FOS_family
+relationship: has_part FPLX:000268 ! JUN_family
 
 [Term]
-id: FPLX:AP2A
+id: FPLX:000049
 name: AP2A
 xref: IP:IPR017104
-part_of: FPLX:Adaptor_protein_II
-inverse_is_a: HGNC:AP2A1
-inverse_is_a: HGNC:AP2A2
+relationship: part_of FPLX:000015 ! Adaptor_protein_II
+relationship: inverse_is_a HGNC:561 ! AP2A1
+relationship: inverse_is_a HGNC:562 ! AP2A2
 
 [Term]
-id: FPLX:APC_C
+id: FPLX:000050
 name: APC-C
 synonym: "APC/C" EXACT []
 xref: GO:0005680
 xref: MEDSCAN:urn:agi-aopfc:0000571
 xref: MEDSCAN:urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35
-is_a: FPLX:root
-has_part: HGNC:ANAPC2
-has_part: HGNC:ANAPC11
-has_part: HGNC:ANAPC1
-has_part: HGNC:CDC16
-has_part: HGNC:CDC27
-has_part: HGNC:CDC23
-has_part: HGNC:ANAPC5
-has_part: HGNC:ANAPC10
-has_part: HGNC:ANAPC15
-has_part: HGNC:ANAPC13
-has_part: HGNC:CDC26
-has_part: HGNC:ANAPC16
-has_part: HGNC:ANAPC7
-has_part: HGNC:ANAPC4
-
-[Term]
-id: FPLX:APOA
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:19989 ! ANAPC2
+relationship: has_part HGNC:14452 ! ANAPC11
+relationship: has_part HGNC:19988 ! ANAPC1
+relationship: has_part HGNC:1720 ! CDC16
+relationship: has_part HGNC:1728 ! CDC27
+relationship: has_part HGNC:1724 ! CDC23
+relationship: has_part HGNC:15713 ! ANAPC5
+relationship: has_part HGNC:24077 ! ANAPC10
+relationship: has_part HGNC:24531 ! ANAPC15
+relationship: has_part HGNC:24540 ! ANAPC13
+relationship: has_part HGNC:17839 ! CDC26
+relationship: has_part HGNC:26976 ! ANAPC16
+relationship: has_part HGNC:17380 ! ANAPC7
+relationship: has_part HGNC:19990 ! ANAPC4
+
+[Term]
+id: FPLX:000051
 name: APOA
 synonym: "ApoA" EXACT []
 synonym: "apoA" EXACT []
@@ -808,14 +827,14 @@ synonym: "apolipoprotein(A)" EXACT []
 synonym: "apolipoprotein(a)" EXACT []
 xref: BEL:"APOA Family"
 xref: NCIT:C105952
-is_a: FPLX:Apolipoprotein
-inverse_is_a: HGNC:APOA1
-inverse_is_a: HGNC:APOA2
-inverse_is_a: HGNC:APOA4
-inverse_is_a: HGNC:APOA5
+is_a: FPLX:000052 ! Apolipoprotein
+relationship: inverse_is_a HGNC:600 ! APOA1
+relationship: inverse_is_a HGNC:601 ! APOA2
+relationship: inverse_is_a HGNC:602 ! APOA4
+relationship: inverse_is_a HGNC:17288 ! APOA5
 
 [Term]
-id: FPLX:Apolipoprotein
+id: FPLX:000052
 name: Apolipoprotein
 synonym: "Apolipoprotein" EXACT []
 synonym: "apolipoprotein" EXACT []
@@ -823,87 +842,87 @@ synonym: "apolipoproteins" EXACT []
 xref: IP:IPR000074
 xref: MEDSCAN:urn:agi-protfc:apolipoprotein
 xref: XFAM:PF01442
-is_a: FPLX:root
-inverse_is_a: FPLX:APOA
-inverse_is_a: HGNC:APOE
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000051 ! APOA
+relationship: inverse_is_a HGNC:613 ! APOE
 
 [Term]
-id: FPLX:ARF_GTPase_family
+id: FPLX:000053
 name: ARF-GTPase-family
 synonym: "ADP ribosylation factor" EXACT []
 synonym: "ARF" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:TRIM23
-inverse_is_a: HGNC:ARF1
-inverse_is_a: HGNC:ARF3
-inverse_is_a: HGNC:ARF4
-inverse_is_a: HGNC:ARF5
-inverse_is_a: HGNC:ARF6
-inverse_is_a: HGNC:ARL1
-inverse_is_a: HGNC:ARL2
-inverse_is_a: HGNC:ARL3
-inverse_is_a: HGNC:ARL4A
-inverse_is_a: HGNC:ARL4C
-inverse_is_a: HGNC:ARL4D
-inverse_is_a: HGNC:ARL5A
-inverse_is_a: HGNC:ARL5B
-inverse_is_a: HGNC:ARL5C
-inverse_is_a: HGNC:ARL6
-inverse_is_a: HGNC:ARL8A
-inverse_is_a: HGNC:ARL8B
-inverse_is_a: HGNC:ARL9
-inverse_is_a: HGNC:ARL10
-inverse_is_a: HGNC:ARL11
-inverse_is_a: HGNC:ARL13A
-inverse_is_a: HGNC:ARL13B
-inverse_is_a: HGNC:ARL14
-inverse_is_a: HGNC:ARL15
-inverse_is_a: HGNC:ARL16
-inverse_is_a: HGNC:ARL17A
-inverse_is_a: HGNC:ARL17B
-inverse_is_a: HGNC:ARFRP1
-inverse_is_a: HGNC:SAR1A
-inverse_is_a: HGNC:SAR1B
-
-[Term]
-id: FPLX:Arp2_3_protein
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:660 ! TRIM23
+relationship: inverse_is_a HGNC:652 ! ARF1
+relationship: inverse_is_a HGNC:654 ! ARF3
+relationship: inverse_is_a HGNC:655 ! ARF4
+relationship: inverse_is_a HGNC:658 ! ARF5
+relationship: inverse_is_a HGNC:659 ! ARF6
+relationship: inverse_is_a HGNC:692 ! ARL1
+relationship: inverse_is_a HGNC:693 ! ARL2
+relationship: inverse_is_a HGNC:694 ! ARL3
+relationship: inverse_is_a HGNC:695 ! ARL4A
+relationship: inverse_is_a HGNC:698 ! ARL4C
+relationship: inverse_is_a HGNC:656 ! ARL4D
+relationship: inverse_is_a HGNC:696 ! ARL5A
+relationship: inverse_is_a HGNC:23052 ! ARL5B
+relationship: inverse_is_a HGNC:31111 ! ARL5C
+relationship: inverse_is_a HGNC:13210 ! ARL6
+relationship: inverse_is_a HGNC:25192 ! ARL8A
+relationship: inverse_is_a HGNC:25564 ! ARL8B
+relationship: inverse_is_a HGNC:23592 ! ARL9
+relationship: inverse_is_a HGNC:22042 ! ARL10
+relationship: inverse_is_a HGNC:24046 ! ARL11
+relationship: inverse_is_a HGNC:31709 ! ARL13A
+relationship: inverse_is_a HGNC:25419 ! ARL13B
+relationship: inverse_is_a HGNC:22974 ! ARL14
+relationship: inverse_is_a HGNC:25945 ! ARL15
+relationship: inverse_is_a HGNC:27902 ! ARL16
+relationship: inverse_is_a HGNC:24096 ! ARL17A
+relationship: inverse_is_a HGNC:32387 ! ARL17B
+relationship: inverse_is_a HGNC:662 ! ARFRP1
+relationship: inverse_is_a HGNC:10534 ! SAR1A
+relationship: inverse_is_a HGNC:10535 ! SAR1B
+
+[Term]
+id: FPLX:000054
 name: Arp2-3-protein
 synonym: "Arp2/3" EXACT []
 xref: BEL:"Arp2/3 Protein Complex"
-is_a: FPLX:root
-has_part: HGNC:ARPC1A
-has_part: HGNC:ARPC1B
-has_part: HGNC:ARPC2
-has_part: HGNC:ARPC3
-has_part: HGNC:ARPC4
-has_part: HGNC:ARPC5
-has_part: HGNC:ARPC5L
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:703 ! ARPC1A
+relationship: has_part HGNC:704 ! ARPC1B
+relationship: has_part HGNC:705 ! ARPC2
+relationship: has_part HGNC:706 ! ARPC3
+relationship: has_part HGNC:707 ! ARPC4
+relationship: has_part HGNC:708 ! ARPC5
+relationship: has_part HGNC:23366 ! ARPC5L
 
 [Term]
-id: FPLX:ARRB
+id: FPLX:000055
 name: ARRB
 synonym: "b-arrestin" EXACT []
 synonym: "barrestins" EXACT []
 xref: BEL:"ARRB Family"
 xref: RE:R-HSA-1911410
-is_a: FPLX:root
-inverse_is_a: HGNC:ARRB1
-inverse_is_a: HGNC:ARRB2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:711 ! ARRB1
+relationship: inverse_is_a HGNC:712 ! ARRB2
 
 [Term]
-id: FPLX:ATG4
+id: FPLX:000056
 name: ATG4
 synonym: "ATG4" EXACT []
 synonym: "Atg4" EXACT []
 xref: RE:R-HSA-5682664
-is_a: FPLX:root
-inverse_is_a: HGNC:ATG4A
-inverse_is_a: HGNC:ATG4B
-inverse_is_a: HGNC:ATG4C
-inverse_is_a: HGNC:ATG4D
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:16489 ! ATG4A
+relationship: inverse_is_a HGNC:20790 ! ATG4B
+relationship: inverse_is_a HGNC:16040 ! ATG4C
+relationship: inverse_is_a HGNC:20789 ! ATG4D
 
 [Term]
-id: FPLX:ATP1A
+id: FPLX:000057
 name: ATP1A
 synonym: "ATP1A" EXACT []
 synonym: "ATPase Na+/K+ transporting subunit alpha" EXACT []
@@ -913,64 +932,64 @@ synonym: "ATPase Na+/K+ transporting subunit β" EXACT []
 synonym: "Na/K ATPase alpha" EXACT []
 synonym: "Na/K ATPase α" EXACT []
 xref: RE:R-HSA-936779
-part_of: FPLX:Na_K_ATPase
-inverse_is_a: HGNC:ATP1A1
-inverse_is_a: HGNC:ATP1A2
-inverse_is_a: HGNC:ATP1A3
-inverse_is_a: HGNC:ATP1A4
+relationship: part_of FPLX:000303 ! Na_K_ATPase
+relationship: inverse_is_a HGNC:799 ! ATP1A1
+relationship: inverse_is_a HGNC:800 ! ATP1A2
+relationship: inverse_is_a HGNC:801 ! ATP1A3
+relationship: inverse_is_a HGNC:14073 ! ATP1A4
 
 [Term]
-id: FPLX:ATP1B
+id: FPLX:000058
 name: ATP1B
 synonym: "Na,K-ATPase beta subunit" EXACT []
 synonym: "Na,K-ATPase β subunit" EXACT []
 synonym: "ATP1B" EXACT []
 xref: RE:R-HSA-936820
-part_of: FPLX:Na_K_ATPase
-inverse_is_a: HGNC:ATP1B1
-inverse_is_a: HGNC:ATP1B2
-inverse_is_a: HGNC:ATP1B3
-inverse_is_a: HGNC:ATP1B4
+relationship: part_of FPLX:000303 ! Na_K_ATPase
+relationship: inverse_is_a HGNC:804 ! ATP1B1
+relationship: inverse_is_a HGNC:805 ! ATP1B2
+relationship: inverse_is_a HGNC:806 ! ATP1B3
+relationship: inverse_is_a HGNC:808 ! ATP1B4
 
 [Term]
-id: FPLX:ATP5G
+id: FPLX:000059
 name: ATP5G
 synonym: "ATP synthase H + transporting mitochondrial F0 complex subunit G" EXACT []
 xref: BEL:"ATP5G Family"
 xref: IP:IPR000454
 xref: IP:IPR020537
-part_of: FPLX:ATP_synthase
-inverse_is_a: HGNC:ATP5MC1
-inverse_is_a: HGNC:ATP5MC2
-inverse_is_a: HGNC:ATP5MC3
+relationship: part_of FPLX:000060 ! ATP_synthase
+relationship: inverse_is_a HGNC:841 ! ATP5MC1
+relationship: inverse_is_a HGNC:842 ! ATP5MC2
+relationship: inverse_is_a HGNC:843 ! ATP5MC3
 
 [Term]
-id: FPLX:ATP_synthase
+id: FPLX:000060
 name: ATP-synthase
 synonym: "ATP synthase" EXACT []
 xref: BEL:"Proton Transporting ATP Synthase Complex"
-is_a: FPLX:root
-has_part: HGNC:ATP5F1A
-has_part: HGNC:ATP5F1B
-has_part: HGNC:ATP5F1C
-has_part: HGNC:ATP5F1D
-has_part: HGNC:ATP5F1E
-has_part: HGNC:ATP5MD
-has_part: HGNC:ATP5ME
-has_part: HGNC:ATP5MF
-has_part: HGNC:ATP5MG
-has_part: HGNC:ATP5MPL
-has_part: HGNC:MT-ATP6
-has_part: HGNC:MT-ATP8
-has_part: HGNC:ATP5PB
-has_part: HGNC:ATP5PD
-has_part: HGNC:ATP5PF
-has_part: HGNC:ATP5PO
-has_part: HGNC:ATP5IF1
-has_part: FPLX:ATP5G
-
-[Term]
-id: FPLX:Augmin
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:823 ! ATP5F1A
+relationship: has_part HGNC:830 ! ATP5F1B
+relationship: has_part HGNC:833 ! ATP5F1C
+relationship: has_part HGNC:837 ! ATP5F1D
+relationship: has_part HGNC:838 ! ATP5F1E
+relationship: has_part HGNC:30889 ! ATP5MD
+relationship: has_part HGNC:846 ! ATP5ME
+relationship: has_part HGNC:848 ! ATP5MF
+relationship: has_part HGNC:14247 ! ATP5MG
+relationship: has_part HGNC:1188 ! ATP5MPL
+relationship: has_part HGNC:7414 ! MT-ATP6
+relationship: has_part HGNC:7415 ! MT-ATP8
+relationship: has_part HGNC:840 ! ATP5PB
+relationship: has_part HGNC:845 ! ATP5PD
+relationship: has_part HGNC:847 ! ATP5PF
+relationship: has_part HGNC:850 ! ATP5PO
+relationship: has_part HGNC:871 ! ATP5IF1
+relationship: has_part FPLX:000059 ! ATP5G
+
+[Term]
+id: FPLX:000061
 name: Augmin
 synonym: "Augmin" EXACT []
 synonym: "HAUS" EXACT []
@@ -978,18 +997,18 @@ synonym: "HAUS complex" EXACT []
 xref: GO:0070652
 xref: HGNC_GROUP:581
 xref: RE:R-HSA-8855211
-is_a: FPLX:root
-has_part: HGNC:HAUS1
-has_part: HGNC:HAUS2
-has_part: HGNC:HAUS3
-has_part: HGNC:HAUS4
-has_part: HGNC:HAUS5
-has_part: HGNC:HAUS6
-has_part: HGNC:HAUS7
-has_part: HGNC:HAUS8
-
-[Term]
-id: FPLX:AXIN
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:25174 ! HAUS1
+relationship: has_part HGNC:25530 ! HAUS2
+relationship: has_part HGNC:28719 ! HAUS3
+relationship: has_part HGNC:20163 ! HAUS4
+relationship: has_part HGNC:29130 ! HAUS5
+relationship: has_part HGNC:25948 ! HAUS6
+relationship: has_part HGNC:32979 ! HAUS7
+relationship: has_part HGNC:30532 ! HAUS8
+
+[Term]
+id: FPLX:000062
 name: AXIN
 synonym: "Axin" EXACT []
 synonym: "hAxin" EXACT []
@@ -1000,25 +1019,25 @@ xref: RE:R-HSA-3640819
 xref: RE:R-HSA-3640863
 xref: RE:R-HSA-3772502
 xref: RE:R-HSA-4641132
-is_a: FPLX:root
-inverse_is_a: HGNC:AXIN1
-inverse_is_a: HGNC:AXIN2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:903 ! AXIN1
+relationship: inverse_is_a HGNC:904 ! AXIN2
 
 [Term]
-id: FPLX:B3GAT
+id: FPLX:000063
 name: B3GAT
 synonym: "B3GAT" EXACT []
 synonym: "Beta-1,3-glucuronyltransferase" EXACT []
 synonym: "Beta-1,3-glucuronyltransferases" EXACT []
 synonym: "beta-1,3-glucuronyltransferase" EXACT []
 synonym: "beta-1,3-glucuronyltransferases" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:B3GAT1
-inverse_is_a: HGNC:B3GAT2
-inverse_is_a: HGNC:B3GAT3
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:921 ! B3GAT1
+relationship: inverse_is_a HGNC:922 ! B3GAT2
+relationship: inverse_is_a HGNC:923 ! B3GAT3
 
 [Term]
-id: FPLX:BCKDC
+id: FPLX:000064
 name: BCKDC
 synonym: "BCKDC" EXACT []
 synonym: "BCKDH" EXACT []
@@ -1030,14 +1049,14 @@ xref: BEL:"Branched Chain Alpha Keto Acid Dehydrogenase Complex"
 xref: RE:R-HSA-5693120
 xref: RE:R-HSA-6792583
 xref: RE:R-HSA-70019
-is_a: FPLX:root
-has_part: HGNC:BCKDHA
-has_part: HGNC:BCKDHB
-has_part: HGNC:DBT
-has_part: HGNC:DLD
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:986 ! BCKDHA
+relationship: has_part HGNC:987 ! BCKDHB
+relationship: has_part HGNC:2698 ! DBT
+relationship: has_part HGNC:2898 ! DLD
 
 [Term]
-id: FPLX:Beta_3_4_GTF
+id: FPLX:000065
 name: Beta-3-4-GTF
 synonym: "Beta 3-glycosyltransferase" EXACT []
 synonym: "Beta 3-glycosyltransferases" EXACT []
@@ -1047,97 +1066,97 @@ synonym: "Beta 4-glycosyltransferase" EXACT []
 synonym: "Beta 4-glycosyltransferases" EXACT []
 synonym: "beta 4-glycosyltransferase" EXACT []
 synonym: "beta 4-glycosyltransferases" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:B3GALNT1
-inverse_is_a: HGNC:B3GALNT2
-inverse_is_a: HGNC:B3GLCT
-inverse_is_a: HGNC:B3GALT1
-inverse_is_a: HGNC:B3GALT2
-inverse_is_a: HGNC:B3GALT4
-inverse_is_a: HGNC:B3GALT5
-inverse_is_a: HGNC:B3GALT6
-inverse_is_a: HGNC:B3GNT2
-inverse_is_a: HGNC:B3GNT3
-inverse_is_a: HGNC:B3GNT4
-inverse_is_a: HGNC:B3GNT5
-inverse_is_a: HGNC:B3GNT6
-inverse_is_a: HGNC:B3GNT7
-inverse_is_a: HGNC:B3GNT8
-inverse_is_a: HGNC:B3GNT9
-inverse_is_a: HGNC:CHPF
-inverse_is_a: HGNC:CHPF2
-inverse_is_a: HGNC:CHSY1
-inverse_is_a: HGNC:CHSY3
-inverse_is_a: HGNC:C1GALT1
-inverse_is_a: HGNC:LFNG
-inverse_is_a: HGNC:MFNG
-inverse_is_a: HGNC:RFNG
-inverse_is_a: HGNC:B4GALNT1
-inverse_is_a: HGNC:B4GALNT2
-inverse_is_a: HGNC:B4GALNT3
-inverse_is_a: HGNC:B4GALNT4
-inverse_is_a: HGNC:B4GALT1
-inverse_is_a: HGNC:B4GALT2
-inverse_is_a: HGNC:B4GALT3
-inverse_is_a: HGNC:B4GALT4
-inverse_is_a: HGNC:B4GALT5
-inverse_is_a: HGNC:B4GALT6
-inverse_is_a: HGNC:B4GALT7
-inverse_is_a: HGNC:CSGALNACT1
-inverse_is_a: HGNC:CSGALNACT2
-
-[Term]
-id: FPLX:BIRC
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:918 ! B3GALNT1
+relationship: inverse_is_a HGNC:28596 ! B3GALNT2
+relationship: inverse_is_a HGNC:20207 ! B3GLCT
+relationship: inverse_is_a HGNC:916 ! B3GALT1
+relationship: inverse_is_a HGNC:917 ! B3GALT2
+relationship: inverse_is_a HGNC:919 ! B3GALT4
+relationship: inverse_is_a HGNC:920 ! B3GALT5
+relationship: inverse_is_a HGNC:17978 ! B3GALT6
+relationship: inverse_is_a HGNC:15629 ! B3GNT2
+relationship: inverse_is_a HGNC:13528 ! B3GNT3
+relationship: inverse_is_a HGNC:15683 ! B3GNT4
+relationship: inverse_is_a HGNC:15684 ! B3GNT5
+relationship: inverse_is_a HGNC:24141 ! B3GNT6
+relationship: inverse_is_a HGNC:18811 ! B3GNT7
+relationship: inverse_is_a HGNC:24139 ! B3GNT8
+relationship: inverse_is_a HGNC:28714 ! B3GNT9
+relationship: inverse_is_a HGNC:24291 ! CHPF
+relationship: inverse_is_a HGNC:29270 ! CHPF2
+relationship: inverse_is_a HGNC:17198 ! CHSY1
+relationship: inverse_is_a HGNC:24293 ! CHSY3
+relationship: inverse_is_a HGNC:24337 ! C1GALT1
+relationship: inverse_is_a HGNC:6560 ! LFNG
+relationship: inverse_is_a HGNC:7038 ! MFNG
+relationship: inverse_is_a HGNC:9974 ! RFNG
+relationship: inverse_is_a HGNC:4117 ! B4GALNT1
+relationship: inverse_is_a HGNC:24136 ! B4GALNT2
+relationship: inverse_is_a HGNC:24137 ! B4GALNT3
+relationship: inverse_is_a HGNC:26315 ! B4GALNT4
+relationship: inverse_is_a HGNC:924 ! B4GALT1
+relationship: inverse_is_a HGNC:925 ! B4GALT2
+relationship: inverse_is_a HGNC:926 ! B4GALT3
+relationship: inverse_is_a HGNC:927 ! B4GALT4
+relationship: inverse_is_a HGNC:928 ! B4GALT5
+relationship: inverse_is_a HGNC:929 ! B4GALT6
+relationship: inverse_is_a HGNC:930 ! B4GALT7
+relationship: inverse_is_a HGNC:24290 ! CSGALNACT1
+relationship: inverse_is_a HGNC:24292 ! CSGALNACT2
+
+[Term]
+id: FPLX:000066
 name: BIRC
 synonym: "BIRs" EXACT []
 xref: BEL:"BIRC Family"
 xref: IP:IPR001370
-is_a: FPLX:root
-inverse_is_a: HGNC:BIRC2
-inverse_is_a: HGNC:BIRC3
-inverse_is_a: HGNC:BIRC5
-inverse_is_a: HGNC:BIRC6
-inverse_is_a: HGNC:BIRC7
-inverse_is_a: HGNC:BIRC8
-inverse_is_a: HGNC:NAIP
-inverse_is_a: HGNC:XIAP
-
-[Term]
-id: FPLX:BMP
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:590 ! BIRC2
+relationship: inverse_is_a HGNC:591 ! BIRC3
+relationship: inverse_is_a HGNC:593 ! BIRC5
+relationship: inverse_is_a HGNC:13516 ! BIRC6
+relationship: inverse_is_a HGNC:13702 ! BIRC7
+relationship: inverse_is_a HGNC:14878 ! BIRC8
+relationship: inverse_is_a HGNC:7634 ! NAIP
+relationship: inverse_is_a HGNC:592 ! XIAP
+
+[Term]
+id: FPLX:000067
 name: BMP
 synonym: "BMP" EXACT []
 xref: BEL:"BMP Family"
 xref: NCIT:C17274
 xref: XFAM:PF02608
-is_a: FPLX:root
-inverse_is_a: HGNC:BMP1
-inverse_is_a: HGNC:BMP2
-inverse_is_a: HGNC:BMP3
-inverse_is_a: HGNC:BMP4
-inverse_is_a: HGNC:BMP5
-inverse_is_a: HGNC:BMP6
-inverse_is_a: HGNC:BMP7
-inverse_is_a: HGNC:BMP8A
-inverse_is_a: HGNC:BMP8B
-inverse_is_a: HGNC:BMP10
-inverse_is_a: HGNC:BMP15
-inverse_is_a: HGNC:GDF1
-inverse_is_a: HGNC:GDF2
-inverse_is_a: HGNC:GDF3
-inverse_is_a: HGNC:GDF5
-inverse_is_a: HGNC:GDF6
-inverse_is_a: HGNC:GDF7
-
-[Term]
-id: FPLX:BMP_receptor
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1067 ! BMP1
+relationship: inverse_is_a HGNC:1069 ! BMP2
+relationship: inverse_is_a HGNC:1070 ! BMP3
+relationship: inverse_is_a HGNC:1071 ! BMP4
+relationship: inverse_is_a HGNC:1072 ! BMP5
+relationship: inverse_is_a HGNC:1073 ! BMP6
+relationship: inverse_is_a HGNC:1074 ! BMP7
+relationship: inverse_is_a HGNC:21650 ! BMP8A
+relationship: inverse_is_a HGNC:1075 ! BMP8B
+relationship: inverse_is_a HGNC:20869 ! BMP10
+relationship: inverse_is_a HGNC:1068 ! BMP15
+relationship: inverse_is_a HGNC:4214 ! GDF1
+relationship: inverse_is_a HGNC:4217 ! GDF2
+relationship: inverse_is_a HGNC:4218 ! GDF3
+relationship: inverse_is_a HGNC:4220 ! GDF5
+relationship: inverse_is_a HGNC:4221 ! GDF6
+relationship: inverse_is_a HGNC:4222 ! GDF7
+
+[Term]
+id: FPLX:000068
 name: BMP-receptor
 xref: SIGNOR:SIGNOR-PF9
-is_a: FPLX:root
-inverse_is_a: FPLX:BMP_receptor_type_I
-inverse_is_a: FPLX:BMP_receptor_type_II
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000069 ! BMP_receptor_type_I
+relationship: inverse_is_a FPLX:000070 ! BMP_receptor_type_II
 
 [Term]
-id: FPLX:BMP_receptor_type_I
+id: FPLX:000069
 name: BMP-receptor-type-I
 synonym: "BMP Receptor Type I" EXACT []
 synonym: "BMP type I receptor" EXACT []
@@ -1148,13 +1167,13 @@ synonym: "bone morphogenetic protein type I receptors" EXACT []
 synonym: "BRI" EXACT []
 xref: BEL:"BMP Receptor Type I Family"
 xref: MEDSCAN:urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor
-is_a: FPLX:BMP_receptor
-inverse_is_a: HGNC:ACVR1
-inverse_is_a: HGNC:BMPR1A
-inverse_is_a: HGNC:BMPR1B
+is_a: FPLX:000068 ! BMP_receptor
+relationship: inverse_is_a HGNC:171 ! ACVR1
+relationship: inverse_is_a HGNC:1076 ! BMPR1A
+relationship: inverse_is_a HGNC:1077 ! BMPR1B
 
 [Term]
-id: FPLX:BMP_receptor_type_II
+id: FPLX:000070
 name: BMP-receptor-type-II
 synonym: "BMP Receptor Type II" EXACT []
 synonym: "BMP type II receptor" EXACT []
@@ -1165,21 +1184,21 @@ synonym: "BRII" EXACT []
 xref: BEL:"BMP Receptor Type II Family"
 xref: RE:R-HSA-201465
 xref: RE:R-HSA-201804
-is_a: FPLX:BMP_receptor
-inverse_is_a: HGNC:ACVR2A
-inverse_is_a: HGNC:ACVR2B
-inverse_is_a: HGNC:BMPR2
+is_a: FPLX:000068 ! BMP_receptor
+relationship: inverse_is_a HGNC:173 ! ACVR2A
+relationship: inverse_is_a HGNC:174 ! ACVR2B
+relationship: inverse_is_a HGNC:1078 ! BMPR2
 
 [Term]
-id: FPLX:BRCA
+id: FPLX:000071
 name: BRCA
 synonym: "BRCA" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:BRCA1
-inverse_is_a: HGNC:BRCA2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1100 ! BRCA1
+relationship: inverse_is_a HGNC:1101 ! BRCA2
 
 [Term]
-id: FPLX:C1
+id: FPLX:000072
 name: C1
 synonym: "c1 complex" EXACT []
 synonym: "C1" EXACT []
@@ -1188,24 +1207,24 @@ xref: BEL:"C1 Complex"
 xref: RE:R-HSA-173584
 xref: RE:R-HSA-173615
 xref: RE:R-HSA-173617
-is_a: FPLX:root
-has_part: HGNC:C1QA
-has_part: HGNC:C1QB
-has_part: HGNC:C1QC
-has_part: HGNC:C1R
-has_part: HGNC:C1S
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1241 ! C1QA
+relationship: has_part HGNC:1242 ! C1QB
+relationship: has_part HGNC:1245 ! C1QC
+relationship: has_part HGNC:1246 ! C1R
+relationship: has_part HGNC:1247 ! C1S
 
 [Term]
-id: FPLX:C1q
+id: FPLX:000073
 name: C1q
 synonym: "C1q" EXACT []
 xref: BEL:"C1q Complex"
-is_a: FPLX:root
-has_part: HGNC:C1QA
-has_part: HGNC:C1QB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1241 ! C1QA
+relationship: has_part HGNC:1242 ! C1QB
 
 [Term]
-id: FPLX:Cadherin
+id: FPLX:000074
 name: Cadherin
 synonym: "cadherin" EXACT []
 xref: BEL:"CDH Family"
@@ -1213,31 +1232,31 @@ xref: MEDSCAN:urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896
 xref: MEDSCAN:urn:agi-protfc:cadherin
 xref: NCIT:C16373
 xref: XFAM:PF00028
-is_a: FPLX:root
-inverse_is_a: HGNC:CDH1
-inverse_is_a: HGNC:CDH10
-inverse_is_a: HGNC:CDH11
-inverse_is_a: HGNC:CDH12
-inverse_is_a: HGNC:CDH13
-inverse_is_a: HGNC:CDH15
-inverse_is_a: HGNC:CDH16
-inverse_is_a: HGNC:CDH17
-inverse_is_a: HGNC:CDH18
-inverse_is_a: HGNC:CDH19
-inverse_is_a: HGNC:CDH2
-inverse_is_a: HGNC:CDH20
-inverse_is_a: HGNC:CDH22
-inverse_is_a: HGNC:CDH24
-inverse_is_a: HGNC:CDH3
-inverse_is_a: HGNC:CDH4
-inverse_is_a: HGNC:CDH5
-inverse_is_a: HGNC:CDH6
-inverse_is_a: HGNC:CDH7
-inverse_is_a: HGNC:CDH8
-inverse_is_a: HGNC:CDH9
-
-[Term]
-id: FPLX:CALM
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1748 ! CDH1
+relationship: inverse_is_a HGNC:1749 ! CDH10
+relationship: inverse_is_a HGNC:1750 ! CDH11
+relationship: inverse_is_a HGNC:1751 ! CDH12
+relationship: inverse_is_a HGNC:1753 ! CDH13
+relationship: inverse_is_a HGNC:1754 ! CDH15
+relationship: inverse_is_a HGNC:1755 ! CDH16
+relationship: inverse_is_a HGNC:1756 ! CDH17
+relationship: inverse_is_a HGNC:1757 ! CDH18
+relationship: inverse_is_a HGNC:1758 ! CDH19
+relationship: inverse_is_a HGNC:1759 ! CDH2
+relationship: inverse_is_a HGNC:1760 ! CDH20
+relationship: inverse_is_a HGNC:13251 ! CDH22
+relationship: inverse_is_a HGNC:14265 ! CDH24
+relationship: inverse_is_a HGNC:1762 ! CDH3
+relationship: inverse_is_a HGNC:1763 ! CDH4
+relationship: inverse_is_a HGNC:1764 ! CDH5
+relationship: inverse_is_a HGNC:1765 ! CDH6
+relationship: inverse_is_a HGNC:1766 ! CDH7
+relationship: inverse_is_a HGNC:1767 ! CDH8
+relationship: inverse_is_a HGNC:1768 ! CDH9
+
+[Term]
+id: FPLX:000075
 name: CALM
 synonym: "Calmodulin" EXACT []
 synonym: "calmodulin" EXACT []
@@ -1247,28 +1266,28 @@ xref: MEDSCAN:urn:agi-aopfc:0000452
 xref: MEDSCAN:urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11
 xref: NCIT:C16375
 xref: NEXTPROT-FAMILY:00440
-is_a: FPLX:root
-inverse_is_a: HGNC:CALM1
-inverse_is_a: HGNC:CALM2
-inverse_is_a: HGNC:CALM3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1442 ! CALM1
+relationship: inverse_is_a HGNC:1445 ! CALM2
+relationship: inverse_is_a HGNC:1449 ! CALM3
 
 [Term]
-id: FPLX:CAMK
+id: FPLX:000076
 name: CAMK
 synonym: "CaMK family" EXACT []
 synonym: "CaMK" EXACT []
 xref: BEL:"CAMK Family"
 xref: ECCODE:2.7.11.17
 xref: NEXTPROT-FAMILY:03072
-is_a: FPLX:root
-inverse_is_a: HGNC:CAMK1
-inverse_is_a: HGNC:CAMK1D
-inverse_is_a: HGNC:CAMK1G
-inverse_is_a: HGNC:CAMK4
-inverse_is_a: FPLX:CAMK2_family
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1459 ! CAMK1
+relationship: inverse_is_a HGNC:19341 ! CAMK1D
+relationship: inverse_is_a HGNC:14585 ! CAMK1G
+relationship: inverse_is_a HGNC:1464 ! CAMK4
+relationship: inverse_is_a FPLX:000078 ! CAMK2_family
 
 [Term]
-id: FPLX:CAMK2_complex
+id: FPLX:000077
 name: CAMK2-complex
 synonym: "Ca(2+)-calmodulin-dependent protein kinase II" EXACT []
 synonym: "Ca(2+)/calmodulin-dependent kinase II" EXACT []
@@ -1282,14 +1301,14 @@ xref: RE:R-HSA-417004
 xref: RE:R-HSA-432792
 xref: RE:R-HSA-444796
 xref: RE:R-HSA-445374
-is_a: FPLX:root
-has_part: HGNC:CAMK2A
-has_part: HGNC:CAMK2B
-has_part: HGNC:CAMK2D
-has_part: HGNC:CAMK2G
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1460 ! CAMK2A
+relationship: has_part HGNC:1461 ! CAMK2B
+relationship: has_part HGNC:1462 ! CAMK2D
+relationship: has_part HGNC:1463 ! CAMK2G
 
 [Term]
-id: FPLX:CAMK2_family
+id: FPLX:000078
 name: CAMK2-family
 synonym: "calmodulindependent kinase II" EXACT []
 synonym: "CAMK2" EXACT []
@@ -1301,14 +1320,14 @@ xref: RE:R-HSA-417004
 xref: RE:R-HSA-432792
 xref: RE:R-HSA-444796
 xref: RE:R-HSA-445374
-is_a: FPLX:CAMK
-inverse_is_a: HGNC:CAMK2A
-inverse_is_a: HGNC:CAMK2B
-inverse_is_a: HGNC:CAMK2D
-inverse_is_a: HGNC:CAMK2G
+is_a: FPLX:000076 ! CAMK
+relationship: inverse_is_a HGNC:1460 ! CAMK2A
+relationship: inverse_is_a HGNC:1461 ! CAMK2B
+relationship: inverse_is_a HGNC:1462 ! CAMK2D
+relationship: inverse_is_a HGNC:1463 ! CAMK2G
 
 [Term]
-id: FPLX:CAPN
+id: FPLX:000079
 name: CAPN
 synonym: "calpain" EXACT []
 xref: BEL:"CAPN Family"
@@ -1317,39 +1336,39 @@ xref: IP:IPR022684
 xref: NCIT:C16377
 xref: RE:R-HSA-8848649
 xref: RE:R-HSA-8848668
-is_a: FPLX:root
-inverse_is_a: HGNC:CAPN1
-inverse_is_a: HGNC:CAPN10
-inverse_is_a: HGNC:CAPN11
-inverse_is_a: HGNC:CAPN12
-inverse_is_a: HGNC:CAPN13
-inverse_is_a: HGNC:CAPN14
-inverse_is_a: HGNC:CAPN2
-inverse_is_a: HGNC:CAPN3
-inverse_is_a: HGNC:CAPN5
-inverse_is_a: HGNC:CAPN6
-inverse_is_a: HGNC:CAPN7
-inverse_is_a: HGNC:CAPN9
-inverse_is_a: HGNC:CAPN15
-inverse_is_a: HGNC:CAPN8
-
-[Term]
-id: FPLX:Carboxylesterase
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1476 ! CAPN1
+relationship: inverse_is_a HGNC:1477 ! CAPN10
+relationship: inverse_is_a HGNC:1478 ! CAPN11
+relationship: inverse_is_a HGNC:13249 ! CAPN12
+relationship: inverse_is_a HGNC:16663 ! CAPN13
+relationship: inverse_is_a HGNC:16664 ! CAPN14
+relationship: inverse_is_a HGNC:1479 ! CAPN2
+relationship: inverse_is_a HGNC:1480 ! CAPN3
+relationship: inverse_is_a HGNC:1482 ! CAPN5
+relationship: inverse_is_a HGNC:1483 ! CAPN6
+relationship: inverse_is_a HGNC:1484 ! CAPN7
+relationship: inverse_is_a HGNC:1486 ! CAPN9
+relationship: inverse_is_a HGNC:11182 ! CAPN15
+relationship: inverse_is_a HGNC:1485 ! CAPN8
+
+[Term]
+id: FPLX:000080
 name: Carboxylesterase
 synonym: "carboxylesterase" EXACT []
 synonym: "carboxylesterases" EXACT []
 xref: BEL:"Carboxylesterase Family"
 xref: ECCODE:3.1.1.1
 xref: NCIT:C112051
-is_a: FPLX:root
-inverse_is_a: HGNC:CES1
-inverse_is_a: HGNC:CES2
-inverse_is_a: HGNC:CES3
-inverse_is_a: HGNC:CES4A
-inverse_is_a: HGNC:CES5A
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1863 ! CES1
+relationship: inverse_is_a HGNC:1864 ! CES2
+relationship: inverse_is_a HGNC:1865 ! CES3
+relationship: inverse_is_a HGNC:26741 ! CES4A
+relationship: inverse_is_a HGNC:26459 ! CES5A
 
 [Term]
-id: FPLX:Caspase
+id: FPLX:000081
 name: Caspase
 synonym: "caspase" EXACT []
 synonym: "caspases" EXACT []
@@ -1360,30 +1379,30 @@ xref: IP:IPR033139
 xref: MESH:D020169
 xref: NCIT:C18153
 xref: XFAM:PF00656
-is_a: FPLX:root
-inverse_is_a: HGNC:CASP1
-inverse_is_a: HGNC:CASP2
-inverse_is_a: HGNC:CASP4
-inverse_is_a: HGNC:CASP5
-inverse_is_a: HGNC:CASP6
-inverse_is_a: HGNC:CASP8
-inverse_is_a: HGNC:CASP9
-inverse_is_a: HGNC:CASP10
-inverse_is_a: HGNC:CASP12
-inverse_is_a: HGNC:CASP14
-inverse_is_a: FPLX:Caspase_3_7
-
-[Term]
-id: FPLX:Caspase_3_7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1499 ! CASP1
+relationship: inverse_is_a HGNC:1503 ! CASP2
+relationship: inverse_is_a HGNC:1505 ! CASP4
+relationship: inverse_is_a HGNC:1506 ! CASP5
+relationship: inverse_is_a HGNC:1507 ! CASP6
+relationship: inverse_is_a HGNC:1509 ! CASP8
+relationship: inverse_is_a HGNC:1511 ! CASP9
+relationship: inverse_is_a HGNC:1500 ! CASP10
+relationship: inverse_is_a HGNC:19004 ! CASP12
+relationship: inverse_is_a HGNC:1502 ! CASP14
+relationship: inverse_is_a FPLX:000082 ! Caspase_3_7
+
+[Term]
+id: FPLX:000082
 name: Caspase-3-7
 synonym: "caspase-3/7" EXACT []
 xref: RE:R-HSA-202877
-is_a: FPLX:Caspase
-inverse_is_a: HGNC:CASP3
-inverse_is_a: HGNC:CASP7
+is_a: FPLX:000081 ! Caspase
+relationship: inverse_is_a HGNC:1504 ! CASP3
+relationship: inverse_is_a HGNC:1508 ! CASP7
 
 [Term]
-id: FPLX:CAV
+id: FPLX:000083
 name: CAV
 synonym: "Caveolin" EXACT []
 synonym: "caveolin" EXACT []
@@ -1393,14 +1412,15 @@ xref: IP:IPR018361
 xref: MEDSCAN:urn:agi-protfc:caveolin
 xref: NEXTPROT-FAMILY:00489
 xref: XFAM:PF01146
-is_a: FPLX:root
-inverse_is_a: HGNC:CAV1
-inverse_is_a: HGNC:CAV2
-inverse_is_a: HGNC:CAV3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1527 ! CAV1
+relationship: inverse_is_a HGNC:1528 ! CAV2
+relationship: inverse_is_a HGNC:1529 ! CAV3
 
 [Term]
-id: FPLX:CBF3
+id: FPLX:000084
 name: CBF3
+def: "SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex" [interpro:IPR016072]
 synonym: "CBF3 complex" EXACT []
 synonym: "CBF3" EXACT []
 synonym: "kinetochore centromere binding factor 3" EXACT []
@@ -1408,11 +1428,11 @@ xref: BEL:"CBF3 Complex"
 xref: GO:0031518
 xref: IP:IPR016072
 xref: IP:IPR016897
-is_a: FPLX:root
-has_part: HGNC:SKP1
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:10899 ! SKP1
 
 [Term]
-id: FPLX:CCT_complex
+id: FPLX:000085
 name: CCT-complex
 synonym: "CCT complex" EXACT []
 synonym: "CCT" EXACT []
@@ -1427,75 +1447,75 @@ xref: IP:IPR002194
 xref: MEDSCAN:urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61
 xref: RE:R-HSA-390455
 xref: RE:R-HSA-390474
-is_a: FPLX:root
-has_part: HGNC:CCT2
-has_part: HGNC:CCT3
-has_part: HGNC:CCT4
-has_part: HGNC:CCT5
-has_part: HGNC:CCT6A
-has_part: HGNC:CCT6B
-has_part: HGNC:CCT7
-has_part: HGNC:CCT8
-has_part: HGNC:TCP1
-
-[Term]
-id: FPLX:CD16
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1615 ! CCT2
+relationship: has_part HGNC:1616 ! CCT3
+relationship: has_part HGNC:1617 ! CCT4
+relationship: has_part HGNC:1618 ! CCT5
+relationship: has_part HGNC:1620 ! CCT6A
+relationship: has_part HGNC:1621 ! CCT6B
+relationship: has_part HGNC:1622 ! CCT7
+relationship: has_part HGNC:1623 ! CCT8
+relationship: has_part HGNC:11655 ! TCP1
+
+[Term]
+id: FPLX:000086
 name: CD16
 synonym: "CD16" EXACT []
 xref: BEL:"CD16 Family"
 xref: NCIT:C17487
-is_a: FPLX:root
-inverse_is_a: HGNC:FCGR3A
-inverse_is_a: HGNC:FCGR3B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3619 ! FCGR3A
+relationship: inverse_is_a HGNC:3620 ! FCGR3B
 
 [Term]
-id: FPLX:CD3
+id: FPLX:000087
 name: CD3
 synonym: "CD3" EXACT []
 xref: BEL:"CD3 Complex"
 xref: MEDSCAN:urn:agi-complex:CD3%20complex
 xref: NCIT:C38897
-is_a: FPLX:root
-has_part: HGNC:CD247
-has_part: HGNC:CD3D
-has_part: HGNC:CD3E
-has_part: HGNC:CD3G
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1677 ! CD247
+relationship: has_part HGNC:1673 ! CD3D
+relationship: has_part HGNC:1674 ! CD3E
+relationship: has_part HGNC:1675 ! CD3G
 
 [Term]
-id: FPLX:CD32
+id: FPLX:000088
 name: CD32
 synonym: "CD32" EXACT []
 xref: BEL:"CD32 Family"
 xref: NCIT:C18308
-is_a: FPLX:root
-inverse_is_a: HGNC:FCGR2A
-inverse_is_a: HGNC:FCGR2B
-inverse_is_a: HGNC:FCGR2C
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3616 ! FCGR2A
+relationship: inverse_is_a HGNC:3618 ! FCGR2B
+relationship: inverse_is_a HGNC:15626 ! FCGR2C
 
 [Term]
-id: FPLX:CD64
+id: FPLX:000089
 name: CD64
 synonym: "CD64" EXACT []
 xref: BEL:"CD64 Family"
 xref: RE:R-HSA-1031694
 xref: RE:R-HSA-1236898
 xref: RE:R-HSA-1236905
-is_a: FPLX:root
-inverse_is_a: HGNC:FCGR1A
-inverse_is_a: HGNC:FCGR1B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3613 ! FCGR1A
+relationship: inverse_is_a HGNC:3614 ! FCGR1B
 
 [Term]
-id: FPLX:CD8
+id: FPLX:000090
 name: CD8
 synonym: "CD8" EXACT []
 xref: MEDSCAN:urn:agi-complex:CD8
 xref: RE:R-HSA-198899
-is_a: FPLX:root
-inverse_is_a: HGNC:CD8A
-inverse_is_a: HGNC:CD8B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1706 ! CD8A
+relationship: inverse_is_a HGNC:1707 ! CD8B
 
 [Term]
-id: FPLX:CDC25
+id: FPLX:000091
 name: CDC25
 synonym: "CDC25 family" EXACT []
 synonym: "Cdc25 phosphatases" EXACT []
@@ -1506,13 +1526,13 @@ xref: IP:IPR000751
 xref: MEDSCAN:urn:agi-aopfc:0000551
 xref: RE:R-HSA-170108
 xref: RE:R-HSA-69261
-is_a: FPLX:root
-inverse_is_a: HGNC:CDC25A
-inverse_is_a: HGNC:CDC25B
-inverse_is_a: HGNC:CDC25C
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1725 ! CDC25A
+relationship: inverse_is_a HGNC:1726 ! CDC25B
+relationship: inverse_is_a HGNC:1727 ! CDC25C
 
 [Term]
-id: FPLX:CDK
+id: FPLX:000092
 name: CDK
 synonym: "CDK" EXACT []
 synonym: "Cdk" EXACT []
@@ -1521,45 +1541,45 @@ xref: ECCODE:2.7.11.22
 xref: MEDSCAN:urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee
 xref: MESH:D018844
 xref: NCIT:C17767
-is_a: FPLX:root
-inverse_is_a: HGNC:CDKL1
-inverse_is_a: HGNC:CDKL2
-inverse_is_a: HGNC:CDKL3
-inverse_is_a: HGNC:CDKL4
-inverse_is_a: HGNC:CDKL5
-inverse_is_a: FPLX:CDK1_2
-inverse_is_a: HGNC:CDK3
-inverse_is_a: HGNC:CDK4
-inverse_is_a: HGNC:CDK5
-inverse_is_a: HGNC:CDK6
-inverse_is_a: HGNC:CDK7
-inverse_is_a: HGNC:CDK8
-inverse_is_a: HGNC:CDK9
-inverse_is_a: HGNC:CDK10
-inverse_is_a: HGNC:CDK11A
-inverse_is_a: HGNC:CDK11B
-inverse_is_a: HGNC:CDK12
-inverse_is_a: HGNC:CDK13
-inverse_is_a: HGNC:CDK14
-inverse_is_a: HGNC:CDK15
-inverse_is_a: HGNC:CDK16
-inverse_is_a: HGNC:CDK17
-inverse_is_a: HGNC:CDK18
-inverse_is_a: HGNC:CDK19
-inverse_is_a: HGNC:CDK20
-
-[Term]
-id: FPLX:CDK1_2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1781 ! CDKL1
+relationship: inverse_is_a HGNC:1782 ! CDKL2
+relationship: inverse_is_a HGNC:15483 ! CDKL3
+relationship: inverse_is_a HGNC:19287 ! CDKL4
+relationship: inverse_is_a HGNC:11411 ! CDKL5
+relationship: inverse_is_a FPLX:000093 ! CDK1_2
+relationship: inverse_is_a HGNC:1772 ! CDK3
+relationship: inverse_is_a HGNC:1773 ! CDK4
+relationship: inverse_is_a HGNC:1774 ! CDK5
+relationship: inverse_is_a HGNC:1777 ! CDK6
+relationship: inverse_is_a HGNC:1778 ! CDK7
+relationship: inverse_is_a HGNC:1779 ! CDK8
+relationship: inverse_is_a HGNC:1780 ! CDK9
+relationship: inverse_is_a HGNC:1770 ! CDK10
+relationship: inverse_is_a HGNC:1730 ! CDK11A
+relationship: inverse_is_a HGNC:1729 ! CDK11B
+relationship: inverse_is_a HGNC:24224 ! CDK12
+relationship: inverse_is_a HGNC:1733 ! CDK13
+relationship: inverse_is_a HGNC:8883 ! CDK14
+relationship: inverse_is_a HGNC:14434 ! CDK15
+relationship: inverse_is_a HGNC:8749 ! CDK16
+relationship: inverse_is_a HGNC:8750 ! CDK17
+relationship: inverse_is_a HGNC:8751 ! CDK18
+relationship: inverse_is_a HGNC:19338 ! CDK19
+relationship: inverse_is_a HGNC:21420 ! CDK20
+
+[Term]
+id: FPLX:000093
 name: CDK1-2
 synonym: "CDK1/2" EXACT []
 synonym: "cdk1/2" EXACT []
 synonym: "Cdk1/2" EXACT []
-is_a: FPLX:CDK
-inverse_is_a: HGNC:CDK1
-inverse_is_a: HGNC:CDK2
+is_a: FPLX:000092 ! CDK
+relationship: inverse_is_a HGNC:1722 ! CDK1
+relationship: inverse_is_a HGNC:1771 ! CDK2
 
 [Term]
-id: FPLX:CDKN
+id: FPLX:000094
 name: CDKN
 synonym: "CDKN" EXACT []
 synonym: "CKI" EXACT []
@@ -1568,100 +1588,100 @@ synonym: "cyclin-dependent kinase inhibitor" EXACT []
 synonym: "cyclin-dependent protein kinase inhibitors" EXACT []
 xref: NCIT:C18492
 xref: XFAM:PF02234
-is_a: FPLX:root
-inverse_is_a: FPLX:CDKN1
-inverse_is_a: FPLX:CDKN2
-inverse_is_a: HGNC:CDKN3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000095 ! CDKN1
+relationship: inverse_is_a FPLX:000096 ! CDKN2
+relationship: inverse_is_a HGNC:1791 ! CDKN3
 
 [Term]
-id: FPLX:CDKN1
+id: FPLX:000095
 name: CDKN1
 synonym: "CDKN1" EXACT []
 xref: IP:IPR003175
 xref: RE:R-HSA-8941923
 xref: RE:R-HSA-8942604
 xref: RE:R-HSA-8948131
-is_a: FPLX:CDKN
-inverse_is_a: HGNC:CDKN1A
-inverse_is_a: HGNC:CDKN1B
-inverse_is_a: HGNC:CDKN1C
+is_a: FPLX:000094 ! CDKN
+relationship: inverse_is_a HGNC:1784 ! CDKN1A
+relationship: inverse_is_a HGNC:1785 ! CDKN1B
+relationship: inverse_is_a HGNC:1786 ! CDKN1C
 
 [Term]
-id: FPLX:CDKN2
+id: FPLX:000096
 name: CDKN2
 synonym: "CDKN2" EXACT []
-is_a: FPLX:CDKN
-inverse_is_a: HGNC:CDKN2A
-inverse_is_a: HGNC:CDKN2B
-inverse_is_a: HGNC:CDKN2C
-inverse_is_a: HGNC:CDKN2D
+is_a: FPLX:000094 ! CDKN
+relationship: inverse_is_a HGNC:1787 ! CDKN2A
+relationship: inverse_is_a HGNC:1788 ! CDKN2B
+relationship: inverse_is_a HGNC:1789 ! CDKN2C
+relationship: inverse_is_a HGNC:1790 ! CDKN2D
 
 [Term]
-id: FPLX:CEBP
+id: FPLX:000097
 name: CEBP
 synonym: "C/EBP" EXACT []
 synonym: "CCAAT/enhancer binding protein" EXACT []
 xref: BEL:"CEBP Family"
 xref: NEXTPROT-FAMILY:00406
-is_a: FPLX:root
-inverse_is_a: HGNC:CEBPA
-inverse_is_a: HGNC:CEBPB
-inverse_is_a: HGNC:CEBPD
-inverse_is_a: HGNC:CEBPG
-inverse_is_a: HGNC:CEBPE
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1833 ! CEBPA
+relationship: inverse_is_a HGNC:1834 ! CEBPB
+relationship: inverse_is_a HGNC:1835 ! CEBPD
+relationship: inverse_is_a HGNC:1837 ! CEBPG
+relationship: inverse_is_a HGNC:1836 ! CEBPE
 
 [Term]
-id: FPLX:CHEK
+id: FPLX:000098
 name: CHEK
 synonym: "checkpoint kinase" EXACT []
 synonym: "Chk1/2" EXACT []
 xref: MEDSCAN:urn:agi-protfc:checkpoint%20kinase
-is_a: FPLX:root
-inverse_is_a: HGNC:CHEK1
-inverse_is_a: HGNC:CHEK2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1925 ! CHEK1
+relationship: inverse_is_a HGNC:16627 ! CHEK2
 
 [Term]
-id: FPLX:Chemokine
+id: FPLX:000099
 name: Chemokine
 synonym: "chemokine" EXACT []
 synonym: "chemokines" EXACT []
 xref: MEDSCAN:urn:agi-aopfc:0000391
 xref: NCIT:C20466
-is_a: FPLX:root
-inverse_is_a: FPLX:CXCL_ELR_negative
-inverse_is_a: FPLX:CXCL_ELR_positive
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000128 ! CXCL_ELR_negative
+relationship: inverse_is_a FPLX:000129 ! CXCL_ELR_positive
 
 [Term]
-id: FPLX:Chemokine_receptor
+id: FPLX:000100
 name: Chemokine-receptor
 synonym: "chemoattractant receptor" EXACT []
 xref: BEL:"Chemokine Receptor Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:ACKR2
-inverse_is_a: HGNC:CCR1
-inverse_is_a: HGNC:CCR10
-inverse_is_a: HGNC:CCR2
-inverse_is_a: HGNC:CCR3
-inverse_is_a: HGNC:CCR4
-inverse_is_a: HGNC:CCR5
-inverse_is_a: HGNC:CCR6
-inverse_is_a: HGNC:CCR7
-inverse_is_a: HGNC:CCR8
-inverse_is_a: HGNC:CCR9
-inverse_is_a: HGNC:ACKR4
-inverse_is_a: HGNC:CCRL2
-inverse_is_a: HGNC:CX3CR1
-inverse_is_a: HGNC:CXCR1
-inverse_is_a: HGNC:CXCR2
-inverse_is_a: HGNC:CXCR3
-inverse_is_a: HGNC:CXCR4
-inverse_is_a: HGNC:CXCR5
-inverse_is_a: HGNC:CXCR6
-inverse_is_a: HGNC:ACKR3
-inverse_is_a: HGNC:XCR1
-
-[Term]
-id: FPLX:Cholinesterase
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1565 ! ACKR2
+relationship: inverse_is_a HGNC:1602 ! CCR1
+relationship: inverse_is_a HGNC:4474 ! CCR10
+relationship: inverse_is_a HGNC:1603 ! CCR2
+relationship: inverse_is_a HGNC:1604 ! CCR3
+relationship: inverse_is_a HGNC:1605 ! CCR4
+relationship: inverse_is_a HGNC:1606 ! CCR5
+relationship: inverse_is_a HGNC:1607 ! CCR6
+relationship: inverse_is_a HGNC:1608 ! CCR7
+relationship: inverse_is_a HGNC:1609 ! CCR8
+relationship: inverse_is_a HGNC:1610 ! CCR9
+relationship: inverse_is_a HGNC:1611 ! ACKR4
+relationship: inverse_is_a HGNC:1612 ! CCRL2
+relationship: inverse_is_a HGNC:2558 ! CX3CR1
+relationship: inverse_is_a HGNC:6026 ! CXCR1
+relationship: inverse_is_a HGNC:6027 ! CXCR2
+relationship: inverse_is_a HGNC:4540 ! CXCR3
+relationship: inverse_is_a HGNC:2561 ! CXCR4
+relationship: inverse_is_a HGNC:1060 ! CXCR5
+relationship: inverse_is_a HGNC:16647 ! CXCR6
+relationship: inverse_is_a HGNC:23692 ! ACKR3
+relationship: inverse_is_a HGNC:1625 ! XCR1
+
+[Term]
+id: FPLX:000101
 name: Cholinesterase
 synonym: "choline esterase" EXACT []
 synonym: "cholinesterase" EXACT []
@@ -1670,44 +1690,44 @@ xref: IP:IPR000997
 xref: IP:IPR014788
 xref: RE:R-HSA-2990868
 xref: RE:R-HSA-3640837
-is_a: FPLX:root
-inverse_is_a: HGNC:ACHE
-inverse_is_a: HGNC:BCHE
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:108 ! ACHE
+relationship: inverse_is_a HGNC:983 ! BCHE
 
 [Term]
-id: FPLX:CHRM
+id: FPLX:000102
 name: CHRM
 synonym: "acetylcholine receptor" EXACT []
 xref: BEL:"CHRM Family"
 xref: IP:IPR000995
-is_a: FPLX:root
-inverse_is_a: HGNC:CHRM1
-inverse_is_a: HGNC:CHRM2
-inverse_is_a: HGNC:CHRM3
-inverse_is_a: HGNC:CHRM4
-inverse_is_a: HGNC:CHRM5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1950 ! CHRM1
+relationship: inverse_is_a HGNC:1951 ! CHRM2
+relationship: inverse_is_a HGNC:1952 ! CHRM3
+relationship: inverse_is_a HGNC:1953 ! CHRM4
+relationship: inverse_is_a HGNC:1954 ! CHRM5
 
 [Term]
-id: FPLX:CHRN
+id: FPLX:000103
 name: CHRN
 synonym: "nAChR" EXACT []
 synonym: "nicotine class acetylcholine receptors" EXACT []
 synonym: "nicotinic acetylcholine receptor" EXACT []
 xref: BEL:"CHRN Complex"
 xref: GO:0016904
-is_a: FPLX:root
-has_part: HGNC:CHRNA2
-has_part: HGNC:CHRNA3
-has_part: HGNC:CHRNA4
-has_part: HGNC:CHRNA5
-has_part: HGNC:CHRNA6
-has_part: HGNC:CHRNA7
-has_part: HGNC:CHRNB2
-has_part: HGNC:CHRNB3
-has_part: HGNC:CHRNB4
-
-[Term]
-id: FPLX:CK2
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1956 ! CHRNA2
+relationship: has_part HGNC:1957 ! CHRNA3
+relationship: has_part HGNC:1958 ! CHRNA4
+relationship: has_part HGNC:1959 ! CHRNA5
+relationship: has_part HGNC:15963 ! CHRNA6
+relationship: has_part HGNC:1960 ! CHRNA7
+relationship: has_part HGNC:1962 ! CHRNB2
+relationship: has_part HGNC:1963 ! CHRNB3
+relationship: has_part HGNC:1964 ! CHRNB4
+
+[Term]
+id: FPLX:000104
 name: CK2
 synonym: "casein kinase 2" EXACT []
 synonym: "casein kinase II complex" EXACT []
@@ -1719,13 +1739,13 @@ xref: NCIT:C107559
 xref: NEXTPROT-FAMILY:03101
 xref: RE:R-HSA-201711
 xref: RE:R-HSA-6805066
-is_a: FPLX:root
-has_part: HGNC:CSNK2A1
-has_part: HGNC:CSNK2A2
-has_part: HGNC:CSNK2B
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2457 ! CSNK2A1
+relationship: has_part HGNC:2459 ! CSNK2A2
+relationship: has_part HGNC:2460 ! CSNK2B
 
 [Term]
-id: FPLX:Clathrin
+id: FPLX:000105
 name: Clathrin
 synonym: "clathrin coat" EXACT []
 synonym: "clathrin" EXACT []
@@ -1734,33 +1754,33 @@ xref: GO:0016190
 xref: RE:R-HSA-5138439
 xref: RE:R-HSA-5138447
 xref: RE:R-HSA-5333713
-is_a: FPLX:root
-has_part: HGNC:CLTA
-has_part: HGNC:CLTB
-has_part: HGNC:CLTC
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2090 ! CLTA
+relationship: has_part HGNC:2091 ! CLTB
+relationship: has_part HGNC:2092 ! CLTC
 
 [Term]
-id: FPLX:CNKSR
+id: FPLX:000106
 name: CNKSR
 synonym: "CNKSR" EXACT []
 synonym: "connector enhancer of kinase suppressor of ras" EXACT []
 xref: NEXTPROT-FAMILY:00653
-is_a: FPLX:root
-inverse_is_a: HGNC:CNKSR1
-inverse_is_a: HGNC:CNKSR2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:19700 ! CNKSR1
+relationship: inverse_is_a HGNC:19701 ! CNKSR2
 
 [Term]
-id: FPLX:Cofilin
+id: FPLX:000107
 name: Cofilin
 synonym: "cofilin" EXACT []
 xref: IP:IPR017904
-is_a: FPLX:root
-inverse_is_a: HGNC:CFL1
-inverse_is_a: HGNC:CFL2
-inverse_is_a: HGNC:DSTN
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1874 ! CFL1
+relationship: inverse_is_a HGNC:1875 ! CFL2
+relationship: inverse_is_a HGNC:15750 ! DSTN
 
 [Term]
-id: FPLX:Cohesin
+id: FPLX:000108
 name: Cohesin
 synonym: "cohesin complex" EXACT []
 synonym: "cohesin" EXACT []
@@ -1768,12 +1788,12 @@ xref: BEL:"Cohesin Complex"
 xref: GO:0008278
 xref: GO:0008279
 xref: XFAM:PF00963
-is_a: FPLX:root
-has_part: HGNC:RAD21
-has_part: HGNC:SMC3
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9811 ! RAD21
+relationship: has_part HGNC:2468 ! SMC3
 
 [Term]
-id: FPLX:COL1
+id: FPLX:000109
 name: COL1
 synonym: "collagen type I" EXACT []
 synonym: "Type I collagen" EXACT []
@@ -1794,12 +1814,12 @@ xref: RE:R-HSA-2396456
 xref: RE:R-HSA-2396478
 xref: RE:R-HSA-2399520
 xref: RE:R-HSA-2428941
-is_a: FPLX:root
-inverse_is_a: HGNC:COL1A1
-inverse_is_a: HGNC:COL1A2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2197 ! COL1A1
+relationship: inverse_is_a HGNC:2198 ! COL1A2
 
 [Term]
-id: FPLX:COL4
+id: FPLX:000110
 name: COL4
 synonym: "Col4" EXACT []
 synonym: "ColIV" EXACT []
@@ -1811,16 +1831,16 @@ xref: GO:0005587
 xref: IP:IPR001442
 xref: NCIT:C16448
 xref: RE:R-HSA-2127389
-is_a: FPLX:root
-inverse_is_a: HGNC:COL4A1
-inverse_is_a: HGNC:COL4A2
-inverse_is_a: HGNC:COL4A3
-inverse_is_a: HGNC:COL4A4
-inverse_is_a: HGNC:COL4A5
-inverse_is_a: HGNC:COL4A6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2202 ! COL4A1
+relationship: inverse_is_a HGNC:2203 ! COL4A2
+relationship: inverse_is_a HGNC:2204 ! COL4A3
+relationship: inverse_is_a HGNC:2206 ! COL4A4
+relationship: inverse_is_a HGNC:2207 ! COL4A5
+relationship: inverse_is_a HGNC:2208 ! COL4A6
 
 [Term]
-id: FPLX:COL5
+id: FPLX:000111
 name: COL5
 synonym: "collagen type V" EXACT []
 synonym: "type V collagen" EXACT []
@@ -1829,59 +1849,59 @@ xref: BEL:"COL5 Family"
 xref: GO:0005588
 xref: RE:R-HSA-2127310
 xref: RE:R-HSA-2127422
-is_a: FPLX:root
-inverse_is_a: HGNC:COL5A1
-inverse_is_a: HGNC:COL5A2
-inverse_is_a: HGNC:COL5A3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2209 ! COL5A1
+relationship: inverse_is_a HGNC:2210 ! COL5A2
+relationship: inverse_is_a HGNC:14864 ! COL5A3
 
 [Term]
-id: FPLX:COLGALT
+id: FPLX:000112
 name: COLGALT
 synonym: "COLGALT" EXACT []
 synonym: "Collagen beta(1-O)galactosyltransferase" EXACT []
 synonym: "Collagen beta(1-O)galactosyltransferases" EXACT []
 synonym: "collagen beta(1-O)galactosyltransferase" EXACT []
 synonym: "collagen beta(1-O)galactosyltransferases" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:COLGALT1
-inverse_is_a: HGNC:COLGALT2
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:26182 ! COLGALT1
+relationship: inverse_is_a HGNC:16790 ! COLGALT2
 
 [Term]
-id: FPLX:COX
+id: FPLX:000113
 name: COX
 synonym: "Complex IV" EXACT []
 synonym: "cytochrome c oxidase" EXACT []
 xref: BEL:"Cytochrome C Oxidase Complex Muscle"
 xref: BEL:"Cytochrome C Oxidase Complex Non Muscle"
 xref: ECCODE:1.9.3.1
-is_a: FPLX:root
-has_part: HGNC:COX5A
-has_part: HGNC:COX5B
-has_part: FPLX:COX4
-has_part: FPLX:COX6A
-has_part: FPLX:COX6B
-has_part: FPLX:COX7A
-has_part: FPLX:COX7B
-has_part: FPLX:COX8
-has_part: HGNC:COX10
-has_part: HGNC:COX11
-has_part: HGNC:COX15
-has_part: HGNC:COX17
-
-[Term]
-id: FPLX:COX4
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2267 ! COX5A
+relationship: has_part HGNC:2269 ! COX5B
+relationship: has_part FPLX:000114 ! COX4
+relationship: has_part FPLX:000115 ! COX6A
+relationship: has_part FPLX:000116 ! COX6B
+relationship: has_part FPLX:000117 ! COX7A
+relationship: has_part FPLX:000118 ! COX7B
+relationship: has_part FPLX:000119 ! COX8
+relationship: has_part HGNC:2260 ! COX10
+relationship: has_part HGNC:2261 ! COX11
+relationship: has_part HGNC:2263 ! COX15
+relationship: has_part HGNC:2264 ! COX17
+
+[Term]
+id: FPLX:000114
 name: COX4
 synonym: "Cox4" EXACT []
 xref: BEL:"COX4 Family"
 xref: IP:IPR004203
 xref: IP:IPR013288
 xref: XFAM:PF02936
-part_of: FPLX:COX
-inverse_is_a: HGNC:COX4I1
-inverse_is_a: HGNC:COX4I2
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2265 ! COX4I1
+relationship: inverse_is_a HGNC:16232 ! COX4I2
 
 [Term]
-id: FPLX:COX6A
+id: FPLX:000115
 name: COX6A
 synonym: "COX6A" EXACT []
 synonym: "Cox6a" EXACT []
@@ -1890,77 +1910,77 @@ xref: BEL:"COX6A Family"
 xref: IP:IPR001349
 xref: IP:IPR018507
 xref: XFAM:PF02046
-part_of: FPLX:COX
-inverse_is_a: HGNC:COX6A1
-inverse_is_a: HGNC:COX6A2
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2277 ! COX6A1
+relationship: inverse_is_a HGNC:2279 ! COX6A2
 
 [Term]
-id: FPLX:COX6B
+id: FPLX:000116
 name: COX6B
 synonym: "Cox6b" EXACT []
 xref: BEL:"COX6B Family"
 xref: XFAM:PF02297
-part_of: FPLX:COX
-inverse_is_a: HGNC:COX6B1
-inverse_is_a: HGNC:COX6B2
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2280 ! COX6B1
+relationship: inverse_is_a HGNC:24380 ! COX6B2
 
 [Term]
-id: FPLX:COX7A
+id: FPLX:000117
 name: COX7A
 synonym: "COX7A" EXACT []
 synonym: "Cox7a" EXACT []
 xref: BEL:"COX7A Family"
 xref: XFAM:PF02238
-part_of: FPLX:COX
-inverse_is_a: HGNC:COX7A1
-inverse_is_a: HGNC:COX7A2
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2287 ! COX7A1
+relationship: inverse_is_a HGNC:2288 ! COX7A2
 
 [Term]
-id: FPLX:COX7B
+id: FPLX:000118
 name: COX7B
 synonym: "Cox7b" EXACT []
 xref: BEL:"COX7B Family"
 xref: IP:IPR008433
 xref: IP:IPR023272
 xref: XFAM:PF05392
-part_of: FPLX:COX
-inverse_is_a: HGNC:COX7B
-inverse_is_a: HGNC:COX7B2
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2291 ! COX7B
+relationship: inverse_is_a HGNC:24381 ! COX7B2
 
 [Term]
-id: FPLX:COX8
+id: FPLX:000119
 name: COX8
 synonym: "Cox8" EXACT []
 synonym: "cytochrome c oxidase subunit VIII" EXACT []
 xref: BEL:"COX8 Family"
 xref: IP:IPR003205
 xref: XFAM:PF02285
-part_of: FPLX:COX
-inverse_is_a: HGNC:COX8A
-inverse_is_a: HGNC:COX8C
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2294 ! COX8A
+relationship: inverse_is_a HGNC:24382 ! COX8C
 
 [Term]
-id: FPLX:CREB
+id: FPLX:000120
 name: CREB
 synonym: "CREB family" EXACT []
 synonym: "CREB" EXACT []
 xref: BEL:"CREB Family"
 xref: MEDSCAN:urn:agi-aopfc:0000094
 xref: NCIT:C17286
-is_a: FPLX:root
-inverse_is_a: HGNC:CREB1
-inverse_is_a: HGNC:CREB3
-inverse_is_a: HGNC:CREB5
-inverse_is_a: HGNC:CREB3L1
-inverse_is_a: HGNC:CREB3L2
-inverse_is_a: HGNC:CREB3L3
-inverse_is_a: HGNC:CREB3L4
-inverse_is_a: HGNC:CREM
-inverse_is_a: HGNC:ATF1
-inverse_is_a: HGNC:ATF2
-
-[Term]
-id: FPLX:CRISP
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2345 ! CREB1
+relationship: inverse_is_a HGNC:2347 ! CREB3
+relationship: inverse_is_a HGNC:16844 ! CREB5
+relationship: inverse_is_a HGNC:18856 ! CREB3L1
+relationship: inverse_is_a HGNC:23720 ! CREB3L2
+relationship: inverse_is_a HGNC:18855 ! CREB3L3
+relationship: inverse_is_a HGNC:18854 ! CREB3L4
+relationship: inverse_is_a HGNC:2352 ! CREM
+relationship: inverse_is_a HGNC:783 ! ATF1
+relationship: inverse_is_a HGNC:784 ! ATF2
+
+[Term]
+id: FPLX:000121
 name: CRISP
 synonym: "CRISP" EXACT []
 synonym: "CRISPs" EXACT []
@@ -1970,13 +1990,13 @@ xref: BEL:"CRISP Family"
 xref: IP:IPR013871
 xref: IP:IPR034117
 xref: XFAM:PF08562
-is_a: FPLX:root
-inverse_is_a: HGNC:CRISP1
-inverse_is_a: HGNC:CRISP2
-inverse_is_a: HGNC:CRISP3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:304 ! CRISP1
+relationship: inverse_is_a HGNC:12024 ! CRISP2
+relationship: inverse_is_a HGNC:16904 ! CRISP3
 
 [Term]
-id: FPLX:CRSP
+id: FPLX:000122
 name: CRSP
 synonym: "CRSP complex" EXACT []
 synonym: "CRSP" EXACT []
@@ -1984,26 +2004,26 @@ synonym: "CRSP/Med complex" EXACT []
 synonym: "transcriptional cofactor complex CRSP" EXACT []
 xref: BEL:"CRSP Complex"
 xref: NCIT:C28687
-is_a: FPLX:root
-has_part: HGNC:MED1
-has_part: HGNC:MED14
-has_part: HGNC:MED17
-has_part: HGNC:MED23
-has_part: HGNC:MED26
-has_part: HGNC:MED27
-has_part: HGNC:MED7
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9234 ! MED1
+relationship: has_part HGNC:2370 ! MED14
+relationship: has_part HGNC:2375 ! MED17
+relationship: has_part HGNC:2372 ! MED23
+relationship: has_part HGNC:2376 ! MED26
+relationship: has_part HGNC:2377 ! MED27
+relationship: has_part HGNC:2378 ! MED7
 
 [Term]
-id: FPLX:CRTC
+id: FPLX:000123
 name: CRTC
 synonym: "CRTC" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:CRTC1
-inverse_is_a: HGNC:CRTC2
-inverse_is_a: HGNC:CRTC3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:16062 ! CRTC1
+relationship: inverse_is_a HGNC:27301 ! CRTC2
+relationship: inverse_is_a HGNC:26148 ! CRTC3
 
 [Term]
-id: FPLX:CSNK1
+id: FPLX:000124
 name: CSNK1
 synonym: "Casein kinase 1" EXACT []
 synonym: "casein kinase 1" EXACT []
@@ -2012,17 +2032,17 @@ synonym: "CSNK1" EXACT []
 xref: BEL:"CSNK1 Family"
 xref: MEDSCAN:urn:agi-protfc:casein%20kinase%20I
 xref: NEXTPROT-FAMILY:03083
-is_a: FPLX:root
-inverse_is_a: HGNC:CSNK1A1
-inverse_is_a: HGNC:CSNK1A1L
-inverse_is_a: HGNC:CSNK1D
-inverse_is_a: HGNC:CSNK1E
-inverse_is_a: HGNC:CSNK1G1
-inverse_is_a: HGNC:CSNK1G2
-inverse_is_a: HGNC:CSNK1G3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2451 ! CSNK1A1
+relationship: inverse_is_a HGNC:20289 ! CSNK1A1L
+relationship: inverse_is_a HGNC:2452 ! CSNK1D
+relationship: inverse_is_a HGNC:2453 ! CSNK1E
+relationship: inverse_is_a HGNC:2454 ! CSNK1G1
+relationship: inverse_is_a HGNC:2455 ! CSNK1G2
+relationship: inverse_is_a HGNC:2456 ! CSNK1G3
 
 [Term]
-id: FPLX:CSNK2
+id: FPLX:000125
 name: CSNK2
 synonym: "CSNK2" EXACT []
 xref: BEL:"CSNK2 Family"
@@ -2030,12 +2050,12 @@ xref: RE:R-HSA-5083623
 xref: RE:R-HSA-5083624
 xref: RE:R-HSA-6805064
 xref: RE:R-HSA-6805073
-is_a: FPLX:root
-inverse_is_a: HGNC:CSNK2A1
-inverse_is_a: HGNC:CSNK2A2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2457 ! CSNK2A1
+relationship: inverse_is_a HGNC:2459 ! CSNK2A2
 
 [Term]
-id: FPLX:CTNNA
+id: FPLX:000126
 name: CTNNA
 synonym: "a-cathenin" EXACT []
 synonym: "alpha catenin" EXACT []
@@ -2045,13 +2065,13 @@ synonym: "catenin α" EXACT []
 synonym: "α catenin" EXACT []
 synonym: "α-catenin" EXACT []
 xref: BEL:"CTNNA Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:CTNNA1
-inverse_is_a: HGNC:CTNNA2
-inverse_is_a: HGNC:CTNNA3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2509 ! CTNNA1
+relationship: inverse_is_a HGNC:2510 ! CTNNA2
+relationship: inverse_is_a HGNC:2511 ! CTNNA3
 
 [Term]
-id: FPLX:CUL
+id: FPLX:000127
 name: CUL
 synonym: "cullin proteins" EXACT []
 synonym: "cullin" EXACT []
@@ -2061,50 +2081,50 @@ xref: MEDSCAN:urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9
 xref: MEDSCAN:urn:agi-protfc:cullin
 xref: NEXTPROT-FAMILY:00787
 xref: XFAM:PF00888
-is_a: FPLX:root
-inverse_is_a: HGNC:CUL1
-inverse_is_a: HGNC:CUL2
-inverse_is_a: HGNC:CUL3
-inverse_is_a: HGNC:CUL4A
-inverse_is_a: HGNC:CUL4B
-inverse_is_a: HGNC:CUL5
-inverse_is_a: HGNC:CUL7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2551 ! CUL1
+relationship: inverse_is_a HGNC:2552 ! CUL2
+relationship: inverse_is_a HGNC:2553 ! CUL3
+relationship: inverse_is_a HGNC:2554 ! CUL4A
+relationship: inverse_is_a HGNC:2555 ! CUL4B
+relationship: inverse_is_a HGNC:2556 ! CUL5
+relationship: inverse_is_a HGNC:21024 ! CUL7
 
 [Term]
-id: FPLX:CXCL_ELR_negative
+id: FPLX:000128
 name: CXCL-ELR-negative
 synonym: "ELR (-) CXC chemokines" EXACT []
 synonym: "ELR-negative CXC chemokine" EXACT []
 synonym: "ELR-negative CXC family" EXACT []
 synonym: "non-ELR-CXC chemokines" EXACT []
 xref: BEL:"CXCL ELR-Negative Family"
-is_a: FPLX:Chemokine
-inverse_is_a: HGNC:CXCL10
-inverse_is_a: HGNC:CXCL11
-inverse_is_a: HGNC:CXCL12
-inverse_is_a: HGNC:CXCL13
-inverse_is_a: HGNC:CXCL14
-inverse_is_a: HGNC:CXCL9
-inverse_is_a: HGNC:PF4
+is_a: FPLX:000099 ! Chemokine
+relationship: inverse_is_a HGNC:10637 ! CXCL10
+relationship: inverse_is_a HGNC:10638 ! CXCL11
+relationship: inverse_is_a HGNC:10672 ! CXCL12
+relationship: inverse_is_a HGNC:10639 ! CXCL13
+relationship: inverse_is_a HGNC:10640 ! CXCL14
+relationship: inverse_is_a HGNC:7098 ! CXCL9
+relationship: inverse_is_a HGNC:8861 ! PF4
 
 [Term]
-id: FPLX:CXCL_ELR_positive
+id: FPLX:000129
 name: CXCL-ELR-positive
 synonym: "ELR (+) CXC chemokines" EXACT []
 synonym: "ELR-positive CXC chemokine" EXACT []
 synonym: "ELR-positive CXC family" EXACT []
 xref: BEL:"CXCL ELR-Positive Family"
-is_a: FPLX:Chemokine
-inverse_is_a: HGNC:CXCL1
-inverse_is_a: HGNC:CXCL2
-inverse_is_a: HGNC:CXCL3
-inverse_is_a: HGNC:CXCL5
-inverse_is_a: HGNC:CXCL6
-inverse_is_a: HGNC:CXCL8
-inverse_is_a: HGNC:PPBP
+is_a: FPLX:000099 ! Chemokine
+relationship: inverse_is_a HGNC:4602 ! CXCL1
+relationship: inverse_is_a HGNC:4603 ! CXCL2
+relationship: inverse_is_a HGNC:4604 ! CXCL3
+relationship: inverse_is_a HGNC:10642 ! CXCL5
+relationship: inverse_is_a HGNC:10643 ! CXCL6
+relationship: inverse_is_a HGNC:6025 ! CXCL8
+relationship: inverse_is_a HGNC:9240 ! PPBP
 
 [Term]
-id: FPLX:Cyclin
+id: FPLX:000130
 name: Cyclin
 synonym: "cyclin family" EXACT []
 synonym: "Cyclin" EXACT []
@@ -2113,34 +2133,34 @@ synonym: "cyclins" EXACT []
 xref: MEDSCAN:urn:agi-protfc:cyclin
 xref: NCIT:C17349
 xref: NEXTPROT-FAMILY:00815
-is_a: FPLX:root
-inverse_is_a: HGNC:CCNB1
-inverse_is_a: HGNC:CCNB2
-inverse_is_a: HGNC:CCNB3
-inverse_is_a: HGNC:CCNC
-inverse_is_a: HGNC:CCNF
-inverse_is_a: HGNC:CCNG1
-inverse_is_a: HGNC:CCNG2
-inverse_is_a: HGNC:CCNH
-inverse_is_a: HGNC:CCNI
-inverse_is_a: HGNC:CCNI2
-inverse_is_a: HGNC:CCNJ
-inverse_is_a: HGNC:CCNJL
-inverse_is_a: HGNC:CCNK
-inverse_is_a: HGNC:CCNL1
-inverse_is_a: HGNC:CCNL2
-inverse_is_a: HGNC:CCNO
-inverse_is_a: HGNC:CCNT1
-inverse_is_a: HGNC:CCNT2
-inverse_is_a: HGNC:CCNY
-inverse_is_a: HGNC:CCNYL1
-inverse_is_a: HGNC:CCNYL3
-inverse_is_a: FPLX:Cyclin_A
-inverse_is_a: FPLX:Cyclin_D
-inverse_is_a: FPLX:Cyclin_E
-
-[Term]
-id: FPLX:Cyclin_A
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1579 ! CCNB1
+relationship: inverse_is_a HGNC:1580 ! CCNB2
+relationship: inverse_is_a HGNC:18709 ! CCNB3
+relationship: inverse_is_a HGNC:1581 ! CCNC
+relationship: inverse_is_a HGNC:1591 ! CCNF
+relationship: inverse_is_a HGNC:1592 ! CCNG1
+relationship: inverse_is_a HGNC:1593 ! CCNG2
+relationship: inverse_is_a HGNC:1594 ! CCNH
+relationship: inverse_is_a HGNC:1595 ! CCNI
+relationship: inverse_is_a HGNC:33869 ! CCNI2
+relationship: inverse_is_a HGNC:23434 ! CCNJ
+relationship: inverse_is_a HGNC:25876 ! CCNJL
+relationship: inverse_is_a HGNC:1596 ! CCNK
+relationship: inverse_is_a HGNC:20569 ! CCNL1
+relationship: inverse_is_a HGNC:20570 ! CCNL2
+relationship: inverse_is_a HGNC:18576 ! CCNO
+relationship: inverse_is_a HGNC:1599 ! CCNT1
+relationship: inverse_is_a HGNC:1600 ! CCNT2
+relationship: inverse_is_a HGNC:23354 ! CCNY
+relationship: inverse_is_a HGNC:26868 ! CCNYL1
+relationship: inverse_is_a HGNC:33206 ! CCNYL3
+relationship: inverse_is_a FPLX:000131 ! Cyclin_A
+relationship: inverse_is_a FPLX:000132 ! Cyclin_D
+relationship: inverse_is_a FPLX:000133 ! Cyclin_E
+
+[Term]
+id: FPLX:000131
 name: Cyclin-A
 synonym: "Cyclin A" EXACT []
 synonym: "cyclin A" EXACT []
@@ -2151,12 +2171,12 @@ xref: RE:R-HSA-174074
 xref: RE:R-HSA-5696998
 xref: RE:R-HSA-6783051
 xref: RE:R-HSA-75202
-is_a: FPLX:Cyclin
-inverse_is_a: HGNC:CCNA1
-inverse_is_a: HGNC:CCNA2
+is_a: FPLX:000130 ! Cyclin
+relationship: inverse_is_a HGNC:1577 ! CCNA1
+relationship: inverse_is_a HGNC:1578 ! CCNA2
 
 [Term]
-id: FPLX:Cyclin_D
+id: FPLX:000132
 name: Cyclin-D
 synonym: "Cyclin D" EXACT []
 xref: BEL:"CCND Family"
@@ -2166,13 +2186,13 @@ xref: NEXTPROT-FAMILY:00818
 xref: RE:R-HSA-182582
 xref: RE:R-HSA-182700
 xref: RE:R-HSA-8938866
-is_a: FPLX:Cyclin
-inverse_is_a: HGNC:CCND1
-inverse_is_a: HGNC:CCND2
-inverse_is_a: HGNC:CCND3
+is_a: FPLX:000130 ! Cyclin
+relationship: inverse_is_a HGNC:1582 ! CCND1
+relationship: inverse_is_a HGNC:1583 ! CCND2
+relationship: inverse_is_a HGNC:1585 ! CCND3
 
 [Term]
-id: FPLX:Cyclin_E
+id: FPLX:000133
 name: Cyclin-E
 synonym: "cyclin E" EXACT []
 xref: BEL:"CCNE Family"
@@ -2183,54 +2203,54 @@ xref: RE:R-HSA-157462
 xref: RE:R-HSA-187493
 xref: RE:R-HSA-6813837
 xref: RE:R-HSA-68373
-is_a: FPLX:Cyclin
-inverse_is_a: HGNC:CCNE1
-inverse_is_a: HGNC:CCNE2
+is_a: FPLX:000130 ! Cyclin
+relationship: inverse_is_a HGNC:1589 ! CCNE1
+relationship: inverse_is_a HGNC:1590 ! CCNE2
 
 [Term]
-id: FPLX:Cyclophilin
+id: FPLX:000134
 name: Cyclophilin
 synonym: "cyclophilin" EXACT []
 synonym: "cyclophilins" EXACT []
 xref: BEL:"Cyclophilin Family"
 xref: MEDSCAN:urn:agi-protfc:cyclophilins
-is_a: FPLX:root
-inverse_is_a: HGNC:CWC27
-inverse_is_a: HGNC:PPIA
-inverse_is_a: HGNC:PPIB
-inverse_is_a: HGNC:PPIC
-inverse_is_a: HGNC:PPID
-inverse_is_a: HGNC:PPIE
-inverse_is_a: HGNC:PPIF
-inverse_is_a: HGNC:PPIH
-inverse_is_a: HGNC:PPIL1
-inverse_is_a: HGNC:PPIL2
-inverse_is_a: HGNC:PPIL3
-inverse_is_a: HGNC:PPIL4
-inverse_is_a: HGNC:PPIL6
-inverse_is_a: HGNC:PPWD1
-inverse_is_a: HGNC:PPIAL4A
-inverse_is_a: HGNC:PPIAL4C
-inverse_is_a: HGNC:PPIAL4G
-
-[Term]
-id: FPLX:Cytoplasmic_dynein
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10664 ! CWC27
+relationship: inverse_is_a HGNC:9253 ! PPIA
+relationship: inverse_is_a HGNC:9255 ! PPIB
+relationship: inverse_is_a HGNC:9256 ! PPIC
+relationship: inverse_is_a HGNC:9257 ! PPID
+relationship: inverse_is_a HGNC:9258 ! PPIE
+relationship: inverse_is_a HGNC:9259 ! PPIF
+relationship: inverse_is_a HGNC:14651 ! PPIH
+relationship: inverse_is_a HGNC:9260 ! PPIL1
+relationship: inverse_is_a HGNC:9261 ! PPIL2
+relationship: inverse_is_a HGNC:9262 ! PPIL3
+relationship: inverse_is_a HGNC:15702 ! PPIL4
+relationship: inverse_is_a HGNC:21557 ! PPIL6
+relationship: inverse_is_a HGNC:28954 ! PPWD1
+relationship: inverse_is_a HGNC:24369 ! PPIAL4A
+relationship: inverse_is_a HGNC:33995 ! PPIAL4C
+relationship: inverse_is_a HGNC:33996 ! PPIAL4G
+
+[Term]
+id: FPLX:000135
 name: Cytoplasmic-dynein
 synonym: "cytoplasmic dynein" EXACT []
 xref: BEL:"Cytoplasmic Dynein Complex"
 xref: GO:0005868
-is_a: FPLX:root
-has_part: HGNC:DYNC1H1
-has_part: HGNC:DYNC1I1
-has_part: HGNC:DYNC1I2
-has_part: HGNC:DYNC1LI1
-has_part: HGNC:DYNC1LI2
-has_part: HGNC:DYNLL1
-has_part: HGNC:DYNLRB1
-has_part: HGNC:DYNLRB2
-
-[Term]
-id: FPLX:DDR
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2961 ! DYNC1H1
+relationship: has_part HGNC:2963 ! DYNC1I1
+relationship: has_part HGNC:2964 ! DYNC1I2
+relationship: has_part HGNC:18745 ! DYNC1LI1
+relationship: has_part HGNC:2966 ! DYNC1LI2
+relationship: has_part HGNC:15476 ! DYNLL1
+relationship: has_part HGNC:15468 ! DYNLRB1
+relationship: has_part HGNC:15467 ! DYNLRB2
+
+[Term]
+id: FPLX:000136
 name: DDR
 synonym: "discoidin domain receptor family" EXACT []
 synonym: "discoidin domain receptors" EXACT []
@@ -2238,27 +2258,27 @@ synonym: "discoidin domain-containing receptor" EXACT []
 xref: BEL:"DDR Family"
 xref: MEDSCAN:urn:agi-aopfc:0000252
 xref: XFAM:PF08841
-is_a: FPLX:root
-inverse_is_a: HGNC:DDR1
-inverse_is_a: HGNC:DDR2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2730 ! DDR1
+relationship: inverse_is_a HGNC:2731 ! DDR2
 
 [Term]
-id: FPLX:Death_receptor
+id: FPLX:000137
 name: Death-receptor
 synonym: "death receptor" EXACT []
 synonym: "death receptors" EXACT []
 xref: GO:0005035
-is_a: FPLX:root
-inverse_is_a: HGNC:TNFRSF1A
-inverse_is_a: HGNC:TNFRSF1B
-inverse_is_a: HGNC:TNFRSF10A
-inverse_is_a: HGNC:TNFRSF10B
-inverse_is_a: HGNC:TNFRSF10C
-inverse_is_a: HGNC:TNFRSF10D
-inverse_is_a: HGNC:FAS
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11916 ! TNFRSF1A
+relationship: inverse_is_a HGNC:11917 ! TNFRSF1B
+relationship: inverse_is_a HGNC:11904 ! TNFRSF10A
+relationship: inverse_is_a HGNC:11905 ! TNFRSF10B
+relationship: inverse_is_a HGNC:11906 ! TNFRSF10C
+relationship: inverse_is_a HGNC:11907 ! TNFRSF10D
+relationship: inverse_is_a HGNC:11920 ! FAS
 
 [Term]
-id: FPLX:Desmoglein
+id: FPLX:000138
 name: Desmoglein
 synonym: "desmoglein" EXACT []
 synonym: "desmogleins" EXACT []
@@ -2267,14 +2287,14 @@ xref: IP:IPR009123
 xref: MEDSCAN:urn:agi-protfc:desmoglein
 xref: RE:R-HSA-6814694
 xref: RE:R-HSA-8847714
-is_a: FPLX:root
-inverse_is_a: HGNC:DSG1
-inverse_is_a: HGNC:DSG2
-inverse_is_a: HGNC:DSG3
-inverse_is_a: HGNC:DSG4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3048 ! DSG1
+relationship: inverse_is_a HGNC:3049 ! DSG2
+relationship: inverse_is_a HGNC:3050 ! DSG3
+relationship: inverse_is_a HGNC:21307 ! DSG4
 
 [Term]
-id: FPLX:DGC
+id: FPLX:000139
 name: DGC
 synonym: "DGC" EXACT []
 synonym: "dystrophin glycoprotein complex" EXACT []
@@ -2283,26 +2303,26 @@ synonym: "dystrophin-associated glycoprotein complex" EXACT []
 synonym: "dystrophin-glycoprotein complex" EXACT []
 xref: BEL:"Dystrophin Associated Glycoprotein Complex"
 xref: GO:0016010
-is_a: FPLX:root
-has_part: HGNC:DAG1
-has_part: HGNC:DMD
-has_part: HGNC:DTNA
-has_part: HGNC:DTNB
-has_part: HGNC:NOS1
-has_part: HGNC:SGCA
-has_part: HGNC:SGCB
-has_part: HGNC:SGCD
-has_part: HGNC:SGCE
-has_part: HGNC:SGCZ
-has_part: HGNC:SNTA1
-has_part: HGNC:SNTB1
-has_part: HGNC:SNTG1
-has_part: HGNC:SNTG2
-has_part: HGNC:SSPN
-has_part: HGNC:UTRN
-
-[Term]
-id: FPLX:DGK
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2666 ! DAG1
+relationship: has_part HGNC:2928 ! DMD
+relationship: has_part HGNC:3057 ! DTNA
+relationship: has_part HGNC:3058 ! DTNB
+relationship: has_part HGNC:7872 ! NOS1
+relationship: has_part HGNC:10805 ! SGCA
+relationship: has_part HGNC:10806 ! SGCB
+relationship: has_part HGNC:10807 ! SGCD
+relationship: has_part HGNC:10808 ! SGCE
+relationship: has_part HGNC:14075 ! SGCZ
+relationship: has_part HGNC:11167 ! SNTA1
+relationship: has_part HGNC:11168 ! SNTB1
+relationship: has_part HGNC:13740 ! SNTG1
+relationship: has_part HGNC:13741 ! SNTG2
+relationship: has_part HGNC:11322 ! SSPN
+relationship: has_part HGNC:12635 ! UTRN
+
+[Term]
+id: FPLX:000140
 name: DGK
 synonym: "DAG kinase" EXACT []
 synonym: "DGK" EXACT []
@@ -2312,20 +2332,20 @@ xref: BEL:"DGK Family"
 xref: ECCODE:2.7.1.107
 xref: IP:IPR000756
 xref: RE:R-HSA-426070
-is_a: FPLX:root
-inverse_is_a: HGNC:DGKA
-inverse_is_a: HGNC:DGKB
-inverse_is_a: HGNC:DGKD
-inverse_is_a: HGNC:DGKG
-inverse_is_a: HGNC:DGKH
-inverse_is_a: HGNC:DGKQ
-inverse_is_a: HGNC:DGKZ
-inverse_is_a: HGNC:DGKE
-inverse_is_a: HGNC:DGKI
-inverse_is_a: HGNC:DGKK
-
-[Term]
-id: FPLX:DNA_polymerase_delta
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2849 ! DGKA
+relationship: inverse_is_a HGNC:2850 ! DGKB
+relationship: inverse_is_a HGNC:2851 ! DGKD
+relationship: inverse_is_a HGNC:2853 ! DGKG
+relationship: inverse_is_a HGNC:2854 ! DGKH
+relationship: inverse_is_a HGNC:2856 ! DGKQ
+relationship: inverse_is_a HGNC:2857 ! DGKZ
+relationship: inverse_is_a HGNC:2852 ! DGKE
+relationship: inverse_is_a HGNC:2855 ! DGKI
+relationship: inverse_is_a HGNC:32395 ! DGKK
+
+[Term]
+id: FPLX:000141
 name: DNA-polymerase-delta
 synonym: "DNA polymerase delta" EXACT []
 synonym: "DNA polymerase δ" EXACT []
@@ -2337,14 +2357,14 @@ xref: BEL:"DNA Polymerase delta Complex"
 xref: GO:0043625
 xref: NCIT:C16511
 xref: RE:R-HSA-68450
-is_a: FPLX:root
-has_part: HGNC:POLD1
-has_part: HGNC:POLD2
-has_part: HGNC:POLD3
-has_part: HGNC:POLD4
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9175 ! POLD1
+relationship: has_part HGNC:9176 ! POLD2
+relationship: has_part HGNC:20932 ! POLD3
+relationship: has_part HGNC:14106 ! POLD4
 
 [Term]
-id: FPLX:DNM
+id: FPLX:000142
 name: DNM
 synonym: "dynamin family" EXACT []
 synonym: "dynamin" EXACT []
@@ -2353,13 +2373,13 @@ xref: RE:R-HSA-2213185
 xref: RE:R-HSA-446847
 xref: RE:R-HSA-8868235
 xref: RE:R-HSA-8868609
-is_a: FPLX:root
-inverse_is_a: HGNC:DNM1
-inverse_is_a: HGNC:DNM2
-inverse_is_a: HGNC:DNM3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2972 ! DNM1
+relationship: inverse_is_a HGNC:2974 ! DNM2
+relationship: inverse_is_a HGNC:29125 ! DNM3
 
 [Term]
-id: FPLX:DRD
+id: FPLX:000143
 name: DRD
 synonym: "dopamine receptor" EXACT []
 synonym: "dopamine receptors" EXACT []
@@ -2367,27 +2387,27 @@ xref: BEL:"DRD Family"
 xref: GO:0004952
 xref: IP:IPR000929
 xref: NCIT:C17066
-is_a: FPLX:root
-inverse_is_a: HGNC:DRD1
-inverse_is_a: HGNC:DRD2
-inverse_is_a: HGNC:DRD3
-inverse_is_a: HGNC:DRD4
-inverse_is_a: HGNC:DRD5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3020 ! DRD1
+relationship: inverse_is_a HGNC:3023 ! DRD2
+relationship: inverse_is_a HGNC:3024 ! DRD3
+relationship: inverse_is_a HGNC:3025 ! DRD4
+relationship: inverse_is_a HGNC:3026 ! DRD5
 
 [Term]
-id: FPLX:DUSP
+id: FPLX:000144
 name: DUSP
 synonym: "DUSP" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:DUSP1
-inverse_is_a: HGNC:DUSP2
-inverse_is_a: HGNC:DUSP3
-inverse_is_a: HGNC:DUSP4
-inverse_is_a: HGNC:DUSP5
-inverse_is_a: HGNC:DUSP6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3064 ! DUSP1
+relationship: inverse_is_a HGNC:3068 ! DUSP2
+relationship: inverse_is_a HGNC:3069 ! DUSP3
+relationship: inverse_is_a HGNC:3070 ! DUSP4
+relationship: inverse_is_a HGNC:3071 ! DUSP5
+relationship: inverse_is_a HGNC:3072 ! DUSP6
 
 [Term]
-id: FPLX:DVL
+id: FPLX:000145
 name: DVL
 synonym: "dishevelled" EXACT []
 synonym: "Dvl" EXACT []
@@ -2402,52 +2422,52 @@ xref: RE:R-HSA-3858467
 xref: RE:R-HSA-3858479
 xref: RE:R-HSA-4652685
 xref: SIGNOR:SIGNOR-PF10
-is_a: FPLX:root
-inverse_is_a: HGNC:DVL1
-inverse_is_a: HGNC:DVL2
-inverse_is_a: HGNC:DVL3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3084 ! DVL1
+relationship: inverse_is_a HGNC:3086 ! DVL2
+relationship: inverse_is_a HGNC:3087 ! DVL3
 
 [Term]
-id: FPLX:DYRK
+id: FPLX:000146
 name: DYRK
 synonym: "DYRK" EXACT []
 xref: NEXTPROT-FAMILY:03091
-is_a: FPLX:root
-inverse_is_a: HGNC:DYRK1A
-inverse_is_a: HGNC:DYRK1B
-inverse_is_a: HGNC:DYRK2
-inverse_is_a: HGNC:DYRK3
-inverse_is_a: HGNC:DYRK4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3091 ! DYRK1A
+relationship: inverse_is_a HGNC:3092 ! DYRK1B
+relationship: inverse_is_a HGNC:3093 ! DYRK2
+relationship: inverse_is_a HGNC:3094 ! DYRK3
+relationship: inverse_is_a HGNC:3095 ! DYRK4
 
 [Term]
-id: FPLX:E2F
+id: FPLX:000147
 name: E2F
 synonym: "E2F" EXACT []
 xref: BEL:"E2F Family"
 xref: IP:IPR015633
 xref: MEDSCAN:urn:agi-aopfc:0000099
 xref: MEDSCAN:urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388
-is_a: FPLX:root
-inverse_is_a: HGNC:E2F1
-inverse_is_a: HGNC:E2F2
-inverse_is_a: HGNC:E2F3
-inverse_is_a: HGNC:E2F4
-inverse_is_a: HGNC:E2F5
-inverse_is_a: HGNC:E2F6
-inverse_is_a: HGNC:E2F7
-inverse_is_a: HGNC:E2F8
-
-[Term]
-id: FPLX:E3_Ub_ligase
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3113 ! E2F1
+relationship: inverse_is_a HGNC:3114 ! E2F2
+relationship: inverse_is_a HGNC:3115 ! E2F3
+relationship: inverse_is_a HGNC:3118 ! E2F4
+relationship: inverse_is_a HGNC:3119 ! E2F5
+relationship: inverse_is_a HGNC:3120 ! E2F6
+relationship: inverse_is_a HGNC:23820 ! E2F7
+relationship: inverse_is_a HGNC:24727 ! E2F8
+
+[Term]
+id: FPLX:000148
 name: E3-Ub-ligase
 synonym: "E3 ubiquitin ligase" EXACT []
 synonym: "E3" EXACT []
 xref: XFAM:PF12483
 xref: RE:R-HSA-976075
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:EDN
+id: FPLX:000149
 name: EDN
 synonym: "endothelin" EXACT []
 synonym: "endothelins" EXACT []
@@ -2458,110 +2478,110 @@ xref: IP:IPR020475
 xref: MEDSCAN:urn:agi-protfc:endothelin
 xref: XFAM:PF00322
 xref: RE:R-HSA-388544
-is_a: FPLX:root
-inverse_is_a: HGNC:EDN1
-inverse_is_a: HGNC:EDN2
-inverse_is_a: HGNC:EDN3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3176 ! EDN1
+relationship: inverse_is_a HGNC:3177 ! EDN2
+relationship: inverse_is_a HGNC:3178 ! EDN3
 
 [Term]
-id: FPLX:EGFR_ligand
+id: FPLX:000150
 name: EGFR-ligand
 synonym: "EGFR ligand" EXACT []
 synonym: "EGFR ligands" EXACT []
 xref: BEL:"EGFR Ligand Family"
 xref: GO:0005154
-is_a: FPLX:root
-inverse_is_a: HGNC:AREG
-inverse_is_a: HGNC:EGF
-inverse_is_a: HGNC:TGFA
-inverse_is_a: HGNC:HBEGF
-inverse_is_a: HGNC:BTC
-inverse_is_a: HGNC:EREG
-inverse_is_a: HGNC:EPGN
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:651 ! AREG
+relationship: inverse_is_a HGNC:3229 ! EGF
+relationship: inverse_is_a HGNC:11765 ! TGFA
+relationship: inverse_is_a HGNC:3059 ! HBEGF
+relationship: inverse_is_a HGNC:1121 ! BTC
+relationship: inverse_is_a HGNC:3443 ! EREG
+relationship: inverse_is_a HGNC:17470 ! EPGN
 
 [Term]
-id: FPLX:EGR
+id: FPLX:000151
 name: EGR
 synonym: "early growth response proteins" EXACT []
 synonym: "EGR" EXACT []
 xref: BEL:"EGR Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:EGR1
-inverse_is_a: HGNC:EGR2
-inverse_is_a: HGNC:EGR3
-inverse_is_a: HGNC:EGR4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3238 ! EGR1
+relationship: inverse_is_a HGNC:3239 ! EGR2
+relationship: inverse_is_a HGNC:3240 ! EGR3
+relationship: inverse_is_a HGNC:3241 ! EGR4
 
 [Term]
-id: FPLX:EIF2B
+id: FPLX:000152
 name: EIF2B
 synonym: "EIF2B" EXACT []
 synonym: "eIF2B" EXACT []
 xref: BEL:"EIF2B Complex"
 xref: NCIT:C18162
 xref: RE:R-HSA-72526
-is_a: FPLX:root
-has_part: HGNC:EIF2B1
-has_part: HGNC:EIF2B2
-has_part: HGNC:EIF2B3
-has_part: HGNC:EIF2B4
-has_part: HGNC:EIF2B5
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3257 ! EIF2B1
+relationship: has_part HGNC:3258 ! EIF2B2
+relationship: has_part HGNC:3259 ! EIF2B3
+relationship: has_part HGNC:3260 ! EIF2B4
+relationship: has_part HGNC:3261 ! EIF2B5
 
 [Term]
-id: FPLX:EIF4A
+id: FPLX:000153
 name: EIF4A
 synonym: "eIF4A" EXACT []
 synonym: "eukaryotic initiation factor-4A" EXACT []
 xref: BEL:"EIF4A Family"
 xref: NEXTPROT-FAMILY:00921
 xref: RE:R-HSA-429842
-is_a: FPLX:root
-inverse_is_a: HGNC:EIF4A1
-inverse_is_a: HGNC:EIF4A2
-inverse_is_a: HGNC:EIF4A3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3282 ! EIF4A1
+relationship: inverse_is_a HGNC:3284 ! EIF4A2
+relationship: inverse_is_a HGNC:18683 ! EIF4A3
 
 [Term]
-id: FPLX:EIF4EBP
+id: FPLX:000154
 name: EIF4EBP
 synonym: "4EBP" EXACT []
 synonym: "initiation factor 4E binding proteins" EXACT []
 xref: BEL:"EIF4EBP Family"
 xref: GO:0008190
 xref: IP:IPR008606
-is_a: FPLX:root
-inverse_is_a: HGNC:EIF4EBP1
-inverse_is_a: HGNC:EIF4EBP2
-inverse_is_a: HGNC:EIF4EBP3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3288 ! EIF4EBP1
+relationship: inverse_is_a HGNC:3289 ! EIF4EBP2
+relationship: inverse_is_a HGNC:3290 ! EIF4EBP3
 
 [Term]
-id: FPLX:EIF4G
+id: FPLX:000155
 name: EIF4G
 synonym: "eIF4G" EXACT []
 xref: XFAM:PF02854
 xref: RE:R-HSA-1678828
-is_a: FPLX:root
-inverse_is_a: HGNC:EIF4G1
-inverse_is_a: HGNC:EIF4G2
-inverse_is_a: HGNC:EIF4G3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3296 ! EIF4G1
+relationship: inverse_is_a HGNC:3297 ! EIF4G2
+relationship: inverse_is_a HGNC:3298 ! EIF4G3
 
 [Term]
-id: FPLX:ELA
+id: FPLX:000156
 name: ELA
 synonym: "elastase" EXACT []
 xref: BEL:"ELA Family"
 xref: NEXTPROT-FAMILY:02762
-is_a: FPLX:root
-inverse_is_a: HGNC:AZU1
-inverse_is_a: HGNC:CELA1
-inverse_is_a: HGNC:CELA2A
-inverse_is_a: HGNC:CELA2B
-inverse_is_a: HGNC:CELA3A
-inverse_is_a: HGNC:CELA3B
-inverse_is_a: HGNC:CTRC
-inverse_is_a: HGNC:ELANE
-inverse_is_a: HGNC:PRTN3
-
-[Term]
-id: FPLX:ENO
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:913 ! AZU1
+relationship: inverse_is_a HGNC:3308 ! CELA1
+relationship: inverse_is_a HGNC:24609 ! CELA2A
+relationship: inverse_is_a HGNC:29995 ! CELA2B
+relationship: inverse_is_a HGNC:15944 ! CELA3A
+relationship: inverse_is_a HGNC:15945 ! CELA3B
+relationship: inverse_is_a HGNC:2523 ! CTRC
+relationship: inverse_is_a HGNC:3309 ! ELANE
+relationship: inverse_is_a HGNC:9495 ! PRTN3
+
+[Term]
+id: FPLX:000157
 name: ENO
 synonym: "enolase" EXACT []
 xref: BEL:"ENO Family"
@@ -2569,14 +2589,14 @@ xref: IP:IPR000941
 xref: IP:IPR020810
 xref: IP:IPR020811
 xref: NEXTPROT-FAMILY:01112
-is_a: FPLX:root
-inverse_is_a: HGNC:ENO1
-inverse_is_a: HGNC:ENO2
-inverse_is_a: HGNC:ENO3
-inverse_is_a: HGNC:ENO4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3350 ! ENO1
+relationship: inverse_is_a HGNC:3353 ! ENO2
+relationship: inverse_is_a HGNC:3354 ! ENO3
+relationship: inverse_is_a HGNC:31670 ! ENO4
 
 [Term]
-id: FPLX:Ephrin_receptor
+id: FPLX:000158
 name: Ephrin-receptor
 synonym: "Eph receptor" EXACT []
 synonym: "Eph receptors" EXACT []
@@ -2588,51 +2608,51 @@ xref: IP:IPR016257
 xref: IP:IPR027936
 xref: NCIT:C18606
 xref: NEXTPROT-FAMILY:03124
-is_a: FPLX:root
-inverse_is_a: HGNC:EPHA1
-inverse_is_a: HGNC:EPHA2
-inverse_is_a: HGNC:EPHA3
-inverse_is_a: HGNC:EPHA4
-inverse_is_a: HGNC:EPHA5
-inverse_is_a: HGNC:EPHA6
-inverse_is_a: HGNC:EPHA7
-inverse_is_a: HGNC:EPHA8
-inverse_is_a: HGNC:EPHB1
-inverse_is_a: HGNC:EPHB2
-inverse_is_a: HGNC:EPHB3
-inverse_is_a: HGNC:EPHB4
-inverse_is_a: HGNC:EPHB6
-inverse_is_a: HGNC:EPHA10
-
-[Term]
-id: FPLX:EPN
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3385 ! EPHA1
+relationship: inverse_is_a HGNC:3386 ! EPHA2
+relationship: inverse_is_a HGNC:3387 ! EPHA3
+relationship: inverse_is_a HGNC:3388 ! EPHA4
+relationship: inverse_is_a HGNC:3389 ! EPHA5
+relationship: inverse_is_a HGNC:19296 ! EPHA6
+relationship: inverse_is_a HGNC:3390 ! EPHA7
+relationship: inverse_is_a HGNC:3391 ! EPHA8
+relationship: inverse_is_a HGNC:3392 ! EPHB1
+relationship: inverse_is_a HGNC:3393 ! EPHB2
+relationship: inverse_is_a HGNC:3394 ! EPHB3
+relationship: inverse_is_a HGNC:3395 ! EPHB4
+relationship: inverse_is_a HGNC:3396 ! EPHB6
+relationship: inverse_is_a HGNC:19987 ! EPHA10
+
+[Term]
+id: FPLX:000159
 name: EPN
 synonym: "epsin" EXACT []
 synonym: "epsins" EXACT []
 xref: BEL:"EPN Family"
 xref: NEXTPROT-FAMILY:01121
-is_a: FPLX:root
-inverse_is_a: HGNC:EPN1
-inverse_is_a: HGNC:EPN2
-inverse_is_a: HGNC:EPN3
-inverse_is_a: HGNC:CLINT1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:21604 ! EPN1
+relationship: inverse_is_a HGNC:18639 ! EPN2
+relationship: inverse_is_a HGNC:18235 ! EPN3
+relationship: inverse_is_a HGNC:23186 ! CLINT1
 
 [Term]
-id: FPLX:ERBB
+id: FPLX:000160
 name: ERBB
 synonym: "ErbB" EXACT []
 synonym: "erbB" EXACT []
 xref: BEL:"EGFR/ERBB Family"
 xref: IP:IPR016245
 xref: NCIT:C17763
-is_a: FPLX:root
-inverse_is_a: HGNC:EGFR
-inverse_is_a: HGNC:ERBB2
-inverse_is_a: HGNC:ERBB3
-inverse_is_a: HGNC:ERBB4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3236 ! EGFR
+relationship: inverse_is_a HGNC:3430 ! ERBB2
+relationship: inverse_is_a HGNC:3431 ! ERBB3
+relationship: inverse_is_a HGNC:3432 ! ERBB4
 
 [Term]
-id: FPLX:ERK
+id: FPLX:000161
 name: ERK
 synonym: "ERK 1/2" EXACT []
 synonym: "ERK MAPK" EXACT []
@@ -2666,22 +2686,22 @@ xref: RE:R-HSA-5674341
 xref: RE:R-HSA-5675361
 xref: RE:R-HSA-5675363
 xref: SIGNOR:SIGNOR-PF1
-is_a: FPLX:MAPK
-inverse_is_a: HGNC:MAPK1
-inverse_is_a: HGNC:MAPK3
+is_a: FPLX:000283 ! MAPK
+relationship: inverse_is_a HGNC:6871 ! MAPK1
+relationship: inverse_is_a HGNC:6877 ! MAPK3
 
 [Term]
-id: FPLX:ESR
+id: FPLX:000162
 name: ESR
 synonym: "ER" EXACT []
 synonym: "ESR" EXACT []
 xref: BEL:"ESR Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:ESR1
-inverse_is_a: HGNC:ESR2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3467 ! ESR1
+relationship: inverse_is_a HGNC:3468 ! ESR2
 
 [Term]
-id: FPLX:ETS
+id: FPLX:000163
 name: ETS
 synonym: "ETS" EXACT []
 xref: BEL:"ETS Family"
@@ -2690,12 +2710,12 @@ xref: XFAM:PF00178
 xref: RE:R-HSA-3132719
 xref: RE:R-HSA-3132724
 xref: RE:R-HSA-3200029
-is_a: FPLX:root
-inverse_is_a: HGNC:ETS1
-inverse_is_a: HGNC:ETS2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3488 ! ETS1
+relationship: inverse_is_a HGNC:3489 ! ETS2
 
 [Term]
-id: FPLX:EXOC
+id: FPLX:000164
 name: EXOC
 synonym: "EXOC" EXACT []
 synonym: "exocyst complex" EXACT []
@@ -2703,58 +2723,58 @@ synonym: "exocyst" EXACT []
 xref: GO:0000145
 xref: RE:R-HSA-264974
 xref: RE:R-HSA-5623453
-is_a: FPLX:root
-has_part: HGNC:EXOC1
-has_part: HGNC:EXOC2
-has_part: HGNC:EXOC3
-has_part: HGNC:EXOC4
-has_part: HGNC:EXOC5
-has_part: HGNC:EXOC6
-has_part: HGNC:EXOC7
-has_part: HGNC:EXOC8
-
-[Term]
-id: FPLX:EXT
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:30380 ! EXOC1
+relationship: has_part HGNC:24968 ! EXOC2
+relationship: has_part HGNC:30378 ! EXOC3
+relationship: has_part HGNC:30389 ! EXOC4
+relationship: has_part HGNC:10696 ! EXOC5
+relationship: has_part HGNC:23196 ! EXOC6
+relationship: has_part HGNC:23214 ! EXOC7
+relationship: has_part HGNC:24659 ! EXOC8
+
+[Term]
+id: FPLX:000165
 name: EXT
 synonym: "Exostosin glycosyltransferase family" EXACT []
 synonym: "exostosin glycosyltransferase family" EXACT []
 synonym: "EXT" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:EXTL1
-inverse_is_a: HGNC:EXTL2
-inverse_is_a: HGNC:EXTL3
-inverse_is_a: HGNC:EXT1
-inverse_is_a: HGNC:EXT2
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:3515 ! EXTL1
+relationship: inverse_is_a HGNC:3516 ! EXTL2
+relationship: inverse_is_a HGNC:3518 ! EXTL3
+relationship: inverse_is_a HGNC:3512 ! EXT1
+relationship: inverse_is_a HGNC:3513 ! EXT2
 
 [Term]
-id: FPLX:FANC
+id: FPLX:000166
 name: FANC
 synonym: "FANC proteins" EXACT []
 synonym: "FANC" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:FANCA
-inverse_is_a: HGNC:FANCB
-inverse_is_a: HGNC:FANCC
-inverse_is_a: HGNC:BRCA2
-inverse_is_a: HGNC:FANCD2
-inverse_is_a: HGNC:FANCE
-inverse_is_a: HGNC:FANCF
-inverse_is_a: HGNC:FANCG
-inverse_is_a: HGNC:FANCI
-inverse_is_a: HGNC:BRIP1
-inverse_is_a: HGNC:FANCL
-inverse_is_a: HGNC:FANCM
-inverse_is_a: HGNC:PALB2
-inverse_is_a: HGNC:RAD51C
-inverse_is_a: HGNC:SLX4
-inverse_is_a: HGNC:ERCC4
-inverse_is_a: HGNC:RAD51
-inverse_is_a: HGNC:BRCA1
-inverse_is_a: HGNC:UBE2T
-inverse_is_a: HGNC:XRCC2
-
-[Term]
-id: FPLX:FGF
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3582 ! FANCA
+relationship: inverse_is_a HGNC:3583 ! FANCB
+relationship: inverse_is_a HGNC:3584 ! FANCC
+relationship: inverse_is_a HGNC:1101 ! BRCA2
+relationship: inverse_is_a HGNC:3585 ! FANCD2
+relationship: inverse_is_a HGNC:3586 ! FANCE
+relationship: inverse_is_a HGNC:3587 ! FANCF
+relationship: inverse_is_a HGNC:3588 ! FANCG
+relationship: inverse_is_a HGNC:25568 ! FANCI
+relationship: inverse_is_a HGNC:20473 ! BRIP1
+relationship: inverse_is_a HGNC:20748 ! FANCL
+relationship: inverse_is_a HGNC:23168 ! FANCM
+relationship: inverse_is_a HGNC:26144 ! PALB2
+relationship: inverse_is_a HGNC:9820 ! RAD51C
+relationship: inverse_is_a HGNC:23845 ! SLX4
+relationship: inverse_is_a HGNC:3436 ! ERCC4
+relationship: inverse_is_a HGNC:9817 ! RAD51
+relationship: inverse_is_a HGNC:1100 ! BRCA1
+relationship: inverse_is_a HGNC:25009 ! UBE2T
+relationship: inverse_is_a HGNC:12829 ! XRCC2
+
+[Term]
+id: FPLX:000167
 name: FGF
 synonym: "FGF" EXACT []
 xref: BEL:"FGF Family"
@@ -2762,32 +2782,32 @@ xref: GO:0005162
 xref: IP:IPR002209
 xref: XFAM:PF00167
 xref: SIGNOR:SIGNOR-PF8
-is_a: FPLX:root
-inverse_is_a: HGNC:FGF1
-inverse_is_a: HGNC:FGF2
-inverse_is_a: HGNC:FGF3
-inverse_is_a: HGNC:FGF4
-inverse_is_a: HGNC:FGF5
-inverse_is_a: HGNC:FGF6
-inverse_is_a: HGNC:FGF7
-inverse_is_a: HGNC:FGF8
-inverse_is_a: HGNC:FGF9
-inverse_is_a: HGNC:FGF10
-inverse_is_a: HGNC:FGF11
-inverse_is_a: HGNC:FGF12
-inverse_is_a: HGNC:FGF13
-inverse_is_a: HGNC:FGF14
-inverse_is_a: HGNC:FGF16
-inverse_is_a: HGNC:FGF17
-inverse_is_a: HGNC:FGF18
-inverse_is_a: HGNC:FGF19
-inverse_is_a: HGNC:FGF20
-inverse_is_a: HGNC:FGF21
-inverse_is_a: HGNC:FGF22
-inverse_is_a: HGNC:FGF23
-
-[Term]
-id: FPLX:FGFR
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3665 ! FGF1
+relationship: inverse_is_a HGNC:3676 ! FGF2
+relationship: inverse_is_a HGNC:3681 ! FGF3
+relationship: inverse_is_a HGNC:3682 ! FGF4
+relationship: inverse_is_a HGNC:3683 ! FGF5
+relationship: inverse_is_a HGNC:3684 ! FGF6
+relationship: inverse_is_a HGNC:3685 ! FGF7
+relationship: inverse_is_a HGNC:3686 ! FGF8
+relationship: inverse_is_a HGNC:3687 ! FGF9
+relationship: inverse_is_a HGNC:3666 ! FGF10
+relationship: inverse_is_a HGNC:3667 ! FGF11
+relationship: inverse_is_a HGNC:3668 ! FGF12
+relationship: inverse_is_a HGNC:3670 ! FGF13
+relationship: inverse_is_a HGNC:3671 ! FGF14
+relationship: inverse_is_a HGNC:3672 ! FGF16
+relationship: inverse_is_a HGNC:3673 ! FGF17
+relationship: inverse_is_a HGNC:3674 ! FGF18
+relationship: inverse_is_a HGNC:3675 ! FGF19
+relationship: inverse_is_a HGNC:3677 ! FGF20
+relationship: inverse_is_a HGNC:3678 ! FGF21
+relationship: inverse_is_a HGNC:3679 ! FGF22
+relationship: inverse_is_a HGNC:3680 ! FGF23
+
+[Term]
+id: FPLX:000168
 name: FGFR
 synonym: "FGFR" EXACT []
 xref: BEL:"FGFR Family"
@@ -2795,15 +2815,15 @@ xref: GO:0005007
 xref: IP:IPR016248
 xref: NCIT:C17297
 xref: SIGNOR:SIGNOR-PF23
-is_a: FPLX:root
-inverse_is_a: HGNC:FGFR1
-inverse_is_a: HGNC:FGFR2
-inverse_is_a: HGNC:FGFR3
-inverse_is_a: HGNC:FGFR4
-inverse_is_a: HGNC:FGFRL1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3688 ! FGFR1
+relationship: inverse_is_a HGNC:3689 ! FGFR2
+relationship: inverse_is_a HGNC:3690 ! FGFR3
+relationship: inverse_is_a HGNC:3691 ! FGFR4
+relationship: inverse_is_a HGNC:3693 ! FGFRL1
 
 [Term]
-id: FPLX:Fibrinogen
+id: FPLX:000169
 name: Fibrinogen
 synonym: "fibrinogen" EXACT []
 xref: BEL:"Fibrinogen Complex"
@@ -2816,13 +2836,13 @@ xref: RE:R-HSA-139934
 xref: RE:R-HSA-140586
 xref: RE:R-HSA-140919
 xref: RE:R-HSA-8870680
-is_a: FPLX:root
-has_part: HGNC:FGA
-has_part: HGNC:FGB
-has_part: HGNC:FGG
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3661 ! FGA
+relationship: has_part HGNC:3662 ! FGB
+relationship: has_part HGNC:3694 ! FGG
 
 [Term]
-id: FPLX:FLOT
+id: FPLX:000170
 name: FLOT
 synonym: "flotillin" EXACT []
 xref: BEL:"FLOT Family"
@@ -2831,49 +2851,49 @@ xref: IP:IPR031905
 xref: MEDSCAN:urn:agi-protfc:flotillin
 xref: XFAM:PF15975
 xref: RE:R-HSA-8849894
-is_a: FPLX:root
-inverse_is_a: HGNC:FLOT1
-inverse_is_a: HGNC:FLOT2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3757 ! FLOT1
+relationship: inverse_is_a HGNC:3758 ! FLOT2
 
 [Term]
-id: FPLX:FLRT
+id: FPLX:000171
 name: FLRT
 synonym: "FLRT family" EXACT []
 synonym: "Flrt family" EXACT []
 synonym: "FLRT proteins" EXACT []
 xref: BEL:"FLRT Family"
 xref: RE:R-HSA-5656056
-is_a: FPLX:root
-inverse_is_a: HGNC:FLRT1
-inverse_is_a: HGNC:FLRT2
-inverse_is_a: HGNC:FLRT3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3760 ! FLRT1
+relationship: inverse_is_a HGNC:3761 ! FLRT2
+relationship: inverse_is_a HGNC:3762 ! FLRT3
 
 [Term]
-id: FPLX:FNT
+id: FPLX:000172
 name: FNT
 synonym: "farnesyltransferase" EXACT []
 synonym: "FTase" EXACT []
 synonym: "protein farnesyltransferase" EXACT []
 xref: ECCODE:2.5.1.58
 xref: RE:R-HSA-2530496
-is_a: FPLX:root
-has_part: HGNC:FNTA
-has_part: HGNC:FNTB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3782 ! FNTA
+relationship: has_part HGNC:3785 ! FNTB
 
 [Term]
-id: FPLX:FOS_family
+id: FPLX:000173
 name: FOS-family
 synonym: "FOS" EXACT []
 synonym: "Fos" EXACT []
 xref: NEXTPROT-FAMILY:00408
-part_of: FPLX:AP1
-inverse_is_a: HGNC:FOS
-inverse_is_a: HGNC:FOSB
-inverse_is_a: HGNC:FOSL1
-inverse_is_a: HGNC:FOSL2
+relationship: part_of FPLX:000048 ! AP1
+relationship: inverse_is_a HGNC:3796 ! FOS
+relationship: inverse_is_a HGNC:3797 ! FOSB
+relationship: inverse_is_a HGNC:13718 ! FOSL1
+relationship: inverse_is_a HGNC:3798 ! FOSL2
 
 [Term]
-id: FPLX:FOXO
+id: FPLX:000174
 name: FOXO
 synonym: "FOXO" EXACT []
 synonym: "FoxO" EXACT []
@@ -2881,49 +2901,49 @@ xref: BEL:"FOXO Family"
 xref: IP:IPR032067
 xref: NCIT:C118892
 xref: SIGNOR:SIGNOR-PF27
-is_a: FPLX:root
-inverse_is_a: HGNC:FOXO1
-inverse_is_a: HGNC:FOXO3
-inverse_is_a: HGNC:FOXO4
-inverse_is_a: HGNC:FOXO6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3819 ! FOXO1
+relationship: inverse_is_a HGNC:3821 ! FOXO3
+relationship: inverse_is_a HGNC:7139 ! FOXO4
+relationship: inverse_is_a HGNC:24814 ! FOXO6
 
 [Term]
-id: FPLX:FSH
+id: FPLX:000175
 name: FSH
 synonym: "follicle-stimulating hormone" EXACT []
 synonym: "FSH" EXACT []
 xref: BEL:"Follicle Stimulating Hormone Complex"
 xref: GO:0016914
 xref: RE:R-HSA-378947
-is_a: FPLX:root
-has_part: HGNC:CGA
-has_part: HGNC:FSHB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1885 ! CGA
+relationship: has_part HGNC:3964 ! FSHB
 
 [Term]
-id: FPLX:FUT
+id: FPLX:000176
 name: FUT
 synonym: "Fucosyltransferase" EXACT []
 synonym: "Fucosyltransferases" EXACT []
 synonym: "fucosyltransferase" EXACT []
 synonym: "fucosyltransferases" EXACT []
 synonym: "FUT" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:FUT1
-inverse_is_a: HGNC:FUT2
-inverse_is_a: HGNC:FUT3
-inverse_is_a: HGNC:FUT4
-inverse_is_a: HGNC:FUT5
-inverse_is_a: HGNC:FUT6
-inverse_is_a: HGNC:FUT7
-inverse_is_a: HGNC:FUT8
-inverse_is_a: HGNC:FUT9
-inverse_is_a: HGNC:FUT10
-inverse_is_a: HGNC:FUT11
-inverse_is_a: HGNC:POFUT1
-inverse_is_a: HGNC:POFUT2
-
-[Term]
-id: FPLX:FZD
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:4012 ! FUT1
+relationship: inverse_is_a HGNC:4013 ! FUT2
+relationship: inverse_is_a HGNC:4014 ! FUT3
+relationship: inverse_is_a HGNC:4015 ! FUT4
+relationship: inverse_is_a HGNC:4016 ! FUT5
+relationship: inverse_is_a HGNC:4017 ! FUT6
+relationship: inverse_is_a HGNC:4018 ! FUT7
+relationship: inverse_is_a HGNC:4019 ! FUT8
+relationship: inverse_is_a HGNC:4020 ! FUT9
+relationship: inverse_is_a HGNC:19234 ! FUT10
+relationship: inverse_is_a HGNC:19233 ! FUT11
+relationship: inverse_is_a HGNC:14988 ! POFUT1
+relationship: inverse_is_a HGNC:14683 ! POFUT2
+
+[Term]
+id: FPLX:000177
 name: FZD
 synonym: "Fz" EXACT []
 synonym: "FZD" EXACT []
@@ -2933,28 +2953,28 @@ xref: MEDSCAN:urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267
 xref: XFAM:PF01534
 xref: RE:R-HSA-517388
 xref: SIGNOR:SIGNOR-PF11
-is_a: FPLX:root
-inverse_is_a: HGNC:FZD1
-inverse_is_a: HGNC:FZD10
-inverse_is_a: HGNC:FZD2
-inverse_is_a: HGNC:FZD3
-inverse_is_a: HGNC:FZD4
-inverse_is_a: HGNC:FZD5
-inverse_is_a: HGNC:FZD6
-inverse_is_a: HGNC:FZD7
-inverse_is_a: HGNC:FZD8
-inverse_is_a: HGNC:FZD9
-
-[Term]
-id: FPLX:F_actin
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4038 ! FZD1
+relationship: inverse_is_a HGNC:4039 ! FZD10
+relationship: inverse_is_a HGNC:4040 ! FZD2
+relationship: inverse_is_a HGNC:4041 ! FZD3
+relationship: inverse_is_a HGNC:4042 ! FZD4
+relationship: inverse_is_a HGNC:4043 ! FZD5
+relationship: inverse_is_a HGNC:4044 ! FZD6
+relationship: inverse_is_a HGNC:4045 ! FZD7
+relationship: inverse_is_a HGNC:4046 ! FZD8
+relationship: inverse_is_a HGNC:4047 ! FZD9
+
+[Term]
+id: FPLX:000178
 name: F-actin
 synonym: "F-actin" EXACT []
 xref: GO:0031941
 xref: MEDSCAN:urn:agi-protfc:F-actin-binding%20protein
-is_a: FPLX:Actin
+is_a: FPLX:000009 ! Actin
 
 [Term]
-id: FPLX:GABR
+id: FPLX:000179
 name: GABR
 synonym: "GABA receptor" EXACT []
 synonym: "GABA receptors" EXACT []
@@ -2963,55 +2983,55 @@ synonym: "gamma-aminobutyric-acid A receptor" EXACT []
 synonym: "γ-aminobutyric-acid A receptor" EXACT []
 xref: BEL:"GABR Family"
 xref: GO:0004890
-is_a: FPLX:root
-inverse_is_a: HGNC:GABRA1
-inverse_is_a: HGNC:GABRA2
-inverse_is_a: HGNC:GABRA3
-inverse_is_a: HGNC:GABRA4
-inverse_is_a: HGNC:GABRA5
-inverse_is_a: HGNC:GABRA6
-inverse_is_a: HGNC:GABRB1
-inverse_is_a: HGNC:GABRB2
-inverse_is_a: HGNC:GABRB3
-inverse_is_a: HGNC:GABRD
-inverse_is_a: HGNC:GABRE
-inverse_is_a: HGNC:GABRG1
-inverse_is_a: HGNC:GABRG2
-inverse_is_a: HGNC:GABRG3
-inverse_is_a: HGNC:GABRP
-inverse_is_a: HGNC:GABRQ
-inverse_is_a: HGNC:GABRR1
-inverse_is_a: HGNC:GABRR2
-inverse_is_a: HGNC:GABRR3
-
-[Term]
-id: FPLX:GALNT
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4075 ! GABRA1
+relationship: inverse_is_a HGNC:4076 ! GABRA2
+relationship: inverse_is_a HGNC:4077 ! GABRA3
+relationship: inverse_is_a HGNC:4078 ! GABRA4
+relationship: inverse_is_a HGNC:4079 ! GABRA5
+relationship: inverse_is_a HGNC:4080 ! GABRA6
+relationship: inverse_is_a HGNC:4081 ! GABRB1
+relationship: inverse_is_a HGNC:4082 ! GABRB2
+relationship: inverse_is_a HGNC:4083 ! GABRB3
+relationship: inverse_is_a HGNC:4084 ! GABRD
+relationship: inverse_is_a HGNC:4085 ! GABRE
+relationship: inverse_is_a HGNC:4086 ! GABRG1
+relationship: inverse_is_a HGNC:4087 ! GABRG2
+relationship: inverse_is_a HGNC:4088 ! GABRG3
+relationship: inverse_is_a HGNC:4089 ! GABRP
+relationship: inverse_is_a HGNC:14454 ! GABRQ
+relationship: inverse_is_a HGNC:4090 ! GABRR1
+relationship: inverse_is_a HGNC:4091 ! GABRR2
+relationship: inverse_is_a HGNC:17969 ! GABRR3
+
+[Term]
+id: FPLX:000180
 name: GALNT
 synonym: "GALNT" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:GALNTL5
-inverse_is_a: HGNC:GALNTL6
-inverse_is_a: HGNC:GALNT1
-inverse_is_a: HGNC:GALNT2
-inverse_is_a: HGNC:GALNT3
-inverse_is_a: HGNC:GALNT4
-inverse_is_a: HGNC:GALNT5
-inverse_is_a: HGNC:GALNT6
-inverse_is_a: HGNC:GALNT7
-inverse_is_a: HGNC:GALNT8
-inverse_is_a: HGNC:GALNT9
-inverse_is_a: HGNC:GALNT10
-inverse_is_a: HGNC:GALNT11
-inverse_is_a: HGNC:GALNT12
-inverse_is_a: HGNC:GALNT13
-inverse_is_a: HGNC:GALNT14
-inverse_is_a: HGNC:GALNT15
-inverse_is_a: HGNC:GALNT16
-inverse_is_a: HGNC:GALNT18
-inverse_is_a: HGNC:GALNT17
-
-[Term]
-id: FPLX:Gamma_secretase
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:21725 ! GALNTL5
+relationship: inverse_is_a HGNC:33844 ! GALNTL6
+relationship: inverse_is_a HGNC:4123 ! GALNT1
+relationship: inverse_is_a HGNC:4124 ! GALNT2
+relationship: inverse_is_a HGNC:4125 ! GALNT3
+relationship: inverse_is_a HGNC:4126 ! GALNT4
+relationship: inverse_is_a HGNC:4127 ! GALNT5
+relationship: inverse_is_a HGNC:4128 ! GALNT6
+relationship: inverse_is_a HGNC:4129 ! GALNT7
+relationship: inverse_is_a HGNC:4130 ! GALNT8
+relationship: inverse_is_a HGNC:4131 ! GALNT9
+relationship: inverse_is_a HGNC:19873 ! GALNT10
+relationship: inverse_is_a HGNC:19875 ! GALNT11
+relationship: inverse_is_a HGNC:19877 ! GALNT12
+relationship: inverse_is_a HGNC:23242 ! GALNT13
+relationship: inverse_is_a HGNC:22946 ! GALNT14
+relationship: inverse_is_a HGNC:21531 ! GALNT15
+relationship: inverse_is_a HGNC:23233 ! GALNT16
+relationship: inverse_is_a HGNC:30488 ! GALNT18
+relationship: inverse_is_a HGNC:16347 ! GALNT17
+
+[Term]
+id: FPLX:000181
 name: Gamma-secretase
 synonym: "gamma secretase" EXACT []
 synonym: "gamma-secretase" EXACT []
@@ -3019,32 +3039,32 @@ synonym: "γ secretase" EXACT []
 xref: BEL:"gamma Secretase Complex"
 xref: GO:0070765
 xref: NCIT:C95114
-is_a: FPLX:root
-has_part: HGNC:APH1A
-has_part: HGNC:PSEN1
-has_part: HGNC:PSENEN
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:29509 ! APH1A
+relationship: has_part HGNC:9508 ! PSEN1
+relationship: has_part HGNC:30100 ! PSENEN
 
 [Term]
-id: FPLX:GAP
+id: FPLX:000182
 name: GAP
 synonym: "GAP" EXACT []
 synonym: "GTPase-activating proteins" EXACT []
 xref: GO:0005096
 xref: NCIT:C17298
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:GAS6_receptor
+id: FPLX:000183
 name: GAS6-receptor
 synonym: "Gas6 receptors" EXACT []
 xref: BEL:"GAS6 Receptor Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:AXL
-inverse_is_a: HGNC:MERTK
-inverse_is_a: HGNC:TYRO3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:905 ! AXL
+relationship: inverse_is_a HGNC:7027 ! MERTK
+relationship: inverse_is_a HGNC:12446 ! TYRO3
 
 [Term]
-id: FPLX:GATA
+id: FPLX:000184
 name: GATA
 synonym: "GATA family" EXACT []
 synonym: "GATA" EXACT []
@@ -3052,16 +3072,16 @@ xref: BEL:"GATA Family"
 xref: MEDSCAN:urn:agi-aopfc:0000105
 xref: XFAM:PF00320
 xref: RE:R-HSA-996770
-is_a: FPLX:root
-inverse_is_a: HGNC:GATA1
-inverse_is_a: HGNC:GATA2
-inverse_is_a: HGNC:GATA3
-inverse_is_a: HGNC:GATA4
-inverse_is_a: HGNC:GATA5
-inverse_is_a: HGNC:GATA6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4170 ! GATA1
+relationship: inverse_is_a HGNC:4171 ! GATA2
+relationship: inverse_is_a HGNC:4172 ! GATA3
+relationship: inverse_is_a HGNC:4173 ! GATA4
+relationship: inverse_is_a HGNC:15802 ! GATA5
+relationship: inverse_is_a HGNC:4174 ! GATA6
 
 [Term]
-id: FPLX:GCNT
+id: FPLX:000185
 name: GCNT
 synonym: "GCNT" EXACT []
 synonym: "XYLT" EXACT []
@@ -3069,26 +3089,26 @@ synonym: "Xylosyltransferase" EXACT []
 synonym: "Xylosyltransferases" EXACT []
 synonym: "xylosyltransferase" EXACT []
 synonym: "xylosyltransferases" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:GCNT1
-inverse_is_a: HGNC:GCNT2
-inverse_is_a: HGNC:GCNT3
-inverse_is_a: HGNC:GCNT4
-inverse_is_a: HGNC:GCNT7
-inverse_is_a: HGNC:XYLT1
-inverse_is_a: HGNC:XYLT2
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:4203 ! GCNT1
+relationship: inverse_is_a HGNC:4204 ! GCNT2
+relationship: inverse_is_a HGNC:4205 ! GCNT3
+relationship: inverse_is_a HGNC:17973 ! GCNT4
+relationship: inverse_is_a HGNC:16099 ! GCNT7
+relationship: inverse_is_a HGNC:15516 ! XYLT1
+relationship: inverse_is_a HGNC:15517 ! XYLT2
 
 [Term]
-id: FPLX:GEF
+id: FPLX:000186
 name: GEF
 synonym: "GEF" EXACT []
 synonym: "GEFs" EXACT []
 xref: GO:0008433
 xref: NCIT:C17494
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:GPCR
+id: FPLX:000187
 name: GPCR
 synonym: "Class C GPCR" EXACT []
 synonym: "GPCR" EXACT []
@@ -3098,10 +3118,10 @@ xref: MEDSCAN:urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da
 xref: MEDSCAN:urn:agi-protfc:class%20c%20orphan%20receptor
 xref: NCIT:C18239
 xref: SIGNOR:SIGNOR-PF33
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:GPIb_IX_V
+id: FPLX:000188
 name: GPIb-IX-V
 synonym: "glycoprotein Ib-V-IX complex" EXACT []
 synonym: "Glycoprotein Ib-V-IX" EXACT []
@@ -3113,14 +3133,14 @@ xref: BEL:"Ib-V-IX Complex"
 xref: GO:1990779
 xref: NCIT:C126122
 xref: RE:R-HSA-114668
-is_a: FPLX:root
-has_part: HGNC:GP1BA
-has_part: HGNC:GP1BB
-has_part: HGNC:GP5
-has_part: HGNC:GP9
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4439 ! GP1BA
+relationship: has_part HGNC:4440 ! GP1BB
+relationship: has_part HGNC:4443 ! GP5
+relationship: has_part HGNC:4444 ! GP9
 
 [Term]
-id: FPLX:GPIT
+id: FPLX:000189
 name: GPIT
 synonym: "glycosylphosphatidylinositol transamidase complex" EXACT []
 synonym: "GPI transamidase complex" EXACT []
@@ -3128,15 +3148,15 @@ synonym: "GPIT complex" EXACT []
 synonym: "GPIT" EXACT []
 xref: BEL:"GPIT Complex"
 xref: RE:R-HSA-162690
-is_a: FPLX:root
-has_part: HGNC:GPAA1
-has_part: HGNC:PIGK
-has_part: HGNC:PIGS
-has_part: HGNC:PIGT
-has_part: HGNC:PIGU
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4446 ! GPAA1
+relationship: has_part HGNC:8965 ! PIGK
+relationship: has_part HGNC:14937 ! PIGS
+relationship: has_part HGNC:14938 ! PIGT
+relationship: has_part HGNC:15791 ! PIGU
 
 [Term]
-id: FPLX:GPX
+id: FPLX:000190
 name: GPX
 synonym: "glutathione peroxidase" EXACT []
 xref: BEL:"GPX Family"
@@ -3145,18 +3165,18 @@ xref: IP:IPR000889
 xref: IP:IPR029760
 xref: NEXTPROT-FAMILY:01553
 xref: XFAM:PF00255
-is_a: FPLX:root
-inverse_is_a: HGNC:GPX1
-inverse_is_a: HGNC:GPX2
-inverse_is_a: HGNC:GPX3
-inverse_is_a: HGNC:GPX4
-inverse_is_a: HGNC:GPX5
-inverse_is_a: HGNC:GPX6
-inverse_is_a: HGNC:GPX7
-inverse_is_a: HGNC:GPX8
-
-[Term]
-id: FPLX:GRIA
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4553 ! GPX1
+relationship: inverse_is_a HGNC:4554 ! GPX2
+relationship: inverse_is_a HGNC:4555 ! GPX3
+relationship: inverse_is_a HGNC:4556 ! GPX4
+relationship: inverse_is_a HGNC:4557 ! GPX5
+relationship: inverse_is_a HGNC:4558 ! GPX6
+relationship: inverse_is_a HGNC:4559 ! GPX7
+relationship: inverse_is_a HGNC:33100 ! GPX8
+
+[Term]
+id: FPLX:000191
 name: GRIA
 synonym: "AMPA glutamate receptor" EXACT []
 synonym: "AMPA receptor" EXACT []
@@ -3170,14 +3190,14 @@ xref: RE:R-HSA-399713
 xref: RE:R-HSA-416323
 xref: RE:R-HSA-420974
 xref: RE:R-HSA-421001
-is_a: FPLX:root
-inverse_is_a: HGNC:GRIA1
-inverse_is_a: HGNC:GRIA2
-inverse_is_a: HGNC:GRIA3
-inverse_is_a: HGNC:GRIA4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4571 ! GRIA1
+relationship: inverse_is_a HGNC:4572 ! GRIA2
+relationship: inverse_is_a HGNC:4573 ! GRIA3
+relationship: inverse_is_a HGNC:4574 ! GRIA4
 
 [Term]
-id: FPLX:GRK
+id: FPLX:000192
 name: GRK
 synonym: "G protein-coupled receptor kinases" EXACT []
 synonym: "GPCR kinases" EXACT []
@@ -3187,16 +3207,16 @@ xref: BEL:"GRK Family"
 xref: ECCODE:2.7.11.16
 xref: IP:IPR000239
 xref: NCIT:C26233
-is_a: FPLX:root
-inverse_is_a: FPLX:ADRBK
-inverse_is_a: HGNC:GRK1
-inverse_is_a: HGNC:GRK4
-inverse_is_a: HGNC:GRK5
-inverse_is_a: HGNC:GRK6
-inverse_is_a: HGNC:GRK7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000022 ! ADRBK
+relationship: inverse_is_a HGNC:10013 ! GRK1
+relationship: inverse_is_a HGNC:4543 ! GRK4
+relationship: inverse_is_a HGNC:4544 ! GRK5
+relationship: inverse_is_a HGNC:4545 ! GRK6
+relationship: inverse_is_a HGNC:17031 ! GRK7
 
 [Term]
-id: FPLX:GRM
+id: FPLX:000193
 name: GRM
 synonym: "glutamate metabotropic receptors" EXACT []
 synonym: "metabotrophic glutamate receptor" EXACT []
@@ -3207,18 +3227,18 @@ xref: IP:IPR000162
 xref: MEDSCAN:urn:agi-protfc:mglur
 xref: RE:R-HSA-420516
 xref: RE:R-HSA-420519
-is_a: FPLX:root
-inverse_is_a: HGNC:GRM1
-inverse_is_a: HGNC:GRM2
-inverse_is_a: HGNC:GRM3
-inverse_is_a: HGNC:GRM4
-inverse_is_a: HGNC:GRM5
-inverse_is_a: HGNC:GRM6
-inverse_is_a: HGNC:GRM7
-inverse_is_a: HGNC:GRM8
-
-[Term]
-id: FPLX:GSK3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4593 ! GRM1
+relationship: inverse_is_a HGNC:4594 ! GRM2
+relationship: inverse_is_a HGNC:4595 ! GRM3
+relationship: inverse_is_a HGNC:4596 ! GRM4
+relationship: inverse_is_a HGNC:4597 ! GRM5
+relationship: inverse_is_a HGNC:4598 ! GRM6
+relationship: inverse_is_a HGNC:4599 ! GRM7
+relationship: inverse_is_a HGNC:4600 ! GRM8
+
+[Term]
+id: FPLX:000194
 name: GSK3
 synonym: "GSK-3" EXACT []
 synonym: "GSK3" EXACT []
@@ -3227,12 +3247,12 @@ xref: MEDSCAN:urn:agi-aopfc:0000434
 xref: NEXTPROT-FAMILY:03087
 xref: RE:R-HSA-198358
 xref: RE:R-HSA-198373
-is_a: FPLX:root
-inverse_is_a: HGNC:GSK3A
-inverse_is_a: HGNC:GSK3B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4616 ! GSK3A
+relationship: inverse_is_a HGNC:4617 ! GSK3B
 
 [Term]
-id: FPLX:GST
+id: FPLX:000195
 name: GST
 synonym: "glutathione S-transferase" EXACT []
 synonym: "GST" EXACT []
@@ -3240,28 +3260,28 @@ synonym: "GSTs" EXACT []
 xref: BEL:"GST Family"
 xref: NCIT:C16641
 xref: NEXTPROT-FAMILY:01669
-is_a: FPLX:root
-inverse_is_a: HGNC:GSTA1
-inverse_is_a: HGNC:GSTA2
-inverse_is_a: HGNC:GSTA3
-inverse_is_a: HGNC:GSTA4
-inverse_is_a: HGNC:GSTA5
-inverse_is_a: HGNC:GSTK1
-inverse_is_a: HGNC:GSTM1
-inverse_is_a: HGNC:GSTM2
-inverse_is_a: HGNC:GSTM3
-inverse_is_a: HGNC:GSTM4
-inverse_is_a: HGNC:GSTM5
-inverse_is_a: HGNC:GSTO1
-inverse_is_a: HGNC:GSTO2
-inverse_is_a: HGNC:GSTP1
-inverse_is_a: HGNC:GSTT1
-inverse_is_a: HGNC:GSTT2
-inverse_is_a: HGNC:GSTZ1
-inverse_is_a: HGNC:GSTT2B
-
-[Term]
-id: FPLX:GTF2E
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4626 ! GSTA1
+relationship: inverse_is_a HGNC:4627 ! GSTA2
+relationship: inverse_is_a HGNC:4628 ! GSTA3
+relationship: inverse_is_a HGNC:4629 ! GSTA4
+relationship: inverse_is_a HGNC:19662 ! GSTA5
+relationship: inverse_is_a HGNC:16906 ! GSTK1
+relationship: inverse_is_a HGNC:4632 ! GSTM1
+relationship: inverse_is_a HGNC:4634 ! GSTM2
+relationship: inverse_is_a HGNC:4635 ! GSTM3
+relationship: inverse_is_a HGNC:4636 ! GSTM4
+relationship: inverse_is_a HGNC:4637 ! GSTM5
+relationship: inverse_is_a HGNC:13312 ! GSTO1
+relationship: inverse_is_a HGNC:23064 ! GSTO2
+relationship: inverse_is_a HGNC:4638 ! GSTP1
+relationship: inverse_is_a HGNC:4641 ! GSTT1
+relationship: inverse_is_a HGNC:4642 ! GSTT2
+relationship: inverse_is_a HGNC:4643 ! GSTZ1
+relationship: inverse_is_a HGNC:33437 ! GSTT2B
+
+[Term]
+id: FPLX:000196
 name: GTF2E
 synonym: "general transcription factor II E" EXACT []
 synonym: "TFIIE" EXACT []
@@ -3270,12 +3290,12 @@ synonym: "transcription factor IIE" EXACT []
 xref: BEL:"GTF2E Complex"
 xref: GO:0005673
 xref: RE:R-HSA-109633
-is_a: FPLX:root
-has_part: HGNC:GTF2E1
-has_part: HGNC:GTF2E2
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4650 ! GTF2E1
+relationship: has_part HGNC:4651 ! GTF2E2
 
 [Term]
-id: FPLX:GTF2F
+id: FPLX:000197
 name: GTF2F
 synonym: "general transcription factor II F" EXACT []
 synonym: "TFIIF" EXACT []
@@ -3285,84 +3305,84 @@ xref: BEL:"GTF2F Complex"
 xref: GO:0005674
 xref: IP:IPR011039
 xref: RE:R-HSA-109631
-is_a: FPLX:root
-has_part: HGNC:GTF2F1
-has_part: HGNC:GTF2F2
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4652 ! GTF2F1
+relationship: has_part HGNC:4653 ! GTF2F2
 
 [Term]
-id: FPLX:Glycosyltransferase
+id: FPLX:000198
 name: Glycosyltransferase
 xref: MESH:D016695
-is_a: FPLX:root
-inverse_is_a: FPLX:A4GALT_family
-inverse_is_a: FPLX:ALG10
-inverse_is_a: FPLX:ALG1_family
-inverse_is_a: FPLX:ALG3_family
-inverse_is_a: FPLX:ALG6_family
-inverse_is_a: FPLX:ALG13_family
-inverse_is_a: FPLX:B3GAT
-inverse_is_a: FPLX:Beta_3_4_GTF
-inverse_is_a: FPLX:COLGALT
-inverse_is_a: FPLX:EXT
-inverse_is_a: FPLX:FUT
-inverse_is_a: FPLX:GALNT
-inverse_is_a: FPLX:GCNT
-inverse_is_a: FPLX:GTF_family_2
-inverse_is_a: FPLX:GTF_family_6
-inverse_is_a: FPLX:GTF_family_8
-inverse_is_a: FPLX:GTF_family_29
-inverse_is_a: FPLX:GTF_family_90
-inverse_is_a: FPLX:MGAT
-inverse_is_a: FPLX:OGT_family
-inverse_is_a: FPLX:PYG
-inverse_is_a: FPLX:STT3
-inverse_is_a: FPLX:UGCG
-inverse_is_a: FPLX:UGT
-inverse_is_a: FPLX:UGGT
-
-[Term]
-id: FPLX:GTF_family_2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000002 ! A4GALT_family
+relationship: inverse_is_a FPLX:000026 ! ALG10
+relationship: inverse_is_a FPLX:000027 ! ALG1_family
+relationship: inverse_is_a FPLX:000028 ! ALG3_family
+relationship: inverse_is_a FPLX:000029 ! ALG6_family
+relationship: inverse_is_a FPLX:000030 ! ALG13_family
+relationship: inverse_is_a FPLX:000063 ! B3GAT
+relationship: inverse_is_a FPLX:000065 ! Beta_3_4_GTF
+relationship: inverse_is_a FPLX:000112 ! COLGALT
+relationship: inverse_is_a FPLX:000165 ! EXT
+relationship: inverse_is_a FPLX:000176 ! FUT
+relationship: inverse_is_a FPLX:000180 ! GALNT
+relationship: inverse_is_a FPLX:000185 ! GCNT
+relationship: inverse_is_a FPLX:000199 ! GTF_family_2
+relationship: inverse_is_a FPLX:000200 ! GTF_family_6
+relationship: inverse_is_a FPLX:000201 ! GTF_family_8
+relationship: inverse_is_a FPLX:000202 ! GTF_family_29
+relationship: inverse_is_a FPLX:000203 ! GTF_family_90
+relationship: inverse_is_a FPLX:000287 ! MGAT
+relationship: inverse_is_a FPLX:000322 ! OGT_family
+relationship: inverse_is_a FPLX:000396 ! PYG
+relationship: inverse_is_a FPLX:000455 ! STT3
+relationship: inverse_is_a FPLX:000491 ! UGCG
+relationship: inverse_is_a FPLX:000492 ! UGT
+relationship: inverse_is_a FPLX:000493 ! UGGT
+
+[Term]
+id: FPLX:000199
 name: GTF-family-2
 synonym: "Glycosyltransferase family 2" EXACT []
 synonym: "glycosyltransferase family 2" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ALG5
-inverse_is_a: HGNC:B3GNTL1
-inverse_is_a: HGNC:DPM1
-inverse_is_a: HGNC:HAS1
-inverse_is_a: HGNC:HAS2
-inverse_is_a: HGNC:HAS3
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:20266 ! ALG5
+relationship: inverse_is_a HGNC:21727 ! B3GNTL1
+relationship: inverse_is_a HGNC:3005 ! DPM1
+relationship: inverse_is_a HGNC:4818 ! HAS1
+relationship: inverse_is_a HGNC:4819 ! HAS2
+relationship: inverse_is_a HGNC:4820 ! HAS3
 
 [Term]
-id: FPLX:GTF_family_6
+id: FPLX:000200
 name: GTF-family-6
 synonym: "Glycosyltransferase family 6" EXACT []
 synonym: "glycosyltransferase family 6" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ABO
-inverse_is_a: HGNC:A3GALT2
-inverse_is_a: HGNC:GBGT1
-inverse_is_a: HGNC:GLT6D1
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:79 ! ABO
+relationship: inverse_is_a HGNC:30005 ! A3GALT2
+relationship: inverse_is_a HGNC:20460 ! GBGT1
+relationship: inverse_is_a HGNC:23671 ! GLT6D1
 
 [Term]
-id: FPLX:GTF_family_8
+id: FPLX:000201
 name: GTF-family-8
 synonym: "Glycosyltransferase family 8" EXACT []
 synonym: "glycosyltransferase family 8" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:GLT8D1
-inverse_is_a: HGNC:GLT8D2
-inverse_is_a: HGNC:GXYLT1
-inverse_is_a: HGNC:GXYLT2
-inverse_is_a: HGNC:GYG1
-inverse_is_a: HGNC:GYG2
-inverse_is_a: HGNC:LARGE1
-inverse_is_a: HGNC:LARGE2
-inverse_is_a: HGNC:RXYLT1
-inverse_is_a: HGNC:XXYLT1
-
-[Term]
-id: FPLX:GTF_family_29
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:24870 ! GLT8D1
+relationship: inverse_is_a HGNC:24890 ! GLT8D2
+relationship: inverse_is_a HGNC:27482 ! GXYLT1
+relationship: inverse_is_a HGNC:33383 ! GXYLT2
+relationship: inverse_is_a HGNC:4699 ! GYG1
+relationship: inverse_is_a HGNC:4700 ! GYG2
+relationship: inverse_is_a HGNC:6511 ! LARGE1
+relationship: inverse_is_a HGNC:16522 ! LARGE2
+relationship: inverse_is_a HGNC:13530 ! RXYLT1
+relationship: inverse_is_a HGNC:26639 ! XXYLT1
+
+[Term]
+id: FPLX:000202
 name: GTF-family-29
 synonym: "Glycosyltransferase family 29" EXACT []
 synonym: "glycosyltransferase family 29" EXACT []
@@ -3370,74 +3390,74 @@ synonym: "Sialytransferase" EXACT []
 synonym: "Sialytransferases" EXACT []
 synonym: "sialytransferase" EXACT []
 synonym: "sialytransferases" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:ST3GAL1
-inverse_is_a: HGNC:ST3GAL2
-inverse_is_a: HGNC:ST3GAL3
-inverse_is_a: HGNC:ST3GAL4
-inverse_is_a: HGNC:ST3GAL5
-inverse_is_a: HGNC:ST3GAL6
-inverse_is_a: HGNC:ST6GALNAC1
-inverse_is_a: HGNC:ST6GALNAC2
-inverse_is_a: HGNC:ST6GALNAC3
-inverse_is_a: HGNC:ST6GALNAC4
-inverse_is_a: HGNC:ST6GALNAC5
-inverse_is_a: HGNC:ST6GALNAC6
-inverse_is_a: HGNC:ST6GAL1
-inverse_is_a: HGNC:ST6GAL2
-inverse_is_a: HGNC:ST8SIA1
-inverse_is_a: HGNC:ST8SIA2
-inverse_is_a: HGNC:ST8SIA3
-inverse_is_a: HGNC:ST8SIA4
-inverse_is_a: HGNC:ST8SIA5
-inverse_is_a: HGNC:ST8SIA6
-
-[Term]
-id: FPLX:GTF_family_90
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:10862 ! ST3GAL1
+relationship: inverse_is_a HGNC:10863 ! ST3GAL2
+relationship: inverse_is_a HGNC:10866 ! ST3GAL3
+relationship: inverse_is_a HGNC:10864 ! ST3GAL4
+relationship: inverse_is_a HGNC:10872 ! ST3GAL5
+relationship: inverse_is_a HGNC:18080 ! ST3GAL6
+relationship: inverse_is_a HGNC:23614 ! ST6GALNAC1
+relationship: inverse_is_a HGNC:10867 ! ST6GALNAC2
+relationship: inverse_is_a HGNC:19343 ! ST6GALNAC3
+relationship: inverse_is_a HGNC:17846 ! ST6GALNAC4
+relationship: inverse_is_a HGNC:19342 ! ST6GALNAC5
+relationship: inverse_is_a HGNC:23364 ! ST6GALNAC6
+relationship: inverse_is_a HGNC:10860 ! ST6GAL1
+relationship: inverse_is_a HGNC:10861 ! ST6GAL2
+relationship: inverse_is_a HGNC:10869 ! ST8SIA1
+relationship: inverse_is_a HGNC:10870 ! ST8SIA2
+relationship: inverse_is_a HGNC:14269 ! ST8SIA3
+relationship: inverse_is_a HGNC:10871 ! ST8SIA4
+relationship: inverse_is_a HGNC:17827 ! ST8SIA5
+relationship: inverse_is_a HGNC:23317 ! ST8SIA6
+
+[Term]
+id: FPLX:000203
 name: GTF-family-90
 synonym: "Glycosyltransferase family 90" EXACT []
 synonym: "glycosyltransferase family 90" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:POGLUT2
-inverse_is_a: HGNC:POGLUT3
-inverse_is_a: HGNC:POGLUT1
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:19350 ! POGLUT2
+relationship: inverse_is_a HGNC:28496 ! POGLUT3
+relationship: inverse_is_a HGNC:22954 ! POGLUT1
 
 [Term]
-id: FPLX:GTPase
+id: FPLX:000204
 name: GTPase
 synonym: "GTPase" EXACT []
 xref: ECCODE:3.6.5.-
 xref: MEDSCAN:urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196
 xref: NCIT:C16650
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:GUCY
+id: FPLX:000205
 name: GUCY
 synonym: "guanylate cyclase" EXACT []
 synonym: "guanylyl cyclase" EXACT []
 xref: BEL:"GUCY Family"
 xref: ECCODE:4.6.1.2
 xref: NCIT:C16653
-is_a: FPLX:root
-inverse_is_a: HGNC:GUCY2C
-inverse_is_a: HGNC:GUCY2D
-inverse_is_a: HGNC:GUCY2F
-inverse_is_a: HGNC:NPR1
-inverse_is_a: HGNC:NPR2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4688 ! GUCY2C
+relationship: inverse_is_a HGNC:4689 ! GUCY2D
+relationship: inverse_is_a HGNC:4691 ! GUCY2F
+relationship: inverse_is_a HGNC:7943 ! NPR1
+relationship: inverse_is_a HGNC:7944 ! NPR2
 
 [Term]
-id: FPLX:GYS
+id: FPLX:000206
 name: GYS
 synonym: "glycogen synthase" EXACT []
 xref: BEL:"GYS Family"
 xref: IP:IPR008631
-is_a: FPLX:root
-inverse_is_a: HGNC:GYS1
-inverse_is_a: HGNC:GYS2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4706 ! GYS1
+relationship: inverse_is_a HGNC:4707 ! GYS2
 
 [Term]
-id: FPLX:G_12
+id: FPLX:000207
 name: G-12
 synonym: "G(12)" EXACT []
 synonym: "G12 family" EXACT []
@@ -3447,11 +3467,11 @@ xref: IP:IPR000469
 xref: RE:R-HSA-114547
 xref: RE:R-HSA-418570
 xref: RE:R-HSA-418572
-is_a: FPLX:G_protein
-has_part: FPLX:G_12_alpha
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000208 ! G_12_alpha
 
 [Term]
-id: FPLX:G_12_alpha
+id: FPLX:000208
 name: G-12-alpha
 synonym: "G-protein alpha-12" EXACT []
 synonym: "G-protein α-12" EXACT []
@@ -3462,25 +3482,25 @@ xref: IP:IPR000469
 xref: RE:R-HSA-114525
 xref: RE:R-HSA-418570
 xref: RE:R-HSA-418572
-is_a: FPLX:G_alpha
-part_of: FPLX:G_12
-inverse_is_a: HGNC:GNA12
-inverse_is_a: HGNC:GNA13
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000207 ! G_12
+relationship: inverse_is_a HGNC:4380 ! GNA12
+relationship: inverse_is_a HGNC:4381 ! GNA13
 
 [Term]
-id: FPLX:G_alpha
+id: FPLX:000209
 name: G-alpha
 synonym: "G_alpha" EXACT []
 synonym: "G_α" EXACT []
 xref: XFAM:PF00503
-is_a: FPLX:root
-inverse_is_a: FPLX:G_i_alpha
-inverse_is_a: FPLX:G_s_alpha
-inverse_is_a: FPLX:G_q_alpha
-inverse_is_a: FPLX:G_12_alpha
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000213 ! G_i_alpha
+relationship: inverse_is_a FPLX:000218 ! G_s_alpha
+relationship: inverse_is_a FPLX:000216 ! G_q_alpha
+relationship: inverse_is_a FPLX:000208 ! G_12_alpha
 
 [Term]
-id: FPLX:G_beta
+id: FPLX:000210
 name: G-beta
 synonym: "G protein beta" EXACT []
 synonym: "G protein β" EXACT []
@@ -3496,15 +3516,15 @@ xref: RE:R-HSA-6814207
 xref: RE:R-HSA-6814413
 xref: RE:R-HSA-8850524
 xref: SIGNOR:SIGNOR-PF4
-is_a: FPLX:root
-inverse_is_a: HGNC:GNB1
-inverse_is_a: HGNC:GNB2
-inverse_is_a: HGNC:GNB3
-inverse_is_a: HGNC:GNB4
-inverse_is_a: HGNC:GNB5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4396 ! GNB1
+relationship: inverse_is_a HGNC:4398 ! GNB2
+relationship: inverse_is_a HGNC:4400 ! GNB3
+relationship: inverse_is_a HGNC:20731 ! GNB4
+relationship: inverse_is_a HGNC:4401 ! GNB5
 
 [Term]
-id: FPLX:G_gamma
+id: FPLX:000211
 name: G-gamma
 synonym: "G protein gamma subunit" EXACT []
 synonym: "G protein gamma" EXACT []
@@ -3516,22 +3536,22 @@ xref: NEXTPROT-FAMILY:01400
 xref: RE:R-HSA-167442
 xref: RE:R-HSA-400062
 xref: SIGNOR:SIGNOR-PF3
-is_a: FPLX:root
-inverse_is_a: HGNC:GNG10
-inverse_is_a: HGNC:GNG11
-inverse_is_a: HGNC:GNG12
-inverse_is_a: HGNC:GNG13
-inverse_is_a: HGNC:GNG2
-inverse_is_a: HGNC:GNG3
-inverse_is_a: HGNC:GNG4
-inverse_is_a: HGNC:GNG5
-inverse_is_a: HGNC:GNG7
-inverse_is_a: HGNC:GNG8
-inverse_is_a: HGNC:GNGT1
-inverse_is_a: HGNC:GNGT2
-
-[Term]
-id: FPLX:G_i
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4402 ! GNG10
+relationship: inverse_is_a HGNC:4403 ! GNG11
+relationship: inverse_is_a HGNC:19663 ! GNG12
+relationship: inverse_is_a HGNC:14131 ! GNG13
+relationship: inverse_is_a HGNC:4404 ! GNG2
+relationship: inverse_is_a HGNC:4405 ! GNG3
+relationship: inverse_is_a HGNC:4407 ! GNG4
+relationship: inverse_is_a HGNC:4408 ! GNG5
+relationship: inverse_is_a HGNC:4410 ! GNG7
+relationship: inverse_is_a HGNC:19664 ! GNG8
+relationship: inverse_is_a HGNC:4411 ! GNGT1
+relationship: inverse_is_a HGNC:4412 ! GNGT2
+
+[Term]
+id: FPLX:000212
 name: G-i
 synonym: "Gi protein" EXACT []
 synonym: "Gi" EXACT []
@@ -3541,11 +3561,11 @@ xref: RE:R-HSA-111864
 xref: RE:R-HSA-167410
 xref: RE:R-HSA-167413
 xref: RE:R-HSA-167438
-is_a: FPLX:G_protein
-has_part: FPLX:G_i_alpha
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000213 ! G_i_alpha
 
 [Term]
-id: FPLX:G_i_alpha
+id: FPLX:000213
 name: G-i-alpha
 synonym: "G alphai" EXACT []
 synonym: "G αi" EXACT []
@@ -3563,31 +3583,31 @@ xref: RE:R-HSA-111864
 xref: RE:R-HSA-167410
 xref: RE:R-HSA-167413
 xref: RE:R-HSA-167438
-is_a: FPLX:G_alpha
-part_of: FPLX:G_i
-inverse_is_a: HGNC:GNAO1
-inverse_is_a: HGNC:GNAI1
-inverse_is_a: HGNC:GNAI2
-inverse_is_a: HGNC:GNAI3
-inverse_is_a: HGNC:GNAT1
-inverse_is_a: HGNC:GNAT2
-inverse_is_a: HGNC:GNAT3
-inverse_is_a: HGNC:GNAZ
-
-[Term]
-id: FPLX:G_protein
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000212 ! G_i
+relationship: inverse_is_a HGNC:4389 ! GNAO1
+relationship: inverse_is_a HGNC:4384 ! GNAI1
+relationship: inverse_is_a HGNC:4385 ! GNAI2
+relationship: inverse_is_a HGNC:4387 ! GNAI3
+relationship: inverse_is_a HGNC:4393 ! GNAT1
+relationship: inverse_is_a HGNC:4394 ! GNAT2
+relationship: inverse_is_a HGNC:22800 ! GNAT3
+relationship: inverse_is_a HGNC:4395 ! GNAZ
+
+[Term]
+id: FPLX:000214
 name: G-protein
 synonym: "G protein" EXACT []
 synonym: "G proteins" EXACT []
 xref: NCIT:C17458
-is_a: FPLX:root
-inverse_is_a: FPLX:G_i
-inverse_is_a: FPLX:G_s
-inverse_is_a: FPLX:G_q
-inverse_is_a: FPLX:G_12
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000212 ! G_i
+relationship: inverse_is_a FPLX:000217 ! G_s
+relationship: inverse_is_a FPLX:000215 ! G_q
+relationship: inverse_is_a FPLX:000207 ! G_12
 
 [Term]
-id: FPLX:G_q
+id: FPLX:000215
 name: G-q
 synonym: "G(q/11)" EXACT []
 synonym: "Gq/11" EXACT []
@@ -3601,11 +3621,11 @@ xref: RE:R-HSA-399992
 xref: RE:R-HSA-400000
 xref: RE:R-HSA-400008
 xref: RE:R-HSA-749499
-is_a: FPLX:G_protein
-has_part: FPLX:G_q_alpha
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000216 ! G_q_alpha
 
 [Term]
-id: FPLX:G_q_alpha
+id: FPLX:000216
 name: G-q-alpha
 synonym: "G alphaq" EXACT []
 synonym: "G αq" EXACT []
@@ -3626,15 +3646,15 @@ xref: RE:R-HSA-399992
 xref: RE:R-HSA-400000
 xref: RE:R-HSA-400008
 xref: RE:R-HSA-749499
-is_a: FPLX:G_alpha
-part_of: FPLX:G_q
-inverse_is_a: HGNC:GNAQ
-inverse_is_a: HGNC:GNA11
-inverse_is_a: HGNC:GNA14
-inverse_is_a: HGNC:GNA15
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000215 ! G_q
+relationship: inverse_is_a HGNC:4390 ! GNAQ
+relationship: inverse_is_a HGNC:4379 ! GNA11
+relationship: inverse_is_a HGNC:4382 ! GNA14
+relationship: inverse_is_a HGNC:4383 ! GNA15
 
 [Term]
-id: FPLX:G_s
+id: FPLX:000217
 name: G-s
 synonym: "G protein Gs" EXACT []
 synonym: "G protein(s)" EXACT []
@@ -3642,11 +3662,11 @@ synonym: "G S protein" EXACT []
 synonym: "Gs family" EXACT []
 synonym: "Gs protein" EXACT []
 xref: BEL:"GNA Gs Family"
-is_a: FPLX:G_protein
-has_part: FPLX:G_s_alpha
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000218 ! G_s_alpha
 
 [Term]
-id: FPLX:G_s_alpha
+id: FPLX:000218
 name: G-s-alpha
 synonym: "G alphaS" EXACT []
 synonym: "G αS" EXACT []
@@ -3662,23 +3682,23 @@ synonym: "Gs alpha" EXACT []
 synonym: "Gs α subunit" EXACT []
 synonym: "Gs α" EXACT []
 synonym: "GαS" EXACT []
-is_a: FPLX:G_alpha
-part_of: FPLX:G_s
-inverse_is_a: HGNC:GNAS
-inverse_is_a: HGNC:GNAL
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000217 ! G_s
+relationship: inverse_is_a HGNC:4392 ! GNAS
+relationship: inverse_is_a HGNC:4388 ! GNAL
 
 [Term]
-id: FPLX:hCG
+id: FPLX:000219
 name: hCG
 synonym: "hCG" EXACT []
 xref: NCIT:C2275
 xref: RE:R-HSA-378941
-is_a: FPLX:root
-has_part: HGNC:CGA
-has_part: HGNC:CGB3
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1885 ! CGA
+relationship: has_part HGNC:1886 ! CGB3
 
 [Term]
-id: FPLX:HDAC
+id: FPLX:000220
 name: HDAC
 synonym: "HDAC" EXACT []
 synonym: "histone deacetylase" EXACT []
@@ -3688,83 +3708,83 @@ xref: ECCODE:3.5.1.98
 xref: IP:IPR003084
 xref: MEDSCAN:urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b
 xref: NCIT:C16682
-is_a: FPLX:root
-inverse_is_a: FPLX:HDAC_I
-inverse_is_a: FPLX:HDAC_II
-inverse_is_a: FPLX:HDAC_III
-inverse_is_a: FPLX:HDAC_IV
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000221 ! HDAC_I
+relationship: inverse_is_a FPLX:000222 ! HDAC_II
+relationship: inverse_is_a FPLX:000223 ! HDAC_III
+relationship: inverse_is_a FPLX:000224 ! HDAC_IV
 
 [Term]
-id: FPLX:HDAC_I
+id: FPLX:000221
 name: HDAC-I
 synonym: "Class I HDACs" EXACT []
 synonym: "class I HDACs" EXACT []
 synonym: "class I histone deacetylases" EXACT []
 xref: BEL:"HDAC Class I Family"
 xref: IP:IPR003084
-is_a: FPLX:HDAC
-inverse_is_a: HGNC:HDAC1
-inverse_is_a: HGNC:HDAC2
-inverse_is_a: HGNC:HDAC3
-inverse_is_a: HGNC:HDAC8
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:4852 ! HDAC1
+relationship: inverse_is_a HGNC:4853 ! HDAC2
+relationship: inverse_is_a HGNC:4854 ! HDAC3
+relationship: inverse_is_a HGNC:13315 ! HDAC8
 
 [Term]
-id: FPLX:HDAC_II
+id: FPLX:000222
 name: HDAC-II
 synonym: "class II HDACs" EXACT []
 synonym: "class II histone deacetylases" EXACT []
 xref: BEL:"HDAC Class II Family"
-is_a: FPLX:HDAC
-inverse_is_a: HGNC:HDAC4
-inverse_is_a: HGNC:HDAC5
-inverse_is_a: HGNC:HDAC7
-inverse_is_a: HGNC:HDAC9
-inverse_is_a: HGNC:HDAC6
-inverse_is_a: HGNC:HDAC10
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:14063 ! HDAC4
+relationship: inverse_is_a HGNC:14068 ! HDAC5
+relationship: inverse_is_a HGNC:14067 ! HDAC7
+relationship: inverse_is_a HGNC:14065 ! HDAC9
+relationship: inverse_is_a HGNC:14064 ! HDAC6
+relationship: inverse_is_a HGNC:18128 ! HDAC10
 
 [Term]
-id: FPLX:HDAC_III
+id: FPLX:000223
 name: HDAC-III
 synonym: "Class III HDACs" EXACT []
 synonym: "class III HDACs" EXACT []
 synonym: "class III histone deacetylases" EXACT []
 xref: IP:IPR003000
 xref: IP:IPR026590
-is_a: FPLX:HDAC
-inverse_is_a: HGNC:SIRT1
-inverse_is_a: HGNC:SIRT2
-inverse_is_a: HGNC:SIRT3
-inverse_is_a: HGNC:SIRT4
-inverse_is_a: HGNC:SIRT5
-inverse_is_a: HGNC:SIRT6
-inverse_is_a: HGNC:SIRT7
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:14929 ! SIRT1
+relationship: inverse_is_a HGNC:10886 ! SIRT2
+relationship: inverse_is_a HGNC:14931 ! SIRT3
+relationship: inverse_is_a HGNC:14932 ! SIRT4
+relationship: inverse_is_a HGNC:14933 ! SIRT5
+relationship: inverse_is_a HGNC:14934 ! SIRT6
+relationship: inverse_is_a HGNC:14935 ! SIRT7
 
 [Term]
-id: FPLX:HDAC_IV
+id: FPLX:000224
 name: HDAC-IV
 synonym: "Class IV HDACs" EXACT []
 synonym: "class IV HDACs" EXACT []
 synonym: "class IV histone deacetylases" EXACT []
-is_a: FPLX:HDAC
-inverse_is_a: HGNC:HDAC11
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:19086 ! HDAC11
 
 [Term]
-id: FPLX:HDL
+id: FPLX:000225
 name: HDL
 synonym: "HDL" EXACT []
 synonym: "High-density lipoproteins" EXACT []
 xref: BEL:"HDL Complex"
 xref: GO:0034364
 xref: NCIT:C25186
-is_a: FPLX:root
-has_part: HGNC:ALB
-has_part: HGNC:APOA1
-has_part: HGNC:APOA2
-has_part: HGNC:APOE
-has_part: HGNC:CLU
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:399 ! ALB
+relationship: has_part HGNC:600 ! APOA1
+relationship: has_part HGNC:601 ! APOA2
+relationship: has_part HGNC:613 ! APOE
+relationship: has_part HGNC:2095 ! CLU
 
 [Term]
-id: FPLX:Hedgehog
+id: FPLX:000226
 name: Hedgehog
 synonym: "Hedgehog family" EXACT []
 synonym: "hedgehog protein" EXACT []
@@ -3787,99 +3807,99 @@ xref: RE:R-HSA-5358318
 xref: RE:R-HSA-5358332
 xref: RE:R-HSA-5362382
 xref: RE:R-HSA-5362391
-is_a: FPLX:root
-inverse_is_a: HGNC:DHH
-inverse_is_a: HGNC:IHH
-inverse_is_a: HGNC:SHH
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2865 ! DHH
+relationship: inverse_is_a HGNC:5956 ! IHH
+relationship: inverse_is_a HGNC:10848 ! SHH
 
 [Term]
-id: FPLX:Hemoglobin
+id: FPLX:000227
 name: Hemoglobin
 synonym: "hemoglobin" EXACT []
 xref: BEL:"Hemoglobin Complex"
 xref: MEDSCAN:urn:agi-protfc:hemoglobin
 xref: NCIT:C16676
-is_a: FPLX:root
-has_part: HGNC:HBA1
-has_part: HGNC:HBA2
-has_part: HGNC:HBB
-has_part: HGNC:HBD
-has_part: HGNC:HBE1
-has_part: HGNC:HBG1
-has_part: HGNC:HBG2
-has_part: HGNC:HBM
-has_part: HGNC:HBQ1
-has_part: HGNC:HBZ
-
-[Term]
-id: FPLX:HES
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4823 ! HBA1
+relationship: has_part HGNC:4824 ! HBA2
+relationship: has_part HGNC:4827 ! HBB
+relationship: has_part HGNC:4829 ! HBD
+relationship: has_part HGNC:4830 ! HBE1
+relationship: has_part HGNC:4831 ! HBG1
+relationship: has_part HGNC:4832 ! HBG2
+relationship: has_part HGNC:4826 ! HBM
+relationship: has_part HGNC:4833 ! HBQ1
+relationship: has_part HGNC:4835 ! HBZ
+
+[Term]
+id: FPLX:000228
 name: HES
 synonym: "Hes gene family" EXACT []
 synonym: "Hes genes" EXACT []
 synonym: "HES" EXACT []
 synonym: "Hes" EXACT []
 xref: BEL:"HES Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:HES1
-inverse_is_a: HGNC:HES2
-inverse_is_a: HGNC:HES3
-inverse_is_a: HGNC:HES4
-inverse_is_a: HGNC:HES5
-inverse_is_a: HGNC:HES6
-inverse_is_a: HGNC:HES7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5192 ! HES1
+relationship: inverse_is_a HGNC:16005 ! HES2
+relationship: inverse_is_a HGNC:26226 ! HES3
+relationship: inverse_is_a HGNC:24149 ! HES4
+relationship: inverse_is_a HGNC:19764 ! HES5
+relationship: inverse_is_a HGNC:18254 ! HES6
+relationship: inverse_is_a HGNC:15977 ! HES7
 
 [Term]
-id: FPLX:HIF
+id: FPLX:000229
 name: HIF
 synonym: "HIF" EXACT []
 synonym: "HIFs" EXACT []
 synonym: "hypoxia-inducible factors" EXACT []
 xref: NCIT:C113839
 xref: RE:R-HSA-1234130
-is_a: FPLX:root
-has_part: FPLX:HIF_alpha
-has_part: FPLX:HIF_beta
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000231 ! HIF_alpha
+relationship: has_part FPLX:000232 ! HIF_beta
 
 [Term]
-id: FPLX:HIF1
+id: FPLX:000230
 name: HIF1
 synonym: "HIF-1" EXACT []
 xref: MEDSCAN:urn:agi-complex:HIF-1
 xref: MEDSCAN:urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85
 xref: NCIT:C17690
 xref: XFAM:PF11413
-is_a: FPLX:root
-has_part: HGNC:HIF1A
-has_part: HGNC:ARNT
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4910 ! HIF1A
+relationship: has_part HGNC:700 ! ARNT
 
 [Term]
-id: FPLX:HIF_alpha
+id: FPLX:000231
 name: HIF-alpha
 synonym: "HIFalpha" EXACT []
 synonym: "Hifalpha" EXACT []
 synonym: "HIFα" EXACT []
 synonym: "Hifα" EXACT []
 xref: RE:R-HSA-1234147
-part_of: FPLX:HIF
-inverse_is_a: HGNC:HIF1A
-inverse_is_a: HGNC:EPAS1
-inverse_is_a: HGNC:HIF3A
+relationship: part_of FPLX:000229 ! HIF
+relationship: inverse_is_a HGNC:4910 ! HIF1A
+relationship: inverse_is_a HGNC:3374 ! EPAS1
+relationship: inverse_is_a HGNC:15825 ! HIF3A
 
 [Term]
-id: FPLX:HIF_beta
+id: FPLX:000232
 name: HIF-beta
 synonym: "HIFbeta" EXACT []
 synonym: "Hifbeta" EXACT []
 synonym: "HIFβ" EXACT []
 synonym: "Hifβ" EXACT []
 xref: RE:R-HSA-8936837
-part_of: FPLX:HIF
-inverse_is_a: HGNC:ARNT
-inverse_is_a: HGNC:ARNT2
-inverse_is_a: HGNC:ARNTL
+relationship: part_of FPLX:000229 ! HIF
+relationship: inverse_is_a HGNC:700 ! ARNT
+relationship: inverse_is_a HGNC:16876 ! ARNT2
+relationship: inverse_is_a HGNC:701 ! ARNTL
 
 [Term]
-id: FPLX:Histone
+id: FPLX:000233
 name: Histone
 synonym: "Histone" EXACT []
 synonym: "histone" EXACT []
@@ -3889,34 +3909,34 @@ xref: MEDSCAN:urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121
 xref: MEDSCAN:urn:agi-protfc:histone
 xref: MESH:D006657
 xref: NCIT:C16687
-is_a: FPLX:root
-inverse_is_a: FPLX:Histone_H1
-inverse_is_a: FPLX:Histone_H2A
-inverse_is_a: FPLX:Histone_H2B
-inverse_is_a: FPLX:Histone_H3
-inverse_is_a: FPLX:Histone_H4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000234 ! Histone_H1
+relationship: inverse_is_a FPLX:000235 ! Histone_H2A
+relationship: inverse_is_a FPLX:000236 ! Histone_H2B
+relationship: inverse_is_a FPLX:000237 ! Histone_H3
+relationship: inverse_is_a FPLX:000238 ! Histone_H4
 
 [Term]
-id: FPLX:Histone_H1
+id: FPLX:000234
 name: Histone-H1
 synonym: "histone H1" EXACT []
 xref: BEL:"Histone H1 Family"
 xref: MEDSCAN:urn:agi-protfc:histone%20H1
 xref: NCIT:C16683
-is_a: FPLX:Histone
-inverse_is_a: HGNC:H1F0
-inverse_is_a: HGNC:H1FOO
-inverse_is_a: HGNC:H1FX
-inverse_is_a: HGNC:HIST1H1A
-inverse_is_a: HGNC:HIST1H1B
-inverse_is_a: HGNC:HIST1H1C
-inverse_is_a: HGNC:HIST1H1D
-inverse_is_a: HGNC:HIST1H1E
-inverse_is_a: HGNC:HIST1H1T
-inverse_is_a: HGNC:H1FNT
-
-[Term]
-id: FPLX:Histone_H2A
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a HGNC:4714 ! H1F0
+relationship: inverse_is_a HGNC:18463 ! H1FOO
+relationship: inverse_is_a HGNC:4722 ! H1FX
+relationship: inverse_is_a HGNC:4715 ! HIST1H1A
+relationship: inverse_is_a HGNC:4719 ! HIST1H1B
+relationship: inverse_is_a HGNC:4716 ! HIST1H1C
+relationship: inverse_is_a HGNC:4717 ! HIST1H1D
+relationship: inverse_is_a HGNC:4718 ! HIST1H1E
+relationship: inverse_is_a HGNC:4720 ! HIST1H1T
+relationship: inverse_is_a HGNC:24893 ! H1FNT
+
+[Term]
+id: FPLX:000235
 name: Histone-H2A
 synonym: "Histone 2A" EXACT []
 synonym: "Histone H2A" EXACT []
@@ -3925,57 +3945,57 @@ xref: BEL:"Histone H2A Family"
 xref: MEDSCAN:urn:agi-protfc:histone%20H2A
 xref: NCIT:C16684
 xref: NEXTPROT-FAMILY:01762
-is_a: FPLX:Histone
-inverse_is_a: UP:P0C0S8
-inverse_is_a: HGNC:H2AFB1
-inverse_is_a: UP:P0C5Y9
-inverse_is_a: HGNC:H2AFJ
-inverse_is_a: HGNC:H2AFV
-inverse_is_a: HGNC:H2AFX
-inverse_is_a: HGNC:H2AFY
-inverse_is_a: HGNC:H2AFY2
-inverse_is_a: HGNC:H2AFZ
-inverse_is_a: HGNC:HIST1H2AA
-inverse_is_a: HGNC:HIST1H2AC
-inverse_is_a: HGNC:HIST1H2AD
-inverse_is_a: HGNC:HIST1H2AH
-inverse_is_a: HGNC:HIST1H2AJ
-inverse_is_a: HGNC:HIST2H2AB
-inverse_is_a: HGNC:HIST2H2AC
-inverse_is_a: HGNC:HIST3H2A
-inverse_is_a: UP:P04908
-inverse_is_a: UP:Q6FI13
-
-[Term]
-id: FPLX:Histone_H2B
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:P0C0S8 ! H2A1_HUMAN
+relationship: inverse_is_a HGNC:22516 ! H2AFB1
+relationship: inverse_is_a UP:P0C5Y9 ! H2AB1_HUMAN
+relationship: inverse_is_a HGNC:14456 ! H2AFJ
+relationship: inverse_is_a HGNC:20664 ! H2AFV
+relationship: inverse_is_a HGNC:4739 ! H2AFX
+relationship: inverse_is_a HGNC:4740 ! H2AFY
+relationship: inverse_is_a HGNC:14453 ! H2AFY2
+relationship: inverse_is_a HGNC:4741 ! H2AFZ
+relationship: inverse_is_a HGNC:18729 ! HIST1H2AA
+relationship: inverse_is_a HGNC:4733 ! HIST1H2AC
+relationship: inverse_is_a HGNC:4729 ! HIST1H2AD
+relationship: inverse_is_a HGNC:13671 ! HIST1H2AH
+relationship: inverse_is_a HGNC:4727 ! HIST1H2AJ
+relationship: inverse_is_a HGNC:20508 ! HIST2H2AB
+relationship: inverse_is_a HGNC:4738 ! HIST2H2AC
+relationship: inverse_is_a HGNC:20507 ! HIST3H2A
+relationship: inverse_is_a UP:P04908 ! H2A1B_HUMAN
+relationship: inverse_is_a UP:Q6FI13 ! H2A2A_HUMAN
+
+[Term]
+id: FPLX:000236
 name: Histone-H2B
 synonym: "H2B" EXACT []
 synonym: "histone H2B" EXACT []
 xref: BEL:"Histone H2B Family"
 xref: MEDSCAN:urn:agi-protfc:histone%20H2B
-is_a: FPLX:Histone
-inverse_is_a: UP:P62807
-inverse_is_a: HGNC:HIST1H2BA
-inverse_is_a: HGNC:HIST1H2BB
-inverse_is_a: HGNC:HIST1H2BD
-inverse_is_a: HGNC:HIST1H2BH
-inverse_is_a: HGNC:HIST1H2BJ
-inverse_is_a: HGNC:HIST1H2BK
-inverse_is_a: HGNC:HIST1H2BL
-inverse_is_a: HGNC:HIST1H2BM
-inverse_is_a: HGNC:HIST1H2BN
-inverse_is_a: HGNC:HIST1H2BO
-inverse_is_a: HGNC:HIST2H2BC
-inverse_is_a: HGNC:HIST2H2BD
-inverse_is_a: HGNC:HIST2H2BE
-inverse_is_a: HGNC:HIST2H2BF
-inverse_is_a: HGNC:HIST3H2BB
-inverse_is_a: HGNC:H2BFS
-inverse_is_a: HGNC:H2BFM
-inverse_is_a: HGNC:H2BFWT
-
-[Term]
-id: FPLX:Histone_H3
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:P62807 ! H2B1C_HUMAN
+relationship: inverse_is_a HGNC:18730 ! HIST1H2BA
+relationship: inverse_is_a HGNC:4751 ! HIST1H2BB
+relationship: inverse_is_a HGNC:4747 ! HIST1H2BD
+relationship: inverse_is_a HGNC:4755 ! HIST1H2BH
+relationship: inverse_is_a HGNC:4761 ! HIST1H2BJ
+relationship: inverse_is_a HGNC:13954 ! HIST1H2BK
+relationship: inverse_is_a HGNC:4748 ! HIST1H2BL
+relationship: inverse_is_a HGNC:4750 ! HIST1H2BM
+relationship: inverse_is_a HGNC:4749 ! HIST1H2BN
+relationship: inverse_is_a HGNC:4758 ! HIST1H2BO
+relationship: inverse_is_a HGNC:20516 ! HIST2H2BC
+relationship: inverse_is_a HGNC:20517 ! HIST2H2BD
+relationship: inverse_is_a HGNC:4760 ! HIST2H2BE
+relationship: inverse_is_a HGNC:24700 ! HIST2H2BF
+relationship: inverse_is_a HGNC:20514 ! HIST3H2BB
+relationship: inverse_is_a HGNC:4762 ! H2BFS
+relationship: inverse_is_a HGNC:27867 ! H2BFM
+relationship: inverse_is_a HGNC:27252 ! H2BFWT
+
+[Term]
+id: FPLX:000237
 name: Histone-H3
 synonym: "H3" EXACT []
 synonym: "histone H3" EXACT []
@@ -3985,15 +4005,15 @@ xref: IP:IPR000164
 xref: MEDSCAN:urn:agi-protfc:histone%20H3
 xref: NCIT:C16685
 xref: NEXTPROT-FAMILY:01764
-is_a: FPLX:Histone
-inverse_is_a: UP:P68431
-inverse_is_a: UP:Q71DI3
-inverse_is_a: HGNC:HIST3H3
-inverse_is_a: UP:P84243
-inverse_is_a: HGNC:H3F3C
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:P68431 ! H31_HUMAN
+relationship: inverse_is_a UP:Q71DI3 ! H32_HUMAN
+relationship: inverse_is_a HGNC:4778 ! HIST3H3
+relationship: inverse_is_a UP:P84243 ! H33_HUMAN
+relationship: inverse_is_a HGNC:33164 ! H3F3C
 
 [Term]
-id: FPLX:Histone_H4
+id: FPLX:000238
 name: Histone-H4
 synonym: "histone H4" EXACT []
 xref: BEL:"Histone H4 Family"
@@ -4001,25 +4021,25 @@ xref: IP:IPR001951
 xref: MEDSCAN:urn:agi-protfc:histone%20H4
 xref: NCIT:C16686
 xref: NEXTPROT-FAMILY:01765
-is_a: FPLX:Histone
-inverse_is_a: UP:P62805
-inverse_is_a: HGNC:HIST1H4G
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:P62805 ! H4_HUMAN
+relationship: inverse_is_a HGNC:4792 ! HIST1H4G
 
 [Term]
-id: FPLX:HLA_DR
+id: FPLX:000239
 name: HLA-DR
 synonym: "HLA-DR" EXACT []
 xref: BEL:"HLA-DR Family"
 xref: NCIT:C16692
-is_a: FPLX:root
-inverse_is_a: HGNC:HLA-DRA
-inverse_is_a: HGNC:HLA-DRB1
-inverse_is_a: HGNC:HLA-DRB3
-inverse_is_a: HGNC:HLA-DRB4
-inverse_is_a: HGNC:HLA-DRB5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4947 ! HLA-DRA
+relationship: inverse_is_a HGNC:4948 ! HLA-DRB1
+relationship: inverse_is_a HGNC:4951 ! HLA-DRB3
+relationship: inverse_is_a HGNC:4952 ! HLA-DRB4
+relationship: inverse_is_a HGNC:4953 ! HLA-DRB5
 
 [Term]
-id: FPLX:HMOX
+id: FPLX:000240
 name: HMOX
 synonym: "haem oxygenase" EXACT []
 synonym: "heme oxygenase" EXACT []
@@ -4030,86 +4050,86 @@ xref: IP:IPR016053
 xref: IP:IPR016084
 xref: IP:IPR018207
 xref: RE:R-HSA-189382
-is_a: FPLX:root
-inverse_is_a: HGNC:HMOX1
-inverse_is_a: HGNC:HMOX2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5013 ! HMOX1
+relationship: inverse_is_a HGNC:5014 ! HMOX2
 
 [Term]
-id: FPLX:HSP90
+id: FPLX:000241
 name: HSP90
 synonym: "HSP90" EXACT []
 synonym: "Hsp90" EXACT []
 xref: BEL:"HSP90 Family"
 xref: NCIT:C17766
 xref: XFAM:PF00183
-is_a: FPLX:root
-inverse_is_a: FPLX:HSP90A
-inverse_is_a: HGNC:HSP90B1
-inverse_is_a: HGNC:TRAP1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000242 ! HSP90A
+relationship: inverse_is_a HGNC:12028 ! HSP90B1
+relationship: inverse_is_a HGNC:16264 ! TRAP1
 
 [Term]
-id: FPLX:HSP90A
+id: FPLX:000242
 name: HSP90A
 synonym: "HSP90A" EXACT []
 xref: RE:R-HSA-3371429
 xref: RE:R-HSA-419619
 xref: RE:R-HSA-5082395
 xref: RE:R-HSA-5618088
-is_a: FPLX:HSP90
-inverse_is_a: FPLX:HSP90AA
-inverse_is_a: HGNC:HSP90AB1
+is_a: FPLX:000241 ! HSP90
+relationship: inverse_is_a FPLX:000243 ! HSP90AA
+relationship: inverse_is_a HGNC:5258 ! HSP90AB1
 
 [Term]
-id: FPLX:HSP90AA
+id: FPLX:000243
 name: HSP90AA
 synonym: "HSP90AA" EXACT []
 xref: RE:R-HSA-1218829
 xref: RE:R-HSA-1221657
 xref: RE:R-HSA-5082406
-is_a: FPLX:HSP90A
-inverse_is_a: HGNC:HSP90AA1
+is_a: FPLX:000242 ! HSP90A
+relationship: inverse_is_a HGNC:5253 ! HSP90AA1
 
 [Term]
-id: FPLX:HSPA
+id: FPLX:000244
 name: HSPA
 synonym: "Heat Shock Protein 70" EXACT []
 synonym: "HSP70" EXACT []
 synonym: "Hsp70" EXACT []
 xref: BEL:"HSPA Family"
 xref: XFAM:PF00012
-is_a: FPLX:root
-inverse_is_a: HGNC:HSPA12A
-inverse_is_a: HGNC:HSPA12B
-inverse_is_a: HGNC:HSPA13
-inverse_is_a: HGNC:HSPA14
-inverse_is_a: HGNC:HSPA1A
-inverse_is_a: HGNC:HSPA1B
-inverse_is_a: HGNC:HSPA1L
-inverse_is_a: HGNC:HSPA2
-inverse_is_a: HGNC:HSPA4
-inverse_is_a: HGNC:HSPA4L
-inverse_is_a: HGNC:HSPA5
-inverse_is_a: HGNC:HSPA6
-inverse_is_a: HGNC:HSPA8
-inverse_is_a: HGNC:HSPA9
-inverse_is_a: HGNC:HSPH1
-inverse_is_a: HGNC:HYOU1
-
-[Term]
-id: FPLX:HSPB
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:19022 ! HSPA12A
+relationship: inverse_is_a HGNC:16193 ! HSPA12B
+relationship: inverse_is_a HGNC:11375 ! HSPA13
+relationship: inverse_is_a HGNC:29526 ! HSPA14
+relationship: inverse_is_a HGNC:5232 ! HSPA1A
+relationship: inverse_is_a HGNC:5233 ! HSPA1B
+relationship: inverse_is_a HGNC:5234 ! HSPA1L
+relationship: inverse_is_a HGNC:5235 ! HSPA2
+relationship: inverse_is_a HGNC:5237 ! HSPA4
+relationship: inverse_is_a HGNC:17041 ! HSPA4L
+relationship: inverse_is_a HGNC:5238 ! HSPA5
+relationship: inverse_is_a HGNC:5239 ! HSPA6
+relationship: inverse_is_a HGNC:5241 ! HSPA8
+relationship: inverse_is_a HGNC:5244 ! HSPA9
+relationship: inverse_is_a HGNC:16969 ! HSPH1
+relationship: inverse_is_a HGNC:16931 ! HYOU1
+
+[Term]
+id: FPLX:000245
 name: HSPB
 synonym: "heat shock protein family B" EXACT []
 synonym: "HSPB proteins" EXACT []
 synonym: "HSPB" EXACT []
 synonym: "small HSPs" EXACT []
 xref: BEL:"HSPB Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:HSPB1
-inverse_is_a: HGNC:HSPB2
-inverse_is_a: HGNC:HSPB8
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5246 ! HSPB1
+relationship: inverse_is_a HGNC:5247 ! HSPB2
+relationship: inverse_is_a HGNC:30171 ! HSPB8
 
 [Term]
-id: FPLX:IFNA
+id: FPLX:000246
 name: IFNA
 synonym: "IFN-a" EXACT []
 synonym: "IFN-alpha" EXACT []
@@ -4118,23 +4138,23 @@ synonym: "IFNalpha" EXACT []
 synonym: "IFNα" EXACT []
 xref: BEL:"IFNA Family"
 xref: RE:R-HSA-909688
-is_a: FPLX:Interferon
-inverse_is_a: HGNC:IFNA1
-inverse_is_a: HGNC:IFNA2
-inverse_is_a: HGNC:IFNA4
-inverse_is_a: HGNC:IFNA5
-inverse_is_a: HGNC:IFNA6
-inverse_is_a: HGNC:IFNA7
-inverse_is_a: HGNC:IFNA8
-inverse_is_a: HGNC:IFNA10
-inverse_is_a: HGNC:IFNA13
-inverse_is_a: HGNC:IFNA14
-inverse_is_a: HGNC:IFNA16
-inverse_is_a: HGNC:IFNA17
-inverse_is_a: HGNC:IFNA21
-
-[Term]
-id: FPLX:IFNB
+is_a: FPLX:000262 ! Interferon
+relationship: inverse_is_a HGNC:5417 ! IFNA1
+relationship: inverse_is_a HGNC:5423 ! IFNA2
+relationship: inverse_is_a HGNC:5425 ! IFNA4
+relationship: inverse_is_a HGNC:5426 ! IFNA5
+relationship: inverse_is_a HGNC:5427 ! IFNA6
+relationship: inverse_is_a HGNC:5428 ! IFNA7
+relationship: inverse_is_a HGNC:5429 ! IFNA8
+relationship: inverse_is_a HGNC:5418 ! IFNA10
+relationship: inverse_is_a HGNC:5419 ! IFNA13
+relationship: inverse_is_a HGNC:5420 ! IFNA14
+relationship: inverse_is_a HGNC:5421 ! IFNA16
+relationship: inverse_is_a HGNC:5422 ! IFNA17
+relationship: inverse_is_a HGNC:5424 ! IFNA21
+
+[Term]
+id: FPLX:000247
 name: IFNB
 synonym: "beta interferons" EXACT []
 synonym: "IFN-beta" EXACT []
@@ -4146,11 +4166,11 @@ synonym: "interferon β" EXACT []
 synonym: "β interferons" EXACT []
 xref: IP:IPR015588
 xref: NCIT:C20495
-is_a: FPLX:Interferon
-inverse_is_a: HGNC:IFNB1
+is_a: FPLX:000262 ! Interferon
+relationship: inverse_is_a HGNC:5434 ! IFNB1
 
 [Term]
-id: FPLX:IGFBP
+id: FPLX:000248
 name: IGFBP
 synonym: "IGF-BP" EXACT []
 synonym: "IGFBP" EXACT []
@@ -4159,25 +4179,25 @@ synonym: "insulin-like growth factor binding proteins" EXACT []
 xref: BEL:"IGFBP Family"
 xref: MEDSCAN:urn:agi-aopfc:0000586
 xref: XFAM:PF00219
-is_a: FPLX:root
-inverse_is_a: HGNC:IGFBP1
-inverse_is_a: HGNC:IGFBP2
-inverse_is_a: HGNC:IGFBP3
-inverse_is_a: HGNC:IGFBP4
-inverse_is_a: HGNC:IGFBP5
-inverse_is_a: HGNC:IGFBP6
-inverse_is_a: HGNC:IGFBP7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5469 ! IGFBP1
+relationship: inverse_is_a HGNC:5471 ! IGFBP2
+relationship: inverse_is_a HGNC:5472 ! IGFBP3
+relationship: inverse_is_a HGNC:5473 ! IGFBP4
+relationship: inverse_is_a HGNC:5474 ! IGFBP5
+relationship: inverse_is_a HGNC:5475 ! IGFBP6
+relationship: inverse_is_a HGNC:5476 ! IGFBP7
 
 [Term]
-id: FPLX:IKB
+id: FPLX:000249
 name: IKB
 synonym: "IkappaB" EXACT []
 synonym: "IκB" EXACT []
 xref: NCIT:C17583
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:IKK_complex
+id: FPLX:000250
 name: IKK-complex
 synonym: "IKK complex" EXACT []
 xref: BEL:"IkappaB Kinase Complex"
@@ -4189,13 +4209,13 @@ xref: RE:R-HSA-202513
 xref: RE:R-HSA-202562
 xref: RE:R-HSA-5262981
 xref: RE:R-HSA-727820
-is_a: FPLX:root
-has_part: HGNC:CHUK
-has_part: HGNC:IKBKB
-has_part: HGNC:IKBKG
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1974 ! CHUK
+relationship: has_part HGNC:5960 ! IKBKB
+relationship: has_part HGNC:5961 ! IKBKG
 
 [Term]
-id: FPLX:IKK_family
+id: FPLX:000251
 name: IKK-family
 synonym: "IkappaB kinase" EXACT []
 synonym: "IKK" EXACT []
@@ -4203,15 +4223,15 @@ synonym: "IκB kinase" EXACT []
 xref: BEL:"IkappaB Kinase Family"
 xref: NCIT:C104199
 xref: NEXTPROT-FAMILY:03104
-is_a: FPLX:root
-inverse_is_a: HGNC:CHUK
-inverse_is_a: HGNC:IKBKB
-inverse_is_a: HGNC:IKBKG
-inverse_is_a: HGNC:IKBKE
-inverse_is_a: HGNC:TBK1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1974 ! CHUK
+relationship: inverse_is_a HGNC:5960 ! IKBKB
+relationship: inverse_is_a HGNC:5961 ! IKBKG
+relationship: inverse_is_a HGNC:14552 ! IKBKE
+relationship: inverse_is_a HGNC:11584 ! TBK1
 
 [Term]
-id: FPLX:IL1
+id: FPLX:000252
 name: IL1
 synonym: "IL-1" EXACT []
 synonym: "IL1 family" EXACT []
@@ -4222,12 +4242,12 @@ xref: NCIT:C20506
 xref: NEXTPROT-FAMILY:01820
 xref: XFAM:PF00340
 xref: RE:R-HSA-445744
-is_a: FPLX:root
-inverse_is_a: HGNC:IL1A
-inverse_is_a: HGNC:IL1B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5991 ! IL1A
+relationship: inverse_is_a HGNC:5992 ! IL1B
 
 [Term]
-id: FPLX:IL12
+id: FPLX:000253
 name: IL12
 synonym: "IL-12" EXACT []
 synonym: "IL12" EXACT []
@@ -4238,67 +4258,67 @@ xref: RE:R-HSA-447102
 xref: RE:R-HSA-8950122
 xref: RE:R-HSA-8950228
 xref: RE:R-HSA-8950694
-is_a: FPLX:root
-inverse_is_a: HGNC:IL12A
-inverse_is_a: HGNC:IL12B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5969 ! IL12A
+relationship: inverse_is_a HGNC:5970 ! IL12B
 
 [Term]
-id: FPLX:IL15R
+id: FPLX:000254
 name: IL15R
 synonym: "IL-15 receptor" EXACT []
 synonym: "IL-15R" EXACT []
-is_a: FPLX:root
-has_part: HGNC:IL15RA
-has_part: HGNC:IL2RB
-has_part: HGNC:IL2RG
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:5978 ! IL15RA
+relationship: has_part HGNC:6009 ! IL2RB
+relationship: has_part HGNC:6010 ! IL2RG
 
 [Term]
-id: FPLX:IL2R
+id: FPLX:000255
 name: IL2R
 synonym: "IL-2 receptor" EXACT []
 synonym: "IL-2R" EXACT []
-is_a: FPLX:root
-has_part: HGNC:IL2RA
-has_part: HGNC:IL2RB
-has_part: HGNC:IL2RG
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:6008 ! IL2RA
+relationship: has_part HGNC:6009 ! IL2RB
+relationship: has_part HGNC:6010 ! IL2RG
 
 [Term]
-id: FPLX:Inhibin
+id: FPLX:000256
 name: Inhibin
 synonym: "Inhibin" EXACT []
 synonym: "inhibin" EXACT []
 xref: GO:0043511
 xref: NCIT:C2276
 xref: RE:R-HSA-1449688
-is_a: FPLX:root
-inverse_is_a: FPLX:Inhibin_A
-inverse_is_a: FPLX:Inhibin_B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000257 ! Inhibin_A
+relationship: inverse_is_a FPLX:000258 ! Inhibin_B
 
 [Term]
-id: FPLX:Inhibin_A
+id: FPLX:000257
 name: Inhibin-A
 synonym: "inhibin A" EXACT []
 synonym: "inhibin-A" EXACT []
 synonym: "inhibin-a" EXACT []
 xref: MEDSCAN:urn:agi-complex:inhibin%20A
 xref: NCIT:C2277
-is_a: FPLX:Inhibin
-has_part: HGNC:INHA
-has_part: HGNC:INHBA
+is_a: FPLX:000256 ! Inhibin
+relationship: has_part HGNC:6065 ! INHA
+relationship: has_part HGNC:6066 ! INHBA
 
 [Term]
-id: FPLX:Inhibin_B
+id: FPLX:000258
 name: Inhibin-B
 synonym: "inhibin B" EXACT []
 synonym: "inhibin-B" EXACT []
 synonym: "inhibin-b" EXACT []
 xref: NCIT:C2278
-is_a: FPLX:Inhibin
-has_part: HGNC:INHA
-has_part: HGNC:INHBB
+is_a: FPLX:000256 ! Inhibin
+relationship: has_part HGNC:6065 ! INHA
+relationship: has_part HGNC:6067 ! INHBB
 
 [Term]
-id: FPLX:INS
+id: FPLX:000259
 name: INS
 synonym: "insulin family" EXACT []
 xref: BEL:"INS Family"
@@ -4310,11 +4330,11 @@ xref: RE:R-HSA-429407
 xref: RE:R-HSA-429472
 xref: RE:R-HSA-74674
 xref: RE:R-HSA-77385
-is_a: FPLX:root
-inverse_is_a: HGNC:INS
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6081 ! INS
 
 [Term]
-id: FPLX:INSR
+id: FPLX:000260
 name: INSR
 synonym: "Insulin receptor family" EXACT []
 synonym: "insulin receptor family" EXACT []
@@ -4323,13 +4343,13 @@ xref: BEL:"INSR Family"
 xref: IP:IPR016246
 xref: MEDSCAN:urn:agi-aopfc:0000264
 xref: NEXTPROT-FAMILY:03128
-is_a: FPLX:root
-inverse_is_a: HGNC:IGF1R
-inverse_is_a: HGNC:INSR
-inverse_is_a: HGNC:INSRR
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5465 ! IGF1R
+relationship: inverse_is_a HGNC:6091 ! INSR
+relationship: inverse_is_a HGNC:6093 ! INSRR
 
 [Term]
-id: FPLX:Integrins
+id: FPLX:000261
 name: Integrins
 synonym: "alpha2beta1 integrin" EXACT []
 synonym: "integrin" EXACT []
@@ -4342,24 +4362,24 @@ xref: GO:0034683
 xref: GO:0034687
 xref: MEDSCAN:urn:agi-complex:MAC-1%20(integrin)
 xref: NCIT:C16748
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:Interferon
+id: FPLX:000262
 name: Interferon
 synonym: "IFN" EXACT []
 synonym: "interferon" EXACT []
 xref: MEDSCAN:urn:agi-protfc:interferon
 xref: NCIT:C20493
 xref: XFAM:PF00143
-is_a: FPLX:root
-inverse_is_a: FPLX:IFNA
-inverse_is_a: FPLX:IFNB
-inverse_is_a: HGNC:IFNK
-inverse_is_a: HGNC:IFNW1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000246 ! IFNA
+relationship: inverse_is_a FPLX:000247 ! IFNB
+relationship: inverse_is_a HGNC:21714 ! IFNK
+relationship: inverse_is_a HGNC:5448 ! IFNW1
 
 [Term]
-id: FPLX:Interferon_gamma_receptor
+id: FPLX:000263
 name: Interferon-gamma-receptor
 synonym: "IFNGR" EXACT []
 synonym: "interferon gamma receptor" EXACT []
@@ -4368,12 +4388,12 @@ synonym: "interferon-gamma receptor" EXACT []
 synonym: "interferon-γ receptor" EXACT []
 xref: BEL:"Interferon Gamma Receptor Complex"
 xref: MEDSCAN:urn:agi-complex:IFNGR
-is_a: FPLX:root
-has_part: HGNC:IFNGR1
-has_part: HGNC:IFNGR2
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:5439 ! IFNGR1
+relationship: has_part HGNC:5440 ! IFNGR2
 
 [Term]
-id: FPLX:IRS
+id: FPLX:000264
 name: IRS
 synonym: "insulin receptor substrate" EXACT []
 synonym: "IRS family" EXACT []
@@ -4383,30 +4403,30 @@ xref: MEDSCAN:urn:agi-aopfc:0000585
 xref: XFAM:PF02174
 xref: RE:R-HSA-2445131
 xref: RE:R-HSA-2445139
-is_a: FPLX:root
-inverse_is_a: HGNC:IRS1
-inverse_is_a: HGNC:IRS2
-inverse_is_a: HGNC:IRS4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6125 ! IRS1
+relationship: inverse_is_a HGNC:6126 ! IRS2
+relationship: inverse_is_a HGNC:6128 ! IRS4
 
 [Term]
-id: FPLX:IRX
+id: FPLX:000265
 name: IRX
 synonym: "homeodomain iroquois proteins" EXACT []
 synonym: "Iroquois family" EXACT []
 synonym: "Iroquois proteins" EXACT []
 synonym: "Iroquois-class homeodomain proteins" EXACT []
 xref: BEL:"IRX Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:IRX1
-inverse_is_a: HGNC:IRX2
-inverse_is_a: HGNC:IRX3
-inverse_is_a: HGNC:IRX4
-inverse_is_a: HGNC:IRX5
-inverse_is_a: HGNC:IRX6
-inverse_is_a: HGNC:MKX
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:14358 ! IRX1
+relationship: inverse_is_a HGNC:14359 ! IRX2
+relationship: inverse_is_a HGNC:14360 ! IRX3
+relationship: inverse_is_a HGNC:6129 ! IRX4
+relationship: inverse_is_a HGNC:14361 ! IRX5
+relationship: inverse_is_a HGNC:14675 ! IRX6
+relationship: inverse_is_a HGNC:23729 ! MKX
 
 [Term]
-id: FPLX:JAK
+id: FPLX:000266
 name: JAK
 synonym: "JAK" EXACT []
 synonym: "Jak" EXACT []
@@ -4415,14 +4435,14 @@ xref: BEL:"JAK Family"
 xref: IP:IPR016251
 xref: MEDSCAN:urn:agi-aopfc:0000464
 xref: NEXTPROT-FAMILY:03129
-is_a: FPLX:root
-inverse_is_a: HGNC:JAK1
-inverse_is_a: HGNC:JAK2
-inverse_is_a: HGNC:JAK3
-inverse_is_a: HGNC:TYK2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6190 ! JAK1
+relationship: inverse_is_a HGNC:6192 ! JAK2
+relationship: inverse_is_a HGNC:6193 ! JAK3
+relationship: inverse_is_a HGNC:12440 ! TYK2
 
 [Term]
-id: FPLX:JNK
+id: FPLX:000267
 name: JNK
 synonym: "c-JNK" EXACT []
 synonym: "c-Jun N-terminal kinase" EXACT []
@@ -4438,66 +4458,66 @@ xref: RE:R-HSA-450226
 xref: RE:R-HSA-450253
 xref: RE:R-HSA-450289
 xref: SIGNOR:SIGNOR-PF15
-is_a: FPLX:MAPK
-inverse_is_a: HGNC:MAPK8
-inverse_is_a: HGNC:MAPK9
-inverse_is_a: HGNC:MAPK10
+is_a: FPLX:000283 ! MAPK
+relationship: inverse_is_a HGNC:6881 ! MAPK8
+relationship: inverse_is_a HGNC:6886 ! MAPK9
+relationship: inverse_is_a HGNC:6872 ! MAPK10
 
 [Term]
-id: FPLX:JUN_family
+id: FPLX:000268
 name: JUN-family
 synonym: "JUN" EXACT []
 xref: IP:IPR002112
 xref: IP:IPR005643
 xref: MEDSCAN:urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75
-part_of: FPLX:AP1
-inverse_is_a: HGNC:JUN
-inverse_is_a: HGNC:JUNB
-inverse_is_a: HGNC:JUND
+relationship: part_of FPLX:000048 ! AP1
+relationship: inverse_is_a HGNC:6204 ! JUN
+relationship: inverse_is_a HGNC:6205 ! JUNB
+relationship: inverse_is_a HGNC:6206 ! JUND
 
 [Term]
-id: FPLX:Kainate_family
+id: FPLX:000269
 name: Kainate-family
 synonym: "Glutamate receptors, ionotropic, kainate" EXACT []
 synonym: "Kainate receptors" EXACT []
 synonym: "KARs" EXACT []
 xref: GFAM:1199
-is_a: FPLX:root
-inverse_is_a: HGNC:GRIK1
-inverse_is_a: HGNC:GRIK2
-inverse_is_a: HGNC:GRIK3
-inverse_is_a: HGNC:GRIK4
-inverse_is_a: HGNC:GRIK5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4579 ! GRIK1
+relationship: inverse_is_a HGNC:4580 ! GRIK2
+relationship: inverse_is_a HGNC:4581 ! GRIK3
+relationship: inverse_is_a HGNC:4582 ! GRIK4
+relationship: inverse_is_a HGNC:4583 ! GRIK5
 
 [Term]
-id: FPLX:Kinetochore
+id: FPLX:000270
 name: Kinetochore
 synonym: "kinetochore complex" EXACT []
 synonym: "kinetochore" EXACT []
 synonym: "kinetochores" EXACT []
 xref: BEL:"Kinetochore Complex"
 xref: GO:0000776
-is_a: FPLX:root
-has_part: HGNC:BUB1
-has_part: HGNC:BUB1B
-has_part: HGNC:BUB3
-has_part: HGNC:CENPC
-has_part: HGNC:CENPE
-has_part: HGNC:CENPF
-has_part: HGNC:CENPH
-has_part: HGNC:DCTN2
-has_part: HGNC:KIF22
-has_part: HGNC:MAD2L1
-has_part: HGNC:PAFAH1B1
-has_part: HGNC:PSEN1
-has_part: HGNC:PSEN2
-has_part: HGNC:SMC1A
-has_part: HGNC:SUGT1
-has_part: HGNC:SUMO3
-has_part: HGNC:ZW10
-
-[Term]
-id: FPLX:KLK
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1148 ! BUB1
+relationship: has_part HGNC:1149 ! BUB1B
+relationship: has_part HGNC:1151 ! BUB3
+relationship: has_part HGNC:1854 ! CENPC
+relationship: has_part HGNC:1856 ! CENPE
+relationship: has_part HGNC:1857 ! CENPF
+relationship: has_part HGNC:17268 ! CENPH
+relationship: has_part HGNC:2712 ! DCTN2
+relationship: has_part HGNC:6391 ! KIF22
+relationship: has_part HGNC:6763 ! MAD2L1
+relationship: has_part HGNC:8574 ! PAFAH1B1
+relationship: has_part HGNC:9508 ! PSEN1
+relationship: has_part HGNC:9509 ! PSEN2
+relationship: has_part HGNC:11111 ! SMC1A
+relationship: has_part HGNC:16987 ! SUGT1
+relationship: has_part HGNC:11124 ! SUMO3
+relationship: has_part HGNC:13194 ! ZW10
+
+[Term]
+id: FPLX:000271
 name: KLK
 synonym: "kallikrein" EXACT []
 synonym: "kallikrein-related peptidases" EXACT []
@@ -4507,47 +4527,47 @@ synonym: "tissue kallikreins" EXACT []
 xref: BEL:"KLK Family"
 xref: ECCODE:3.4.21.35
 xref: MEDSCAN:urn:agi-protfc:kallikrein
-is_a: FPLX:root
-inverse_is_a: HGNC:KLK1
-inverse_is_a: HGNC:KLK10
-inverse_is_a: HGNC:KLK11
-inverse_is_a: HGNC:KLK12
-inverse_is_a: HGNC:KLK13
-inverse_is_a: HGNC:KLK14
-inverse_is_a: HGNC:KLK15
-inverse_is_a: HGNC:KLK2
-inverse_is_a: HGNC:KLK3
-inverse_is_a: HGNC:KLK4
-inverse_is_a: HGNC:KLK5
-inverse_is_a: HGNC:KLK6
-inverse_is_a: HGNC:KLK7
-inverse_is_a: HGNC:KLK8
-inverse_is_a: HGNC:KLK9
-inverse_is_a: HGNC:KLKB1
-
-[Term]
-id: FPLX:KSR
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6357 ! KLK1
+relationship: inverse_is_a HGNC:6358 ! KLK10
+relationship: inverse_is_a HGNC:6359 ! KLK11
+relationship: inverse_is_a HGNC:6360 ! KLK12
+relationship: inverse_is_a HGNC:6361 ! KLK13
+relationship: inverse_is_a HGNC:6362 ! KLK14
+relationship: inverse_is_a HGNC:20453 ! KLK15
+relationship: inverse_is_a HGNC:6363 ! KLK2
+relationship: inverse_is_a HGNC:6364 ! KLK3
+relationship: inverse_is_a HGNC:6365 ! KLK4
+relationship: inverse_is_a HGNC:6366 ! KLK5
+relationship: inverse_is_a HGNC:6367 ! KLK6
+relationship: inverse_is_a HGNC:6368 ! KLK7
+relationship: inverse_is_a HGNC:6369 ! KLK8
+relationship: inverse_is_a HGNC:6370 ! KLK9
+relationship: inverse_is_a HGNC:6371 ! KLKB1
+
+[Term]
+id: FPLX:000272
 name: KSR
 synonym: "KSR" EXACT []
 xref: IP:IPR025561
-is_a: FPLX:root
-inverse_is_a: HGNC:KSR1
-inverse_is_a: HGNC:KSR2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6465 ! KSR1
+relationship: inverse_is_a HGNC:18610 ! KSR2
 
 [Term]
-id: FPLX:Laminin_111
+id: FPLX:000273
 name: Laminin-111
 synonym: "LM-1" EXACT []
 xref: BEL:"Laminin 1 Complex"
 xref: RE:R-HSA-215989
 xref: RE:R-HSA-2426371
-is_a: FPLX:root
-has_part: HGNC:LAMA1
-has_part: HGNC:LAMB1
-has_part: HGNC:LAMC1
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:6481 ! LAMA1
+relationship: has_part HGNC:6486 ! LAMB1
+relationship: has_part HGNC:6492 ! LAMC1
 
 [Term]
-id: FPLX:Laminin_332
+id: FPLX:000274
 name: Laminin-332
 synonym: "laminin 332 chains" EXACT []
 synonym: "laminin 332" EXACT []
@@ -4561,25 +4581,25 @@ xref: RE:R-HSA-216001
 xref: RE:R-HSA-2220790
 xref: RE:R-HSA-2399659
 xref: RE:R-HSA-2533911
-is_a: FPLX:root
-has_part: HGNC:LAMA3
-has_part: HGNC:LAMB3
-has_part: HGNC:LAMC2
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:6483 ! LAMA3
+relationship: has_part HGNC:6490 ! LAMB3
+relationship: has_part HGNC:6493 ! LAMC2
 
 [Term]
-id: FPLX:LDH
+id: FPLX:000275
 name: LDH
 synonym: "LDH" EXACT []
 xref: BEL:"LDH Family"
 xref: NCIT:C25184
 xref: NEXTPROT-FAMILY:02022
-is_a: FPLX:root
-inverse_is_a: HGNC:LDHA
-inverse_is_a: HGNC:LDHB
-inverse_is_a: HGNC:LDHC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6535 ! LDHA
+relationship: inverse_is_a HGNC:6541 ! LDHB
+relationship: inverse_is_a HGNC:6544 ! LDHC
 
 [Term]
-id: FPLX:LH
+id: FPLX:000276
 name: LH
 synonym: "LH" EXACT []
 synonym: "Luteinizing hormone" EXACT []
@@ -4590,21 +4610,21 @@ xref: MEDSCAN:urn:agi-complex:Luteinizing%20hormone
 xref: RE:R-HSA-378969
 xref: RE:R-HSA-6793931
 xref: RE:R-HSA-6793934
-is_a: FPLX:root
-has_part: HGNC:CGA
-has_part: HGNC:LHB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1885 ! CGA
+relationship: has_part HGNC:6584 ! LHB
 
 [Term]
-id: FPLX:LPAR
+id: FPLX:000277
 name: LPAR
 xref: SIGNOR:SIGNOR-PF2
-is_a: FPLX:root
-inverse_is_a: HGNC:LPAR1
-inverse_is_a: HGNC:LPAR2
-inverse_is_a: HGNC:LPAR3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3166 ! LPAR1
+relationship: inverse_is_a HGNC:3168 ! LPAR2
+relationship: inverse_is_a HGNC:14298 ! LPAR3
 
 [Term]
-id: FPLX:MAC
+id: FPLX:000278
 name: MAC
 synonym: "MAC" EXACT []
 synonym: "membrane attack complex" EXACT []
@@ -4613,17 +4633,17 @@ xref: BEL:"Membrane Attack Complex"
 xref: GO:0005579
 xref: RE:R-HSA-173728
 xref: RE:R-HSA-8852568
-is_a: FPLX:root
-has_part: HGNC:C5
-has_part: HGNC:C6
-has_part: HGNC:C7
-has_part: HGNC:C8A
-has_part: HGNC:C8B
-has_part: HGNC:C8G
-has_part: HGNC:C9
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1331 ! C5
+relationship: has_part HGNC:1339 ! C6
+relationship: has_part HGNC:1346 ! C7
+relationship: has_part HGNC:1352 ! C8A
+relationship: has_part HGNC:1353 ! C8B
+relationship: has_part HGNC:1354 ! C8G
+relationship: has_part HGNC:1358 ! C9
 
 [Term]
-id: FPLX:MAF
+id: FPLX:000279
 name: MAF
 synonym: "Maf subfamily" EXACT []
 synonym: "MAF" EXACT []
@@ -4633,71 +4653,71 @@ xref: BEL:"MAF Family"
 xref: IP:IPR004826
 xref: MEDSCAN:urn:agi-aopfc:0000142
 xref: XFAM:PF02545
-is_a: FPLX:root
-inverse_is_a: HGNC:MAF
-inverse_is_a: HGNC:MAFA
-inverse_is_a: HGNC:MAFB
-inverse_is_a: HGNC:MAFF
-inverse_is_a: HGNC:MAFG
-inverse_is_a: HGNC:MAFK
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6776 ! MAF
+relationship: inverse_is_a HGNC:23145 ! MAFA
+relationship: inverse_is_a HGNC:6408 ! MAFB
+relationship: inverse_is_a HGNC:6780 ! MAFF
+relationship: inverse_is_a HGNC:6781 ! MAFG
+relationship: inverse_is_a HGNC:6782 ! MAFK
 
 [Term]
-id: FPLX:MAP1LC3
+id: FPLX:000280
 name: MAP1LC3
 synonym: "LC3" EXACT []
 xref: IP:IPR004241
-is_a: FPLX:root
-inverse_is_a: HGNC:MAP1LC3A
-inverse_is_a: HGNC:MAP1LC3B
-inverse_is_a: HGNC:MAP1LC3B2
-inverse_is_a: HGNC:MAP1LC3C
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6838 ! MAP1LC3A
+relationship: inverse_is_a HGNC:13352 ! MAP1LC3B
+relationship: inverse_is_a HGNC:34390 ! MAP1LC3B2
+relationship: inverse_is_a HGNC:13353 ! MAP1LC3C
 
 [Term]
-id: FPLX:MAP2K
+id: FPLX:000281
 name: MAP2K
 synonym: "MAPK kinase" EXACT []
 synonym: "mitogen-activated protein kinase kinase" EXACT []
 xref: NCIT:C105947
-is_a: FPLX:root
-inverse_is_a: FPLX:MEK
-inverse_is_a: HGNC:MAP2K3
-inverse_is_a: HGNC:MAP2K4
-inverse_is_a: HGNC:MAP2K5
-inverse_is_a: HGNC:MAP2K6
-inverse_is_a: HGNC:MAP2K7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000286 ! MEK
+relationship: inverse_is_a HGNC:6843 ! MAP2K3
+relationship: inverse_is_a HGNC:6844 ! MAP2K4
+relationship: inverse_is_a HGNC:6845 ! MAP2K5
+relationship: inverse_is_a HGNC:6846 ! MAP2K6
+relationship: inverse_is_a HGNC:6847 ! MAP2K7
 
 [Term]
-id: FPLX:MAP3K
+id: FPLX:000282
 name: MAP3K
 synonym: "MAP3K" EXACT []
 synonym: "MAPK kinase kinase" EXACT []
 synonym: "MAPKK kinases" EXACT []
 synonym: "MAPKKK" EXACT []
 xref: ECCODE:2.7.11.25
-is_a: FPLX:root
-inverse_is_a: FPLX:RAF
-inverse_is_a: HGNC:MAP3K1
-inverse_is_a: HGNC:MAP3K2
-inverse_is_a: HGNC:MAP3K3
-inverse_is_a: HGNC:MAP3K4
-inverse_is_a: HGNC:MAP3K5
-inverse_is_a: HGNC:MAP3K6
-inverse_is_a: HGNC:MAP3K7
-inverse_is_a: HGNC:MAP3K8
-inverse_is_a: HGNC:MAP3K9
-inverse_is_a: HGNC:MAP3K10
-inverse_is_a: HGNC:MAP3K11
-inverse_is_a: HGNC:MAP3K12
-inverse_is_a: HGNC:MAP3K13
-inverse_is_a: HGNC:MAP3K14
-inverse_is_a: HGNC:MAP3K15
-inverse_is_a: FPLX:TAOK
-inverse_is_a: HGNC:MAP3K19
-inverse_is_a: HGNC:MAP3K20
-inverse_is_a: HGNC:MAP3K21
-
-[Term]
-id: FPLX:MAPK
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000399 ! RAF
+relationship: inverse_is_a HGNC:6848 ! MAP3K1
+relationship: inverse_is_a HGNC:6854 ! MAP3K2
+relationship: inverse_is_a HGNC:6855 ! MAP3K3
+relationship: inverse_is_a HGNC:6856 ! MAP3K4
+relationship: inverse_is_a HGNC:6857 ! MAP3K5
+relationship: inverse_is_a HGNC:6858 ! MAP3K6
+relationship: inverse_is_a HGNC:6859 ! MAP3K7
+relationship: inverse_is_a HGNC:6860 ! MAP3K8
+relationship: inverse_is_a HGNC:6861 ! MAP3K9
+relationship: inverse_is_a HGNC:6849 ! MAP3K10
+relationship: inverse_is_a HGNC:6850 ! MAP3K11
+relationship: inverse_is_a HGNC:6851 ! MAP3K12
+relationship: inverse_is_a HGNC:6852 ! MAP3K13
+relationship: inverse_is_a HGNC:6853 ! MAP3K14
+relationship: inverse_is_a HGNC:31689 ! MAP3K15
+relationship: inverse_is_a FPLX:000458 ! TAOK
+relationship: inverse_is_a HGNC:26249 ! MAP3K19
+relationship: inverse_is_a HGNC:17797 ! MAP3K20
+relationship: inverse_is_a HGNC:29798 ! MAP3K21
+
+[Term]
+id: FPLX:000283
 name: MAPK
 synonym: "MAP kinase" EXACT []
 synonym: "MAP kinases" EXACT []
@@ -4709,13 +4729,13 @@ synonym: "mitogen-activated protein kinases" EXACT []
 xref: ECCODE:2.7.11.24
 xref: ECCODE:2.7.12.2
 xref: NCIT:C16376
-is_a: FPLX:root
-inverse_is_a: FPLX:ERK
-inverse_is_a: FPLX:p38
-inverse_is_a: FPLX:JNK
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000161 ! ERK
+relationship: inverse_is_a FPLX:000326 ! p38
+relationship: inverse_is_a FPLX:000267 ! JNK
 
 [Term]
-id: FPLX:MCM
+id: FPLX:000284
 name: MCM
 synonym: "MCM" EXACT []
 synonym: "mini-chromosome maintenance complex" EXACT []
@@ -4727,19 +4747,19 @@ xref: IP:IPR031327
 xref: MEDSCAN:urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1
 xref: NEXTPROT-FAMILY:02187
 xref: XFAM:PF00493
-is_a: FPLX:root
-inverse_is_a: HGNC:MCM2
-inverse_is_a: HGNC:MCM3
-inverse_is_a: HGNC:MCM4
-inverse_is_a: HGNC:MCM5
-inverse_is_a: HGNC:MCM6
-inverse_is_a: HGNC:MCM7
-inverse_is_a: HGNC:MCM8
-inverse_is_a: HGNC:MCM9
-inverse_is_a: HGNC:MCMDC2
-
-[Term]
-id: FPLX:MEF2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6944 ! MCM2
+relationship: inverse_is_a HGNC:6945 ! MCM3
+relationship: inverse_is_a HGNC:6947 ! MCM4
+relationship: inverse_is_a HGNC:6948 ! MCM5
+relationship: inverse_is_a HGNC:6949 ! MCM6
+relationship: inverse_is_a HGNC:6950 ! MCM7
+relationship: inverse_is_a HGNC:16147 ! MCM8
+relationship: inverse_is_a HGNC:21484 ! MCM9
+relationship: inverse_is_a HGNC:26368 ! MCMDC2
+
+[Term]
+id: FPLX:000285
 name: MEF2
 synonym: "MEF2 family" EXACT []
 synonym: "MEF2" EXACT []
@@ -4748,14 +4768,14 @@ xref: IP:IPR033896
 xref: MEDSCAN:urn:agi-aopfc:0000143
 xref: RE:R-HSA-448866
 xref: RE:R-HSA-448868
-is_a: FPLX:root
-inverse_is_a: HGNC:MEF2A
-inverse_is_a: HGNC:MEF2C
-inverse_is_a: HGNC:MEF2D
-inverse_is_a: HGNC:MEF2B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6993 ! MEF2A
+relationship: inverse_is_a HGNC:6996 ! MEF2C
+relationship: inverse_is_a HGNC:6997 ! MEF2D
+relationship: inverse_is_a HGNC:6995 ! MEF2B
 
 [Term]
-id: FPLX:MEK
+id: FPLX:000286
 name: MEK
 synonym: "MEK 1/2" EXACT []
 synonym: "MEK" EXACT []
@@ -4768,27 +4788,27 @@ xref: RE:R-HSA-5672716
 xref: RE:R-HSA-5672721
 xref: RE:R-HSA-5674489
 xref: SIGNOR:SIGNOR-PF25
-is_a: FPLX:MAP2K
-inverse_is_a: HGNC:MAP2K1
-inverse_is_a: HGNC:MAP2K2
+is_a: FPLX:000281 ! MAP2K
+relationship: inverse_is_a HGNC:6840 ! MAP2K1
+relationship: inverse_is_a HGNC:6842 ! MAP2K2
 
 [Term]
-id: FPLX:MGAT
+id: FPLX:000287
 name: MGAT
 synonym: "MGAT" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:MGAT1
-inverse_is_a: HGNC:MGAT2
-inverse_is_a: HGNC:MGAT3
-inverse_is_a: HGNC:MGAT4A
-inverse_is_a: HGNC:MGAT4B
-inverse_is_a: HGNC:MGAT4C
-inverse_is_a: HGNC:MGAT4D
-inverse_is_a: HGNC:MGAT5
-inverse_is_a: HGNC:MGAT5B
-
-[Term]
-id: FPLX:Mitochondrial_Ribosome
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:7044 ! MGAT1
+relationship: inverse_is_a HGNC:7045 ! MGAT2
+relationship: inverse_is_a HGNC:7046 ! MGAT3
+relationship: inverse_is_a HGNC:7047 ! MGAT4A
+relationship: inverse_is_a HGNC:7048 ! MGAT4B
+relationship: inverse_is_a HGNC:30871 ! MGAT4C
+relationship: inverse_is_a HGNC:43619 ! MGAT4D
+relationship: inverse_is_a HGNC:7049 ! MGAT5
+relationship: inverse_is_a HGNC:24140 ! MGAT5B
+
+[Term]
+id: FPLX:000288
 name: Mitochondrial-Ribosome
 synonym: "mammalian mitochondrial ribosome" EXACT []
 synonym: "Mitochondrial ribosome" EXACT []
@@ -4804,195 +4824,195 @@ synonym: "55s mitoribosome" EXACT []
 synonym: "55S Mitoribosome" EXACT []
 synonym: "55s Mitoribosome" EXACT []
 xref: GO:0005761
-is_a: FPLX:root
-has_part: FPLX:MRPS
-has_part: FPLX:MRPL
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000289 ! MRPS
+relationship: has_part FPLX:000290 ! MRPL
 
 [Term]
-id: FPLX:MRPS
+id: FPLX:000289
 name: MRPS
 synonym: "small mitoribosomal subunit" EXACT []
 synonym: "Small Mitoribosomal Subunit" EXACT []
 synonym: "small subunit of the mammalian mitochondrial ribosome" EXACT []
 synonym: "mitochondrial ribosomal small subunit" EXACT []
 xref: GO:0005763
-part_of: FPLX:Mitochondrial_Ribosome
-has_part: HGNC:MRPS2
-has_part: HGNC:MRPS5
-has_part: HGNC:MRPS6
-has_part: HGNC:MRPS7
-has_part: HGNC:MRPS9
-has_part: HGNC:MRPS10
-has_part: HGNC:MRPS11
-has_part: HGNC:MRPS12
-has_part: HGNC:MRPS14
-has_part: HGNC:MRPS15
-has_part: HGNC:MRPS16
-has_part: HGNC:MRPS17
-has_part: HGNC:MRPS18A
-has_part: HGNC:MRPS18B
-has_part: HGNC:MRPS18C
-has_part: HGNC:MRPS21
-has_part: HGNC:MRPS22
-has_part: HGNC:MRPS23
-has_part: HGNC:MRPS24
-has_part: HGNC:MRPS25
-has_part: HGNC:MRPS26
-has_part: HGNC:MRPS27
-has_part: HGNC:MRPS28
-has_part: HGNC:DAP3
-has_part: HGNC:MRPS30
-has_part: HGNC:MRPS31
-has_part: HGNC:MRPS33
-has_part: HGNC:MRPS34
-has_part: HGNC:MRPS35
-has_part: HGNC:MRPS36
-
-[Term]
-id: FPLX:MRPL
+relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome
+relationship: has_part HGNC:14495 ! MRPS2
+relationship: has_part HGNC:14498 ! MRPS5
+relationship: has_part HGNC:14051 ! MRPS6
+relationship: has_part HGNC:14499 ! MRPS7
+relationship: has_part HGNC:14501 ! MRPS9
+relationship: has_part HGNC:14502 ! MRPS10
+relationship: has_part HGNC:14050 ! MRPS11
+relationship: has_part HGNC:10380 ! MRPS12
+relationship: has_part HGNC:14049 ! MRPS14
+relationship: has_part HGNC:14504 ! MRPS15
+relationship: has_part HGNC:14048 ! MRPS16
+relationship: has_part HGNC:14047 ! MRPS17
+relationship: has_part HGNC:14515 ! MRPS18A
+relationship: has_part HGNC:14516 ! MRPS18B
+relationship: has_part HGNC:16633 ! MRPS18C
+relationship: has_part HGNC:14046 ! MRPS21
+relationship: has_part HGNC:14508 ! MRPS22
+relationship: has_part HGNC:14509 ! MRPS23
+relationship: has_part HGNC:14510 ! MRPS24
+relationship: has_part HGNC:14511 ! MRPS25
+relationship: has_part HGNC:14045 ! MRPS26
+relationship: has_part HGNC:14512 ! MRPS27
+relationship: has_part HGNC:14513 ! MRPS28
+relationship: has_part HGNC:2673 ! DAP3
+relationship: has_part HGNC:8769 ! MRPS30
+relationship: has_part HGNC:16632 ! MRPS31
+relationship: has_part HGNC:16634 ! MRPS33
+relationship: has_part HGNC:16618 ! MRPS34
+relationship: has_part HGNC:16635 ! MRPS35
+relationship: has_part HGNC:16631 ! MRPS36
+
+[Term]
+id: FPLX:000290
 name: MRPL
 synonym: "large mitoribosomal subunit" EXACT []
 synonym: "Large Mitoribosomal Subunit" EXACT []
 synonym: "large subunit of the mammalian mitochondrial ribosome" EXACT []
 synonym: "mitochondrial ribosomal large subunit" EXACT []
 xref: GO:0005762
-part_of: FPLX:Mitochondrial_Ribosome
-has_part: HGNC:MRPL1
-has_part: HGNC:MRPL2
-has_part: HGNC:MRPL3
-has_part: HGNC:MRPL4
-has_part: HGNC:MRPL9
-has_part: HGNC:MRPL10
-has_part: HGNC:MRPL11
-has_part: HGNC:MRPL12
-has_part: HGNC:MRPL13
-has_part: HGNC:MRPL14
-has_part: HGNC:MRPL15
-has_part: HGNC:MRPL16
-has_part: HGNC:MRPL17
-has_part: HGNC:MRPL18
-has_part: HGNC:MRPL19
-has_part: HGNC:MRPL20
-has_part: HGNC:MRPL21
-has_part: HGNC:MRPL22
-has_part: HGNC:MRPL23
-has_part: HGNC:MRPL24
-has_part: HGNC:MRPL27
-has_part: HGNC:MRPL28
-has_part: HGNC:MRPL30
-has_part: HGNC:MRPL32
-has_part: HGNC:MRPL33
-has_part: HGNC:MRPL34
-has_part: HGNC:MRPL35
-has_part: HGNC:MRPL36
-has_part: HGNC:MRPL37
-has_part: HGNC:MRPL38
-has_part: HGNC:MRPL39
-has_part: HGNC:MRPL40
-has_part: HGNC:MRPL41
-has_part: HGNC:MRPL42
-has_part: HGNC:MRPL43
-has_part: HGNC:MRPL44
-has_part: HGNC:MRPL45
-has_part: HGNC:MRPL46
-has_part: HGNC:MRPL47
-has_part: HGNC:MRPL48
-has_part: HGNC:MRPL49
-has_part: HGNC:MRPL50
-has_part: HGNC:MRPL51
-has_part: HGNC:MRPL52
-has_part: HGNC:MRPL53
-has_part: HGNC:MRPL54
-has_part: HGNC:MRPL55
-has_part: HGNC:MRPL57
-
-[Term]
-id: FPLX:MMP
+relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome
+relationship: has_part HGNC:14275 ! MRPL1
+relationship: has_part HGNC:14056 ! MRPL2
+relationship: has_part HGNC:10379 ! MRPL3
+relationship: has_part HGNC:14276 ! MRPL4
+relationship: has_part HGNC:14277 ! MRPL9
+relationship: has_part HGNC:14055 ! MRPL10
+relationship: has_part HGNC:14042 ! MRPL11
+relationship: has_part HGNC:10378 ! MRPL12
+relationship: has_part HGNC:14278 ! MRPL13
+relationship: has_part HGNC:14279 ! MRPL14
+relationship: has_part HGNC:14054 ! MRPL15
+relationship: has_part HGNC:14476 ! MRPL16
+relationship: has_part HGNC:14053 ! MRPL17
+relationship: has_part HGNC:14477 ! MRPL18
+relationship: has_part HGNC:14052 ! MRPL19
+relationship: has_part HGNC:14478 ! MRPL20
+relationship: has_part HGNC:14479 ! MRPL21
+relationship: has_part HGNC:14480 ! MRPL22
+relationship: has_part HGNC:10322 ! MRPL23
+relationship: has_part HGNC:14037 ! MRPL24
+relationship: has_part HGNC:14483 ! MRPL27
+relationship: has_part HGNC:14484 ! MRPL28
+relationship: has_part HGNC:14036 ! MRPL30
+relationship: has_part HGNC:14035 ! MRPL32
+relationship: has_part HGNC:14487 ! MRPL33
+relationship: has_part HGNC:14488 ! MRPL34
+relationship: has_part HGNC:14489 ! MRPL35
+relationship: has_part HGNC:14490 ! MRPL36
+relationship: has_part HGNC:14034 ! MRPL37
+relationship: has_part HGNC:14033 ! MRPL38
+relationship: has_part HGNC:14027 ! MRPL39
+relationship: has_part HGNC:14491 ! MRPL40
+relationship: has_part HGNC:14492 ! MRPL41
+relationship: has_part HGNC:14493 ! MRPL42
+relationship: has_part HGNC:14517 ! MRPL43
+relationship: has_part HGNC:16650 ! MRPL44
+relationship: has_part HGNC:16651 ! MRPL45
+relationship: has_part HGNC:1192 ! MRPL46
+relationship: has_part HGNC:16652 ! MRPL47
+relationship: has_part HGNC:16653 ! MRPL48
+relationship: has_part HGNC:1176 ! MRPL49
+relationship: has_part HGNC:16654 ! MRPL50
+relationship: has_part HGNC:14044 ! MRPL51
+relationship: has_part HGNC:16655 ! MRPL52
+relationship: has_part HGNC:16684 ! MRPL53
+relationship: has_part HGNC:16685 ! MRPL54
+relationship: has_part HGNC:16686 ! MRPL55
+relationship: has_part HGNC:14514 ! MRPL57
+
+[Term]
+id: FPLX:000291
 name: MMP
 synonym: "MMP" EXACT []
 synonym: "MMPs" EXACT []
 xref: BEL:"MMP Family"
 xref: NCIT:C18164
-is_a: FPLX:root
-inverse_is_a: HGNC:MMP1
-inverse_is_a: HGNC:MMP2
-inverse_is_a: HGNC:MMP3
-inverse_is_a: HGNC:MMP7
-inverse_is_a: HGNC:MMP8
-inverse_is_a: HGNC:MMP9
-inverse_is_a: HGNC:MMP10
-inverse_is_a: HGNC:MMP11
-inverse_is_a: HGNC:MMP12
-inverse_is_a: HGNC:MMP13
-inverse_is_a: HGNC:MMP14
-inverse_is_a: HGNC:MMP15
-inverse_is_a: HGNC:MMP16
-inverse_is_a: HGNC:MMP17
-inverse_is_a: HGNC:MMP19
-inverse_is_a: HGNC:MMP20
-inverse_is_a: HGNC:MMP21
-inverse_is_a: HGNC:MMP23B
-inverse_is_a: HGNC:MMP24
-inverse_is_a: HGNC:MMP25
-inverse_is_a: HGNC:MMP26
-inverse_is_a: HGNC:MMP27
-inverse_is_a: HGNC:MMP28
-
-[Term]
-id: FPLX:Metallothionein
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7155 ! MMP1
+relationship: inverse_is_a HGNC:7166 ! MMP2
+relationship: inverse_is_a HGNC:7173 ! MMP3
+relationship: inverse_is_a HGNC:7174 ! MMP7
+relationship: inverse_is_a HGNC:7175 ! MMP8
+relationship: inverse_is_a HGNC:7176 ! MMP9
+relationship: inverse_is_a HGNC:7156 ! MMP10
+relationship: inverse_is_a HGNC:7157 ! MMP11
+relationship: inverse_is_a HGNC:7158 ! MMP12
+relationship: inverse_is_a HGNC:7159 ! MMP13
+relationship: inverse_is_a HGNC:7160 ! MMP14
+relationship: inverse_is_a HGNC:7161 ! MMP15
+relationship: inverse_is_a HGNC:7162 ! MMP16
+relationship: inverse_is_a HGNC:7163 ! MMP17
+relationship: inverse_is_a HGNC:7165 ! MMP19
+relationship: inverse_is_a HGNC:7167 ! MMP20
+relationship: inverse_is_a HGNC:14357 ! MMP21
+relationship: inverse_is_a HGNC:7171 ! MMP23B
+relationship: inverse_is_a HGNC:7172 ! MMP24
+relationship: inverse_is_a HGNC:14246 ! MMP25
+relationship: inverse_is_a HGNC:14249 ! MMP26
+relationship: inverse_is_a HGNC:14250 ! MMP27
+relationship: inverse_is_a HGNC:14366 ! MMP28
+
+[Term]
+id: FPLX:000292
 name: Metallothionein
 synonym: "Metallothionein" EXACT []
 synonym: "metallothionein" EXACT []
 synonym: "MT" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:MT1A
-inverse_is_a: HGNC:MT1B
-inverse_is_a: HGNC:MT1CP
-inverse_is_a: HGNC:MT1DP
-inverse_is_a: HGNC:MT1E
-inverse_is_a: HGNC:MT1F
-inverse_is_a: HGNC:MT1G
-inverse_is_a: HGNC:MT1H
-inverse_is_a: HGNC:MT1HL1
-inverse_is_a: HGNC:MT1IP
-inverse_is_a: HGNC:MT1JP
-inverse_is_a: HGNC:MT1L
-inverse_is_a: HGNC:MT1M
-inverse_is_a: HGNC:MT1P1
-inverse_is_a: HGNC:MT1P3
-inverse_is_a: HGNC:MT1X
-inverse_is_a: HGNC:MT2A
-inverse_is_a: HGNC:MT3
-inverse_is_a: HGNC:MT4
-
-[Term]
-id: FPLX:mTORC1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7393 ! MT1A
+relationship: inverse_is_a HGNC:7394 ! MT1B
+relationship: inverse_is_a HGNC:7395 ! MT1CP
+relationship: inverse_is_a HGNC:7396 ! MT1DP
+relationship: inverse_is_a HGNC:7397 ! MT1E
+relationship: inverse_is_a HGNC:7398 ! MT1F
+relationship: inverse_is_a HGNC:7399 ! MT1G
+relationship: inverse_is_a HGNC:7400 ! MT1H
+relationship: inverse_is_a HGNC:31864 ! MT1HL1
+relationship: inverse_is_a HGNC:7401 ! MT1IP
+relationship: inverse_is_a HGNC:7402 ! MT1JP
+relationship: inverse_is_a HGNC:7404 ! MT1L
+relationship: inverse_is_a HGNC:14296 ! MT1M
+relationship: inverse_is_a HGNC:23681 ! MT1P1
+relationship: inverse_is_a HGNC:16120 ! MT1P3
+relationship: inverse_is_a HGNC:7405 ! MT1X
+relationship: inverse_is_a HGNC:7406 ! MT2A
+relationship: inverse_is_a HGNC:7408 ! MT3
+relationship: inverse_is_a HGNC:18705 ! MT4
+
+[Term]
+id: FPLX:000293
 name: mTORC1
 synonym: "mTORC1" EXACT []
 synonym: "TORC1" EXACT []
 xref: GO:0031931
 xref: MEDSCAN:urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e
 xref: NCIT:C96314
-is_a: FPLX:root
-has_part: HGNC:MTOR
-has_part: HGNC:RPTOR
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3942 ! MTOR
+relationship: has_part HGNC:30287 ! RPTOR
 
 [Term]
-id: FPLX:mTORC2
+id: FPLX:000294
 name: mTORC2
 synonym: "mTORC2" EXACT []
 synonym: "TORC2" EXACT []
 xref: BEL:"TORC2 Complex"
 xref: MEDSCAN:urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168
 xref: NCIT:C96315
-is_a: FPLX:root
-has_part: HGNC:MAPKAP1
-has_part: HGNC:MTOR
-has_part: HGNC:RICTOR
-has_part: HGNC:MLST8
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:18752 ! MAPKAP1
+relationship: has_part HGNC:3942 ! MTOR
+relationship: has_part HGNC:28611 ! RICTOR
+relationship: has_part HGNC:24825 ! MLST8
 
 [Term]
-id: FPLX:MYH
+id: FPLX:000295
 name: MYH
 synonym: "myosin heavy chain genes" EXACT []
 synonym: "myosin heavy chain isoforms" EXACT []
@@ -5003,25 +5023,25 @@ synonym: "Myosin heavy chains" EXACT []
 synonym: "myosin heavy chains" EXACT []
 xref: BEL:"MYH Family"
 xref: MEDSCAN:urn:agi-protfc:myosin%20heavy%20chain
-is_a: FPLX:root
-inverse_is_a: HGNC:MYH1
-inverse_is_a: HGNC:MYH10
-inverse_is_a: HGNC:MYH11
-inverse_is_a: HGNC:MYH13
-inverse_is_a: HGNC:MYH14
-inverse_is_a: HGNC:MYH15
-inverse_is_a: HGNC:MYH2
-inverse_is_a: HGNC:MYH3
-inverse_is_a: HGNC:MYH4
-inverse_is_a: HGNC:MYH6
-inverse_is_a: HGNC:MYH7
-inverse_is_a: HGNC:MYH7B
-inverse_is_a: HGNC:MYH8
-inverse_is_a: HGNC:MYH9
-inverse_is_a: HGNC:MYO5A
-
-[Term]
-id: FPLX:MYL
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7567 ! MYH1
+relationship: inverse_is_a HGNC:7568 ! MYH10
+relationship: inverse_is_a HGNC:7569 ! MYH11
+relationship: inverse_is_a HGNC:7571 ! MYH13
+relationship: inverse_is_a HGNC:23212 ! MYH14
+relationship: inverse_is_a HGNC:31073 ! MYH15
+relationship: inverse_is_a HGNC:7572 ! MYH2
+relationship: inverse_is_a HGNC:7573 ! MYH3
+relationship: inverse_is_a HGNC:7574 ! MYH4
+relationship: inverse_is_a HGNC:7576 ! MYH6
+relationship: inverse_is_a HGNC:7577 ! MYH7
+relationship: inverse_is_a HGNC:15906 ! MYH7B
+relationship: inverse_is_a HGNC:7578 ! MYH8
+relationship: inverse_is_a HGNC:7579 ! MYH9
+relationship: inverse_is_a HGNC:7602 ! MYO5A
+
+[Term]
+id: FPLX:000296
 name: MYL
 synonym: "MLC" EXACT []
 synonym: "myosin light chain protein" EXACT []
@@ -5029,107 +5049,107 @@ synonym: "myosin light chain" EXACT []
 synonym: "myosin light chains" EXACT []
 xref: BEL:"MYL Family"
 xref: MEDSCAN:urn:agi-protfc:myosin%20light%20chain
-is_a: FPLX:root
-inverse_is_a: FPLX:MYL_alkali
-inverse_is_a: FPLX:MYL_regulatory
-inverse_is_a: FPLX:MYL_slow
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000297 ! MYL_alkali
+relationship: inverse_is_a FPLX:000298 ! MYL_regulatory
+relationship: inverse_is_a FPLX:000299 ! MYL_slow
 
 [Term]
-id: FPLX:MYL_alkali
+id: FPLX:000297
 name: MYL-alkali
 synonym: "alkali myosin light chains" EXACT []
 synonym: "AMLC" EXACT []
 synonym: "myosin alkali light chain proteins" EXACT []
 synonym: "myosin alkali light chain" EXACT []
 xref: BEL:"MYL Alkali Family"
-is_a: FPLX:MYL
-inverse_is_a: HGNC:MYL1
-inverse_is_a: HGNC:MYL3
-inverse_is_a: HGNC:MYL4
-inverse_is_a: HGNC:MYL6
-inverse_is_a: HGNC:MYL6B
+is_a: FPLX:000296 ! MYL
+relationship: inverse_is_a HGNC:7582 ! MYL1
+relationship: inverse_is_a HGNC:7584 ! MYL3
+relationship: inverse_is_a HGNC:7585 ! MYL4
+relationship: inverse_is_a HGNC:7587 ! MYL6
+relationship: inverse_is_a HGNC:29823 ! MYL6B
 
 [Term]
-id: FPLX:MYL_regulatory
+id: FPLX:000298
 name: MYL-regulatory
 synonym: "regulatory myosin light chain" EXACT []
 xref: BEL:"MYL Regulatory Family"
-is_a: FPLX:MYL
-inverse_is_a: HGNC:MYL10
-inverse_is_a: HGNC:MYL12A
-inverse_is_a: HGNC:MYL12B
-inverse_is_a: HGNC:MYL2
-inverse_is_a: HGNC:MYL5
-inverse_is_a: HGNC:MYL7
-inverse_is_a: HGNC:MYL9
-inverse_is_a: HGNC:MYLPF
-
-[Term]
-id: FPLX:MYL_slow
+is_a: FPLX:000296 ! MYL
+relationship: inverse_is_a HGNC:29825 ! MYL10
+relationship: inverse_is_a HGNC:16701 ! MYL12A
+relationship: inverse_is_a HGNC:29827 ! MYL12B
+relationship: inverse_is_a HGNC:7583 ! MYL2
+relationship: inverse_is_a HGNC:7586 ! MYL5
+relationship: inverse_is_a HGNC:21719 ! MYL7
+relationship: inverse_is_a HGNC:15754 ! MYL9
+relationship: inverse_is_a HGNC:29824 ! MYLPF
+
+[Term]
+id: FPLX:000299
 name: MYL-slow
 synonym: "slow myosin" EXACT []
 xref: BEL:"MYL Slow Family"
-is_a: FPLX:MYL
-inverse_is_a: HGNC:MYL2
-inverse_is_a: HGNC:MYL3
-inverse_is_a: HGNC:MYL6B
+is_a: FPLX:000296 ! MYL
+relationship: inverse_is_a HGNC:7583 ! MYL2
+relationship: inverse_is_a HGNC:7584 ! MYL3
+relationship: inverse_is_a HGNC:29823 ! MYL6B
 
 [Term]
-id: FPLX:MYST
+id: FPLX:000300
 name: MYST
 synonym: "MYST family" EXACT []
 synonym: "MYST histone acetylase" EXACT []
 synonym: "MYST proteins" EXACT []
 xref: BEL:"MYST Family"
 xref: IP:IPR002717
-is_a: FPLX:root
-inverse_is_a: HGNC:KAT8
-inverse_is_a: HGNC:KAT7
-inverse_is_a: HGNC:KAT6A
-inverse_is_a: HGNC:KAT6B
-inverse_is_a: HGNC:KAT5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:17933 ! KAT8
+relationship: inverse_is_a HGNC:17016 ! KAT7
+relationship: inverse_is_a HGNC:13013 ! KAT6A
+relationship: inverse_is_a HGNC:17582 ! KAT6B
+relationship: inverse_is_a HGNC:5275 ! KAT5
 
 [Term]
-id: FPLX:NADH_dehydrogenase
+id: FPLX:000301
 name: NADH-dehydrogenase
 synonym: "NADH dehydrogenase (ubiquinone)" EXACT []
 synonym: "NADH dehydrogenase" EXACT []
 xref: BEL:"NADH Dehydrogenase Complex"
 xref: ECCODE:1.6.5.3
 xref: XFAM:PF00146
-is_a: FPLX:root
-has_part: HGNC:MT-ND1
-has_part: HGNC:MT-ND2
-has_part: HGNC:MT-ND3
-has_part: HGNC:MT-ND4
-has_part: HGNC:MT-ND4L
-has_part: HGNC:MT-ND5
-has_part: HGNC:MT-ND6
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:7455 ! MT-ND1
+relationship: has_part HGNC:7456 ! MT-ND2
+relationship: has_part HGNC:7458 ! MT-ND3
+relationship: has_part HGNC:7459 ! MT-ND4
+relationship: has_part HGNC:7460 ! MT-ND4L
+relationship: has_part HGNC:7461 ! MT-ND5
+relationship: has_part HGNC:7462 ! MT-ND6
 
 [Term]
-id: FPLX:NADPH_oxidase
+id: FPLX:000302
 name: NADPH-oxidase
 synonym: "NAD(P)H oxidase" EXACT []
 synonym: "NAD(P)H-oxidase" EXACT []
 synonym: "NADPH oxidase" EXACT []
 xref: BEL:"NADPH Oxidase Complex"
 xref: MEDSCAN:urn:agi-aopfc:0000479
-is_a: FPLX:root
-has_part: HGNC:CYBA
-has_part: HGNC:CYBB
-has_part: HGNC:DUOX1
-has_part: HGNC:DUOX2
-has_part: HGNC:NCF1
-has_part: HGNC:NCF2
-has_part: HGNC:NCF4
-has_part: HGNC:NOX1
-has_part: HGNC:NOX3
-has_part: HGNC:NOX4
-has_part: HGNC:NOX5
-has_part: HGNC:RAC1
-
-[Term]
-id: FPLX:Na_K_ATPase
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2577 ! CYBA
+relationship: has_part HGNC:2578 ! CYBB
+relationship: has_part HGNC:3062 ! DUOX1
+relationship: has_part HGNC:13273 ! DUOX2
+relationship: has_part HGNC:7660 ! NCF1
+relationship: has_part HGNC:7661 ! NCF2
+relationship: has_part HGNC:7662 ! NCF4
+relationship: has_part HGNC:7889 ! NOX1
+relationship: has_part HGNC:7890 ! NOX3
+relationship: has_part HGNC:7891 ! NOX4
+relationship: has_part HGNC:14874 ! NOX5
+relationship: has_part HGNC:9801 ! RAC1
+
+[Term]
+id: FPLX:000303
 name: Na-K-ATPase
 synonym: "Na(+),K(+)-ATPase" EXACT []
 synonym: "Na,K-ATPase" EXACT []
@@ -5138,12 +5158,12 @@ synonym: "Na+/K+ATPase" EXACT []
 synonym: "Na/K-ATPase" EXACT []
 xref: BEL:"Na/K Exchanging ATPase Complex"
 xref: ECCODE:3.6.3.9
-is_a: FPLX:root
-has_part: FPLX:ATP1A
-has_part: FPLX:ATP1B
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000057 ! ATP1A
+relationship: has_part FPLX:000058 ! ATP1B
 
 [Term]
-id: FPLX:Natriuretic_peptide
+id: FPLX:000304
 name: Natriuretic-peptide
 synonym: "Natriuretic Peptide" EXACT []
 synonym: "Natriuretic peptide" EXACT []
@@ -5151,13 +5171,13 @@ synonym: "natriuretic peptide" EXACT []
 synonym: "Natriuretic Peptides" EXACT []
 synonym: "Natriuretic peptides" EXACT []
 synonym: "natriuretic peptides" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:NPPA
-inverse_is_a: HGNC:NPPB
-inverse_is_a: HGNC:NPPC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7939 ! NPPA
+relationship: inverse_is_a HGNC:7940 ! NPPB
+relationship: inverse_is_a HGNC:7941 ! NPPC
 
 [Term]
-id: FPLX:NCOA
+id: FPLX:000305
 name: NCOA
 synonym: "p160/SRC" EXACT []
 xref: BEL:"p160/SRC Family"
@@ -5165,13 +5185,13 @@ xref: IP:IPR010011
 xref: IP:IPR014920
 xref: IP:IPR014935
 xref: IP:IPR017426
-is_a: FPLX:root
-inverse_is_a: HGNC:NCOA1
-inverse_is_a: HGNC:NCOA2
-inverse_is_a: HGNC:NCOA3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7668 ! NCOA1
+relationship: inverse_is_a HGNC:7669 ! NCOA2
+relationship: inverse_is_a HGNC:7670 ! NCOA3
 
 [Term]
-id: FPLX:NCOR
+id: FPLX:000306
 name: NCOR
 synonym: "Nuclear Receptor Co-Repressor" EXACT []
 synonym: "nuclear receptor co-repressor" EXACT []
@@ -5179,12 +5199,12 @@ synonym: "Nuclear receptor corepressor" EXACT []
 synonym: "nuclear receptor corepressor" EXACT []
 xref: BEL:"NCOR Family"
 xref: RE:R-HSA-349716
-is_a: FPLX:root
-inverse_is_a: HGNC:NCOR1
-inverse_is_a: HGNC:NCOR2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7672 ! NCOR1
+relationship: inverse_is_a HGNC:7673 ! NCOR2
 
 [Term]
-id: FPLX:NDRG
+id: FPLX:000307
 name: NDRG
 synonym: "N-myc downstream regulated gene family" EXACT []
 synonym: "NDR family" EXACT []
@@ -5192,52 +5212,52 @@ synonym: "NDR-family" EXACT []
 xref: BEL:"NDRG Family"
 xref: IP:IPR004142
 xref: XFAM:PF03096
-is_a: FPLX:root
-inverse_is_a: HGNC:NDRG1
-inverse_is_a: HGNC:NDRG2
-inverse_is_a: HGNC:NDRG3
-inverse_is_a: HGNC:NDRG4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7679 ! NDRG1
+relationship: inverse_is_a HGNC:14460 ! NDRG2
+relationship: inverse_is_a HGNC:14462 ! NDRG3
+relationship: inverse_is_a HGNC:14466 ! NDRG4
 
 [Term]
-id: FPLX:Neurexins
+id: FPLX:000308
 name: Neurexins
 synonym: "Neurexins" EXACT []
 synonym: "NRXN" EXACT []
 xref: GFAM:1582
-is_a: FPLX:root
-inverse_is_a: HGNC:NRXN1
-inverse_is_a: HGNC:NRXN2
-inverse_is_a: HGNC:NRXN3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8008 ! NRXN1
+relationship: inverse_is_a HGNC:8009 ! NRXN2
+relationship: inverse_is_a HGNC:8010 ! NRXN3
 
 [Term]
-id: FPLX:NFAT
+id: FPLX:000309
 name: NFAT
 synonym: "NFAT" EXACT []
 xref: BEL:"NFAT Family"
 xref: IP:IPR008366
 xref: NCIT:C17903
-is_a: FPLX:root
-inverse_is_a: HGNC:NFATC1
-inverse_is_a: HGNC:NFATC2
-inverse_is_a: HGNC:NFATC3
-inverse_is_a: HGNC:NFATC4
-inverse_is_a: HGNC:NFAT5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7775 ! NFATC1
+relationship: inverse_is_a HGNC:7776 ! NFATC2
+relationship: inverse_is_a HGNC:7777 ! NFATC3
+relationship: inverse_is_a HGNC:7778 ! NFATC4
+relationship: inverse_is_a HGNC:7774 ! NFAT5
 
 [Term]
-id: FPLX:NFE
+id: FPLX:000310
 name: NFE
 synonym: "NF-E2" EXACT []
 synonym: "NF-E2-related factor" EXACT []
 synonym: "Nuclear factor erythroid 2-related factor" EXACT []
 xref: MEDSCAN:urn:agi-aopfc:0000150
 xref: MEDSCAN:urn:agi-complex:NF-E2
-is_a: FPLX:root
-inverse_is_a: HGNC:NFE2L1
-inverse_is_a: HGNC:NFE2L2
-inverse_is_a: HGNC:NFE2L3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7781 ! NFE2L1
+relationship: inverse_is_a HGNC:7782 ! NFE2L2
+relationship: inverse_is_a HGNC:7783 ! NFE2L3
 
 [Term]
-id: FPLX:NFkappaB
+id: FPLX:000311
 name: NFkappaB
 synonym: "NF-kappaB complexes" EXACT []
 synonym: "NF-kappaB dimers" EXACT []
@@ -5272,12 +5292,12 @@ xref: MEDSCAN:urn:agi-aopfc:0000156
 xref: MEDSCAN:urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa
 xref: NCIT:C17380
 xref: SIGNOR:SIGNOR-PF12
-is_a: FPLX:root
-has_part: FPLX:NFkappaB_1
-has_part: FPLX:NFkappaB_2
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000312 ! NFkappaB_1
+relationship: has_part FPLX:000313 ! NFkappaB_2
 
 [Term]
-id: FPLX:NFkappaB_1
+id: FPLX:000312
 name: NFkappaB-1
 synonym: "Class 1 NF-kappaBs" EXACT []
 synonym: "class 1 NF-kappaBs" EXACT []
@@ -5297,12 +5317,12 @@ synonym: "NF-κB Class I" EXACT []
 synonym: "NF-κB class I" EXACT []
 xref: RE:R-HSA-177656
 xref: RE:R-HSA-177662
-part_of: FPLX:NFkappaB
-inverse_is_a: HGNC:NFKB1
-inverse_is_a: HGNC:NFKB2
+relationship: part_of FPLX:000311 ! NFkappaB
+relationship: inverse_is_a HGNC:7794 ! NFKB1
+relationship: inverse_is_a HGNC:7795 ! NFKB2
 
 [Term]
-id: FPLX:NFkappaB_2
+id: FPLX:000313
 name: NFkappaB-2
 synonym: "Class 2 NF-kappaBs" EXACT []
 synonym: "class 2 NF-kappaBs" EXACT []
@@ -5320,13 +5340,13 @@ synonym: "NF-κB Class 2" EXACT []
 synonym: "NF-κB class 2" EXACT []
 synonym: "NF-κB Class II" EXACT []
 synonym: "NF-κB class II" EXACT []
-part_of: FPLX:NFkappaB
-inverse_is_a: HGNC:RELA
-inverse_is_a: HGNC:RELB
-inverse_is_a: HGNC:REL
+relationship: part_of FPLX:000311 ! NFkappaB
+relationship: inverse_is_a HGNC:9955 ! RELA
+relationship: inverse_is_a HGNC:9956 ! RELB
+relationship: inverse_is_a HGNC:9954 ! REL
 
 [Term]
-id: FPLX:NFY
+id: FPLX:000314
 name: NFY
 synonym: "NF-Y" EXACT []
 synonym: "NFY" EXACT []
@@ -5335,22 +5355,22 @@ synonym: "nuclear factor-Y" EXACT []
 xref: BEL:"Nfy Complex"
 xref: RE:R-HSA-2426131
 xref: RE:R-HSA-381204
-is_a: FPLX:root
-has_part: HGNC:NFYA
-has_part: HGNC:NFYB
-has_part: HGNC:NFYC
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:7804 ! NFYA
+relationship: has_part HGNC:7805 ! NFYB
+relationship: has_part HGNC:7806 ! NFYC
 
 [Term]
-id: FPLX:NKD
+id: FPLX:000315
 name: NKD
 synonym: "naked cuticle" EXACT []
 xref: BEL:"NKD Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:NKD1
-inverse_is_a: HGNC:NKD2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:17045 ! NKD1
+relationship: inverse_is_a HGNC:17046 ! NKD2
 
 [Term]
-id: FPLX:NOS
+id: FPLX:000316
 name: NOS
 synonym: "NOS" EXACT []
 xref: BEL:"NOS Family"
@@ -5359,13 +5379,13 @@ xref: IP:IPR012144
 xref: MEDSCAN:urn:agi-aopfc:0000494
 xref: NEXTPROT-FAMILY:02504
 xref: RE:R-HSA-419294
-is_a: FPLX:root
-inverse_is_a: HGNC:NOS1
-inverse_is_a: HGNC:NOS2
-inverse_is_a: HGNC:NOS3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7872 ! NOS1
+relationship: inverse_is_a HGNC:7873 ! NOS2
+relationship: inverse_is_a HGNC:7876 ! NOS3
 
 [Term]
-id: FPLX:Notch
+id: FPLX:000317
 name: Notch
 synonym: "Notch" EXACT []
 xref: BEL:"NOTCH Family"
@@ -5382,14 +5402,14 @@ xref: RE:R-HSA-1911547
 xref: RE:R-HSA-1911550
 xref: RE:R-HSA-212420
 xref: SIGNOR:SIGNOR-PF30
-is_a: FPLX:root
-inverse_is_a: HGNC:NOTCH1
-inverse_is_a: HGNC:NOTCH2
-inverse_is_a: HGNC:NOTCH3
-inverse_is_a: HGNC:NOTCH4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7881 ! NOTCH1
+relationship: inverse_is_a HGNC:7882 ! NOTCH2
+relationship: inverse_is_a HGNC:7883 ! NOTCH3
+relationship: inverse_is_a HGNC:7884 ! NOTCH4
 
 [Term]
-id: FPLX:NRG
+id: FPLX:000318
 name: NRG
 synonym: "neuregulin family" EXACT []
 synonym: "Neuregulin" EXACT []
@@ -5400,12 +5420,12 @@ synonym: "NRGs" EXACT []
 xref: MEDSCAN:urn:agi-protfc:neuregulin%20family
 xref: XFAM:PF02158
 xref: RE:R-HSA-1227957
-is_a: FPLX:root
-inverse_is_a: FPLX:NRG_1_2
-inverse_is_a: FPLX:NRG_3_4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000319 ! NRG_1_2
+relationship: inverse_is_a FPLX:000320 ! NRG_3_4
 
 [Term]
-id: FPLX:NRG_1_2
+id: FPLX:000319
 name: NRG-1-2
 synonym: "NRG1-NRG2" EXACT []
 synonym: "NRG1/2" EXACT []
@@ -5413,22 +5433,22 @@ xref: BEL:"NRG1/2 Family"
 xref: RE:R-HSA-1227956
 xref: RE:R-HSA-1247495
 xref: RE:R-HSA-1248743
-is_a: FPLX:NRG
-inverse_is_a: HGNC:NRG1
-inverse_is_a: HGNC:NRG2
+is_a: FPLX:000318 ! NRG
+relationship: inverse_is_a HGNC:7997 ! NRG1
+relationship: inverse_is_a HGNC:7998 ! NRG2
 
 [Term]
-id: FPLX:NRG_3_4
+id: FPLX:000320
 name: NRG-3-4
 synonym: "NRG3-NRG4" EXACT []
 synonym: "NRG3/4" EXACT []
 xref: BEL:"NRG3/4 Family"
-is_a: FPLX:NRG
-inverse_is_a: HGNC:NRG3
-inverse_is_a: HGNC:NRG4
+is_a: FPLX:000318 ! NRG
+relationship: inverse_is_a HGNC:7999 ! NRG3
+relationship: inverse_is_a HGNC:29862 ! NRG4
 
 [Term]
-id: FPLX:NTRK
+id: FPLX:000321
 name: NTRK
 synonym: "NTRK" EXACT []
 synonym: "NTRKs" EXACT []
@@ -5440,22 +5460,22 @@ xref: BEL:"NTRK Family"
 xref: IP:IPR020777
 xref: IP:IPR031635
 xref: MEDSCAN:urn:agi-aopfc:0000278
-is_a: FPLX:root
-inverse_is_a: HGNC:NTRK1
-inverse_is_a: HGNC:NTRK2
-inverse_is_a: HGNC:NTRK3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8031 ! NTRK1
+relationship: inverse_is_a HGNC:8032 ! NTRK2
+relationship: inverse_is_a HGNC:8033 ! NTRK3
 
 [Term]
-id: FPLX:OGT_family
+id: FPLX:000322
 name: OGT-family
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:EOGT
-inverse_is_a: HGNC:OGT
-inverse_is_a: HGNC:POMGNT1
-inverse_is_a: HGNC:POMGNT2
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:28526 ! EOGT
+relationship: inverse_is_a HGNC:8127 ! OGT
+relationship: inverse_is_a HGNC:19139 ! POMGNT1
+relationship: inverse_is_a HGNC:25902 ! POMGNT2
 
 [Term]
-id: FPLX:p14_3_3
+id: FPLX:000323
 name: p14-3-3
 synonym: "14-3-3 proteins" EXACT []
 synonym: "14-3-3" EXACT []
@@ -5468,17 +5488,17 @@ xref: XFAM:PF00244
 xref: RE:R-HSA-1445138
 xref: RE:R-HSA-2457842
 xref: SIGNOR:SIGNOR-PF7
-is_a: FPLX:root
-inverse_is_a: HGNC:SFN
-inverse_is_a: HGNC:YWHAB
-inverse_is_a: HGNC:YWHAE
-inverse_is_a: HGNC:YWHAG
-inverse_is_a: HGNC:YWHAH
-inverse_is_a: HGNC:YWHAQ
-inverse_is_a: HGNC:YWHAZ
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10773 ! SFN
+relationship: inverse_is_a HGNC:12849 ! YWHAB
+relationship: inverse_is_a HGNC:12851 ! YWHAE
+relationship: inverse_is_a HGNC:12852 ! YWHAG
+relationship: inverse_is_a HGNC:12853 ! YWHAH
+relationship: inverse_is_a HGNC:12854 ! YWHAQ
+relationship: inverse_is_a HGNC:12855 ! YWHAZ
 
 [Term]
-id: FPLX:P2RX
+id: FPLX:000324
 name: P2RX
 synonym: "P2X purinoreceptor" EXACT []
 synonym: "P2X purinoreceptors" EXACT []
@@ -5493,37 +5513,37 @@ xref: NEXTPROT-FAMILY:02630
 xref: XFAM:PF00864
 xref: RE:R-HSA-139848
 xref: RE:R-HSA-8861873
-is_a: FPLX:root
-inverse_is_a: HGNC:P2RX1
-inverse_is_a: HGNC:P2RX2
-inverse_is_a: HGNC:P2RX3
-inverse_is_a: HGNC:P2RX4
-inverse_is_a: HGNC:P2RX5
-inverse_is_a: HGNC:P2RX6
-inverse_is_a: HGNC:P2RX7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8533 ! P2RX1
+relationship: inverse_is_a HGNC:15459 ! P2RX2
+relationship: inverse_is_a HGNC:8534 ! P2RX3
+relationship: inverse_is_a HGNC:8535 ! P2RX4
+relationship: inverse_is_a HGNC:8536 ! P2RX5
+relationship: inverse_is_a HGNC:8538 ! P2RX6
+relationship: inverse_is_a HGNC:8537 ! P2RX7
 
 [Term]
-id: FPLX:P2RY
+id: FPLX:000325
 name: P2RY
 synonym: "P2Y receptor" EXACT []
 xref: BEL:"P2RY Family"
 xref: MEDSCAN:urn:agi-protfc:p2y%20receptor
-is_a: FPLX:root
-inverse_is_a: HGNC:P2RY1
-inverse_is_a: HGNC:P2RY2
-inverse_is_a: HGNC:P2RY4
-inverse_is_a: HGNC:P2RY6
-inverse_is_a: HGNC:P2RY8
-inverse_is_a: HGNC:P2RY10
-inverse_is_a: HGNC:P2RY11
-inverse_is_a: HGNC:P2RY12
-inverse_is_a: HGNC:P2RY13
-inverse_is_a: HGNC:P2RY14
-inverse_is_a: HGNC:LPAR4
-inverse_is_a: HGNC:LPAR6
-
-[Term]
-id: FPLX:p38
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8539 ! P2RY1
+relationship: inverse_is_a HGNC:8541 ! P2RY2
+relationship: inverse_is_a HGNC:8542 ! P2RY4
+relationship: inverse_is_a HGNC:8543 ! P2RY6
+relationship: inverse_is_a HGNC:15524 ! P2RY8
+relationship: inverse_is_a HGNC:19906 ! P2RY10
+relationship: inverse_is_a HGNC:8540 ! P2RY11
+relationship: inverse_is_a HGNC:18124 ! P2RY12
+relationship: inverse_is_a HGNC:4537 ! P2RY13
+relationship: inverse_is_a HGNC:16442 ! P2RY14
+relationship: inverse_is_a HGNC:4478 ! LPAR4
+relationship: inverse_is_a HGNC:15520 ! LPAR6
+
+[Term]
+id: FPLX:000326
 name: p38
 synonym: "MAPK p38" EXACT []
 synonym: "P38 MAPK" EXACT []
@@ -5540,14 +5560,14 @@ xref: RE:R-HSA-1250102
 xref: RE:R-HSA-171016
 xref: RE:R-HSA-189828
 xref: SIGNOR:SIGNOR-PF16
-is_a: FPLX:MAPK
-inverse_is_a: HGNC:MAPK11
-inverse_is_a: HGNC:MAPK12
-inverse_is_a: HGNC:MAPK13
-inverse_is_a: HGNC:MAPK14
+is_a: FPLX:000283 ! MAPK
+relationship: inverse_is_a HGNC:6873 ! MAPK11
+relationship: inverse_is_a HGNC:6874 ! MAPK12
+relationship: inverse_is_a HGNC:6875 ! MAPK13
+relationship: inverse_is_a HGNC:6876 ! MAPK14
 
 [Term]
-id: FPLX:p53_family
+id: FPLX:000327
 name: p53-family
 synonym: "P53 family" EXACT []
 synonym: "p53 Family" EXACT []
@@ -5560,13 +5580,13 @@ xref: NEXTPROT-FAMILY:02632
 xref: XFAM:PF00870
 xref: RE:R-HSA-6798076
 xref: RE:R-HSA-6798078
-is_a: FPLX:root
-inverse_is_a: HGNC:TP53
-inverse_is_a: HGNC:TP63
-inverse_is_a: HGNC:TP73
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11998 ! TP53
+relationship: inverse_is_a HGNC:15979 ! TP63
+relationship: inverse_is_a HGNC:12003 ! TP73
 
 [Term]
-id: FPLX:P70S6K
+id: FPLX:000328
 name: P70S6K
 synonym: "p70 S6 kinase" EXACT []
 synonym: "P70RSK" EXACT []
@@ -5575,12 +5595,12 @@ synonym: "P70S6K" EXACT []
 synonym: "S6K" EXACT []
 xref: BEL:"RPS6KB Family"
 xref: MEDSCAN:urn:agi-protfc:p70rsk
-is_a: FPLX:RSK
-inverse_is_a: HGNC:RPS6KB1
-inverse_is_a: HGNC:RPS6KB2
+is_a: FPLX:000422 ! RSK
+relationship: inverse_is_a HGNC:10436 ! RPS6KB1
+relationship: inverse_is_a HGNC:10437 ! RPS6KB2
 
 [Term]
-id: FPLX:P90RSK
+id: FPLX:000329
 name: P90RSK
 synonym: "p90RSK" EXACT []
 synonym: "RPS6KA" EXACT []
@@ -5589,16 +5609,16 @@ xref: IP:IPR016239
 xref: MEDSCAN:urn:agi-protfc:p90rsk
 xref: RE:R-HSA-446849
 xref: SIGNOR:SIGNOR-PF26
-is_a: FPLX:RSK
-inverse_is_a: HGNC:RPS6KA1
-inverse_is_a: HGNC:RPS6KA2
-inverse_is_a: HGNC:RPS6KA3
-inverse_is_a: HGNC:RPS6KA4
-inverse_is_a: HGNC:RPS6KA5
-inverse_is_a: HGNC:RPS6KA6
+is_a: FPLX:000422 ! RSK
+relationship: inverse_is_a HGNC:10430 ! RPS6KA1
+relationship: inverse_is_a HGNC:10431 ! RPS6KA2
+relationship: inverse_is_a HGNC:10432 ! RPS6KA3
+relationship: inverse_is_a HGNC:10433 ! RPS6KA4
+relationship: inverse_is_a HGNC:10434 ! RPS6KA5
+relationship: inverse_is_a HGNC:10435 ! RPS6KA6
 
 [Term]
-id: FPLX:PAK
+id: FPLX:000330
 name: PAK
 synonym: "PAK" EXACT []
 synonym: "Pak" EXACT []
@@ -5607,42 +5627,42 @@ xref: IP:IPR033923
 xref: MEDSCAN:urn:agi-aopfc:0000468
 xref: RE:R-HSA-428475
 xref: SIGNOR:SIGNOR-PF13
-is_a: FPLX:root
-inverse_is_a: HGNC:PAK1
-inverse_is_a: HGNC:PAK2
-inverse_is_a: HGNC:PAK3
-inverse_is_a: HGNC:PAK4
-inverse_is_a: HGNC:PAK5
-inverse_is_a: HGNC:PAK6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8590 ! PAK1
+relationship: inverse_is_a HGNC:8591 ! PAK2
+relationship: inverse_is_a HGNC:8592 ! PAK3
+relationship: inverse_is_a HGNC:16059 ! PAK4
+relationship: inverse_is_a HGNC:15916 ! PAK5
+relationship: inverse_is_a HGNC:16061 ! PAK6
 
 [Term]
-id: FPLX:PARP
+id: FPLX:000331
 name: PARP
 synonym: "PARP genes" EXACT []
 synonym: "PARPs" EXACT []
 synonym: "Poly(ADP-ribose) polymerase" EXACT []
 synonym: "Poly(ADP-ribose) polymerases" EXACT []
 xref: XFAM:PF00644
-is_a: FPLX:root
-inverse_is_a: HGNC:PARP1
-inverse_is_a: HGNC:PARP2
-inverse_is_a: HGNC:PARP3
-inverse_is_a: HGNC:PARP4
-inverse_is_a: HGNC:PARP6
-inverse_is_a: HGNC:PARP8
-inverse_is_a: HGNC:PARP9
-inverse_is_a: HGNC:PARP10
-inverse_is_a: HGNC:PARP11
-inverse_is_a: HGNC:PARP12
-inverse_is_a: HGNC:PARP14
-inverse_is_a: HGNC:PARP15
-inverse_is_a: HGNC:PARP16
-inverse_is_a: HGNC:TNKS
-inverse_is_a: HGNC:TNKS2
-inverse_is_a: HGNC:TIPARP
-
-[Term]
-id: FPLX:PARV
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:270 ! PARP1
+relationship: inverse_is_a HGNC:272 ! PARP2
+relationship: inverse_is_a HGNC:273 ! PARP3
+relationship: inverse_is_a HGNC:271 ! PARP4
+relationship: inverse_is_a HGNC:26921 ! PARP6
+relationship: inverse_is_a HGNC:26124 ! PARP8
+relationship: inverse_is_a HGNC:24118 ! PARP9
+relationship: inverse_is_a HGNC:25895 ! PARP10
+relationship: inverse_is_a HGNC:1186 ! PARP11
+relationship: inverse_is_a HGNC:21919 ! PARP12
+relationship: inverse_is_a HGNC:29232 ! PARP14
+relationship: inverse_is_a HGNC:26876 ! PARP15
+relationship: inverse_is_a HGNC:26040 ! PARP16
+relationship: inverse_is_a HGNC:11941 ! TNKS
+relationship: inverse_is_a HGNC:15677 ! TNKS2
+relationship: inverse_is_a HGNC:23696 ! TIPARP
+
+[Term]
+id: FPLX:000332
 name: PARV
 synonym: "Parvin" EXACT []
 synonym: "parvin" EXACT []
@@ -5651,13 +5671,13 @@ synonym: "parvins" EXACT []
 xref: BEL:"PARV Family"
 xref: IP:IPR028433
 xref: NEXTPROT-FAMILY:02660
-is_a: FPLX:root
-inverse_is_a: HGNC:PARVA
-inverse_is_a: HGNC:PARVB
-inverse_is_a: HGNC:PARVG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:14652 ! PARVA
+relationship: inverse_is_a HGNC:14653 ! PARVB
+relationship: inverse_is_a HGNC:14654 ! PARVG
 
 [Term]
-id: FPLX:Patched
+id: FPLX:000333
 name: Patched
 synonym: "PATCHED" EXACT []
 synonym: "Patched" EXACT []
@@ -5665,12 +5685,12 @@ xref: IP:IPR004766
 xref: MEDSCAN:urn:agi-aopfc:0000281
 xref: XFAM:PF02460
 xref: RE:R-HSA-445134
-is_a: FPLX:root
-inverse_is_a: HGNC:PTCH1
-inverse_is_a: HGNC:PTCH2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9585 ! PTCH1
+relationship: inverse_is_a HGNC:9586 ! PTCH2
 
 [Term]
-id: FPLX:PBX
+id: FPLX:000334
 name: PBX
 synonym: "PBX" EXACT []
 synonym: "Pbx" EXACT []
@@ -5678,14 +5698,14 @@ synonym: "pbx" EXACT []
 synonym: "PBXs" EXACT []
 xref: BEL:"PBX Family"
 xref: IP:IPR005542
-is_a: FPLX:root
-inverse_is_a: HGNC:PBX1
-inverse_is_a: HGNC:PBX2
-inverse_is_a: HGNC:PBX3
-inverse_is_a: HGNC:PBX4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8632 ! PBX1
+relationship: inverse_is_a HGNC:8633 ! PBX2
+relationship: inverse_is_a HGNC:8634 ! PBX3
+relationship: inverse_is_a HGNC:13403 ! PBX4
 
 [Term]
-id: FPLX:PDE
+id: FPLX:000335
 name: PDE
 synonym: "PDE" EXACT []
 synonym: "PDEs" EXACT []
@@ -5695,20 +5715,20 @@ synonym: "Phosphodiesterases" EXACT []
 synonym: "phosphodiesterases" EXACT []
 xref: BEL:"PDE Family"
 xref: ECCODE:3.1.4.-
-is_a: FPLX:root
-inverse_is_a: HGNC:PDE2A
-inverse_is_a: HGNC:PDE9A
-inverse_is_a: HGNC:PDE10A
-inverse_is_a: HGNC:PDE11A
-inverse_is_a: FPLX:PDE1
-inverse_is_a: FPLX:PDE3
-inverse_is_a: FPLX:PDE4
-inverse_is_a: FPLX:PDE6
-inverse_is_a: FPLX:PDE7
-inverse_is_a: FPLX:PDE8
-
-[Term]
-id: FPLX:PDE1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8777 ! PDE2A
+relationship: inverse_is_a HGNC:8795 ! PDE9A
+relationship: inverse_is_a HGNC:8772 ! PDE10A
+relationship: inverse_is_a HGNC:8773 ! PDE11A
+relationship: inverse_is_a FPLX:000336 ! PDE1
+relationship: inverse_is_a FPLX:000337 ! PDE3
+relationship: inverse_is_a FPLX:000338 ! PDE4
+relationship: inverse_is_a FPLX:000339 ! PDE6
+relationship: inverse_is_a FPLX:000340 ! PDE7
+relationship: inverse_is_a FPLX:000341 ! PDE8
+
+[Term]
+id: FPLX:000336
 name: PDE1
 synonym: "PDE1 family" EXACT []
 synonym: "PDE1" EXACT []
@@ -5721,13 +5741,13 @@ xref: GO:0004117
 xref: IP:IPR013706
 xref: RE:R-HSA-111952
 xref: RE:R-HSA-111953
-is_a: FPLX:PDE
-inverse_is_a: HGNC:PDE1A
-inverse_is_a: HGNC:PDE1B
-inverse_is_a: HGNC:PDE1C
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8774 ! PDE1A
+relationship: inverse_is_a HGNC:8775 ! PDE1B
+relationship: inverse_is_a HGNC:8776 ! PDE1C
 
 [Term]
-id: FPLX:PDE3
+id: FPLX:000337
 name: PDE3
 synonym: "PDE 3" EXACT []
 synonym: "PDE3 family" EXACT []
@@ -5739,12 +5759,12 @@ synonym: "phosphodiesterase-3" EXACT []
 xref: BEL:"PDE3 Family"
 xref: MEDSCAN:urn:agi-protfc:phosphodiesterase%20III
 xref: NEXTPROT-FAMILY:00803
-is_a: FPLX:PDE
-inverse_is_a: HGNC:PDE3A
-inverse_is_a: HGNC:PDE3B
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8778 ! PDE3A
+relationship: inverse_is_a HGNC:8779 ! PDE3B
 
 [Term]
-id: FPLX:PDE4
+id: FPLX:000338
 name: PDE4
 synonym: "PDE4 family" EXACT []
 synonym: "PDE4 isoforms" EXACT []
@@ -5759,14 +5779,14 @@ xref: MEDSCAN:urn:agi-protfc:PDE4%20subfamily
 xref: NCIT:C107433
 xref: NEXTPROT-FAMILY:00804
 xref: RE:R-HSA-111960
-is_a: FPLX:PDE
-inverse_is_a: HGNC:PDE4A
-inverse_is_a: HGNC:PDE4B
-inverse_is_a: HGNC:PDE4C
-inverse_is_a: HGNC:PDE4D
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8780 ! PDE4A
+relationship: inverse_is_a HGNC:8781 ! PDE4B
+relationship: inverse_is_a HGNC:8782 ! PDE4C
+relationship: inverse_is_a HGNC:8783 ! PDE4D
 
 [Term]
-id: FPLX:PDE6
+id: FPLX:000339
 name: PDE6
 synonym: "PDE6 family" EXACT []
 synonym: "PDE6" EXACT []
@@ -5776,13 +5796,13 @@ synonym: "Phosphodiesterase-6" EXACT []
 synonym: "phosphodiesterase-6" EXACT []
 xref: BEL:"PDE6 Family"
 xref: MEDSCAN:urn:agi-aopfc:0000704
-is_a: FPLX:PDE
-inverse_is_a: HGNC:PDE6A
-inverse_is_a: HGNC:PDE6B
-inverse_is_a: HGNC:PDE6C
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8785 ! PDE6A
+relationship: inverse_is_a HGNC:8786 ! PDE6B
+relationship: inverse_is_a HGNC:8787 ! PDE6C
 
 [Term]
-id: FPLX:PDE7
+id: FPLX:000340
 name: PDE7
 synonym: "PDE7" EXACT []
 synonym: "Phosphodiesterase 7" EXACT []
@@ -5790,12 +5810,12 @@ synonym: "phosphodiesterase 7" EXACT []
 synonym: "Phosphodiesterase-7" EXACT []
 synonym: "phosphodiesterase-7" EXACT []
 xref: RE:R-HSA-418540
-is_a: FPLX:PDE
-inverse_is_a: HGNC:PDE7A
-inverse_is_a: HGNC:PDE7B
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8791 ! PDE7A
+relationship: inverse_is_a HGNC:8792 ! PDE7B
 
 [Term]
-id: FPLX:PDE8
+id: FPLX:000341
 name: PDE8
 synonym: "PDE8" EXACT []
 synonym: "Phosphodiesterase 8" EXACT []
@@ -5803,12 +5823,12 @@ synonym: "phosphodiesterase 8" EXACT []
 synonym: "Phosphodiesterase-8" EXACT []
 synonym: "phosphodiesterase-8" EXACT []
 xref: RE:R-HSA-418541
-is_a: FPLX:PDE
-inverse_is_a: HGNC:PDE8A
-inverse_is_a: HGNC:PDE8B
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8793 ! PDE8A
+relationship: inverse_is_a HGNC:8794 ! PDE8B
 
 [Term]
-id: FPLX:PDGF
+id: FPLX:000342
 name: PDGF
 synonym: "PDGF" EXACT []
 xref: BEL:"PDGF Family"
@@ -5816,14 +5836,14 @@ xref: GO:0005161
 xref: NCIT:C20448
 xref: RE:R-HSA-381926
 xref: RE:R-HSA-381936
-is_a: FPLX:root
-inverse_is_a: HGNC:PDGFA
-inverse_is_a: HGNC:PDGFB
-inverse_is_a: HGNC:PDGFC
-inverse_is_a: HGNC:PDGFD
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8799 ! PDGFA
+relationship: inverse_is_a HGNC:8800 ! PDGFB
+relationship: inverse_is_a HGNC:8801 ! PDGFC
+relationship: inverse_is_a HGNC:30620 ! PDGFD
 
 [Term]
-id: FPLX:PDGFR
+id: FPLX:000343
 name: PDGFR
 synonym: "PDGFR" EXACT []
 xref: BEL:"PDGFR Family"
@@ -5834,12 +5854,12 @@ xref: RE:R-HSA-186791
 xref: RE:R-HSA-186792
 xref: RE:R-HSA-186821
 xref: RE:R-HSA-8864040
-is_a: FPLX:root
-inverse_is_a: HGNC:PDGFRA
-inverse_is_a: HGNC:PDGFRB
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8803 ! PDGFRA
+relationship: inverse_is_a HGNC:8804 ! PDGFRB
 
 [Term]
-id: FPLX:PDGFR_AA
+id: FPLX:000344
 name: PDGFR-AA
 synonym: "PDGFR-AA" EXACT []
 synonym: "PDGFR-alphaalpha" EXACT []
@@ -5849,11 +5869,11 @@ synonym: "PDGFRαα" EXACT []
 xref: IP:IPR027290
 xref: RE:R-HSA-186816
 xref: RE:R-HSA-186817
-is_a: FPLX:root
-has_part: HGNC:PDGFRA
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8803 ! PDGFRA
 
 [Term]
-id: FPLX:PDGFR_AB
+id: FPLX:000345
 name: PDGFR-AB
 synonym: "PDGFR-AB" EXACT []
 synonym: "PDGFR-alphabeta" EXACT []
@@ -5866,12 +5886,12 @@ xref: RE:R-HSA-186791
 xref: RE:R-HSA-186792
 xref: RE:R-HSA-186821
 xref: RE:R-HSA-8864040
-is_a: FPLX:root
-has_part: HGNC:PDGFRA
-has_part: HGNC:PDGFRB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8803 ! PDGFRA
+relationship: has_part HGNC:8804 ! PDGFRB
 
 [Term]
-id: FPLX:PDGFR_BB
+id: FPLX:000346
 name: PDGFR-BB
 synonym: "PDGFR-BB" EXACT []
 synonym: "PDGFR-betabeta" EXACT []
@@ -5882,34 +5902,34 @@ xref: IP:IPR027288
 xref: RE:R-HSA-186799
 xref: RE:R-HSA-186805
 xref: RE:R-HSA-8864046
-is_a: FPLX:root
-has_part: HGNC:PDGFRB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8804 ! PDGFRB
 
 [Term]
-id: FPLX:PDGF_AA
+id: FPLX:000347
 name: PDGF-AA
 synonym: "PDGF-AA" EXACT []
 synonym: "PDGF-aa" EXACT []
 synonym: "PDGFAA" EXACT []
 xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AA
 xref: RE:R-HSA-184203
-is_a: FPLX:root
-has_part: HGNC:PDGFA
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8799 ! PDGFA
 
 [Term]
-id: FPLX:PDGF_AB
+id: FPLX:000348
 name: PDGF-AB
 synonym: "PDGF-AB" EXACT []
 synonym: "PDGF-ab" EXACT []
 synonym: "PDGFAB" EXACT []
 xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AB
 xref: RE:R-HSA-380759
-is_a: FPLX:root
-has_part: HGNC:PDGFA
-has_part: HGNC:PDGFB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8799 ! PDGFA
+relationship: has_part HGNC:8800 ! PDGFB
 
 [Term]
-id: FPLX:PDGF_BB
+id: FPLX:000349
 name: PDGF-BB
 synonym: "PDGF-BB" EXACT []
 synonym: "PDGF-bb" EXACT []
@@ -5929,45 +5949,45 @@ xref: RE:R-HSA-381935
 xref: RE:R-HSA-381938
 xref: RE:R-HSA-387074
 xref: RE:R-HSA-392712
-is_a: FPLX:root
-has_part: HGNC:PDGFB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8800 ! PDGFB
 
 [Term]
-id: FPLX:PDGF_CC
+id: FPLX:000350
 name: PDGF-CC
 synonym: "PDGF CC" EXACT []
 synonym: "PDGF-CC" EXACT []
 synonym: "PDGF-cc" EXACT []
 xref: RE:R-HSA-381941
-is_a: FPLX:root
-has_part: HGNC:PDGFC
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8801 ! PDGFC
 
 [Term]
-id: FPLX:PDGF_DD
+id: FPLX:000351
 name: PDGF-DD
 synonym: "PDGF DD" EXACT []
 synonym: "PDGF-DD" EXACT []
 synonym: "PDGF-dd" EXACT []
 xref: RE:R-HSA-381930
-is_a: FPLX:root
-has_part: HGNC:PDGFD
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:30620 ! PDGFD
 
 [Term]
-id: FPLX:PDH
+id: FPLX:000352
 name: PDH
 synonym: "PDH" EXACT []
 synonym: "pyruvate dehydrogenase (acetyl-transferring)" EXACT []
 xref: BEL:"Pyruvate Dehydrogenase Complex"
-is_a: FPLX:root
-has_part: HGNC:DLAT
-has_part: HGNC:DLD
-has_part: HGNC:PDHA1
-has_part: HGNC:PDHA2
-has_part: HGNC:PDHB
-has_part: HGNC:PDHX
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2896 ! DLAT
+relationship: has_part HGNC:2898 ! DLD
+relationship: has_part HGNC:8806 ! PDHA1
+relationship: has_part HGNC:8807 ! PDHA2
+relationship: has_part HGNC:8808 ! PDHB
+relationship: has_part HGNC:21350 ! PDHX
 
 [Term]
-id: FPLX:PDK
+id: FPLX:000353
 name: PDK
 synonym: "PDK" EXACT []
 synonym: "PDKs" EXACT []
@@ -5976,23 +5996,23 @@ synonym: "pyruvate dehydrogenase kinase" EXACT []
 xref: BEL:"PDK Family"
 xref: ECCODE:1.2.4.1
 xref: RE:R-HSA-203947
-is_a: FPLX:root
-inverse_is_a: HGNC:PDK1
-inverse_is_a: HGNC:PDK2
-inverse_is_a: HGNC:PDK3
-inverse_is_a: HGNC:PDK4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8809 ! PDK1
+relationship: inverse_is_a HGNC:8810 ! PDK2
+relationship: inverse_is_a HGNC:8811 ! PDK3
+relationship: inverse_is_a HGNC:8812 ! PDK4
 
 [Term]
-id: FPLX:Pertussis_toxin
+id: FPLX:000354
 name: Pertussis-toxin
 synonym: "Pertussis toxin" EXACT []
 synonym: "pertussis toxin" EXACT []
 synonym: "PTX" EXACT []
 xref: NCIT:C736
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:PFN
+id: FPLX:000355
 name: PFN
 synonym: "Profilin" EXACT []
 synonym: "profilin" EXACT []
@@ -6002,38 +6022,38 @@ xref: BEL:"PFN Family"
 xref: IP:IPR005455
 xref: MEDSCAN:urn:agi-protfc:profilin
 xref: XFAM:PF00235
-is_a: FPLX:root
-inverse_is_a: HGNC:PFN1
-inverse_is_a: HGNC:PFN2
-inverse_is_a: HGNC:PFN3
-inverse_is_a: HGNC:PFN4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8881 ! PFN1
+relationship: inverse_is_a HGNC:8882 ! PFN2
+relationship: inverse_is_a HGNC:18627 ! PFN3
+relationship: inverse_is_a HGNC:31103 ! PFN4
 
 [Term]
-id: FPLX:PhK
+id: FPLX:000356
 name: PhK
 synonym: "PhK" EXACT []
 synonym: "Phosphorylase kinase" EXACT []
 synonym: "phosphorylase kinase" EXACT []
 xref: BEL:"Phosphorylase B Kinase Complex"
 xref: ECCODE:2.7.11.19
-is_a: FPLX:root
-has_part: HGNC:CALM1
-has_part: HGNC:PHKA1
-has_part: HGNC:PHKA2
-has_part: HGNC:PHKB
-has_part: HGNC:PHKG1
-has_part: HGNC:PHKG2
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1442 ! CALM1
+relationship: has_part HGNC:8925 ! PHKA1
+relationship: has_part HGNC:8926 ! PHKA2
+relationship: has_part HGNC:8927 ! PHKB
+relationship: has_part HGNC:8930 ! PHKG1
+relationship: has_part HGNC:8931 ! PHKG2
 
 [Term]
-id: FPLX:Phosphatase
+id: FPLX:000357
 name: Phosphatase
 synonym: "phosphatase" EXACT []
 xref: MESH:D010749
 xref: NCIT:C16981
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:PI3K
+id: FPLX:000358
 name: PI3K
 synonym: "phosphatidylinositol 3-kinase" EXACT []
 synonym: "PI 3-kinase" EXACT []
@@ -6045,59 +6065,59 @@ xref: BEL:"p85/p110 PI3Kinase Complex"
 xref: MEDSCAN:urn:agi-aopfc:0000447
 xref: MEDSCAN:urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa
 xref: NCIT:C17270
-is_a: FPLX:root
-has_part: FPLX:PI3K_p110
-has_part: FPLX:PIK3R_I
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000359 ! PI3K_p110
+relationship: has_part FPLX:000361 ! PIK3R_I
 
 [Term]
-id: FPLX:PI3K_p110
+id: FPLX:000359
 name: PI3K-p110
 synonym: "p110" EXACT []
 synonym: "PI3K p110 subunit" EXACT []
 synonym: "PIK3C" EXACT []
 xref: BEL:"PIK3C Class IA Family"
 xref: IP:IPR003113
-part_of: FPLX:PI3K
-inverse_is_a: HGNC:PIK3CA
-inverse_is_a: HGNC:PIK3CB
-inverse_is_a: HGNC:PIK3CD
-inverse_is_a: HGNC:PIK3CG
+relationship: part_of FPLX:000358 ! PI3K
+relationship: inverse_is_a HGNC:8975 ! PIK3CA
+relationship: inverse_is_a HGNC:8976 ! PIK3CB
+relationship: inverse_is_a HGNC:8977 ! PIK3CD
+relationship: inverse_is_a HGNC:8978 ! PIK3CG
 
 [Term]
-id: FPLX:PI3K_p85
+id: FPLX:000360
 name: PI3K-p85
 synonym: "p85" EXACT []
 xref: RE:R-HSA-74688
-is_a: FPLX:PIK3R_I
-inverse_is_a: HGNC:PIK3R1
-inverse_is_a: HGNC:PIK3R2
+is_a: FPLX:000361 ! PIK3R_I
+relationship: inverse_is_a HGNC:8979 ! PIK3R1
+relationship: inverse_is_a HGNC:8980 ! PIK3R2
 
 [Term]
-id: FPLX:PIK3R_I
+id: FPLX:000361
 name: PIK3R-I
 synonym: "PIK3R" EXACT []
 xref: BEL:"PIK3R Class IA Family"
-part_of: FPLX:PI3K
-inverse_is_a: HGNC:PIK3R3
-inverse_is_a: HGNC:PIK3R4
-inverse_is_a: HGNC:PIK3R5
-inverse_is_a: HGNC:PIK3R6
-inverse_is_a: FPLX:PI3K_p85
+relationship: part_of FPLX:000358 ! PI3K
+relationship: inverse_is_a HGNC:8981 ! PIK3R3
+relationship: inverse_is_a HGNC:8982 ! PIK3R4
+relationship: inverse_is_a HGNC:30035 ! PIK3R5
+relationship: inverse_is_a HGNC:27101 ! PIK3R6
+relationship: inverse_is_a FPLX:000360 ! PI3K_p85
 
 [Term]
-id: FPLX:PIM
+id: FPLX:000362
 name: PIM
 synonym: "PIM" EXACT []
 xref: IP:IPR017348
 xref: NEXTPROT-FAMILY:03078
 xref: SIGNOR:SIGNOR-PF34
-is_a: FPLX:root
-inverse_is_a: HGNC:PIM1
-inverse_is_a: HGNC:PIM2
-inverse_is_a: HGNC:PIM3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8986 ! PIM1
+relationship: inverse_is_a HGNC:8987 ! PIM2
+relationship: inverse_is_a HGNC:19310 ! PIM3
 
 [Term]
-id: FPLX:PKA
+id: FPLX:000363
 name: PKA
 synonym: "cAMP-dependent PK" EXACT []
 synonym: "cAMP-dependent protein kinase" EXACT []
@@ -6108,12 +6128,12 @@ synonym: "PKA" EXACT []
 synonym: "protein kinase A" EXACT []
 xref: ECCODE:2.7.11.11
 xref: NCIT:C16479
-is_a: FPLX:root
-has_part: FPLX:PRKAR
-has_part: FPLX:PRKAC
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000390 ! PRKAR
+relationship: has_part FPLX:000389 ! PRKAC
 
 [Term]
-id: FPLX:PKC
+id: FPLX:000364
 name: PKC
 synonym: "PKC" EXACT []
 synonym: "protein kinase C" EXACT []
@@ -6123,32 +6143,32 @@ xref: IP:IPR012233
 xref: MESH:D011493
 xref: NCIT:C17017
 xref: NEXTPROT-FAMILY:03065
-is_a: FPLX:root
-inverse_is_a: HGNC:PRKCA
-inverse_is_a: HGNC:PRKCB
-inverse_is_a: HGNC:PRKCD
-inverse_is_a: HGNC:PRKCE
-inverse_is_a: HGNC:PRKCG
-inverse_is_a: HGNC:PRKCH
-inverse_is_a: HGNC:PRKCI
-inverse_is_a: HGNC:PRKCQ
-inverse_is_a: HGNC:PRKCZ
-inverse_is_a: HGNC:PRKD3
-
-[Term]
-id: FPLX:PKI
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9393 ! PRKCA
+relationship: inverse_is_a HGNC:9395 ! PRKCB
+relationship: inverse_is_a HGNC:9399 ! PRKCD
+relationship: inverse_is_a HGNC:9401 ! PRKCE
+relationship: inverse_is_a HGNC:9402 ! PRKCG
+relationship: inverse_is_a HGNC:9403 ! PRKCH
+relationship: inverse_is_a HGNC:9404 ! PRKCI
+relationship: inverse_is_a HGNC:9410 ! PRKCQ
+relationship: inverse_is_a HGNC:9412 ! PRKCZ
+relationship: inverse_is_a HGNC:9408 ! PRKD3
+
+[Term]
+id: FPLX:000365
 name: PKI
 synonym: "PKI" EXACT []
 xref: BEL:"PKI Family"
 xref: IP:IPR004171
 xref: XFAM:PF02827
-is_a: FPLX:root
-inverse_is_a: HGNC:PKIA
-inverse_is_a: HGNC:PKIB
-inverse_is_a: HGNC:PKIG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9017 ! PKIA
+relationship: inverse_is_a HGNC:9018 ! PKIB
+relationship: inverse_is_a HGNC:9019 ! PKIG
 
 [Term]
-id: FPLX:PLA2
+id: FPLX:000366
 name: PLA2
 synonym: "cPLA2" EXACT []
 synonym: "cytosolic phospholipase A(2)" EXACT []
@@ -6161,20 +6181,20 @@ xref: MEDSCAN:urn:agi-aopfc:0000455
 xref: MEDSCAN:urn:agi-protfc:cytosolic%20phospholipase%20a2
 xref: NCIT:C16979
 xref: NEXTPROT-FAMILY:02840
-is_a: FPLX:root
-inverse_is_a: HGNC:PLA2G1B
-inverse_is_a: HGNC:PLA2G3
-inverse_is_a: HGNC:PLA2G5
-inverse_is_a: HGNC:PLA2G6
-inverse_is_a: HGNC:PLA2G7
-inverse_is_a: HGNC:PLA2G10
-inverse_is_a: HGNC:PLA2G12A
-inverse_is_a: HGNC:PLA2G12B
-inverse_is_a: FPLX:PLA2G2
-inverse_is_a: FPLX:PLA2G4
-
-[Term]
-id: FPLX:PLA2G2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9030 ! PLA2G1B
+relationship: inverse_is_a HGNC:17934 ! PLA2G3
+relationship: inverse_is_a HGNC:9038 ! PLA2G5
+relationship: inverse_is_a HGNC:9039 ! PLA2G6
+relationship: inverse_is_a HGNC:9040 ! PLA2G7
+relationship: inverse_is_a HGNC:9029 ! PLA2G10
+relationship: inverse_is_a HGNC:18554 ! PLA2G12A
+relationship: inverse_is_a HGNC:18555 ! PLA2G12B
+relationship: inverse_is_a FPLX:000367 ! PLA2G2
+relationship: inverse_is_a FPLX:000368 ! PLA2G4
+
+[Term]
+id: FPLX:000367
 name: PLA2G2
 synonym: "GII PLA2" EXACT []
 synonym: "GIIPLA2" EXACT []
@@ -6182,15 +6202,15 @@ synonym: "phospholipase A2 group-II" EXACT []
 synonym: "PLA2G2" EXACT []
 synonym: "PLA2g2" EXACT []
 xref: BEL:"PLA2G2 Family"
-is_a: FPLX:PLA2
-inverse_is_a: HGNC:PLA2G2A
-inverse_is_a: HGNC:PLA2G2C
-inverse_is_a: HGNC:PLA2G2D
-inverse_is_a: HGNC:PLA2G2E
-inverse_is_a: HGNC:PLA2G2F
+is_a: FPLX:000366 ! PLA2
+relationship: inverse_is_a HGNC:9031 ! PLA2G2A
+relationship: inverse_is_a HGNC:9032 ! PLA2G2C
+relationship: inverse_is_a HGNC:9033 ! PLA2G2D
+relationship: inverse_is_a HGNC:13414 ! PLA2G2E
+relationship: inverse_is_a HGNC:30040 ! PLA2G2F
 
 [Term]
-id: FPLX:PLA2G4
+id: FPLX:000368
 name: PLA2G4
 synonym: "gIV-PLA(2)" EXACT []
 synonym: "group IV-PLA(2)" EXACT []
@@ -6198,13 +6218,13 @@ synonym: "Phospholipase A2 Group IV" EXACT []
 synonym: "phospholipase A2 group-IV" EXACT []
 synonym: "PLA2G4" EXACT []
 xref: NCIT:C19836
-is_a: FPLX:PLA2
-inverse_is_a: HGNC:PLA2G4A
-inverse_is_a: HGNC:PLA2G4C
-inverse_is_a: HGNC:PLA2G4D
+is_a: FPLX:000366 ! PLA2
+relationship: inverse_is_a HGNC:9035 ! PLA2G4A
+relationship: inverse_is_a HGNC:9037 ! PLA2G4C
+relationship: inverse_is_a HGNC:30038 ! PLA2G4D
 
 [Term]
-id: FPLX:PLC
+id: FPLX:000369
 name: PLC
 synonym: "Phospholipase C" EXACT []
 synonym: "phospholipase C" EXACT []
@@ -6212,15 +6232,15 @@ synonym: "Phospholipase-C" EXACT []
 synonym: "phospholipase-C" EXACT []
 synonym: "PLC" EXACT []
 xref: BEL:"PLC Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:PLCE1
-inverse_is_a: HGNC:PLCZ1
-inverse_is_a: FPLX:PLCB
-inverse_is_a: FPLX:PLCD
-inverse_is_a: FPLX:PLCG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:17175 ! PLCE1
+relationship: inverse_is_a HGNC:19218 ! PLCZ1
+relationship: inverse_is_a FPLX:000370 ! PLCB
+relationship: inverse_is_a FPLX:000371 ! PLCD
+relationship: inverse_is_a FPLX:000372 ! PLCG
 
 [Term]
-id: FPLX:PLCB
+id: FPLX:000370
 name: PLCB
 synonym: "Phospholipase C-beta" EXACT []
 synonym: "phospholipase C-beta" EXACT []
@@ -6233,14 +6253,14 @@ synonym: "phospholipase Cβ" EXACT []
 xref: BEL:"PLCB Family"
 xref: IP:IPR016280
 xref: RE:R-HSA-111854
-is_a: FPLX:PLC
-inverse_is_a: HGNC:PLCB1
-inverse_is_a: HGNC:PLCB2
-inverse_is_a: HGNC:PLCB3
-inverse_is_a: HGNC:PLCB4
+is_a: FPLX:000369 ! PLC
+relationship: inverse_is_a HGNC:15917 ! PLCB1
+relationship: inverse_is_a HGNC:9055 ! PLCB2
+relationship: inverse_is_a HGNC:9056 ! PLCB3
+relationship: inverse_is_a HGNC:9059 ! PLCB4
 
 [Term]
-id: FPLX:PLCD
+id: FPLX:000371
 name: PLCD
 synonym: "Phospholipase C-delta" EXACT []
 synonym: "phospholipase C-delta" EXACT []
@@ -6250,13 +6270,13 @@ synonym: "Phospholipase Cdelta" EXACT []
 synonym: "phospholipase Cdelta" EXACT []
 synonym: "Phospholipase Cδ" EXACT []
 synonym: "phospholipase Cδ" EXACT []
-is_a: FPLX:PLC
-inverse_is_a: HGNC:PLCD1
-inverse_is_a: HGNC:PLCD3
-inverse_is_a: HGNC:PLCD4
+is_a: FPLX:000369 ! PLC
+relationship: inverse_is_a HGNC:9060 ! PLCD1
+relationship: inverse_is_a HGNC:9061 ! PLCD3
+relationship: inverse_is_a HGNC:9062 ! PLCD4
 
 [Term]
-id: FPLX:PLCG
+id: FPLX:000372
 name: PLCG
 synonym: "PLC-gamma" EXACT []
 synonym: "PLC-γ" EXACT []
@@ -6270,28 +6290,28 @@ xref: RE:R-HSA-1169086
 xref: RE:R-HSA-1169089
 xref: RE:R-HSA-2029095
 xref: RE:R-HSA-2685653
-is_a: FPLX:PLC
-inverse_is_a: HGNC:PLCG1
-inverse_is_a: HGNC:PLCG2
+is_a: FPLX:000369 ! PLC
+relationship: inverse_is_a HGNC:9065 ! PLCG1
+relationship: inverse_is_a HGNC:9066 ! PLCG2
 
 [Term]
-id: FPLX:PLD
+id: FPLX:000373
 name: PLD
 synonym: "Phospholipase D" EXACT []
 synonym: "phospholipase D" EXACT []
 xref: BEL:"PLD Family"
 xref: ECCODE:3.1.4.4
 xref: IP:IPR015679
-is_a: FPLX:root
-inverse_is_a: HGNC:PLD1
-inverse_is_a: HGNC:PLD2
-inverse_is_a: HGNC:PLD3
-inverse_is_a: HGNC:PLD4
-inverse_is_a: HGNC:PLD5
-inverse_is_a: HGNC:PLD6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9067 ! PLD1
+relationship: inverse_is_a HGNC:9068 ! PLD2
+relationship: inverse_is_a HGNC:17158 ! PLD3
+relationship: inverse_is_a HGNC:23792 ! PLD4
+relationship: inverse_is_a HGNC:26879 ! PLD5
+relationship: inverse_is_a HGNC:30447 ! PLD6
 
 [Term]
-id: FPLX:PPAP2
+id: FPLX:000374
 name: PPAP2
 synonym: "type 2 phosphatidic acid phosphatase" EXACT []
 synonym: "type 2 phosphatidic acid phosphatases" EXACT []
@@ -6299,25 +6319,25 @@ synonym: "type II phosphatidic acid phosphatase" EXACT []
 synonym: "type II phosphatidic acid phosphatases" EXACT []
 xref: BEL:"PPAP2 Family"
 xref: RE:R-HSA-428110
-is_a: FPLX:root
-inverse_is_a: HGNC:PLPP1
-inverse_is_a: HGNC:PLPP2
-inverse_is_a: HGNC:PLPP3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9228 ! PLPP1
+relationship: inverse_is_a HGNC:9230 ! PLPP2
+relationship: inverse_is_a HGNC:9229 ! PLPP3
 
 [Term]
-id: FPLX:PPAR
+id: FPLX:000375
 name: PPAR
 synonym: "PPAR" EXACT []
 xref: BEL:"PPAR Family"
 xref: IP:IPR003074
 xref: MEDSCAN:urn:agi-protfc:ppar
-is_a: FPLX:root
-inverse_is_a: HGNC:PPARA
-inverse_is_a: HGNC:PPARD
-inverse_is_a: HGNC:PPARG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9232 ! PPARA
+relationship: inverse_is_a HGNC:9235 ! PPARD
+relationship: inverse_is_a HGNC:9236 ! PPARG
 
 [Term]
-id: FPLX:PPP1
+id: FPLX:000376
 name: PPP1
 synonym: "PP1 regulator" EXACT []
 synonym: "PP1" EXACT []
@@ -6326,12 +6346,12 @@ xref: GO:0008599
 xref: MEDSCAN:urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c
 xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%201%20complex
 xref: NEXTPROT-FAMILY:03001
-is_a: FPLX:root
-has_part: FPLX:PPP1C
-has_part: FPLX:PPP1R
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000377 ! PPP1C
+relationship: has_part FPLX:000378 ! PPP1R
 
 [Term]
-id: FPLX:PPP1C
+id: FPLX:000377
 name: PPP1C
 synonym: "PP1C" EXACT []
 synonym: "PP1c" EXACT []
@@ -6339,48 +6359,48 @@ synonym: "PPP1C" EXACT []
 xref: BEL:"PPP1C Family"
 xref: IP:IPR031675
 xref: RE:R-HSA-163538
-part_of: FPLX:PPP1
-inverse_is_a: HGNC:PPP1CA
-inverse_is_a: HGNC:PPP1CB
-inverse_is_a: HGNC:PPP1CC
+relationship: part_of FPLX:000376 ! PPP1
+relationship: inverse_is_a HGNC:9281 ! PPP1CA
+relationship: inverse_is_a HGNC:9282 ! PPP1CB
+relationship: inverse_is_a HGNC:9283 ! PPP1CC
 
 [Term]
-id: FPLX:PPP1R
+id: FPLX:000378
 name: PPP1R
 synonym: "PP1R" EXACT []
 synonym: "PP1r" EXACT []
 xref: BEL:"PPP1R Family"
-part_of: FPLX:PPP1
-inverse_is_a: HGNC:PPP1R10
-inverse_is_a: HGNC:PPP1R11
-inverse_is_a: HGNC:PPP1R12A
-inverse_is_a: HGNC:PPP1R12B
-inverse_is_a: HGNC:PPP1R12C
-inverse_is_a: HGNC:PPP1R13B
-inverse_is_a: HGNC:PPP1R14A
-inverse_is_a: HGNC:PPP1R14B
-inverse_is_a: HGNC:PPP1R14C
-inverse_is_a: HGNC:PPP1R14D
-inverse_is_a: HGNC:PPP1R15A
-inverse_is_a: HGNC:PPP1R15B
-inverse_is_a: HGNC:PPP1R16A
-inverse_is_a: HGNC:PPP1R16B
-inverse_is_a: HGNC:PPP1R1A
-inverse_is_a: HGNC:PPP1R1B
-inverse_is_a: HGNC:PPP1R1C
-inverse_is_a: HGNC:PPP1R2
-inverse_is_a: HGNC:PPP1R3A
-inverse_is_a: HGNC:PPP1R3B
-inverse_is_a: HGNC:PPP1R3C
-inverse_is_a: HGNC:PPP1R3D
-inverse_is_a: HGNC:PPP1R3F
-inverse_is_a: HGNC:PPP1R7
-inverse_is_a: HGNC:PPP1R8
-inverse_is_a: HGNC:PPP1R9A
-inverse_is_a: HGNC:PPP1R9B
-
-[Term]
-id: FPLX:PPP2
+relationship: part_of FPLX:000376 ! PPP1
+relationship: inverse_is_a HGNC:9284 ! PPP1R10
+relationship: inverse_is_a HGNC:9285 ! PPP1R11
+relationship: inverse_is_a HGNC:7618 ! PPP1R12A
+relationship: inverse_is_a HGNC:7619 ! PPP1R12B
+relationship: inverse_is_a HGNC:14947 ! PPP1R12C
+relationship: inverse_is_a HGNC:14950 ! PPP1R13B
+relationship: inverse_is_a HGNC:14871 ! PPP1R14A
+relationship: inverse_is_a HGNC:9057 ! PPP1R14B
+relationship: inverse_is_a HGNC:14952 ! PPP1R14C
+relationship: inverse_is_a HGNC:14953 ! PPP1R14D
+relationship: inverse_is_a HGNC:14375 ! PPP1R15A
+relationship: inverse_is_a HGNC:14951 ! PPP1R15B
+relationship: inverse_is_a HGNC:14941 ! PPP1R16A
+relationship: inverse_is_a HGNC:15850 ! PPP1R16B
+relationship: inverse_is_a HGNC:9286 ! PPP1R1A
+relationship: inverse_is_a HGNC:9287 ! PPP1R1B
+relationship: inverse_is_a HGNC:14940 ! PPP1R1C
+relationship: inverse_is_a HGNC:9288 ! PPP1R2
+relationship: inverse_is_a HGNC:9291 ! PPP1R3A
+relationship: inverse_is_a HGNC:14942 ! PPP1R3B
+relationship: inverse_is_a HGNC:9293 ! PPP1R3C
+relationship: inverse_is_a HGNC:9294 ! PPP1R3D
+relationship: inverse_is_a HGNC:14944 ! PPP1R3F
+relationship: inverse_is_a HGNC:9295 ! PPP1R7
+relationship: inverse_is_a HGNC:9296 ! PPP1R8
+relationship: inverse_is_a HGNC:14946 ! PPP1R9A
+relationship: inverse_is_a HGNC:9298 ! PPP1R9B
+
+[Term]
+id: FPLX:000379
 name: PPP2
 synonym: "PP2 phosphatases" EXACT []
 synonym: "PP2" EXACT []
@@ -6389,57 +6409,57 @@ synonym: "protein phosphatase 2" EXACT []
 xref: MEDSCAN:urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3
 xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%202A%20complex
 xref: RE:R-HSA-196206
-is_a: FPLX:root
-has_part: FPLX:PPP2C
-has_part: FPLX:PPP2R_A
-has_part: FPLX:PPP2R_B
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000380 ! PPP2C
+relationship: has_part FPLX:000381 ! PPP2R_A
+relationship: has_part FPLX:000382 ! PPP2R_B
 
 [Term]
-id: FPLX:PPP2C
+id: FPLX:000380
 name: PPP2C
 synonym: "PP2A catalytic C subunit" EXACT []
 synonym: "PP2A-C" EXACT []
 synonym: "PP2Ac" EXACT []
 xref: BEL:"PPP2C Family"
-part_of: FPLX:PPP2
-inverse_is_a: HGNC:PPM1J
-inverse_is_a: HGNC:PPP2CA
-inverse_is_a: HGNC:PPP2CB
+relationship: part_of FPLX:000379 ! PPP2
+relationship: inverse_is_a HGNC:20785 ! PPM1J
+relationship: inverse_is_a HGNC:9299 ! PPP2CA
+relationship: inverse_is_a HGNC:9300 ! PPP2CB
 
 [Term]
-id: FPLX:PPP2R_A
+id: FPLX:000381
 name: PPP2R-A
 synonym: "PP2A regulatory subunit A" EXACT []
 synonym: "regulatory A subunit of PP2A" EXACT []
 xref: BEL:"PPP2R Subunit A Family"
 xref: RE:R-HSA-165990
 xref: RE:R-HSA-165997
-part_of: FPLX:PPP2
-inverse_is_a: HGNC:PPP2R1A
-inverse_is_a: HGNC:PPP2R1B
+relationship: part_of FPLX:000379 ! PPP2
+relationship: inverse_is_a HGNC:9302 ! PPP2R1A
+relationship: inverse_is_a HGNC:9303 ! PPP2R1B
 
 [Term]
-id: FPLX:PPP2R_B
+id: FPLX:000382
 name: PPP2R-B
 synonym: "PP2A regulatory subunit B" EXACT []
 synonym: "regulatory B subunit of PP2A" EXACT []
 xref: BEL:"PPP2R Subunit B Family"
-part_of: FPLX:PPP2
-inverse_is_a: HGNC:PPP2R2A
-inverse_is_a: HGNC:PPP2R2B
-inverse_is_a: HGNC:PPP2R2C
-inverse_is_a: HGNC:PPP2R2D
-inverse_is_a: HGNC:PPP2R3A
-inverse_is_a: HGNC:PPP2R3B
-inverse_is_a: HGNC:PTPA
-inverse_is_a: HGNC:PPP2R5A
-inverse_is_a: HGNC:PPP2R5B
-inverse_is_a: HGNC:PPP2R5C
-inverse_is_a: HGNC:PPP2R5D
-inverse_is_a: HGNC:PPP2R5E
-
-[Term]
-id: FPLX:PPP3
+relationship: part_of FPLX:000379 ! PPP2
+relationship: inverse_is_a HGNC:9304 ! PPP2R2A
+relationship: inverse_is_a HGNC:9305 ! PPP2R2B
+relationship: inverse_is_a HGNC:9306 ! PPP2R2C
+relationship: inverse_is_a HGNC:23732 ! PPP2R2D
+relationship: inverse_is_a HGNC:9307 ! PPP2R3A
+relationship: inverse_is_a HGNC:13417 ! PPP2R3B
+relationship: inverse_is_a HGNC:9308 ! PTPA
+relationship: inverse_is_a HGNC:9309 ! PPP2R5A
+relationship: inverse_is_a HGNC:9310 ! PPP2R5B
+relationship: inverse_is_a HGNC:9311 ! PPP2R5C
+relationship: inverse_is_a HGNC:9312 ! PPP2R5D
+relationship: inverse_is_a HGNC:9313 ! PPP2R5E
+
+[Term]
+id: FPLX:000383
 name: PPP3
 synonym: "calcineurin" EXACT []
 synonym: "CaN" EXACT []
@@ -6448,12 +6468,12 @@ synonym: "protein phosphatase 2B" EXACT []
 xref: BEL:"Calcineurin Complex"
 xref: BEL:"PPP3 Family"
 xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%203
-is_a: FPLX:root
-has_part: FPLX:PPP3C
-has_part: FPLX:PPP3R
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000384 ! PPP3C
+relationship: has_part FPLX:000385 ! PPP3R
 
 [Term]
-id: FPLX:PPP3C
+id: FPLX:000384
 name: PPP3C
 synonym: "Calcineurin catalytic subunit" EXACT []
 synonym: "catalytic subunit of calcineurin" EXACT []
@@ -6462,24 +6482,24 @@ xref: BEL:"PPP3C Family"
 xref: RE:R-HSA-201779
 xref: RE:R-HSA-201798
 xref: SIGNOR:SIGNOR-PF18
-part_of: FPLX:PPP3
-inverse_is_a: HGNC:PPP3CA
-inverse_is_a: HGNC:PPP3CB
-inverse_is_a: HGNC:PPP3CC
+relationship: part_of FPLX:000383 ! PPP3
+relationship: inverse_is_a HGNC:9314 ! PPP3CA
+relationship: inverse_is_a HGNC:9315 ! PPP3CB
+relationship: inverse_is_a HGNC:9316 ! PPP3CC
 
 [Term]
-id: FPLX:PPP3R
+id: FPLX:000385
 name: PPP3R
 synonym: "Calcineurin regulatory subunit" EXACT []
 synonym: "regulatory subunit of calcineurin" EXACT []
 xref: BEL:"PPP3R Family"
 xref: NEXTPROT-FAMILY:00421
-part_of: FPLX:PPP3
-inverse_is_a: HGNC:PPP3R1
-inverse_is_a: HGNC:PPP3R2
+relationship: part_of FPLX:000383 ! PPP3
+relationship: inverse_is_a HGNC:9317 ! PPP3R1
+relationship: inverse_is_a HGNC:9318 ! PPP3R2
 
 [Term]
-id: FPLX:PRC1_complex
+id: FPLX:000386
 name: PRC1-complex
 synonym: "polycomb Repressive Complex (PRC) 1" EXACT []
 synonym: "Polycomb Repressive Complex 1" EXACT []
@@ -6493,24 +6513,24 @@ xref: BEL:"PRC1 Maintenance Complex"
 xref: GO:0035102
 xref: MEDSCAN:urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd
 xref: NCIT:C19866
-is_a: FPLX:root
-has_part: HGNC:BMI1
-has_part: HGNC:CBX2
-has_part: HGNC:CBX4
-has_part: HGNC:CBX8
-has_part: HGNC:PCGF2
-has_part: HGNC:PHC1
-has_part: HGNC:PHC2
-has_part: HGNC:PHC3
-has_part: HGNC:PHF1
-has_part: HGNC:RING1
-has_part: HGNC:RNF2
-has_part: HGNC:SCMH1
-has_part: HGNC:YY1
-has_part: HGNC:ZNF134
-
-[Term]
-id: FPLX:PRC2_complex
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1066 ! BMI1
+relationship: has_part HGNC:1552 ! CBX2
+relationship: has_part HGNC:1554 ! CBX4
+relationship: has_part HGNC:15962 ! CBX8
+relationship: has_part HGNC:12929 ! PCGF2
+relationship: has_part HGNC:3182 ! PHC1
+relationship: has_part HGNC:3183 ! PHC2
+relationship: has_part HGNC:15682 ! PHC3
+relationship: has_part HGNC:8919 ! PHF1
+relationship: has_part HGNC:10018 ! RING1
+relationship: has_part HGNC:10061 ! RNF2
+relationship: has_part HGNC:19003 ! SCMH1
+relationship: has_part HGNC:12856 ! YY1
+relationship: has_part HGNC:12918 ! ZNF134
+
+[Term]
+id: FPLX:000387
 name: PRC2-complex
 synonym: "Polycomb Repressive Complex 2" EXACT []
 synonym: "Polycomb repressive complex 2" EXACT []
@@ -6522,14 +6542,14 @@ synonym: "PRC2" EXACT []
 xref: BEL:"PRC2 Initiation Complex"
 xref: GO:0035098
 xref: MEDSCAN:urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b
-is_a: FPLX:root
-has_part: HGNC:EED
-has_part: HGNC:EZH1
-has_part: HGNC:EZH2
-has_part: HGNC:SUZ12
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3188 ! EED
+relationship: has_part HGNC:3526 ! EZH1
+relationship: has_part HGNC:3527 ! EZH2
+relationship: has_part HGNC:17101 ! SUZ12
 
 [Term]
-id: FPLX:PRDX
+id: FPLX:000388
 name: PRDX
 synonym: "Peroxiredoxin" EXACT []
 synonym: "peroxiredoxin" EXACT []
@@ -6537,16 +6557,16 @@ synonym: "Peroxiredoxins" EXACT []
 synonym: "peroxiredoxins" EXACT []
 xref: BEL:"PRDX Family"
 xref: ECCODE:1.11.1.15
-is_a: FPLX:root
-inverse_is_a: HGNC:PRDX1
-inverse_is_a: HGNC:PRDX2
-inverse_is_a: HGNC:PRDX3
-inverse_is_a: HGNC:PRDX4
-inverse_is_a: HGNC:PRDX5
-inverse_is_a: HGNC:PRDX6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9352 ! PRDX1
+relationship: inverse_is_a HGNC:9353 ! PRDX2
+relationship: inverse_is_a HGNC:9354 ! PRDX3
+relationship: inverse_is_a HGNC:17169 ! PRDX4
+relationship: inverse_is_a HGNC:9355 ! PRDX5
+relationship: inverse_is_a HGNC:16753 ! PRDX6
 
 [Term]
-id: FPLX:PRKAC
+id: FPLX:000389
 name: PRKAC
 synonym: "PKA catalytic subunit" EXACT []
 synonym: "PKA catalytic subunits" EXACT []
@@ -6556,13 +6576,13 @@ synonym: "Protein kinase A catalytic subunits" EXACT []
 synonym: "protein kinase A catalytic subunits" EXACT []
 xref: BEL:"PRKA Family"
 xref: SIGNOR:SIGNOR-PF17
-part_of: FPLX:PKA
-inverse_is_a: HGNC:PRKACA
-inverse_is_a: HGNC:PRKACB
-inverse_is_a: HGNC:PRKACG
+relationship: part_of FPLX:000363 ! PKA
+relationship: inverse_is_a HGNC:9380 ! PRKACA
+relationship: inverse_is_a HGNC:9381 ! PRKACB
+relationship: inverse_is_a HGNC:9382 ! PRKACG
 
 [Term]
-id: FPLX:PRKAR
+id: FPLX:000390
 name: PRKAR
 synonym: "PKA regulatory subunit" EXACT []
 synonym: "PKA regulatory subunits" EXACT []
@@ -6577,14 +6597,14 @@ xref: RE:R-HSA-111921
 xref: RE:R-HSA-111923
 xref: RE:R-HSA-5610566
 xref: RE:R-HSA-5610568
-part_of: FPLX:PKA
-inverse_is_a: HGNC:PRKAR1A
-inverse_is_a: HGNC:PRKAR1B
-inverse_is_a: HGNC:PRKAR2A
-inverse_is_a: HGNC:PRKAR2B
+relationship: part_of FPLX:000363 ! PKA
+relationship: inverse_is_a HGNC:9388 ! PRKAR1A
+relationship: inverse_is_a HGNC:9390 ! PRKAR1B
+relationship: inverse_is_a HGNC:9391 ! PRKAR2A
+relationship: inverse_is_a HGNC:9392 ! PRKAR2B
 
 [Term]
-id: FPLX:PRKG
+id: FPLX:000391
 name: PRKG
 synonym: "PKG" EXACT []
 synonym: "protein kinase G" EXACT []
@@ -6595,12 +6615,12 @@ xref: IP:IPR035014
 xref: RE:R-HSA-418379
 xref: RE:R-HSA-4551456
 xref: RE:R-HSA-4551462
-is_a: FPLX:root
-inverse_is_a: HGNC:PRKG1
-inverse_is_a: HGNC:PRKG2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9414 ! PRKG1
+relationship: inverse_is_a HGNC:9416 ! PRKG2
 
 [Term]
-id: FPLX:Propionyl_CoA_carboxylase
+id: FPLX:000392
 name: Propionyl-CoA-carboxylase
 synonym: "Propionyl-CoA carboxylase" EXACT []
 synonym: "propionyl-CoA carboxylase" EXACT []
@@ -6612,19 +6632,19 @@ xref: RE:R-HSA-3323122
 xref: RE:R-HSA-3323155
 xref: RE:R-HSA-71025
 xref: RE:R-HSA-71026
-is_a: FPLX:root
-has_part: HGNC:PCCA
-has_part: HGNC:PCCB
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8653 ! PCCA
+relationship: has_part HGNC:8654 ! PCCB
 
 [Term]
-id: FPLX:Protease
+id: FPLX:000393
 name: Protease
 synonym: "protease" EXACT []
 xref: NCIT:C16965
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:Proteasome
+id: FPLX:000394
 name: Proteasome
 synonym: "proteasome endopeptidase" EXACT []
 synonym: "proteasome" EXACT []
@@ -6632,78 +6652,78 @@ xref: BEL:"Proteasome Complex"
 xref: ECCODE:3.4.25.1
 xref: GO:0000502
 xref: MESH:D046988
-is_a: FPLX:root
-has_part: HGNC:PSMA1
-has_part: HGNC:PSMA2
-has_part: HGNC:PSMA3
-has_part: HGNC:PSMA4
-has_part: HGNC:PSMA5
-has_part: HGNC:PSMA6
-has_part: HGNC:PSMA7
-has_part: HGNC:PSMA8
-has_part: HGNC:PSMB1
-has_part: HGNC:PSMB10
-has_part: HGNC:PSMB2
-has_part: HGNC:PSMB3
-has_part: HGNC:PSMB4
-has_part: HGNC:PSMB5
-has_part: HGNC:PSMB6
-has_part: HGNC:PSMB7
-has_part: HGNC:PSMB8
-has_part: HGNC:PSMB9
-has_part: HGNC:PSMC1
-has_part: HGNC:PSMC2
-has_part: HGNC:PSMC3
-has_part: HGNC:PSMC4
-has_part: HGNC:PSMC5
-has_part: HGNC:PSMC6
-has_part: HGNC:PSMD1
-has_part: HGNC:PSMD10
-has_part: HGNC:PSMD11
-has_part: HGNC:PSMD12
-has_part: HGNC:PSMD13
-has_part: HGNC:PSMD14
-has_part: HGNC:PSMD2
-has_part: HGNC:PSMD3
-has_part: HGNC:PSMD4
-has_part: HGNC:PSMD5
-has_part: HGNC:PSMD6
-has_part: HGNC:PSMD7
-has_part: HGNC:PSMD8
-has_part: HGNC:PSMD9
-has_part: HGNC:PSME1
-has_part: HGNC:PSME2
-has_part: HGNC:PSME3
-has_part: HGNC:PSMF1
-has_part: HGNC:SEM1
-has_part: HGNC:USP5
-
-[Term]
-id: FPLX:PTGER
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9530 ! PSMA1
+relationship: has_part HGNC:9531 ! PSMA2
+relationship: has_part HGNC:9532 ! PSMA3
+relationship: has_part HGNC:9533 ! PSMA4
+relationship: has_part HGNC:9534 ! PSMA5
+relationship: has_part HGNC:9535 ! PSMA6
+relationship: has_part HGNC:9536 ! PSMA7
+relationship: has_part HGNC:22985 ! PSMA8
+relationship: has_part HGNC:9537 ! PSMB1
+relationship: has_part HGNC:9538 ! PSMB10
+relationship: has_part HGNC:9539 ! PSMB2
+relationship: has_part HGNC:9540 ! PSMB3
+relationship: has_part HGNC:9541 ! PSMB4
+relationship: has_part HGNC:9542 ! PSMB5
+relationship: has_part HGNC:9543 ! PSMB6
+relationship: has_part HGNC:9544 ! PSMB7
+relationship: has_part HGNC:9545 ! PSMB8
+relationship: has_part HGNC:9546 ! PSMB9
+relationship: has_part HGNC:9547 ! PSMC1
+relationship: has_part HGNC:9548 ! PSMC2
+relationship: has_part HGNC:9549 ! PSMC3
+relationship: has_part HGNC:9551 ! PSMC4
+relationship: has_part HGNC:9552 ! PSMC5
+relationship: has_part HGNC:9553 ! PSMC6
+relationship: has_part HGNC:9554 ! PSMD1
+relationship: has_part HGNC:9555 ! PSMD10
+relationship: has_part HGNC:9556 ! PSMD11
+relationship: has_part HGNC:9557 ! PSMD12
+relationship: has_part HGNC:9558 ! PSMD13
+relationship: has_part HGNC:16889 ! PSMD14
+relationship: has_part HGNC:9559 ! PSMD2
+relationship: has_part HGNC:9560 ! PSMD3
+relationship: has_part HGNC:9561 ! PSMD4
+relationship: has_part HGNC:9563 ! PSMD5
+relationship: has_part HGNC:9564 ! PSMD6
+relationship: has_part HGNC:9565 ! PSMD7
+relationship: has_part HGNC:9566 ! PSMD8
+relationship: has_part HGNC:9567 ! PSMD9
+relationship: has_part HGNC:9568 ! PSME1
+relationship: has_part HGNC:9569 ! PSME2
+relationship: has_part HGNC:9570 ! PSME3
+relationship: has_part HGNC:9571 ! PSMF1
+relationship: has_part HGNC:10845 ! SEM1
+relationship: has_part HGNC:12628 ! USP5
+
+[Term]
+id: FPLX:000395
 name: PTGER
 synonym: "prostaglandin E receptor" EXACT []
 xref: BEL:"PTGER Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:PTGER1
-inverse_is_a: HGNC:PTGER2
-inverse_is_a: HGNC:PTGER3
-inverse_is_a: HGNC:PTGER4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9593 ! PTGER1
+relationship: inverse_is_a HGNC:9594 ! PTGER2
+relationship: inverse_is_a HGNC:9595 ! PTGER3
+relationship: inverse_is_a HGNC:9596 ! PTGER4
 
 [Term]
-id: FPLX:PYG
+id: FPLX:000396
 name: PYG
 synonym: "Glycogen phosphorylase" EXACT []
 synonym: "Glycogen phosphorylases" EXACT []
 synonym: "glycogen phosphorylase" EXACT []
 synonym: "glycogen phosphorylases" EXACT []
 synonym: "PYG" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:PYGB
-inverse_is_a: HGNC:PYGL
-inverse_is_a: HGNC:PYGM
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:9723 ! PYGB
+relationship: inverse_is_a HGNC:9725 ! PYGL
+relationship: inverse_is_a HGNC:9726 ! PYGM
 
 [Term]
-id: FPLX:RAB
+id: FPLX:000397
 name: RAB
 synonym: "Rab GTPase" EXACT []
 synonym: "Rab GTPases" EXACT []
@@ -6716,90 +6736,90 @@ synonym: "Rabs" EXACT []
 xref: BEL:"RAB Family"
 xref: MEDSCAN:urn:agi-protfc:rab
 xref: NEXTPROT-FAMILY:03661
-is_a: FPLX:root
-inverse_is_a: HGNC:RAB10
-inverse_is_a: HGNC:RAB11A
-inverse_is_a: HGNC:RAB11B
-inverse_is_a: HGNC:RAB12
-inverse_is_a: HGNC:RAB13
-inverse_is_a: HGNC:RAB14
-inverse_is_a: HGNC:RAB15
-inverse_is_a: HGNC:RAB17
-inverse_is_a: HGNC:RAB18
-inverse_is_a: HGNC:RAB19
-inverse_is_a: HGNC:RAB1A
-inverse_is_a: HGNC:RAB1B
-inverse_is_a: HGNC:RAB1C
-inverse_is_a: HGNC:RAB20
-inverse_is_a: HGNC:RAB21
-inverse_is_a: HGNC:RAB22A
-inverse_is_a: HGNC:RAB23
-inverse_is_a: HGNC:RAB24
-inverse_is_a: HGNC:RAB25
-inverse_is_a: HGNC:RAB26
-inverse_is_a: HGNC:RAB27A
-inverse_is_a: HGNC:RAB27B
-inverse_is_a: HGNC:RAB28
-inverse_is_a: HGNC:RAB2A
-inverse_is_a: HGNC:RAB2B
-inverse_is_a: HGNC:RAB30
-inverse_is_a: HGNC:RAB31
-inverse_is_a: HGNC:RAB32
-inverse_is_a: HGNC:RAB33A
-inverse_is_a: HGNC:RAB33B
-inverse_is_a: HGNC:RAB34
-inverse_is_a: HGNC:RAB35
-inverse_is_a: HGNC:RAB36
-inverse_is_a: HGNC:RAB37
-inverse_is_a: HGNC:RAB38
-inverse_is_a: HGNC:RAB39A
-inverse_is_a: HGNC:RAB39B
-inverse_is_a: HGNC:RAB3A
-inverse_is_a: HGNC:RAB3B
-inverse_is_a: HGNC:RAB3C
-inverse_is_a: HGNC:RAB3D
-inverse_is_a: HGNC:RAB40A
-inverse_is_a: HGNC:RAB40AL
-inverse_is_a: HGNC:RAB40B
-inverse_is_a: HGNC:RAB40C
-inverse_is_a: HGNC:RAB41
-inverse_is_a: HGNC:RAB42
-inverse_is_a: HGNC:RAB43
-inverse_is_a: HGNC:RAB44
-inverse_is_a: HGNC:RAB4A
-inverse_is_a: HGNC:RAB4B
-inverse_is_a: HGNC:RAB5A
-inverse_is_a: HGNC:RAB5B
-inverse_is_a: HGNC:RAB5C
-inverse_is_a: HGNC:RAB6A
-inverse_is_a: HGNC:RAB6B
-inverse_is_a: HGNC:RAB6C
-inverse_is_a: HGNC:RAB7A
-inverse_is_a: HGNC:RAB7B
-inverse_is_a: HGNC:RAB29
-inverse_is_a: HGNC:RAB8A
-inverse_is_a: HGNC:RAB8B
-inverse_is_a: HGNC:RAB9A
-inverse_is_a: HGNC:RAB9B
-inverse_is_a: HGNC:RABL2A
-inverse_is_a: HGNC:RABL2B
-inverse_is_a: HGNC:RABL3
-inverse_is_a: HGNC:IFT22
-
-[Term]
-id: FPLX:RAC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9759 ! RAB10
+relationship: inverse_is_a HGNC:9760 ! RAB11A
+relationship: inverse_is_a HGNC:9761 ! RAB11B
+relationship: inverse_is_a HGNC:31332 ! RAB12
+relationship: inverse_is_a HGNC:9762 ! RAB13
+relationship: inverse_is_a HGNC:16524 ! RAB14
+relationship: inverse_is_a HGNC:20150 ! RAB15
+relationship: inverse_is_a HGNC:16523 ! RAB17
+relationship: inverse_is_a HGNC:14244 ! RAB18
+relationship: inverse_is_a HGNC:19982 ! RAB19
+relationship: inverse_is_a HGNC:9758 ! RAB1A
+relationship: inverse_is_a HGNC:18370 ! RAB1B
+relationship: inverse_is_a HGNC:23683 ! RAB1C
+relationship: inverse_is_a HGNC:18260 ! RAB20
+relationship: inverse_is_a HGNC:18263 ! RAB21
+relationship: inverse_is_a HGNC:9764 ! RAB22A
+relationship: inverse_is_a HGNC:14263 ! RAB23
+relationship: inverse_is_a HGNC:9765 ! RAB24
+relationship: inverse_is_a HGNC:18238 ! RAB25
+relationship: inverse_is_a HGNC:14259 ! RAB26
+relationship: inverse_is_a HGNC:9766 ! RAB27A
+relationship: inverse_is_a HGNC:9767 ! RAB27B
+relationship: inverse_is_a HGNC:9768 ! RAB28
+relationship: inverse_is_a HGNC:9763 ! RAB2A
+relationship: inverse_is_a HGNC:20246 ! RAB2B
+relationship: inverse_is_a HGNC:9770 ! RAB30
+relationship: inverse_is_a HGNC:9771 ! RAB31
+relationship: inverse_is_a HGNC:9772 ! RAB32
+relationship: inverse_is_a HGNC:9773 ! RAB33A
+relationship: inverse_is_a HGNC:16075 ! RAB33B
+relationship: inverse_is_a HGNC:16519 ! RAB34
+relationship: inverse_is_a HGNC:9774 ! RAB35
+relationship: inverse_is_a HGNC:9775 ! RAB36
+relationship: inverse_is_a HGNC:30268 ! RAB37
+relationship: inverse_is_a HGNC:9776 ! RAB38
+relationship: inverse_is_a HGNC:16521 ! RAB39A
+relationship: inverse_is_a HGNC:16499 ! RAB39B
+relationship: inverse_is_a HGNC:9777 ! RAB3A
+relationship: inverse_is_a HGNC:9778 ! RAB3B
+relationship: inverse_is_a HGNC:30269 ! RAB3C
+relationship: inverse_is_a HGNC:9779 ! RAB3D
+relationship: inverse_is_a HGNC:18283 ! RAB40A
+relationship: inverse_is_a HGNC:25410 ! RAB40AL
+relationship: inverse_is_a HGNC:18284 ! RAB40B
+relationship: inverse_is_a HGNC:18285 ! RAB40C
+relationship: inverse_is_a HGNC:18293 ! RAB41
+relationship: inverse_is_a HGNC:28702 ! RAB42
+relationship: inverse_is_a HGNC:19983 ! RAB43
+relationship: inverse_is_a HGNC:21068 ! RAB44
+relationship: inverse_is_a HGNC:9781 ! RAB4A
+relationship: inverse_is_a HGNC:9782 ! RAB4B
+relationship: inverse_is_a HGNC:9783 ! RAB5A
+relationship: inverse_is_a HGNC:9784 ! RAB5B
+relationship: inverse_is_a HGNC:9785 ! RAB5C
+relationship: inverse_is_a HGNC:9786 ! RAB6A
+relationship: inverse_is_a HGNC:14902 ! RAB6B
+relationship: inverse_is_a HGNC:16525 ! RAB6C
+relationship: inverse_is_a HGNC:9788 ! RAB7A
+relationship: inverse_is_a HGNC:30513 ! RAB7B
+relationship: inverse_is_a HGNC:9789 ! RAB29
+relationship: inverse_is_a HGNC:7007 ! RAB8A
+relationship: inverse_is_a HGNC:30273 ! RAB8B
+relationship: inverse_is_a HGNC:9792 ! RAB9A
+relationship: inverse_is_a HGNC:14090 ! RAB9B
+relationship: inverse_is_a HGNC:9799 ! RABL2A
+relationship: inverse_is_a HGNC:9800 ! RABL2B
+relationship: inverse_is_a HGNC:18072 ! RABL3
+relationship: inverse_is_a HGNC:21895 ! IFT22
+
+[Term]
+id: FPLX:000398
 name: RAC
 synonym: "RAC" EXACT []
 xref: BEL:"RAC Family"
 xref: NEXTPROT-FAMILY:03066
-is_a: FPLX:root
-inverse_is_a: HGNC:RAC1
-inverse_is_a: HGNC:RAC2
-inverse_is_a: HGNC:RAC3
-inverse_is_a: HGNC:RHOG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9801 ! RAC1
+relationship: inverse_is_a HGNC:9802 ! RAC2
+relationship: inverse_is_a HGNC:9803 ! RAC3
+relationship: inverse_is_a HGNC:672 ! RHOG
 
 [Term]
-id: FPLX:RAF
+id: FPLX:000399
 name: RAF
 synonym: "RAF" EXACT []
 synonym: "Raf" EXACT []
@@ -6809,13 +6829,13 @@ xref: RE:R-HSA-5672708
 xref: RE:R-HSA-5672726
 xref: RE:R-HSA-5674134
 xref: RE:R-HSA-5674136
-is_a: FPLX:MAP3K
-inverse_is_a: HGNC:ARAF
-inverse_is_a: HGNC:BRAF
-inverse_is_a: HGNC:RAF1
+is_a: FPLX:000282 ! MAP3K
+relationship: inverse_is_a HGNC:646 ! ARAF
+relationship: inverse_is_a HGNC:1097 ! BRAF
+relationship: inverse_is_a HGNC:9829 ! RAF1
 
 [Term]
-id: FPLX:RAL
+id: FPLX:000400
 name: RAL
 synonym: "RAL family" EXACT []
 synonym: "Ral family" EXACT []
@@ -6827,43 +6847,43 @@ synonym: "RAL" EXACT []
 xref: IP:IPR028412
 xref: RE:R-HSA-170994
 xref: RE:R-HSA-170998
-is_a: FPLX:root
-inverse_is_a: HGNC:RALA
-inverse_is_a: HGNC:RALB
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9839 ! RALA
+relationship: inverse_is_a HGNC:9840 ! RALB
 
 [Term]
-id: FPLX:RAP1
+id: FPLX:000401
 name: RAP1
 synonym: "Rap1" EXACT []
 xref: NEXTPROT-FAMILY:04773
-is_a: FPLX:root
-inverse_is_a: HGNC:RAP1A
-inverse_is_a: HGNC:RAP1B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9855 ! RAP1A
+relationship: inverse_is_a HGNC:9857 ! RAP1B
 
 [Term]
-id: FPLX:RAPGEF
+id: FPLX:000402
 name: RAPGEF
 synonym: "Rap guanine nucleotide exchange factor" EXACT []
 synonym: "Rap guanine nucleotide exchange factors" EXACT []
 synonym: "RapGEFs" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:RAPGEF1
-inverse_is_a: HGNC:RAPGEF2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4568 ! RAPGEF1
+relationship: inverse_is_a HGNC:16854 ! RAPGEF2
 
 [Term]
-id: FPLX:RAR
+id: FPLX:000403
 name: RAR
 synonym: "RAR" EXACT []
 synonym: "retinoic acid receptors" EXACT []
 xref: BEL:"RAR Family"
 xref: NCIT:C17532
-is_a: FPLX:root
-inverse_is_a: HGNC:RARA
-inverse_is_a: HGNC:RARB
-inverse_is_a: HGNC:RARG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9864 ! RARA
+relationship: inverse_is_a HGNC:9865 ! RARB
+relationship: inverse_is_a HGNC:9866 ! RARG
 
 [Term]
-id: FPLX:RAS
+id: FPLX:000404
 name: RAS
 synonym: "Ras GTPase" EXACT []
 synonym: "RAS" EXACT []
@@ -6879,60 +6899,60 @@ xref: RE:R-HSA-109796
 xref: RE:R-HSA-167204
 xref: RE:R-HSA-6802607
 xref: RE:R-HSA-6802608
-is_a: FPLX:root
-inverse_is_a: HGNC:KRAS
-inverse_is_a: HGNC:HRAS
-inverse_is_a: HGNC:NRAS
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6407 ! KRAS
+relationship: inverse_is_a HGNC:5173 ! HRAS
+relationship: inverse_is_a HGNC:7989 ! NRAS
 
 [Term]
-id: FPLX:RASA
+id: FPLX:000405
 name: RASA
 synonym: "RASA" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:RASA1
-inverse_is_a: HGNC:RASA2
-inverse_is_a: HGNC:RASA3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9871 ! RASA1
+relationship: inverse_is_a HGNC:9872 ! RASA2
+relationship: inverse_is_a HGNC:20331 ! RASA3
 
 [Term]
-id: FPLX:RASAL
+id: FPLX:000406
 name: RASAL
 synonym: "RASAL" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:RASAL1
-inverse_is_a: HGNC:RASAL2
-inverse_is_a: HGNC:RASAL3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9873 ! RASAL1
+relationship: inverse_is_a HGNC:9874 ! RASAL2
+relationship: inverse_is_a HGNC:26129 ! RASAL3
 
 [Term]
-id: FPLX:RasGAP
+id: FPLX:000407
 name: RasGAP
 synonym: "RasGAP" EXACT []
 synonym: "RasGAPs" EXACT []
 xref: XFAM:PF00616
 xref: RE:R-HSA-5658216
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:RASGRF
+id: FPLX:000408
 name: RASGRF
 synonym: "RASGRF" EXACT []
 xref: RE:R-HSA-442734
-is_a: FPLX:root
-inverse_is_a: HGNC:RASGRF1
-inverse_is_a: HGNC:RASGRF2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9875 ! RASGRF1
+relationship: inverse_is_a HGNC:9876 ! RASGRF2
 
 [Term]
-id: FPLX:RASGRP
+id: FPLX:000409
 name: RASGRP
 synonym: "RASGRP" EXACT []
 xref: RE:R-HSA-2685656
-is_a: FPLX:root
-inverse_is_a: HGNC:RASGRP1
-inverse_is_a: HGNC:RASGRP2
-inverse_is_a: HGNC:RASGRP3
-inverse_is_a: HGNC:RASGRP4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9878 ! RASGRP1
+relationship: inverse_is_a HGNC:9879 ! RASGRP2
+relationship: inverse_is_a HGNC:14545 ! RASGRP3
+relationship: inverse_is_a HGNC:18958 ! RASGRP4
 
 [Term]
-id: FPLX:RASSF
+id: FPLX:000410
 name: RASSF
 synonym: "RAS association domain family" EXACT []
 synonym: "Ras association domain family" EXACT []
@@ -6940,20 +6960,20 @@ synonym: "RAS-association domain family" EXACT []
 synonym: "Ras-association domain family" EXACT []
 synonym: "RASSF family" EXACT []
 xref: IP:IPR033614
-is_a: FPLX:root
-inverse_is_a: HGNC:RASSF1
-inverse_is_a: HGNC:RASSF2
-inverse_is_a: HGNC:RASSF3
-inverse_is_a: HGNC:RASSF4
-inverse_is_a: HGNC:RASSF5
-inverse_is_a: HGNC:RASSF6
-inverse_is_a: HGNC:RASSF7
-inverse_is_a: HGNC:RASSF8
-inverse_is_a: HGNC:RASSF9
-inverse_is_a: HGNC:RASSF10
-
-[Term]
-id: FPLX:RFC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9882 ! RASSF1
+relationship: inverse_is_a HGNC:9883 ! RASSF2
+relationship: inverse_is_a HGNC:14271 ! RASSF3
+relationship: inverse_is_a HGNC:20793 ! RASSF4
+relationship: inverse_is_a HGNC:17609 ! RASSF5
+relationship: inverse_is_a HGNC:20796 ! RASSF6
+relationship: inverse_is_a HGNC:1166 ! RASSF7
+relationship: inverse_is_a HGNC:13232 ! RASSF8
+relationship: inverse_is_a HGNC:15739 ! RASSF9
+relationship: inverse_is_a HGNC:33984 ! RASSF10
+
+[Term]
+id: FPLX:000411
 name: RFC
 synonym: "DNA replication factor C complex" EXACT []
 synonym: "DNA replication factor C" EXACT []
@@ -6965,15 +6985,15 @@ xref: GO:0005663
 xref: MEDSCAN:urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e
 xref: RE:R-HSA-174454
 xref: RE:R-HSA-68436
-is_a: FPLX:root
-has_part: HGNC:RFC1
-has_part: HGNC:RFC2
-has_part: HGNC:RFC3
-has_part: HGNC:RFC4
-has_part: HGNC:RFC5
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9969 ! RFC1
+relationship: has_part HGNC:9970 ! RFC2
+relationship: has_part HGNC:9971 ! RFC3
+relationship: has_part HGNC:9972 ! RFC4
+relationship: has_part HGNC:9973 ! RFC5
 
 [Term]
-id: FPLX:RFX
+id: FPLX:000412
 name: RFX
 synonym: "regulatory family X" EXACT []
 synonym: "RF-X" EXACT []
@@ -6982,30 +7002,30 @@ synonym: "RFX proteins" EXACT []
 synonym: "RFX" EXACT []
 xref: BEL:"RFX Family"
 xref: MEDSCAN:urn:agi-aopfc:0000157
-is_a: FPLX:root
-inverse_is_a: HGNC:RFX1
-inverse_is_a: HGNC:RFX2
-inverse_is_a: HGNC:RFX3
-inverse_is_a: HGNC:RFX4
-inverse_is_a: HGNC:RFX5
-inverse_is_a: HGNC:RFX6
-inverse_is_a: HGNC:RFX7
-inverse_is_a: HGNC:RFX8
-
-[Term]
-id: FPLX:RGL
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9982 ! RFX1
+relationship: inverse_is_a HGNC:9983 ! RFX2
+relationship: inverse_is_a HGNC:9984 ! RFX3
+relationship: inverse_is_a HGNC:9985 ! RFX4
+relationship: inverse_is_a HGNC:9986 ! RFX5
+relationship: inverse_is_a HGNC:21478 ! RFX6
+relationship: inverse_is_a HGNC:25777 ! RFX7
+relationship: inverse_is_a HGNC:37253 ! RFX8
+
+[Term]
+id: FPLX:000413
 name: RGL
 synonym: "RAL guanine nucleotide dissociation stimulator like" EXACT []
 synonym: "Ral guanine nucleotide dissociation stimulator like" EXACT []
 synonym: "ral guanine nucleotide dissociation stimulator like" EXACT []
 synonym: "RALGDS-like" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:RGL1
-inverse_is_a: HGNC:RGL2
-inverse_is_a: HGNC:RGL3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:30281 ! RGL1
+relationship: inverse_is_a HGNC:9769 ! RGL2
+relationship: inverse_is_a HGNC:30282 ! RGL3
 
 [Term]
-id: FPLX:RHO
+id: FPLX:000414
 name: RHO
 synonym: "Rho family" EXACT []
 synonym: "RHO" EXACT []
@@ -7015,13 +7035,13 @@ xref: NEXTPROT-FAMILY:03668
 xref: RE:R-HSA-419160
 xref: RE:R-HSA-419161
 xref: RE:R-HSA-419164
-is_a: FPLX:root
-inverse_is_a: HGNC:RHOA
-inverse_is_a: HGNC:RHOB
-inverse_is_a: HGNC:RHOC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:667 ! RHOA
+relationship: inverse_is_a HGNC:668 ! RHOB
+relationship: inverse_is_a HGNC:669 ! RHOC
 
 [Term]
-id: FPLX:RhoGDI
+id: FPLX:000415
 name: RhoGDI
 synonym: "Rho-GDI" EXACT []
 synonym: "RHOGDI" EXACT []
@@ -7030,13 +7050,13 @@ synonym: "rhoGDI" EXACT []
 synonym: "RhoGDIs" EXACT []
 xref: GO:0005094
 xref: IP:IPR000406
-is_a: FPLX:root
-inverse_is_a: HGNC:ARHGDIA
-inverse_is_a: HGNC:ARHGDIB
-inverse_is_a: HGNC:ARHGDIG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:678 ! ARHGDIA
+relationship: inverse_is_a HGNC:679 ! ARHGDIB
+relationship: inverse_is_a HGNC:680 ! ARHGDIG
 
 [Term]
-id: FPLX:RNApo_I
+id: FPLX:000416
 name: RNApo-I
 synonym: "Pol I" EXACT []
 synonym: "RNA polymerase 1" EXACT []
@@ -7044,14 +7064,14 @@ synonym: "RNA polymerase I" EXACT []
 xref: BEL:"RNApo I Complex"
 xref: GO:0005736
 xref: NCIT:C95947
-is_a: FPLX:root
-has_part: HGNC:POLR1A
-has_part: HGNC:POLR1B
-has_part: HGNC:POLR1C
-has_part: HGNC:POLR1D
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:17264 ! POLR1A
+relationship: has_part HGNC:20454 ! POLR1B
+relationship: has_part HGNC:20194 ! POLR1C
+relationship: has_part HGNC:20422 ! POLR1D
 
 [Term]
-id: FPLX:RNApo_II
+id: FPLX:000417
 name: RNApo-II
 synonym: "RNA polymerase II" EXACT []
 synonym: "RNAP II" EXACT []
@@ -7059,32 +7079,32 @@ xref: BEL:"RNApo II Complex"
 xref: GO:0005665
 xref: MEDSCAN:urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4
 xref: NCIT:C95948
-is_a: FPLX:root
-has_part: HGNC:POLR2A
-has_part: HGNC:POLR2B
-has_part: HGNC:POLR2C
-has_part: HGNC:POLR2D
-has_part: HGNC:POLR2E
-has_part: HGNC:POLR2F
-has_part: HGNC:POLR2G
-has_part: HGNC:POLR2H
-has_part: HGNC:POLR2I
-has_part: HGNC:POLR2J
-has_part: HGNC:POLR2J2
-has_part: HGNC:POLR2K
-has_part: HGNC:POLR2L
-
-[Term]
-id: FPLX:ROBO
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9187 ! POLR2A
+relationship: has_part HGNC:9188 ! POLR2B
+relationship: has_part HGNC:9189 ! POLR2C
+relationship: has_part HGNC:9191 ! POLR2D
+relationship: has_part HGNC:9192 ! POLR2E
+relationship: has_part HGNC:9193 ! POLR2F
+relationship: has_part HGNC:9194 ! POLR2G
+relationship: has_part HGNC:9195 ! POLR2H
+relationship: has_part HGNC:9196 ! POLR2I
+relationship: has_part HGNC:9197 ! POLR2J
+relationship: has_part HGNC:23208 ! POLR2J2
+relationship: has_part HGNC:9198 ! POLR2K
+relationship: has_part HGNC:9199 ! POLR2L
+
+[Term]
+id: FPLX:000418
 name: ROBO
 xref: SIGNOR:SIGNOR-PF14
-is_a: FPLX:root
-inverse_is_a: HGNC:ROBO1
-inverse_is_a: HGNC:ROBO2
-inverse_is_a: HGNC:ROBO3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10249 ! ROBO1
+relationship: inverse_is_a HGNC:10250 ! ROBO2
+relationship: inverse_is_a HGNC:13433 ! ROBO3
 
 [Term]
-id: FPLX:ROCK
+id: FPLX:000419
 name: ROCK
 synonym: "ROCK" EXACT []
 xref: BEL:"ROCK Family"
@@ -7092,12 +7112,12 @@ xref: IP:IPR015008
 xref: IP:IPR020684
 xref: RE:R-HSA-419057
 xref: RE:R-HSA-4687776
-is_a: FPLX:root
-inverse_is_a: HGNC:ROCK1
-inverse_is_a: HGNC:ROCK2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10251 ! ROCK1
+relationship: inverse_is_a HGNC:10252 ! ROCK2
 
 [Term]
-id: FPLX:ROR
+id: FPLX:000420
 name: ROR
 synonym: "receptor tyrosine kinase-like orphan receptor" EXACT []
 synonym: "receptor tyrosine kinase-like orphan receptors" EXACT []
@@ -7107,39 +7127,39 @@ xref: BEL:"ROR Family"
 xref: IP:IPR016247
 xref: MEDSCAN:urn:agi-aopfc:0000286
 xref: NEXTPROT-FAMILY:03130
-is_a: FPLX:root
-inverse_is_a: HGNC:ROR1
-inverse_is_a: HGNC:ROR2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10256 ! ROR1
+relationship: inverse_is_a HGNC:10257 ! ROR2
 
 [Term]
-id: FPLX:RPA
+id: FPLX:000421
 name: RPA
 synonym: "Replication protein A" EXACT []
 synonym: "replication protein A" EXACT []
 synonym: "RPA" EXACT []
 xref: RE:R-HSA-68462
-is_a: FPLX:root
-has_part: HGNC:RPA1
-has_part: HGNC:RPA2
-has_part: HGNC:RPA3
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:10289 ! RPA1
+relationship: has_part HGNC:10290 ! RPA2
+relationship: has_part HGNC:10291 ! RPA3
 
 [Term]
-id: FPLX:RSK
+id: FPLX:000422
 name: RSK
 synonym: "RSK" EXACT []
-is_a: FPLX:root
-inverse_is_a: FPLX:P90RSK
-inverse_is_a: FPLX:P70S6K
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000329 ! P90RSK
+relationship: inverse_is_a FPLX:000328 ! P70S6K
 
 [Term]
-id: FPLX:RTK
+id: FPLX:000423
 name: RTK
 synonym: "RTKs" EXACT []
 xref: NCIT:C17660
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:RXR
+id: FPLX:000424
 name: RXR
 synonym: "retinoid X receptors" EXACT []
 synonym: "retinoid-X receptor" EXACT []
@@ -7148,50 +7168,50 @@ xref: BEL:"RXR Family"
 xref: GO:0004886
 xref: MEDSCAN:urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422
 xref: NCIT:C17534
-is_a: FPLX:root
-inverse_is_a: HGNC:RXRA
-inverse_is_a: HGNC:RXRB
-inverse_is_a: HGNC:RXRG
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10477 ! RXRA
+relationship: inverse_is_a HGNC:10478 ! RXRB
+relationship: inverse_is_a HGNC:10479 ! RXRG
 
 [Term]
-id: FPLX:S100
+id: FPLX:000425
 name: S100
 synonym: "S100" EXACT []
-is_a: FPLX:root
-inverse_is_a: FPLX:S100A
-inverse_is_a: HGNC:S100B
-inverse_is_a: HGNC:S100G
-inverse_is_a: HGNC:S100P
-inverse_is_a: HGNC:S100Z
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000426 ! S100A
+relationship: inverse_is_a HGNC:10500 ! S100B
+relationship: inverse_is_a HGNC:1436 ! S100G
+relationship: inverse_is_a HGNC:10504 ! S100P
+relationship: inverse_is_a HGNC:30367 ! S100Z
 
 [Term]
-id: FPLX:S100A
+id: FPLX:000426
 name: S100A
 synonym: "S100A" EXACT []
 synonym: "S100a" EXACT []
 xref: BEL:"S100A Family"
-is_a: FPLX:S100
-inverse_is_a: HGNC:HRNR
-inverse_is_a: HGNC:S100A1
-inverse_is_a: HGNC:S100A10
-inverse_is_a: HGNC:S100A11
-inverse_is_a: HGNC:S100A12
-inverse_is_a: HGNC:S100A13
-inverse_is_a: HGNC:S100A14
-inverse_is_a: HGNC:S100A16
-inverse_is_a: HGNC:S100A2
-inverse_is_a: HGNC:S100A3
-inverse_is_a: HGNC:S100A4
-inverse_is_a: HGNC:S100A5
-inverse_is_a: HGNC:S100A6
-inverse_is_a: HGNC:S100A7
-inverse_is_a: HGNC:S100A7A
-inverse_is_a: HGNC:S100A8
-inverse_is_a: HGNC:S100A9
-inverse_is_a: HGNC:TCHHL1
-
-[Term]
-id: FPLX:S1PR
+is_a: FPLX:000425 ! S100
+relationship: inverse_is_a HGNC:20846 ! HRNR
+relationship: inverse_is_a HGNC:10486 ! S100A1
+relationship: inverse_is_a HGNC:10487 ! S100A10
+relationship: inverse_is_a HGNC:10488 ! S100A11
+relationship: inverse_is_a HGNC:10489 ! S100A12
+relationship: inverse_is_a HGNC:10490 ! S100A13
+relationship: inverse_is_a HGNC:18901 ! S100A14
+relationship: inverse_is_a HGNC:20441 ! S100A16
+relationship: inverse_is_a HGNC:10492 ! S100A2
+relationship: inverse_is_a HGNC:10493 ! S100A3
+relationship: inverse_is_a HGNC:10494 ! S100A4
+relationship: inverse_is_a HGNC:10495 ! S100A5
+relationship: inverse_is_a HGNC:10496 ! S100A6
+relationship: inverse_is_a HGNC:10497 ! S100A7
+relationship: inverse_is_a HGNC:21657 ! S100A7A
+relationship: inverse_is_a HGNC:10498 ! S100A8
+relationship: inverse_is_a HGNC:10499 ! S100A9
+relationship: inverse_is_a HGNC:31796 ! TCHHL1
+
+[Term]
+id: FPLX:000427
 name: S1PR
 synonym: "S1P receptor" EXACT []
 synonym: "S1PR" EXACT []
@@ -7202,28 +7222,28 @@ xref: GO:0038036
 xref: IP:IPR004061
 xref: RE:R-HSA-419346
 xref: RE:R-HSA-419401
-is_a: FPLX:root
-inverse_is_a: HGNC:S1PR1
-inverse_is_a: HGNC:S1PR2
-inverse_is_a: HGNC:S1PR3
-inverse_is_a: HGNC:S1PR4
-inverse_is_a: HGNC:S1PR5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3165 ! S1PR1
+relationship: inverse_is_a HGNC:3169 ! S1PR2
+relationship: inverse_is_a HGNC:3167 ! S1PR3
+relationship: inverse_is_a HGNC:3170 ! S1PR4
+relationship: inverse_is_a HGNC:14299 ! S1PR5
 
 [Term]
-id: FPLX:SAA
+id: FPLX:000428
 name: SAA
 synonym: "SAA" EXACT []
 xref: BEL:"SAA Family"
 xref: IP:IPR000096
 xref: NEXTPROT-FAMILY:03483
 xref: XFAM:PF00277
-is_a: FPLX:root
-inverse_is_a: HGNC:SAA1
-inverse_is_a: HGNC:SAA2
-inverse_is_a: HGNC:SAA4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10513 ! SAA1
+relationship: inverse_is_a HGNC:10514 ! SAA2
+relationship: inverse_is_a HGNC:10516 ! SAA4
 
 [Term]
-id: FPLX:SCD
+id: FPLX:000429
 name: SCD
 synonym: "stearoyl-CoA 9-desaturase" EXACT []
 synonym: "Stearoyl-CoA desaturase" EXACT []
@@ -7232,12 +7252,12 @@ xref: BEL:"SCD Family"
 xref: ECCODE:1.14.19.1
 xref: IP:IPR001522
 xref: IP:IPR015876
-is_a: FPLX:root
-inverse_is_a: HGNC:SCD
-inverse_is_a: HGNC:SCD5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10571 ! SCD
+relationship: inverse_is_a HGNC:21088 ! SCD5
 
 [Term]
-id: FPLX:SERCA
+id: FPLX:000430
 name: SERCA
 synonym: "sarcoplasmic/endoplasmic reticulum calcium ATPase" EXACT []
 synonym: "SERCA" EXACT []
@@ -7248,36 +7268,36 @@ xref: IP:IPR005782
 xref: MEDSCAN:urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase
 xref: RE:R-HSA-418312
 xref: RE:R-HSA-427905
-is_a: FPLX:root
-inverse_is_a: HGNC:ATP2A1
-inverse_is_a: HGNC:ATP2A2
-inverse_is_a: HGNC:ATP2A3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:811 ! ATP2A1
+relationship: inverse_is_a HGNC:812 ! ATP2A2
+relationship: inverse_is_a HGNC:813 ! ATP2A3
 
 [Term]
-id: FPLX:SERPINB
+id: FPLX:000431
 name: SERPINB
 synonym: "Clade B serpin" EXACT []
 synonym: "clade B serpins" EXACT []
 synonym: "ov-serpins" EXACT []
 xref: BEL:"SERPINB Family"
 xref: NEXTPROT-FAMILY:03579
-is_a: FPLX:root
-inverse_is_a: HGNC:SERPINB1
-inverse_is_a: HGNC:SERPINB2
-inverse_is_a: HGNC:SERPINB3
-inverse_is_a: HGNC:SERPINB4
-inverse_is_a: HGNC:SERPINB5
-inverse_is_a: HGNC:SERPINB6
-inverse_is_a: HGNC:SERPINB7
-inverse_is_a: HGNC:SERPINB8
-inverse_is_a: HGNC:SERPINB9
-inverse_is_a: HGNC:SERPINB10
-inverse_is_a: HGNC:SERPINB11
-inverse_is_a: HGNC:SERPINB12
-inverse_is_a: HGNC:SERPINB13
-
-[Term]
-id: FPLX:SHC
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3311 ! SERPINB1
+relationship: inverse_is_a HGNC:8584 ! SERPINB2
+relationship: inverse_is_a HGNC:10569 ! SERPINB3
+relationship: inverse_is_a HGNC:10570 ! SERPINB4
+relationship: inverse_is_a HGNC:8949 ! SERPINB5
+relationship: inverse_is_a HGNC:8950 ! SERPINB6
+relationship: inverse_is_a HGNC:13902 ! SERPINB7
+relationship: inverse_is_a HGNC:8952 ! SERPINB8
+relationship: inverse_is_a HGNC:8955 ! SERPINB9
+relationship: inverse_is_a HGNC:8942 ! SERPINB10
+relationship: inverse_is_a HGNC:14221 ! SERPINB11
+relationship: inverse_is_a HGNC:14220 ! SERPINB12
+relationship: inverse_is_a HGNC:8944 ! SERPINB13
+
+[Term]
+id: FPLX:000432
 name: SHC
 synonym: "Shc family" EXACT []
 synonym: "SHC" EXACT []
@@ -7285,24 +7305,24 @@ synonym: "Shc" EXACT []
 xref: IP:IPR006019
 xref: MEDSCAN:urn:agi-protfc:shc%20protein
 xref: RE:R-HSA-167023
-is_a: FPLX:root
-inverse_is_a: HGNC:SHC1
-inverse_is_a: HGNC:SHC2
-inverse_is_a: HGNC:SHC3
-inverse_is_a: HGNC:SHC4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10840 ! SHC1
+relationship: inverse_is_a HGNC:29869 ! SHC2
+relationship: inverse_is_a HGNC:18181 ! SHC3
+relationship: inverse_is_a HGNC:16743 ! SHC4
 
 [Term]
-id: FPLX:SIK
+id: FPLX:000433
 name: SIK
 synonym: "SIK" EXACT []
 synonym: "salt inducible kinase" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:SIK1
-inverse_is_a: HGNC:SIK2
-inverse_is_a: HGNC:SIK3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11142 ! SIK1
+relationship: inverse_is_a HGNC:21680 ! SIK2
+relationship: inverse_is_a HGNC:29165 ! SIK3
 
 [Term]
-id: FPLX:SLC2A
+id: FPLX:000434
 name: SLC2A
 synonym: "glucose transporter" EXACT []
 synonym: "glucose transporters" EXACT []
@@ -7311,23 +7331,23 @@ synonym: "SLC2" EXACT []
 xref: BEL:"SLC2A Family"
 xref: GO:0005355
 xref: NEXTPROT-FAMILY:02159
-is_a: FPLX:root
-inverse_is_a: HGNC:SLC2A1
-inverse_is_a: HGNC:SLC2A2
-inverse_is_a: HGNC:SLC2A3
-inverse_is_a: HGNC:SLC2A4
-inverse_is_a: HGNC:SLC2A5
-inverse_is_a: HGNC:SLC2A6
-inverse_is_a: HGNC:SLC2A7
-inverse_is_a: HGNC:SLC2A8
-inverse_is_a: HGNC:SLC2A9
-inverse_is_a: HGNC:SLC2A10
-inverse_is_a: HGNC:SLC2A11
-inverse_is_a: HGNC:SLC2A12
-inverse_is_a: HGNC:SLC2A14
-
-[Term]
-id: FPLX:SLRP
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11005 ! SLC2A1
+relationship: inverse_is_a HGNC:11006 ! SLC2A2
+relationship: inverse_is_a HGNC:11007 ! SLC2A3
+relationship: inverse_is_a HGNC:11009 ! SLC2A4
+relationship: inverse_is_a HGNC:11010 ! SLC2A5
+relationship: inverse_is_a HGNC:11011 ! SLC2A6
+relationship: inverse_is_a HGNC:13445 ! SLC2A7
+relationship: inverse_is_a HGNC:13812 ! SLC2A8
+relationship: inverse_is_a HGNC:13446 ! SLC2A9
+relationship: inverse_is_a HGNC:13444 ! SLC2A10
+relationship: inverse_is_a HGNC:14239 ! SLC2A11
+relationship: inverse_is_a HGNC:18067 ! SLC2A12
+relationship: inverse_is_a HGNC:18301 ! SLC2A14
+
+[Term]
+id: FPLX:000435
 name: SLRP
 synonym: "SLRP" EXACT []
 synonym: "SLRPs" EXACT []
@@ -7341,62 +7361,62 @@ synonym: "small leucine-rich proteoglycan" EXACT []
 synonym: "small leucine-rich proteoglycans" EXACT []
 xref: NEXTPROT-FAMILY:03672
 xref: SIGNOR:SIGNOR-PF31
-is_a: FPLX:root
-inverse_is_a: FPLX:SLRP_1
-inverse_is_a: FPLX:SLRP_2
-inverse_is_a: FPLX:SLRP_3
-inverse_is_a: FPLX:SLRP_4
-inverse_is_a: FPLX:SLRP_5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000436 ! SLRP_1
+relationship: inverse_is_a FPLX:000437 ! SLRP_2
+relationship: inverse_is_a FPLX:000438 ! SLRP_3
+relationship: inverse_is_a FPLX:000439 ! SLRP_4
+relationship: inverse_is_a FPLX:000440 ! SLRP_5
 
 [Term]
-id: FPLX:SLRP_1
+id: FPLX:000436
 name: SLRP-1
 xref: NEXTPROT-FAMILY:03673
-is_a: FPLX:SLRP
-inverse_is_a: HGNC:BGN
-inverse_is_a: HGNC:DCN
-inverse_is_a: HGNC:ASPN
-inverse_is_a: HGNC:ECM2
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:1044 ! BGN
+relationship: inverse_is_a HGNC:2705 ! DCN
+relationship: inverse_is_a HGNC:14872 ! ASPN
+relationship: inverse_is_a HGNC:3154 ! ECM2
 
 [Term]
-id: FPLX:SLRP_2
+id: FPLX:000437
 name: SLRP-2
 xref: NEXTPROT-FAMILY:03674
-is_a: FPLX:SLRP
-inverse_is_a: HGNC:FMOD
-inverse_is_a: HGNC:LUM
-inverse_is_a: HGNC:PRELP
-inverse_is_a: HGNC:KERA
-inverse_is_a: HGNC:OMD
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:3774 ! FMOD
+relationship: inverse_is_a HGNC:6724 ! LUM
+relationship: inverse_is_a HGNC:9357 ! PRELP
+relationship: inverse_is_a HGNC:6309 ! KERA
+relationship: inverse_is_a HGNC:8134 ! OMD
 
 [Term]
-id: FPLX:SLRP_3
+id: FPLX:000438
 name: SLRP-3
 xref: NEXTPROT-FAMILY:03675
-is_a: FPLX:SLRP
-inverse_is_a: HGNC:EPYC
-inverse_is_a: HGNC:OPTC
-inverse_is_a: HGNC:OGN
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:3053 ! EPYC
+relationship: inverse_is_a HGNC:8158 ! OPTC
+relationship: inverse_is_a HGNC:8126 ! OGN
 
 [Term]
-id: FPLX:SLRP_4
+id: FPLX:000439
 name: SLRP-4
 xref: NEXTPROT-FAMILY:03676
-is_a: FPLX:SLRP
-inverse_is_a: HGNC:CHAD
-inverse_is_a: HGNC:NYX
-inverse_is_a: HGNC:TSKU
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:1909 ! CHAD
+relationship: inverse_is_a HGNC:8082 ! NYX
+relationship: inverse_is_a HGNC:28850 ! TSKU
 
 [Term]
-id: FPLX:SLRP_5
+id: FPLX:000440
 name: SLRP-5
 xref: NEXTPROT-FAMILY:03677
-is_a: FPLX:SLRP
-inverse_is_a: HGNC:PODN
-inverse_is_a: HGNC:PODNL1
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:23174 ! PODN
+relationship: inverse_is_a HGNC:26275 ! PODNL1
 
 [Term]
-id: FPLX:SMAD
+id: FPLX:000441
 name: SMAD
 synonym: "SMAD" EXACT []
 synonym: "Smad" EXACT []
@@ -7407,27 +7427,27 @@ xref: IP:IPR013019
 xref: IP:IPR013790
 xref: MEDSCAN:urn:agi-aopfc:0000159
 xref: MEDSCAN:urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28
-is_a: FPLX:root
-inverse_is_a: HGNC:SMAD1
-inverse_is_a: HGNC:SMAD4
-inverse_is_a: HGNC:SMAD5
-inverse_is_a: HGNC:SMAD6
-inverse_is_a: HGNC:SMAD7
-inverse_is_a: HGNC:SMAD9
-inverse_is_a: FPLX:SMAD2_3
-inverse_is_a: FPLX:SMAD1_5_9
-
-[Term]
-id: FPLX:SMAD1_5_9
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6767 ! SMAD1
+relationship: inverse_is_a HGNC:6770 ! SMAD4
+relationship: inverse_is_a HGNC:6771 ! SMAD5
+relationship: inverse_is_a HGNC:6772 ! SMAD6
+relationship: inverse_is_a HGNC:6773 ! SMAD7
+relationship: inverse_is_a HGNC:6774 ! SMAD9
+relationship: inverse_is_a FPLX:000443 ! SMAD2_3
+relationship: inverse_is_a FPLX:000442 ! SMAD1_5_9
+
+[Term]
+id: FPLX:000442
 name: SMAD1-5-9
 xref: SIGNOR:SIGNOR-PF35
-is_a: FPLX:SMAD
-inverse_is_a: HGNC:SMAD1
-inverse_is_a: HGNC:SMAD5
-inverse_is_a: HGNC:SMAD9
+is_a: FPLX:000441 ! SMAD
+relationship: inverse_is_a HGNC:6767 ! SMAD1
+relationship: inverse_is_a HGNC:6771 ! SMAD5
+relationship: inverse_is_a HGNC:6774 ! SMAD9
 
 [Term]
-id: FPLX:SMAD2_3
+id: FPLX:000443
 name: SMAD2-3
 synonym: "SMAD 2/3" EXACT []
 synonym: "SMAD2/3" EXACT []
@@ -7439,83 +7459,83 @@ xref: RE:R-HSA-177105
 xref: RE:R-HSA-2176482
 xref: RE:R-HSA-2187329
 xref: RE:R-HSA-2187387
-is_a: FPLX:SMAD
-inverse_is_a: HGNC:SMAD2
-inverse_is_a: HGNC:SMAD3
+is_a: FPLX:000441 ! SMAD
+relationship: inverse_is_a HGNC:6768 ! SMAD2
+relationship: inverse_is_a HGNC:6769 ! SMAD3
 
 [Term]
-id: FPLX:SMC1
+id: FPLX:000444
 name: SMC1
 synonym: "SMC1" EXACT []
 synonym: "Smc1" EXACT []
 xref: BEL:"SMC1 Family"
 xref: NEXTPROT-FAMILY:03686
-is_a: FPLX:root
-inverse_is_a: HGNC:SMC1A
-inverse_is_a: HGNC:SMC1B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11111 ! SMC1A
+relationship: inverse_is_a HGNC:11112 ! SMC1B
 
 [Term]
-id: FPLX:SMURF
+id: FPLX:000445
 name: SMURF
 xref: SIGNOR:SIGNOR-PF29
-is_a: FPLX:root
-inverse_is_a: HGNC:SMURF1
-inverse_is_a: HGNC:SMURF2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:16807 ! SMURF1
+relationship: inverse_is_a HGNC:16809 ! SMURF2
 
 [Term]
-id: FPLX:SNAI
+id: FPLX:000446
 name: SNAI
 synonym: "SNAI family" EXACT []
 synonym: "SNAI" EXACT []
 xref: BEL:"SNAI Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:SNAI1
-inverse_is_a: HGNC:SNAI2
-inverse_is_a: HGNC:SNAI3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11128 ! SNAI1
+relationship: inverse_is_a HGNC:11094 ! SNAI2
+relationship: inverse_is_a HGNC:18411 ! SNAI3
 
 [Term]
-id: FPLX:SOD
+id: FPLX:000447
 name: SOD
 synonym: "SOD" EXACT []
 xref: BEL:"Cu-Zn SOD Family"
-is_a: FPLX:root
-inverse_is_a: HGNC:SOD1
-inverse_is_a: HGNC:SOD2
-inverse_is_a: HGNC:SOD3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11179 ! SOD1
+relationship: inverse_is_a HGNC:11180 ! SOD2
+relationship: inverse_is_a HGNC:11181 ! SOD3
 
 [Term]
-id: FPLX:SOS
+id: FPLX:000448
 name: SOS
 synonym: "SOS" EXACT []
 xref: BEL:"SOS Family"
 xref: RE:R-HSA-167215
-is_a: FPLX:root
-inverse_is_a: HGNC:SOS1
-inverse_is_a: HGNC:SOS2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11187 ! SOS1
+relationship: inverse_is_a HGNC:11188 ! SOS2
 
 [Term]
-id: FPLX:SPRED
+id: FPLX:000449
 name: SPRED
 synonym: "SPRED" EXACT []
 xref: IP:IPR023337
 xref: RE:R-HSA-5658219
-is_a: FPLX:root
-inverse_is_a: HGNC:SPRED1
-inverse_is_a: HGNC:SPRED2
-inverse_is_a: HGNC:SPRED3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:20249 ! SPRED1
+relationship: inverse_is_a HGNC:17722 ! SPRED2
+relationship: inverse_is_a HGNC:31041 ! SPRED3
 
 [Term]
-id: FPLX:SPRY
+id: FPLX:000450
 name: SPRY
 synonym: "SPRY" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:SPRY1
-inverse_is_a: HGNC:SPRY2
-inverse_is_a: HGNC:SPRY3
-inverse_is_a: HGNC:SPRY4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11269 ! SPRY1
+relationship: inverse_is_a HGNC:11270 ! SPRY2
+relationship: inverse_is_a HGNC:11271 ! SPRY3
+relationship: inverse_is_a HGNC:15533 ! SPRY4
 
 [Term]
-id: FPLX:SRC
+id: FPLX:000451
 name: SRC
 synonym: "SFK" EXACT []
 synonym: "Src family kinase" EXACT []
@@ -7527,14 +7547,14 @@ xref: BEL:"SRC Family"
 xref: MEDSCAN:urn:agi-aopfc:0000509
 xref: NEXTPROT-FAMILY:03131
 xref: SIGNOR:SIGNOR-PF32
-is_a: FPLX:root
-inverse_is_a: HGNC:FGR
-inverse_is_a: HGNC:FYN
-inverse_is_a: HGNC:SRC
-inverse_is_a: HGNC:YES1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3697 ! FGR
+relationship: inverse_is_a HGNC:4037 ! FYN
+relationship: inverse_is_a HGNC:11283 ! SRC
+relationship: inverse_is_a HGNC:12841 ! YES1
 
 [Term]
-id: FPLX:SREBF
+id: FPLX:000452
 name: SREBF
 synonym: "SREBF family" EXACT []
 synonym: "SREBF" EXACT []
@@ -7548,12 +7568,12 @@ xref: RE:R-HSA-1655726
 xref: RE:R-HSA-1655730
 xref: RE:R-HSA-1655732
 xref: RE:R-HSA-1655734
-is_a: FPLX:root
-inverse_is_a: HGNC:SREBF1
-inverse_is_a: HGNC:SREBF2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11289 ! SREBF1
+relationship: inverse_is_a HGNC:11290 ! SREBF2
 
 [Term]
-id: FPLX:STAT
+id: FPLX:000453
 name: STAT
 synonym: "STAT" EXACT []
 synonym: "STATs" EXACT []
@@ -7567,16 +7587,16 @@ xref: IP:IPR015988
 xref: MEDSCAN:urn:agi-aopfc:0000163
 xref: MEDSCAN:urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15
 xref: NCIT:C19618
-is_a: FPLX:root
-inverse_is_a: HGNC:STAT1
-inverse_is_a: HGNC:STAT2
-inverse_is_a: HGNC:STAT3
-inverse_is_a: HGNC:STAT4
-inverse_is_a: HGNC:STAT6
-inverse_is_a: FPLX:STAT5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11362 ! STAT1
+relationship: inverse_is_a HGNC:11363 ! STAT2
+relationship: inverse_is_a HGNC:11364 ! STAT3
+relationship: inverse_is_a HGNC:11365 ! STAT4
+relationship: inverse_is_a HGNC:11368 ! STAT6
+relationship: inverse_is_a FPLX:000454 ! STAT5
 
 [Term]
-id: FPLX:STAT5
+id: FPLX:000454
 name: STAT5
 synonym: "STAT5" EXACT []
 synonym: "Stat5" EXACT []
@@ -7588,20 +7608,20 @@ xref: RE:R-HSA-507919
 xref: RE:R-HSA-507929
 xref: RE:R-HSA-508012
 xref: RE:R-HSA-8865622
-is_a: FPLX:STAT
-inverse_is_a: HGNC:STAT5A
-inverse_is_a: HGNC:STAT5B
+is_a: FPLX:000453 ! STAT
+relationship: inverse_is_a HGNC:11366 ! STAT5A
+relationship: inverse_is_a HGNC:11367 ! STAT5B
 
 [Term]
-id: FPLX:STT3
+id: FPLX:000455
 name: STT3
 synonym: "STT3" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:STT3A
-inverse_is_a: HGNC:STT3B
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:6172 ! STT3A
+relationship: inverse_is_a HGNC:30611 ! STT3B
 
 [Term]
-id: FPLX:Sulfonylurea_receptor
+id: FPLX:000456
 name: Sulfonylurea-receptor
 synonym: "Sulfonylurea Receptor" EXACT []
 synonym: "sulfonylurea receptor" EXACT []
@@ -7610,12 +7630,12 @@ synonym: "SUR" EXACT []
 xref: BEL:"Sulfonylurea Receptor Family"
 xref: GO:0008281
 xref: IP:IPR000388
-is_a: FPLX:root
-inverse_is_a: HGNC:ABCC8
-inverse_is_a: HGNC:ABCC9
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:59 ! ABCC8
+relationship: inverse_is_a HGNC:60 ! ABCC9
 
 [Term]
-id: FPLX:SWI_SNF
+id: FPLX:000457
 name: SWI-SNF
 synonym: "SWI and SNF complex" EXACT []
 synonym: "SWI/SNF complex" EXACT []
@@ -7626,47 +7646,47 @@ xref: MEDSCAN:urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861
 xref: MEDSCAN:urn:agi-protfc:chromatin%20remodeling%20complex
 xref: MEDSCAN:urn:agi-protfc:SWI%2fSNF%20family
 xref: NCIT:C20591
-is_a: FPLX:root
-has_part: HGNC:ARID1A
-has_part: HGNC:ARID1B
-has_part: HGNC:SMARCA1
-has_part: HGNC:SMARCA2
-has_part: HGNC:SMARCA4
-has_part: HGNC:SMARCA5
-has_part: HGNC:SMARCB1
-has_part: HGNC:SMARCC1
-has_part: HGNC:SMARCC2
-has_part: HGNC:SMARCD1
-has_part: HGNC:SMARCD2
-has_part: HGNC:SMARCD3
-has_part: HGNC:SMARCE1
-has_part: HGNC:ACTL6A
-has_part: HGNC:ACTL6B
-has_part: HGNC:HLTF
-
-[Term]
-id: FPLX:TAOK
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:11110 ! ARID1A
+relationship: has_part HGNC:18040 ! ARID1B
+relationship: has_part HGNC:11097 ! SMARCA1
+relationship: has_part HGNC:11098 ! SMARCA2
+relationship: has_part HGNC:11100 ! SMARCA4
+relationship: has_part HGNC:11101 ! SMARCA5
+relationship: has_part HGNC:11103 ! SMARCB1
+relationship: has_part HGNC:11104 ! SMARCC1
+relationship: has_part HGNC:11105 ! SMARCC2
+relationship: has_part HGNC:11106 ! SMARCD1
+relationship: has_part HGNC:11107 ! SMARCD2
+relationship: has_part HGNC:11108 ! SMARCD3
+relationship: has_part HGNC:11109 ! SMARCE1
+relationship: has_part HGNC:24124 ! ACTL6A
+relationship: has_part HGNC:160 ! ACTL6B
+relationship: has_part HGNC:11099 ! HLTF
+
+[Term]
+id: FPLX:000458
 name: TAOK
 xref: SIGNOR:SIGNOR-PF21
-is_a: FPLX:MAP3K
-inverse_is_a: HGNC:TAOK1
-inverse_is_a: HGNC:TAOK2
-inverse_is_a: HGNC:TAOK3
+is_a: FPLX:000282 ! MAP3K
+relationship: inverse_is_a HGNC:29259 ! TAOK1
+relationship: inverse_is_a HGNC:16835 ! TAOK2
+relationship: inverse_is_a HGNC:18133 ! TAOK3
 
 [Term]
-id: FPLX:TAP
+id: FPLX:000459
 name: TAP
 synonym: "TAP transporter" EXACT []
 synonym: "TAP" EXACT []
 xref: BEL:"TAP Family"
 xref: GO:0042825
-is_a: FPLX:root
-inverse_is_a: HGNC:TAP1
-inverse_is_a: HGNC:TAP2
-inverse_is_a: HGNC:ABCB9
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:43 ! TAP1
+relationship: inverse_is_a HGNC:44 ! TAP2
+relationship: inverse_is_a HGNC:50 ! ABCB9
 
 [Term]
-id: FPLX:TCF_LEF
+id: FPLX:000460
 name: TCF-LEF
 synonym: "T-cell factor (TCF)/lymphoid enhancer factor" EXACT []
 synonym: "TCF" EXACT []
@@ -7680,36 +7700,36 @@ xref: RE:R-HSA-3299546
 xref: RE:R-HSA-5323539
 xref: RE:R-HSA-8944354
 xref: RE:R-HSA-8951427
-is_a: FPLX:root
-inverse_is_a: HGNC:LEF1
-inverse_is_a: HGNC:TCF7
-inverse_is_a: HGNC:TCF7L1
-inverse_is_a: HGNC:TCF7L2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6551 ! LEF1
+relationship: inverse_is_a HGNC:11639 ! TCF7
+relationship: inverse_is_a HGNC:11640 ! TCF7L1
+relationship: inverse_is_a HGNC:11641 ! TCF7L2
 
 [Term]
-id: FPLX:TCR
+id: FPLX:000461
 name: TCR
 synonym: "TCR" EXACT []
 xref: MESH:D011948
 xref: NCIT:C17065
-is_a: FPLX:root
-has_part: HGNC:TRA
-has_part: HGNC:TRB
-has_part: HGNC:TRD
-has_part: HGNC:TRG
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:12027 ! TRA
+relationship: has_part HGNC:12155 ! TRB
+relationship: has_part HGNC:12252 ! TRD
+relationship: has_part HGNC:12271 ! TRG
 
 [Term]
-id: FPLX:TEAD
+id: FPLX:000462
 name: TEAD
 xref: SIGNOR:SIGNOR-PF22
-is_a: FPLX:root
-inverse_is_a: HGNC:TEAD1
-inverse_is_a: HGNC:TEAD2
-inverse_is_a: HGNC:TEAD3
-inverse_is_a: HGNC:TEAD4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11714 ! TEAD1
+relationship: inverse_is_a HGNC:11715 ! TEAD2
+relationship: inverse_is_a HGNC:11716 ! TEAD3
+relationship: inverse_is_a HGNC:11717 ! TEAD4
 
 [Term]
-id: FPLX:TFAP2
+id: FPLX:000463
 name: TFAP2
 synonym: "AP-2 transcription factor" EXACT []
 synonym: "Transcription factor AP-2" EXACT []
@@ -7720,27 +7740,27 @@ xref: IP:IPR013854
 xref: NEXTPROT-FAMILY:00209
 xref: RE:R-HSA-8864283
 xref: RE:R-HSA-8864286
-is_a: FPLX:root
-inverse_is_a: HGNC:TFAP2A
-inverse_is_a: HGNC:TFAP2B
-inverse_is_a: HGNC:TFAP2C
-inverse_is_a: HGNC:TFAP2D
-inverse_is_a: HGNC:TFAP2E
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11742 ! TFAP2A
+relationship: inverse_is_a HGNC:11743 ! TFAP2B
+relationship: inverse_is_a HGNC:11744 ! TFAP2C
+relationship: inverse_is_a HGNC:15581 ! TFAP2D
+relationship: inverse_is_a HGNC:30774 ! TFAP2E
 
 [Term]
-id: FPLX:TFDP
+id: FPLX:000464
 name: TFDP
 synonym: "DP complex" EXACT []
 synonym: "TFDP" EXACT []
 synonym: "transcription factor DP" EXACT []
 xref: BEL:"TFDP Family"
 xref: RE:R-HSA-1362227
-is_a: FPLX:root
-inverse_is_a: HGNC:TFDP1
-inverse_is_a: HGNC:TFDP2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11749 ! TFDP1
+relationship: inverse_is_a HGNC:11751 ! TFDP2
 
 [Term]
-id: FPLX:TGFB
+id: FPLX:000465
 name: TGFB
 synonym: "TGF beta" EXACT []
 synonym: "TGF β" EXACT []
@@ -7764,13 +7784,13 @@ xref: NEXTPROT-FAMILY:03989
 xref: RE:R-HSA-114657
 xref: RE:R-HSA-2395330
 xref: SIGNOR:SIGNOR-PF5
-is_a: FPLX:root
-inverse_is_a: HGNC:TGFB1
-inverse_is_a: HGNC:TGFB2
-inverse_is_a: HGNC:TGFB3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11766 ! TGFB1
+relationship: inverse_is_a HGNC:11768 ! TGFB2
+relationship: inverse_is_a HGNC:11769 ! TGFB3
 
 [Term]
-id: FPLX:TGFBR
+id: FPLX:000466
 name: TGFBR
 synonym: "TGF beta receptor" EXACT []
 synonym: "TGF β receptor" EXACT []
@@ -7784,13 +7804,13 @@ synonym: "TGFβ receptor" EXACT []
 synonym: "TGFβ receptors" EXACT []
 xref: MEDSCAN:urn:agi-aopfc:0000294
 xref: MEDSCAN:urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6
-is_a: FPLX:root
-inverse_is_a: HGNC:TGFBR1
-inverse_is_a: HGNC:TGFBR2
-inverse_is_a: HGNC:TGFBR3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11772 ! TGFBR1
+relationship: inverse_is_a HGNC:11773 ! TGFBR2
+relationship: inverse_is_a HGNC:11774 ! TGFBR3
 
 [Term]
-id: FPLX:THBS
+id: FPLX:000467
 name: THBS
 synonym: "thrombospondin protein" EXACT []
 synonym: "Thrombospondin" EXACT []
@@ -7803,75 +7823,75 @@ xref: IP:IPR008859
 xref: IP:IPR017897
 xref: IP:IPR028974
 xref: MEDSCAN:urn:agi-protfc:thrombospondins
-is_a: FPLX:root
-inverse_is_a: HGNC:THBS1
-inverse_is_a: HGNC:THBS2
-inverse_is_a: HGNC:THBS3
-inverse_is_a: HGNC:THBS4
-inverse_is_a: HGNC:COMP
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11785 ! THBS1
+relationship: inverse_is_a HGNC:11786 ! THBS2
+relationship: inverse_is_a HGNC:11787 ! THBS3
+relationship: inverse_is_a HGNC:11788 ! THBS4
+relationship: inverse_is_a HGNC:2227 ! COMP
 
 [Term]
-id: FPLX:THR
+id: FPLX:000468
 name: THR
 synonym: "thyroid hormone receptor" EXACT []
 xref: BEL:"THR Family"
 xref: NCIT:C17078
-is_a: FPLX:root
-inverse_is_a: HGNC:THRA
-inverse_is_a: HGNC:THRB
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11796 ! THRA
+relationship: inverse_is_a HGNC:11799 ! THRB
 
 [Term]
-id: FPLX:Thrombin_antithrombin
+id: FPLX:000469
 name: Thrombin-antithrombin
 synonym: "thrombin-anti-thrombin III complexes" EXACT []
 xref: BEL:"Thrombin Antithrombin Complex"
 xref: RE:R-HSA-140812
 xref: RE:R-HSA-140871
 xref: RE:R-HSA-140874
-is_a: FPLX:root
-has_part: HGNC:F2
-has_part: HGNC:SERPINC1
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3535 ! F2
+relationship: has_part HGNC:775 ! SERPINC1
 
 [Term]
-id: FPLX:TIAM
+id: FPLX:000470
 name: TIAM
 synonym: "TIAM" EXACT []
 xref: NEXTPROT-FAMILY:04014
-is_a: FPLX:root
-inverse_is_a: HGNC:TIAM1
-inverse_is_a: HGNC:TIAM2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11805 ! TIAM1
+relationship: inverse_is_a HGNC:11806 ! TIAM2
 
 [Term]
-id: FPLX:TIF_IB
+id: FPLX:000471
 name: TIF-IB
 synonym: "TIF-IB" EXACT []
 xref: BEL:"TIF IB Complex"
-is_a: FPLX:root
-has_part: HGNC:TAF1A
-has_part: HGNC:TAF1B
-has_part: HGNC:TAF1C
-has_part: HGNC:TBP
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:11532 ! TAF1A
+relationship: has_part HGNC:11533 ! TAF1B
+relationship: has_part HGNC:11534 ! TAF1C
+relationship: has_part HGNC:11588 ! TBP
 
 [Term]
-id: FPLX:TLR
+id: FPLX:000472
 name: TLR
 synonym: "TLR" EXACT []
 xref: MEDSCAN:urn:agi-aopfc:0000296
 xref: SIGNOR:SIGNOR-PF20
-is_a: FPLX:root
-inverse_is_a: HGNC:TLR1
-inverse_is_a: HGNC:TLR2
-inverse_is_a: HGNC:TLR3
-inverse_is_a: HGNC:TLR4
-inverse_is_a: HGNC:TLR5
-inverse_is_a: HGNC:TLR6
-inverse_is_a: HGNC:TLR7
-inverse_is_a: HGNC:TLR8
-inverse_is_a: HGNC:TLR9
-inverse_is_a: HGNC:TLR10
-
-[Term]
-id: FPLX:TN
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11847 ! TLR1
+relationship: inverse_is_a HGNC:11848 ! TLR2
+relationship: inverse_is_a HGNC:11849 ! TLR3
+relationship: inverse_is_a HGNC:11850 ! TLR4
+relationship: inverse_is_a HGNC:11851 ! TLR5
+relationship: inverse_is_a HGNC:16711 ! TLR6
+relationship: inverse_is_a HGNC:15631 ! TLR7
+relationship: inverse_is_a HGNC:15632 ! TLR8
+relationship: inverse_is_a HGNC:15633 ! TLR9
+relationship: inverse_is_a HGNC:15634 ! TLR10
+
+[Term]
+id: FPLX:000473
 name: TN
 synonym: "Tenascin" EXACT []
 synonym: "tenascin" EXACT []
@@ -7880,21 +7900,21 @@ xref: NCIT:C104676
 xref: NEXTPROT-FAMILY:03964
 xref: RE:R-HSA-2672035
 xref: RE:R-HSA-2681744
-is_a: FPLX:root
-inverse_is_a: HGNC:TNC
-inverse_is_a: HGNC:TNN
-inverse_is_a: HGNC:TNR
-inverse_is_a: HGNC:TNXB
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5318 ! TNC
+relationship: inverse_is_a HGNC:22942 ! TNN
+relationship: inverse_is_a HGNC:11953 ! TNR
+relationship: inverse_is_a HGNC:11976 ! TNXB
 
 [Term]
-id: FPLX:TNF
+id: FPLX:000474
 name: TNF
 xref: NEXTPROT-FAMILY:04243
 xref: XFAM:PF00229
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:TNFRSF
+id: FPLX:000475
 name: TNFRSF
 synonym: "TNF-R superfamily" EXACT []
 synonym: "TNF-receptor family" EXACT []
@@ -7906,30 +7926,30 @@ synonym: "TNFR superfamily" EXACT []
 synonym: "TNFR" EXACT []
 xref: BEL:"TNFRSF Family"
 xref: MEDSCAN:urn:agi-aopfc:0000295
-is_a: FPLX:root
-inverse_is_a: HGNC:TNFRSF1A
-inverse_is_a: HGNC:TNFRSF1B
-inverse_is_a: HGNC:TNFRSF4
-inverse_is_a: HGNC:TNFRSF8
-inverse_is_a: HGNC:TNFRSF9
-inverse_is_a: HGNC:TNFRSF10A
-inverse_is_a: HGNC:TNFRSF10B
-inverse_is_a: HGNC:TNFRSF10C
-inverse_is_a: HGNC:TNFRSF10D
-inverse_is_a: HGNC:TNFRSF11A
-inverse_is_a: HGNC:TNFRSF11B
-inverse_is_a: HGNC:TNFRSF12A
-inverse_is_a: HGNC:TNFRSF13B
-inverse_is_a: HGNC:TNFRSF13C
-inverse_is_a: HGNC:TNFRSF14
-inverse_is_a: HGNC:TNFRSF17
-inverse_is_a: HGNC:TNFRSF18
-inverse_is_a: HGNC:TNFRSF19
-inverse_is_a: HGNC:TNFRSF21
-inverse_is_a: HGNC:TNFRSF25
-
-[Term]
-id: FPLX:TOP2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11916 ! TNFRSF1A
+relationship: inverse_is_a HGNC:11917 ! TNFRSF1B
+relationship: inverse_is_a HGNC:11918 ! TNFRSF4
+relationship: inverse_is_a HGNC:11923 ! TNFRSF8
+relationship: inverse_is_a HGNC:11924 ! TNFRSF9
+relationship: inverse_is_a HGNC:11904 ! TNFRSF10A
+relationship: inverse_is_a HGNC:11905 ! TNFRSF10B
+relationship: inverse_is_a HGNC:11906 ! TNFRSF10C
+relationship: inverse_is_a HGNC:11907 ! TNFRSF10D
+relationship: inverse_is_a HGNC:11908 ! TNFRSF11A
+relationship: inverse_is_a HGNC:11909 ! TNFRSF11B
+relationship: inverse_is_a HGNC:18152 ! TNFRSF12A
+relationship: inverse_is_a HGNC:18153 ! TNFRSF13B
+relationship: inverse_is_a HGNC:17755 ! TNFRSF13C
+relationship: inverse_is_a HGNC:11912 ! TNFRSF14
+relationship: inverse_is_a HGNC:11913 ! TNFRSF17
+relationship: inverse_is_a HGNC:11914 ! TNFRSF18
+relationship: inverse_is_a HGNC:11915 ! TNFRSF19
+relationship: inverse_is_a HGNC:13469 ! TNFRSF21
+relationship: inverse_is_a HGNC:11910 ! TNFRSF25
+
+[Term]
+id: FPLX:000476
 name: TOP2
 synonym: "topoisomerase II" EXACT []
 xref: BEL:"TOP2 Family"
@@ -7947,12 +7967,12 @@ xref: IP:IPR024946
 xref: IP:IPR031660
 xref: IP:IPR034157
 xref: NCIT:C18434
-is_a: FPLX:root
-inverse_is_a: HGNC:TOP2A
-inverse_is_a: HGNC:TOP2B
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11989 ! TOP2A
+relationship: inverse_is_a HGNC:11990 ! TOP2B
 
 [Term]
-id: FPLX:Troponin
+id: FPLX:000477
 name: Troponin
 synonym: "troponin complex" EXACT []
 synonym: "troponin" EXACT []
@@ -7961,13 +7981,13 @@ xref: GO:0005861
 xref: MEDSCAN:urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086
 xref: RE:R-HSA-390583
 xref: RE:R-HSA-390585
-is_a: FPLX:root
-has_part: FPLX:Troponin_C
-has_part: FPLX:Troponin_I
-has_part: FPLX:Troponin_T
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000478 ! Troponin_C
+relationship: has_part FPLX:000479 ! Troponin_I
+relationship: has_part FPLX:000480 ! Troponin_T
 
 [Term]
-id: FPLX:Troponin_C
+id: FPLX:000478
 name: Troponin-C
 synonym: "cTnC" EXACT []
 synonym: "cTnI" EXACT []
@@ -7976,24 +7996,24 @@ synonym: "TnC" EXACT []
 synonym: "troponin C" EXACT []
 xref: RE:R-HSA-390532
 xref: RE:R-HSA-390587
-part_of: FPLX:Troponin
-inverse_is_a: HGNC:TNNC1
-inverse_is_a: HGNC:TNNC2
+relationship: part_of FPLX:000477 ! Troponin
+relationship: inverse_is_a HGNC:11943 ! TNNC1
+relationship: inverse_is_a HGNC:11944 ! TNNC2
 
 [Term]
-id: FPLX:Troponin_I
+id: FPLX:000479
 name: Troponin-I
 synonym: "TPNI" EXACT []
 synonym: "troponin I" EXACT []
 xref: NCIT:C17343
 xref: RE:R-HSA-390541
-part_of: FPLX:Troponin
-inverse_is_a: HGNC:TNNI1
-inverse_is_a: HGNC:TNNI2
-inverse_is_a: HGNC:TNNI3
+relationship: part_of FPLX:000477 ! Troponin
+relationship: inverse_is_a HGNC:11945 ! TNNI1
+relationship: inverse_is_a HGNC:11946 ! TNNI2
+relationship: inverse_is_a HGNC:11947 ! TNNI3
 
 [Term]
-id: FPLX:Troponin_T
+id: FPLX:000480
 name: Troponin-T
 synonym: "cTnT" EXACT []
 synonym: "TPNT" EXACT []
@@ -8001,13 +8021,13 @@ synonym: "troponin T" EXACT []
 xref: IP:IPR027707
 xref: NCIT:C38041
 xref: RE:R-HSA-390546
-part_of: FPLX:Troponin
-inverse_is_a: HGNC:TNNT1
-inverse_is_a: HGNC:TNNT2
-inverse_is_a: HGNC:TNNT3
+relationship: part_of FPLX:000477 ! Troponin
+relationship: inverse_is_a HGNC:11948 ! TNNT1
+relationship: inverse_is_a HGNC:11949 ! TNNT2
+relationship: inverse_is_a HGNC:11950 ! TNNT3
 
 [Term]
-id: FPLX:Tryptase
+id: FPLX:000481
 name: Tryptase
 synonym: "Tryptase" EXACT []
 synonym: "tryptase" EXACT []
@@ -8016,26 +8036,26 @@ xref: BEL:"Tryptase Family"
 xref: ECCODE:3.4.21.59
 xref: NCIT:C120030
 xref: NEXTPROT-FAMILY:02767
-is_a: FPLX:root
-inverse_is_a: HGNC:TPSAB1
-inverse_is_a: HGNC:TPSB2
-inverse_is_a: HGNC:TPSD1
-inverse_is_a: HGNC:TPSG1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12019 ! TPSAB1
+relationship: inverse_is_a HGNC:14120 ! TPSB2
+relationship: inverse_is_a HGNC:14118 ! TPSD1
+relationship: inverse_is_a HGNC:14134 ! TPSG1
 
 [Term]
-id: FPLX:TSC
+id: FPLX:000482
 name: TSC
 synonym: "TSC" EXACT []
 xref: RE:R-HSA-165175
 xref: RE:R-HSA-165180
 xref: RE:R-HSA-381855
 xref: RE:R-HSA-5672337
-is_a: FPLX:root
-inverse_is_a: HGNC:TSC1
-inverse_is_a: HGNC:TSC2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12362 ! TSC1
+relationship: inverse_is_a HGNC:12363 ! TSC2
 
 [Term]
-id: FPLX:TUBA
+id: FPLX:000483
 name: TUBA
 synonym: "alpha tubulin" EXACT []
 synonym: "TUBA" EXACT []
@@ -8043,19 +8063,19 @@ synonym: "tubulin alpha chain" EXACT []
 synonym: "tubulin α chain" EXACT []
 synonym: "α tubulin" EXACT []
 xref: BEL:"TUBA Family"
-is_a: FPLX:Tubulin
-inverse_is_a: HGNC:TUBA1A
-inverse_is_a: HGNC:TUBA1B
-inverse_is_a: HGNC:TUBA1C
-inverse_is_a: HGNC:TUBA3C
-inverse_is_a: HGNC:TUBA3D
-inverse_is_a: HGNC:TUBA3E
-inverse_is_a: HGNC:TUBA4A
-inverse_is_a: HGNC:TUBA8
-inverse_is_a: HGNC:TUBAL3
-
-[Term]
-id: FPLX:TUBB
+is_a: FPLX:000486 ! Tubulin
+relationship: inverse_is_a HGNC:20766 ! TUBA1A
+relationship: inverse_is_a HGNC:18809 ! TUBA1B
+relationship: inverse_is_a HGNC:20768 ! TUBA1C
+relationship: inverse_is_a HGNC:12408 ! TUBA3C
+relationship: inverse_is_a HGNC:24071 ! TUBA3D
+relationship: inverse_is_a HGNC:20765 ! TUBA3E
+relationship: inverse_is_a HGNC:12407 ! TUBA4A
+relationship: inverse_is_a HGNC:12410 ! TUBA8
+relationship: inverse_is_a HGNC:23534 ! TUBAL3
+
+[Term]
+id: FPLX:000484
 name: TUBB
 synonym: "Beta Tubulin" EXACT []
 synonym: "Beta tubulin" EXACT []
@@ -8073,18 +8093,18 @@ synonym: "tubulin β" EXACT []
 xref: BEL:"TUBB Family"
 xref: IP:IPR002453
 xref: NCIT:C129655
-is_a: FPLX:Tubulin
-inverse_is_a: HGNC:TUBB
-inverse_is_a: HGNC:TUBB1
-inverse_is_a: HGNC:TUBB2A
-inverse_is_a: HGNC:TUBB2B
-inverse_is_a: HGNC:TUBB3
-inverse_is_a: HGNC:TUBB4A
-inverse_is_a: HGNC:TUBB4B
-inverse_is_a: HGNC:TUBB6
-
-[Term]
-id: FPLX:TUBG
+is_a: FPLX:000486 ! Tubulin
+relationship: inverse_is_a HGNC:20778 ! TUBB
+relationship: inverse_is_a HGNC:16257 ! TUBB1
+relationship: inverse_is_a HGNC:12412 ! TUBB2A
+relationship: inverse_is_a HGNC:30829 ! TUBB2B
+relationship: inverse_is_a HGNC:20772 ! TUBB3
+relationship: inverse_is_a HGNC:20774 ! TUBB4A
+relationship: inverse_is_a HGNC:20771 ! TUBB4B
+relationship: inverse_is_a HGNC:20776 ! TUBB6
+
+[Term]
+id: FPLX:000485
 name: TUBG
 synonym: "Gamma tubulin" EXACT []
 synonym: "gamma tubulin" EXACT []
@@ -8095,27 +8115,27 @@ synonym: "γ tubulin" EXACT []
 synonym: "γ-tubulin" EXACT []
 xref: GO:0000930
 xref: IP:IPR002454
-is_a: FPLX:Tubulin
-inverse_is_a: HGNC:TUBG1
-inverse_is_a: HGNC:TUBG2
+is_a: FPLX:000486 ! Tubulin
+relationship: inverse_is_a HGNC:12417 ! TUBG1
+relationship: inverse_is_a HGNC:12419 ! TUBG2
 
 [Term]
-id: FPLX:Tubulin
+id: FPLX:000486
 name: Tubulin
 synonym: "tubulin" EXACT []
 xref: MEDSCAN:urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802
 xref: MEDSCAN:urn:agi-protfc:tubulin
 xref: NCIT:C17219
 xref: NEXTPROT-FAMILY:04239
-is_a: FPLX:root
-inverse_is_a: FPLX:TUBA
-inverse_is_a: FPLX:TUBB
-inverse_is_a: FPLX:TUBG
-inverse_is_a: HGNC:TUBD1
-inverse_is_a: HGNC:TUBE1
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000483 ! TUBA
+relationship: inverse_is_a FPLX:000484 ! TUBB
+relationship: inverse_is_a FPLX:000485 ! TUBG
+relationship: inverse_is_a HGNC:16811 ! TUBD1
+relationship: inverse_is_a HGNC:20775 ! TUBE1
 
 [Term]
-id: FPLX:TXN
+id: FPLX:000487
 name: TXN
 synonym: "Thioredoxin" EXACT []
 synonym: "thioredoxin" EXACT []
@@ -8123,24 +8143,24 @@ synonym: "thioredoxins" EXACT []
 xref: BEL:"TXN Family"
 xref: MEDSCAN:urn:agi-protfc:thioredoxin
 xref: NEXTPROT-FAMILY:04000
-is_a: FPLX:root
-inverse_is_a: HGNC:TXN
-inverse_is_a: HGNC:TXN2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12435 ! TXN
+relationship: inverse_is_a HGNC:17772 ! TXN2
 
 [Term]
-id: FPLX:TXNRD
+id: FPLX:000488
 name: TXNRD
 synonym: "Thioredoxin reductase" EXACT []
 synonym: "thioredoxin reductase" EXACT []
 xref: BEL:"TXNRD Family"
 xref: IP:IPR006338
-is_a: FPLX:root
-inverse_is_a: HGNC:TXNRD1
-inverse_is_a: HGNC:TXNRD2
-inverse_is_a: HGNC:TXNRD3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12437 ! TXNRD1
+relationship: inverse_is_a HGNC:18155 ! TXNRD2
+relationship: inverse_is_a HGNC:20667 ! TXNRD3
 
 [Term]
-id: FPLX:UBE2
+id: FPLX:000489
 name: UBE2
 synonym: "E2 enzyme" EXACT []
 synonym: "E2 ubiquitin-conjugating enzyme" EXACT []
@@ -8152,39 +8172,39 @@ xref: BEL:"UBE2 Family"
 xref: ECCODE:2.3.2.23
 xref: GO:0019787
 xref: NEXTPROT-FAMILY:04282
-is_a: FPLX:root
-inverse_is_a: HGNC:CDC34
-inverse_is_a: HGNC:UBE2A
-inverse_is_a: HGNC:UBE2B
-inverse_is_a: HGNC:UBE2C
-inverse_is_a: HGNC:UBE2D1
-inverse_is_a: HGNC:UBE2D2
-inverse_is_a: HGNC:UBE2D3
-inverse_is_a: HGNC:UBE2D4
-inverse_is_a: HGNC:UBE2E1
-inverse_is_a: HGNC:UBE2E2
-inverse_is_a: HGNC:UBE2E3
-inverse_is_a: HGNC:UBE2F
-inverse_is_a: HGNC:UBE2G1
-inverse_is_a: HGNC:UBE2G2
-inverse_is_a: HGNC:UBE2H
-inverse_is_a: HGNC:UBE2I
-inverse_is_a: HGNC:UBE2J1
-inverse_is_a: HGNC:UBE2J2
-inverse_is_a: HGNC:UBE2L3
-inverse_is_a: HGNC:UBE2L6
-inverse_is_a: HGNC:UBE2M
-inverse_is_a: HGNC:UBE2N
-inverse_is_a: HGNC:UBE2NL
-inverse_is_a: HGNC:UBE2Q1
-inverse_is_a: HGNC:UBE2R2
-inverse_is_a: HGNC:UBE2S
-inverse_is_a: HGNC:UBE2V1
-inverse_is_a: HGNC:UBE2V2
-inverse_is_a: HGNC:UBE2W
-
-[Term]
-id: FPLX:Ubiquitin
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1734 ! CDC34
+relationship: inverse_is_a HGNC:12472 ! UBE2A
+relationship: inverse_is_a HGNC:12473 ! UBE2B
+relationship: inverse_is_a HGNC:15937 ! UBE2C
+relationship: inverse_is_a HGNC:12474 ! UBE2D1
+relationship: inverse_is_a HGNC:12475 ! UBE2D2
+relationship: inverse_is_a HGNC:12476 ! UBE2D3
+relationship: inverse_is_a HGNC:21647 ! UBE2D4
+relationship: inverse_is_a HGNC:12477 ! UBE2E1
+relationship: inverse_is_a HGNC:12478 ! UBE2E2
+relationship: inverse_is_a HGNC:12479 ! UBE2E3
+relationship: inverse_is_a HGNC:12480 ! UBE2F
+relationship: inverse_is_a HGNC:12482 ! UBE2G1
+relationship: inverse_is_a HGNC:12483 ! UBE2G2
+relationship: inverse_is_a HGNC:12484 ! UBE2H
+relationship: inverse_is_a HGNC:12485 ! UBE2I
+relationship: inverse_is_a HGNC:17598 ! UBE2J1
+relationship: inverse_is_a HGNC:19268 ! UBE2J2
+relationship: inverse_is_a HGNC:12488 ! UBE2L3
+relationship: inverse_is_a HGNC:12490 ! UBE2L6
+relationship: inverse_is_a HGNC:12491 ! UBE2M
+relationship: inverse_is_a HGNC:12492 ! UBE2N
+relationship: inverse_is_a HGNC:31710 ! UBE2NL
+relationship: inverse_is_a HGNC:15698 ! UBE2Q1
+relationship: inverse_is_a HGNC:19907 ! UBE2R2
+relationship: inverse_is_a HGNC:17895 ! UBE2S
+relationship: inverse_is_a HGNC:12494 ! UBE2V1
+relationship: inverse_is_a HGNC:12495 ! UBE2V2
+relationship: inverse_is_a HGNC:25616 ! UBE2W
+
+[Term]
+id: FPLX:000490
 name: Ubiquitin
 synonym: "Ub" EXACT []
 synonym: "ub" EXACT []
@@ -8194,61 +8214,61 @@ xref: MEDSCAN:urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd
 xref: MEDSCAN:urn:agi-protfc:ubiquitin
 xref: NCIT:C17227
 xref: NEXTPROT-FAMILY:04276
-is_a: FPLX:root
+is_a: FPLX:000000 ! famplex
 
 [Term]
-id: FPLX:UGCG
+id: FPLX:000491
 name: UGCG
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:UGCG
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:12524 ! UGCG
 
 [Term]
-id: FPLX:UGT
+id: FPLX:000492
 name: UGT
 synonym: "UGT" EXACT []
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:UGT1A
-inverse_is_a: HGNC:UGT1A1
-inverse_is_a: HGNC:UGT1A2P
-inverse_is_a: HGNC:UGT1A3
-inverse_is_a: HGNC:UGT1A4
-inverse_is_a: HGNC:UGT1A5
-inverse_is_a: HGNC:UGT1A6
-inverse_is_a: HGNC:UGT1A7
-inverse_is_a: HGNC:UGT1A8
-inverse_is_a: HGNC:UGT1A9
-inverse_is_a: HGNC:UGT1A10
-inverse_is_a: HGNC:UGT1A11P
-inverse_is_a: HGNC:UGT1A12P
-inverse_is_a: HGNC:UGT1A13P
-inverse_is_a: HGNC:UGT2A1
-inverse_is_a: HGNC:UGT2A2
-inverse_is_a: HGNC:UGT2A3
-inverse_is_a: HGNC:UGT2B4
-inverse_is_a: HGNC:UGT2B7
-inverse_is_a: HGNC:UGT2B10
-inverse_is_a: HGNC:UGT2B11
-inverse_is_a: HGNC:UGT2B15
-inverse_is_a: HGNC:UGT2B17
-inverse_is_a: HGNC:UGT2B24P
-inverse_is_a: HGNC:UGT2B25P
-inverse_is_a: HGNC:UGT2B26P
-inverse_is_a: HGNC:UGT2B27P
-inverse_is_a: HGNC:UGT2B28
-inverse_is_a: HGNC:UGT2B29P
-inverse_is_a: HGNC:UGT3A1
-inverse_is_a: HGNC:UGT3A2
-inverse_is_a: HGNC:UGT8
-
-[Term]
-id: FPLX:UGGT
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:12529 ! UGT1A
+relationship: inverse_is_a HGNC:12530 ! UGT1A1
+relationship: inverse_is_a HGNC:12534 ! UGT1A2P
+relationship: inverse_is_a HGNC:12535 ! UGT1A3
+relationship: inverse_is_a HGNC:12536 ! UGT1A4
+relationship: inverse_is_a HGNC:12537 ! UGT1A5
+relationship: inverse_is_a HGNC:12538 ! UGT1A6
+relationship: inverse_is_a HGNC:12539 ! UGT1A7
+relationship: inverse_is_a HGNC:12540 ! UGT1A8
+relationship: inverse_is_a HGNC:12541 ! UGT1A9
+relationship: inverse_is_a HGNC:12531 ! UGT1A10
+relationship: inverse_is_a HGNC:12532 ! UGT1A11P
+relationship: inverse_is_a HGNC:12533 ! UGT1A12P
+relationship: inverse_is_a HGNC:32191 ! UGT1A13P
+relationship: inverse_is_a HGNC:12542 ! UGT2A1
+relationship: inverse_is_a HGNC:28183 ! UGT2A2
+relationship: inverse_is_a HGNC:28528 ! UGT2A3
+relationship: inverse_is_a HGNC:12553 ! UGT2B4
+relationship: inverse_is_a HGNC:12554 ! UGT2B7
+relationship: inverse_is_a HGNC:12544 ! UGT2B10
+relationship: inverse_is_a HGNC:12545 ! UGT2B11
+relationship: inverse_is_a HGNC:12546 ! UGT2B15
+relationship: inverse_is_a HGNC:12547 ! UGT2B17
+relationship: inverse_is_a HGNC:12548 ! UGT2B24P
+relationship: inverse_is_a HGNC:12549 ! UGT2B25P
+relationship: inverse_is_a HGNC:12550 ! UGT2B26P
+relationship: inverse_is_a HGNC:12551 ! UGT2B27P
+relationship: inverse_is_a HGNC:13479 ! UGT2B28
+relationship: inverse_is_a HGNC:12552 ! UGT2B29P
+relationship: inverse_is_a HGNC:26625 ! UGT3A1
+relationship: inverse_is_a HGNC:27266 ! UGT3A2
+relationship: inverse_is_a HGNC:12555 ! UGT8
+
+[Term]
+id: FPLX:000493
 name: UGGT
-is_a: FPLX:Glycosyltransferase
-inverse_is_a: HGNC:UGGT1
-inverse_is_a: HGNC:UGGT2
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:15663 ! UGGT1
+relationship: inverse_is_a HGNC:15664 ! UGGT2
 
 [Term]
-id: FPLX:VAV
+id: FPLX:000494
 name: VAV
 synonym: "VAV family" EXACT []
 synonym: "Vav" EXACT []
@@ -8261,13 +8281,13 @@ xref: RE:R-HSA-442272
 xref: RE:R-HSA-442295
 xref: RE:R-HSA-5218789
 xref: RE:R-HSA-5340329
-is_a: FPLX:root
-inverse_is_a: HGNC:VAV1
-inverse_is_a: HGNC:VAV2
-inverse_is_a: HGNC:VAV3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12657 ! VAV1
+relationship: inverse_is_a HGNC:12658 ! VAV2
+relationship: inverse_is_a HGNC:12659 ! VAV3
 
 [Term]
-id: FPLX:VEGF
+id: FPLX:000495
 name: VEGF
 synonym: "vascular endothelial growth factor" EXACT []
 synonym: "VEGF" EXACT []
@@ -8275,15 +8295,15 @@ xref: BEL:"VEGF Family"
 xref: NCIT:C129646
 xref: RE:R-HSA-195361
 xref: RE:R-HSA-195376
-is_a: FPLX:root
-inverse_is_a: HGNC:VEGFA
-inverse_is_a: HGNC:VEGFB
-inverse_is_a: HGNC:VEGFC
-inverse_is_a: HGNC:VEGFD
-inverse_is_a: HGNC:PGF
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12680 ! VEGFA
+relationship: inverse_is_a HGNC:12681 ! VEGFB
+relationship: inverse_is_a HGNC:12682 ! VEGFC
+relationship: inverse_is_a HGNC:3708 ! VEGFD
+relationship: inverse_is_a HGNC:8893 ! PGF
 
 [Term]
-id: FPLX:VEGFR
+id: FPLX:000496
 name: VEGFR
 synonym: "VEGF receptor" EXACT []
 synonym: "VEGF receptors" EXACT []
@@ -8293,13 +8313,13 @@ synonym: "VEGFRs" EXACT []
 xref: BEL:"VEGFR Family"
 xref: GO:0005172
 xref: NCIT:C17293
-is_a: FPLX:root
-inverse_is_a: HGNC:FLT1
-inverse_is_a: HGNC:FLT4
-inverse_is_a: HGNC:KDR
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3763 ! FLT1
+relationship: inverse_is_a HGNC:3767 ! FLT4
+relationship: inverse_is_a HGNC:6307 ! KDR
 
 [Term]
-id: FPLX:Wnt
+id: FPLX:000497
 name: Wnt
 synonym: "WNT" EXACT []
 synonym: "Wnt" EXACT []
@@ -8314,96 +8334,96 @@ xref: RE:R-HSA-3238374
 xref: RE:R-HSA-3247790
 xref: RE:R-HSA-3247824
 xref: RE:R-HSA-3247835
-is_a: FPLX:root
-inverse_is_a: HGNC:WNT1
-inverse_is_a: HGNC:WNT2
-inverse_is_a: HGNC:WNT2B
-inverse_is_a: HGNC:WNT3
-inverse_is_a: HGNC:WNT3A
-inverse_is_a: HGNC:WNT4
-inverse_is_a: HGNC:WNT5A
-inverse_is_a: HGNC:WNT5B
-inverse_is_a: HGNC:WNT6
-inverse_is_a: HGNC:WNT7A
-inverse_is_a: HGNC:WNT7B
-inverse_is_a: HGNC:WNT8A
-inverse_is_a: HGNC:WNT8B
-inverse_is_a: HGNC:WNT9A
-inverse_is_a: HGNC:WNT9B
-inverse_is_a: HGNC:WNT10A
-inverse_is_a: HGNC:WNT10B
-inverse_is_a: HGNC:WNT11
-inverse_is_a: HGNC:WNT16
-
-[Term]
-id: FPLX:YBX
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12774 ! WNT1
+relationship: inverse_is_a HGNC:12780 ! WNT2
+relationship: inverse_is_a HGNC:12781 ! WNT2B
+relationship: inverse_is_a HGNC:12782 ! WNT3
+relationship: inverse_is_a HGNC:15983 ! WNT3A
+relationship: inverse_is_a HGNC:12783 ! WNT4
+relationship: inverse_is_a HGNC:12784 ! WNT5A
+relationship: inverse_is_a HGNC:16265 ! WNT5B
+relationship: inverse_is_a HGNC:12785 ! WNT6
+relationship: inverse_is_a HGNC:12786 ! WNT7A
+relationship: inverse_is_a HGNC:12787 ! WNT7B
+relationship: inverse_is_a HGNC:12788 ! WNT8A
+relationship: inverse_is_a HGNC:12789 ! WNT8B
+relationship: inverse_is_a HGNC:12778 ! WNT9A
+relationship: inverse_is_a HGNC:12779 ! WNT9B
+relationship: inverse_is_a HGNC:13829 ! WNT10A
+relationship: inverse_is_a HGNC:12775 ! WNT10B
+relationship: inverse_is_a HGNC:12776 ! WNT11
+relationship: inverse_is_a HGNC:16267 ! WNT16
+
+[Term]
+id: FPLX:000498
 name: YBX
 synonym: "Y box binding protein" EXACT []
 synonym: "Y-box-binding protein" EXACT []
 synonym: "YBX protein family" EXACT []
-is_a: FPLX:root
-inverse_is_a: HGNC:YBX1
-inverse_is_a: HGNC:YBX2
-inverse_is_a: HGNC:YBX3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8014 ! YBX1
+relationship: inverse_is_a HGNC:17948 ! YBX2
+relationship: inverse_is_a HGNC:2428 ! YBX3
 
 [Term]
-id: FPLX:ETC_complex_I_core
+id: FPLX:000499
 name: ETC-complex-I-core
 xref: HGNC_GROUP:1149
-part_of: FPLX:ETC_complex_I
-has_part: HGNC:MT-ND1
-has_part: HGNC:MT-ND2
-has_part: HGNC:MT-ND3
-has_part: HGNC:MT-ND4
-has_part: HGNC:MT-ND4L
-has_part: HGNC:MT-ND5
-has_part: HGNC:MT-ND6
-has_part: HGNC:NDUFS1
-has_part: HGNC:NDUFS2
-has_part: HGNC:NDUFS3
-has_part: HGNC:NDUFS7
-has_part: HGNC:NDUFS8
-has_part: HGNC:NDUFV1
-has_part: HGNC:NDUFV2
-
-[Term]
-id: FPLX:ETC_complex_I_supernumerary
+relationship: part_of FPLX:000501 ! ETC_complex_I
+relationship: has_part HGNC:7455 ! MT-ND1
+relationship: has_part HGNC:7456 ! MT-ND2
+relationship: has_part HGNC:7458 ! MT-ND3
+relationship: has_part HGNC:7459 ! MT-ND4
+relationship: has_part HGNC:7460 ! MT-ND4L
+relationship: has_part HGNC:7461 ! MT-ND5
+relationship: has_part HGNC:7462 ! MT-ND6
+relationship: has_part HGNC:7707 ! NDUFS1
+relationship: has_part HGNC:7708 ! NDUFS2
+relationship: has_part HGNC:7710 ! NDUFS3
+relationship: has_part HGNC:7714 ! NDUFS7
+relationship: has_part HGNC:7715 ! NDUFS8
+relationship: has_part HGNC:7716 ! NDUFV1
+relationship: has_part HGNC:7717 ! NDUFV2
+
+[Term]
+id: FPLX:000500
 name: ETC-complex-I-supernumerary
 xref: HGNC_GROUP:1150
-part_of: FPLX:ETC_complex_I
-has_part: HGNC:NDUFAB1
-has_part: HGNC:NDUFA1
-has_part: HGNC:NDUFA2
-has_part: HGNC:NDUFA3
-has_part: HGNC:NDUFA5
-has_part: HGNC:NDUFA6
-has_part: HGNC:NDUFA7
-has_part: HGNC:NDUFA8
-has_part: HGNC:NDUFA9
-has_part: HGNC:NDUFA10
-has_part: HGNC:NDUFA11
-has_part: HGNC:NDUFA12
-has_part: HGNC:NDUFA13
-has_part: HGNC:NDUFB1
-has_part: HGNC:NDUFB2
-has_part: HGNC:NDUFB3
-has_part: HGNC:NDUFB4
-has_part: HGNC:NDUFB5
-has_part: HGNC:NDUFB6
-has_part: HGNC:NDUFB7
-has_part: HGNC:NDUFB8
-has_part: HGNC:NDUFB9
-has_part: HGNC:NDUFB10
-has_part: HGNC:NDUFB11
-has_part: HGNC:NDUFC1
-has_part: HGNC:NDUFC2
-has_part: HGNC:NDUFS4
-has_part: HGNC:NDUFS5
-has_part: HGNC:NDUFS6
-has_part: HGNC:NDUFV3
-
-[Term]
-id: FPLX:ETC_complex_I
+relationship: part_of FPLX:000501 ! ETC_complex_I
+relationship: has_part HGNC:7694 ! NDUFAB1
+relationship: has_part HGNC:7683 ! NDUFA1
+relationship: has_part HGNC:7685 ! NDUFA2
+relationship: has_part HGNC:7686 ! NDUFA3
+relationship: has_part HGNC:7688 ! NDUFA5
+relationship: has_part HGNC:7690 ! NDUFA6
+relationship: has_part HGNC:7691 ! NDUFA7
+relationship: has_part HGNC:7692 ! NDUFA8
+relationship: has_part HGNC:7693 ! NDUFA9
+relationship: has_part HGNC:7684 ! NDUFA10
+relationship: has_part HGNC:20371 ! NDUFA11
+relationship: has_part HGNC:23987 ! NDUFA12
+relationship: has_part HGNC:17194 ! NDUFA13
+relationship: has_part HGNC:7695 ! NDUFB1
+relationship: has_part HGNC:7697 ! NDUFB2
+relationship: has_part HGNC:7698 ! NDUFB3
+relationship: has_part HGNC:7699 ! NDUFB4
+relationship: has_part HGNC:7700 ! NDUFB5
+relationship: has_part HGNC:7701 ! NDUFB6
+relationship: has_part HGNC:7702 ! NDUFB7
+relationship: has_part HGNC:7703 ! NDUFB8
+relationship: has_part HGNC:7704 ! NDUFB9
+relationship: has_part HGNC:7696 ! NDUFB10
+relationship: has_part HGNC:20372 ! NDUFB11
+relationship: has_part HGNC:7705 ! NDUFC1
+relationship: has_part HGNC:7706 ! NDUFC2
+relationship: has_part HGNC:7711 ! NDUFS4
+relationship: has_part HGNC:7712 ! NDUFS5
+relationship: has_part HGNC:7713 ! NDUFS6
+relationship: has_part HGNC:7719 ! NDUFV3
+
+[Term]
+id: FPLX:000501
 name: ETC-complex-I
 xref: COMPLEXPORTAL:CPX-577
 xref: ECCODE:1.6.5.3
@@ -8411,12 +8431,12 @@ xref: GO:0005747
 xref: HGNC_GROUP:640
 xref: MESH:D042967
 xref: NCIT:C118184
-is_a: FPLX:root
-has_part: FPLX:ETC_complex_I_core
-has_part: FPLX:ETC_complex_I_supernumerary
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000499 ! ETC_complex_I_core
+relationship: has_part FPLX:000500 ! ETC_complex_I_supernumerary
 
 [Term]
-id: FPLX:ETC_complex_II
+id: FPLX:000502
 name: ETC-complex-II
 synonym: "complex II" EXACT []
 synonym: "succinate dehydrogenase (ubiquinone)" EXACT []
@@ -8430,14 +8450,14 @@ xref: MESH:D042963
 xref: NCIT:C112049
 xref: RE:R-HSA-165631
 xref: RE:R-HSA-70990
-is_a: FPLX:root
-has_part: HGNC:SDHA
-has_part: HGNC:SDHB
-has_part: HGNC:SDHC
-has_part: HGNC:SDHD
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:10680 ! SDHA
+relationship: has_part HGNC:10681 ! SDHB
+relationship: has_part HGNC:10682 ! SDHC
+relationship: has_part HGNC:10683 ! SDHD
 
 [Term]
-id: FPLX:ETC_complex_III
+id: FPLX:000503
 name: ETC-complex-III
 synonym: "complex III" EXACT []
 synonym: "cytochrome bc1 complex" EXACT []
@@ -8448,57 +8468,53 @@ xref: GO:0005750
 xref: GO:0045275
 xref: HGNC_GROUP:642
 xref: MESH:D014450
-is_a: FPLX:root
-has_part: HGNC:CYC1
-has_part: HGNC:MT-CYB
-has_part: HGNC:UQCRB
-has_part: HGNC:UQCRC1
-has_part: HGNC:UQCRC2
-has_part: HGNC:UQCRFS1
-has_part: HGNC:UQCRH
-has_part: HGNC:UQCRQ
-has_part: HGNC:UQCR10
-has_part: HGNC:UQCR11
-
-[Term]
-id: FPLX:ETC_complex_IV
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2579 ! CYC1
+relationship: has_part HGNC:7427 ! MT-CYB
+relationship: has_part HGNC:12582 ! UQCRB
+relationship: has_part HGNC:12585 ! UQCRC1
+relationship: has_part HGNC:12586 ! UQCRC2
+relationship: has_part HGNC:12587 ! UQCRFS1
+relationship: has_part HGNC:12590 ! UQCRH
+relationship: has_part HGNC:29594 ! UQCRQ
+relationship: has_part HGNC:30863 ! UQCR10
+relationship: has_part HGNC:30862 ! UQCR11
+
+[Term]
+id: FPLX:000504
 name: ETC-complex-IV
 xref: ECCODE:1.9.3.1
 xref: GO:0005751
 xref: HGNC_GROUP:643
 xref: MESH:D003576
 xref: NCIT:C26034
-is_a: FPLX:root
-has_part: HGNC:COX4I1
-has_part: HGNC:COX4I2
-has_part: HGNC:COX5A
-has_part: HGNC:COX5B
-has_part: HGNC:COX6A1
-has_part: HGNC:COX6A2
-has_part: HGNC:COX6B1
-has_part: HGNC:COX6B2
-has_part: HGNC:COX6C
-has_part: HGNC:COX7A1
-has_part: HGNC:COX7A2
-has_part: HGNC:COX7B
-has_part: HGNC:COX7B2
-has_part: HGNC:COX7C
-has_part: HGNC:COX8A
-has_part: HGNC:COX8C
-has_part: HGNC:MT-CO1
-has_part: HGNC:MT-CO2
-has_part: HGNC:MT-CO3
-
-[Term]
-id: FPLX:ETC_complex_V
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2265 ! COX4I1
+relationship: has_part HGNC:16232 ! COX4I2
+relationship: has_part HGNC:2267 ! COX5A
+relationship: has_part HGNC:2269 ! COX5B
+relationship: has_part HGNC:2277 ! COX6A1
+relationship: has_part HGNC:2279 ! COX6A2
+relationship: has_part HGNC:2280 ! COX6B1
+relationship: has_part HGNC:24380 ! COX6B2
+relationship: has_part HGNC:2285 ! COX6C
+relationship: has_part HGNC:2287 ! COX7A1
+relationship: has_part HGNC:2288 ! COX7A2
+relationship: has_part HGNC:2291 ! COX7B
+relationship: has_part HGNC:24381 ! COX7B2
+relationship: has_part HGNC:2292 ! COX7C
+relationship: has_part HGNC:2294 ! COX8A
+relationship: has_part HGNC:24382 ! COX8C
+relationship: has_part HGNC:7419 ! MT-CO1
+relationship: has_part HGNC:7421 ! MT-CO2
+relationship: has_part HGNC:7422 ! MT-CO3
+
+[Term]
+id: FPLX:000505
 name: ETC-complex-V
 xref: ECCODE:3.6.3.14
 xref: GO:0005753
 xref: HGNC_GROUP:644
 xref: MESH:D025261
-is_a: FPLX:root
-
-[Term]
-id: FPLX:root
-name: PROTEIN-FAMILY-OR-COMPLEX
+is_a: FPLX:000000 ! famplex
 
diff --git a/export/hgnc_ids.py b/export/hgnc_ids.py
deleted file mode 100644
index b5c46dd34..000000000
--- a/export/hgnc_ids.py
+++ /dev/null
@@ -1,47 +0,0 @@
-"""Several files in this resource use HGNC gene symbols to identify individual
-genes. However, the symbols assigned to HGNC IDs can change over time, and
-therefore previously curated symbols can become invalid. This script
-generates a mapping of current (i.e. at the time of running the script)
-mappings of HGNC IDs to symbols so that the assumptions about the identity
-of the genes in the various tables can be traced."""
-
-import os
-import csv
-from indra.databases import hgnc_client
-
-if __name__ == '__main__':
-    path_this = os.path.dirname(os.path.abspath(__file__))
-    hgnc_symbols = set()
-    # Gather all HGNC symbols from relations.csv
-    relations_file = os.path.join(path_this, os.pardir, 'relations.csv')
-    with open(relations_file, 'r') as f:
-        csvreader = csv.reader(f, delimiter=str(u','), lineterminator='\r\n',
-                               quoting=csv.QUOTE_MINIMAL,
-                               quotechar=str(u'"'))
-        for row in csvreader:
-            ns1, id1, rel, ns2, id2 = row
-            if ns1 == 'HGNC':
-                hgnc_symbols.add(id1)
-            if ns2 == 'HGNC':
-                hgnc_symbols.add(id2)
-
-    # Gather all HGNC symbols from grounding_map.csv
-    gm_file = os.path.join(path_this, os.pardir, 'grounding_map.csv')
-    with open(gm_file, 'r') as f:
-        csvreader = csv.reader(f, delimiter=str(u','), lineterminator='\r\n',
-                               quoting=csv.QUOTE_MINIMAL,
-                               quotechar=str(u'"'))
-        for row in csvreader:
-            namespaces = row[1::2]
-            ids = row[2::2]
-            for ns, id in zip(namespaces, ids):
-                if ns == 'HGNC':
-                    hgnc_symbols.add(id)
-
-    # Create output file
-    out_file = os.path.join(path_this, 'hgnc_symbol_map.csv')
-    with open(out_file, 'w') as fh:
-        for hgnc_symbol in sorted(list(hgnc_symbols)):
-            hgnc_id = hgnc_client.get_hgnc_id(hgnc_symbol)
-            fh.write('%s,%s\r\n' % (hgnc_symbol, hgnc_id))
-
diff --git a/export/obo.py b/export/obo.py
deleted file mode 100644
index 66f2da58e..000000000
--- a/export/obo.py
+++ /dev/null
@@ -1,153 +0,0 @@
-import os
-import csv
-import sys
-import datetime
-import collections
-
-
-if sys.version_info.major < 3:
-    raise Exception('This script should be run in Python 3.')
-
-
-Reference = collections.namedtuple('Reference', ['ns', 'id'])
-Synonym = collections.namedtuple('Synonym', ['name', 'status'])
-
-
-class OboTerm(object):
-    def __init__(self, term_id, name, rels, synonyms=None, xrefs=None):
-        self.term_id = term_id
-        self.name = name
-        self.synonyms = synonyms
-        if xrefs is not None:
-            self.xrefs = xrefs
-        else:
-            self.xrefs = []
-        self.rels = rels
-
-    def to_obo(self):
-        obo_str = '[Term]\n'
-        obo_str += 'id: %s:%s\n' % (self.term_id.ns, self.term_id.id)
-        obo_str += 'name: %s\n' % self.name
-        for synonym in self.synonyms:
-            obo_str += 'synonym: "%s" %s []\n' % (synonym.name, synonym.status)
-        for xref in self.xrefs:
-            if xref.ns == 'BEL':
-                entry = 'BEL:"%s"' % xref.id
-            elif xref.ns == 'NXP':
-                entry = 'NEXTPROT-FAMILY:%s' % xref.id[3:]
-            elif xref.ns == 'PF':
-                entry = 'XFAM:%s' % xref.id
-            elif xref.ns == 'GO':
-                entry = xref.id
-            else:
-                entry = '%s:%s' % (xref.ns, xref.id)
-            obo_str += 'xref: %s\n' % entry
-        for rel_type, rel_entries in self.rels.items():
-            for ref in rel_entries:
-                obo_str += '%s: %s:%s\n' % (rel_type, ref.ns, ref.id)
-        return obo_str
-
-    def __str__(self):
-        return self.to_obo()
-
-
-def get_obo_terms():
-    obo_terms = []
-    path_this = os.path.dirname(os.path.abspath(__file__))
-    entities_file = os.path.join(path_this, os.pardir, 'entities.csv')
-    grounding_file = os.path.join(path_this, os.pardir, 'grounding_map.csv')
-    equiv_file = os.path.join(path_this, os.pardir, 'equivalences.csv')
-    rel_file = os.path.join(path_this, os.pardir, 'relations.csv')
-    with open(entities_file, 'r') as fh:
-        entities = [l.strip() for l in fh.readlines()]
-    with open(equiv_file, 'r') as fh:
-        csvreader = csv.reader(fh, delimiter=str(u','), lineterminator='\r\n',
-                               quoting=csv.QUOTE_MINIMAL,
-                               quotechar=str(u'"'))
-        equivalences = collections.defaultdict(list)
-        for row in csvreader:
-            source_ns, source_id, fplx_id = row
-            equivalences[fplx_id].append((source_ns, source_id))
-    with open(grounding_file) as fh:
-        csvreader = csv.reader(fh, delimiter=str(u','), lineterminator='\r\n',
-                               quoting=csv.QUOTE_MINIMAL,
-                               quotechar=str(u'"'))
-        textrefs = collections.defaultdict(list)
-        for row in csvreader:
-            text_str = row[0]
-            namespaces = row[1::2]
-            ids = row[2::2]
-            for ns, id in zip(namespaces, ids):
-                if ns == 'FPLX':
-                    textrefs[id].append(text_str)
-    with open(rel_file) as fh:
-        rels = {entity: collections.OrderedDict(is_a=[],
-                                                part_of=[],
-                                                inverse_is_a=[],
-                                                has_part=[])
-                for entity in entities}
-        csvreader = csv.reader(fh, delimiter=str(u','), lineterminator='\r\n',
-                               quoting=csv.QUOTE_MINIMAL,
-                               quotechar=str(u'"'))
-        for row in csvreader:
-            ns1, id1, rel, ns2, id2 = row
-            if ns1 == 'FPLX':
-                if rel == 'isa':
-                    rels[id1]['is_a'].append(Reference(ns2, id2))
-                elif rel == 'partof':
-                    rels[id1]['part_of'].append(Reference(ns2, id2))
-            if ns2 == 'FPLX':
-                if rel == 'isa':
-                    rels[id2]['inverse_is_a'].append(Reference(ns1, id1))
-                elif rel == 'partof':
-                    rels[id2]['has_part'].append(Reference(ns1, id1))
-
-    # For each entity in famplex
-    for entity in entities:
-        entity_id = Reference('FPLX', entity)
-        # Construct string name
-        name = entity.replace('_', '-')
-        # Get synonyms
-        refs = textrefs.get(entity)
-        synonyms = []
-        if refs:
-            for textref in refs:
-                synonyms.append(Synonym(textref, 'EXACT'))
-        # Get xrefs
-        equivs = equivalences.get(entity)
-        xrefs = []
-        if equivs:
-            for equiv in equivs:
-                xrefs.append(Reference(equiv[0], equiv[1]))
-        # If the entity has no isa relations, connect it to the root
-        if not rels[entity]['is_a'] and not rels[entity]['part_of']:
-            rels[entity]['is_a'].append(Reference('FPLX', 'root'))
-        term = OboTerm(entity_id, name, rels[entity], synonyms, xrefs)
-        obo_terms.append(term)
-    obo_terms.append(OboTerm(Reference('FPLX', 'root'),
-                             'PROTEIN-FAMILY-OR-COMPLEX',
-                             {}, [], {}))
-    return obo_terms
-
-
-def save_obo_terms(obo_terms, output_file=None):
-    date = datetime.datetime.today()
-    date_str = date.strftime('%d:%m:%Y %H:%M')
-    path_this = os.path.dirname(os.path.abspath(__file__))
-    if not output_file:
-        output_file = os.path.join(path_this, os.pardir, 'famplex.obo')
-    with open(output_file, 'wt') as fh:
-        fh.write('format-version: 1.2\n')
-        fh.write('date: %s\n' % date_str)
-        fh.write('\n')
-        for term in obo_terms:
-            obo_str = term.to_obo()
-            fh.write(obo_str)
-            fh.write('\n')
-
-
-if __name__ == '__main__':
-    obo_terms = get_obo_terms()
-    path_this = os.path.dirname(os.path.abspath(__file__))
-    save_obo_terms(obo_terms, os.path.join(path_this, 'famplex.obo'))
-
diff --git a/export/relations_graph.pdf b/export/relations_graph.pdf
new file mode 100644
index 000000000..ba6c4e66b
Binary files /dev/null and b/export/relations_graph.pdf differ
diff --git a/export/relations_graph.py b/export/relations_graph.py
deleted file mode 100644
index 2c3797322..000000000
--- a/export/relations_graph.py
+++ /dev/null
@@ -1,43 +0,0 @@
-from __future__ import print_function, unicode_literals
-import os
-import csv
-import pygraphviz as pgv
-
-
-if __name__ == '__main__':
-    path_this = os.path.dirname(os.path.abspath(__file__))
-    relations_file = os.path.join(path_this, os.pardir, 'relations.csv')
-    output_file = os.path.join(path_this, os.pardir, 'relations.pdf')
-    rows = []
-
-    graph = pgv.AGraph(name='relations', directed=True, rankdir='LR')
-    hgnc_style = {'color': 'lightgray', 'style': 'filled',
-                   'fontname': 'arial'}
-    be_style = {'color': 'pink', 'style': 'filled',
-                   'fontname': 'arial'}
-    edge_style = {'fontname': 'arial'}
-
-    with open(relations_file) as f:
-        csvreader = csv.reader(f, delimiter=str(u','), lineterminator='\r\n',
-                               quoting=csv.QUOTE_MINIMAL,
-                               quotechar=str(u'"'))
-        nodes = set([])
-        isa_edges = set([])
-        partof_edges = set([])
-        for row in csvreader:
-            ns1, id1, rel, ns2, id2 = row
-            def node_label(ns, id):
-                return '%s:%s' % (ns, id)
-            for ns, id in ((ns1, id1), (ns2, id2)):
-                if ns == 'HGNC':
-                    graph.add_node(node_label(ns, id), **hgnc_style)
-                elif ns == 'FPLX':
-                    graph.add_node(node_label(ns, id), **be_style)
-            edge = (node_label(ns1, id1), node_label(ns2, id2))
-            if rel == 'isa':
-                graph.add_edge(edge, label='isa', **edge_style)
-            elif rel == 'partof':
-                graph.add_edge(edge, label='partof', **edge_style)
-
-    graph.draw(output_file, prog='dot')
-
diff --git a/famplex/__init__.py b/famplex/__init__.py
new file mode 100644
index 000000000..aae4d554e
--- /dev/null
+++ b/famplex/__init__.py
@@ -0,0 +1,3 @@
+# -*- coding: utf-8 -*-
+
+"""FamPlex Python package."""
diff --git a/famplex/check_references.py b/famplex/check_references.py
new file mode 100644
index 000000000..e8b95947a
--- /dev/null
+++ b/famplex/check_references.py
@@ -0,0 +1,311 @@
+# -*- coding: utf-8 -*-
+
+"""Check the validity and integrity of the FamPlex resources."""
+
+import csv
+import sys
+from collections import Counter, defaultdict
+
+from famplex.constants import ENTITIES_PATH, EQUIVALENCES_PATH, GROUNDING_MAP_PATH, RELATIONS_PATH
+
+
+def load_csv(path):
+    """Load the rows of a TSV file."""
+    with open(path) as fh:
+        reader = csv.reader(
+            fh,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        return tuple(tuple(row) for row in reader)
+
+
+def load_grounding_map(filename):
+    gm_rows = load_csv(filename)
+    check_rows(gm_rows, 4, filename)
+    g_map = defaultdict(dict)
+    e_map = defaultdict(list)
+    for text, db, db_id, db_name in gm_rows:
+        g_map[text][db] = db_id
+        e_map[text, db].append((db_id, db_name))
+    return g_map, gm_rows, e_map
+
+
+def check_file_rows(filename, row_length):
+    rows = load_csv(filename)
+    check_rows(rows, row_length, filename)
+
+
+def check_rows(rows, row_length, filename):
+    for ix, row in enumerate(rows, start=1):
+        if len(row) != row_length:
+            print("ERROR: Line %d in file %s has %d columns, should be %d" %
+                  (ix, filename, len(row), row_length))
+
+
+def load_entity_list(filename):
+    rows = load_csv(filename)
+    check_rows(rows, 4, filename)
+    return rows
+
+
+def load_relationships(filename):
+    rows = load_csv(filename)
+    check_rows(rows, 7, filename)
+    return [
+        ((sns, sid, sname), rel, (ons, oid, oname))
+        for sns, sid, sname, rel, ons, oid, oname in rows
+    ]
+
+
+def load_equivalences(filename):
+    rows = load_csv(filename)
+    check_rows(rows, 4, filename)
+    return rows
+
+
+def update_id_prefixes(filename):
+    gm_rows = load_csv(filename)
+    updated_rows = []
+    for row in gm_rows:
+        key = row[0]
+        keys = [entry for entry in row[1::2]]
+        values = [entry for entry in row[2::2]]
+        if 'GO' in keys:
+            go_ix = keys.index('GO')
+            values[go_ix] = 'GO:%s' % values[go_ix]
+        if 'CHEBI' in keys:
+            chebi_ix = keys.index('CHEBI')
+            values[chebi_ix] = 'CHEBI:%s' % values[chebi_ix]
+        if 'CHEMBL' in keys:
+            chembl_ix = keys.index('CHEMBL')
+            values[chembl_ix] = 'CHEMBL%s' % values[chembl_ix]
+        updated_row = [key]
+        for pair in zip(keys, values):
+            updated_row += pair
+        updated_rows.append(updated_row)
+    return updated_rows
+
+
+def pubchem_and_chebi(db_refs):
+    pubchem_id = db_refs.get('PUBCHEM')
+    chebi_id = db_refs.get('CHEBI')
+    if pubchem_id and not chebi_id:
+        return 'chebi_missing'
+    if chebi_id and not pubchem_id:
+        return 'pubchem_missing'
+    return None
+
+
+def check_duplicates(entries, entry_label):
+    ent_counter = Counter(entries)
+    print("-- Checking for duplicate %s --" % entry_label)
+    found_duplicates = False
+    for ent, freq in ent_counter.items():
+        if freq > 1:
+            print("ERROR: Duplicate %s in %s." % (str(ent), entry_label))
+            found_duplicates = True
+    print()
+    return found_duplicates
+
+
+def main():
+    signal_error = False
+    entities = load_entity_list(ENTITIES_PATH)
+    relationships = load_relationships(RELATIONS_PATH)
+    equivalences = load_equivalences(EQUIVALENCES_PATH)
+    gm, gm_tuples, entity_to_texts = load_grounding_map(GROUNDING_MAP_PATH)
+
+    famplex_id_to_name = {
+        fplx_id: fplx_name
+        for fplx_id, fplx_name, *_ in entities
+    }
+
+    for entries, entry_label in ((entities, 'entities'),
+                                 (relationships, 'relationships'),
+                                 (equivalences, 'equivalences'),
+                                 (gm_tuples, 'groundings')):
+        if check_duplicates(entries, entry_label):
+            signal_error = True
+
+    print("-- Checking for doubly grounded text in grounding map --")
+    for (text, db), db_ids in entity_to_texts.items():
+        if len(db_ids) > 1:
+            db_ids = [
+                f'{db}:{db_id} ! {db_name}'
+                for db_id, db_name in db_ids
+            ]
+            print(f'WARNING "{text}" has multiple {db} groundings: {", ".join(db_ids)}')
+
+    print("\n-- Checking for undeclared FamPlex IDs in grounding map --")
+    # Look through grounding map and find all instances with an FPLX db key
+    entities_missing_gm = []
+    for text, db_refs in gm.items():
+        for db_key, db_id in db_refs.items():
+            if db_key == 'FPLX' and db_id not in famplex_id_to_name:
+                entities_missing_gm.append(db_id)
+                print("ERROR: ID %s referenced in grounding map "
+                      "is not in entities list." % db_id)
+                signal_error = True
+
+    print("\n-- Checking for CHEBI/PUBCHEM IDs--")
+    chebi_id_missing = []
+    pubchem_id_missing = []
+    for text, db_refs in gm.items():
+        if db_refs is not None:
+            p_and_c = pubchem_and_chebi(db_refs)
+            if p_and_c == 'chebi_missing':
+                chebi_id_missing.append(db_refs['PUBCHEM'])
+                print("WARNING: %s has PubChem ID (%s) but no CHEBI ID."
+                      % (text, db_refs['PUBCHEM']))
+            if p_and_c == 'pubchem_missing':
+                pubchem_id_missing.append(db_refs['CHEBI'])
+                print("WARNING: %s has ChEBI ID (%s) but no PUBCHEM ID." %
+                      (text, db_refs['CHEBI']))
+
+    print("\n-- Checking for undeclared FamPlex IDs in relationships file --")
+    # Load the relationships
+    # Check the relationships for consistency with entities
+    entities_missing_rel = []
+    for subj, rel, obj in relationships:
+        for term_ns, term_id, term_name in (subj, obj):
+            if term_ns == 'FPLX' and term_id not in famplex_id_to_name:
+                entities_missing_rel.append(term_id)
+                print("ERROR: ID %s referenced in relations "
+                      "is not in entities list." % term_id)
+                signal_error = True
+
+    print("\n-- Checking for valid namespaces in relations --")
+    for ix, (subj, rel, obj) in enumerate(relationships, start=1):
+        for term_ns, term_id, term_name in (subj, obj):
+            if term_ns not in ('FPLX', 'HGNC', 'UP'):
+                print("ERROR: row %d: Invalid namespace in relations.csv: %s" %
+                      (ix, term_ns))
+                signal_error = True
+
+    # This check requires the indra package
+    try:
+        from indra.databases import hgnc_client
+    except ImportError as e:
+        print('\nHGNC check could not be performed because of import error')
+        print(e)
+        signal_error = True
+    else:
+        print("\n-- Checking for invalid HGNC IDs in relationships file --")
+        for subj, rel, obj in relationships:
+            for term_ns, term_id, term_name in (subj, obj):
+                if term_ns == 'HGNC':
+                    lu_term_name = hgnc_client.get_hgnc_name(term_id)
+                    if not lu_term_name:
+                        print("ERROR: ID %s referenced in relations is "
+                              "not a valid HGNC ID." % term_id)
+                        signal_error = True
+                    if term_name != lu_term_name:
+                        print("ERROR: HGNC %s symbol out of sync."
+                              "%s should be %s" % term_id, term_name, lu_term_name)
+                        signal_error = True
+
+    # This check requires the indra package
+    try:
+        from indra.databases import hgnc_client
+    except ImportError as e:
+        print('\nHGNC check could not be performed because of import error')
+        print(e)
+        signal_error = True
+    else:
+        print("\n-- Checking for invalid HGNC IDs in grounding map --")
+        for text, db_refs in gm.items():
+            if db_refs is not None:
+                for db_key, db_id in db_refs.items():
+                    if db_key == 'HGNC':
+                        lu_term_name = hgnc_client.get_hgnc_name(db_id)
+                        if not lu_term_name:
+                            print("ERROR: ID %s in grounding map is "
+                                  "not a valid HGNC ID." % db_id)
+                            signal_error = True
+
+    # This check requires a ChEBI resource file to be available. You
+    # can obtain it from here: ftp://ftp.ebi.ac.uk/pub/databases/
+    #                          chebi/Flat_file_tab_delimited/compounds.tsv.gz
+    try:
+        with open('chebi_compounds.tsv', 'rt') as fh:
+            chebi_ids = [lin.split('\t')[2] for lin in fh.readlines()]
+    except IOError:
+        print('\n ChEBI ID check could not be performed because of IO error')
+        print(e)
+    else:
+        print("\n-- Checking for invalid ChEBI IDs in grounding map --")
+        for text, db_refs in gm.items():
+            if db_refs is None:
+                continue
+            for db_key, db_id in db_refs.items():
+                if db_key != 'CHEBI':
+                    continue
+                if db_id not in chebi_ids:
+                    print("ERROR: ID %s in grounding map is "
+                          "not a valid CHEBI ID." % db_id)
+
+    print("\n-- Checking for FamPlexes whose relationships are undefined  --")
+    # Check the relationships for consistency with entities
+    for ent in famplex_id_to_name:
+        found = any(
+            (s_ns == 'FPLX' and s_id == ent or o_ns == 'FPLX' and o_id == ent)
+            for (s_ns, s_id, _), rel, (o_ns, o_id, _) in relationships
+        )
+        if not found:
+            print("WARNING: ID %s has no known relations." % ent)
+
+    print("\n-- Checking for non-existent FamPlexes in equivalences  --")
+    entities_missing_eq = []
+    for eq_ns, eq_id, fplx_id, _ in equivalences:
+        if fplx_id not in famplex_id_to_name:
+            signal_error = True
+            entities_missing_eq.append(fplx_id)
+            print("ERROR: ID %s referenced in equivalences "
+                  "is not in entities list." % fplx_id)
+
+    print("\n-- Checking for duplicate equivalences --")
+    equiv_counter = Counter(equivalences)
+    duplicate_eq = [
+        item
+        for item, count in equiv_counter.items()
+        if count > 1
+    ]
+    if duplicate_eq:
+        print("ERROR: Duplicate equivalences found:")
+        for dup in duplicate_eq:
+            print(dup)
+
+    # This check requires the requests package to be installed
+    try:
+        import requests
+        import logging
+        from tqdm import tqdm
+    except ImportError:
+        pass
+    else:
+        logging.getLogger('requests').setLevel(logging.CRITICAL)
+        logging.getLogger('urllib3').setLevel(logging.CRITICAL)
+        print("\n-- Checking for invalid PUBCHEM CIDs in grounding map --")
+        pubchem_url = 'https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/' + \
+                      'cid/%s/description/XML'
+
+        pubchem_ids = {
+            db_id
+            for text, db_refs in gm.items()
+            for db_key, db_id in db_refs.items()
+            if db_key == 'PUBCHEM'
+        }
+        for db_id in tqdm(pubchem_ids):
+            res = requests.get(pubchem_url % db_id)
+            if res.status_code != 200:
+                print("ERROR: ID %s in grounding map is "
+                      "not a valid PUBCHEM ID." % db_id)
+
+    sys.exit(1 if signal_error else 0)
+
+
+if __name__ == '__main__':
+    main()
diff --git a/famplex/constants.py b/famplex/constants.py
new file mode 100644
index 000000000..50a007d44
--- /dev/null
+++ b/famplex/constants.py
@@ -0,0 +1,16 @@
+# -*- coding: utf-8 -*-
+
+"""Constants for the FamPlex Python package."""
+
+import os
+
+HERE = os.path.abspath(os.path.dirname(__file__))
+
+RESOURCES = os.path.join(HERE, 'resources')
+ENTITIES_PATH = os.path.join(RESOURCES, 'entities.csv')
+EQUIVALENCES_PATH = os.path.join(RESOURCES, 'equivalences.csv')
+GROUNDING_MAP_PATH = os.path.join(RESOURCES, 'grounding_map.csv')
+RELATIONS_PATH = os.path.join(RESOURCES, 'relations.csv')
+METADATA_PATH = os.path.join(RESOURCES, 'metadata.json')
+
+EXPORT_DIR = os.path.abspath(os.path.join(HERE, os.pardir, 'export'))
diff --git a/famplex/export/__init__.py b/famplex/export/__init__.py
new file mode 100644
index 000000000..44ad38158
--- /dev/null
+++ b/famplex/export/__init__.py
@@ -0,0 +1,3 @@
+# -*- coding: utf-8 -*-
+
+"""Export scripts for FamPlex."""
diff --git a/famplex/export/__main__.py b/famplex/export/__main__.py
new file mode 100644
index 000000000..fec3eea57
--- /dev/null
+++ b/famplex/export/__main__.py
@@ -0,0 +1,8 @@
+# -*- coding: utf-8 -*-
+
+"""A command line interface for FamPlex exporters."""
+
+from famplex.export.cli import main
+
+if __name__ == '__main__':
+    main()
diff --git a/famplex/export/cli.py b/famplex/export/cli.py
new file mode 100644
index 000000000..4b557b7c8
--- /dev/null
+++ b/famplex/export/cli.py
@@ -0,0 +1,22 @@
+# -*- coding: utf-8 -*-
+
+"""A command line interface for FamPlex exporters."""
+
+import famplex.export.export_belns
+import famplex.export.export_obo
+import famplex.export.export_relations_graph
+
+__all__ = [
+    'main',
+]
+
+
+def main() -> None:
+    """Export FamPlex to all file types."""
+    famplex.export.export_belns.main()
+    famplex.export.export_obo.main()
+    famplex.export.export_relations_graph.main()
+
+
+if __name__ == '__main__':
+    main()
diff --git a/export/belns.py b/famplex/export/export_belns.py
similarity index 59%
rename from export/belns.py
rename to famplex/export/export_belns.py
index 0272f4074..b2f970b88 100644
--- a/export/belns.py
+++ b/famplex/export/export_belns.py
@@ -1,24 +1,34 @@
-#! /usr/bin/env python3
 # -*- coding: utf-8 -*-
 
-"""Output FamPlex as a BEL namespace. Requires the `bel_resources` package."""
+"""Output FamPlex as a BEL namespace using the :mod:`bel_resources` package."""
 
+import csv
 import os
 
 from bel_resources import write_namespace
 from bel_resources.constants import NAMESPACE_DOMAIN_GENE
 
-path_this = os.path.dirname(os.path.abspath(__file__))
-entities_file = os.path.join(path_this, os.pardir, 'entities.csv')
-output_file = os.path.join(path_this, 'famplex.belns')
+from famplex.constants import ENTITIES_PATH, EXPORT_DIR
+
+DEFAULT_BELNS_PATH = os.path.join(EXPORT_DIR, 'famplex.belns')
 
 
 def _get_entities():
-    with open(entities_file, 'r') as fh:
-        return {l.strip(): 'GRPC' for l in fh.readlines()}
+    with open(ENTITIES_PATH) as file:
+        reader = csv.reader(
+            file,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        return {
+            fplx_name: 'GRPC'
+            for _, fplx_name, _, _ in reader
+        }
 
 
-def _write_namespace(values):
+def _write_namespace(values, output_file):
     with open(output_file, 'w') as file:
         write_namespace(
             namespace_name='FamPlex',
@@ -38,6 +48,10 @@ def _write_namespace(values):
         )
 
 
-if __name__ == '__main__':
+def main(output_file=DEFAULT_BELNS_PATH):
     entities = _get_entities()
-    _write_namespace(entities)
+    _write_namespace(entities, output_file)
+
+
+if __name__ == '__main__':
+    main()
diff --git a/famplex/export/export_obo.py b/famplex/export/export_obo.py
new file mode 100644
index 000000000..3f4688dbe
--- /dev/null
+++ b/famplex/export/export_obo.py
@@ -0,0 +1,231 @@
+import collections
+import csv
+import datetime
+import os
+
+from famplex.constants import (
+    ENTITIES_PATH, EQUIVALENCES_PATH, EXPORT_DIR, GROUNDING_MAP_PATH, RELATIONS_PATH,
+)
+
+DEFAULT_OBO_PATH = os.path.join(EXPORT_DIR, 'famplex.obo')
+
+Synonym = collections.namedtuple('Synonym', ['name', 'status'])
+
+
+class Reference:
+    def __init__(self, db, identifier, name=None):
+        self.db = db
+        self.id = identifier
+        self.name = name
+
+
+ROOT_REFERENCE = Reference('FPLX', '000000', 'famplex')
+
+
+class OboTerm:
+    def __init__(
+            self,
+            *,
+            term_id,
+            description=None,
+            references=None,
+            rels=None,
+            synonyms=None,
+            xrefs=None,
+    ):
+        self.term_id = term_id
+        self.description = description
+        self.references = references
+        self.rels = rels or {}
+        self.synonyms = synonyms or []
+        self.xrefs = xrefs or []
+
+    def to_obo(self):
+        obo_str = '[Term]\n'
+        obo_str += 'id: %s:%s\n' % (self.term_id.db, self.term_id.id)
+        obo_str += 'name: %s\n' % self.term_id.name
+        if self.description is not None:
+            obo_str += 'def: "%s" [%s]\n' % (self.description, ','.join(self.references))
+
+        for synonym in self.synonyms:
+            obo_str += 'synonym: "%s" %s []\n' % (synonym.name, synonym.status)
+
+        for xref in self.xrefs:
+            if xref.db == 'BEL':
+                entry = 'BEL:"%s"' % xref.id
+            elif xref.db == 'NXP':
+                entry = 'NEXTPROT-FAMILY:%s' % xref.id[3:]
+            elif xref.db == 'PF':
+                entry = 'XFAM:%s' % xref.id
+            elif xref.db == 'GO':
+                entry = xref.id
+            else:
+                entry = '%s:%s' % (xref.db, xref.id)
+
+            if xref.name is not None:
+                entry += f' ! {xref.name}'
+
+            obo_str += 'xref: %s\n' % entry
+
+        for rel_type, rel_entries in self.rels.items():
+            for ref in rel_entries:
+                if rel_type == 'is_a':
+                    obo_str += '%s: %s:%s' % (rel_type, ref.db, ref.id)
+                else:
+                    obo_str += 'relationship: %s %s:%s' % (rel_type, ref.db, ref.id)
+                if ref.name is not None:
+                    obo_str += f' ! {ref.name}'
+                obo_str += '\n'
+
+        return obo_str
+
+    def __str__(self):
+        return self.to_obo()
+
+
+ROOT_OBO_TERM = OboTerm(term_id=ROOT_REFERENCE)
+
+
+def get_obo_terms():
+    obo_terms = [ROOT_OBO_TERM]
+
+    with open(ENTITIES_PATH) as fh:
+        reader = csv.reader(
+            fh,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        entities = {
+            fplx_id: (
+                fplx_name,
+                None if not description or description == '.' else description,
+                None if not references or references == '.' else [r.strip() for r in references.split(',')],
+            )
+            for fplx_id, fplx_name, description, references in reader
+        }
+
+    with open(EQUIVALENCES_PATH, 'r') as fh:
+        reader = csv.reader(
+            fh,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        equivalences = collections.defaultdict(list)
+        for xref_db, xref_id, fplx_id, _ in reader:
+            equivalences[fplx_id].append((xref_db, xref_id))
+
+    with open(GROUNDING_MAP_PATH) as fh:
+        reader = csv.reader(
+            fh,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        textrefs = collections.defaultdict(list)
+        for textref, db, db_id, _ in reader:
+            if db == 'FPLX':
+                textrefs[db_id].append(textref)
+
+    with open(RELATIONS_PATH) as fh:
+        rels = {
+            entity: collections.OrderedDict(
+                is_a=[],
+                part_of=[],
+                inverse_is_a=[],
+                has_part=[],
+            )
+            for entity in entities
+        }
+        reader = csv.reader(
+            fh,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        for sub_db, sub_id, sub_name, rel, obj_db, obj_id, obj_name in reader:
+            if sub_db == 'FPLX':
+                if rel == 'isa':
+                    rels[sub_id]['is_a'].append(Reference(obj_db, obj_id, obj_name))
+                elif rel == 'partof':
+                    rels[sub_id]['part_of'].append(Reference(obj_db, obj_id, obj_name))
+            if obj_db == 'FPLX':
+                if rel == 'isa':
+                    rels[obj_id]['inverse_is_a'].append(Reference(sub_db, sub_id, sub_name))
+                elif rel == 'partof':
+                    rels[obj_id]['has_part'].append(Reference(sub_db, sub_id, sub_name))
+
+    # For each entity in famplex
+    for fplx_id, (fplx_name, description, references) in entities.items():
+        name = fplx_name.replace('_', '-')
+
+        term_id = Reference('FPLX', fplx_id, name)
+
+        synonyms = [  # Get synonyms
+            Synonym(textref, 'EXACT')
+            for textref in textrefs.get(fplx_id, [])
+        ]
+
+        xrefs = [  # Get xrefs
+            Reference(xref_db, xref_id)
+            for xref_db, xref_id in equivalences.get(fplx_id, [])
+        ]
+        # If the entity has no isa relations, connect it to the root
+        if not rels[fplx_id]['is_a'] and not rels[fplx_id]['part_of']:
+            rels[fplx_id]['is_a'].append(ROOT_REFERENCE)
+
+        obo_term = OboTerm(
+            term_id=term_id,
+            description=description,
+            references=references,
+            rels=rels[fplx_id],
+            synonyms=synonyms,
+            xrefs=xrefs,
+        )
+        obo_terms.append(obo_term)
+
+    return obo_terms
+
+
+def save_obo_terms(obo_terms, output_file):
+    date = datetime.datetime.today()
+    date_str = date.strftime('%d:%m:%Y %H:%M')
+    with open(output_file, 'w') as fh:
+        fh.write('format-version: 1.2\n')
+        fh.write('date: %s\n' % date_str)
+        fh.write(""" 
+[Typedef]
+id: part_of
+name: part of
+namespace: external
+xref: BFO:0000050
+is_transitive: true
+
+[Typedef]
+id: inverse_is_a
+name: inverse is_a
+
+[Typedef]
+id: has_part
+name: has part
+
+""")
+
+        for term in obo_terms:
+            obo_str = term.to_obo()
+            fh.write(obo_str)
+            fh.write('\n')
+
+
+def main():
+    obo_terms = get_obo_terms()
+    save_obo_terms(obo_terms, DEFAULT_OBO_PATH)
+
+
+if __name__ == '__main__':
+    main()
diff --git a/famplex/export/export_relations_graph.py b/famplex/export/export_relations_graph.py
new file mode 100644
index 000000000..380583c56
--- /dev/null
+++ b/famplex/export/export_relations_graph.py
@@ -0,0 +1,55 @@
+import csv
+import os
+
+import pygraphviz as pgv
+
+from famplex.constants import EXPORT_DIR, RELATIONS_PATH
+
+DEFAULT_RELATIONS_GRAPH_PATH = os.path.join(EXPORT_DIR, 'relations_graph.pdf')
+
+HGNC_STYLE = {
+    'color': 'lightgray',
+    'style': 'filled',
+    'fontname': 'arial',
+}
+FAMPLEX_STYLE = {
+    'color': 'pink',
+    'style': 'filled',
+    'fontname': 'arial',
+}
+EDGE_STYLE = {
+    'fontname': 'arial',
+}
+
+
+def node_label(db, db_id, name):
+    return '%s:%s ! %s' % (db, db_id, name)
+
+
+def main(output_file=DEFAULT_RELATIONS_GRAPH_PATH):
+    graph = pgv.AGraph(name='relations', directed=True, rankdir='LR')
+
+    with open(RELATIONS_PATH) as file:
+        reader = csv.reader(
+            file,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        for ns1, id1, name1, rel, ns2, id2, name2 in reader:
+            sub, obj = node_label(ns1, id1, name1), node_label(ns2, id2, name2)
+
+            for db, label in ((ns1, sub), (ns2, obj)):
+                if db == 'HGNC':
+                    graph.add_node(label, **HGNC_STYLE)
+                elif db == 'FPLX':
+                    graph.add_node(label, **FAMPLEX_STYLE)
+
+            graph.add_edge(sub, obj, label=rel, **EDGE_STYLE)
+
+    graph.draw(output_file, prog='dot')
+
+
+if __name__ == '__main__':
+    main()
diff --git a/famplex/export/hgnc_ids.py b/famplex/export/hgnc_ids.py
new file mode 100644
index 000000000..545aaedbe
--- /dev/null
+++ b/famplex/export/hgnc_ids.py
@@ -0,0 +1,56 @@
+"""Several files in this resource use HGNC gene symbols to identify individual
+genes. However, the symbols assigned to HGNC IDs can change over time, and
+therefore previously curated symbols can become invalid. This script
+generates a mapping of current (i.e. at the time of running the script)
+mappings of HGNC IDs to symbols so that the assumptions about the identity
+of the genes in the various tables can be traced."""
+
+import csv
+import os
+
+from famplex.constants import EXPORT_DIR, GROUNDING_MAP_PATH, RELATIONS_PATH
+from indra.databases import hgnc_client
+
+HERE = os.path.dirname(os.path.abspath(__file__))
+HGNC_SYMBOL_MAP_PATH = os.path.join(EXPORT_DIR, 'hgnc_symbol_map.csv')
+
+
+def main():
+    hgnc_symbols = set()
+    # Gather all HGNC symbols from relations.csv
+    with open(RELATIONS_PATH) as f:
+        reader = csv.reader(
+            f,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        for ns1, id1, n1, rel, ns2, id2, n2 in reader:
+            if ns1 == 'HGNC':
+                hgnc_symbols.add(n1)
+            if ns2 == 'HGNC':
+                hgnc_symbols.add(n2)
+
+    # Gather all HGNC symbols from grounding_map.csv
+    with open(GROUNDING_MAP_PATH) as f:
+        reader = csv.reader(
+            f,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        for text, db, db_id, db_name in reader:
+            if db == 'HGNC':
+                hgnc_symbols.add(db_name)
+
+    # Create output file
+    with open(HGNC_SYMBOL_MAP_PATH, 'w') as fh:
+        for hgnc_symbol in sorted(list(hgnc_symbols)):
+            hgnc_id = hgnc_client.get_hgnc_id(hgnc_symbol)
+            fh.write('%s,%s\r\n' % (hgnc_symbol, hgnc_id))
+
+
+if __name__ == '__main__':
+    main()
diff --git a/famplex/reorganize_old_resources.py b/famplex/reorganize_old_resources.py
new file mode 100644
index 000000000..d25877532
--- /dev/null
+++ b/famplex/reorganize_old_resources.py
@@ -0,0 +1,212 @@
+# -*- coding: utf-8 -*-
+
+"""This script upgrades all of the FamPlex CSV files."""
+
+import csv
+import json
+import os
+import time
+from collections import Counter
+from operator import itemgetter
+from typing import Tuple
+
+from famplex.constants import (
+    ENTITIES_PATH, EQUIVALENCES_PATH, GROUNDING_MAP_PATH, METADATA_PATH,
+    RELATIONS_PATH,
+)
+from indra.databases import chebi_client, go_client, hgnc_client, mesh_client, mirbase_client, uniprot_client
+
+HERE = os.path.abspath(os.path.dirname(__file__))
+
+# Input paths
+INPUT_RESOURCES = os.path.join(HERE, os.pardir)
+ENTITIES_CSV_PATH = os.path.join(INPUT_RESOURCES, 'entities.csv')
+EQUIVALENCES_CSV_PATH = os.path.join(INPUT_RESOURCES, 'equivalences.csv')
+GROUNDING_MAP_CSV_PATH = os.path.join(INPUT_RESOURCES, 'grounding_map.csv')
+RELATIONS_CSV_PATH = os.path.join(INPUT_RESOURCES, 'relations.csv')
+DESCRIPTIONS_CSV_PATH = os.path.join(INPUT_RESOURCES, 'descriptions.csv')
+
+FAMPLEX_DESCRIPTION = 'A protein family, complex, family of complexes,or complex of families'
+
+client_id_lookups = [
+    ('HGNC', hgnc_client.get_hgnc_id),
+]
+
+client_name_lookups = [
+    ('UP', uniprot_client.get_mnemonic),
+    ('GO', go_client.get_go_label),
+    ('MESH', mesh_client.get_mesh_name),
+    ('MIRBASE', mirbase_client.get_mirbase_name_from_mirbase_id),
+    ('CHEBI', chebi_client.get_chebi_name_from_id),
+]
+
+
+def main():
+    fplx_name_to_id = {}
+
+    def get_id_label(db: str, db_id: str) -> Tuple[str, str]:
+        if db == 'FPLX':
+            return fplx_name_to_id[db_id], db_id
+
+        for client, lookup in client_id_lookups:
+            if db == client:
+                return lookup(db_id), db_id
+
+        for client, lookup in client_name_lookups:
+            if db == client:
+                return db_id, lookup(db_id)
+
+        else:
+            return db_id, ''
+
+    with open('descriptions.csv') as in_file:
+        reader = csv.reader(
+            in_file,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        fplx_name_to_description = {
+            fplx_name: (
+                description,
+                [r.strip() for r in references.split(';')],
+            )
+            for fplx_name, references, description in reader
+        }
+
+    with open('entities.csv') as in_file, open(ENTITIES_PATH, 'w') as out_file:
+        writer = csv.writer(
+            out_file,
+            delimiter=',',
+            quotechar='"',
+            quoting=csv.QUOTE_MINIMAL,
+            lineterminator='\r\n',
+        )
+        for i, fplx_name in enumerate(in_file, start=1):
+            fplx_name = fplx_name.strip()
+            fplx_id = fplx_name_to_id[fplx_name] = f'{i:06}'
+            description, references = fplx_name_to_description.get(fplx_name, (None, None))
+            writer.writerow((
+                fplx_id,
+                fplx_name,
+                description if description is not None else '',
+                ','.join(references) if references is not None else '',
+            ))
+
+    with open('equivalences.csv') as in_file, open(EQUIVALENCES_PATH, 'w') as out_file:
+        # print('xref_db', 'xref_id', 'fplx_id', 'fplx_name', sep='\t', file=out_file)
+        reader = csv.reader(
+            in_file,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        writer = csv.writer(
+            out_file,
+            delimiter=',',
+            quotechar='"',
+            quoting=csv.QUOTE_MINIMAL,
+            lineterminator='\r\n',
+        )
+        for xref_db, xref_name, fplx_name in reader:
+            writer.writerow((
+                xref_db,
+                xref_name,
+                fplx_name_to_id[fplx_name],
+                fplx_name,
+            ))
+
+    groundings_unlabelled = set()
+    with open('grounding_map.csv') as in_file, open(GROUNDING_MAP_PATH, 'w') as out_file:
+        reader = csv.reader(
+            in_file,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        writer = csv.writer(
+            out_file,
+            delimiter=',',
+            quotechar='"',
+            quoting=csv.QUOTE_MINIMAL,
+            lineterminator='\r\n',
+        )
+        for text, *line in reader:
+            for xref_db, identifier in zip(line[::2], line[1::2]):
+                if not xref_db or not identifier:
+                    continue
+
+                identifier, xref_name = get_id_label(xref_db, identifier)
+                if not xref_name:
+                    groundings_unlabelled.add((xref_db, identifier))
+
+                writer.writerow((text, xref_db, identifier, xref_name))
+
+    # Logging for unlabelled entities
+    if groundings_unlabelled:
+        print(f'\n{len(groundings_unlabelled)} groundings are unlabelled:')
+        grounding_unlabelled_counter = Counter(map(itemgetter(0), groundings_unlabelled))
+        s = max(map(len, grounding_unlabelled_counter))
+        for xref_db, count in grounding_unlabelled_counter.most_common():
+            print(f'{xref_db:>{s}s} unlabelled {count}')
+
+    relations_unlabelled = set()
+    with open('relations.csv') as in_file, open(RELATIONS_PATH, 'w') as out_file:
+        # print('sub_db', 'sub_id', 'sub_name', 'rel',
+        #      'obj_db', 'obj_id', 'obj_name', sep='\t', file=out_file)
+
+        reader = csv.reader(
+            in_file,
+            delimiter=',',
+            lineterminator='\r\n',
+            quoting=csv.QUOTE_MINIMAL,
+            quotechar='"',
+        )
+        writer = csv.writer(
+            out_file,
+            delimiter=',',
+            quotechar='"',
+            quoting=csv.QUOTE_MINIMAL,
+            lineterminator='\r\n',
+        )
+        for sub_db, sub_id, rel, obj_db, obj_id in reader:
+            sub_id, sub_name = get_id_label(sub_db, sub_id)
+            if not sub_name:
+                relations_unlabelled.add((sub_db, sub_id))
+
+            obj_id, obj_name = get_id_label(obj_db, obj_id)
+            if not obj_name:
+                relations_unlabelled.add((obj_db, obj_id))
+
+            writer.writerow((
+                sub_db, sub_id, sub_name, rel,
+                obj_db, obj_id, obj_name
+            ))
+
+    if relations_unlabelled:  # Logging for unlabelled entities
+        print(f'\n{len(relations_unlabelled)} relations are unlabelled:')
+        relations_unlabelled_counter = Counter(map(itemgetter(0), relations_unlabelled))
+        s = max(map(len, relations_unlabelled_counter))
+        for xref_db, count in relations_unlabelled_counter.most_common():
+            print(f'{xref_db:>{s}s} unlabelled {count}')
+
+    metadata = {
+        'Time Exported': str(time.asctime()),
+        'Unlabelled Groundings': [
+            dict(db=db, db_id=db_id)
+            for db, db_id in sorted(groundings_unlabelled)
+        ],
+        'Unlabelled Relations': [
+            dict(db=db, db_id=db_id)
+            for db, db_id in sorted(relations_unlabelled)
+        ]
+    }
+    with open(METADATA_PATH, 'w') as file:
+        json.dump(metadata, file, indent=2, sort_keys=True)
+
+
+if __name__ == '__main__':
+    main()
diff --git a/famplex/resources/entities.csv b/famplex/resources/entities.csv
new file mode 100644
index 000000000..a25a3f801
--- /dev/null
+++ b/famplex/resources/entities.csv
@@ -0,0 +1,505 @@
+000001,9_1_1,,
+000002,A4GALT_family,,
+000003,ABL_family,,
+000004,ACAD,,
+000005,ACC,,
+000006,Acetyl_CoA_synthetase,,
+000007,ACOX,,
+000008,ACSL,,
+000009,Actin,,
+000010,Activin,,
+000011,Activin_A,,
+000012,Activin_AB,,
+000013,Activin_B,,
+000014,ACTN,,
+000015,Adaptor_protein_II,,
+000016,Adaptor_protein_III,,
+000017,ADCY,,
+000018,ADH,,
+000019,ADRA,,
+000020,ADRA2,,
+000021,ADRB,,
+000022,ADRBK,,
+000023,AKT,,
+000024,ALDH,,
+000025,ALDO,,
+000026,ALG10,,
+000027,ALG1_family,,
+000028,ALG3_family,,
+000029,ALG6_family,,
+000030,ALG13_family,,
+000031,AMPK,,
+000032,AMPK_A1B1G1,,
+000033,AMPK_A1B1G2,,
+000034,AMPK_A1B1G3,,
+000035,AMPK_A1B2G1,,
+000036,AMPK_A1B2G2,,
+000037,AMPK_A1B2G3,,
+000038,AMPK_A2B1G1,,
+000039,AMPK_A2B1G2,,
+000040,AMPK_A2B1G3,,
+000041,AMPK_A2B2G1,,
+000042,AMPK_A2B2G2,,
+000043,AMPK_A2B2G3,,
+000044,AMPK_alpha,,
+000045,AMPK_beta,,
+000046,AMPK_gamma,,
+000047,Annexin_II_heterotetramer,,
+000048,AP1,,
+000049,AP2A,,
+000050,APC_C,,
+000051,APOA,,
+000052,Apolipoprotein,,
+000053,ARF_GTPase_family,,
+000054,Arp2_3_protein,,
+000055,ARRB,,
+000056,ATG4,,
+000057,ATP1A,,
+000058,ATP1B,,
+000059,ATP5G,,
+000060,ATP_synthase,,
+000061,Augmin,,
+000062,AXIN,,
+000063,B3GAT,,
+000064,BCKDC,,
+000065,Beta_3_4_GTF,,
+000066,BIRC,,
+000067,BMP,,
+000068,BMP_receptor,,
+000069,BMP_receptor_type_I,,
+000070,BMP_receptor_type_II,,
+000071,BRCA,,
+000072,C1,,
+000073,C1q,,
+000074,Cadherin,,
+000075,CALM,,
+000076,CAMK,,
+000077,CAMK2_complex,,
+000078,CAMK2_family,,
+000079,CAPN,,
+000080,Carboxylesterase,,
+000081,Caspase,,
+000082,Caspase_3_7,,
+000083,CAV,,
+000084,CBF3,SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex,interpro:IPR016072
+000085,CCT_complex,,
+000086,CD16,,
+000087,CD3,,
+000088,CD32,,
+000089,CD64,,
+000090,CD8,,
+000091,CDC25,,
+000092,CDK,,
+000093,CDK1_2,,
+000094,CDKN,,
+000095,CDKN1,,
+000096,CDKN2,,
+000097,CEBP,,
+000098,CHEK,,
+000099,Chemokine,,
+000100,Chemokine_receptor,,
+000101,Cholinesterase,,
+000102,CHRM,,
+000103,CHRN,,
+000104,CK2,,
+000105,Clathrin,,
+000106,CNKSR,,
+000107,Cofilin,,
+000108,Cohesin,,
+000109,COL1,,
+000110,COL4,,
+000111,COL5,,
+000112,COLGALT,,
+000113,COX,,
+000114,COX4,,
+000115,COX6A,,
+000116,COX6B,,
+000117,COX7A,,
+000118,COX7B,,
+000119,COX8,,
+000120,CREB,,
+000121,CRISP,,
+000122,CRSP,,
+000123,CRTC,,
+000124,CSNK1,,
+000125,CSNK2,,
+000126,CTNNA,,
+000127,CUL,,
+000128,CXCL_ELR_negative,,
+000129,CXCL_ELR_positive,,
+000130,Cyclin,,
+000131,Cyclin_A,,
+000132,Cyclin_D,,
+000133,Cyclin_E,,
+000134,Cyclophilin,,
+000135,Cytoplasmic_dynein,,
+000136,DDR,,
+000137,Death_receptor,,
+000138,Desmoglein,,
+000139,DGC,,
+000140,DGK,,
+000141,DNA_polymerase_delta,,
+000142,DNM,,
+000143,DRD,,
+000144,DUSP,,
+000145,DVL,,
+000146,DYRK,,
+000147,E2F,,
+000148,E3_Ub_ligase,,
+000149,EDN,,
+000150,EGFR_ligand,,
+000151,EGR,,
+000152,EIF2B,,
+000153,EIF4A,,
+000154,EIF4EBP,,
+000155,EIF4G,,
+000156,ELA,,
+000157,ENO,,
+000158,Ephrin_receptor,,
+000159,EPN,,
+000160,ERBB,,
+000161,ERK,,
+000162,ESR,,
+000163,ETS,,
+000164,EXOC,,
+000165,EXT,,
+000166,FANC,,
+000167,FGF,,
+000168,FGFR,,
+000169,Fibrinogen,,
+000170,FLOT,,
+000171,FLRT,,
+000172,FNT,,
+000173,FOS_family,,
+000174,FOXO,,
+000175,FSH,,
+000176,FUT,,
+000177,FZD,,
+000178,F_actin,,
+000179,GABR,,
+000180,GALNT,,
+000181,Gamma_secretase,,
+000182,GAP,,
+000183,GAS6_receptor,,
+000184,GATA,,
+000185,GCNT,,
+000186,GEF,,
+000187,GPCR,,
+000188,GPIb_IX_V,,
+000189,GPIT,,
+000190,GPX,,
+000191,GRIA,,
+000192,GRK,,
+000193,GRM,,
+000194,GSK3,,
+000195,GST,,
+000196,GTF2E,,
+000197,GTF2F,,
+000198,Glycosyltransferase,,
+000199,GTF_family_2,,
+000200,GTF_family_6,,
+000201,GTF_family_8,,
+000202,GTF_family_29,,
+000203,GTF_family_90,,
+000204,GTPase,,
+000205,GUCY,,
+000206,GYS,,
+000207,G_12,,
+000208,G_12_alpha,,
+000209,G_alpha,,
+000210,G_beta,,
+000211,G_gamma,,
+000212,G_i,,
+000213,G_i_alpha,,
+000214,G_protein,,
+000215,G_q,,
+000216,G_q_alpha,,
+000217,G_s,,
+000218,G_s_alpha,,
+000219,hCG,,
+000220,HDAC,,
+000221,HDAC_I,,
+000222,HDAC_II,,
+000223,HDAC_III,,
+000224,HDAC_IV,,
+000225,HDL,,
+000226,Hedgehog,,
+000227,Hemoglobin,,
+000228,HES,,
+000229,HIF,,
+000230,HIF1,,
+000231,HIF_alpha,,
+000232,HIF_beta,,
+000233,Histone,,
+000234,Histone_H1,,
+000235,Histone_H2A,,
+000236,Histone_H2B,,
+000237,Histone_H3,,
+000238,Histone_H4,,
+000239,HLA_DR,,
+000240,HMOX,,
+000241,HSP90,,
+000242,HSP90A,,
+000243,HSP90AA,,
+000244,HSPA,,
+000245,HSPB,,
+000246,IFNA,,
+000247,IFNB,,
+000248,IGFBP,,
+000249,IKB,,
+000250,IKK_complex,,
+000251,IKK_family,,
+000252,IL1,,
+000253,IL12,,
+000254,IL15R,,
+000255,IL2R,,
+000256,Inhibin,,
+000257,Inhibin_A,,
+000258,Inhibin_B,,
+000259,INS,,
+000260,INSR,,
+000261,Integrins,,
+000262,Interferon,,
+000263,Interferon_gamma_receptor,,
+000264,IRS,,
+000265,IRX,,
+000266,JAK,,
+000267,JNK,,
+000268,JUN_family,,
+000269,Kainate_family,,
+000270,Kinetochore,,
+000271,KLK,,
+000272,KSR,,
+000273,Laminin_111,,
+000274,Laminin_332,,
+000275,LDH,,
+000276,LH,,
+000277,LPAR,,
+000278,MAC,,
+000279,MAF,,
+000280,MAP1LC3,,
+000281,MAP2K,,
+000282,MAP3K,,
+000283,MAPK,,
+000284,MCM,,
+000285,MEF2,,
+000286,MEK,,
+000287,MGAT,,
+000288,Mitochondrial_Ribosome,,
+000289,MRPS,,
+000290,MRPL,,
+000291,MMP,,
+000292,Metallothionein,,
+000293,mTORC1,,
+000294,mTORC2,,
+000295,MYH,,
+000296,MYL,,
+000297,MYL_alkali,,
+000298,MYL_regulatory,,
+000299,MYL_slow,,
+000300,MYST,,
+000301,NADH_dehydrogenase,,
+000302,NADPH_oxidase,,
+000303,Na_K_ATPase,,
+000304,Natriuretic_peptide,,
+000305,NCOA,,
+000306,NCOR,,
+000307,NDRG,,
+000308,Neurexins,,
+000309,NFAT,,
+000310,NFE,,
+000311,NFkappaB,,
+000312,NFkappaB_1,,
+000313,NFkappaB_2,,
+000314,NFY,,
+000315,NKD,,
+000316,NOS,,
+000317,Notch,,
+000318,NRG,,
+000319,NRG_1_2,,
+000320,NRG_3_4,,
+000321,NTRK,,
+000322,OGT_family,,
+000323,p14_3_3,,
+000324,P2RX,,
+000325,P2RY,,
+000326,p38,,
+000327,p53_family,,
+000328,P70S6K,,
+000329,P90RSK,,
+000330,PAK,,
+000331,PARP,,
+000332,PARV,,
+000333,Patched,,
+000334,PBX,,
+000335,PDE,,
+000336,PDE1,,
+000337,PDE3,,
+000338,PDE4,,
+000339,PDE6,,
+000340,PDE7,,
+000341,PDE8,,
+000342,PDGF,,
+000343,PDGFR,,
+000344,PDGFR_AA,,
+000345,PDGFR_AB,,
+000346,PDGFR_BB,,
+000347,PDGF_AA,,
+000348,PDGF_AB,,
+000349,PDGF_BB,,
+000350,PDGF_CC,,
+000351,PDGF_DD,,
+000352,PDH,,
+000353,PDK,,
+000354,Pertussis_toxin,,
+000355,PFN,,
+000356,PhK,,
+000357,Phosphatase,,
+000358,PI3K,,
+000359,PI3K_p110,,
+000360,PI3K_p85,,
+000361,PIK3R_I,,
+000362,PIM,,
+000363,PKA,,
+000364,PKC,,
+000365,PKI,,
+000366,PLA2,,
+000367,PLA2G2,,
+000368,PLA2G4,,
+000369,PLC,,
+000370,PLCB,,
+000371,PLCD,,
+000372,PLCG,,
+000373,PLD,,
+000374,PPAP2,,
+000375,PPAR,,
+000376,PPP1,,
+000377,PPP1C,,
+000378,PPP1R,,
+000379,PPP2,,
+000380,PPP2C,,
+000381,PPP2R_A,,
+000382,PPP2R_B,,
+000383,PPP3,,
+000384,PPP3C,,
+000385,PPP3R,,
+000386,PRC1_complex,,
+000387,PRC2_complex,,
+000388,PRDX,,
+000389,PRKAC,,
+000390,PRKAR,,
+000391,PRKG,,
+000392,Propionyl_CoA_carboxylase,,
+000393,Protease,,
+000394,Proteasome,,
+000395,PTGER,,
+000396,PYG,,
+000397,RAB,,
+000398,RAC,,
+000399,RAF,,
+000400,RAL,,
+000401,RAP1,,
+000402,RAPGEF,,
+000403,RAR,,
+000404,RAS,,
+000405,RASA,,
+000406,RASAL,,
+000407,RasGAP,,
+000408,RASGRF,,
+000409,RASGRP,,
+000410,RASSF,,
+000411,RFC,,
+000412,RFX,,
+000413,RGL,,
+000414,RHO,,
+000415,RhoGDI,,
+000416,RNApo_I,,
+000417,RNApo_II,,
+000418,ROBO,,
+000419,ROCK,,
+000420,ROR,,
+000421,RPA,,
+000422,RSK,,
+000423,RTK,,
+000424,RXR,,
+000425,S100,,
+000426,S100A,,
+000427,S1PR,,
+000428,SAA,,
+000429,SCD,,
+000430,SERCA,,
+000431,SERPINB,,
+000432,SHC,,
+000433,SIK,,
+000434,SLC2A,,
+000435,SLRP,,
+000436,SLRP_1,,
+000437,SLRP_2,,
+000438,SLRP_3,,
+000439,SLRP_4,,
+000440,SLRP_5,,
+000441,SMAD,,
+000442,SMAD1_5_9,,
+000443,SMAD2_3,,
+000444,SMC1,,
+000445,SMURF,,
+000446,SNAI,,
+000447,SOD,,
+000448,SOS,,
+000449,SPRED,,
+000450,SPRY,,
+000451,SRC,,
+000452,SREBF,,
+000453,STAT,,
+000454,STAT5,,
+000455,STT3,,
+000456,Sulfonylurea_receptor,,
+000457,SWI_SNF,,
+000458,TAOK,,
+000459,TAP,,
+000460,TCF_LEF,,
+000461,TCR,,
+000462,TEAD,,
+000463,TFAP2,,
+000464,TFDP,,
+000465,TGFB,,
+000466,TGFBR,,
+000467,THBS,,
+000468,THR,,
+000469,Thrombin_antithrombin,,
+000470,TIAM,,
+000471,TIF_IB,,
+000472,TLR,,
+000473,TN,,
+000474,TNF,,
+000475,TNFRSF,,
+000476,TOP2,,
+000477,Troponin,,
+000478,Troponin_C,,
+000479,Troponin_I,,
+000480,Troponin_T,,
+000481,Tryptase,,
+000482,TSC,,
+000483,TUBA,,
+000484,TUBB,,
+000485,TUBG,,
+000486,Tubulin,,
+000487,TXN,,
+000488,TXNRD,,
+000489,UBE2,,
+000490,Ubiquitin,,
+000491,UGCG,,
+000492,UGT,,
+000493,UGGT,,
+000494,VAV,,
+000495,VEGF,,
+000496,VEGFR,,
+000497,Wnt,,
+000498,YBX,,
+000499,ETC_complex_I_core,,
+000500,ETC_complex_I_supernumerary,,
+000501,ETC_complex_I,,
+000502,ETC_complex_II,,
+000503,ETC_complex_III,,
+000504,ETC_complex_IV,,
+000505,ETC_complex_V,,
diff --git a/famplex/resources/equivalences.csv b/famplex/resources/equivalences.csv
new file mode 100644
index 000000000..86383dda2
--- /dev/null
+++ b/famplex/resources/equivalences.csv
@@ -0,0 +1,1582 @@
+BEL,14-3-3 Family,000323,p14_3_3
+BEL,9-1-1 Complex,000001,9_1_1
+BEL,ACAD Family,000004,ACAD
+BEL,Acetyl CoA Carboxylase Complex,000005,ACC
+BEL,Acetyl-CoA Synthetase Family,000006,Acetyl_CoA_synthetase
+BEL,ACOX Family,000007,ACOX
+BEL,ACSL Family,000008,ACSL
+BEL,ACT Family,000009,Actin
+BEL,ACTN Family,000014,ACTN
+BEL,Adaptor Protein II Complex,000015,Adaptor_protein_II
+BEL,Adaptor Protein III Complex,000016,Adaptor_protein_III
+BEL,ADCY Family,000017,ADCY
+BEL,ADH Family,000018,ADH
+BEL,ADRA Family,000019,ADRA
+BEL,ADRA2 Family,000020,ADRA2
+BEL,ADRB Family,000021,ADRB
+BEL,ADRBK Family,000022,ADRBK
+BEL,AKT Family,000023,AKT
+BEL,ALDH Family,000024,ALDH
+BEL,ALDO Family,000025,ALDO
+BEL,AMP Activated Protein Kinase Complex,000031,AMPK
+BEL,Annexin II Heterotetramer Complex,000047,Annexin_II_heterotetramer
+BEL,AP-1 Complex,000048,AP1
+BEL,APOA Family,000051,APOA
+BEL,Arp2/3 Protein Complex,000054,Arp2_3_protein
+BEL,ARRB Family,000055,ARRB
+BEL,ATP2A Family,000430,SERCA
+BEL,ATP5G Family,000059,ATP5G
+BEL,AXIN Family,000062,AXIN
+BEL,BIRC Family,000066,BIRC
+BEL,BMP Family,000067,BMP
+BEL,BMP Receptor Type I Family,000069,BMP_receptor_type_I
+BEL,BMP Receptor Type II Family,000070,BMP_receptor_type_II
+BEL,Branched Chain Alpha Keto Acid Dehydrogenase Complex,000064,BCKDC
+BEL,C1 Complex,000072,C1
+BEL,C1q Complex,000073,C1q
+BEL,Calcineurin Complex,000383,PPP3
+BEL,CALM Family,000075,CALM
+BEL,CAMK Family,000076,CAMK
+BEL,CAMK2 Complex,000077,CAMK2_complex
+BEL,CAMK2 Family,000078,CAMK2_family
+BEL,CAPN Family,000079,CAPN
+BEL,Carboxylesterase Family,000080,Carboxylesterase
+BEL,CASP Family,000081,Caspase
+BEL,CAV Family,000083,CAV
+BEL,CBF3 Complex,000084,CBF3
+BEL,CCNA Family,000131,Cyclin_A
+BEL,CCND Family,000132,Cyclin_D
+BEL,CCNE Family,000133,Cyclin_E
+BEL,CCT Complex,000085,CCT_complex
+BEL,CD16 Family,000086,CD16
+BEL,CD3 Complex,000087,CD3
+BEL,CD32 Family,000088,CD32
+BEL,CD64 Family,000089,CD64
+BEL,CDC25 Family,000091,CDC25
+BEL,CDH Family,000074,Cadherin
+BEL,CEBP Family,000097,CEBP
+BEL,Chemokine Receptor Family,000100,Chemokine_receptor
+BEL,Cholinesterase Family,000101,Cholinesterase
+BEL,CHRM Family,000102,CHRM
+BEL,CHRN Complex,000103,CHRN
+BEL,CK II Complex,000104,CK2
+BEL,Clathrin Complex,000105,Clathrin
+BEL,Cohesin Complex,000108,Cohesin
+BEL,COL1 Family,000109,COL1
+BEL,COL4 Family,000110,COL4
+BEL,COL5 Family,000111,COL5
+BEL,COX4 Family,000114,COX4
+BEL,COX6A Family,000115,COX6A
+BEL,COX6B Family,000116,COX6B
+BEL,COX7A Family,000117,COX7A
+BEL,COX7B Family,000118,COX7B
+BEL,COX8 Family,000119,COX8
+BEL,CREB Family,000120,CREB
+BEL,CRISP Family,000121,CRISP
+BEL,CRSP Complex,000122,CRSP
+BEL,CSNK1 Family,000124,CSNK1
+BEL,CSNK2 Family,000125,CSNK2
+BEL,CTNNA Family,000126,CTNNA
+BEL,Cu-Zn SOD Family,000447,SOD
+BEL,CUL Family,000127,CUL
+BEL,CXCL ELR-Negative Family,000128,CXCL_ELR_negative
+BEL,CXCL ELR-Positive Family,000129,CXCL_ELR_positive
+BEL,Cyclophilin Family,000134,Cyclophilin
+BEL,Cytochrome C Oxidase Complex Muscle,000113,COX
+BEL,Cytochrome C Oxidase Complex Non Muscle,000113,COX
+BEL,Cytoplasmic Dynein Complex,000135,Cytoplasmic_dynein
+BEL,DDR Family,000136,DDR
+BEL,Desmoglein Family,000138,Desmoglein
+BEL,DGK Family,000140,DGK
+BEL,DNA Polymerase delta Complex,000141,DNA_polymerase_delta
+BEL,DNM Family,000142,DNM
+BEL,DRD Family,000143,DRD
+BEL,DVL Family,000145,DVL
+BEL,Dystrophin Associated Glycoprotein Complex,000139,DGC
+BEL,E2F Family,000147,E2F
+BEL,EDN Family,000149,EDN
+BEL,EGFR Ligand Family,000150,EGFR_ligand
+BEL,EGFR/ERBB Family,000160,ERBB
+BEL,EGR Family,000151,EGR
+BEL,EIF2B Complex,000152,EIF2B
+BEL,EIF4A Family,000153,EIF4A
+BEL,EIF4EBP Family,000154,EIF4EBP
+BEL,ELA Family,000156,ELA
+BEL,ENO Family,000157,ENO
+BEL,Ephrin Receptor Family,000158,Ephrin_receptor
+BEL,EPN Family,000159,EPN
+BEL,ESR Family,000162,ESR
+BEL,ETS Family,000163,ETS
+BEL,FGF Family,000167,FGF
+BEL,FGFR Family,000168,FGFR
+BEL,Fibrinogen Complex,000169,Fibrinogen
+BEL,FLOT Family,000170,FLOT
+BEL,FLRT Family,000171,FLRT
+BEL,Follicle Stimulating Hormone Complex,000175,FSH
+BEL,FOXO Family,000174,FOXO
+BEL,FZD Family,000177,FZD
+BEL,GABR Family,000179,GABR
+BEL,gamma Secretase Complex,000181,Gamma_secretase
+BEL,GAS6 Receptor Family,000183,GAS6_receptor
+BEL,GATA Family,000184,GATA
+BEL,GNA Gq Family,000215,G_q
+BEL,GNA Gs Family,000217,G_s
+BEL,GNAI Family,000212,G_i
+BEL,GNB Family,000210,G_beta
+BEL,GNG Family,000211,G_gamma
+BEL,GPIT Complex,000189,GPIT
+BEL,GPX Family,000190,GPX
+BEL,GRIA Family,000191,GRIA
+BEL,GRK Family,000192,GRK
+BEL,GRM Family,000193,GRM
+BEL,GSK3 Family,000194,GSK3
+BEL,GST Family,000195,GST
+BEL,GTF2E Complex,000196,GTF2E
+BEL,GTF2F Complex,000197,GTF2F
+BEL,GUCY Family,000205,GUCY
+BEL,GYS Family,000206,GYS
+BEL,HDAC Class I Family,000221,HDAC_I
+BEL,HDAC Class II Family,000222,HDAC_II
+BEL,HDAC Family,000220,HDAC
+BEL,HDL Complex,000225,HDL
+BEL,Hedgehog Family,000226,Hedgehog
+BEL,Hemoglobin Complex,000227,Hemoglobin
+BEL,HES Family,000228,HES
+BEL,Histone Family,000233,Histone
+BEL,Histone H1 Family,000234,Histone_H1
+BEL,Histone H2A Family,000235,Histone_H2A
+BEL,Histone H2B Family,000236,Histone_H2B
+BEL,Histone H3 Family,000237,Histone_H3
+BEL,Histone H4 Family,000238,Histone_H4
+BEL,HLA-DR Family,000239,HLA_DR
+BEL,HMOX Family,000240,HMOX
+BEL,HSP90 Family,000241,HSP90
+BEL,HSPA Family,000244,HSPA
+BEL,HSPB Family,000245,HSPB
+BEL,Ib-V-IX Complex,000188,GPIb_IX_V
+BEL,IFNA Family,000246,IFNA
+BEL,IGFBP Family,000248,IGFBP
+BEL,IkappaB Kinase Complex,000250,IKK_complex
+BEL,IkappaB Kinase Family,000251,IKK_family
+BEL,IL1 Family,000252,IL1
+BEL,INS Family,000259,INS
+BEL,INSR Family,000260,INSR
+BEL,Interferon Gamma Receptor Complex,000263,Interferon_gamma_receptor
+BEL,IRS Family,000264,IRS
+BEL,IRX Family,000265,IRX
+BEL,JAK Family,000266,JAK
+BEL,Kinetochore Complex,000270,Kinetochore
+BEL,KLK Family,000271,KLK
+BEL,Laminin 1 Complex,000273,Laminin_111
+BEL,Laminin 5 Complex,000274,Laminin_332
+BEL,LDH Family,000275,LDH
+BEL,Luteinizing Hormone Complex,000276,LH
+BEL,MAF Family,000279,MAF
+BEL,MAPK Erk1/2 Family,000161,ERK
+BEL,MAPK Erk1/3 Family,000161,ERK
+BEL,MAPK JNK Family,000267,JNK
+BEL,MAPK p38 Family,000326,p38
+BEL,MEF2 Family,000285,MEF2
+BEL,MEK1/2 Family,000286,MEK
+BEL,Membrane Attack Complex,000278,MAC
+BEL,MMP Family,000291,MMP
+BEL,MYH Family,000295,MYH
+BEL,MYL Alkali Family,000297,MYL_alkali
+BEL,MYL Family,000296,MYL
+BEL,MYL Regulatory Family,000298,MYL_regulatory
+BEL,MYL Slow Family,000299,MYL_slow
+BEL,MYST Family,000300,MYST
+BEL,Na/K Exchanging ATPase Complex,000303,Na_K_ATPase
+BEL,NADH Dehydrogenase Complex,000301,NADH_dehydrogenase
+BEL,NADPH Oxidase Complex,000302,NADPH_oxidase
+BEL,NCOR Family,000306,NCOR
+BEL,NDRG Family,000307,NDRG
+BEL,NFAT Family,000309,NFAT
+BEL,Nfkb Complex,000311,NFkappaB
+BEL,Nfy Complex,000314,NFY
+BEL,NKD Family,000315,NKD
+BEL,NOS Family,000316,NOS
+BEL,NOTCH Family,000317,Notch
+BEL,NRG1/2 Family,000319,NRG_1_2
+BEL,NRG3/4 Family,000320,NRG_3_4
+BEL,NTRK Family,000321,NTRK
+BEL,p160/SRC Family,000305,NCOA
+BEL,P2RX Family,000324,P2RX
+BEL,P2RY Family,000325,P2RY
+BEL,p85/p110 PI3Kinase Complex,000358,PI3K
+BEL,PAK Family,000330,PAK
+BEL,PARV Family,000332,PARV
+BEL,PBX Family,000334,PBX
+BEL,PDE Family,000335,PDE
+BEL,PDE1 Family,000336,PDE1
+BEL,PDE3 Family,000337,PDE3
+BEL,PDE4 Family,000338,PDE4
+BEL,PDE6 Family,000339,PDE6
+BEL,PDGF Family,000342,PDGF
+BEL,PDGFR Family,000343,PDGFR
+BEL,PDK Family,000353,PDK
+BEL,PFN Family,000355,PFN
+BEL,Phosphorylase B Kinase Complex,000356,PhK
+BEL,PIK3C Class IA Family,000359,PI3K_p110
+BEL,PIK3R Class IA Family,000361,PIK3R_I
+BEL,PKI Family,000365,PKI
+BEL,PLA2 Family,000366,PLA2
+BEL,PLA2G2 Family,000367,PLA2G2
+BEL,PLC Family,000369,PLC
+BEL,PLCB Family,000370,PLCB
+BEL,PLCG Family,000372,PLCG
+BEL,PLD Family,000373,PLD
+BEL,PPAP2 Family,000374,PPAP2
+BEL,PPAR Family,000375,PPAR
+BEL,PPP1C Family,000377,PPP1C
+BEL,PPP1R Family,000378,PPP1R
+BEL,PPP2C Family,000380,PPP2C
+BEL,PPP2R Subunit A Family,000381,PPP2R_A
+BEL,PPP2R Subunit B Family,000382,PPP2R_B
+BEL,PPP3 Family,000383,PPP3
+BEL,PPP3C Family,000384,PPP3C
+BEL,PPP3R Family,000385,PPP3R
+BEL,PRC1 Maintenance Complex,000386,PRC1_complex
+BEL,PRC2 Initiation Complex,000387,PRC2_complex
+BEL,PRDX Family,000388,PRDX
+BEL,PRKA Family,000389,PRKAC
+BEL,PRKAA Family,000044,AMPK_alpha
+BEL,PRKAB Family,000045,AMPK_beta
+BEL,PRKAG Family,000046,AMPK_gamma
+BEL,PRKAR Family,000390,PRKAR
+BEL,PRKC Family,000364,PKC
+BEL,PRKG Family,000391,PRKG
+BEL,Propionyl CoA Carboxylase Complex,000392,Propionyl_CoA_carboxylase
+BEL,Proteasome Complex,000394,Proteasome
+BEL,Proton Transporting ATP Synthase Complex,000060,ATP_synthase
+BEL,PTGER Family,000395,PTGER
+BEL,Pyruvate Dehydrogenase Complex,000352,PDH
+BEL,RAB Family,000397,RAB
+BEL,RAC Family,000398,RAC
+BEL,RAF Family,000399,RAF
+BEL,RAR Family,000403,RAR
+BEL,RAS Family,000404,RAS
+BEL,Respiratory Chain Complex II,000502,ETC_complex_II
+BEL,Respiratory Chain Complex III,000503,ETC_complex_III
+BEL,RFC Complex,000411,RFC
+BEL,RFX Family,000412,RFX
+BEL,RHO Family,000414,RHO
+BEL,RNApo I Complex,000416,RNApo_I
+BEL,RNApo II Complex,000417,RNApo_II
+BEL,ROCK Family,000419,ROCK
+BEL,ROR Family,000420,ROR
+BEL,RPS6KA Family,000329,P90RSK
+BEL,RPS6KB Family,000328,P70S6K
+BEL,RXR Family,000424,RXR
+BEL,S100A Family,000426,S100A
+BEL,S1PR Family,000427,S1PR
+BEL,SAA Family,000428,SAA
+BEL,SCD Family,000429,SCD
+BEL,SERPINB Family,000431,SERPINB
+BEL,SLC2A Family,000434,SLC2A
+BEL,SMAD Family,000441,SMAD
+BEL,SMC1 Family,000444,SMC1
+BEL,SNAI Family,000446,SNAI
+BEL,SOS Family,000448,SOS
+BEL,SRC Family,000451,SRC
+BEL,SREBF Family,000452,SREBF
+BEL,STAT Family,000453,STAT
+BEL,STAT5 Family,000454,STAT5
+BEL,Sulfonylurea Receptor Family,000456,Sulfonylurea_receptor
+BEL,SWI/SNF Complex,000457,SWI_SNF
+BEL,TAP Family,000459,TAP
+BEL,TCF/LEF Family,000460,TCF_LEF
+BEL,TFAP2 Family,000463,TFAP2
+BEL,TFDP Family,000464,TFDP
+BEL,TGFB Family,000465,TGFB
+BEL,THBS Family,000467,THBS
+BEL,THR Family,000468,THR
+BEL,Thrombin Antithrombin Complex,000469,Thrombin_antithrombin
+BEL,TIF IB Complex,000471,TIF_IB
+BEL,TN Family,000473,TN
+BEL,TNFRSF Family,000475,TNFRSF
+BEL,TOP2 Family,000476,TOP2
+BEL,TORC2 Complex,000294,mTORC2
+BEL,Tryptase Family,000481,Tryptase
+BEL,TUBA Family,000483,TUBA
+BEL,TUBB Family,000484,TUBB
+BEL,TXN Family,000487,TXN
+BEL,TXNRD Family,000488,TXNRD
+BEL,UBE2 Family,000489,UBE2
+BEL,VAV Family,000494,VAV
+BEL,VEGF Family,000495,VEGF
+BEL,VEGFR Family,000496,VEGFR
+BEL,WNT Family,000497,Wnt
+COMPLEXPORTAL,CPX-560,000503,ETC_complex_III
+COMPLEXPORTAL,CPX-561,000502,ETC_complex_II
+COMPLEXPORTAL,CPX-577,000501,ETC_complex_I
+ECCODE,1.1.1.1,000018,ADH
+ECCODE,1.10.2.2,000503,ETC_complex_III
+ECCODE,1.11.1.15,000388,PRDX
+ECCODE,1.11.1.9,000190,GPX
+ECCODE,1.14.19.1,000429,SCD
+ECCODE,1.14.99.3,000240,HMOX
+ECCODE,1.2.1.3,000024,ALDH
+ECCODE,1.2.4.1,000353,PDK
+ECCODE,1.3.5.1,000502,ETC_complex_II
+ECCODE,1.3.8.7,000004,ACAD
+ECCODE,1.6.5.3,000501,ETC_complex_I
+ECCODE,1.6.5.3,000301,NADH_dehydrogenase
+ECCODE,1.9.3.1,000113,COX
+ECCODE,1.9.3.1,000504,ETC_complex_IV
+ECCODE,2.3.2.23,000489,UBE2
+ECCODE,2.5.1.58,000172,FNT
+ECCODE,2.7.1.107,000140,DGK
+ECCODE,2.7.11.11,000363,PKA
+ECCODE,2.7.11.12,000391,PRKG
+ECCODE,2.7.11.13,000364,PKC
+ECCODE,2.7.11.16,000192,GRK
+ECCODE,2.7.11.17,000076,CAMK
+ECCODE,2.7.11.19,000356,PhK
+ECCODE,2.7.11.22,000092,CDK
+ECCODE,2.7.11.24,000283,MAPK
+ECCODE,2.7.11.25,000282,MAP3K
+ECCODE,2.7.11.31,000031,AMPK
+ECCODE,2.7.12.2,000283,MAPK
+ECCODE,3.1.1.1,000080,Carboxylesterase
+ECCODE,3.1.1.4,000366,PLA2
+ECCODE,3.1.4.-,000335,PDE
+ECCODE,3.1.4.4,000373,PLD
+ECCODE,3.4.21.35,000271,KLK
+ECCODE,3.4.21.59,000481,Tryptase
+ECCODE,3.4.25.1,000394,Proteasome
+ECCODE,3.5.1.98,000220,HDAC
+ECCODE,3.6.3.14,000505,ETC_complex_V
+ECCODE,3.6.3.9,000303,Na_K_ATPase
+ECCODE,3.6.5.-,000204,GTPase
+ECCODE,4.1.2.13,000025,ALDO
+ECCODE,4.6.1.2,000205,GUCY
+ECCODE,6.4.1.2,000005,ACC
+ECCODE,6.4.1.3,000392,Propionyl_CoA_carboxylase
+GFAM,1199,000269,Kainate_family
+GFAM,1582,000308,Neurexins
+GO,GO:0000145,000164,EXOC
+GO,GO:0000502,000394,Proteasome
+GO,GO:0000776,000270,Kinetochore
+GO,GO:0000930,000485,TUBG
+GO,GO:0004117,000336,PDE1
+GO,GO:0004198,000079,CAPN
+GO,GO:0004199,000081,Caspase
+GO,GO:0004886,000424,RXR
+GO,GO:0004890,000179,GABR
+GO,GO:0004931,000324,P2RX
+GO,GO:0004936,000019,ADRA
+GO,GO:0004937,000019,ADRA
+GO,GO:0004938,000020,ADRA2
+GO,GO:0004952,000143,DRD
+GO,GO:0005007,000168,FGFR
+GO,GO:0005035,000137,Death_receptor
+GO,GO:0005094,000415,RhoGDI
+GO,GO:0005096,000182,GAP
+GO,GO:0005154,000150,EGFR_ligand
+GO,GO:0005161,000342,PDGF
+GO,GO:0005162,000167,FGF
+GO,GO:0005172,000496,VEGFR
+GO,GO:0005355,000434,SLC2A
+GO,GO:0005577,000169,Fibrinogen
+GO,GO:0005579,000278,MAC
+GO,GO:0005584,000109,COL1
+GO,GO:0005587,000110,COL4
+GO,GO:0005588,000111,COL5
+GO,GO:0005610,000274,Laminin_332
+GO,GO:0005663,000411,RFC
+GO,GO:0005665,000417,RNApo_II
+GO,GO:0005673,000196,GTF2E
+GO,GO:0005674,000197,GTF2F
+GO,GO:0005680,000050,APC_C
+GO,GO:0005736,000416,RNApo_I
+GO,GO:0005747,000501,ETC_complex_I
+GO,GO:0005749,000502,ETC_complex_II
+GO,GO:0005750,000503,ETC_complex_III
+GO,GO:0005751,000504,ETC_complex_IV
+GO,GO:0005753,000505,ETC_complex_V
+GO,GO:0005761,000288,Mitochondrial_Ribosome
+GO,GO:0005762,000290,MRPL
+GO,GO:0005763,000289,MRPS
+GO,GO:0005832,000085,CCT_complex
+GO,GO:0005861,000477,Troponin
+GO,GO:0005868,000135,Cytoplasmic_dynein
+GO,GO:0005884,000009,Actin
+GO,GO:0005956,000104,CK2
+GO,GO:0008190,000154,EIF4EBP
+GO,GO:0008278,000108,Cohesin
+GO,GO:0008279,000108,Cohesin
+GO,GO:0008281,000456,Sulfonylurea_receptor
+GO,GO:0008433,000186,GEF
+GO,GO:0008599,000376,PPP1
+GO,GO:0016010,000139,DGC
+GO,GO:0016190,000105,Clathrin
+GO,GO:0016904,000103,CHRN
+GO,GO:0016914,000175,FSH
+GO,GO:0019787,000489,UBE2
+GO,GO:0030122,000015,Adaptor_protein_II
+GO,GO:0031518,000084,CBF3
+GO,GO:0031931,000293,mTORC1
+GO,GO:0031941,000178,F_actin
+GO,GO:0032281,000191,GRIA
+GO,GO:0034364,000225,HDL
+GO,GO:0034666,000261,Integrins
+GO,GO:0034683,000261,Integrins
+GO,GO:0034687,000261,Integrins
+GO,GO:0035098,000387,PRC2_complex
+GO,GO:0035102,000386,PRC1_complex
+GO,GO:0038036,000427,S1PR
+GO,GO:0042555,000284,MCM
+GO,GO:0042825,000459,TAP
+GO,GO:0043509,000011,Activin_A
+GO,GO:0043511,000256,Inhibin
+GO,GO:0043625,000141,DNA_polymerase_delta
+GO,GO:0045275,000503,ETC_complex_III
+GO,GO:0048180,000010,Activin
+GO,GO:0070652,000061,Augmin
+GO,GO:0070765,000181,Gamma_secretase
+GO,GO:1990779,000188,GPIb_IX_V
+HGNC_GROUP,1149,000499,ETC_complex_I_core
+HGNC_GROUP,1150,000500,ETC_complex_I_supernumerary
+HGNC_GROUP,581,000061,Augmin
+HGNC_GROUP,640,000501,ETC_complex_I
+HGNC_GROUP,641,000502,ETC_complex_II
+HGNC_GROUP,642,000503,ETC_complex_III
+HGNC_GROUP,643,000504,ETC_complex_IV
+HGNC_GROUP,644,000505,ETC_complex_V
+IP,IPR000074,000052,Apolipoprotein
+IP,IPR000096,000428,SAA
+IP,IPR000162,000193,GRM
+IP,IPR000164,000237,Histone_H3
+IP,IPR000239,000192,GRK
+IP,IPR000308,000323,p14_3_3
+IP,IPR000320,000226,Hedgehog
+IP,IPR000381,000013,Activin_B
+IP,IPR000388,000456,Sulfonylurea_receptor
+IP,IPR000406,000415,RhoGDI
+IP,IPR000451,000311,NFkappaB
+IP,IPR000454,000059,ATP5G
+IP,IPR000469,000207,G_12
+IP,IPR000469,000208,G_12_alpha
+IP,IPR000491,000011,Activin_A
+IP,IPR000654,000215,G_q
+IP,IPR000654,000216,G_q_alpha
+IP,IPR000741,000025,ALDO
+IP,IPR000751,000091,CDC25
+IP,IPR000756,000140,DGK
+IP,IPR000889,000190,GPX
+IP,IPR000929,000143,DRD
+IP,IPR000941,000157,ENO
+IP,IPR000995,000102,CHRM
+IP,IPR000997,000101,Cholinesterase
+IP,IPR001090,000158,Ephrin_receptor
+IP,IPR001132,000441,SMAD
+IP,IPR001154,000476,TOP2
+IP,IPR001208,000284,MCM
+IP,IPR001217,000453,STAT
+IP,IPR001241,000476,TOP2
+IP,IPR001349,000115,COX6A
+IP,IPR001370,000066,BIRC
+IP,IPR001408,000212,G_i
+IP,IPR001408,000213,G_i_alpha
+IP,IPR001426,000158,Ephrin_receptor
+IP,IPR001429,000324,P2RX
+IP,IPR001442,000110,COL4
+IP,IPR001522,000429,SCD
+IP,IPR001612,000083,CAV
+IP,IPR001657,000226,Hedgehog
+IP,IPR001767,000226,Hedgehog
+IP,IPR001770,000211,G_gamma
+IP,IPR001928,000149,EDN
+IP,IPR001951,000238,Histone_H4
+IP,IPR002051,000240,HMOX
+IP,IPR002112,000268,JUN_family
+IP,IPR002117,000327,p53_family
+IP,IPR002138,000081,Caspase
+IP,IPR002194,000085,CCT_complex
+IP,IPR002205,000476,TOP2
+IP,IPR002209,000167,FGF
+IP,IPR002374,000391,PRKG
+IP,IPR002453,000484,TUBB
+IP,IPR002454,000485,TUBG
+IP,IPR002655,000007,ACOX
+IP,IPR002717,000300,MYST
+IP,IPR003000,000223,HDAC_III
+IP,IPR003074,000375,PPAR
+IP,IPR003084,000220,HDAC
+IP,IPR003084,000221,HDAC_I
+IP,IPR003113,000359,PI3K_p110
+IP,IPR003175,000095,CDKN1
+IP,IPR003205,000119,COX8
+IP,IPR003367,000467,THBS
+IP,IPR003502,000252,IL1
+IP,IPR003586,000226,Hedgehog
+IP,IPR003587,000226,Hedgehog
+IP,IPR004000,000009,Actin
+IP,IPR004030,000316,NOS
+IP,IPR004061,000427,S1PR
+IP,IPR004142,000307,NDRG
+IP,IPR004171,000365,PKI
+IP,IPR004203,000114,COX4
+IP,IPR004241,000280,MAP1LC3
+IP,IPR004766,000333,Patched
+IP,IPR004826,000279,MAF
+IP,IPR004979,000463,TFAP2
+IP,IPR005455,000355,PFN
+IP,IPR005542,000334,PBX
+IP,IPR005643,000268,JUN_family
+IP,IPR005782,000430,SERCA
+IP,IPR005817,000497,Wnt
+IP,IPR006019,000432,SHC
+IP,IPR006338,000488,TXNRD
+IP,IPR006828,000045,AMPK_beta
+IP,IPR008297,000317,Notch
+IP,IPR008349,000161,ERK
+IP,IPR008351,000267,JNK
+IP,IPR008352,000326,p38
+IP,IPR008366,000309,NFAT
+IP,IPR008433,000118,COX7B
+IP,IPR008606,000154,EIF4EBP
+IP,IPR008631,000206,GYS
+IP,IPR008859,000467,THBS
+IP,IPR009045,000226,Hedgehog
+IP,IPR009123,000138,Desmoglein
+IP,IPR010011,000305,NCOA
+IP,IPR010660,000317,Notch
+IP,IPR010991,000327,p53_family
+IP,IPR011039,000197,GTF2F
+IP,IPR011615,000327,p53_family
+IP,IPR011656,000317,Notch
+IP,IPR012144,000316,NOS
+IP,IPR012198,000390,PRKAR
+IP,IPR012233,000364,PKC
+IP,IPR012290,000169,Fibrinogen
+IP,IPR012345,000453,STAT
+IP,IPR012542,000476,TOP2
+IP,IPR013019,000441,SMAD
+IP,IPR013288,000114,COX4
+IP,IPR013506,000476,TOP2
+IP,IPR013537,000005,ACC
+IP,IPR013543,000077,CAMK2_complex
+IP,IPR013543,000078,CAMK2_family
+IP,IPR013558,000460,TCF_LEF
+IP,IPR013706,000336,PDE1
+IP,IPR013757,000476,TOP2
+IP,IPR013758,000476,TOP2
+IP,IPR013759,000476,TOP2
+IP,IPR013760,000476,TOP2
+IP,IPR013790,000441,SMAD
+IP,IPR013799,000453,STAT
+IP,IPR013800,000453,STAT
+IP,IPR013801,000453,STAT
+IP,IPR013854,000463,TFAP2
+IP,IPR013871,000121,CRISP
+IP,IPR014788,000101,Cholinesterase
+IP,IPR014920,000305,NCOA
+IP,IPR014935,000305,NCOA
+IP,IPR014936,000062,AXIN
+IP,IPR015008,000419,ROCK
+IP,IPR015015,000003,ABL_family
+IP,IPR015451,000132,Cyclin_D
+IP,IPR015583,000349,PDGF_BB
+IP,IPR015588,000247,IFNB
+IP,IPR015615,000465,TGFB
+IP,IPR015633,000147,E2F
+IP,IPR015679,000373,PLD
+IP,IPR015876,000429,SCD
+IP,IPR015988,000453,STAT
+IP,IPR016053,000240,HMOX
+IP,IPR016072,000084,CBF3
+IP,IPR016084,000240,HMOX
+IP,IPR016239,000329,P90RSK
+IP,IPR016245,000160,ERBB
+IP,IPR016246,000260,INSR
+IP,IPR016247,000420,ROR
+IP,IPR016248,000168,FGFR
+IP,IPR016251,000266,JAK
+IP,IPR016257,000158,Ephrin_receptor
+IP,IPR016279,000372,PLCG
+IP,IPR016280,000370,PLCB
+IP,IPR016311,000163,ETS
+IP,IPR016319,000465,TGFB
+IP,IPR016346,000210,G_beta
+IP,IPR016897,000084,CBF3
+IP,IPR017104,000049,AP2A
+IP,IPR017348,000362,PIM
+IP,IPR017426,000305,NCOA
+IP,IPR017897,000467,THBS
+IP,IPR017904,000107,Cofilin
+IP,IPR018161,000497,Wnt
+IP,IPR018207,000240,HMOX
+IP,IPR018361,000083,CAV
+IP,IPR018507,000115,COX6A
+IP,IPR018522,000476,TOP2
+IP,IPR019764,000149,EDN
+IP,IPR020475,000149,EDN
+IP,IPR020537,000059,ATP5G
+IP,IPR020684,000419,ROCK
+IP,IPR020777,000321,NTRK
+IP,IPR020810,000157,ENO
+IP,IPR020811,000157,ENO
+IP,IPR022684,000079,CAPN
+IP,IPR023272,000118,COX7B
+IP,IPR023337,000449,SPRED
+IP,IPR023409,000323,p14_3_3
+IP,IPR023410,000323,p14_3_3
+IP,IPR024940,000460,TCF_LEF
+IP,IPR024946,000476,TOP2
+IP,IPR025561,000272,KSR
+IP,IPR026590,000223,HDAC_III
+IP,IPR027288,000346,PDGFR_BB
+IP,IPR027290,000344,PDGFR_AA
+IP,IPR027309,000324,P2RX
+IP,IPR027705,000170,FLOT
+IP,IPR027707,000480,Troponin_T
+IP,IPR027936,000158,Ephrin_receptor
+IP,IPR028412,000400,RAL
+IP,IPR028433,000332,PARV
+IP,IPR028858,000133,Cyclin_E
+IP,IPR028974,000467,THBS
+IP,IPR028992,000226,Hedgehog
+IP,IPR029760,000190,GPX
+IP,IPR029768,000025,ALDO
+IP,IPR030492,000311,NFkappaB
+IP,IPR031327,000284,MCM
+IP,IPR031635,000321,NTRK
+IP,IPR031660,000476,TOP2
+IP,IPR031675,000377,PPP1C
+IP,IPR031905,000170,FLOT
+IP,IPR032067,000174,FOXO
+IP,IPR032101,000062,AXIN
+IP,IPR032270,000044,AMPK_alpha
+IP,IPR032640,000045,AMPK_beta
+IP,IPR033139,000081,Caspase
+IP,IPR033614,000410,RASSF
+IP,IPR033896,000285,MEF2
+IP,IPR033923,000330,PAK
+IP,IPR033926,000311,NFkappaB
+IP,IPR034117,000121,CRISP
+IP,IPR034157,000476,TOP2
+IP,IPR035014,000391,PRKG
+IP,IPR035023,000372,PLCG
+IP,IPR035024,000372,PLCG
+MEDSCAN,urn:agi-aopfc:0000094,000120,CREB
+MEDSCAN,urn:agi-aopfc:0000099,000147,E2F
+MEDSCAN,urn:agi-aopfc:0000105,000184,GATA
+MEDSCAN,urn:agi-aopfc:0000142,000279,MAF
+MEDSCAN,urn:agi-aopfc:0000143,000285,MEF2
+MEDSCAN,urn:agi-aopfc:0000150,000310,NFE
+MEDSCAN,urn:agi-aopfc:0000156,000311,NFkappaB
+MEDSCAN,urn:agi-aopfc:0000157,000412,RFX
+MEDSCAN,urn:agi-aopfc:0000159,000441,SMAD
+MEDSCAN,urn:agi-aopfc:0000163,000453,STAT
+MEDSCAN,urn:agi-aopfc:0000197,000177,FZD
+MEDSCAN,urn:agi-aopfc:0000252,000136,DDR
+MEDSCAN,urn:agi-aopfc:0000264,000260,INSR
+MEDSCAN,urn:agi-aopfc:0000278,000321,NTRK
+MEDSCAN,urn:agi-aopfc:0000279,000317,Notch
+MEDSCAN,urn:agi-aopfc:0000281,000333,Patched
+MEDSCAN,urn:agi-aopfc:0000286,000420,ROR
+MEDSCAN,urn:agi-aopfc:0000294,000466,TGFBR
+MEDSCAN,urn:agi-aopfc:0000295,000475,TNFRSF
+MEDSCAN,urn:agi-aopfc:0000296,000472,TLR
+MEDSCAN,urn:agi-aopfc:0000311,000187,GPCR
+MEDSCAN,urn:agi-aopfc:0000391,000099,Chemokine
+MEDSCAN,urn:agi-aopfc:0000423,000465,TGFB
+MEDSCAN,urn:agi-aopfc:0000426,000497,Wnt
+MEDSCAN,urn:agi-aopfc:0000434,000194,GSK3
+MEDSCAN,urn:agi-aopfc:0000439,000023,AKT
+MEDSCAN,urn:agi-aopfc:0000447,000358,PI3K
+MEDSCAN,urn:agi-aopfc:0000452,000075,CALM
+MEDSCAN,urn:agi-aopfc:0000455,000366,PLA2
+MEDSCAN,urn:agi-aopfc:0000458,000161,ERK
+MEDSCAN,urn:agi-aopfc:0000462,000286,MEK
+MEDSCAN,urn:agi-aopfc:0000464,000266,JAK
+MEDSCAN,urn:agi-aopfc:0000465,000404,RAS
+MEDSCAN,urn:agi-aopfc:0000468,000330,PAK
+MEDSCAN,urn:agi-aopfc:0000473,000267,JNK
+MEDSCAN,urn:agi-aopfc:0000477,000326,p38
+MEDSCAN,urn:agi-aopfc:0000479,000302,NADPH_oxidase
+MEDSCAN,urn:agi-aopfc:0000494,000316,NOS
+MEDSCAN,urn:agi-aopfc:0000499,000414,RHO
+MEDSCAN,urn:agi-aopfc:0000504,000494,VAV
+MEDSCAN,urn:agi-aopfc:0000509,000451,SRC
+MEDSCAN,urn:agi-aopfc:0000551,000091,CDC25
+MEDSCAN,urn:agi-aopfc:0000567,000003,ABL_family
+MEDSCAN,urn:agi-aopfc:0000571,000050,APC_C
+MEDSCAN,urn:agi-aopfc:0000585,000264,IRS
+MEDSCAN,urn:agi-aopfc:0000586,000248,IGFBP
+MEDSCAN,urn:agi-aopfc:0000587,000226,Hedgehog
+MEDSCAN,urn:agi-aopfc:0000615,000252,IL1
+MEDSCAN,urn:agi-aopfc:0000704,000339,PDE6
+MEDSCAN,urn:agi-complex:CaM%20kinase%20II,000077,CAMK2_complex
+MEDSCAN,urn:agi-complex:CD3%20complex,000087,CD3
+MEDSCAN,urn:agi-complex:CD8,000090,CD8
+MEDSCAN,urn:agi-complex:HIF-1,000230,HIF1
+MEDSCAN,urn:agi-complex:IFNGR,000263,Interferon_gamma_receptor
+MEDSCAN,urn:agi-complex:IKK%20complex,000250,IKK_complex
+MEDSCAN,urn:agi-complex:IL12,000253,IL12
+MEDSCAN,urn:agi-complex:inhibin%20A,000257,Inhibin_A
+MEDSCAN,urn:agi-complex:Luteinizing%20hormone,000276,LH
+MEDSCAN,urn:agi-complex:MAC-1%20(integrin),000261,Integrins
+MEDSCAN,urn:agi-complex:NF-E2,000310,NFE
+MEDSCAN,urn:agi-complex:platelet%20derived%20growth%20factor%20AA,000347,PDGF_AA
+MEDSCAN,urn:agi-complex:platelet%20derived%20growth%20factor%20AB,000348,PDGF_AB
+MEDSCAN,urn:agi-complex:platelet%20derived%20growth%20factor%20BB,000349,PDGF_BB
+MEDSCAN,urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267,000177,FZD
+MEDSCAN,urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168,000294,mTORC2
+MEDSCAN,urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121,000233,Histone
+MEDSCAN,urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa,000358,PI3K
+MEDSCAN,urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b,000387,PRC2_complex
+MEDSCAN,urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15,000453,STAT
+MEDSCAN,urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388,000147,E2F
+MEDSCAN,urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85,000230,HIF1
+MEDSCAN,urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee,000092,CDK
+MEDSCAN,urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd,000490,Ubiquitin
+MEDSCAN,urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28,000441,SMAD
+MEDSCAN,urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e,000411,RFC
+MEDSCAN,urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da,000187,GPCR
+MEDSCAN,urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b,000220,HDAC
+MEDSCAN,urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896,000074,Cadherin
+MEDSCAN,urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa,000311,NFkappaB
+MEDSCAN,urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75,000268,JUN_family
+MEDSCAN,urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802,000486,Tubulin
+MEDSCAN,urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6,000466,TGFBR
+MEDSCAN,urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd,000386,PRC1_complex
+MEDSCAN,urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422,000424,RXR
+MEDSCAN,urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9,000127,CUL
+MEDSCAN,urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61,000085,CCT_complex
+MEDSCAN,urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c,000376,PPP1
+MEDSCAN,urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4,000417,RNApo_II
+MEDSCAN,urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35,000050,APC_C
+MEDSCAN,urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086,000477,Troponin
+MEDSCAN,urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1,000284,MCM
+MEDSCAN,urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196,000204,GTPase
+MEDSCAN,urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3,000379,PPP2
+MEDSCAN,urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e,000293,mTORC1
+MEDSCAN,urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861,000457,SWI_SNF
+MEDSCAN,urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11,000075,CALM
+MEDSCAN,urn:agi-complex:protein%20phosphatase%203,000383,PPP3
+MEDSCAN,urn:agi-complex:protein%20phosphatase%20type%201%20complex,000376,PPP1
+MEDSCAN,urn:agi-complex:protein%20phosphatase%20type%202A%20complex,000379,PPP2
+MEDSCAN,urn:agi-complex:SMAD2%2f3,000443,SMAD2_3
+MEDSCAN,urn:agi-protfc:14-3-3,000323,p14_3_3
+MEDSCAN,urn:agi-protfc:actins,000009,Actin
+MEDSCAN,urn:agi-protfc:AMPK,000031,AMPK
+MEDSCAN,urn:agi-protfc:apolipoprotein,000052,Apolipoprotein
+MEDSCAN,urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor,000069,BMP_receptor_type_I
+MEDSCAN,urn:agi-protfc:cadherin,000074,Cadherin
+MEDSCAN,urn:agi-protfc:casein%20kinase%20I,000124,CSNK1
+MEDSCAN,urn:agi-protfc:caveolin,000083,CAV
+MEDSCAN,urn:agi-protfc:checkpoint%20kinase,000098,CHEK
+MEDSCAN,urn:agi-protfc:chromatin%20remodeling%20complex,000457,SWI_SNF
+MEDSCAN,urn:agi-protfc:class%20c%20orphan%20receptor,000187,GPCR
+MEDSCAN,urn:agi-protfc:cullin,000127,CUL
+MEDSCAN,urn:agi-protfc:cyclin,000130,Cyclin
+MEDSCAN,urn:agi-protfc:cyclophilins,000134,Cyclophilin
+MEDSCAN,urn:agi-protfc:cytosolic%20phospholipase%20a2,000366,PLA2
+MEDSCAN,urn:agi-protfc:desmoglein,000138,Desmoglein
+MEDSCAN,urn:agi-protfc:endothelin,000149,EDN
+MEDSCAN,urn:agi-protfc:F-actin-binding%20protein,000178,F_actin
+MEDSCAN,urn:agi-protfc:flotillin,000170,FLOT
+MEDSCAN,urn:agi-protfc:hemoglobin,000227,Hemoglobin
+MEDSCAN,urn:agi-protfc:histone%20H1,000234,Histone_H1
+MEDSCAN,urn:agi-protfc:histone%20H2A,000235,Histone_H2A
+MEDSCAN,urn:agi-protfc:histone%20H2B,000236,Histone_H2B
+MEDSCAN,urn:agi-protfc:histone%20H3,000237,Histone_H3
+MEDSCAN,urn:agi-protfc:histone%20H4,000238,Histone_H4
+MEDSCAN,urn:agi-protfc:histone,000233,Histone
+MEDSCAN,urn:agi-protfc:interferon,000262,Interferon
+MEDSCAN,urn:agi-protfc:kallikrein,000271,KLK
+MEDSCAN,urn:agi-protfc:mglur,000193,GRM
+MEDSCAN,urn:agi-protfc:myosin%20heavy%20chain,000295,MYH
+MEDSCAN,urn:agi-protfc:myosin%20light%20chain,000296,MYL
+MEDSCAN,urn:agi-protfc:neuregulin%20family,000318,NRG
+MEDSCAN,urn:agi-protfc:p2y%20receptor,000325,P2RY
+MEDSCAN,urn:agi-protfc:p70rsk,000328,P70S6K
+MEDSCAN,urn:agi-protfc:p90rsk,000329,P90RSK
+MEDSCAN,urn:agi-protfc:PDE4%20subfamily,000338,PDE4
+MEDSCAN,urn:agi-protfc:phosphodiesterase%20III,000337,PDE3
+MEDSCAN,urn:agi-protfc:ppar,000375,PPAR
+MEDSCAN,urn:agi-protfc:profilin,000355,PFN
+MEDSCAN,urn:agi-protfc:rab,000397,RAB
+MEDSCAN,urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase,000430,SERCA
+MEDSCAN,urn:agi-protfc:shc%20protein,000432,SHC
+MEDSCAN,urn:agi-protfc:STAT5%20protein,000454,STAT5
+MEDSCAN,urn:agi-protfc:sterol%20regulatory%20element%20binding%20protein,000452,SREBF
+MEDSCAN,urn:agi-protfc:SWI%2fSNF%20family,000457,SWI_SNF
+MEDSCAN,urn:agi-protfc:thioredoxin,000487,TXN
+MEDSCAN,urn:agi-protfc:thrombospondins,000467,THBS
+MEDSCAN,urn:agi-protfc:tubulin,000486,Tubulin
+MEDSCAN,urn:agi-protfc:ubiquitin,000490,Ubiquitin
+MESH,C072194,000349,PDGF_BB
+MESH,D000199,000009,Actin
+MESH,D003576,000504,ETC_complex_IV
+MESH,D006657,000233,Histone
+MESH,D010749,000357,Phosphatase
+MESH,D011493,000364,PKC
+MESH,D011948,000461,TCR
+MESH,D014450,000503,ETC_complex_III
+MESH,D016695,000198,Glycosyltransferase
+MESH,D018808,000048,AP1
+MESH,D018844,000092,CDK
+MESH,D020169,000081,Caspase
+MESH,D025261,000505,ETC_complex_V
+MESH,D042963,000502,ETC_complex_II
+MESH,D042967,000501,ETC_complex_I
+MESH,D046988,000394,Proteasome
+NCIT,C104194,000132,Cyclin_D
+NCIT,C104197,000133,Cyclin_E
+NCIT,C104199,000251,IKK_family
+NCIT,C104676,000473,TN
+NCIT,C105947,000281,MAP2K
+NCIT,C105952,000051,APOA
+NCIT,C107433,000338,PDE4
+NCIT,C107559,000104,CK2
+NCIT,C112049,000502,ETC_complex_II
+NCIT,C112051,000080,Carboxylesterase
+NCIT,C113839,000229,HIF
+NCIT,C116019,000044,AMPK_alpha
+NCIT,C118184,000501,ETC_complex_I
+NCIT,C118481,000024,ALDH
+NCIT,C118892,000174,FOXO
+NCIT,C120030,000481,Tryptase
+NCIT,C120493,000226,Hedgehog
+NCIT,C124129,000109,COL1
+NCIT,C126114,000372,PLCG
+NCIT,C126122,000188,GPIb_IX_V
+NCIT,C129655,000484,TUBB
+NCIT,C16258,000009,Actin
+NCIT,C16264,000017,ADCY
+NCIT,C16272,000018,ADH
+NCIT,C16373,000074,Cadherin
+NCIT,C16375,000075,CALM
+NCIT,C16376,000161,ERK
+NCIT,C16376,000283,MAPK
+NCIT,C16377,000079,CAPN
+NCIT,C16448,000110,COL4
+NCIT,C16479,000363,PKA
+NCIT,C16511,000141,DNA_polymerase_delta
+NCIT,C16641,000195,GST
+NCIT,C16650,000204,GTPase
+NCIT,C16653,000205,GUCY
+NCIT,C16676,000227,Hemoglobin
+NCIT,C16682,000220,HDAC
+NCIT,C16683,000234,Histone_H1
+NCIT,C16684,000235,Histone_H2A
+NCIT,C16685,000237,Histone_H3
+NCIT,C16686,000238,Histone_H4
+NCIT,C16687,000233,Histone
+NCIT,C16692,000239,HLA_DR
+NCIT,C16748,000261,Integrins
+NCIT,C16965,000393,Protease
+NCIT,C16979,000366,PLA2
+NCIT,C16981,000357,Phosphatase
+NCIT,C17017,000364,PKC
+NCIT,C17061,000404,RAS
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+NCIT,C17078,000468,THR
+NCIT,C17219,000486,Tubulin
+NCIT,C17227,000490,Ubiquitin
+NCIT,C17270,000358,PI3K
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+NCIT,C17293,000496,VEGFR
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+NCIT,C17343,000479,Troponin_I
+NCIT,C17349,000130,Cyclin
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+NCIT,C17450,000048,AP1
+NCIT,C17458,000214,G_protein
+NCIT,C17487,000086,CD16
+NCIT,C17494,000186,GEF
+NCIT,C17532,000403,RAR
+NCIT,C17534,000424,RXR
+NCIT,C17583,000249,IKB
+NCIT,C17660,000423,RTK
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+NCIT,C18164,000291,MMP
+NCIT,C18239,000187,GPCR
+NCIT,C18308,000088,CD32
+NCIT,C18434,000476,TOP2
+NCIT,C18492,000094,CDKN
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+NCIT,C19275,000213,G_i_alpha
+NCIT,C19618,000453,STAT
+NCIT,C19836,000368,PLA2G4
+NCIT,C19866,000386,PRC1_complex
+NCIT,C20448,000342,PDGF
+NCIT,C129646,000495,VEGF
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+NCIT,C20493,000262,Interferon
+NCIT,C20495,000247,IFNB
+NCIT,C20506,000252,IL1
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+NCIT,C20591,000457,SWI_SNF
+NCIT,C2275,000219,hCG
+NCIT,C2276,000256,Inhibin
+NCIT,C2277,000257,Inhibin_A
+NCIT,C2278,000258,Inhibin_B
+NCIT,C25184,000275,LDH
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+NCIT,C26233,000192,GRK
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+NCIT,C28687,000122,CRSP
+NCIT,C38041,000480,Troponin_T
+NCIT,C38897,000087,CD3
+NCIT,C41625,000023,AKT
+NCIT,C736,000354,Pertussis_toxin
+NCIT,C94701,000031,AMPK
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+NCIT,C95947,000416,RNApo_I
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+NCIT,C96314,000293,mTORC1
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+NXP,FA:00078,000009,Actin
+NXP,FA:00093,000004,ACAD
+NXP,FA:00209,000463,TFAP2
+NXP,FA:00406,000097,CEBP
+NXP,FA:00408,000173,FOS_family
+NXP,FA:00421,000385,PPP3R
+NXP,FA:00440,000075,CALM
+NXP,FA:00489,000083,CAV
+NXP,FA:00653,000106,CNKSR
+NXP,FA:00787,000127,CUL
+NXP,FA:00803,000337,PDE3
+NXP,FA:00804,000338,PDE4
+NXP,FA:00815,000130,Cyclin
+NXP,FA:00818,000132,Cyclin_D
+NXP,FA:00819,000133,Cyclin_E
+NXP,FA:00921,000153,EIF4A
+NXP,FA:01112,000157,ENO
+NXP,FA:01121,000159,EPN
+NXP,FA:01400,000211,G_gamma
+NXP,FA:01553,000190,GPX
+NXP,FA:01669,000195,GST
+NXP,FA:01729,000226,Hedgehog
+NXP,FA:01762,000235,Histone_H2A
+NXP,FA:01764,000237,Histone_H3
+NXP,FA:01765,000238,Histone_H4
+NXP,FA:01820,000252,IL1
+NXP,FA:01869,000259,INS
+NXP,FA:02022,000275,LDH
+NXP,FA:02159,000434,SLC2A
+NXP,FA:02187,000284,MCM
+NXP,FA:02504,000316,NOS
+NXP,FA:02506,000317,Notch
+NXP,FA:02630,000324,P2RX
+NXP,FA:02632,000327,p53_family
+NXP,FA:02660,000332,PARV
+NXP,FA:02762,000156,ELA
+NXP,FA:02767,000481,Tryptase
+NXP,FA:02840,000366,PLA2
+NXP,FA:03001,000376,PPP1
+NXP,FA:03065,000364,PKC
+NXP,FA:03066,000398,RAC
+NXP,FA:03071,000031,AMPK
+NXP,FA:03072,000076,CAMK
+NXP,FA:03078,000362,PIM
+NXP,FA:03083,000124,CSNK1
+NXP,FA:03087,000194,GSK3
+NXP,FA:03091,000146,DYRK
+NXP,FA:03101,000104,CK2
+NXP,FA:03104,000251,IKK_family
+NXP,FA:03114,000399,RAF
+NXP,FA:03124,000158,Ephrin_receptor
+NXP,FA:03128,000260,INSR
+NXP,FA:03129,000266,JAK
+NXP,FA:03130,000420,ROR
+NXP,FA:03131,000451,SRC
+NXP,FA:03483,000428,SAA
+NXP,FA:03579,000431,SERPINB
+NXP,FA:03661,000397,RAB
+NXP,FA:03663,000404,RAS
+NXP,FA:03668,000414,RHO
+NXP,FA:03672,000435,SLRP
+NXP,FA:03673,000436,SLRP_1
+NXP,FA:03674,000437,SLRP_2
+NXP,FA:03675,000438,SLRP_3
+NXP,FA:03676,000439,SLRP_4
+NXP,FA:03677,000440,SLRP_5
+NXP,FA:03686,000444,SMC1
+NXP,FA:03943,000460,TCF_LEF
+NXP,FA:03964,000473,TN
+NXP,FA:03989,000465,TGFB
+NXP,FA:04000,000487,TXN
+NXP,FA:04014,000470,TIAM
+NXP,FA:04239,000486,Tubulin
+NXP,FA:04243,000474,TNF
+NXP,FA:04276,000490,Ubiquitin
+NXP,FA:04282,000489,UBE2
+NXP,FA:04686,000497,Wnt
+NXP,FA:04773,000401,RAP1
+PF,PF00012,000244,HSPA
+PF,PF00022,000009,Actin
+PF,PF00028,000074,Cadherin
+PF,PF00066,000317,Notch
+PF,PF00071,000404,RAS
+PF,PF00110,000497,Wnt
+PF,PF00143,000262,Interferon
+PF,PF00146,000301,NADH_dehydrogenase
+PF,PF00167,000167,FGF
+PF,PF00178,000163,ETS
+PF,PF00183,000241,HSP90
+PF,PF00219,000248,IGFBP
+PF,PF00229,000474,TNF
+PF,PF00235,000355,PFN
+PF,PF00244,000323,p14_3_3
+PF,PF00255,000190,GPX
+PF,PF00277,000428,SAA
+PF,PF00320,000184,GATA
+PF,PF00322,000149,EDN
+PF,PF00340,000252,IL1
+PF,PF00465,000018,ADH
+PF,PF00493,000284,MCM
+PF,PF00503,000209,G_alpha
+PF,PF00616,000407,RasGAP
+PF,PF00644,000331,PARP
+PF,PF00656,000081,Caspase
+PF,PF00864,000324,P2RX
+PF,PF00870,000327,p53_family
+PF,PF00888,000127,CUL
+PF,PF00963,000108,Cohesin
+PF,PF01146,000083,CAV
+PF,PF01442,000052,Apolipoprotein
+PF,PF01534,000177,FZD
+PF,PF01756,000007,ACOX
+PF,PF02046,000115,COX6A
+PF,PF02158,000318,NRG
+PF,PF02174,000264,IRS
+PF,PF02234,000094,CDKN
+PF,PF02238,000117,COX7A
+PF,PF02285,000119,COX8
+PF,PF02297,000116,COX6B
+PF,PF02377,000145,DVL
+PF,PF02460,000333,Patched
+PF,PF02545,000279,MAF
+PF,PF02608,000067,BMP
+PF,PF02827,000365,PKI
+PF,PF02854,000155,EIF4G
+PF,PF02936,000114,COX4
+PF,PF03039,000253,IL12
+PF,PF03096,000307,NDRG
+PF,PF05392,000118,COX7B
+PF,PF08137,000145,DVL
+PF,PF08562,000121,CRISP
+PF,PF08841,000136,DDR
+PF,PF11413,000230,HIF1
+PF,PF12483,000148,E3_Ub_ligase
+PF,PF15975,000170,FLOT
+RE,R-HSA-1031694,000089,CD64
+RE,R-HSA-109631,000197,GTF2F
+RE,R-HSA-109633,000196,GTF2E
+RE,R-HSA-109782,000404,RAS
+RE,R-HSA-109783,000404,RAS
+RE,R-HSA-109796,000404,RAS
+RE,R-HSA-111854,000370,PLCB
+RE,R-HSA-111864,000212,G_i
+RE,R-HSA-111864,000213,G_i_alpha
+RE,R-HSA-111921,000390,PRKAR
+RE,R-HSA-111923,000390,PRKAR
+RE,R-HSA-111952,000336,PDE1
+RE,R-HSA-111953,000336,PDE1
+RE,R-HSA-111960,000338,PDE4
+RE,R-HSA-114525,000208,G_12_alpha
+RE,R-HSA-114534,000215,G_q
+RE,R-HSA-114534,000216,G_q_alpha
+RE,R-HSA-114547,000207,G_12
+RE,R-HSA-114556,000215,G_q
+RE,R-HSA-114556,000216,G_q_alpha
+RE,R-HSA-114617,000169,Fibrinogen
+RE,R-HSA-114618,000169,Fibrinogen
+RE,R-HSA-114657,000465,TGFB
+RE,R-HSA-114668,000188,GPIb_IX_V
+RE,R-HSA-1168365,000372,PLCG
+RE,R-HSA-1168621,000250,IKK_complex
+RE,R-HSA-1169086,000372,PLCG
+RE,R-HSA-1169089,000372,PLCG
+RE,R-HSA-1218829,000243,HSP90AA
+RE,R-HSA-1221657,000243,HSP90AA
+RE,R-HSA-1227956,000319,NRG_1_2
+RE,R-HSA-1227957,000318,NRG
+RE,R-HSA-1234130,000229,HIF
+RE,R-HSA-1234147,000231,HIF_alpha
+RE,R-HSA-1236898,000089,CD64
+RE,R-HSA-1236905,000089,CD64
+RE,R-HSA-1247495,000319,NRG_1_2
+RE,R-HSA-1248743,000319,NRG_1_2
+RE,R-HSA-1250100,000326,p38
+RE,R-HSA-1250102,000326,p38
+RE,R-HSA-1268261,000161,ERK
+RE,R-HSA-1362227,000464,TFDP
+RE,R-HSA-139848,000324,P2RX
+RE,R-HSA-139933,000169,Fibrinogen
+RE,R-HSA-139934,000169,Fibrinogen
+RE,R-HSA-140586,000169,Fibrinogen
+RE,R-HSA-140812,000469,Thrombin_antithrombin
+RE,R-HSA-140871,000469,Thrombin_antithrombin
+RE,R-HSA-140874,000469,Thrombin_antithrombin
+RE,R-HSA-140919,000169,Fibrinogen
+RE,R-HSA-1445138,000323,p14_3_3
+RE,R-HSA-1449672,000013,Activin_B
+RE,R-HSA-1449688,000256,Inhibin
+RE,R-HSA-1449698,000012,Activin_AB
+RE,R-HSA-1469978,000454,STAT5
+RE,R-HSA-1504201,000145,DVL
+RE,R-HSA-157462,000133,Cyclin_E
+RE,R-HSA-162690,000189,GPIT
+RE,R-HSA-163538,000377,PPP1C
+RE,R-HSA-163679,000042,AMPK_A2B2G2
+RE,R-HSA-163736,000042,AMPK_A2B2G2
+RE,R-HSA-163747,000042,AMPK_A2B2G2
+RE,R-HSA-165175,000482,TSC
+RE,R-HSA-165180,000482,TSC
+RE,R-HSA-1655720,000452,SREBF
+RE,R-HSA-1655725,000452,SREBF
+RE,R-HSA-1655726,000452,SREBF
+RE,R-HSA-1655730,000452,SREBF
+RE,R-HSA-1655732,000452,SREBF
+RE,R-HSA-1655734,000452,SREBF
+RE,R-HSA-165631,000502,ETC_complex_II
+RE,R-HSA-165990,000381,PPP2R_A
+RE,R-HSA-165997,000381,PPP2R_A
+RE,R-HSA-167023,000432,SHC
+RE,R-HSA-167204,000404,RAS
+RE,R-HSA-167215,000448,SOS
+RE,R-HSA-167409,000210,G_beta
+RE,R-HSA-167410,000212,G_i
+RE,R-HSA-167410,000213,G_i_alpha
+RE,R-HSA-167413,000212,G_i
+RE,R-HSA-167413,000213,G_i_alpha
+RE,R-HSA-167438,000212,G_i
+RE,R-HSA-167438,000213,G_i_alpha
+RE,R-HSA-167442,000211,G_gamma
+RE,R-HSA-1678828,000155,EIF4G
+RE,R-HSA-168113,000250,IKK_complex
+RE,R-HSA-169289,000161,ERK
+RE,R-HSA-169291,000161,ERK
+RE,R-HSA-170089,000131,Cyclin_A
+RE,R-HSA-170108,000091,CDC25
+RE,R-HSA-170994,000400,RAL
+RE,R-HSA-170998,000400,RAL
+RE,R-HSA-171016,000326,p38
+RE,R-HSA-171172,000443,SMAD2_3
+RE,R-HSA-171182,000443,SMAD2_3
+RE,R-HSA-173584,000072,C1
+RE,R-HSA-173615,000072,C1
+RE,R-HSA-173617,000072,C1
+RE,R-HSA-173728,000278,MAC
+RE,R-HSA-174074,000131,Cyclin_A
+RE,R-HSA-174454,000411,RFC
+RE,R-HSA-177105,000443,SMAD2_3
+RE,R-HSA-177656,000312,NFkappaB_1
+RE,R-HSA-177662,000312,NFkappaB_1
+RE,R-HSA-177663,000250,IKK_complex
+RE,R-HSA-179508,000025,ALDO
+RE,R-HSA-182582,000132,Cyclin_D
+RE,R-HSA-182700,000132,Cyclin_D
+RE,R-HSA-184196,000349,PDGF_BB
+RE,R-HSA-184198,000349,PDGF_BB
+RE,R-HSA-184203,000347,PDGF_AA
+RE,R-HSA-184204,000349,PDGF_BB
+RE,R-HSA-184206,000349,PDGF_BB
+RE,R-HSA-186769,000343,PDGFR
+RE,R-HSA-186769,000345,PDGFR_AB
+RE,R-HSA-186770,000343,PDGFR
+RE,R-HSA-186770,000345,PDGFR_AB
+RE,R-HSA-186791,000343,PDGFR
+RE,R-HSA-186791,000345,PDGFR_AB
+RE,R-HSA-186792,000343,PDGFR
+RE,R-HSA-186792,000345,PDGFR_AB
+RE,R-HSA-186799,000346,PDGFR_BB
+RE,R-HSA-186805,000346,PDGFR_BB
+RE,R-HSA-186816,000344,PDGFR_AA
+RE,R-HSA-186817,000344,PDGFR_AA
+RE,R-HSA-186821,000343,PDGFR
+RE,R-HSA-186821,000345,PDGFR_AB
+RE,R-HSA-187493,000133,Cyclin_E
+RE,R-HSA-189382,000240,HMOX
+RE,R-HSA-189828,000326,p38
+RE,R-HSA-1911410,000055,ARRB
+RE,R-HSA-1911440,000317,Notch
+RE,R-HSA-1911472,000317,Notch
+RE,R-HSA-1911474,000317,Notch
+RE,R-HSA-1911547,000317,Notch
+RE,R-HSA-1911550,000317,Notch
+RE,R-HSA-195361,000495,VEGF
+RE,R-HSA-195376,000495,VEGF
+RE,R-HSA-196206,000379,PPP2
+RE,R-HSA-198358,000194,GSK3
+RE,R-HSA-198373,000194,GSK3
+RE,R-HSA-198701,000161,ERK
+RE,R-HSA-198899,000090,CD8
+RE,R-HSA-200408,000042,AMPK_A2B2G2
+RE,R-HSA-200563,000005,ACC
+RE,R-HSA-201465,000070,BMP_receptor_type_II
+RE,R-HSA-201689,000145,DVL
+RE,R-HSA-201711,000104,CK2
+RE,R-HSA-201725,000145,DVL
+RE,R-HSA-201779,000384,PPP3C
+RE,R-HSA-201798,000384,PPP3C
+RE,R-HSA-201804,000070,BMP_receptor_type_II
+RE,R-HSA-202052,000023,AKT
+RE,R-HSA-202072,000023,AKT
+RE,R-HSA-202074,000023,AKT
+RE,R-HSA-202088,000023,AKT
+RE,R-HSA-202513,000250,IKK_complex
+RE,R-HSA-202562,000250,IKK_complex
+RE,R-HSA-202877,000082,Caspase_3_7
+RE,R-HSA-2029095,000372,PLCG
+RE,R-HSA-2029115,000494,VAV
+RE,R-HSA-203947,000353,PDK
+RE,R-HSA-206893,000011,Activin_A
+RE,R-HSA-2089970,000109,COL1
+RE,R-HSA-212420,000317,Notch
+RE,R-HSA-2127310,000111,COL5
+RE,R-HSA-2127389,000110,COL4
+RE,R-HSA-2127422,000111,COL5
+RE,R-HSA-2151208,000045,AMPK_beta
+RE,R-HSA-2151212,000046,AMPK_gamma
+RE,R-HSA-2151213,000044,AMPK_alpha
+RE,R-HSA-215989,000273,Laminin_111
+RE,R-HSA-216001,000274,Laminin_332
+RE,R-HSA-2176482,000443,SMAD2_3
+RE,R-HSA-2187329,000443,SMAD2_3
+RE,R-HSA-2187387,000443,SMAD2_3
+RE,R-HSA-2213185,000142,DNM
+RE,R-HSA-2220790,000274,Laminin_332
+RE,R-HSA-2316451,000046,AMPK_gamma
+RE,R-HSA-2317310,000023,AKT
+RE,R-HSA-2317317,000023,AKT
+RE,R-HSA-2317329,000023,AKT
+RE,R-HSA-2395330,000465,TGFB
+RE,R-HSA-2396039,000109,COL1
+RE,R-HSA-2396161,000109,COL1
+RE,R-HSA-2396179,000109,COL1
+RE,R-HSA-2396183,000109,COL1
+RE,R-HSA-2396256,000109,COL1
+RE,R-HSA-2396260,000109,COL1
+RE,R-HSA-2396334,000109,COL1
+RE,R-HSA-2396451,000109,COL1
+RE,R-HSA-2396456,000109,COL1
+RE,R-HSA-2396478,000109,COL1
+RE,R-HSA-2399520,000109,COL1
+RE,R-HSA-2399659,000274,Laminin_332
+RE,R-HSA-2400006,000023,AKT
+RE,R-HSA-2400013,000023,AKT
+RE,R-HSA-2422450,000161,ERK
+RE,R-HSA-2426131,000314,NFY
+RE,R-HSA-2426276,000349,PDGF_BB
+RE,R-HSA-2426371,000273,Laminin_111
+RE,R-HSA-2428941,000109,COL1
+RE,R-HSA-2445131,000264,IRS
+RE,R-HSA-2445139,000264,IRS
+RE,R-HSA-2457842,000323,p14_3_3
+RE,R-HSA-2470478,000010,Activin
+RE,R-HSA-2470478,000012,Activin_AB
+RE,R-HSA-2470491,000010,Activin
+RE,R-HSA-2470491,000012,Activin_AB
+RE,R-HSA-2470494,000010,Activin
+RE,R-HSA-2470494,000012,Activin_AB
+RE,R-HSA-2530496,000172,FNT
+RE,R-HSA-2533911,000274,Laminin_332
+RE,R-HSA-264974,000164,EXOC
+RE,R-HSA-2672035,000473,TN
+RE,R-HSA-2681744,000473,TN
+RE,R-HSA-2685653,000372,PLCG
+RE,R-HSA-2685656,000409,RASGRP
+RE,R-HSA-2990868,000101,Cholinesterase
+RE,R-HSA-2993807,000392,Propionyl_CoA_carboxylase
+RE,R-HSA-2993809,000392,Propionyl_CoA_carboxylase
+RE,R-HSA-3132719,000163,ETS
+RE,R-HSA-3132724,000163,ETS
+RE,R-HSA-3200029,000163,ETS
+RE,R-HSA-3238268,000497,Wnt
+RE,R-HSA-3238374,000497,Wnt
+RE,R-HSA-3247790,000497,Wnt
+RE,R-HSA-3247824,000497,Wnt
+RE,R-HSA-3247835,000497,Wnt
+RE,R-HSA-3299546,000460,TCF_LEF
+RE,R-HSA-3323122,000392,Propionyl_CoA_carboxylase
+RE,R-HSA-3323155,000392,Propionyl_CoA_carboxylase
+RE,R-HSA-3371429,000242,HSP90A
+RE,R-HSA-349716,000306,NCOR
+RE,R-HSA-3640819,000062,AXIN
+RE,R-HSA-3640837,000101,Cholinesterase
+RE,R-HSA-3640863,000062,AXIN
+RE,R-HSA-3656389,000161,ERK
+RE,R-HSA-374848,000215,G_q
+RE,R-HSA-374848,000216,G_q_alpha
+RE,R-HSA-376002,000003,ABL_family
+RE,R-HSA-3772407,000145,DVL
+RE,R-HSA-3772502,000062,AXIN
+RE,R-HSA-378941,000219,hCG
+RE,R-HSA-378947,000175,FSH
+RE,R-HSA-378969,000276,LH
+RE,R-HSA-380748,000349,PDGF_BB
+RE,R-HSA-380751,000349,PDGF_BB
+RE,R-HSA-380759,000348,PDGF_AB
+RE,R-HSA-380759,000349,PDGF_BB
+RE,R-HSA-380931,000031,AMPK
+RE,R-HSA-380934,000031,AMPK
+RE,R-HSA-380961,000031,AMPK
+RE,R-HSA-381204,000314,NFY
+RE,R-HSA-381844,000044,AMPK_alpha
+RE,R-HSA-381845,000044,AMPK_alpha
+RE,R-HSA-381851,000046,AMPK_gamma
+RE,R-HSA-381854,000045,AMPK_beta
+RE,R-HSA-381855,000482,TSC
+RE,R-HSA-381926,000342,PDGF
+RE,R-HSA-381930,000351,PDGF_DD
+RE,R-HSA-381935,000349,PDGF_BB
+RE,R-HSA-381936,000342,PDGF
+RE,R-HSA-381938,000349,PDGF_BB
+RE,R-HSA-381941,000350,PDGF_CC
+RE,R-HSA-3858467,000145,DVL
+RE,R-HSA-3858479,000145,DVL
+RE,R-HSA-387074,000349,PDGF_BB
+RE,R-HSA-388544,000149,EDN
+RE,R-HSA-390455,000085,CCT_complex
+RE,R-HSA-390474,000085,CCT_complex
+RE,R-HSA-390532,000478,Troponin_C
+RE,R-HSA-390541,000479,Troponin_I
+RE,R-HSA-390546,000480,Troponin_T
+RE,R-HSA-390583,000477,Troponin
+RE,R-HSA-390585,000477,Troponin
+RE,R-HSA-390587,000478,Troponin_C
+RE,R-HSA-390643,000021,ADRB
+RE,R-HSA-390664,000020,ADRA2
+RE,R-HSA-390670,000021,ADRB
+RE,R-HSA-390700,000020,ADRA2
+RE,R-HSA-392712,000349,PDGF_BB
+RE,R-HSA-399713,000191,GRIA
+RE,R-HSA-399987,000215,G_q
+RE,R-HSA-399987,000216,G_q_alpha
+RE,R-HSA-399992,000215,G_q
+RE,R-HSA-399992,000216,G_q_alpha
+RE,R-HSA-400000,000215,G_q
+RE,R-HSA-400000,000216,G_q_alpha
+RE,R-HSA-400008,000215,G_q
+RE,R-HSA-400008,000216,G_q_alpha
+RE,R-HSA-400062,000211,G_gamma
+RE,R-HSA-400093,000210,G_beta
+RE,R-HSA-416323,000191,GRIA
+RE,R-HSA-417004,000077,CAMK2_complex
+RE,R-HSA-417004,000078,CAMK2_family
+RE,R-HSA-418312,000430,SERCA
+RE,R-HSA-418379,000391,PRKG
+RE,R-HSA-418540,000340,PDE7
+RE,R-HSA-418541,000341,PDE8
+RE,R-HSA-418570,000207,G_12
+RE,R-HSA-418570,000208,G_12_alpha
+RE,R-HSA-418572,000207,G_12
+RE,R-HSA-418572,000208,G_12_alpha
+RE,R-HSA-419057,000419,ROCK
+RE,R-HSA-419160,000414,RHO
+RE,R-HSA-419161,000414,RHO
+RE,R-HSA-419164,000414,RHO
+RE,R-HSA-419294,000316,NOS
+RE,R-HSA-419346,000427,S1PR
+RE,R-HSA-419401,000427,S1PR
+RE,R-HSA-419619,000242,HSP90A
+RE,R-HSA-420516,000193,GRM
+RE,R-HSA-420519,000193,GRM
+RE,R-HSA-420974,000191,GRIA
+RE,R-HSA-421001,000191,GRIA
+RE,R-HSA-426070,000140,DGK
+RE,R-HSA-427905,000430,SERCA
+RE,R-HSA-428110,000374,PPAP2
+RE,R-HSA-428475,000330,PAK
+RE,R-HSA-429349,000259,INS
+RE,R-HSA-429352,000259,INS
+RE,R-HSA-429384,000259,INS
+RE,R-HSA-429407,000259,INS
+RE,R-HSA-429472,000259,INS
+RE,R-HSA-429842,000153,EIF4A
+RE,R-HSA-430172,000494,VAV
+RE,R-HSA-432792,000077,CAMK2_complex
+RE,R-HSA-432792,000078,CAMK2_family
+RE,R-HSA-434632,000494,VAV
+RE,R-HSA-442272,000494,VAV
+RE,R-HSA-442295,000494,VAV
+RE,R-HSA-442734,000408,RASGRF
+RE,R-HSA-444796,000077,CAMK2_complex
+RE,R-HSA-444796,000078,CAMK2_family
+RE,R-HSA-445134,000333,Patched
+RE,R-HSA-445374,000077,CAMK2_complex
+RE,R-HSA-445374,000078,CAMK2_family
+RE,R-HSA-445744,000252,IL1
+RE,R-HSA-446847,000142,DNM
+RE,R-HSA-446849,000329,P90RSK
+RE,R-HSA-447102,000253,IL12
+RE,R-HSA-448866,000285,MEF2
+RE,R-HSA-448868,000285,MEF2
+RE,R-HSA-450226,000267,JNK
+RE,R-HSA-450253,000267,JNK
+RE,R-HSA-450289,000267,JNK
+RE,R-HSA-451402,000014,ACTN
+RE,R-HSA-452094,000454,STAT5
+RE,R-HSA-4551456,000391,PRKG
+RE,R-HSA-4551462,000391,PRKG
+RE,R-HSA-4641132,000062,AXIN
+RE,R-HSA-4652685,000145,DVL
+RE,R-HSA-4687776,000419,ROCK
+RE,R-HSA-507919,000454,STAT5
+RE,R-HSA-507929,000454,STAT5
+RE,R-HSA-508012,000454,STAT5
+RE,R-HSA-5082395,000242,HSP90A
+RE,R-HSA-5082406,000243,HSP90AA
+RE,R-HSA-5083623,000125,CSNK2
+RE,R-HSA-5083624,000125,CSNK2
+RE,R-HSA-5138439,000105,Clathrin
+RE,R-HSA-5138447,000105,Clathrin
+RE,R-HSA-517388,000177,FZD
+RE,R-HSA-5218789,000494,VAV
+RE,R-HSA-5262981,000250,IKK_complex
+RE,R-HSA-5323539,000460,TCF_LEF
+RE,R-HSA-5333713,000105,Clathrin
+RE,R-HSA-5336141,000047,Annexin_II_heterotetramer
+RE,R-HSA-5340329,000494,VAV
+RE,R-HSA-5358286,000226,Hedgehog
+RE,R-HSA-5358318,000226,Hedgehog
+RE,R-HSA-5358332,000226,Hedgehog
+RE,R-HSA-5362382,000226,Hedgehog
+RE,R-HSA-5362391,000226,Hedgehog
+RE,R-HSA-5610566,000390,PRKAR
+RE,R-HSA-5610568,000390,PRKAR
+RE,R-HSA-5610577,000017,ADCY
+RE,R-HSA-5610578,000017,ADCY
+RE,R-HSA-5618088,000242,HSP90A
+RE,R-HSA-5623453,000164,EXOC
+RE,R-HSA-5656056,000171,FLRT
+RE,R-HSA-5658216,000407,RasGAP
+RE,R-HSA-5658219,000449,SPRED
+RE,R-HSA-5672337,000482,TSC
+RE,R-HSA-5672686,000286,MEK
+RE,R-HSA-5672705,000286,MEK
+RE,R-HSA-5672708,000399,RAF
+RE,R-HSA-5672716,000286,MEK
+RE,R-HSA-5672721,000286,MEK
+RE,R-HSA-5672726,000399,RAF
+RE,R-HSA-5674134,000399,RAF
+RE,R-HSA-5674136,000399,RAF
+RE,R-HSA-5674338,000161,ERK
+RE,R-HSA-5674340,000161,ERK
+RE,R-HSA-5674341,000161,ERK
+RE,R-HSA-5674489,000286,MEK
+RE,R-HSA-5675361,000161,ERK
+RE,R-HSA-5675363,000161,ERK
+RE,R-HSA-5682664,000056,ATG4
+RE,R-HSA-5693120,000064,BCKDC
+RE,R-HSA-5696998,000131,Cyclin_A
+RE,R-HSA-6783051,000131,Cyclin_A
+RE,R-HSA-6792583,000064,BCKDC
+RE,R-HSA-6793931,000276,LH
+RE,R-HSA-6793934,000276,LH
+RE,R-HSA-6798076,000327,p53_family
+RE,R-HSA-6798078,000327,p53_family
+RE,R-HSA-6802607,000404,RAS
+RE,R-HSA-6802608,000404,RAS
+RE,R-HSA-6805064,000125,CSNK2
+RE,R-HSA-6805066,000104,CK2
+RE,R-HSA-6805073,000125,CSNK2
+RE,R-HSA-6805467,000031,AMPK
+RE,R-HSA-6813837,000133,Cyclin_E
+RE,R-HSA-6814207,000210,G_beta
+RE,R-HSA-6814413,000210,G_beta
+RE,R-HSA-6814694,000138,Desmoglein
+RE,R-HSA-68373,000133,Cyclin_E
+RE,R-HSA-68436,000411,RFC
+RE,R-HSA-68450,000141,DNA_polymerase_delta
+RE,R-HSA-68462,000421,RPA
+RE,R-HSA-69261,000091,CDC25
+RE,R-HSA-70019,000064,BCKDC
+RE,R-HSA-70990,000502,ETC_complex_II
+RE,R-HSA-71025,000392,Propionyl_CoA_carboxylase
+RE,R-HSA-71026,000392,Propionyl_CoA_carboxylase
+RE,R-HSA-72526,000152,EIF2B
+RE,R-HSA-727820,000250,IKK_complex
+RE,R-HSA-74674,000259,INS
+RE,R-HSA-74688,000360,PI3K_p85
+RE,R-HSA-749499,000215,G_q
+RE,R-HSA-749499,000216,G_q_alpha
+RE,R-HSA-75202,000131,Cyclin_A
+RE,R-HSA-77385,000259,INS
+RE,R-HSA-8847714,000138,Desmoglein
+RE,R-HSA-8848649,000079,CAPN
+RE,R-HSA-8848668,000079,CAPN
+RE,R-HSA-8849894,000170,FLOT
+RE,R-HSA-8850524,000210,G_beta
+RE,R-HSA-8852568,000278,MAC
+RE,R-HSA-8855211,000061,Augmin
+RE,R-HSA-8861873,000324,P2RX
+RE,R-HSA-8864040,000343,PDGFR
+RE,R-HSA-8864040,000345,PDGFR_AB
+RE,R-HSA-8864046,000346,PDGFR_BB
+RE,R-HSA-8864283,000463,TFAP2
+RE,R-HSA-8864286,000463,TFAP2
+RE,R-HSA-8865622,000454,STAT5
+RE,R-HSA-8866229,000022,ADRBK
+RE,R-HSA-8868235,000142,DNM
+RE,R-HSA-8868609,000142,DNM
+RE,R-HSA-8870680,000169,Fibrinogen
+RE,R-HSA-8936837,000232,HIF_beta
+RE,R-HSA-8938866,000132,Cyclin_D
+RE,R-HSA-8941923,000095,CDKN1
+RE,R-HSA-8942604,000095,CDKN1
+RE,R-HSA-8944354,000460,TCF_LEF
+RE,R-HSA-8948131,000095,CDKN1
+RE,R-HSA-8950122,000253,IL12
+RE,R-HSA-8950228,000253,IL12
+RE,R-HSA-8950694,000253,IL12
+RE,R-HSA-8951427,000460,TCF_LEF
+RE,R-HSA-909688,000246,IFNA
+RE,R-HSA-936779,000057,ATP1A
+RE,R-HSA-936820,000058,ATP1B
+RE,R-HSA-976075,000148,E3_Ub_ligase
+RE,R-HSA-996770,000184,GATA
+SIGNOR,SIGNOR-PF1,000161,ERK
+SIGNOR,SIGNOR-PF10,000145,DVL
+SIGNOR,SIGNOR-PF11,000177,FZD
+SIGNOR,SIGNOR-PF12,000311,NFkappaB
+SIGNOR,SIGNOR-PF13,000330,PAK
+SIGNOR,SIGNOR-PF14,000418,ROBO
+SIGNOR,SIGNOR-PF15,000267,JNK
+SIGNOR,SIGNOR-PF16,000326,p38
+SIGNOR,SIGNOR-PF17,000389,PRKAC
+SIGNOR,SIGNOR-PF18,000384,PPP3C
+SIGNOR,SIGNOR-PF2,000277,LPAR
+SIGNOR,SIGNOR-PF20,000472,TLR
+SIGNOR,SIGNOR-PF21,000458,TAOK
+SIGNOR,SIGNOR-PF22,000462,TEAD
+SIGNOR,SIGNOR-PF23,000168,FGFR
+SIGNOR,SIGNOR-PF24,000023,AKT
+SIGNOR,SIGNOR-PF25,000286,MEK
+SIGNOR,SIGNOR-PF26,000329,P90RSK
+SIGNOR,SIGNOR-PF27,000174,FOXO
+SIGNOR,SIGNOR-PF29,000445,SMURF
+SIGNOR,SIGNOR-PF3,000211,G_gamma
+SIGNOR,SIGNOR-PF30,000317,Notch
+SIGNOR,SIGNOR-PF31,000435,SLRP
+SIGNOR,SIGNOR-PF32,000451,SRC
+SIGNOR,SIGNOR-PF33,000187,GPCR
+SIGNOR,SIGNOR-PF34,000362,PIM
+SIGNOR,SIGNOR-PF35,000442,SMAD1_5_9
+SIGNOR,SIGNOR-PF4,000210,G_beta
+SIGNOR,SIGNOR-PF5,000465,TGFB
+SIGNOR,SIGNOR-PF6,000044,AMPK_alpha
+SIGNOR,SIGNOR-PF7,000323,p14_3_3
+SIGNOR,SIGNOR-PF8,000167,FGF
+SIGNOR,SIGNOR-PF9,000068,BMP_receptor
diff --git a/famplex/resources/famplex.obo b/famplex/resources/famplex.obo
new file mode 100644
index 000000000..56f1b835b
--- /dev/null
+++ b/famplex/resources/famplex.obo
@@ -0,0 +1,8520 @@
+format-version: 1.2
+date: 21:07:2019 16:45
+ 
+[Typedef]
+id: part_of
+name: part of
+namespace: external
+xref: BFO:0000050
+is_transitive: true
+
+[Typedef]
+id: inverse_is_a
+name: inverse is_a
+
+[Typedef]
+id: has_part
+name: has part
+
+[Term]
+id: FPLX:000000
+name: famplex
+
+[Term]
+id: FPLX:000001
+name: 9-1-1
+synonym: "(9-1-1) complex" EXACT []
+synonym: "9-1-1 complex" EXACT []
+synonym: "9-1-1" EXACT []
+synonym: "h9-1-1 complex" EXACT []
+xref: BEL:"9-1-1 Complex"
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:5309 ! HUS1
+relationship: has_part HGNC:9806 ! RAD1
+relationship: has_part HGNC:9827 ! RAD9A
+
+[Term]
+id: FPLX:000002
+name: A4GALT-family
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:18149 ! A4GALT
+relationship: inverse_is_a HGNC:17968 ! A4GNT
+
+[Term]
+id: FPLX:000003
+name: ABL-family
+synonym: "ABL family" EXACT []
+synonym: "ABL" EXACT []
+xref: IP:IPR015015
+xref: MEDSCAN:urn:agi-aopfc:0000567
+xref: RE:R-HSA-376002
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:76 ! ABL1
+relationship: inverse_is_a HGNC:77 ! ABL2
+
+[Term]
+id: FPLX:000004
+name: ACAD
+synonym: "ACAD" EXACT []
+synonym: "acyl CoA dehydrogenase" EXACT []
+synonym: "acyl-CoA dehydrogenase" EXACT []
+xref: BEL:"ACAD Family"
+xref: ECCODE:1.3.8.7
+xref: NEXTPROT-FAMILY:00093
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:87 ! ACAD8
+relationship: inverse_is_a HGNC:21497 ! ACAD9
+relationship: inverse_is_a HGNC:88 ! ACADL
+relationship: inverse_is_a HGNC:89 ! ACADM
+relationship: inverse_is_a HGNC:90 ! ACADS
+relationship: inverse_is_a HGNC:92 ! ACADVL
+relationship: inverse_is_a HGNC:21597 ! ACAD10
+relationship: inverse_is_a HGNC:30211 ! ACAD11
+relationship: inverse_is_a HGNC:91 ! ACADSB
+relationship: inverse_is_a HGNC:4189 ! GCDH
+relationship: inverse_is_a HGNC:6186 ! IVD
+
+[Term]
+id: FPLX:000005
+name: ACC
+synonym: "ACC" EXACT []
+synonym: "ACCs" EXACT []
+synonym: "Acetyl Coenzyme A Carboxylase" EXACT []
+synonym: "Acetyl-CoA carboxylase" EXACT []
+synonym: "acetyl-CoA carboxylase" EXACT []
+xref: BEL:"Acetyl CoA Carboxylase Complex"
+xref: ECCODE:6.4.1.2
+xref: IP:IPR013537
+xref: RE:R-HSA-200563
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:84 ! ACACA
+relationship: has_part HGNC:85 ! ACACB
+
+[Term]
+id: FPLX:000006
+name: Acetyl-CoA-synthetase
+synonym: "Acetate-CoA ligase" EXACT []
+synonym: "acetyl CoA ligase" EXACT []
+synonym: "acetyl CoA synthase" EXACT []
+synonym: "Acetyl-CoA synthetase" EXACT []
+synonym: "acetyl-CoA synthetase" EXACT []
+synonym: "acetyl-coenzyme A synthase" EXACT []
+synonym: "ACS" EXACT []
+xref: BEL:"Acetyl-CoA Synthetase Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10996 ! SLC27A2
+relationship: inverse_is_a HGNC:3569 ! ACSL1
+relationship: inverse_is_a HGNC:3570 ! ACSL3
+relationship: inverse_is_a HGNC:3571 ! ACSL4
+relationship: inverse_is_a HGNC:16526 ! ACSL5
+relationship: inverse_is_a HGNC:16496 ! ACSL6
+
+[Term]
+id: FPLX:000007
+name: ACOX
+synonym: "Acyl-CoA Oxidase" EXACT []
+synonym: "acyl-CoA oxidases" EXACT []
+xref: BEL:"ACOX Family"
+xref: IP:IPR002655
+xref: XFAM:PF01756
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:119 ! ACOX1
+relationship: inverse_is_a HGNC:120 ! ACOX2
+relationship: inverse_is_a HGNC:121 ! ACOX3
+relationship: inverse_is_a HGNC:25621 ! ACOXL
+
+[Term]
+id: FPLX:000008
+name: ACSL
+synonym: "Acsl" EXACT []
+synonym: "long-chain acyl-CoA synthetase" EXACT []
+xref: BEL:"ACSL Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3569 ! ACSL1
+relationship: inverse_is_a HGNC:3570 ! ACSL3
+relationship: inverse_is_a HGNC:3571 ! ACSL4
+relationship: inverse_is_a HGNC:16526 ! ACSL5
+relationship: inverse_is_a HGNC:16496 ! ACSL6
+
+[Term]
+id: FPLX:000009
+name: Actin
+synonym: "actin filament" EXACT []
+synonym: "actin" EXACT []
+synonym: "actins" EXACT []
+xref: BEL:"ACT Family"
+xref: GO:0005884
+xref: IP:IPR004000
+xref: MEDSCAN:urn:agi-protfc:actins
+xref: MESH:D000199
+xref: NCIT:C16258
+xref: NEXTPROT-FAMILY:00078
+xref: XFAM:PF00022
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:129 ! ACTA1
+relationship: inverse_is_a HGNC:130 ! ACTA2
+relationship: inverse_is_a HGNC:132 ! ACTB
+relationship: inverse_is_a HGNC:143 ! ACTC1
+relationship: inverse_is_a HGNC:144 ! ACTG1
+relationship: inverse_is_a HGNC:145 ! ACTG2
+relationship: inverse_is_a FPLX:000178 ! F_actin
+
+[Term]
+id: FPLX:000010
+name: Activin
+synonym: "activin protein" EXACT []
+synonym: "Activin" EXACT []
+synonym: "activin" EXACT []
+synonym: "activins" EXACT []
+xref: GO:0048180
+xref: NCIT:C20456
+xref: RE:R-HSA-2470478
+xref: RE:R-HSA-2470491
+xref: RE:R-HSA-2470494
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000011 ! Activin_A
+relationship: inverse_is_a FPLX:000012 ! Activin_AB
+relationship: inverse_is_a FPLX:000013 ! Activin_B
+
+[Term]
+id: FPLX:000011
+name: Activin-A
+synonym: "Activin A protein" EXACT []
+synonym: "Activin A" EXACT []
+synonym: "activin A" EXACT []
+synonym: "activin-A" EXACT []
+synonym: "activinA" EXACT []
+xref: GO:0043509
+xref: IP:IPR000491
+xref: RE:R-HSA-206893
+is_a: FPLX:000010 ! Activin
+relationship: has_part HGNC:6066 ! INHBA
+
+[Term]
+id: FPLX:000012
+name: Activin-AB
+synonym: "activin AB" EXACT []
+xref: RE:R-HSA-1449698
+xref: RE:R-HSA-2470478
+xref: RE:R-HSA-2470491
+xref: RE:R-HSA-2470494
+is_a: FPLX:000010 ! Activin
+relationship: has_part HGNC:6066 ! INHBA
+relationship: has_part HGNC:6067 ! INHBB
+
+[Term]
+id: FPLX:000013
+name: Activin-B
+synonym: "activin-B" EXACT []
+xref: IP:IPR000381
+xref: RE:R-HSA-1449672
+is_a: FPLX:000010 ! Activin
+relationship: has_part HGNC:6067 ! INHBB
+
+[Term]
+id: FPLX:000014
+name: ACTN
+synonym: "actinin" EXACT []
+xref: BEL:"ACTN Family"
+xref: RE:R-HSA-451402
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:163 ! ACTN1
+relationship: inverse_is_a HGNC:164 ! ACTN2
+relationship: inverse_is_a HGNC:165 ! ACTN3
+relationship: inverse_is_a HGNC:166 ! ACTN4
+
+[Term]
+id: FPLX:000015
+name: Adaptor-protein-II
+synonym: "Adaptor Protein 2 complex" EXACT []
+synonym: "adaptor protein complex 2" EXACT []
+synonym: "AP-2 adaptor complex" EXACT []
+synonym: "AP-2 complex" EXACT []
+synonym: "AP-2" EXACT []
+synonym: "AP2 adaptor complex" EXACT []
+synonym: "AP2 clathrin adaptor complex" EXACT []
+synonym: "AP2 complex" EXACT []
+synonym: "AP2" EXACT []
+xref: BEL:"Adaptor Protein II Complex"
+xref: GO:0030122
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:563 ! AP2B1
+relationship: has_part HGNC:564 ! AP2M1
+relationship: has_part HGNC:565 ! AP2S1
+relationship: has_part FPLX:000049 ! AP2A
+
+[Term]
+id: FPLX:000016
+name: Adaptor-protein-III
+synonym: "adaptor protein complex 3" EXACT []
+synonym: "AP-3" EXACT []
+synonym: "AP3" EXACT []
+xref: BEL:"Adaptor Protein III Complex"
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:566 ! AP3B1
+relationship: has_part HGNC:568 ! AP3D1
+relationship: has_part HGNC:2013 ! AP3S1
+relationship: has_part HGNC:571 ! AP3S2
+
+[Term]
+id: FPLX:000017
+name: ADCY
+synonym: "adenylate cyclase" EXACT []
+synonym: "adenylyl cyclase" EXACT []
+xref: BEL:"ADCY Family"
+xref: NCIT:C16264
+xref: RE:R-HSA-5610577
+xref: RE:R-HSA-5610578
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:232 ! ADCY1
+relationship: inverse_is_a HGNC:233 ! ADCY2
+relationship: inverse_is_a HGNC:234 ! ADCY3
+relationship: inverse_is_a HGNC:235 ! ADCY4
+relationship: inverse_is_a HGNC:236 ! ADCY5
+relationship: inverse_is_a HGNC:237 ! ADCY6
+relationship: inverse_is_a HGNC:238 ! ADCY7
+relationship: inverse_is_a HGNC:239 ! ADCY8
+relationship: inverse_is_a HGNC:240 ! ADCY9
+relationship: inverse_is_a HGNC:21285 ! ADCY10
+
+[Term]
+id: FPLX:000018
+name: ADH
+synonym: "alcohol dehydrogenase" EXACT []
+xref: BEL:"ADH Family"
+xref: ECCODE:1.1.1.1
+xref: NCIT:C16272
+xref: XFAM:PF00465
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:249 ! ADH1A
+relationship: inverse_is_a HGNC:250 ! ADH1B
+relationship: inverse_is_a HGNC:251 ! ADH1C
+relationship: inverse_is_a HGNC:252 ! ADH4
+relationship: inverse_is_a HGNC:253 ! ADH5
+relationship: inverse_is_a HGNC:255 ! ADH6
+relationship: inverse_is_a HGNC:256 ! ADH7
+relationship: inverse_is_a HGNC:16354 ! ADHFE1
+
+[Term]
+id: FPLX:000019
+name: ADRA
+synonym: "a-adrenoreceptor" EXACT []
+synonym: "alpha adrenoceptor" EXACT []
+synonym: "alpha-adrenergic receptor" EXACT []
+synonym: "alpha-adrenoreceptor" EXACT []
+synonym: "alpha-adrenoreceptors" EXACT []
+synonym: "alpha1 adrenoceptor" EXACT []
+synonym: "α-adrenergic receptor" EXACT []
+synonym: "α-adrenoreceptor" EXACT []
+synonym: "α-adrenoreceptors" EXACT []
+xref: BEL:"ADRA Family"
+xref: GO:0004936
+xref: GO:0004937
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:277 ! ADRA1A
+relationship: inverse_is_a HGNC:278 ! ADRA1B
+relationship: inverse_is_a HGNC:280 ! ADRA1D
+relationship: inverse_is_a HGNC:281 ! ADRA2A
+relationship: inverse_is_a HGNC:282 ! ADRA2B
+relationship: inverse_is_a HGNC:283 ! ADRA2C
+
+[Term]
+id: FPLX:000020
+name: ADRA2
+synonym: "alpha(2)-adrenoceptors" EXACT []
+synonym: "alpha(2)-ARs" EXACT []
+synonym: "alpha2 adrenoceptor" EXACT []
+synonym: "alpha2-AR" EXACT []
+synonym: "ofalpha(2)-adrenoceptor" EXACT []
+synonym: "ofα(2)-adrenoceptor" EXACT []
+synonym: "α(2)-adrenoceptors" EXACT []
+synonym: "α(2)-ARs" EXACT []
+synonym: "α2-AR" EXACT []
+xref: BEL:"ADRA2 Family"
+xref: GO:0004938
+xref: RE:R-HSA-390664
+xref: RE:R-HSA-390700
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:281 ! ADRA2A
+relationship: inverse_is_a HGNC:282 ! ADRA2B
+relationship: inverse_is_a HGNC:283 ! ADRA2C
+
+[Term]
+id: FPLX:000021
+name: ADRB
+synonym: "b-adrenergic receptor" EXACT []
+synonym: "b-receptors" EXACT []
+synonym: "beta-adrenergic receptor" EXACT []
+synonym: "beta-adrenoreceptor" EXACT []
+synonym: "betaAR" EXACT []
+synonym: "β-adrenergic receptor" EXACT []
+synonym: "β-adrenoreceptor" EXACT []
+synonym: "βAR" EXACT []
+xref: BEL:"ADRB Family"
+xref: NCIT:C17062
+xref: RE:R-HSA-390643
+xref: RE:R-HSA-390670
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:285 ! ADRB1
+relationship: inverse_is_a HGNC:286 ! ADRB2
+relationship: inverse_is_a HGNC:288 ! ADRB3
+
+[Term]
+id: FPLX:000022
+name: ADRBK
+synonym: "BARK" EXACT []
+synonym: "beta adrenergic receptor kinase" EXACT []
+synonym: "betaARK" EXACT []
+synonym: "β adrenergic receptor kinase" EXACT []
+synonym: "βARK" EXACT []
+xref: BEL:"ADRBK Family"
+xref: RE:R-HSA-8866229
+is_a: FPLX:000192 ! GRK
+relationship: inverse_is_a HGNC:289 ! GRK2
+relationship: inverse_is_a HGNC:290 ! GRK3
+
+[Term]
+id: FPLX:000023
+name: AKT
+synonym: "AKT family" EXACT []
+synonym: "AKT" EXACT []
+synonym: "Akt" EXACT []
+synonym: "PKB" EXACT []
+synonym: "PKB-Akt" EXACT []
+synonym: "PKB/Akt" EXACT []
+xref: BEL:"AKT Family"
+xref: MEDSCAN:urn:agi-aopfc:0000439
+xref: NCIT:C41625
+xref: RE:R-HSA-202052
+xref: RE:R-HSA-202072
+xref: RE:R-HSA-202074
+xref: RE:R-HSA-202088
+xref: RE:R-HSA-2317310
+xref: RE:R-HSA-2317317
+xref: RE:R-HSA-2317329
+xref: RE:R-HSA-2400006
+xref: RE:R-HSA-2400013
+xref: SIGNOR:SIGNOR-PF24
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:391 ! AKT1
+relationship: inverse_is_a HGNC:392 ! AKT2
+relationship: inverse_is_a HGNC:393 ! AKT3
+
+[Term]
+id: FPLX:000024
+name: ALDH
+synonym: "aldehyde dehydrogenase (NAD+)" EXACT []
+synonym: "Aldehyde dehydrogenase" EXACT []
+synonym: "aldehyde dehydrogenase" EXACT []
+synonym: "ALDH" EXACT []
+xref: BEL:"ALDH Family"
+xref: ECCODE:1.2.1.3
+xref: NCIT:C118481
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:402 ! ALDH1A1
+relationship: inverse_is_a HGNC:15472 ! ALDH1A2
+relationship: inverse_is_a HGNC:409 ! ALDH1A3
+relationship: inverse_is_a HGNC:404 ! ALDH2
+relationship: inverse_is_a HGNC:405 ! ALDH3A1
+relationship: inverse_is_a HGNC:403 ! ALDH3A2
+relationship: inverse_is_a HGNC:410 ! ALDH3B1
+relationship: inverse_is_a HGNC:408 ! ALDH5A1
+relationship: inverse_is_a HGNC:877 ! ALDH7A1
+relationship: inverse_is_a HGNC:412 ! ALDH9A1
+
+[Term]
+id: FPLX:000025
+name: ALDO
+synonym: "ALDO" EXACT []
+synonym: "fructose-bisphosphate aldolase" EXACT []
+xref: BEL:"ALDO Family"
+xref: ECCODE:4.1.2.13
+xref: IP:IPR000741
+xref: IP:IPR029768
+xref: RE:R-HSA-179508
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:414 ! ALDOA
+relationship: inverse_is_a HGNC:417 ! ALDOB
+relationship: inverse_is_a HGNC:418 ! ALDOC
+
+[Term]
+id: FPLX:000026
+name: ALG10
+synonym: "ALG10" EXACT []
+synonym: "Alpha-1,2-glucosyltransferase" EXACT []
+synonym: "Alpha-1,2-glucosyltransferases" EXACT []
+synonym: "alpha-1,2-glucosyltransferase" EXACT []
+synonym: "alpha-1,2-glucosyltransferases" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:23162 ! ALG10
+relationship: inverse_is_a HGNC:31088 ! ALG10B
+
+[Term]
+id: FPLX:000027
+name: ALG1-family
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:18294 ! ALG1
+relationship: inverse_is_a HGNC:33721 ! ALG1L
+relationship: inverse_is_a HGNC:37258 ! ALG1L2
+relationship: inverse_is_a HGNC:23159 ! ALG2
+relationship: inverse_is_a HGNC:32456 ! ALG11
+relationship: inverse_is_a HGNC:26483 ! GLT1D1
+relationship: inverse_is_a HGNC:20887 ! GTDC1
+relationship: inverse_is_a HGNC:4706 ! GYS1
+relationship: inverse_is_a HGNC:4707 ! GYS2
+relationship: inverse_is_a HGNC:8957 ! PIGA
+
+[Term]
+id: FPLX:000028
+name: ALG3-family
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:23056 ! ALG3
+relationship: inverse_is_a HGNC:15672 ! ALG9
+relationship: inverse_is_a HGNC:19358 ! ALG12
+relationship: inverse_is_a HGNC:8959 ! PIGB
+relationship: inverse_is_a HGNC:18858 ! PIGM
+relationship: inverse_is_a HGNC:26031 ! PIGV
+relationship: inverse_is_a HGNC:30596 ! PIGZ
+relationship: inverse_is_a HGNC:9202 ! POMT1
+relationship: inverse_is_a HGNC:19743 ! POMT2
+
+[Term]
+id: FPLX:000029
+name: ALG6-family
+synonym: "Alpha-1,3-glucosyltransferase" EXACT []
+synonym: "Alpha-1,3-glucosyltransferases" EXACT []
+synonym: "alpha-1,3-glucosyltransferase" EXACT []
+synonym: "alpha-1,3-glucosyltransferases" EXACT []
+synonym: "Alpha-1,4-glucosyltransferase" EXACT []
+synonym: "Alpha-1,4-glucosyltransferases" EXACT []
+synonym: "alpha-1,4-glucosyltransferase" EXACT []
+synonym: "alpha-1,4-glucosyltransferases" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:23157 ! ALG6
+relationship: inverse_is_a HGNC:23161 ! ALG8
+
+[Term]
+id: FPLX:000030
+name: ALG13-family
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:30881 ! ALG13
+relationship: inverse_is_a HGNC:28287 ! ALG14
+
+[Term]
+id: FPLX:000031
+name: AMPK
+synonym: "AMPK" EXACT []
+xref: BEL:"AMP Activated Protein Kinase Complex"
+xref: ECCODE:2.7.11.31
+xref: MEDSCAN:urn:agi-protfc:AMPK
+xref: NCIT:C94701
+xref: NEXTPROT-FAMILY:03071
+xref: RE:R-HSA-380931
+xref: RE:R-HSA-380934
+xref: RE:R-HSA-380961
+xref: RE:R-HSA-6805467
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000032 ! AMPK_A1B1G1
+relationship: inverse_is_a FPLX:000033 ! AMPK_A1B1G2
+relationship: inverse_is_a FPLX:000034 ! AMPK_A1B1G3
+relationship: inverse_is_a FPLX:000035 ! AMPK_A1B2G1
+relationship: inverse_is_a FPLX:000036 ! AMPK_A1B2G2
+relationship: inverse_is_a FPLX:000037 ! AMPK_A1B2G3
+relationship: inverse_is_a FPLX:000038 ! AMPK_A2B1G1
+relationship: inverse_is_a FPLX:000039 ! AMPK_A2B1G2
+relationship: inverse_is_a FPLX:000040 ! AMPK_A2B1G3
+relationship: inverse_is_a FPLX:000041 ! AMPK_A2B2G1
+relationship: inverse_is_a FPLX:000042 ! AMPK_A2B2G2
+relationship: inverse_is_a FPLX:000043 ! AMPK_A2B2G3
+relationship: has_part FPLX:000044 ! AMPK_alpha
+relationship: has_part FPLX:000045 ! AMPK_beta
+relationship: has_part FPLX:000046 ! AMPK_gamma
+
+[Term]
+id: FPLX:000032
+name: AMPK-A1B1G1
+synonym: "AMPK (alpha 1, beta 1, gamma 1)" EXACT []
+synonym: "AMPK (α 1, β 1, γ 1)" EXACT []
+synonym: "alpha1beta1gamma1" EXACT []
+synonym: "AMPK (A1/B1/G1)" EXACT []
+synonym: "AMPK a1b1g1" EXACT []
+synonym: "AMPK alpha1beta1gamma1" EXACT []
+synonym: "AMPK α1β1γ1" EXACT []
+synonym: "α1β1γ1" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9385 ! PRKAG1
+
+[Term]
+id: FPLX:000033
+name: AMPK-A1B1G2
+synonym: "AMPK (alpha 1, beta 1, gamma 2)" EXACT []
+synonym: "AMPK (α 1, β 1, γ 2)" EXACT []
+synonym: "alpha1beta1gamma2" EXACT []
+synonym: "AMPK (A1/B1/G2)" EXACT []
+synonym: "AMPK a1b1g2" EXACT []
+synonym: "AMPK alpha1beta1gamma2" EXACT []
+synonym: "AMPK α1β1γ2" EXACT []
+synonym: "α1β1γ2" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9386 ! PRKAG2
+
+[Term]
+id: FPLX:000034
+name: AMPK-A1B1G3
+synonym: "AMPK (alpha 1, beta 1, gamma 3)" EXACT []
+synonym: "AMPK (α 1, β 1, γ 3)" EXACT []
+synonym: "alpha1beta1gamma3" EXACT []
+synonym: "AMPK (A1/B1/G3)" EXACT []
+synonym: "AMPK a1b1g3" EXACT []
+synonym: "AMPK alpha1beta1gamma3" EXACT []
+synonym: "AMPK α1β1γ3" EXACT []
+synonym: "α1β1γ3" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9387 ! PRKAG3
+
+[Term]
+id: FPLX:000035
+name: AMPK-A1B2G1
+synonym: "AMPK (alpha 1, beta 2, gamma 1)" EXACT []
+synonym: "AMPK (α 1, β 2, γ 1)" EXACT []
+synonym: "alpha1beta2gamma1" EXACT []
+synonym: "AMPK (A1/B2/G1)" EXACT []
+synonym: "AMPK a1b2g1" EXACT []
+synonym: "AMPK alpha1beta2gamma1" EXACT []
+synonym: "AMPK α1β2γ1" EXACT []
+synonym: "α1β2γ1" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9385 ! PRKAG1
+
+[Term]
+id: FPLX:000036
+name: AMPK-A1B2G2
+synonym: "AMPK (alpha 1, beta 2, gamma 2)" EXACT []
+synonym: "AMPK (α 1, β 2, γ 2)" EXACT []
+synonym: "alpha1beta2gamma2" EXACT []
+synonym: "AMPK (A1/B2/G2)" EXACT []
+synonym: "AMPK a1b2g2" EXACT []
+synonym: "AMPK alpha1beta2gamma2" EXACT []
+synonym: "AMPK α1β2γ2" EXACT []
+synonym: "α1β2γ2" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9386 ! PRKAG2
+
+[Term]
+id: FPLX:000037
+name: AMPK-A1B2G3
+synonym: "AMPK (alpha 1, beta 2, gamma 3)" EXACT []
+synonym: "AMPK (α 1, β 2, γ 3)" EXACT []
+synonym: "AMPK (A1/B2/G3)" EXACT []
+synonym: "AMPK alpha1beta2gamma3" EXACT []
+synonym: "AMPK α1β2γ3" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9376 ! PRKAA1
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9387 ! PRKAG3
+
+[Term]
+id: FPLX:000038
+name: AMPK-A2B1G1
+synonym: "AMPK (alpha 2, beta 1, gamma 1)" EXACT []
+synonym: "AMPK (α 2, β 1, γ 1)" EXACT []
+synonym: "alpha2beta1gamma1" EXACT []
+synonym: "AMPK (A2/B1/G1)" EXACT []
+synonym: "AMPK a2b1g1" EXACT []
+synonym: "AMPK alpha2beta1gamma1" EXACT []
+synonym: "AMPK α2β1γ1" EXACT []
+synonym: "α2β1γ1" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9385 ! PRKAG1
+
+[Term]
+id: FPLX:000039
+name: AMPK-A2B1G2
+synonym: "AMPK (alpha 2, beta 1, gamma 2)" EXACT []
+synonym: "AMPK (α 2, β 1, γ 2)" EXACT []
+synonym: "AMPK (A2/B1/G2)" EXACT []
+synonym: "AMPK alpha2beta1gamma2" EXACT []
+synonym: "AMPK α2β1γ2" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9386 ! PRKAG2
+
+[Term]
+id: FPLX:000040
+name: AMPK-A2B1G3
+synonym: "AMPK (alpha 2, beta 1, gamma 3)" EXACT []
+synonym: "AMPK (α 2, β 1, γ 3)" EXACT []
+synonym: "AMPK (A2/B1/G3)" EXACT []
+synonym: "AMPK alpha2beta1gamma3" EXACT []
+synonym: "AMPK α2β1γ3" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9378 ! PRKAB1
+relationship: has_part HGNC:9387 ! PRKAG3
+
+[Term]
+id: FPLX:000041
+name: AMPK-A2B2G1
+synonym: "AMPK (alpha 2, beta 2, gamma 1)" EXACT []
+synonym: "AMPK (α 2, β 2, γ 1)" EXACT []
+synonym: "alpha2beta2gamma1" EXACT []
+synonym: "AMPK (A2/B2/G1)" EXACT []
+synonym: "AMPK a2b2g1" EXACT []
+synonym: "AMPK alpha2beta2gamma1" EXACT []
+synonym: "AMPK α2β2γ1" EXACT []
+synonym: "α2β2γ1" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9385 ! PRKAG1
+
+[Term]
+id: FPLX:000042
+name: AMPK-A2B2G2
+synonym: "AMPK (alpha 2, beta 2, gamma 2)" EXACT []
+synonym: "AMPK (α 2, β 2, γ 2)" EXACT []
+synonym: "alpha2beta2gamma2" EXACT []
+synonym: "AMPK (A2/B2/G2)" EXACT []
+synonym: "AMPK a2b2g2" EXACT []
+synonym: "AMPK alpha2beta2gamma2" EXACT []
+synonym: "AMPK α2β2γ2" EXACT []
+synonym: "α2β2γ2" EXACT []
+xref: RE:R-HSA-163679
+xref: RE:R-HSA-163736
+xref: RE:R-HSA-163747
+xref: RE:R-HSA-200408
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9386 ! PRKAG2
+
+[Term]
+id: FPLX:000043
+name: AMPK-A2B2G3
+synonym: "AMPK (alpha 2, beta 2, gamma 3)" EXACT []
+synonym: "AMPK (α 2, β 2, γ 3)" EXACT []
+synonym: "alpha2beta2gamma3" EXACT []
+synonym: "AMPK (A2/B2/G3)" EXACT []
+synonym: "AMPK a2b2g3" EXACT []
+synonym: "AMPK alpha2beta2gamma3" EXACT []
+synonym: "AMPK α2β2γ3" EXACT []
+synonym: "α2β2γ3" EXACT []
+is_a: FPLX:000031 ! AMPK
+relationship: has_part HGNC:9377 ! PRKAA2
+relationship: has_part HGNC:9379 ! PRKAB2
+relationship: has_part HGNC:9387 ! PRKAG3
+
+[Term]
+id: FPLX:000044
+name: AMPK-alpha
+synonym: "AMPKalpha" EXACT []
+synonym: "AMPKα" EXACT []
+synonym: "PRKAA" EXACT []
+xref: BEL:"PRKAA Family"
+xref: IP:IPR032270
+xref: NCIT:C116019
+xref: RE:R-HSA-2151213
+xref: RE:R-HSA-381844
+xref: RE:R-HSA-381845
+xref: SIGNOR:SIGNOR-PF6
+relationship: part_of FPLX:000031 ! AMPK
+relationship: inverse_is_a HGNC:9376 ! PRKAA1
+relationship: inverse_is_a HGNC:9377 ! PRKAA2
+
+[Term]
+id: FPLX:000045
+name: AMPK-beta
+synonym: "PRKAB" EXACT []
+xref: BEL:"PRKAB Family"
+xref: IP:IPR006828
+xref: IP:IPR032640
+xref: RE:R-HSA-2151208
+xref: RE:R-HSA-381854
+relationship: part_of FPLX:000031 ! AMPK
+relationship: inverse_is_a HGNC:9378 ! PRKAB1
+relationship: inverse_is_a HGNC:9379 ! PRKAB2
+
+[Term]
+id: FPLX:000046
+name: AMPK-gamma
+synonym: "PRKAG" EXACT []
+xref: BEL:"PRKAG Family"
+xref: RE:R-HSA-2151212
+xref: RE:R-HSA-2316451
+xref: RE:R-HSA-381851
+relationship: part_of FPLX:000031 ! AMPK
+relationship: inverse_is_a HGNC:9385 ! PRKAG1
+relationship: inverse_is_a HGNC:9386 ! PRKAG2
+relationship: inverse_is_a HGNC:9387 ! PRKAG3
+
+[Term]
+id: FPLX:000047
+name: Annexin-II-heterotetramer
+synonym: "A2t" EXACT []
+synonym: "annexin A2 heterotetramer" EXACT []
+synonym: "annexin II heterotetramer" EXACT []
+synonym: "ANXA2 heterotetramer" EXACT []
+xref: BEL:"Annexin II Heterotetramer Complex"
+xref: RE:R-HSA-5336141
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:537 ! ANXA2
+relationship: has_part HGNC:10487 ! S100A10
+
+[Term]
+id: FPLX:000048
+name: AP1
+synonym: "AP-1" EXACT []
+synonym: "AP1" EXACT []
+xref: BEL:"AP-1 Complex"
+xref: MESH:D018808
+xref: NCIT:C17450
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000173 ! FOS_family
+relationship: has_part FPLX:000268 ! JUN_family
+
+[Term]
+id: FPLX:000049
+name: AP2A
+xref: IP:IPR017104
+relationship: part_of FPLX:000015 ! Adaptor_protein_II
+relationship: inverse_is_a HGNC:561 ! AP2A1
+relationship: inverse_is_a HGNC:562 ! AP2A2
+
+[Term]
+id: FPLX:000050
+name: APC-C
+synonym: "APC/C" EXACT []
+xref: GO:0005680
+xref: MEDSCAN:urn:agi-aopfc:0000571
+xref: MEDSCAN:urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:19989 ! ANAPC2
+relationship: has_part HGNC:14452 ! ANAPC11
+relationship: has_part HGNC:19988 ! ANAPC1
+relationship: has_part HGNC:1720 ! CDC16
+relationship: has_part HGNC:1728 ! CDC27
+relationship: has_part HGNC:1724 ! CDC23
+relationship: has_part HGNC:15713 ! ANAPC5
+relationship: has_part HGNC:24077 ! ANAPC10
+relationship: has_part HGNC:24531 ! ANAPC15
+relationship: has_part HGNC:24540 ! ANAPC13
+relationship: has_part HGNC:17839 ! CDC26
+relationship: has_part HGNC:26976 ! ANAPC16
+relationship: has_part HGNC:17380 ! ANAPC7
+relationship: has_part HGNC:19990 ! ANAPC4
+
+[Term]
+id: FPLX:000051
+name: APOA
+synonym: "ApoA" EXACT []
+synonym: "apoA" EXACT []
+synonym: "apolipoprotein (a)" EXACT []
+synonym: "apolipoprotein A" EXACT []
+synonym: "apolipoprotein(A)" EXACT []
+synonym: "apolipoprotein(a)" EXACT []
+xref: BEL:"APOA Family"
+xref: NCIT:C105952
+is_a: FPLX:000052 ! Apolipoprotein
+relationship: inverse_is_a HGNC:600 ! APOA1
+relationship: inverse_is_a HGNC:601 ! APOA2
+relationship: inverse_is_a HGNC:602 ! APOA4
+relationship: inverse_is_a HGNC:17288 ! APOA5
+
+[Term]
+id: FPLX:000052
+name: Apolipoprotein
+synonym: "Apolipoprotein" EXACT []
+synonym: "apolipoprotein" EXACT []
+synonym: "apolipoproteins" EXACT []
+xref: IP:IPR000074
+xref: MEDSCAN:urn:agi-protfc:apolipoprotein
+xref: XFAM:PF01442
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000051 ! APOA
+relationship: inverse_is_a HGNC:613 ! APOE
+
+[Term]
+id: FPLX:000053
+name: ARF-GTPase-family
+synonym: "ADP ribosylation factor" EXACT []
+synonym: "ARF" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:660 ! TRIM23
+relationship: inverse_is_a HGNC:652 ! ARF1
+relationship: inverse_is_a HGNC:654 ! ARF3
+relationship: inverse_is_a HGNC:655 ! ARF4
+relationship: inverse_is_a HGNC:658 ! ARF5
+relationship: inverse_is_a HGNC:659 ! ARF6
+relationship: inverse_is_a HGNC:692 ! ARL1
+relationship: inverse_is_a HGNC:693 ! ARL2
+relationship: inverse_is_a HGNC:694 ! ARL3
+relationship: inverse_is_a HGNC:695 ! ARL4A
+relationship: inverse_is_a HGNC:698 ! ARL4C
+relationship: inverse_is_a HGNC:656 ! ARL4D
+relationship: inverse_is_a HGNC:696 ! ARL5A
+relationship: inverse_is_a HGNC:23052 ! ARL5B
+relationship: inverse_is_a HGNC:31111 ! ARL5C
+relationship: inverse_is_a HGNC:13210 ! ARL6
+relationship: inverse_is_a HGNC:25192 ! ARL8A
+relationship: inverse_is_a HGNC:25564 ! ARL8B
+relationship: inverse_is_a HGNC:23592 ! ARL9
+relationship: inverse_is_a HGNC:22042 ! ARL10
+relationship: inverse_is_a HGNC:24046 ! ARL11
+relationship: inverse_is_a HGNC:31709 ! ARL13A
+relationship: inverse_is_a HGNC:25419 ! ARL13B
+relationship: inverse_is_a HGNC:22974 ! ARL14
+relationship: inverse_is_a HGNC:25945 ! ARL15
+relationship: inverse_is_a HGNC:27902 ! ARL16
+relationship: inverse_is_a HGNC:24096 ! ARL17A
+relationship: inverse_is_a HGNC:32387 ! ARL17B
+relationship: inverse_is_a HGNC:662 ! ARFRP1
+relationship: inverse_is_a HGNC:10534 ! SAR1A
+relationship: inverse_is_a HGNC:10535 ! SAR1B
+
+[Term]
+id: FPLX:000054
+name: Arp2-3-protein
+synonym: "Arp2/3" EXACT []
+xref: BEL:"Arp2/3 Protein Complex"
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:703 ! ARPC1A
+relationship: has_part HGNC:704 ! ARPC1B
+relationship: has_part HGNC:705 ! ARPC2
+relationship: has_part HGNC:706 ! ARPC3
+relationship: has_part HGNC:707 ! ARPC4
+relationship: has_part HGNC:708 ! ARPC5
+relationship: has_part HGNC:23366 ! ARPC5L
+
+[Term]
+id: FPLX:000055
+name: ARRB
+synonym: "b-arrestin" EXACT []
+synonym: "barrestins" EXACT []
+xref: BEL:"ARRB Family"
+xref: RE:R-HSA-1911410
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:711 ! ARRB1
+relationship: inverse_is_a HGNC:712 ! ARRB2
+
+[Term]
+id: FPLX:000056
+name: ATG4
+synonym: "ATG4" EXACT []
+synonym: "Atg4" EXACT []
+xref: RE:R-HSA-5682664
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:16489 ! ATG4A
+relationship: inverse_is_a HGNC:20790 ! ATG4B
+relationship: inverse_is_a HGNC:16040 ! ATG4C
+relationship: inverse_is_a HGNC:20789 ! ATG4D
+
+[Term]
+id: FPLX:000057
+name: ATP1A
+synonym: "ATP1A" EXACT []
+synonym: "ATPase Na+/K+ transporting subunit alpha" EXACT []
+synonym: "ATPase Na+/K+ transporting subunit beta" EXACT []
+synonym: "ATPase Na+/K+ transporting subunit α" EXACT []
+synonym: "ATPase Na+/K+ transporting subunit β" EXACT []
+synonym: "Na/K ATPase alpha" EXACT []
+synonym: "Na/K ATPase α" EXACT []
+xref: RE:R-HSA-936779
+relationship: part_of FPLX:000303 ! Na_K_ATPase
+relationship: inverse_is_a HGNC:799 ! ATP1A1
+relationship: inverse_is_a HGNC:800 ! ATP1A2
+relationship: inverse_is_a HGNC:801 ! ATP1A3
+relationship: inverse_is_a HGNC:14073 ! ATP1A4
+
+[Term]
+id: FPLX:000058
+name: ATP1B
+synonym: "Na,K-ATPase beta subunit" EXACT []
+synonym: "Na,K-ATPase β subunit" EXACT []
+synonym: "ATP1B" EXACT []
+xref: RE:R-HSA-936820
+relationship: part_of FPLX:000303 ! Na_K_ATPase
+relationship: inverse_is_a HGNC:804 ! ATP1B1
+relationship: inverse_is_a HGNC:805 ! ATP1B2
+relationship: inverse_is_a HGNC:806 ! ATP1B3
+relationship: inverse_is_a HGNC:808 ! ATP1B4
+
+[Term]
+id: FPLX:000059
+name: ATP5G
+synonym: "ATP synthase H + transporting mitochondrial F0 complex subunit G" EXACT []
+xref: BEL:"ATP5G Family"
+xref: IP:IPR000454
+xref: IP:IPR020537
+relationship: part_of FPLX:000060 ! ATP_synthase
+relationship: inverse_is_a HGNC:841 ! ATP5MC1
+relationship: inverse_is_a HGNC:842 ! ATP5MC2
+relationship: inverse_is_a HGNC:843 ! ATP5MC3
+
+[Term]
+id: FPLX:000060
+name: ATP-synthase
+synonym: "ATP synthase" EXACT []
+xref: BEL:"Proton Transporting ATP Synthase Complex"
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:823 ! ATP5F1A
+relationship: has_part HGNC:830 ! ATP5F1B
+relationship: has_part HGNC:833 ! ATP5F1C
+relationship: has_part HGNC:837 ! ATP5F1D
+relationship: has_part HGNC:838 ! ATP5F1E
+relationship: has_part HGNC:30889 ! ATP5MD
+relationship: has_part HGNC:846 ! ATP5ME
+relationship: has_part HGNC:848 ! ATP5MF
+relationship: has_part HGNC:14247 ! ATP5MG
+relationship: has_part HGNC:1188 ! ATP5MPL
+relationship: has_part HGNC:7414 ! MT-ATP6
+relationship: has_part HGNC:7415 ! MT-ATP8
+relationship: has_part HGNC:840 ! ATP5PB
+relationship: has_part HGNC:845 ! ATP5PD
+relationship: has_part HGNC:847 ! ATP5PF
+relationship: has_part HGNC:850 ! ATP5PO
+relationship: has_part HGNC:871 ! ATP5IF1
+relationship: has_part FPLX:000059 ! ATP5G
+
+[Term]
+id: FPLX:000061
+name: Augmin
+synonym: "Augmin" EXACT []
+synonym: "HAUS" EXACT []
+synonym: "HAUS complex" EXACT []
+xref: GO:0070652
+xref: HGNC_GROUP:581
+xref: RE:R-HSA-8855211
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:25174 ! HAUS1
+relationship: has_part HGNC:25530 ! HAUS2
+relationship: has_part HGNC:28719 ! HAUS3
+relationship: has_part HGNC:20163 ! HAUS4
+relationship: has_part HGNC:29130 ! HAUS5
+relationship: has_part HGNC:25948 ! HAUS6
+relationship: has_part HGNC:32979 ! HAUS7
+relationship: has_part HGNC:30532 ! HAUS8
+
+[Term]
+id: FPLX:000062
+name: AXIN
+synonym: "Axin" EXACT []
+synonym: "hAxin" EXACT []
+xref: BEL:"AXIN Family"
+xref: IP:IPR014936
+xref: IP:IPR032101
+xref: RE:R-HSA-3640819
+xref: RE:R-HSA-3640863
+xref: RE:R-HSA-3772502
+xref: RE:R-HSA-4641132
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:903 ! AXIN1
+relationship: inverse_is_a HGNC:904 ! AXIN2
+
+[Term]
+id: FPLX:000063
+name: B3GAT
+synonym: "B3GAT" EXACT []
+synonym: "Beta-1,3-glucuronyltransferase" EXACT []
+synonym: "Beta-1,3-glucuronyltransferases" EXACT []
+synonym: "beta-1,3-glucuronyltransferase" EXACT []
+synonym: "beta-1,3-glucuronyltransferases" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:921 ! B3GAT1
+relationship: inverse_is_a HGNC:922 ! B3GAT2
+relationship: inverse_is_a HGNC:923 ! B3GAT3
+
+[Term]
+id: FPLX:000064
+name: BCKDC
+synonym: "BCKDC" EXACT []
+synonym: "BCKDH" EXACT []
+synonym: "branched-chain alpha-keto acid dehydrogenase complex" EXACT []
+synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT []
+synonym: "branched-chain α-keto acid dehydrogenase complex" EXACT []
+synonym: "branched-chain α-ketoacid dehydrogenase complex" EXACT []
+xref: BEL:"Branched Chain Alpha Keto Acid Dehydrogenase Complex"
+xref: RE:R-HSA-5693120
+xref: RE:R-HSA-6792583
+xref: RE:R-HSA-70019
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:986 ! BCKDHA
+relationship: has_part HGNC:987 ! BCKDHB
+relationship: has_part HGNC:2698 ! DBT
+relationship: has_part HGNC:2898 ! DLD
+
+[Term]
+id: FPLX:000065
+name: Beta-3-4-GTF
+synonym: "Beta 3-glycosyltransferase" EXACT []
+synonym: "Beta 3-glycosyltransferases" EXACT []
+synonym: "beta 3-glycosyltransferase" EXACT []
+synonym: "beta 3-glycosyltransferases" EXACT []
+synonym: "Beta 4-glycosyltransferase" EXACT []
+synonym: "Beta 4-glycosyltransferases" EXACT []
+synonym: "beta 4-glycosyltransferase" EXACT []
+synonym: "beta 4-glycosyltransferases" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:918 ! B3GALNT1
+relationship: inverse_is_a HGNC:28596 ! B3GALNT2
+relationship: inverse_is_a HGNC:20207 ! B3GLCT
+relationship: inverse_is_a HGNC:916 ! B3GALT1
+relationship: inverse_is_a HGNC:917 ! B3GALT2
+relationship: inverse_is_a HGNC:919 ! B3GALT4
+relationship: inverse_is_a HGNC:920 ! B3GALT5
+relationship: inverse_is_a HGNC:17978 ! B3GALT6
+relationship: inverse_is_a HGNC:15629 ! B3GNT2
+relationship: inverse_is_a HGNC:13528 ! B3GNT3
+relationship: inverse_is_a HGNC:15683 ! B3GNT4
+relationship: inverse_is_a HGNC:15684 ! B3GNT5
+relationship: inverse_is_a HGNC:24141 ! B3GNT6
+relationship: inverse_is_a HGNC:18811 ! B3GNT7
+relationship: inverse_is_a HGNC:24139 ! B3GNT8
+relationship: inverse_is_a HGNC:28714 ! B3GNT9
+relationship: inverse_is_a HGNC:24291 ! CHPF
+relationship: inverse_is_a HGNC:29270 ! CHPF2
+relationship: inverse_is_a HGNC:17198 ! CHSY1
+relationship: inverse_is_a HGNC:24293 ! CHSY3
+relationship: inverse_is_a HGNC:24337 ! C1GALT1
+relationship: inverse_is_a HGNC:6560 ! LFNG
+relationship: inverse_is_a HGNC:7038 ! MFNG
+relationship: inverse_is_a HGNC:9974 ! RFNG
+relationship: inverse_is_a HGNC:4117 ! B4GALNT1
+relationship: inverse_is_a HGNC:24136 ! B4GALNT2
+relationship: inverse_is_a HGNC:24137 ! B4GALNT3
+relationship: inverse_is_a HGNC:26315 ! B4GALNT4
+relationship: inverse_is_a HGNC:924 ! B4GALT1
+relationship: inverse_is_a HGNC:925 ! B4GALT2
+relationship: inverse_is_a HGNC:926 ! B4GALT3
+relationship: inverse_is_a HGNC:927 ! B4GALT4
+relationship: inverse_is_a HGNC:928 ! B4GALT5
+relationship: inverse_is_a HGNC:929 ! B4GALT6
+relationship: inverse_is_a HGNC:930 ! B4GALT7
+relationship: inverse_is_a HGNC:24290 ! CSGALNACT1
+relationship: inverse_is_a HGNC:24292 ! CSGALNACT2
+
+[Term]
+id: FPLX:000066
+name: BIRC
+synonym: "BIRs" EXACT []
+xref: BEL:"BIRC Family"
+xref: IP:IPR001370
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:590 ! BIRC2
+relationship: inverse_is_a HGNC:591 ! BIRC3
+relationship: inverse_is_a HGNC:593 ! BIRC5
+relationship: inverse_is_a HGNC:13516 ! BIRC6
+relationship: inverse_is_a HGNC:13702 ! BIRC7
+relationship: inverse_is_a HGNC:14878 ! BIRC8
+relationship: inverse_is_a HGNC:7634 ! NAIP
+relationship: inverse_is_a HGNC:592 ! XIAP
+
+[Term]
+id: FPLX:000067
+name: BMP
+synonym: "BMP" EXACT []
+xref: BEL:"BMP Family"
+xref: NCIT:C17274
+xref: XFAM:PF02608
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1067 ! BMP1
+relationship: inverse_is_a HGNC:1069 ! BMP2
+relationship: inverse_is_a HGNC:1070 ! BMP3
+relationship: inverse_is_a HGNC:1071 ! BMP4
+relationship: inverse_is_a HGNC:1072 ! BMP5
+relationship: inverse_is_a HGNC:1073 ! BMP6
+relationship: inverse_is_a HGNC:1074 ! BMP7
+relationship: inverse_is_a HGNC:21650 ! BMP8A
+relationship: inverse_is_a HGNC:1075 ! BMP8B
+relationship: inverse_is_a HGNC:20869 ! BMP10
+relationship: inverse_is_a HGNC:1068 ! BMP15
+relationship: inverse_is_a HGNC:4214 ! GDF1
+relationship: inverse_is_a HGNC:4217 ! GDF2
+relationship: inverse_is_a HGNC:4218 ! GDF3
+relationship: inverse_is_a HGNC:4220 ! GDF5
+relationship: inverse_is_a HGNC:4221 ! GDF6
+relationship: inverse_is_a HGNC:4222 ! GDF7
+
+[Term]
+id: FPLX:000068
+name: BMP-receptor
+xref: SIGNOR:SIGNOR-PF9
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000069 ! BMP_receptor_type_I
+relationship: inverse_is_a FPLX:000070 ! BMP_receptor_type_II
+
+[Term]
+id: FPLX:000069
+name: BMP-receptor-type-I
+synonym: "BMP Receptor Type I" EXACT []
+synonym: "BMP type I receptor" EXACT []
+synonym: "bone morphogenetic protein I receptor" EXACT []
+synonym: "bone morphogenetic protein receptor 1" EXACT []
+synonym: "bone morphogenetic protein receptor type I" EXACT []
+synonym: "bone morphogenetic protein type I receptors" EXACT []
+synonym: "BRI" EXACT []
+xref: BEL:"BMP Receptor Type I Family"
+xref: MEDSCAN:urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor
+is_a: FPLX:000068 ! BMP_receptor
+relationship: inverse_is_a HGNC:171 ! ACVR1
+relationship: inverse_is_a HGNC:1076 ! BMPR1A
+relationship: inverse_is_a HGNC:1077 ! BMPR1B
+
+[Term]
+id: FPLX:000070
+name: BMP-receptor-type-II
+synonym: "BMP Receptor Type II" EXACT []
+synonym: "BMP type II receptor" EXACT []
+synonym: "bone morphogenetic protein receptor 2" EXACT []
+synonym: "bone morphogenetic protein receptor type II" EXACT []
+synonym: "bone morphogenetic protein type II receptors" EXACT []
+synonym: "BRII" EXACT []
+xref: BEL:"BMP Receptor Type II Family"
+xref: RE:R-HSA-201465
+xref: RE:R-HSA-201804
+is_a: FPLX:000068 ! BMP_receptor
+relationship: inverse_is_a HGNC:173 ! ACVR2A
+relationship: inverse_is_a HGNC:174 ! ACVR2B
+relationship: inverse_is_a HGNC:1078 ! BMPR2
+
+[Term]
+id: FPLX:000071
+name: BRCA
+synonym: "BRCA" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1100 ! BRCA1
+relationship: inverse_is_a HGNC:1101 ! BRCA2
+
+[Term]
+id: FPLX:000072
+name: C1
+synonym: "c1 complex" EXACT []
+synonym: "C1" EXACT []
+synonym: "C1-complex" EXACT []
+xref: BEL:"C1 Complex"
+xref: RE:R-HSA-173584
+xref: RE:R-HSA-173615
+xref: RE:R-HSA-173617
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1241 ! C1QA
+relationship: has_part HGNC:1242 ! C1QB
+relationship: has_part HGNC:1245 ! C1QC
+relationship: has_part HGNC:1246 ! C1R
+relationship: has_part HGNC:1247 ! C1S
+
+[Term]
+id: FPLX:000073
+name: C1q
+synonym: "C1q" EXACT []
+xref: BEL:"C1q Complex"
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1241 ! C1QA
+relationship: has_part HGNC:1242 ! C1QB
+
+[Term]
+id: FPLX:000074
+name: Cadherin
+synonym: "cadherin" EXACT []
+xref: BEL:"CDH Family"
+xref: MEDSCAN:urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896
+xref: MEDSCAN:urn:agi-protfc:cadherin
+xref: NCIT:C16373
+xref: XFAM:PF00028
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1748 ! CDH1
+relationship: inverse_is_a HGNC:1749 ! CDH10
+relationship: inverse_is_a HGNC:1750 ! CDH11
+relationship: inverse_is_a HGNC:1751 ! CDH12
+relationship: inverse_is_a HGNC:1753 ! CDH13
+relationship: inverse_is_a HGNC:1754 ! CDH15
+relationship: inverse_is_a HGNC:1755 ! CDH16
+relationship: inverse_is_a HGNC:1756 ! CDH17
+relationship: inverse_is_a HGNC:1757 ! CDH18
+relationship: inverse_is_a HGNC:1758 ! CDH19
+relationship: inverse_is_a HGNC:1759 ! CDH2
+relationship: inverse_is_a HGNC:1760 ! CDH20
+relationship: inverse_is_a HGNC:13251 ! CDH22
+relationship: inverse_is_a HGNC:14265 ! CDH24
+relationship: inverse_is_a HGNC:1762 ! CDH3
+relationship: inverse_is_a HGNC:1763 ! CDH4
+relationship: inverse_is_a HGNC:1764 ! CDH5
+relationship: inverse_is_a HGNC:1765 ! CDH6
+relationship: inverse_is_a HGNC:1766 ! CDH7
+relationship: inverse_is_a HGNC:1767 ! CDH8
+relationship: inverse_is_a HGNC:1768 ! CDH9
+
+[Term]
+id: FPLX:000075
+name: CALM
+synonym: "Calmodulin" EXACT []
+synonym: "calmodulin" EXACT []
+synonym: "CaM" EXACT []
+xref: BEL:"CALM Family"
+xref: MEDSCAN:urn:agi-aopfc:0000452
+xref: MEDSCAN:urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11
+xref: NCIT:C16375
+xref: NEXTPROT-FAMILY:00440
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1442 ! CALM1
+relationship: inverse_is_a HGNC:1445 ! CALM2
+relationship: inverse_is_a HGNC:1449 ! CALM3
+
+[Term]
+id: FPLX:000076
+name: CAMK
+synonym: "CaMK family" EXACT []
+synonym: "CaMK" EXACT []
+xref: BEL:"CAMK Family"
+xref: ECCODE:2.7.11.17
+xref: NEXTPROT-FAMILY:03072
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1459 ! CAMK1
+relationship: inverse_is_a HGNC:19341 ! CAMK1D
+relationship: inverse_is_a HGNC:14585 ! CAMK1G
+relationship: inverse_is_a HGNC:1464 ! CAMK4
+relationship: inverse_is_a FPLX:000078 ! CAMK2_family
+
+[Term]
+id: FPLX:000077
+name: CAMK2-complex
+synonym: "Ca(2+)-calmodulin-dependent protein kinase II" EXACT []
+synonym: "Ca(2+)/calmodulin-dependent kinase II" EXACT []
+synonym: "CaM kinase II" EXACT []
+synonym: "CaMK II" EXACT []
+synonym: "CaMKII" EXACT []
+xref: BEL:"CAMK2 Complex"
+xref: IP:IPR013543
+xref: MEDSCAN:urn:agi-complex:CaM%20kinase%20II
+xref: RE:R-HSA-417004
+xref: RE:R-HSA-432792
+xref: RE:R-HSA-444796
+xref: RE:R-HSA-445374
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1460 ! CAMK2A
+relationship: has_part HGNC:1461 ! CAMK2B
+relationship: has_part HGNC:1462 ! CAMK2D
+relationship: has_part HGNC:1463 ! CAMK2G
+
+[Term]
+id: FPLX:000078
+name: CAMK2-family
+synonym: "calmodulindependent kinase II" EXACT []
+synonym: "CAMK2" EXACT []
+synonym: "CaMK2" EXACT []
+synonym: "CAMKII" EXACT []
+xref: BEL:"CAMK2 Family"
+xref: IP:IPR013543
+xref: RE:R-HSA-417004
+xref: RE:R-HSA-432792
+xref: RE:R-HSA-444796
+xref: RE:R-HSA-445374
+is_a: FPLX:000076 ! CAMK
+relationship: inverse_is_a HGNC:1460 ! CAMK2A
+relationship: inverse_is_a HGNC:1461 ! CAMK2B
+relationship: inverse_is_a HGNC:1462 ! CAMK2D
+relationship: inverse_is_a HGNC:1463 ! CAMK2G
+
+[Term]
+id: FPLX:000079
+name: CAPN
+synonym: "calpain" EXACT []
+xref: BEL:"CAPN Family"
+xref: GO:0004198
+xref: IP:IPR022684
+xref: NCIT:C16377
+xref: RE:R-HSA-8848649
+xref: RE:R-HSA-8848668
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1476 ! CAPN1
+relationship: inverse_is_a HGNC:1477 ! CAPN10
+relationship: inverse_is_a HGNC:1478 ! CAPN11
+relationship: inverse_is_a HGNC:13249 ! CAPN12
+relationship: inverse_is_a HGNC:16663 ! CAPN13
+relationship: inverse_is_a HGNC:16664 ! CAPN14
+relationship: inverse_is_a HGNC:1479 ! CAPN2
+relationship: inverse_is_a HGNC:1480 ! CAPN3
+relationship: inverse_is_a HGNC:1482 ! CAPN5
+relationship: inverse_is_a HGNC:1483 ! CAPN6
+relationship: inverse_is_a HGNC:1484 ! CAPN7
+relationship: inverse_is_a HGNC:1486 ! CAPN9
+relationship: inverse_is_a HGNC:11182 ! CAPN15
+relationship: inverse_is_a HGNC:1485 ! CAPN8
+
+[Term]
+id: FPLX:000080
+name: Carboxylesterase
+synonym: "carboxylesterase" EXACT []
+synonym: "carboxylesterases" EXACT []
+xref: BEL:"Carboxylesterase Family"
+xref: ECCODE:3.1.1.1
+xref: NCIT:C112051
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1863 ! CES1
+relationship: inverse_is_a HGNC:1864 ! CES2
+relationship: inverse_is_a HGNC:1865 ! CES3
+relationship: inverse_is_a HGNC:26741 ! CES4A
+relationship: inverse_is_a HGNC:26459 ! CES5A
+
+[Term]
+id: FPLX:000081
+name: Caspase
+synonym: "caspase" EXACT []
+synonym: "caspases" EXACT []
+xref: BEL:"CASP Family"
+xref: GO:0004199
+xref: IP:IPR002138
+xref: IP:IPR033139
+xref: MESH:D020169
+xref: NCIT:C18153
+xref: XFAM:PF00656
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1499 ! CASP1
+relationship: inverse_is_a HGNC:1503 ! CASP2
+relationship: inverse_is_a HGNC:1505 ! CASP4
+relationship: inverse_is_a HGNC:1506 ! CASP5
+relationship: inverse_is_a HGNC:1507 ! CASP6
+relationship: inverse_is_a HGNC:1509 ! CASP8
+relationship: inverse_is_a HGNC:1511 ! CASP9
+relationship: inverse_is_a HGNC:1500 ! CASP10
+relationship: inverse_is_a HGNC:19004 ! CASP12
+relationship: inverse_is_a HGNC:1502 ! CASP14
+relationship: inverse_is_a FPLX:000082 ! Caspase_3_7
+
+[Term]
+id: FPLX:000082
+name: Caspase-3-7
+synonym: "caspase-3/7" EXACT []
+xref: RE:R-HSA-202877
+is_a: FPLX:000081 ! Caspase
+relationship: inverse_is_a HGNC:1504 ! CASP3
+relationship: inverse_is_a HGNC:1508 ! CASP7
+
+[Term]
+id: FPLX:000083
+name: CAV
+synonym: "Caveolin" EXACT []
+synonym: "caveolin" EXACT []
+xref: BEL:"CAV Family"
+xref: IP:IPR001612
+xref: IP:IPR018361
+xref: MEDSCAN:urn:agi-protfc:caveolin
+xref: NEXTPROT-FAMILY:00489
+xref: XFAM:PF01146
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1527 ! CAV1
+relationship: inverse_is_a HGNC:1528 ! CAV2
+relationship: inverse_is_a HGNC:1529 ! CAV3
+
+[Term]
+id: FPLX:000084
+name: CBF3
+def: "SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex" [interpro:IPR016072]
+synonym: "CBF3 complex" EXACT []
+synonym: "CBF3" EXACT []
+synonym: "kinetochore centromere binding factor 3" EXACT []
+xref: BEL:"CBF3 Complex"
+xref: GO:0031518
+xref: IP:IPR016072
+xref: IP:IPR016897
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:10899 ! SKP1
+
+[Term]
+id: FPLX:000085
+name: CCT-complex
+synonym: "CCT complex" EXACT []
+synonym: "CCT" EXACT []
+synonym: "chaperonin containing TCP-1" EXACT []
+synonym: "chaperonin" EXACT []
+synonym: "chaperonin-containing t-complex polypeptide 1" EXACT []
+synonym: "chaperonin-containing TCP1 complex" EXACT []
+synonym: "TRiC" EXACT []
+xref: BEL:"CCT Complex"
+xref: GO:0005832
+xref: IP:IPR002194
+xref: MEDSCAN:urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61
+xref: RE:R-HSA-390455
+xref: RE:R-HSA-390474
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1615 ! CCT2
+relationship: has_part HGNC:1616 ! CCT3
+relationship: has_part HGNC:1617 ! CCT4
+relationship: has_part HGNC:1618 ! CCT5
+relationship: has_part HGNC:1620 ! CCT6A
+relationship: has_part HGNC:1621 ! CCT6B
+relationship: has_part HGNC:1622 ! CCT7
+relationship: has_part HGNC:1623 ! CCT8
+relationship: has_part HGNC:11655 ! TCP1
+
+[Term]
+id: FPLX:000086
+name: CD16
+synonym: "CD16" EXACT []
+xref: BEL:"CD16 Family"
+xref: NCIT:C17487
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3619 ! FCGR3A
+relationship: inverse_is_a HGNC:3620 ! FCGR3B
+
+[Term]
+id: FPLX:000087
+name: CD3
+synonym: "CD3" EXACT []
+xref: BEL:"CD3 Complex"
+xref: MEDSCAN:urn:agi-complex:CD3%20complex
+xref: NCIT:C38897
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1677 ! CD247
+relationship: has_part HGNC:1673 ! CD3D
+relationship: has_part HGNC:1674 ! CD3E
+relationship: has_part HGNC:1675 ! CD3G
+
+[Term]
+id: FPLX:000088
+name: CD32
+synonym: "CD32" EXACT []
+xref: BEL:"CD32 Family"
+xref: NCIT:C18308
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3616 ! FCGR2A
+relationship: inverse_is_a HGNC:3618 ! FCGR2B
+relationship: inverse_is_a HGNC:15626 ! FCGR2C
+
+[Term]
+id: FPLX:000089
+name: CD64
+synonym: "CD64" EXACT []
+xref: BEL:"CD64 Family"
+xref: RE:R-HSA-1031694
+xref: RE:R-HSA-1236898
+xref: RE:R-HSA-1236905
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3613 ! FCGR1A
+relationship: inverse_is_a HGNC:3614 ! FCGR1B
+
+[Term]
+id: FPLX:000090
+name: CD8
+synonym: "CD8" EXACT []
+xref: MEDSCAN:urn:agi-complex:CD8
+xref: RE:R-HSA-198899
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1706 ! CD8A
+relationship: inverse_is_a HGNC:1707 ! CD8B
+
+[Term]
+id: FPLX:000091
+name: CDC25
+synonym: "CDC25 family" EXACT []
+synonym: "Cdc25 phosphatases" EXACT []
+synonym: "CDC25" EXACT []
+synonym: "Cdc25" EXACT []
+xref: BEL:"CDC25 Family"
+xref: IP:IPR000751
+xref: MEDSCAN:urn:agi-aopfc:0000551
+xref: RE:R-HSA-170108
+xref: RE:R-HSA-69261
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1725 ! CDC25A
+relationship: inverse_is_a HGNC:1726 ! CDC25B
+relationship: inverse_is_a HGNC:1727 ! CDC25C
+
+[Term]
+id: FPLX:000092
+name: CDK
+synonym: "CDK" EXACT []
+synonym: "Cdk" EXACT []
+synonym: "CDKs" EXACT []
+xref: ECCODE:2.7.11.22
+xref: MEDSCAN:urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee
+xref: MESH:D018844
+xref: NCIT:C17767
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1781 ! CDKL1
+relationship: inverse_is_a HGNC:1782 ! CDKL2
+relationship: inverse_is_a HGNC:15483 ! CDKL3
+relationship: inverse_is_a HGNC:19287 ! CDKL4
+relationship: inverse_is_a HGNC:11411 ! CDKL5
+relationship: inverse_is_a FPLX:000093 ! CDK1_2
+relationship: inverse_is_a HGNC:1772 ! CDK3
+relationship: inverse_is_a HGNC:1773 ! CDK4
+relationship: inverse_is_a HGNC:1774 ! CDK5
+relationship: inverse_is_a HGNC:1777 ! CDK6
+relationship: inverse_is_a HGNC:1778 ! CDK7
+relationship: inverse_is_a HGNC:1779 ! CDK8
+relationship: inverse_is_a HGNC:1780 ! CDK9
+relationship: inverse_is_a HGNC:1770 ! CDK10
+relationship: inverse_is_a HGNC:1730 ! CDK11A
+relationship: inverse_is_a HGNC:1729 ! CDK11B
+relationship: inverse_is_a HGNC:24224 ! CDK12
+relationship: inverse_is_a HGNC:1733 ! CDK13
+relationship: inverse_is_a HGNC:8883 ! CDK14
+relationship: inverse_is_a HGNC:14434 ! CDK15
+relationship: inverse_is_a HGNC:8749 ! CDK16
+relationship: inverse_is_a HGNC:8750 ! CDK17
+relationship: inverse_is_a HGNC:8751 ! CDK18
+relationship: inverse_is_a HGNC:19338 ! CDK19
+relationship: inverse_is_a HGNC:21420 ! CDK20
+
+[Term]
+id: FPLX:000093
+name: CDK1-2
+synonym: "CDK1/2" EXACT []
+synonym: "cdk1/2" EXACT []
+synonym: "Cdk1/2" EXACT []
+is_a: FPLX:000092 ! CDK
+relationship: inverse_is_a HGNC:1722 ! CDK1
+relationship: inverse_is_a HGNC:1771 ! CDK2
+
+[Term]
+id: FPLX:000094
+name: CDKN
+synonym: "CDKN" EXACT []
+synonym: "CKI" EXACT []
+synonym: "cyclin dependent kinase inhibitors" EXACT []
+synonym: "cyclin-dependent kinase inhibitor" EXACT []
+synonym: "cyclin-dependent protein kinase inhibitors" EXACT []
+xref: NCIT:C18492
+xref: XFAM:PF02234
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000095 ! CDKN1
+relationship: inverse_is_a FPLX:000096 ! CDKN2
+relationship: inverse_is_a HGNC:1791 ! CDKN3
+
+[Term]
+id: FPLX:000095
+name: CDKN1
+synonym: "CDKN1" EXACT []
+xref: IP:IPR003175
+xref: RE:R-HSA-8941923
+xref: RE:R-HSA-8942604
+xref: RE:R-HSA-8948131
+is_a: FPLX:000094 ! CDKN
+relationship: inverse_is_a HGNC:1784 ! CDKN1A
+relationship: inverse_is_a HGNC:1785 ! CDKN1B
+relationship: inverse_is_a HGNC:1786 ! CDKN1C
+
+[Term]
+id: FPLX:000096
+name: CDKN2
+synonym: "CDKN2" EXACT []
+is_a: FPLX:000094 ! CDKN
+relationship: inverse_is_a HGNC:1787 ! CDKN2A
+relationship: inverse_is_a HGNC:1788 ! CDKN2B
+relationship: inverse_is_a HGNC:1789 ! CDKN2C
+relationship: inverse_is_a HGNC:1790 ! CDKN2D
+
+[Term]
+id: FPLX:000097
+name: CEBP
+synonym: "C/EBP" EXACT []
+synonym: "CCAAT/enhancer binding protein" EXACT []
+xref: BEL:"CEBP Family"
+xref: NEXTPROT-FAMILY:00406
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1833 ! CEBPA
+relationship: inverse_is_a HGNC:1834 ! CEBPB
+relationship: inverse_is_a HGNC:1835 ! CEBPD
+relationship: inverse_is_a HGNC:1837 ! CEBPG
+relationship: inverse_is_a HGNC:1836 ! CEBPE
+
+[Term]
+id: FPLX:000098
+name: CHEK
+synonym: "checkpoint kinase" EXACT []
+synonym: "Chk1/2" EXACT []
+xref: MEDSCAN:urn:agi-protfc:checkpoint%20kinase
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1925 ! CHEK1
+relationship: inverse_is_a HGNC:16627 ! CHEK2
+
+[Term]
+id: FPLX:000099
+name: Chemokine
+synonym: "chemokine" EXACT []
+synonym: "chemokines" EXACT []
+xref: MEDSCAN:urn:agi-aopfc:0000391
+xref: NCIT:C20466
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000128 ! CXCL_ELR_negative
+relationship: inverse_is_a FPLX:000129 ! CXCL_ELR_positive
+
+[Term]
+id: FPLX:000100
+name: Chemokine-receptor
+synonym: "chemoattractant receptor" EXACT []
+xref: BEL:"Chemokine Receptor Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1565 ! ACKR2
+relationship: inverse_is_a HGNC:1602 ! CCR1
+relationship: inverse_is_a HGNC:4474 ! CCR10
+relationship: inverse_is_a HGNC:1603 ! CCR2
+relationship: inverse_is_a HGNC:1604 ! CCR3
+relationship: inverse_is_a HGNC:1605 ! CCR4
+relationship: inverse_is_a HGNC:1606 ! CCR5
+relationship: inverse_is_a HGNC:1607 ! CCR6
+relationship: inverse_is_a HGNC:1608 ! CCR7
+relationship: inverse_is_a HGNC:1609 ! CCR8
+relationship: inverse_is_a HGNC:1610 ! CCR9
+relationship: inverse_is_a HGNC:1611 ! ACKR4
+relationship: inverse_is_a HGNC:1612 ! CCRL2
+relationship: inverse_is_a HGNC:2558 ! CX3CR1
+relationship: inverse_is_a HGNC:6026 ! CXCR1
+relationship: inverse_is_a HGNC:6027 ! CXCR2
+relationship: inverse_is_a HGNC:4540 ! CXCR3
+relationship: inverse_is_a HGNC:2561 ! CXCR4
+relationship: inverse_is_a HGNC:1060 ! CXCR5
+relationship: inverse_is_a HGNC:16647 ! CXCR6
+relationship: inverse_is_a HGNC:23692 ! ACKR3
+relationship: inverse_is_a HGNC:1625 ! XCR1
+
+[Term]
+id: FPLX:000101
+name: Cholinesterase
+synonym: "choline esterase" EXACT []
+synonym: "cholinesterase" EXACT []
+xref: BEL:"Cholinesterase Family"
+xref: IP:IPR000997
+xref: IP:IPR014788
+xref: RE:R-HSA-2990868
+xref: RE:R-HSA-3640837
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:108 ! ACHE
+relationship: inverse_is_a HGNC:983 ! BCHE
+
+[Term]
+id: FPLX:000102
+name: CHRM
+synonym: "acetylcholine receptor" EXACT []
+xref: BEL:"CHRM Family"
+xref: IP:IPR000995
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1950 ! CHRM1
+relationship: inverse_is_a HGNC:1951 ! CHRM2
+relationship: inverse_is_a HGNC:1952 ! CHRM3
+relationship: inverse_is_a HGNC:1953 ! CHRM4
+relationship: inverse_is_a HGNC:1954 ! CHRM5
+
+[Term]
+id: FPLX:000103
+name: CHRN
+synonym: "nAChR" EXACT []
+synonym: "nicotine class acetylcholine receptors" EXACT []
+synonym: "nicotinic acetylcholine receptor" EXACT []
+xref: BEL:"CHRN Complex"
+xref: GO:0016904
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1956 ! CHRNA2
+relationship: has_part HGNC:1957 ! CHRNA3
+relationship: has_part HGNC:1958 ! CHRNA4
+relationship: has_part HGNC:1959 ! CHRNA5
+relationship: has_part HGNC:15963 ! CHRNA6
+relationship: has_part HGNC:1960 ! CHRNA7
+relationship: has_part HGNC:1962 ! CHRNB2
+relationship: has_part HGNC:1963 ! CHRNB3
+relationship: has_part HGNC:1964 ! CHRNB4
+
+[Term]
+id: FPLX:000104
+name: CK2
+synonym: "casein kinase 2" EXACT []
+synonym: "casein kinase II complex" EXACT []
+synonym: "casein kinase II" EXACT []
+synonym: "CK2" EXACT []
+xref: BEL:"CK II Complex"
+xref: GO:0005956
+xref: NCIT:C107559
+xref: NEXTPROT-FAMILY:03101
+xref: RE:R-HSA-201711
+xref: RE:R-HSA-6805066
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2457 ! CSNK2A1
+relationship: has_part HGNC:2459 ! CSNK2A2
+relationship: has_part HGNC:2460 ! CSNK2B
+
+[Term]
+id: FPLX:000105
+name: Clathrin
+synonym: "clathrin coat" EXACT []
+synonym: "clathrin" EXACT []
+xref: BEL:"Clathrin Complex"
+xref: GO:0016190
+xref: RE:R-HSA-5138439
+xref: RE:R-HSA-5138447
+xref: RE:R-HSA-5333713
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2090 ! CLTA
+relationship: has_part HGNC:2091 ! CLTB
+relationship: has_part HGNC:2092 ! CLTC
+
+[Term]
+id: FPLX:000106
+name: CNKSR
+synonym: "CNKSR" EXACT []
+synonym: "connector enhancer of kinase suppressor of ras" EXACT []
+xref: NEXTPROT-FAMILY:00653
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:19700 ! CNKSR1
+relationship: inverse_is_a HGNC:19701 ! CNKSR2
+
+[Term]
+id: FPLX:000107
+name: Cofilin
+synonym: "cofilin" EXACT []
+xref: IP:IPR017904
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1874 ! CFL1
+relationship: inverse_is_a HGNC:1875 ! CFL2
+relationship: inverse_is_a HGNC:15750 ! DSTN
+
+[Term]
+id: FPLX:000108
+name: Cohesin
+synonym: "cohesin complex" EXACT []
+synonym: "cohesin" EXACT []
+xref: BEL:"Cohesin Complex"
+xref: GO:0008278
+xref: GO:0008279
+xref: XFAM:PF00963
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9811 ! RAD21
+relationship: has_part HGNC:2468 ! SMC3
+
+[Term]
+id: FPLX:000109
+name: COL1
+synonym: "collagen type I" EXACT []
+synonym: "Type I collagen" EXACT []
+synonym: "type I collagen" EXACT []
+xref: BEL:"COL1 Family"
+xref: GO:0005584
+xref: NCIT:C124129
+xref: RE:R-HSA-2089970
+xref: RE:R-HSA-2396039
+xref: RE:R-HSA-2396161
+xref: RE:R-HSA-2396179
+xref: RE:R-HSA-2396183
+xref: RE:R-HSA-2396256
+xref: RE:R-HSA-2396260
+xref: RE:R-HSA-2396334
+xref: RE:R-HSA-2396451
+xref: RE:R-HSA-2396456
+xref: RE:R-HSA-2396478
+xref: RE:R-HSA-2399520
+xref: RE:R-HSA-2428941
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2197 ! COL1A1
+relationship: inverse_is_a HGNC:2198 ! COL1A2
+
+[Term]
+id: FPLX:000110
+name: COL4
+synonym: "Col4" EXACT []
+synonym: "ColIV" EXACT []
+synonym: "collagen IV" EXACT []
+synonym: "Collagen Type IV" EXACT []
+synonym: "collagen type IV" EXACT []
+xref: BEL:"COL4 Family"
+xref: GO:0005587
+xref: IP:IPR001442
+xref: NCIT:C16448
+xref: RE:R-HSA-2127389
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2202 ! COL4A1
+relationship: inverse_is_a HGNC:2203 ! COL4A2
+relationship: inverse_is_a HGNC:2204 ! COL4A3
+relationship: inverse_is_a HGNC:2206 ! COL4A4
+relationship: inverse_is_a HGNC:2207 ! COL4A5
+relationship: inverse_is_a HGNC:2208 ! COL4A6
+
+[Term]
+id: FPLX:000111
+name: COL5
+synonym: "collagen type V" EXACT []
+synonym: "type V collagen" EXACT []
+synonym: "type-V collagen" EXACT []
+xref: BEL:"COL5 Family"
+xref: GO:0005588
+xref: RE:R-HSA-2127310
+xref: RE:R-HSA-2127422
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2209 ! COL5A1
+relationship: inverse_is_a HGNC:2210 ! COL5A2
+relationship: inverse_is_a HGNC:14864 ! COL5A3
+
+[Term]
+id: FPLX:000112
+name: COLGALT
+synonym: "COLGALT" EXACT []
+synonym: "Collagen beta(1-O)galactosyltransferase" EXACT []
+synonym: "Collagen beta(1-O)galactosyltransferases" EXACT []
+synonym: "collagen beta(1-O)galactosyltransferase" EXACT []
+synonym: "collagen beta(1-O)galactosyltransferases" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:26182 ! COLGALT1
+relationship: inverse_is_a HGNC:16790 ! COLGALT2
+
+[Term]
+id: FPLX:000113
+name: COX
+synonym: "Complex IV" EXACT []
+synonym: "cytochrome c oxidase" EXACT []
+xref: BEL:"Cytochrome C Oxidase Complex Muscle"
+xref: BEL:"Cytochrome C Oxidase Complex Non Muscle"
+xref: ECCODE:1.9.3.1
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2267 ! COX5A
+relationship: has_part HGNC:2269 ! COX5B
+relationship: has_part FPLX:000114 ! COX4
+relationship: has_part FPLX:000115 ! COX6A
+relationship: has_part FPLX:000116 ! COX6B
+relationship: has_part FPLX:000117 ! COX7A
+relationship: has_part FPLX:000118 ! COX7B
+relationship: has_part FPLX:000119 ! COX8
+relationship: has_part HGNC:2260 ! COX10
+relationship: has_part HGNC:2261 ! COX11
+relationship: has_part HGNC:2263 ! COX15
+relationship: has_part HGNC:2264 ! COX17
+
+[Term]
+id: FPLX:000114
+name: COX4
+synonym: "Cox4" EXACT []
+xref: BEL:"COX4 Family"
+xref: IP:IPR004203
+xref: IP:IPR013288
+xref: XFAM:PF02936
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2265 ! COX4I1
+relationship: inverse_is_a HGNC:16232 ! COX4I2
+
+[Term]
+id: FPLX:000115
+name: COX6A
+synonym: "COX6A" EXACT []
+synonym: "Cox6a" EXACT []
+synonym: "Cytochrome c oxidase subunit 6a" EXACT []
+xref: BEL:"COX6A Family"
+xref: IP:IPR001349
+xref: IP:IPR018507
+xref: XFAM:PF02046
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2277 ! COX6A1
+relationship: inverse_is_a HGNC:2279 ! COX6A2
+
+[Term]
+id: FPLX:000116
+name: COX6B
+synonym: "Cox6b" EXACT []
+xref: BEL:"COX6B Family"
+xref: XFAM:PF02297
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2280 ! COX6B1
+relationship: inverse_is_a HGNC:24380 ! COX6B2
+
+[Term]
+id: FPLX:000117
+name: COX7A
+synonym: "COX7A" EXACT []
+synonym: "Cox7a" EXACT []
+xref: BEL:"COX7A Family"
+xref: XFAM:PF02238
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2287 ! COX7A1
+relationship: inverse_is_a HGNC:2288 ! COX7A2
+
+[Term]
+id: FPLX:000118
+name: COX7B
+synonym: "Cox7b" EXACT []
+xref: BEL:"COX7B Family"
+xref: IP:IPR008433
+xref: IP:IPR023272
+xref: XFAM:PF05392
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2291 ! COX7B
+relationship: inverse_is_a HGNC:24381 ! COX7B2
+
+[Term]
+id: FPLX:000119
+name: COX8
+synonym: "Cox8" EXACT []
+synonym: "cytochrome c oxidase subunit VIII" EXACT []
+xref: BEL:"COX8 Family"
+xref: IP:IPR003205
+xref: XFAM:PF02285
+relationship: part_of FPLX:000113 ! COX
+relationship: inverse_is_a HGNC:2294 ! COX8A
+relationship: inverse_is_a HGNC:24382 ! COX8C
+
+[Term]
+id: FPLX:000120
+name: CREB
+synonym: "CREB family" EXACT []
+synonym: "CREB" EXACT []
+xref: BEL:"CREB Family"
+xref: MEDSCAN:urn:agi-aopfc:0000094
+xref: NCIT:C17286
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2345 ! CREB1
+relationship: inverse_is_a HGNC:2347 ! CREB3
+relationship: inverse_is_a HGNC:16844 ! CREB5
+relationship: inverse_is_a HGNC:18856 ! CREB3L1
+relationship: inverse_is_a HGNC:23720 ! CREB3L2
+relationship: inverse_is_a HGNC:18855 ! CREB3L3
+relationship: inverse_is_a HGNC:18854 ! CREB3L4
+relationship: inverse_is_a HGNC:2352 ! CREM
+relationship: inverse_is_a HGNC:783 ! ATF1
+relationship: inverse_is_a HGNC:784 ! ATF2
+
+[Term]
+id: FPLX:000121
+name: CRISP
+synonym: "CRISP" EXACT []
+synonym: "CRISPs" EXACT []
+synonym: "cysteine rich secretory proteins" EXACT []
+synonym: "cysteine-rich secretory proteins" EXACT []
+xref: BEL:"CRISP Family"
+xref: IP:IPR013871
+xref: IP:IPR034117
+xref: XFAM:PF08562
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:304 ! CRISP1
+relationship: inverse_is_a HGNC:12024 ! CRISP2
+relationship: inverse_is_a HGNC:16904 ! CRISP3
+
+[Term]
+id: FPLX:000122
+name: CRSP
+synonym: "CRSP complex" EXACT []
+synonym: "CRSP" EXACT []
+synonym: "CRSP/Med complex" EXACT []
+synonym: "transcriptional cofactor complex CRSP" EXACT []
+xref: BEL:"CRSP Complex"
+xref: NCIT:C28687
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9234 ! MED1
+relationship: has_part HGNC:2370 ! MED14
+relationship: has_part HGNC:2375 ! MED17
+relationship: has_part HGNC:2372 ! MED23
+relationship: has_part HGNC:2376 ! MED26
+relationship: has_part HGNC:2377 ! MED27
+relationship: has_part HGNC:2378 ! MED7
+
+[Term]
+id: FPLX:000123
+name: CRTC
+synonym: "CRTC" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:16062 ! CRTC1
+relationship: inverse_is_a HGNC:27301 ! CRTC2
+relationship: inverse_is_a HGNC:26148 ! CRTC3
+
+[Term]
+id: FPLX:000124
+name: CSNK1
+synonym: "Casein kinase 1" EXACT []
+synonym: "casein kinase 1" EXACT []
+synonym: "casein kinase I" EXACT []
+synonym: "CSNK1" EXACT []
+xref: BEL:"CSNK1 Family"
+xref: MEDSCAN:urn:agi-protfc:casein%20kinase%20I
+xref: NEXTPROT-FAMILY:03083
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2451 ! CSNK1A1
+relationship: inverse_is_a HGNC:20289 ! CSNK1A1L
+relationship: inverse_is_a HGNC:2452 ! CSNK1D
+relationship: inverse_is_a HGNC:2453 ! CSNK1E
+relationship: inverse_is_a HGNC:2454 ! CSNK1G1
+relationship: inverse_is_a HGNC:2455 ! CSNK1G2
+relationship: inverse_is_a HGNC:2456 ! CSNK1G3
+
+[Term]
+id: FPLX:000125
+name: CSNK2
+synonym: "CSNK2" EXACT []
+xref: BEL:"CSNK2 Family"
+xref: RE:R-HSA-5083623
+xref: RE:R-HSA-5083624
+xref: RE:R-HSA-6805064
+xref: RE:R-HSA-6805073
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2457 ! CSNK2A1
+relationship: inverse_is_a HGNC:2459 ! CSNK2A2
+
+[Term]
+id: FPLX:000126
+name: CTNNA
+synonym: "a-cathenin" EXACT []
+synonym: "alpha catenin" EXACT []
+synonym: "alpha-catenin" EXACT []
+synonym: "catenin alpha" EXACT []
+synonym: "catenin α" EXACT []
+synonym: "α catenin" EXACT []
+synonym: "α-catenin" EXACT []
+xref: BEL:"CTNNA Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2509 ! CTNNA1
+relationship: inverse_is_a HGNC:2510 ! CTNNA2
+relationship: inverse_is_a HGNC:2511 ! CTNNA3
+
+[Term]
+id: FPLX:000127
+name: CUL
+synonym: "cullin proteins" EXACT []
+synonym: "cullin" EXACT []
+synonym: "cullins" EXACT []
+xref: BEL:"CUL Family"
+xref: MEDSCAN:urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9
+xref: MEDSCAN:urn:agi-protfc:cullin
+xref: NEXTPROT-FAMILY:00787
+xref: XFAM:PF00888
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2551 ! CUL1
+relationship: inverse_is_a HGNC:2552 ! CUL2
+relationship: inverse_is_a HGNC:2553 ! CUL3
+relationship: inverse_is_a HGNC:2554 ! CUL4A
+relationship: inverse_is_a HGNC:2555 ! CUL4B
+relationship: inverse_is_a HGNC:2556 ! CUL5
+relationship: inverse_is_a HGNC:21024 ! CUL7
+
+[Term]
+id: FPLX:000128
+name: CXCL-ELR-negative
+synonym: "ELR (-) CXC chemokines" EXACT []
+synonym: "ELR-negative CXC chemokine" EXACT []
+synonym: "ELR-negative CXC family" EXACT []
+synonym: "non-ELR-CXC chemokines" EXACT []
+xref: BEL:"CXCL ELR-Negative Family"
+is_a: FPLX:000099 ! Chemokine
+relationship: inverse_is_a HGNC:10637 ! CXCL10
+relationship: inverse_is_a HGNC:10638 ! CXCL11
+relationship: inverse_is_a HGNC:10672 ! CXCL12
+relationship: inverse_is_a HGNC:10639 ! CXCL13
+relationship: inverse_is_a HGNC:10640 ! CXCL14
+relationship: inverse_is_a HGNC:7098 ! CXCL9
+relationship: inverse_is_a HGNC:8861 ! PF4
+
+[Term]
+id: FPLX:000129
+name: CXCL-ELR-positive
+synonym: "ELR (+) CXC chemokines" EXACT []
+synonym: "ELR-positive CXC chemokine" EXACT []
+synonym: "ELR-positive CXC family" EXACT []
+xref: BEL:"CXCL ELR-Positive Family"
+is_a: FPLX:000099 ! Chemokine
+relationship: inverse_is_a HGNC:4602 ! CXCL1
+relationship: inverse_is_a HGNC:4603 ! CXCL2
+relationship: inverse_is_a HGNC:4604 ! CXCL3
+relationship: inverse_is_a HGNC:10642 ! CXCL5
+relationship: inverse_is_a HGNC:10643 ! CXCL6
+relationship: inverse_is_a HGNC:6025 ! CXCL8
+relationship: inverse_is_a HGNC:9240 ! PPBP
+
+[Term]
+id: FPLX:000130
+name: Cyclin
+synonym: "cyclin family" EXACT []
+synonym: "Cyclin" EXACT []
+synonym: "cyclin" EXACT []
+synonym: "cyclins" EXACT []
+xref: MEDSCAN:urn:agi-protfc:cyclin
+xref: NCIT:C17349
+xref: NEXTPROT-FAMILY:00815
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1579 ! CCNB1
+relationship: inverse_is_a HGNC:1580 ! CCNB2
+relationship: inverse_is_a HGNC:18709 ! CCNB3
+relationship: inverse_is_a HGNC:1581 ! CCNC
+relationship: inverse_is_a HGNC:1591 ! CCNF
+relationship: inverse_is_a HGNC:1592 ! CCNG1
+relationship: inverse_is_a HGNC:1593 ! CCNG2
+relationship: inverse_is_a HGNC:1594 ! CCNH
+relationship: inverse_is_a HGNC:1595 ! CCNI
+relationship: inverse_is_a HGNC:33869 ! CCNI2
+relationship: inverse_is_a HGNC:23434 ! CCNJ
+relationship: inverse_is_a HGNC:25876 ! CCNJL
+relationship: inverse_is_a HGNC:1596 ! CCNK
+relationship: inverse_is_a HGNC:20569 ! CCNL1
+relationship: inverse_is_a HGNC:20570 ! CCNL2
+relationship: inverse_is_a HGNC:18576 ! CCNO
+relationship: inverse_is_a HGNC:1599 ! CCNT1
+relationship: inverse_is_a HGNC:1600 ! CCNT2
+relationship: inverse_is_a HGNC:23354 ! CCNY
+relationship: inverse_is_a HGNC:26868 ! CCNYL1
+relationship: inverse_is_a HGNC:33206 ! CCNYL3
+relationship: inverse_is_a FPLX:000131 ! Cyclin_A
+relationship: inverse_is_a FPLX:000132 ! Cyclin_D
+relationship: inverse_is_a FPLX:000133 ! Cyclin_E
+
+[Term]
+id: FPLX:000131
+name: Cyclin-A
+synonym: "Cyclin A" EXACT []
+synonym: "cyclin A" EXACT []
+synonym: "Cyclin-A" EXACT []
+xref: BEL:"CCNA Family"
+xref: RE:R-HSA-170089
+xref: RE:R-HSA-174074
+xref: RE:R-HSA-5696998
+xref: RE:R-HSA-6783051
+xref: RE:R-HSA-75202
+is_a: FPLX:000130 ! Cyclin
+relationship: inverse_is_a HGNC:1577 ! CCNA1
+relationship: inverse_is_a HGNC:1578 ! CCNA2
+
+[Term]
+id: FPLX:000132
+name: Cyclin-D
+synonym: "Cyclin D" EXACT []
+xref: BEL:"CCND Family"
+xref: IP:IPR015451
+xref: NCIT:C104194
+xref: NEXTPROT-FAMILY:00818
+xref: RE:R-HSA-182582
+xref: RE:R-HSA-182700
+xref: RE:R-HSA-8938866
+is_a: FPLX:000130 ! Cyclin
+relationship: inverse_is_a HGNC:1582 ! CCND1
+relationship: inverse_is_a HGNC:1583 ! CCND2
+relationship: inverse_is_a HGNC:1585 ! CCND3
+
+[Term]
+id: FPLX:000133
+name: Cyclin-E
+synonym: "cyclin E" EXACT []
+xref: BEL:"CCNE Family"
+xref: IP:IPR028858
+xref: NCIT:C104197
+xref: NEXTPROT-FAMILY:00819
+xref: RE:R-HSA-157462
+xref: RE:R-HSA-187493
+xref: RE:R-HSA-6813837
+xref: RE:R-HSA-68373
+is_a: FPLX:000130 ! Cyclin
+relationship: inverse_is_a HGNC:1589 ! CCNE1
+relationship: inverse_is_a HGNC:1590 ! CCNE2
+
+[Term]
+id: FPLX:000134
+name: Cyclophilin
+synonym: "cyclophilin" EXACT []
+synonym: "cyclophilins" EXACT []
+xref: BEL:"Cyclophilin Family"
+xref: MEDSCAN:urn:agi-protfc:cyclophilins
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10664 ! CWC27
+relationship: inverse_is_a HGNC:9253 ! PPIA
+relationship: inverse_is_a HGNC:9255 ! PPIB
+relationship: inverse_is_a HGNC:9256 ! PPIC
+relationship: inverse_is_a HGNC:9257 ! PPID
+relationship: inverse_is_a HGNC:9258 ! PPIE
+relationship: inverse_is_a HGNC:9259 ! PPIF
+relationship: inverse_is_a HGNC:14651 ! PPIH
+relationship: inverse_is_a HGNC:9260 ! PPIL1
+relationship: inverse_is_a HGNC:9261 ! PPIL2
+relationship: inverse_is_a HGNC:9262 ! PPIL3
+relationship: inverse_is_a HGNC:15702 ! PPIL4
+relationship: inverse_is_a HGNC:21557 ! PPIL6
+relationship: inverse_is_a HGNC:28954 ! PPWD1
+relationship: inverse_is_a HGNC:24369 ! PPIAL4A
+relationship: inverse_is_a HGNC:33995 ! PPIAL4C
+relationship: inverse_is_a HGNC:33996 ! PPIAL4G
+
+[Term]
+id: FPLX:000135
+name: Cytoplasmic-dynein
+synonym: "cytoplasmic dynein" EXACT []
+xref: BEL:"Cytoplasmic Dynein Complex"
+xref: GO:0005868
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2961 ! DYNC1H1
+relationship: has_part HGNC:2963 ! DYNC1I1
+relationship: has_part HGNC:2964 ! DYNC1I2
+relationship: has_part HGNC:18745 ! DYNC1LI1
+relationship: has_part HGNC:2966 ! DYNC1LI2
+relationship: has_part HGNC:15476 ! DYNLL1
+relationship: has_part HGNC:15468 ! DYNLRB1
+relationship: has_part HGNC:15467 ! DYNLRB2
+
+[Term]
+id: FPLX:000136
+name: DDR
+synonym: "discoidin domain receptor family" EXACT []
+synonym: "discoidin domain receptors" EXACT []
+synonym: "discoidin domain-containing receptor" EXACT []
+xref: BEL:"DDR Family"
+xref: MEDSCAN:urn:agi-aopfc:0000252
+xref: XFAM:PF08841
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2730 ! DDR1
+relationship: inverse_is_a HGNC:2731 ! DDR2
+
+[Term]
+id: FPLX:000137
+name: Death-receptor
+synonym: "death receptor" EXACT []
+synonym: "death receptors" EXACT []
+xref: GO:0005035
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11916 ! TNFRSF1A
+relationship: inverse_is_a HGNC:11917 ! TNFRSF1B
+relationship: inverse_is_a HGNC:11904 ! TNFRSF10A
+relationship: inverse_is_a HGNC:11905 ! TNFRSF10B
+relationship: inverse_is_a HGNC:11906 ! TNFRSF10C
+relationship: inverse_is_a HGNC:11907 ! TNFRSF10D
+relationship: inverse_is_a HGNC:11920 ! FAS
+
+[Term]
+id: FPLX:000138
+name: Desmoglein
+synonym: "desmoglein" EXACT []
+synonym: "desmogleins" EXACT []
+xref: BEL:"Desmoglein Family"
+xref: IP:IPR009123
+xref: MEDSCAN:urn:agi-protfc:desmoglein
+xref: RE:R-HSA-6814694
+xref: RE:R-HSA-8847714
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3048 ! DSG1
+relationship: inverse_is_a HGNC:3049 ! DSG2
+relationship: inverse_is_a HGNC:3050 ! DSG3
+relationship: inverse_is_a HGNC:21307 ! DSG4
+
+[Term]
+id: FPLX:000139
+name: DGC
+synonym: "DGC" EXACT []
+synonym: "dystrophin glycoprotein complex" EXACT []
+synonym: "dystrophin glycoprotein" EXACT []
+synonym: "dystrophin-associated glycoprotein complex" EXACT []
+synonym: "dystrophin-glycoprotein complex" EXACT []
+xref: BEL:"Dystrophin Associated Glycoprotein Complex"
+xref: GO:0016010
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2666 ! DAG1
+relationship: has_part HGNC:2928 ! DMD
+relationship: has_part HGNC:3057 ! DTNA
+relationship: has_part HGNC:3058 ! DTNB
+relationship: has_part HGNC:7872 ! NOS1
+relationship: has_part HGNC:10805 ! SGCA
+relationship: has_part HGNC:10806 ! SGCB
+relationship: has_part HGNC:10807 ! SGCD
+relationship: has_part HGNC:10808 ! SGCE
+relationship: has_part HGNC:14075 ! SGCZ
+relationship: has_part HGNC:11167 ! SNTA1
+relationship: has_part HGNC:11168 ! SNTB1
+relationship: has_part HGNC:13740 ! SNTG1
+relationship: has_part HGNC:13741 ! SNTG2
+relationship: has_part HGNC:11322 ! SSPN
+relationship: has_part HGNC:12635 ! UTRN
+
+[Term]
+id: FPLX:000140
+name: DGK
+synonym: "DAG kinase" EXACT []
+synonym: "DGK" EXACT []
+synonym: "diacyl glycerol kinase" EXACT []
+synonym: "diacylglycerol kinase" EXACT []
+xref: BEL:"DGK Family"
+xref: ECCODE:2.7.1.107
+xref: IP:IPR000756
+xref: RE:R-HSA-426070
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2849 ! DGKA
+relationship: inverse_is_a HGNC:2850 ! DGKB
+relationship: inverse_is_a HGNC:2851 ! DGKD
+relationship: inverse_is_a HGNC:2853 ! DGKG
+relationship: inverse_is_a HGNC:2854 ! DGKH
+relationship: inverse_is_a HGNC:2856 ! DGKQ
+relationship: inverse_is_a HGNC:2857 ! DGKZ
+relationship: inverse_is_a HGNC:2852 ! DGKE
+relationship: inverse_is_a HGNC:2855 ! DGKI
+relationship: inverse_is_a HGNC:32395 ! DGKK
+
+[Term]
+id: FPLX:000141
+name: DNA-polymerase-delta
+synonym: "DNA polymerase delta" EXACT []
+synonym: "DNA polymerase δ" EXACT []
+synonym: "Pol delta" EXACT []
+synonym: "pol delta" EXACT []
+synonym: "Pol δ" EXACT []
+synonym: "pol δ" EXACT []
+xref: BEL:"DNA Polymerase delta Complex"
+xref: GO:0043625
+xref: NCIT:C16511
+xref: RE:R-HSA-68450
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9175 ! POLD1
+relationship: has_part HGNC:9176 ! POLD2
+relationship: has_part HGNC:20932 ! POLD3
+relationship: has_part HGNC:14106 ! POLD4
+
+[Term]
+id: FPLX:000142
+name: DNM
+synonym: "dynamin family" EXACT []
+synonym: "dynamin" EXACT []
+xref: BEL:"DNM Family"
+xref: RE:R-HSA-2213185
+xref: RE:R-HSA-446847
+xref: RE:R-HSA-8868235
+xref: RE:R-HSA-8868609
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2972 ! DNM1
+relationship: inverse_is_a HGNC:2974 ! DNM2
+relationship: inverse_is_a HGNC:29125 ! DNM3
+
+[Term]
+id: FPLX:000143
+name: DRD
+synonym: "dopamine receptor" EXACT []
+synonym: "dopamine receptors" EXACT []
+xref: BEL:"DRD Family"
+xref: GO:0004952
+xref: IP:IPR000929
+xref: NCIT:C17066
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3020 ! DRD1
+relationship: inverse_is_a HGNC:3023 ! DRD2
+relationship: inverse_is_a HGNC:3024 ! DRD3
+relationship: inverse_is_a HGNC:3025 ! DRD4
+relationship: inverse_is_a HGNC:3026 ! DRD5
+
+[Term]
+id: FPLX:000144
+name: DUSP
+synonym: "DUSP" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3064 ! DUSP1
+relationship: inverse_is_a HGNC:3068 ! DUSP2
+relationship: inverse_is_a HGNC:3069 ! DUSP3
+relationship: inverse_is_a HGNC:3070 ! DUSP4
+relationship: inverse_is_a HGNC:3071 ! DUSP5
+relationship: inverse_is_a HGNC:3072 ! DUSP6
+
+[Term]
+id: FPLX:000145
+name: DVL
+synonym: "dishevelled" EXACT []
+synonym: "Dvl" EXACT []
+xref: BEL:"DVL Family"
+xref: XFAM:PF02377
+xref: XFAM:PF08137
+xref: RE:R-HSA-1504201
+xref: RE:R-HSA-201689
+xref: RE:R-HSA-201725
+xref: RE:R-HSA-3772407
+xref: RE:R-HSA-3858467
+xref: RE:R-HSA-3858479
+xref: RE:R-HSA-4652685
+xref: SIGNOR:SIGNOR-PF10
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3084 ! DVL1
+relationship: inverse_is_a HGNC:3086 ! DVL2
+relationship: inverse_is_a HGNC:3087 ! DVL3
+
+[Term]
+id: FPLX:000146
+name: DYRK
+synonym: "DYRK" EXACT []
+xref: NEXTPROT-FAMILY:03091
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3091 ! DYRK1A
+relationship: inverse_is_a HGNC:3092 ! DYRK1B
+relationship: inverse_is_a HGNC:3093 ! DYRK2
+relationship: inverse_is_a HGNC:3094 ! DYRK3
+relationship: inverse_is_a HGNC:3095 ! DYRK4
+
+[Term]
+id: FPLX:000147
+name: E2F
+synonym: "E2F" EXACT []
+xref: BEL:"E2F Family"
+xref: IP:IPR015633
+xref: MEDSCAN:urn:agi-aopfc:0000099
+xref: MEDSCAN:urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3113 ! E2F1
+relationship: inverse_is_a HGNC:3114 ! E2F2
+relationship: inverse_is_a HGNC:3115 ! E2F3
+relationship: inverse_is_a HGNC:3118 ! E2F4
+relationship: inverse_is_a HGNC:3119 ! E2F5
+relationship: inverse_is_a HGNC:3120 ! E2F6
+relationship: inverse_is_a HGNC:23820 ! E2F7
+relationship: inverse_is_a HGNC:24727 ! E2F8
+
+[Term]
+id: FPLX:000148
+name: E3-Ub-ligase
+synonym: "E3 ubiquitin ligase" EXACT []
+synonym: "E3" EXACT []
+xref: XFAM:PF12483
+xref: RE:R-HSA-976075
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000149
+name: EDN
+synonym: "endothelin" EXACT []
+synonym: "endothelins" EXACT []
+xref: BEL:"EDN Family"
+xref: IP:IPR001928
+xref: IP:IPR019764
+xref: IP:IPR020475
+xref: MEDSCAN:urn:agi-protfc:endothelin
+xref: XFAM:PF00322
+xref: RE:R-HSA-388544
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3176 ! EDN1
+relationship: inverse_is_a HGNC:3177 ! EDN2
+relationship: inverse_is_a HGNC:3178 ! EDN3
+
+[Term]
+id: FPLX:000150
+name: EGFR-ligand
+synonym: "EGFR ligand" EXACT []
+synonym: "EGFR ligands" EXACT []
+xref: BEL:"EGFR Ligand Family"
+xref: GO:0005154
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:651 ! AREG
+relationship: inverse_is_a HGNC:3229 ! EGF
+relationship: inverse_is_a HGNC:11765 ! TGFA
+relationship: inverse_is_a HGNC:3059 ! HBEGF
+relationship: inverse_is_a HGNC:1121 ! BTC
+relationship: inverse_is_a HGNC:3443 ! EREG
+relationship: inverse_is_a HGNC:17470 ! EPGN
+
+[Term]
+id: FPLX:000151
+name: EGR
+synonym: "early growth response proteins" EXACT []
+synonym: "EGR" EXACT []
+xref: BEL:"EGR Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3238 ! EGR1
+relationship: inverse_is_a HGNC:3239 ! EGR2
+relationship: inverse_is_a HGNC:3240 ! EGR3
+relationship: inverse_is_a HGNC:3241 ! EGR4
+
+[Term]
+id: FPLX:000152
+name: EIF2B
+synonym: "EIF2B" EXACT []
+synonym: "eIF2B" EXACT []
+xref: BEL:"EIF2B Complex"
+xref: NCIT:C18162
+xref: RE:R-HSA-72526
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3257 ! EIF2B1
+relationship: has_part HGNC:3258 ! EIF2B2
+relationship: has_part HGNC:3259 ! EIF2B3
+relationship: has_part HGNC:3260 ! EIF2B4
+relationship: has_part HGNC:3261 ! EIF2B5
+
+[Term]
+id: FPLX:000153
+name: EIF4A
+synonym: "eIF4A" EXACT []
+synonym: "eukaryotic initiation factor-4A" EXACT []
+xref: BEL:"EIF4A Family"
+xref: NEXTPROT-FAMILY:00921
+xref: RE:R-HSA-429842
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3282 ! EIF4A1
+relationship: inverse_is_a HGNC:3284 ! EIF4A2
+relationship: inverse_is_a HGNC:18683 ! EIF4A3
+
+[Term]
+id: FPLX:000154
+name: EIF4EBP
+synonym: "4EBP" EXACT []
+synonym: "initiation factor 4E binding proteins" EXACT []
+xref: BEL:"EIF4EBP Family"
+xref: GO:0008190
+xref: IP:IPR008606
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3288 ! EIF4EBP1
+relationship: inverse_is_a HGNC:3289 ! EIF4EBP2
+relationship: inverse_is_a HGNC:3290 ! EIF4EBP3
+
+[Term]
+id: FPLX:000155
+name: EIF4G
+synonym: "eIF4G" EXACT []
+xref: XFAM:PF02854
+xref: RE:R-HSA-1678828
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3296 ! EIF4G1
+relationship: inverse_is_a HGNC:3297 ! EIF4G2
+relationship: inverse_is_a HGNC:3298 ! EIF4G3
+
+[Term]
+id: FPLX:000156
+name: ELA
+synonym: "elastase" EXACT []
+xref: BEL:"ELA Family"
+xref: NEXTPROT-FAMILY:02762
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:913 ! AZU1
+relationship: inverse_is_a HGNC:3308 ! CELA1
+relationship: inverse_is_a HGNC:24609 ! CELA2A
+relationship: inverse_is_a HGNC:29995 ! CELA2B
+relationship: inverse_is_a HGNC:15944 ! CELA3A
+relationship: inverse_is_a HGNC:15945 ! CELA3B
+relationship: inverse_is_a HGNC:2523 ! CTRC
+relationship: inverse_is_a HGNC:3309 ! ELANE
+relationship: inverse_is_a HGNC:9495 ! PRTN3
+
+[Term]
+id: FPLX:000157
+name: ENO
+synonym: "enolase" EXACT []
+xref: BEL:"ENO Family"
+xref: IP:IPR000941
+xref: IP:IPR020810
+xref: IP:IPR020811
+xref: NEXTPROT-FAMILY:01112
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3350 ! ENO1
+relationship: inverse_is_a HGNC:3353 ! ENO2
+relationship: inverse_is_a HGNC:3354 ! ENO3
+relationship: inverse_is_a HGNC:31670 ! ENO4
+
+[Term]
+id: FPLX:000158
+name: Ephrin-receptor
+synonym: "Eph receptor" EXACT []
+synonym: "Eph receptors" EXACT []
+synonym: "ephrin receptor" EXACT []
+xref: BEL:"Ephrin Receptor Family"
+xref: IP:IPR001090
+xref: IP:IPR001426
+xref: IP:IPR016257
+xref: IP:IPR027936
+xref: NCIT:C18606
+xref: NEXTPROT-FAMILY:03124
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3385 ! EPHA1
+relationship: inverse_is_a HGNC:3386 ! EPHA2
+relationship: inverse_is_a HGNC:3387 ! EPHA3
+relationship: inverse_is_a HGNC:3388 ! EPHA4
+relationship: inverse_is_a HGNC:3389 ! EPHA5
+relationship: inverse_is_a HGNC:19296 ! EPHA6
+relationship: inverse_is_a HGNC:3390 ! EPHA7
+relationship: inverse_is_a HGNC:3391 ! EPHA8
+relationship: inverse_is_a HGNC:3392 ! EPHB1
+relationship: inverse_is_a HGNC:3393 ! EPHB2
+relationship: inverse_is_a HGNC:3394 ! EPHB3
+relationship: inverse_is_a HGNC:3395 ! EPHB4
+relationship: inverse_is_a HGNC:3396 ! EPHB6
+relationship: inverse_is_a HGNC:19987 ! EPHA10
+
+[Term]
+id: FPLX:000159
+name: EPN
+synonym: "epsin" EXACT []
+synonym: "epsins" EXACT []
+xref: BEL:"EPN Family"
+xref: NEXTPROT-FAMILY:01121
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:21604 ! EPN1
+relationship: inverse_is_a HGNC:18639 ! EPN2
+relationship: inverse_is_a HGNC:18235 ! EPN3
+relationship: inverse_is_a HGNC:23186 ! CLINT1
+
+[Term]
+id: FPLX:000160
+name: ERBB
+synonym: "ErbB" EXACT []
+synonym: "erbB" EXACT []
+xref: BEL:"EGFR/ERBB Family"
+xref: IP:IPR016245
+xref: NCIT:C17763
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3236 ! EGFR
+relationship: inverse_is_a HGNC:3430 ! ERBB2
+relationship: inverse_is_a HGNC:3431 ! ERBB3
+relationship: inverse_is_a HGNC:3432 ! ERBB4
+
+[Term]
+id: FPLX:000161
+name: ERK
+synonym: "ERK 1/2" EXACT []
+synonym: "ERK MAPK" EXACT []
+synonym: "ERK mitogen-activated protein kinase" EXACT []
+synonym: "ERK" EXACT []
+synonym: "Erk" EXACT []
+synonym: "ERK-1/2" EXACT []
+synonym: "ERK1/2 MAPK" EXACT []
+synonym: "ERK1/2" EXACT []
+synonym: "Erk1/2" EXACT []
+synonym: "ERKs" EXACT []
+synonym: "Extracellular Signal Regulated Kinase" EXACT []
+synonym: "extracellular signal-regulated kinase" EXACT []
+synonym: "MAPK" EXACT []
+synonym: "phospho-ERK1/2" EXACT []
+xref: BEL:"MAPK Erk1/2 Family"
+xref: BEL:"MAPK Erk1/3 Family"
+xref: IP:IPR008349
+xref: MEDSCAN:urn:agi-aopfc:0000458
+xref: NCIT:C16376
+xref: NCIT:C26360
+xref: RE:R-HSA-1268261
+xref: RE:R-HSA-169289
+xref: RE:R-HSA-169291
+xref: RE:R-HSA-198701
+xref: RE:R-HSA-2422450
+xref: RE:R-HSA-3656389
+xref: RE:R-HSA-5674338
+xref: RE:R-HSA-5674340
+xref: RE:R-HSA-5674341
+xref: RE:R-HSA-5675361
+xref: RE:R-HSA-5675363
+xref: SIGNOR:SIGNOR-PF1
+is_a: FPLX:000283 ! MAPK
+relationship: inverse_is_a HGNC:6871 ! MAPK1
+relationship: inverse_is_a HGNC:6877 ! MAPK3
+
+[Term]
+id: FPLX:000162
+name: ESR
+synonym: "ER" EXACT []
+synonym: "ESR" EXACT []
+xref: BEL:"ESR Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3467 ! ESR1
+relationship: inverse_is_a HGNC:3468 ! ESR2
+
+[Term]
+id: FPLX:000163
+name: ETS
+synonym: "ETS" EXACT []
+xref: BEL:"ETS Family"
+xref: IP:IPR016311
+xref: XFAM:PF00178
+xref: RE:R-HSA-3132719
+xref: RE:R-HSA-3132724
+xref: RE:R-HSA-3200029
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3488 ! ETS1
+relationship: inverse_is_a HGNC:3489 ! ETS2
+
+[Term]
+id: FPLX:000164
+name: EXOC
+synonym: "EXOC" EXACT []
+synonym: "exocyst complex" EXACT []
+synonym: "exocyst" EXACT []
+xref: GO:0000145
+xref: RE:R-HSA-264974
+xref: RE:R-HSA-5623453
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:30380 ! EXOC1
+relationship: has_part HGNC:24968 ! EXOC2
+relationship: has_part HGNC:30378 ! EXOC3
+relationship: has_part HGNC:30389 ! EXOC4
+relationship: has_part HGNC:10696 ! EXOC5
+relationship: has_part HGNC:23196 ! EXOC6
+relationship: has_part HGNC:23214 ! EXOC7
+relationship: has_part HGNC:24659 ! EXOC8
+
+[Term]
+id: FPLX:000165
+name: EXT
+synonym: "Exostosin glycosyltransferase family" EXACT []
+synonym: "exostosin glycosyltransferase family" EXACT []
+synonym: "EXT" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:3515 ! EXTL1
+relationship: inverse_is_a HGNC:3516 ! EXTL2
+relationship: inverse_is_a HGNC:3518 ! EXTL3
+relationship: inverse_is_a HGNC:3512 ! EXT1
+relationship: inverse_is_a HGNC:3513 ! EXT2
+
+[Term]
+id: FPLX:000166
+name: FANC
+synonym: "FANC proteins" EXACT []
+synonym: "FANC" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3582 ! FANCA
+relationship: inverse_is_a HGNC:3583 ! FANCB
+relationship: inverse_is_a HGNC:3584 ! FANCC
+relationship: inverse_is_a HGNC:1101 ! BRCA2
+relationship: inverse_is_a HGNC:3585 ! FANCD2
+relationship: inverse_is_a HGNC:3586 ! FANCE
+relationship: inverse_is_a HGNC:3587 ! FANCF
+relationship: inverse_is_a HGNC:3588 ! FANCG
+relationship: inverse_is_a HGNC:25568 ! FANCI
+relationship: inverse_is_a HGNC:20473 ! BRIP1
+relationship: inverse_is_a HGNC:20748 ! FANCL
+relationship: inverse_is_a HGNC:23168 ! FANCM
+relationship: inverse_is_a HGNC:26144 ! PALB2
+relationship: inverse_is_a HGNC:9820 ! RAD51C
+relationship: inverse_is_a HGNC:23845 ! SLX4
+relationship: inverse_is_a HGNC:3436 ! ERCC4
+relationship: inverse_is_a HGNC:9817 ! RAD51
+relationship: inverse_is_a HGNC:1100 ! BRCA1
+relationship: inverse_is_a HGNC:25009 ! UBE2T
+relationship: inverse_is_a HGNC:12829 ! XRCC2
+
+[Term]
+id: FPLX:000167
+name: FGF
+synonym: "FGF" EXACT []
+xref: BEL:"FGF Family"
+xref: GO:0005162
+xref: IP:IPR002209
+xref: XFAM:PF00167
+xref: SIGNOR:SIGNOR-PF8
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3665 ! FGF1
+relationship: inverse_is_a HGNC:3676 ! FGF2
+relationship: inverse_is_a HGNC:3681 ! FGF3
+relationship: inverse_is_a HGNC:3682 ! FGF4
+relationship: inverse_is_a HGNC:3683 ! FGF5
+relationship: inverse_is_a HGNC:3684 ! FGF6
+relationship: inverse_is_a HGNC:3685 ! FGF7
+relationship: inverse_is_a HGNC:3686 ! FGF8
+relationship: inverse_is_a HGNC:3687 ! FGF9
+relationship: inverse_is_a HGNC:3666 ! FGF10
+relationship: inverse_is_a HGNC:3667 ! FGF11
+relationship: inverse_is_a HGNC:3668 ! FGF12
+relationship: inverse_is_a HGNC:3670 ! FGF13
+relationship: inverse_is_a HGNC:3671 ! FGF14
+relationship: inverse_is_a HGNC:3672 ! FGF16
+relationship: inverse_is_a HGNC:3673 ! FGF17
+relationship: inverse_is_a HGNC:3674 ! FGF18
+relationship: inverse_is_a HGNC:3675 ! FGF19
+relationship: inverse_is_a HGNC:3677 ! FGF20
+relationship: inverse_is_a HGNC:3678 ! FGF21
+relationship: inverse_is_a HGNC:3679 ! FGF22
+relationship: inverse_is_a HGNC:3680 ! FGF23
+
+[Term]
+id: FPLX:000168
+name: FGFR
+synonym: "FGFR" EXACT []
+xref: BEL:"FGFR Family"
+xref: GO:0005007
+xref: IP:IPR016248
+xref: NCIT:C17297
+xref: SIGNOR:SIGNOR-PF23
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3688 ! FGFR1
+relationship: inverse_is_a HGNC:3689 ! FGFR2
+relationship: inverse_is_a HGNC:3690 ! FGFR3
+relationship: inverse_is_a HGNC:3691 ! FGFR4
+relationship: inverse_is_a HGNC:3693 ! FGFRL1
+
+[Term]
+id: FPLX:000169
+name: Fibrinogen
+synonym: "fibrinogen" EXACT []
+xref: BEL:"Fibrinogen Complex"
+xref: GO:0005577
+xref: IP:IPR012290
+xref: RE:R-HSA-114617
+xref: RE:R-HSA-114618
+xref: RE:R-HSA-139933
+xref: RE:R-HSA-139934
+xref: RE:R-HSA-140586
+xref: RE:R-HSA-140919
+xref: RE:R-HSA-8870680
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3661 ! FGA
+relationship: has_part HGNC:3662 ! FGB
+relationship: has_part HGNC:3694 ! FGG
+
+[Term]
+id: FPLX:000170
+name: FLOT
+synonym: "flotillin" EXACT []
+xref: BEL:"FLOT Family"
+xref: IP:IPR027705
+xref: IP:IPR031905
+xref: MEDSCAN:urn:agi-protfc:flotillin
+xref: XFAM:PF15975
+xref: RE:R-HSA-8849894
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3757 ! FLOT1
+relationship: inverse_is_a HGNC:3758 ! FLOT2
+
+[Term]
+id: FPLX:000171
+name: FLRT
+synonym: "FLRT family" EXACT []
+synonym: "Flrt family" EXACT []
+synonym: "FLRT proteins" EXACT []
+xref: BEL:"FLRT Family"
+xref: RE:R-HSA-5656056
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3760 ! FLRT1
+relationship: inverse_is_a HGNC:3761 ! FLRT2
+relationship: inverse_is_a HGNC:3762 ! FLRT3
+
+[Term]
+id: FPLX:000172
+name: FNT
+synonym: "farnesyltransferase" EXACT []
+synonym: "FTase" EXACT []
+synonym: "protein farnesyltransferase" EXACT []
+xref: ECCODE:2.5.1.58
+xref: RE:R-HSA-2530496
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3782 ! FNTA
+relationship: has_part HGNC:3785 ! FNTB
+
+[Term]
+id: FPLX:000173
+name: FOS-family
+synonym: "FOS" EXACT []
+synonym: "Fos" EXACT []
+xref: NEXTPROT-FAMILY:00408
+relationship: part_of FPLX:000048 ! AP1
+relationship: inverse_is_a HGNC:3796 ! FOS
+relationship: inverse_is_a HGNC:3797 ! FOSB
+relationship: inverse_is_a HGNC:13718 ! FOSL1
+relationship: inverse_is_a HGNC:3798 ! FOSL2
+
+[Term]
+id: FPLX:000174
+name: FOXO
+synonym: "FOXO" EXACT []
+synonym: "FoxO" EXACT []
+xref: BEL:"FOXO Family"
+xref: IP:IPR032067
+xref: NCIT:C118892
+xref: SIGNOR:SIGNOR-PF27
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3819 ! FOXO1
+relationship: inverse_is_a HGNC:3821 ! FOXO3
+relationship: inverse_is_a HGNC:7139 ! FOXO4
+relationship: inverse_is_a HGNC:24814 ! FOXO6
+
+[Term]
+id: FPLX:000175
+name: FSH
+synonym: "follicle-stimulating hormone" EXACT []
+synonym: "FSH" EXACT []
+xref: BEL:"Follicle Stimulating Hormone Complex"
+xref: GO:0016914
+xref: RE:R-HSA-378947
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1885 ! CGA
+relationship: has_part HGNC:3964 ! FSHB
+
+[Term]
+id: FPLX:000176
+name: FUT
+synonym: "Fucosyltransferase" EXACT []
+synonym: "Fucosyltransferases" EXACT []
+synonym: "fucosyltransferase" EXACT []
+synonym: "fucosyltransferases" EXACT []
+synonym: "FUT" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:4012 ! FUT1
+relationship: inverse_is_a HGNC:4013 ! FUT2
+relationship: inverse_is_a HGNC:4014 ! FUT3
+relationship: inverse_is_a HGNC:4015 ! FUT4
+relationship: inverse_is_a HGNC:4016 ! FUT5
+relationship: inverse_is_a HGNC:4017 ! FUT6
+relationship: inverse_is_a HGNC:4018 ! FUT7
+relationship: inverse_is_a HGNC:4019 ! FUT8
+relationship: inverse_is_a HGNC:4020 ! FUT9
+relationship: inverse_is_a HGNC:19234 ! FUT10
+relationship: inverse_is_a HGNC:19233 ! FUT11
+relationship: inverse_is_a HGNC:14988 ! POFUT1
+relationship: inverse_is_a HGNC:14683 ! POFUT2
+
+[Term]
+id: FPLX:000177
+name: FZD
+synonym: "Fz" EXACT []
+synonym: "FZD" EXACT []
+xref: BEL:"FZD Family"
+xref: MEDSCAN:urn:agi-aopfc:0000197
+xref: MEDSCAN:urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267
+xref: XFAM:PF01534
+xref: RE:R-HSA-517388
+xref: SIGNOR:SIGNOR-PF11
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4038 ! FZD1
+relationship: inverse_is_a HGNC:4039 ! FZD10
+relationship: inverse_is_a HGNC:4040 ! FZD2
+relationship: inverse_is_a HGNC:4041 ! FZD3
+relationship: inverse_is_a HGNC:4042 ! FZD4
+relationship: inverse_is_a HGNC:4043 ! FZD5
+relationship: inverse_is_a HGNC:4044 ! FZD6
+relationship: inverse_is_a HGNC:4045 ! FZD7
+relationship: inverse_is_a HGNC:4046 ! FZD8
+relationship: inverse_is_a HGNC:4047 ! FZD9
+
+[Term]
+id: FPLX:000178
+name: F-actin
+synonym: "F-actin" EXACT []
+xref: GO:0031941
+xref: MEDSCAN:urn:agi-protfc:F-actin-binding%20protein
+is_a: FPLX:000009 ! Actin
+
+[Term]
+id: FPLX:000179
+name: GABR
+synonym: "GABA receptor" EXACT []
+synonym: "GABA receptors" EXACT []
+synonym: "GABA-A receptor" EXACT []
+synonym: "gamma-aminobutyric-acid A receptor" EXACT []
+synonym: "γ-aminobutyric-acid A receptor" EXACT []
+xref: BEL:"GABR Family"
+xref: GO:0004890
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4075 ! GABRA1
+relationship: inverse_is_a HGNC:4076 ! GABRA2
+relationship: inverse_is_a HGNC:4077 ! GABRA3
+relationship: inverse_is_a HGNC:4078 ! GABRA4
+relationship: inverse_is_a HGNC:4079 ! GABRA5
+relationship: inverse_is_a HGNC:4080 ! GABRA6
+relationship: inverse_is_a HGNC:4081 ! GABRB1
+relationship: inverse_is_a HGNC:4082 ! GABRB2
+relationship: inverse_is_a HGNC:4083 ! GABRB3
+relationship: inverse_is_a HGNC:4084 ! GABRD
+relationship: inverse_is_a HGNC:4085 ! GABRE
+relationship: inverse_is_a HGNC:4086 ! GABRG1
+relationship: inverse_is_a HGNC:4087 ! GABRG2
+relationship: inverse_is_a HGNC:4088 ! GABRG3
+relationship: inverse_is_a HGNC:4089 ! GABRP
+relationship: inverse_is_a HGNC:14454 ! GABRQ
+relationship: inverse_is_a HGNC:4090 ! GABRR1
+relationship: inverse_is_a HGNC:4091 ! GABRR2
+relationship: inverse_is_a HGNC:17969 ! GABRR3
+
+[Term]
+id: FPLX:000180
+name: GALNT
+synonym: "GALNT" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:21725 ! GALNTL5
+relationship: inverse_is_a HGNC:33844 ! GALNTL6
+relationship: inverse_is_a HGNC:4123 ! GALNT1
+relationship: inverse_is_a HGNC:4124 ! GALNT2
+relationship: inverse_is_a HGNC:4125 ! GALNT3
+relationship: inverse_is_a HGNC:4126 ! GALNT4
+relationship: inverse_is_a HGNC:4127 ! GALNT5
+relationship: inverse_is_a HGNC:4128 ! GALNT6
+relationship: inverse_is_a HGNC:4129 ! GALNT7
+relationship: inverse_is_a HGNC:4130 ! GALNT8
+relationship: inverse_is_a HGNC:4131 ! GALNT9
+relationship: inverse_is_a HGNC:19873 ! GALNT10
+relationship: inverse_is_a HGNC:19875 ! GALNT11
+relationship: inverse_is_a HGNC:19877 ! GALNT12
+relationship: inverse_is_a HGNC:23242 ! GALNT13
+relationship: inverse_is_a HGNC:22946 ! GALNT14
+relationship: inverse_is_a HGNC:21531 ! GALNT15
+relationship: inverse_is_a HGNC:23233 ! GALNT16
+relationship: inverse_is_a HGNC:30488 ! GALNT18
+relationship: inverse_is_a HGNC:16347 ! GALNT17
+
+[Term]
+id: FPLX:000181
+name: Gamma-secretase
+synonym: "gamma secretase" EXACT []
+synonym: "gamma-secretase" EXACT []
+synonym: "γ secretase" EXACT []
+xref: BEL:"gamma Secretase Complex"
+xref: GO:0070765
+xref: NCIT:C95114
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:29509 ! APH1A
+relationship: has_part HGNC:9508 ! PSEN1
+relationship: has_part HGNC:30100 ! PSENEN
+
+[Term]
+id: FPLX:000182
+name: GAP
+synonym: "GAP" EXACT []
+synonym: "GTPase-activating proteins" EXACT []
+xref: GO:0005096
+xref: NCIT:C17298
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000183
+name: GAS6-receptor
+synonym: "Gas6 receptors" EXACT []
+xref: BEL:"GAS6 Receptor Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:905 ! AXL
+relationship: inverse_is_a HGNC:7027 ! MERTK
+relationship: inverse_is_a HGNC:12446 ! TYRO3
+
+[Term]
+id: FPLX:000184
+name: GATA
+synonym: "GATA family" EXACT []
+synonym: "GATA" EXACT []
+xref: BEL:"GATA Family"
+xref: MEDSCAN:urn:agi-aopfc:0000105
+xref: XFAM:PF00320
+xref: RE:R-HSA-996770
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4170 ! GATA1
+relationship: inverse_is_a HGNC:4171 ! GATA2
+relationship: inverse_is_a HGNC:4172 ! GATA3
+relationship: inverse_is_a HGNC:4173 ! GATA4
+relationship: inverse_is_a HGNC:15802 ! GATA5
+relationship: inverse_is_a HGNC:4174 ! GATA6
+
+[Term]
+id: FPLX:000185
+name: GCNT
+synonym: "GCNT" EXACT []
+synonym: "XYLT" EXACT []
+synonym: "Xylosyltransferase" EXACT []
+synonym: "Xylosyltransferases" EXACT []
+synonym: "xylosyltransferase" EXACT []
+synonym: "xylosyltransferases" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:4203 ! GCNT1
+relationship: inverse_is_a HGNC:4204 ! GCNT2
+relationship: inverse_is_a HGNC:4205 ! GCNT3
+relationship: inverse_is_a HGNC:17973 ! GCNT4
+relationship: inverse_is_a HGNC:16099 ! GCNT7
+relationship: inverse_is_a HGNC:15516 ! XYLT1
+relationship: inverse_is_a HGNC:15517 ! XYLT2
+
+[Term]
+id: FPLX:000186
+name: GEF
+synonym: "GEF" EXACT []
+synonym: "GEFs" EXACT []
+xref: GO:0008433
+xref: NCIT:C17494
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000187
+name: GPCR
+synonym: "Class C GPCR" EXACT []
+synonym: "GPCR" EXACT []
+synonym: "GPCRs" EXACT []
+xref: MEDSCAN:urn:agi-aopfc:0000311
+xref: MEDSCAN:urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da
+xref: MEDSCAN:urn:agi-protfc:class%20c%20orphan%20receptor
+xref: NCIT:C18239
+xref: SIGNOR:SIGNOR-PF33
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000188
+name: GPIb-IX-V
+synonym: "glycoprotein Ib-V-IX complex" EXACT []
+synonym: "Glycoprotein Ib-V-IX" EXACT []
+synonym: "Glycoprotein Ib/V/IX" EXACT []
+synonym: "GPIb-IX-V complex" EXACT []
+synonym: "GPIb-IX-V" EXACT []
+synonym: "GpIb-V-IX" EXACT []
+xref: BEL:"Ib-V-IX Complex"
+xref: GO:1990779
+xref: NCIT:C126122
+xref: RE:R-HSA-114668
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4439 ! GP1BA
+relationship: has_part HGNC:4440 ! GP1BB
+relationship: has_part HGNC:4443 ! GP5
+relationship: has_part HGNC:4444 ! GP9
+
+[Term]
+id: FPLX:000189
+name: GPIT
+synonym: "glycosylphosphatidylinositol transamidase complex" EXACT []
+synonym: "GPI transamidase complex" EXACT []
+synonym: "GPIT complex" EXACT []
+synonym: "GPIT" EXACT []
+xref: BEL:"GPIT Complex"
+xref: RE:R-HSA-162690
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4446 ! GPAA1
+relationship: has_part HGNC:8965 ! PIGK
+relationship: has_part HGNC:14937 ! PIGS
+relationship: has_part HGNC:14938 ! PIGT
+relationship: has_part HGNC:15791 ! PIGU
+
+[Term]
+id: FPLX:000190
+name: GPX
+synonym: "glutathione peroxidase" EXACT []
+xref: BEL:"GPX Family"
+xref: ECCODE:1.11.1.9
+xref: IP:IPR000889
+xref: IP:IPR029760
+xref: NEXTPROT-FAMILY:01553
+xref: XFAM:PF00255
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4553 ! GPX1
+relationship: inverse_is_a HGNC:4554 ! GPX2
+relationship: inverse_is_a HGNC:4555 ! GPX3
+relationship: inverse_is_a HGNC:4556 ! GPX4
+relationship: inverse_is_a HGNC:4557 ! GPX5
+relationship: inverse_is_a HGNC:4558 ! GPX6
+relationship: inverse_is_a HGNC:4559 ! GPX7
+relationship: inverse_is_a HGNC:33100 ! GPX8
+
+[Term]
+id: FPLX:000191
+name: GRIA
+synonym: "AMPA glutamate receptor" EXACT []
+synonym: "AMPA receptor" EXACT []
+synonym: "AMPA-R" EXACT []
+synonym: "AMPA-subtype ionotropic glutamate receptors" EXACT []
+synonym: "AMPAR" EXACT []
+synonym: "AMPARs" EXACT []
+xref: BEL:"GRIA Family"
+xref: GO:0032281
+xref: RE:R-HSA-399713
+xref: RE:R-HSA-416323
+xref: RE:R-HSA-420974
+xref: RE:R-HSA-421001
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4571 ! GRIA1
+relationship: inverse_is_a HGNC:4572 ! GRIA2
+relationship: inverse_is_a HGNC:4573 ! GRIA3
+relationship: inverse_is_a HGNC:4574 ! GRIA4
+
+[Term]
+id: FPLX:000192
+name: GRK
+synonym: "G protein-coupled receptor kinases" EXACT []
+synonym: "GPCR kinases" EXACT []
+synonym: "GRK" EXACT []
+synonym: "GRKs" EXACT []
+xref: BEL:"GRK Family"
+xref: ECCODE:2.7.11.16
+xref: IP:IPR000239
+xref: NCIT:C26233
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000022 ! ADRBK
+relationship: inverse_is_a HGNC:10013 ! GRK1
+relationship: inverse_is_a HGNC:4543 ! GRK4
+relationship: inverse_is_a HGNC:4544 ! GRK5
+relationship: inverse_is_a HGNC:4545 ! GRK6
+relationship: inverse_is_a HGNC:17031 ! GRK7
+
+[Term]
+id: FPLX:000193
+name: GRM
+synonym: "glutamate metabotropic receptors" EXACT []
+synonym: "metabotrophic glutamate receptor" EXACT []
+synonym: "metabotropic glutamate receptor" EXACT []
+synonym: "mGluRs" EXACT []
+xref: BEL:"GRM Family"
+xref: IP:IPR000162
+xref: MEDSCAN:urn:agi-protfc:mglur
+xref: RE:R-HSA-420516
+xref: RE:R-HSA-420519
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4593 ! GRM1
+relationship: inverse_is_a HGNC:4594 ! GRM2
+relationship: inverse_is_a HGNC:4595 ! GRM3
+relationship: inverse_is_a HGNC:4596 ! GRM4
+relationship: inverse_is_a HGNC:4597 ! GRM5
+relationship: inverse_is_a HGNC:4598 ! GRM6
+relationship: inverse_is_a HGNC:4599 ! GRM7
+relationship: inverse_is_a HGNC:4600 ! GRM8
+
+[Term]
+id: FPLX:000194
+name: GSK3
+synonym: "GSK-3" EXACT []
+synonym: "GSK3" EXACT []
+xref: BEL:"GSK3 Family"
+xref: MEDSCAN:urn:agi-aopfc:0000434
+xref: NEXTPROT-FAMILY:03087
+xref: RE:R-HSA-198358
+xref: RE:R-HSA-198373
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4616 ! GSK3A
+relationship: inverse_is_a HGNC:4617 ! GSK3B
+
+[Term]
+id: FPLX:000195
+name: GST
+synonym: "glutathione S-transferase" EXACT []
+synonym: "GST" EXACT []
+synonym: "GSTs" EXACT []
+xref: BEL:"GST Family"
+xref: NCIT:C16641
+xref: NEXTPROT-FAMILY:01669
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4626 ! GSTA1
+relationship: inverse_is_a HGNC:4627 ! GSTA2
+relationship: inverse_is_a HGNC:4628 ! GSTA3
+relationship: inverse_is_a HGNC:4629 ! GSTA4
+relationship: inverse_is_a HGNC:19662 ! GSTA5
+relationship: inverse_is_a HGNC:16906 ! GSTK1
+relationship: inverse_is_a HGNC:4632 ! GSTM1
+relationship: inverse_is_a HGNC:4634 ! GSTM2
+relationship: inverse_is_a HGNC:4635 ! GSTM3
+relationship: inverse_is_a HGNC:4636 ! GSTM4
+relationship: inverse_is_a HGNC:4637 ! GSTM5
+relationship: inverse_is_a HGNC:13312 ! GSTO1
+relationship: inverse_is_a HGNC:23064 ! GSTO2
+relationship: inverse_is_a HGNC:4638 ! GSTP1
+relationship: inverse_is_a HGNC:4641 ! GSTT1
+relationship: inverse_is_a HGNC:4642 ! GSTT2
+relationship: inverse_is_a HGNC:4643 ! GSTZ1
+relationship: inverse_is_a HGNC:33437 ! GSTT2B
+
+[Term]
+id: FPLX:000196
+name: GTF2E
+synonym: "general transcription factor II E" EXACT []
+synonym: "TFIIE" EXACT []
+synonym: "transcription factor II E" EXACT []
+synonym: "transcription factor IIE" EXACT []
+xref: BEL:"GTF2E Complex"
+xref: GO:0005673
+xref: RE:R-HSA-109633
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4650 ! GTF2E1
+relationship: has_part HGNC:4651 ! GTF2E2
+
+[Term]
+id: FPLX:000197
+name: GTF2F
+synonym: "general transcription factor II F" EXACT []
+synonym: "TFIIF" EXACT []
+synonym: "transcription factor II F" EXACT []
+synonym: "transcription factor IIF" EXACT []
+xref: BEL:"GTF2F Complex"
+xref: GO:0005674
+xref: IP:IPR011039
+xref: RE:R-HSA-109631
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4652 ! GTF2F1
+relationship: has_part HGNC:4653 ! GTF2F2
+
+[Term]
+id: FPLX:000198
+name: Glycosyltransferase
+xref: MESH:D016695
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000002 ! A4GALT_family
+relationship: inverse_is_a FPLX:000026 ! ALG10
+relationship: inverse_is_a FPLX:000027 ! ALG1_family
+relationship: inverse_is_a FPLX:000028 ! ALG3_family
+relationship: inverse_is_a FPLX:000029 ! ALG6_family
+relationship: inverse_is_a FPLX:000030 ! ALG13_family
+relationship: inverse_is_a FPLX:000063 ! B3GAT
+relationship: inverse_is_a FPLX:000065 ! Beta_3_4_GTF
+relationship: inverse_is_a FPLX:000112 ! COLGALT
+relationship: inverse_is_a FPLX:000165 ! EXT
+relationship: inverse_is_a FPLX:000176 ! FUT
+relationship: inverse_is_a FPLX:000180 ! GALNT
+relationship: inverse_is_a FPLX:000185 ! GCNT
+relationship: inverse_is_a FPLX:000199 ! GTF_family_2
+relationship: inverse_is_a FPLX:000200 ! GTF_family_6
+relationship: inverse_is_a FPLX:000201 ! GTF_family_8
+relationship: inverse_is_a FPLX:000202 ! GTF_family_29
+relationship: inverse_is_a FPLX:000203 ! GTF_family_90
+relationship: inverse_is_a FPLX:000287 ! MGAT
+relationship: inverse_is_a FPLX:000322 ! OGT_family
+relationship: inverse_is_a FPLX:000396 ! PYG
+relationship: inverse_is_a FPLX:000455 ! STT3
+relationship: inverse_is_a FPLX:000491 ! UGCG
+relationship: inverse_is_a FPLX:000492 ! UGT
+relationship: inverse_is_a FPLX:000493 ! UGGT
+
+[Term]
+id: FPLX:000199
+name: GTF-family-2
+synonym: "Glycosyltransferase family 2" EXACT []
+synonym: "glycosyltransferase family 2" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:20266 ! ALG5
+relationship: inverse_is_a HGNC:21727 ! B3GNTL1
+relationship: inverse_is_a HGNC:3005 ! DPM1
+relationship: inverse_is_a HGNC:4818 ! HAS1
+relationship: inverse_is_a HGNC:4819 ! HAS2
+relationship: inverse_is_a HGNC:4820 ! HAS3
+
+[Term]
+id: FPLX:000200
+name: GTF-family-6
+synonym: "Glycosyltransferase family 6" EXACT []
+synonym: "glycosyltransferase family 6" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:79 ! ABO
+relationship: inverse_is_a HGNC:30005 ! A3GALT2
+relationship: inverse_is_a HGNC:20460 ! GBGT1
+relationship: inverse_is_a HGNC:23671 ! GLT6D1
+
+[Term]
+id: FPLX:000201
+name: GTF-family-8
+synonym: "Glycosyltransferase family 8" EXACT []
+synonym: "glycosyltransferase family 8" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:24870 ! GLT8D1
+relationship: inverse_is_a HGNC:24890 ! GLT8D2
+relationship: inverse_is_a HGNC:27482 ! GXYLT1
+relationship: inverse_is_a HGNC:33383 ! GXYLT2
+relationship: inverse_is_a HGNC:4699 ! GYG1
+relationship: inverse_is_a HGNC:4700 ! GYG2
+relationship: inverse_is_a HGNC:6511 ! LARGE1
+relationship: inverse_is_a HGNC:16522 ! LARGE2
+relationship: inverse_is_a HGNC:13530 ! RXYLT1
+relationship: inverse_is_a HGNC:26639 ! XXYLT1
+
+[Term]
+id: FPLX:000202
+name: GTF-family-29
+synonym: "Glycosyltransferase family 29" EXACT []
+synonym: "glycosyltransferase family 29" EXACT []
+synonym: "Sialytransferase" EXACT []
+synonym: "Sialytransferases" EXACT []
+synonym: "sialytransferase" EXACT []
+synonym: "sialytransferases" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:10862 ! ST3GAL1
+relationship: inverse_is_a HGNC:10863 ! ST3GAL2
+relationship: inverse_is_a HGNC:10866 ! ST3GAL3
+relationship: inverse_is_a HGNC:10864 ! ST3GAL4
+relationship: inverse_is_a HGNC:10872 ! ST3GAL5
+relationship: inverse_is_a HGNC:18080 ! ST3GAL6
+relationship: inverse_is_a HGNC:23614 ! ST6GALNAC1
+relationship: inverse_is_a HGNC:10867 ! ST6GALNAC2
+relationship: inverse_is_a HGNC:19343 ! ST6GALNAC3
+relationship: inverse_is_a HGNC:17846 ! ST6GALNAC4
+relationship: inverse_is_a HGNC:19342 ! ST6GALNAC5
+relationship: inverse_is_a HGNC:23364 ! ST6GALNAC6
+relationship: inverse_is_a HGNC:10860 ! ST6GAL1
+relationship: inverse_is_a HGNC:10861 ! ST6GAL2
+relationship: inverse_is_a HGNC:10869 ! ST8SIA1
+relationship: inverse_is_a HGNC:10870 ! ST8SIA2
+relationship: inverse_is_a HGNC:14269 ! ST8SIA3
+relationship: inverse_is_a HGNC:10871 ! ST8SIA4
+relationship: inverse_is_a HGNC:17827 ! ST8SIA5
+relationship: inverse_is_a HGNC:23317 ! ST8SIA6
+
+[Term]
+id: FPLX:000203
+name: GTF-family-90
+synonym: "Glycosyltransferase family 90" EXACT []
+synonym: "glycosyltransferase family 90" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:19350 ! POGLUT2
+relationship: inverse_is_a HGNC:28496 ! POGLUT3
+relationship: inverse_is_a HGNC:22954 ! POGLUT1
+
+[Term]
+id: FPLX:000204
+name: GTPase
+synonym: "GTPase" EXACT []
+xref: ECCODE:3.6.5.-
+xref: MEDSCAN:urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196
+xref: NCIT:C16650
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000205
+name: GUCY
+synonym: "guanylate cyclase" EXACT []
+synonym: "guanylyl cyclase" EXACT []
+xref: BEL:"GUCY Family"
+xref: ECCODE:4.6.1.2
+xref: NCIT:C16653
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4688 ! GUCY2C
+relationship: inverse_is_a HGNC:4689 ! GUCY2D
+relationship: inverse_is_a HGNC:4691 ! GUCY2F
+relationship: inverse_is_a HGNC:7943 ! NPR1
+relationship: inverse_is_a HGNC:7944 ! NPR2
+
+[Term]
+id: FPLX:000206
+name: GYS
+synonym: "glycogen synthase" EXACT []
+xref: BEL:"GYS Family"
+xref: IP:IPR008631
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4706 ! GYS1
+relationship: inverse_is_a HGNC:4707 ! GYS2
+
+[Term]
+id: FPLX:000207
+name: G-12
+synonym: "G(12)" EXACT []
+synonym: "G12 family" EXACT []
+synonym: "G12 proteins" EXACT []
+synonym: "G12" EXACT []
+xref: IP:IPR000469
+xref: RE:R-HSA-114547
+xref: RE:R-HSA-418570
+xref: RE:R-HSA-418572
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000208 ! G_12_alpha
+
+[Term]
+id: FPLX:000208
+name: G-12-alpha
+synonym: "G-protein alpha-12" EXACT []
+synonym: "G-protein α-12" EXACT []
+synonym: "Ga12" EXACT []
+synonym: "Galpha12" EXACT []
+synonym: "Gα12" EXACT []
+xref: IP:IPR000469
+xref: RE:R-HSA-114525
+xref: RE:R-HSA-418570
+xref: RE:R-HSA-418572
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000207 ! G_12
+relationship: inverse_is_a HGNC:4380 ! GNA12
+relationship: inverse_is_a HGNC:4381 ! GNA13
+
+[Term]
+id: FPLX:000209
+name: G-alpha
+synonym: "G_alpha" EXACT []
+synonym: "G_α" EXACT []
+xref: XFAM:PF00503
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000213 ! G_i_alpha
+relationship: inverse_is_a FPLX:000218 ! G_s_alpha
+relationship: inverse_is_a FPLX:000216 ! G_q_alpha
+relationship: inverse_is_a FPLX:000208 ! G_12_alpha
+
+[Term]
+id: FPLX:000210
+name: G-beta
+synonym: "G protein beta" EXACT []
+synonym: "G protein β" EXACT []
+synonym: "G-protein beta" EXACT []
+synonym: "G-protein β" EXACT []
+synonym: "Gbeta" EXACT []
+synonym: "Gβ" EXACT []
+xref: BEL:"GNB Family"
+xref: IP:IPR016346
+xref: RE:R-HSA-167409
+xref: RE:R-HSA-400093
+xref: RE:R-HSA-6814207
+xref: RE:R-HSA-6814413
+xref: RE:R-HSA-8850524
+xref: SIGNOR:SIGNOR-PF4
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4396 ! GNB1
+relationship: inverse_is_a HGNC:4398 ! GNB2
+relationship: inverse_is_a HGNC:4400 ! GNB3
+relationship: inverse_is_a HGNC:20731 ! GNB4
+relationship: inverse_is_a HGNC:4401 ! GNB5
+
+[Term]
+id: FPLX:000211
+name: G-gamma
+synonym: "G protein gamma subunit" EXACT []
+synonym: "G protein gamma" EXACT []
+synonym: "G protein γ subunit" EXACT []
+synonym: "G protein γ" EXACT []
+xref: BEL:"GNG Family"
+xref: IP:IPR001770
+xref: NEXTPROT-FAMILY:01400
+xref: RE:R-HSA-167442
+xref: RE:R-HSA-400062
+xref: SIGNOR:SIGNOR-PF3
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4402 ! GNG10
+relationship: inverse_is_a HGNC:4403 ! GNG11
+relationship: inverse_is_a HGNC:19663 ! GNG12
+relationship: inverse_is_a HGNC:14131 ! GNG13
+relationship: inverse_is_a HGNC:4404 ! GNG2
+relationship: inverse_is_a HGNC:4405 ! GNG3
+relationship: inverse_is_a HGNC:4407 ! GNG4
+relationship: inverse_is_a HGNC:4408 ! GNG5
+relationship: inverse_is_a HGNC:4410 ! GNG7
+relationship: inverse_is_a HGNC:19664 ! GNG8
+relationship: inverse_is_a HGNC:4411 ! GNGT1
+relationship: inverse_is_a HGNC:4412 ! GNGT2
+
+[Term]
+id: FPLX:000212
+name: G-i
+synonym: "Gi protein" EXACT []
+synonym: "Gi" EXACT []
+xref: BEL:"GNAI Family"
+xref: IP:IPR001408
+xref: RE:R-HSA-111864
+xref: RE:R-HSA-167410
+xref: RE:R-HSA-167413
+xref: RE:R-HSA-167438
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000213 ! G_i_alpha
+
+[Term]
+id: FPLX:000213
+name: G-i-alpha
+synonym: "G alphai" EXACT []
+synonym: "G αi" EXACT []
+synonym: "G-Protein alpha-i" EXACT []
+synonym: "G-Protein α-i" EXACT []
+synonym: "Galphai" EXACT []
+synonym: "Gi alpha subunit" EXACT []
+synonym: "Gi alpha" EXACT []
+synonym: "Gi α subunit" EXACT []
+synonym: "Gi α" EXACT []
+synonym: "Gαi" EXACT []
+xref: IP:IPR001408
+xref: NCIT:C19275
+xref: RE:R-HSA-111864
+xref: RE:R-HSA-167410
+xref: RE:R-HSA-167413
+xref: RE:R-HSA-167438
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000212 ! G_i
+relationship: inverse_is_a HGNC:4389 ! GNAO1
+relationship: inverse_is_a HGNC:4384 ! GNAI1
+relationship: inverse_is_a HGNC:4385 ! GNAI2
+relationship: inverse_is_a HGNC:4387 ! GNAI3
+relationship: inverse_is_a HGNC:4393 ! GNAT1
+relationship: inverse_is_a HGNC:4394 ! GNAT2
+relationship: inverse_is_a HGNC:22800 ! GNAT3
+relationship: inverse_is_a HGNC:4395 ! GNAZ
+
+[Term]
+id: FPLX:000214
+name: G-protein
+synonym: "G protein" EXACT []
+synonym: "G proteins" EXACT []
+xref: NCIT:C17458
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000212 ! G_i
+relationship: inverse_is_a FPLX:000217 ! G_s
+relationship: inverse_is_a FPLX:000215 ! G_q
+relationship: inverse_is_a FPLX:000207 ! G_12
+
+[Term]
+id: FPLX:000215
+name: G-q
+synonym: "G(q/11)" EXACT []
+synonym: "Gq/11" EXACT []
+xref: BEL:"GNA Gq Family"
+xref: IP:IPR000654
+xref: RE:R-HSA-114534
+xref: RE:R-HSA-114556
+xref: RE:R-HSA-374848
+xref: RE:R-HSA-399987
+xref: RE:R-HSA-399992
+xref: RE:R-HSA-400000
+xref: RE:R-HSA-400008
+xref: RE:R-HSA-749499
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000216 ! G_q_alpha
+
+[Term]
+id: FPLX:000216
+name: G-q-alpha
+synonym: "G alphaq" EXACT []
+synonym: "G αq" EXACT []
+synonym: "G-Protein alpha-q" EXACT []
+synonym: "G-Protein α-q" EXACT []
+synonym: "Galphaq" EXACT []
+synonym: "Gq alpha subunit" EXACT []
+synonym: "Gq alpha" EXACT []
+synonym: "Gq α subunit" EXACT []
+synonym: "Gq α" EXACT []
+synonym: "Gαq" EXACT []
+xref: IP:IPR000654
+xref: RE:R-HSA-114534
+xref: RE:R-HSA-114556
+xref: RE:R-HSA-374848
+xref: RE:R-HSA-399987
+xref: RE:R-HSA-399992
+xref: RE:R-HSA-400000
+xref: RE:R-HSA-400008
+xref: RE:R-HSA-749499
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000215 ! G_q
+relationship: inverse_is_a HGNC:4390 ! GNAQ
+relationship: inverse_is_a HGNC:4379 ! GNA11
+relationship: inverse_is_a HGNC:4382 ! GNA14
+relationship: inverse_is_a HGNC:4383 ! GNA15
+
+[Term]
+id: FPLX:000217
+name: G-s
+synonym: "G protein Gs" EXACT []
+synonym: "G protein(s)" EXACT []
+synonym: "G S protein" EXACT []
+synonym: "Gs family" EXACT []
+synonym: "Gs protein" EXACT []
+xref: BEL:"GNA Gs Family"
+is_a: FPLX:000214 ! G_protein
+relationship: has_part FPLX:000218 ! G_s_alpha
+
+[Term]
+id: FPLX:000218
+name: G-s-alpha
+synonym: "G alphaS" EXACT []
+synonym: "G αS" EXACT []
+synonym: "G-alpha(s)" EXACT []
+synonym: "G-AlphaS" EXACT []
+synonym: "G-Protein alpha-s" EXACT []
+synonym: "G-Protein α-s" EXACT []
+synonym: "G-α(s)" EXACT []
+synonym: "G-αS" EXACT []
+synonym: "GalphaS" EXACT []
+synonym: "Gs alpha subunit" EXACT []
+synonym: "Gs alpha" EXACT []
+synonym: "Gs α subunit" EXACT []
+synonym: "Gs α" EXACT []
+synonym: "GαS" EXACT []
+is_a: FPLX:000209 ! G_alpha
+relationship: part_of FPLX:000217 ! G_s
+relationship: inverse_is_a HGNC:4392 ! GNAS
+relationship: inverse_is_a HGNC:4388 ! GNAL
+
+[Term]
+id: FPLX:000219
+name: hCG
+synonym: "hCG" EXACT []
+xref: NCIT:C2275
+xref: RE:R-HSA-378941
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1885 ! CGA
+relationship: has_part HGNC:1886 ! CGB3
+
+[Term]
+id: FPLX:000220
+name: HDAC
+synonym: "HDAC" EXACT []
+synonym: "histone deacetylase" EXACT []
+synonym: "histone deacetylases" EXACT []
+xref: BEL:"HDAC Family"
+xref: ECCODE:3.5.1.98
+xref: IP:IPR003084
+xref: MEDSCAN:urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b
+xref: NCIT:C16682
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000221 ! HDAC_I
+relationship: inverse_is_a FPLX:000222 ! HDAC_II
+relationship: inverse_is_a FPLX:000223 ! HDAC_III
+relationship: inverse_is_a FPLX:000224 ! HDAC_IV
+
+[Term]
+id: FPLX:000221
+name: HDAC-I
+synonym: "Class I HDACs" EXACT []
+synonym: "class I HDACs" EXACT []
+synonym: "class I histone deacetylases" EXACT []
+xref: BEL:"HDAC Class I Family"
+xref: IP:IPR003084
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:4852 ! HDAC1
+relationship: inverse_is_a HGNC:4853 ! HDAC2
+relationship: inverse_is_a HGNC:4854 ! HDAC3
+relationship: inverse_is_a HGNC:13315 ! HDAC8
+
+[Term]
+id: FPLX:000222
+name: HDAC-II
+synonym: "class II HDACs" EXACT []
+synonym: "class II histone deacetylases" EXACT []
+xref: BEL:"HDAC Class II Family"
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:14063 ! HDAC4
+relationship: inverse_is_a HGNC:14068 ! HDAC5
+relationship: inverse_is_a HGNC:14067 ! HDAC7
+relationship: inverse_is_a HGNC:14065 ! HDAC9
+relationship: inverse_is_a HGNC:14064 ! HDAC6
+relationship: inverse_is_a HGNC:18128 ! HDAC10
+
+[Term]
+id: FPLX:000223
+name: HDAC-III
+synonym: "Class III HDACs" EXACT []
+synonym: "class III HDACs" EXACT []
+synonym: "class III histone deacetylases" EXACT []
+xref: IP:IPR003000
+xref: IP:IPR026590
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:14929 ! SIRT1
+relationship: inverse_is_a HGNC:10886 ! SIRT2
+relationship: inverse_is_a HGNC:14931 ! SIRT3
+relationship: inverse_is_a HGNC:14932 ! SIRT4
+relationship: inverse_is_a HGNC:14933 ! SIRT5
+relationship: inverse_is_a HGNC:14934 ! SIRT6
+relationship: inverse_is_a HGNC:14935 ! SIRT7
+
+[Term]
+id: FPLX:000224
+name: HDAC-IV
+synonym: "Class IV HDACs" EXACT []
+synonym: "class IV HDACs" EXACT []
+synonym: "class IV histone deacetylases" EXACT []
+is_a: FPLX:000220 ! HDAC
+relationship: inverse_is_a HGNC:19086 ! HDAC11
+
+[Term]
+id: FPLX:000225
+name: HDL
+synonym: "HDL" EXACT []
+synonym: "High-density lipoproteins" EXACT []
+xref: BEL:"HDL Complex"
+xref: GO:0034364
+xref: NCIT:C25186
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:399 ! ALB
+relationship: has_part HGNC:600 ! APOA1
+relationship: has_part HGNC:601 ! APOA2
+relationship: has_part HGNC:613 ! APOE
+relationship: has_part HGNC:2095 ! CLU
+
+[Term]
+id: FPLX:000226
+name: Hedgehog
+synonym: "Hedgehog family" EXACT []
+synonym: "hedgehog protein" EXACT []
+synonym: "hedgehog signaling proteins" EXACT []
+synonym: "Hedgehog" EXACT []
+synonym: "Hh" EXACT []
+xref: BEL:"Hedgehog Family"
+xref: IP:IPR000320
+xref: IP:IPR001657
+xref: IP:IPR001767
+xref: IP:IPR003586
+xref: IP:IPR003587
+xref: IP:IPR009045
+xref: IP:IPR028992
+xref: MEDSCAN:urn:agi-aopfc:0000587
+xref: NCIT:C120493
+xref: NEXTPROT-FAMILY:01729
+xref: RE:R-HSA-5358286
+xref: RE:R-HSA-5358318
+xref: RE:R-HSA-5358332
+xref: RE:R-HSA-5362382
+xref: RE:R-HSA-5362391
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:2865 ! DHH
+relationship: inverse_is_a HGNC:5956 ! IHH
+relationship: inverse_is_a HGNC:10848 ! SHH
+
+[Term]
+id: FPLX:000227
+name: Hemoglobin
+synonym: "hemoglobin" EXACT []
+xref: BEL:"Hemoglobin Complex"
+xref: MEDSCAN:urn:agi-protfc:hemoglobin
+xref: NCIT:C16676
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4823 ! HBA1
+relationship: has_part HGNC:4824 ! HBA2
+relationship: has_part HGNC:4827 ! HBB
+relationship: has_part HGNC:4829 ! HBD
+relationship: has_part HGNC:4830 ! HBE1
+relationship: has_part HGNC:4831 ! HBG1
+relationship: has_part HGNC:4832 ! HBG2
+relationship: has_part HGNC:4826 ! HBM
+relationship: has_part HGNC:4833 ! HBQ1
+relationship: has_part HGNC:4835 ! HBZ
+
+[Term]
+id: FPLX:000228
+name: HES
+synonym: "Hes gene family" EXACT []
+synonym: "Hes genes" EXACT []
+synonym: "HES" EXACT []
+synonym: "Hes" EXACT []
+xref: BEL:"HES Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5192 ! HES1
+relationship: inverse_is_a HGNC:16005 ! HES2
+relationship: inverse_is_a HGNC:26226 ! HES3
+relationship: inverse_is_a HGNC:24149 ! HES4
+relationship: inverse_is_a HGNC:19764 ! HES5
+relationship: inverse_is_a HGNC:18254 ! HES6
+relationship: inverse_is_a HGNC:15977 ! HES7
+
+[Term]
+id: FPLX:000229
+name: HIF
+synonym: "HIF" EXACT []
+synonym: "HIFs" EXACT []
+synonym: "hypoxia-inducible factors" EXACT []
+xref: NCIT:C113839
+xref: RE:R-HSA-1234130
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000231 ! HIF_alpha
+relationship: has_part FPLX:000232 ! HIF_beta
+
+[Term]
+id: FPLX:000230
+name: HIF1
+synonym: "HIF-1" EXACT []
+xref: MEDSCAN:urn:agi-complex:HIF-1
+xref: MEDSCAN:urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85
+xref: NCIT:C17690
+xref: XFAM:PF11413
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:4910 ! HIF1A
+relationship: has_part HGNC:700 ! ARNT
+
+[Term]
+id: FPLX:000231
+name: HIF-alpha
+synonym: "HIFalpha" EXACT []
+synonym: "Hifalpha" EXACT []
+synonym: "HIFα" EXACT []
+synonym: "Hifα" EXACT []
+xref: RE:R-HSA-1234147
+relationship: part_of FPLX:000229 ! HIF
+relationship: inverse_is_a HGNC:4910 ! HIF1A
+relationship: inverse_is_a HGNC:3374 ! EPAS1
+relationship: inverse_is_a HGNC:15825 ! HIF3A
+
+[Term]
+id: FPLX:000232
+name: HIF-beta
+synonym: "HIFbeta" EXACT []
+synonym: "Hifbeta" EXACT []
+synonym: "HIFβ" EXACT []
+synonym: "Hifβ" EXACT []
+xref: RE:R-HSA-8936837
+relationship: part_of FPLX:000229 ! HIF
+relationship: inverse_is_a HGNC:700 ! ARNT
+relationship: inverse_is_a HGNC:16876 ! ARNT2
+relationship: inverse_is_a HGNC:701 ! ARNTL
+
+[Term]
+id: FPLX:000233
+name: Histone
+synonym: "Histone" EXACT []
+synonym: "histone" EXACT []
+synonym: "histones" EXACT []
+xref: BEL:"Histone Family"
+xref: MEDSCAN:urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121
+xref: MEDSCAN:urn:agi-protfc:histone
+xref: MESH:D006657
+xref: NCIT:C16687
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000234 ! Histone_H1
+relationship: inverse_is_a FPLX:000235 ! Histone_H2A
+relationship: inverse_is_a FPLX:000236 ! Histone_H2B
+relationship: inverse_is_a FPLX:000237 ! Histone_H3
+relationship: inverse_is_a FPLX:000238 ! Histone_H4
+
+[Term]
+id: FPLX:000234
+name: Histone-H1
+synonym: "histone H1" EXACT []
+xref: BEL:"Histone H1 Family"
+xref: MEDSCAN:urn:agi-protfc:histone%20H1
+xref: NCIT:C16683
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a HGNC:4714 ! H1F0
+relationship: inverse_is_a HGNC:18463 ! H1FOO
+relationship: inverse_is_a HGNC:4722 ! H1FX
+relationship: inverse_is_a HGNC:4715 ! HIST1H1A
+relationship: inverse_is_a HGNC:4719 ! HIST1H1B
+relationship: inverse_is_a HGNC:4716 ! HIST1H1C
+relationship: inverse_is_a HGNC:4717 ! HIST1H1D
+relationship: inverse_is_a HGNC:4718 ! HIST1H1E
+relationship: inverse_is_a HGNC:4720 ! HIST1H1T
+relationship: inverse_is_a HGNC:24893 ! H1FNT
+
+[Term]
+id: FPLX:000235
+name: Histone-H2A
+synonym: "Histone 2A" EXACT []
+synonym: "Histone H2A" EXACT []
+synonym: "histone H2A" EXACT []
+xref: BEL:"Histone H2A Family"
+xref: MEDSCAN:urn:agi-protfc:histone%20H2A
+xref: NCIT:C16684
+xref: NEXTPROT-FAMILY:01762
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:H2A1_HUMAN ! P0C0S8
+relationship: inverse_is_a HGNC:22516 ! H2AFB1
+relationship: inverse_is_a UP:H2AB1_HUMAN ! P0C5Y9
+relationship: inverse_is_a HGNC:14456 ! H2AFJ
+relationship: inverse_is_a HGNC:20664 ! H2AFV
+relationship: inverse_is_a HGNC:4739 ! H2AFX
+relationship: inverse_is_a HGNC:4740 ! H2AFY
+relationship: inverse_is_a HGNC:14453 ! H2AFY2
+relationship: inverse_is_a HGNC:4741 ! H2AFZ
+relationship: inverse_is_a HGNC:18729 ! HIST1H2AA
+relationship: inverse_is_a HGNC:4733 ! HIST1H2AC
+relationship: inverse_is_a HGNC:4729 ! HIST1H2AD
+relationship: inverse_is_a HGNC:13671 ! HIST1H2AH
+relationship: inverse_is_a HGNC:4727 ! HIST1H2AJ
+relationship: inverse_is_a HGNC:20508 ! HIST2H2AB
+relationship: inverse_is_a HGNC:4738 ! HIST2H2AC
+relationship: inverse_is_a HGNC:20507 ! HIST3H2A
+relationship: inverse_is_a UP:H2A1B_HUMAN ! P04908
+relationship: inverse_is_a UP:H2A2A_HUMAN ! Q6FI13
+
+[Term]
+id: FPLX:000236
+name: Histone-H2B
+synonym: "H2B" EXACT []
+synonym: "histone H2B" EXACT []
+xref: BEL:"Histone H2B Family"
+xref: MEDSCAN:urn:agi-protfc:histone%20H2B
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:H2B1C_HUMAN ! P62807
+relationship: inverse_is_a HGNC:18730 ! HIST1H2BA
+relationship: inverse_is_a HGNC:4751 ! HIST1H2BB
+relationship: inverse_is_a HGNC:4747 ! HIST1H2BD
+relationship: inverse_is_a HGNC:4755 ! HIST1H2BH
+relationship: inverse_is_a HGNC:4761 ! HIST1H2BJ
+relationship: inverse_is_a HGNC:13954 ! HIST1H2BK
+relationship: inverse_is_a HGNC:4748 ! HIST1H2BL
+relationship: inverse_is_a HGNC:4750 ! HIST1H2BM
+relationship: inverse_is_a HGNC:4749 ! HIST1H2BN
+relationship: inverse_is_a HGNC:4758 ! HIST1H2BO
+relationship: inverse_is_a HGNC:20516 ! HIST2H2BC
+relationship: inverse_is_a HGNC:20517 ! HIST2H2BD
+relationship: inverse_is_a HGNC:4760 ! HIST2H2BE
+relationship: inverse_is_a HGNC:24700 ! HIST2H2BF
+relationship: inverse_is_a HGNC:20514 ! HIST3H2BB
+relationship: inverse_is_a HGNC:4762 ! H2BFS
+relationship: inverse_is_a HGNC:27867 ! H2BFM
+relationship: inverse_is_a HGNC:27252 ! H2BFWT
+
+[Term]
+id: FPLX:000237
+name: Histone-H3
+synonym: "H3" EXACT []
+synonym: "histone H3" EXACT []
+synonym: "histone-3" EXACT []
+xref: BEL:"Histone H3 Family"
+xref: IP:IPR000164
+xref: MEDSCAN:urn:agi-protfc:histone%20H3
+xref: NCIT:C16685
+xref: NEXTPROT-FAMILY:01764
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:H31_HUMAN ! P68431
+relationship: inverse_is_a UP:H32_HUMAN ! Q71DI3
+relationship: inverse_is_a HGNC:4778 ! HIST3H3
+relationship: inverse_is_a UP:H33_HUMAN ! P84243
+relationship: inverse_is_a HGNC:33164 ! H3F3C
+
+[Term]
+id: FPLX:000238
+name: Histone-H4
+synonym: "histone H4" EXACT []
+xref: BEL:"Histone H4 Family"
+xref: IP:IPR001951
+xref: MEDSCAN:urn:agi-protfc:histone%20H4
+xref: NCIT:C16686
+xref: NEXTPROT-FAMILY:01765
+is_a: FPLX:000233 ! Histone
+relationship: inverse_is_a UP:H4_HUMAN ! P62805
+relationship: inverse_is_a HGNC:4792 ! HIST1H4G
+
+[Term]
+id: FPLX:000239
+name: HLA-DR
+synonym: "HLA-DR" EXACT []
+xref: BEL:"HLA-DR Family"
+xref: NCIT:C16692
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4947 ! HLA-DRA
+relationship: inverse_is_a HGNC:4948 ! HLA-DRB1
+relationship: inverse_is_a HGNC:4951 ! HLA-DRB3
+relationship: inverse_is_a HGNC:4952 ! HLA-DRB4
+relationship: inverse_is_a HGNC:4953 ! HLA-DRB5
+
+[Term]
+id: FPLX:000240
+name: HMOX
+synonym: "haem oxygenase" EXACT []
+synonym: "heme oxygenase" EXACT []
+xref: BEL:"HMOX Family"
+xref: ECCODE:1.14.99.3
+xref: IP:IPR002051
+xref: IP:IPR016053
+xref: IP:IPR016084
+xref: IP:IPR018207
+xref: RE:R-HSA-189382
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5013 ! HMOX1
+relationship: inverse_is_a HGNC:5014 ! HMOX2
+
+[Term]
+id: FPLX:000241
+name: HSP90
+synonym: "HSP90" EXACT []
+synonym: "Hsp90" EXACT []
+xref: BEL:"HSP90 Family"
+xref: NCIT:C17766
+xref: XFAM:PF00183
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000242 ! HSP90A
+relationship: inverse_is_a HGNC:12028 ! HSP90B1
+relationship: inverse_is_a HGNC:16264 ! TRAP1
+
+[Term]
+id: FPLX:000242
+name: HSP90A
+synonym: "HSP90A" EXACT []
+xref: RE:R-HSA-3371429
+xref: RE:R-HSA-419619
+xref: RE:R-HSA-5082395
+xref: RE:R-HSA-5618088
+is_a: FPLX:000241 ! HSP90
+relationship: inverse_is_a FPLX:000243 ! HSP90AA
+relationship: inverse_is_a HGNC:5258 ! HSP90AB1
+
+[Term]
+id: FPLX:000243
+name: HSP90AA
+synonym: "HSP90AA" EXACT []
+xref: RE:R-HSA-1218829
+xref: RE:R-HSA-1221657
+xref: RE:R-HSA-5082406
+is_a: FPLX:000242 ! HSP90A
+relationship: inverse_is_a HGNC:5253 ! HSP90AA1
+
+[Term]
+id: FPLX:000244
+name: HSPA
+synonym: "Heat Shock Protein 70" EXACT []
+synonym: "HSP70" EXACT []
+synonym: "Hsp70" EXACT []
+xref: BEL:"HSPA Family"
+xref: XFAM:PF00012
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:19022 ! HSPA12A
+relationship: inverse_is_a HGNC:16193 ! HSPA12B
+relationship: inverse_is_a HGNC:11375 ! HSPA13
+relationship: inverse_is_a HGNC:29526 ! HSPA14
+relationship: inverse_is_a HGNC:5232 ! HSPA1A
+relationship: inverse_is_a HGNC:5233 ! HSPA1B
+relationship: inverse_is_a HGNC:5234 ! HSPA1L
+relationship: inverse_is_a HGNC:5235 ! HSPA2
+relationship: inverse_is_a HGNC:5237 ! HSPA4
+relationship: inverse_is_a HGNC:17041 ! HSPA4L
+relationship: inverse_is_a HGNC:5238 ! HSPA5
+relationship: inverse_is_a HGNC:5239 ! HSPA6
+relationship: inverse_is_a HGNC:5241 ! HSPA8
+relationship: inverse_is_a HGNC:5244 ! HSPA9
+relationship: inverse_is_a HGNC:16969 ! HSPH1
+relationship: inverse_is_a HGNC:16931 ! HYOU1
+
+[Term]
+id: FPLX:000245
+name: HSPB
+synonym: "heat shock protein family B" EXACT []
+synonym: "HSPB proteins" EXACT []
+synonym: "HSPB" EXACT []
+synonym: "small HSPs" EXACT []
+xref: BEL:"HSPB Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5246 ! HSPB1
+relationship: inverse_is_a HGNC:5247 ! HSPB2
+relationship: inverse_is_a HGNC:30171 ! HSPB8
+
+[Term]
+id: FPLX:000246
+name: IFNA
+synonym: "IFN-a" EXACT []
+synonym: "IFN-alpha" EXACT []
+synonym: "IFN-α" EXACT []
+synonym: "IFNalpha" EXACT []
+synonym: "IFNα" EXACT []
+xref: BEL:"IFNA Family"
+xref: RE:R-HSA-909688
+is_a: FPLX:000262 ! Interferon
+relationship: inverse_is_a HGNC:5417 ! IFNA1
+relationship: inverse_is_a HGNC:5423 ! IFNA2
+relationship: inverse_is_a HGNC:5425 ! IFNA4
+relationship: inverse_is_a HGNC:5426 ! IFNA5
+relationship: inverse_is_a HGNC:5427 ! IFNA6
+relationship: inverse_is_a HGNC:5428 ! IFNA7
+relationship: inverse_is_a HGNC:5429 ! IFNA8
+relationship: inverse_is_a HGNC:5418 ! IFNA10
+relationship: inverse_is_a HGNC:5419 ! IFNA13
+relationship: inverse_is_a HGNC:5420 ! IFNA14
+relationship: inverse_is_a HGNC:5421 ! IFNA16
+relationship: inverse_is_a HGNC:5422 ! IFNA17
+relationship: inverse_is_a HGNC:5424 ! IFNA21
+
+[Term]
+id: FPLX:000247
+name: IFNB
+synonym: "beta interferons" EXACT []
+synonym: "IFN-beta" EXACT []
+synonym: "IFN-β" EXACT []
+synonym: "Interferon beta" EXACT []
+synonym: "interferon beta" EXACT []
+synonym: "Interferon β" EXACT []
+synonym: "interferon β" EXACT []
+synonym: "β interferons" EXACT []
+xref: IP:IPR015588
+xref: NCIT:C20495
+is_a: FPLX:000262 ! Interferon
+relationship: inverse_is_a HGNC:5434 ! IFNB1
+
+[Term]
+id: FPLX:000248
+name: IGFBP
+synonym: "IGF-BP" EXACT []
+synonym: "IGFBP" EXACT []
+synonym: "IGFBPs" EXACT []
+synonym: "insulin-like growth factor binding proteins" EXACT []
+xref: BEL:"IGFBP Family"
+xref: MEDSCAN:urn:agi-aopfc:0000586
+xref: XFAM:PF00219
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5469 ! IGFBP1
+relationship: inverse_is_a HGNC:5471 ! IGFBP2
+relationship: inverse_is_a HGNC:5472 ! IGFBP3
+relationship: inverse_is_a HGNC:5473 ! IGFBP4
+relationship: inverse_is_a HGNC:5474 ! IGFBP5
+relationship: inverse_is_a HGNC:5475 ! IGFBP6
+relationship: inverse_is_a HGNC:5476 ! IGFBP7
+
+[Term]
+id: FPLX:000249
+name: IKB
+synonym: "IkappaB" EXACT []
+synonym: "IκB" EXACT []
+xref: NCIT:C17583
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000250
+name: IKK-complex
+synonym: "IKK complex" EXACT []
+xref: BEL:"IkappaB Kinase Complex"
+xref: MEDSCAN:urn:agi-complex:IKK%20complex
+xref: RE:R-HSA-1168621
+xref: RE:R-HSA-168113
+xref: RE:R-HSA-177663
+xref: RE:R-HSA-202513
+xref: RE:R-HSA-202562
+xref: RE:R-HSA-5262981
+xref: RE:R-HSA-727820
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1974 ! CHUK
+relationship: has_part HGNC:5960 ! IKBKB
+relationship: has_part HGNC:5961 ! IKBKG
+
+[Term]
+id: FPLX:000251
+name: IKK-family
+synonym: "IkappaB kinase" EXACT []
+synonym: "IKK" EXACT []
+synonym: "IκB kinase" EXACT []
+xref: BEL:"IkappaB Kinase Family"
+xref: NCIT:C104199
+xref: NEXTPROT-FAMILY:03104
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1974 ! CHUK
+relationship: inverse_is_a HGNC:5960 ! IKBKB
+relationship: inverse_is_a HGNC:5961 ! IKBKG
+relationship: inverse_is_a HGNC:14552 ! IKBKE
+relationship: inverse_is_a HGNC:11584 ! TBK1
+
+[Term]
+id: FPLX:000252
+name: IL1
+synonym: "IL-1" EXACT []
+synonym: "IL1 family" EXACT []
+xref: BEL:"IL1 Family"
+xref: IP:IPR003502
+xref: MEDSCAN:urn:agi-aopfc:0000615
+xref: NCIT:C20506
+xref: NEXTPROT-FAMILY:01820
+xref: XFAM:PF00340
+xref: RE:R-HSA-445744
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5991 ! IL1A
+relationship: inverse_is_a HGNC:5992 ! IL1B
+
+[Term]
+id: FPLX:000253
+name: IL12
+synonym: "IL-12" EXACT []
+synonym: "IL12" EXACT []
+xref: MEDSCAN:urn:agi-complex:IL12
+xref: NCIT:C20514
+xref: XFAM:PF03039
+xref: RE:R-HSA-447102
+xref: RE:R-HSA-8950122
+xref: RE:R-HSA-8950228
+xref: RE:R-HSA-8950694
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5969 ! IL12A
+relationship: inverse_is_a HGNC:5970 ! IL12B
+
+[Term]
+id: FPLX:000254
+name: IL15R
+synonym: "IL-15 receptor" EXACT []
+synonym: "IL-15R" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:5978 ! IL15RA
+relationship: has_part HGNC:6009 ! IL2RB
+relationship: has_part HGNC:6010 ! IL2RG
+
+[Term]
+id: FPLX:000255
+name: IL2R
+synonym: "IL-2 receptor" EXACT []
+synonym: "IL-2R" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:6008 ! IL2RA
+relationship: has_part HGNC:6009 ! IL2RB
+relationship: has_part HGNC:6010 ! IL2RG
+
+[Term]
+id: FPLX:000256
+name: Inhibin
+synonym: "Inhibin" EXACT []
+synonym: "inhibin" EXACT []
+xref: GO:0043511
+xref: NCIT:C2276
+xref: RE:R-HSA-1449688
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000257 ! Inhibin_A
+relationship: inverse_is_a FPLX:000258 ! Inhibin_B
+
+[Term]
+id: FPLX:000257
+name: Inhibin-A
+synonym: "inhibin A" EXACT []
+synonym: "inhibin-A" EXACT []
+synonym: "inhibin-a" EXACT []
+xref: MEDSCAN:urn:agi-complex:inhibin%20A
+xref: NCIT:C2277
+is_a: FPLX:000256 ! Inhibin
+relationship: has_part HGNC:6065 ! INHA
+relationship: has_part HGNC:6066 ! INHBA
+
+[Term]
+id: FPLX:000258
+name: Inhibin-B
+synonym: "inhibin B" EXACT []
+synonym: "inhibin-B" EXACT []
+synonym: "inhibin-b" EXACT []
+xref: NCIT:C2278
+is_a: FPLX:000256 ! Inhibin
+relationship: has_part HGNC:6065 ! INHA
+relationship: has_part HGNC:6067 ! INHBB
+
+[Term]
+id: FPLX:000259
+name: INS
+synonym: "insulin family" EXACT []
+xref: BEL:"INS Family"
+xref: NEXTPROT-FAMILY:01869
+xref: RE:R-HSA-429349
+xref: RE:R-HSA-429352
+xref: RE:R-HSA-429384
+xref: RE:R-HSA-429407
+xref: RE:R-HSA-429472
+xref: RE:R-HSA-74674
+xref: RE:R-HSA-77385
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6081 ! INS
+
+[Term]
+id: FPLX:000260
+name: INSR
+synonym: "Insulin receptor family" EXACT []
+synonym: "insulin receptor family" EXACT []
+synonym: "insulin receptor/insulin-like growth factor receptor family" EXACT []
+xref: BEL:"INSR Family"
+xref: IP:IPR016246
+xref: MEDSCAN:urn:agi-aopfc:0000264
+xref: NEXTPROT-FAMILY:03128
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5465 ! IGF1R
+relationship: inverse_is_a HGNC:6091 ! INSR
+relationship: inverse_is_a HGNC:6093 ! INSRR
+
+[Term]
+id: FPLX:000261
+name: Integrins
+synonym: "alpha2beta1 integrin" EXACT []
+synonym: "integrin" EXACT []
+synonym: "integrins" EXACT []
+synonym: "LFA-1 (integrin)" EXACT []
+synonym: "MAC-1 (integrin)" EXACT []
+synonym: "vitronectin receptor (integrin)" EXACT []
+xref: GO:0034666
+xref: GO:0034683
+xref: GO:0034687
+xref: MEDSCAN:urn:agi-complex:MAC-1%20(integrin)
+xref: NCIT:C16748
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000262
+name: Interferon
+synonym: "IFN" EXACT []
+synonym: "interferon" EXACT []
+xref: MEDSCAN:urn:agi-protfc:interferon
+xref: NCIT:C20493
+xref: XFAM:PF00143
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000246 ! IFNA
+relationship: inverse_is_a FPLX:000247 ! IFNB
+relationship: inverse_is_a HGNC:21714 ! IFNK
+relationship: inverse_is_a HGNC:5448 ! IFNW1
+
+[Term]
+id: FPLX:000263
+name: Interferon-gamma-receptor
+synonym: "IFNGR" EXACT []
+synonym: "interferon gamma receptor" EXACT []
+synonym: "interferon γ receptor" EXACT []
+synonym: "interferon-gamma receptor" EXACT []
+synonym: "interferon-γ receptor" EXACT []
+xref: BEL:"Interferon Gamma Receptor Complex"
+xref: MEDSCAN:urn:agi-complex:IFNGR
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:5439 ! IFNGR1
+relationship: has_part HGNC:5440 ! IFNGR2
+
+[Term]
+id: FPLX:000264
+name: IRS
+synonym: "insulin receptor substrate" EXACT []
+synonym: "IRS family" EXACT []
+synonym: "IRS" EXACT []
+xref: BEL:"IRS Family"
+xref: MEDSCAN:urn:agi-aopfc:0000585
+xref: XFAM:PF02174
+xref: RE:R-HSA-2445131
+xref: RE:R-HSA-2445139
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6125 ! IRS1
+relationship: inverse_is_a HGNC:6126 ! IRS2
+relationship: inverse_is_a HGNC:6128 ! IRS4
+
+[Term]
+id: FPLX:000265
+name: IRX
+synonym: "homeodomain iroquois proteins" EXACT []
+synonym: "Iroquois family" EXACT []
+synonym: "Iroquois proteins" EXACT []
+synonym: "Iroquois-class homeodomain proteins" EXACT []
+xref: BEL:"IRX Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:14358 ! IRX1
+relationship: inverse_is_a HGNC:14359 ! IRX2
+relationship: inverse_is_a HGNC:14360 ! IRX3
+relationship: inverse_is_a HGNC:6129 ! IRX4
+relationship: inverse_is_a HGNC:14361 ! IRX5
+relationship: inverse_is_a HGNC:14675 ! IRX6
+relationship: inverse_is_a HGNC:23729 ! MKX
+
+[Term]
+id: FPLX:000266
+name: JAK
+synonym: "JAK" EXACT []
+synonym: "Jak" EXACT []
+synonym: "JAKs" EXACT []
+xref: BEL:"JAK Family"
+xref: IP:IPR016251
+xref: MEDSCAN:urn:agi-aopfc:0000464
+xref: NEXTPROT-FAMILY:03129
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6190 ! JAK1
+relationship: inverse_is_a HGNC:6192 ! JAK2
+relationship: inverse_is_a HGNC:6193 ! JAK3
+relationship: inverse_is_a HGNC:12440 ! TYK2
+
+[Term]
+id: FPLX:000267
+name: JNK
+synonym: "c-JNK" EXACT []
+synonym: "c-Jun N-terminal kinase" EXACT []
+synonym: "c-Jun NH2-terminal kinase" EXACT []
+synonym: "JNK MAPK" EXACT []
+synonym: "JNK" EXACT []
+synonym: "JNK1/2" EXACT []
+synonym: "JNKs" EXACT []
+xref: BEL:"MAPK JNK Family"
+xref: IP:IPR008351
+xref: MEDSCAN:urn:agi-aopfc:0000473
+xref: RE:R-HSA-450226
+xref: RE:R-HSA-450253
+xref: RE:R-HSA-450289
+xref: SIGNOR:SIGNOR-PF15
+is_a: FPLX:000283 ! MAPK
+relationship: inverse_is_a HGNC:6881 ! MAPK8
+relationship: inverse_is_a HGNC:6886 ! MAPK9
+relationship: inverse_is_a HGNC:6872 ! MAPK10
+
+[Term]
+id: FPLX:000268
+name: JUN-family
+synonym: "JUN" EXACT []
+xref: IP:IPR002112
+xref: IP:IPR005643
+xref: MEDSCAN:urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75
+relationship: part_of FPLX:000048 ! AP1
+relationship: inverse_is_a HGNC:6204 ! JUN
+relationship: inverse_is_a HGNC:6205 ! JUNB
+relationship: inverse_is_a HGNC:6206 ! JUND
+
+[Term]
+id: FPLX:000269
+name: Kainate-family
+synonym: "Glutamate receptors, ionotropic, kainate" EXACT []
+synonym: "Kainate receptors" EXACT []
+synonym: "KARs" EXACT []
+xref: GFAM:1199
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4579 ! GRIK1
+relationship: inverse_is_a HGNC:4580 ! GRIK2
+relationship: inverse_is_a HGNC:4581 ! GRIK3
+relationship: inverse_is_a HGNC:4582 ! GRIK4
+relationship: inverse_is_a HGNC:4583 ! GRIK5
+
+[Term]
+id: FPLX:000270
+name: Kinetochore
+synonym: "kinetochore complex" EXACT []
+synonym: "kinetochore" EXACT []
+synonym: "kinetochores" EXACT []
+xref: BEL:"Kinetochore Complex"
+xref: GO:0000776
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1148 ! BUB1
+relationship: has_part HGNC:1149 ! BUB1B
+relationship: has_part HGNC:1151 ! BUB3
+relationship: has_part HGNC:1854 ! CENPC
+relationship: has_part HGNC:1856 ! CENPE
+relationship: has_part HGNC:1857 ! CENPF
+relationship: has_part HGNC:17268 ! CENPH
+relationship: has_part HGNC:2712 ! DCTN2
+relationship: has_part HGNC:6391 ! KIF22
+relationship: has_part HGNC:6763 ! MAD2L1
+relationship: has_part HGNC:8574 ! PAFAH1B1
+relationship: has_part HGNC:9508 ! PSEN1
+relationship: has_part HGNC:9509 ! PSEN2
+relationship: has_part HGNC:11111 ! SMC1A
+relationship: has_part HGNC:16987 ! SUGT1
+relationship: has_part HGNC:11124 ! SUMO3
+relationship: has_part HGNC:13194 ! ZW10
+
+[Term]
+id: FPLX:000271
+name: KLK
+synonym: "kallikrein" EXACT []
+synonym: "kallikrein-related peptidases" EXACT []
+synonym: "KLKs" EXACT []
+synonym: "tissue kallikrein" EXACT []
+synonym: "tissue kallikreins" EXACT []
+xref: BEL:"KLK Family"
+xref: ECCODE:3.4.21.35
+xref: MEDSCAN:urn:agi-protfc:kallikrein
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6357 ! KLK1
+relationship: inverse_is_a HGNC:6358 ! KLK10
+relationship: inverse_is_a HGNC:6359 ! KLK11
+relationship: inverse_is_a HGNC:6360 ! KLK12
+relationship: inverse_is_a HGNC:6361 ! KLK13
+relationship: inverse_is_a HGNC:6362 ! KLK14
+relationship: inverse_is_a HGNC:20453 ! KLK15
+relationship: inverse_is_a HGNC:6363 ! KLK2
+relationship: inverse_is_a HGNC:6364 ! KLK3
+relationship: inverse_is_a HGNC:6365 ! KLK4
+relationship: inverse_is_a HGNC:6366 ! KLK5
+relationship: inverse_is_a HGNC:6367 ! KLK6
+relationship: inverse_is_a HGNC:6368 ! KLK7
+relationship: inverse_is_a HGNC:6369 ! KLK8
+relationship: inverse_is_a HGNC:6370 ! KLK9
+relationship: inverse_is_a HGNC:6371 ! KLKB1
+
+[Term]
+id: FPLX:000272
+name: KSR
+synonym: "KSR" EXACT []
+xref: IP:IPR025561
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6465 ! KSR1
+relationship: inverse_is_a HGNC:18610 ! KSR2
+
+[Term]
+id: FPLX:000273
+name: Laminin-111
+synonym: "LM-1" EXACT []
+xref: BEL:"Laminin 1 Complex"
+xref: RE:R-HSA-215989
+xref: RE:R-HSA-2426371
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:6481 ! LAMA1
+relationship: has_part HGNC:6486 ! LAMB1
+relationship: has_part HGNC:6492 ! LAMC1
+
+[Term]
+id: FPLX:000274
+name: Laminin-332
+synonym: "laminin 332 chains" EXACT []
+synonym: "laminin 332" EXACT []
+synonym: "laminin-332 chains" EXACT []
+synonym: "laminin-332" EXACT []
+synonym: "Laminin-5" EXACT []
+synonym: "laminin-5" EXACT []
+xref: BEL:"Laminin 5 Complex"
+xref: GO:0005610
+xref: RE:R-HSA-216001
+xref: RE:R-HSA-2220790
+xref: RE:R-HSA-2399659
+xref: RE:R-HSA-2533911
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:6483 ! LAMA3
+relationship: has_part HGNC:6490 ! LAMB3
+relationship: has_part HGNC:6493 ! LAMC2
+
+[Term]
+id: FPLX:000275
+name: LDH
+synonym: "LDH" EXACT []
+xref: BEL:"LDH Family"
+xref: NCIT:C25184
+xref: NEXTPROT-FAMILY:02022
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6535 ! LDHA
+relationship: inverse_is_a HGNC:6541 ! LDHB
+relationship: inverse_is_a HGNC:6544 ! LDHC
+
+[Term]
+id: FPLX:000276
+name: LH
+synonym: "LH" EXACT []
+synonym: "Luteinizing hormone" EXACT []
+synonym: "luteinizing hormone" EXACT []
+synonym: "luteinizing-hormone" EXACT []
+xref: BEL:"Luteinizing Hormone Complex"
+xref: MEDSCAN:urn:agi-complex:Luteinizing%20hormone
+xref: RE:R-HSA-378969
+xref: RE:R-HSA-6793931
+xref: RE:R-HSA-6793934
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1885 ! CGA
+relationship: has_part HGNC:6584 ! LHB
+
+[Term]
+id: FPLX:000277
+name: LPAR
+xref: SIGNOR:SIGNOR-PF2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3166 ! LPAR1
+relationship: inverse_is_a HGNC:3168 ! LPAR2
+relationship: inverse_is_a HGNC:14298 ! LPAR3
+
+[Term]
+id: FPLX:000278
+name: MAC
+synonym: "MAC" EXACT []
+synonym: "membrane attack complex" EXACT []
+synonym: "membrane attack" EXACT []
+xref: BEL:"Membrane Attack Complex"
+xref: GO:0005579
+xref: RE:R-HSA-173728
+xref: RE:R-HSA-8852568
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1331 ! C5
+relationship: has_part HGNC:1339 ! C6
+relationship: has_part HGNC:1346 ! C7
+relationship: has_part HGNC:1352 ! C8A
+relationship: has_part HGNC:1353 ! C8B
+relationship: has_part HGNC:1354 ! C8G
+relationship: has_part HGNC:1358 ! C9
+
+[Term]
+id: FPLX:000279
+name: MAF
+synonym: "Maf subfamily" EXACT []
+synonym: "MAF" EXACT []
+synonym: "Maf" EXACT []
+synonym: "maf" EXACT []
+xref: BEL:"MAF Family"
+xref: IP:IPR004826
+xref: MEDSCAN:urn:agi-aopfc:0000142
+xref: XFAM:PF02545
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6776 ! MAF
+relationship: inverse_is_a HGNC:23145 ! MAFA
+relationship: inverse_is_a HGNC:6408 ! MAFB
+relationship: inverse_is_a HGNC:6780 ! MAFF
+relationship: inverse_is_a HGNC:6781 ! MAFG
+relationship: inverse_is_a HGNC:6782 ! MAFK
+
+[Term]
+id: FPLX:000280
+name: MAP1LC3
+synonym: "LC3" EXACT []
+xref: IP:IPR004241
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6838 ! MAP1LC3A
+relationship: inverse_is_a HGNC:13352 ! MAP1LC3B
+relationship: inverse_is_a HGNC:34390 ! MAP1LC3B2
+relationship: inverse_is_a HGNC:13353 ! MAP1LC3C
+
+[Term]
+id: FPLX:000281
+name: MAP2K
+synonym: "MAPK kinase" EXACT []
+synonym: "mitogen-activated protein kinase kinase" EXACT []
+xref: NCIT:C105947
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000286 ! MEK
+relationship: inverse_is_a HGNC:6843 ! MAP2K3
+relationship: inverse_is_a HGNC:6844 ! MAP2K4
+relationship: inverse_is_a HGNC:6845 ! MAP2K5
+relationship: inverse_is_a HGNC:6846 ! MAP2K6
+relationship: inverse_is_a HGNC:6847 ! MAP2K7
+
+[Term]
+id: FPLX:000282
+name: MAP3K
+synonym: "MAP3K" EXACT []
+synonym: "MAPK kinase kinase" EXACT []
+synonym: "MAPKK kinases" EXACT []
+synonym: "MAPKKK" EXACT []
+xref: ECCODE:2.7.11.25
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000399 ! RAF
+relationship: inverse_is_a HGNC:6848 ! MAP3K1
+relationship: inverse_is_a HGNC:6854 ! MAP3K2
+relationship: inverse_is_a HGNC:6855 ! MAP3K3
+relationship: inverse_is_a HGNC:6856 ! MAP3K4
+relationship: inverse_is_a HGNC:6857 ! MAP3K5
+relationship: inverse_is_a HGNC:6858 ! MAP3K6
+relationship: inverse_is_a HGNC:6859 ! MAP3K7
+relationship: inverse_is_a HGNC:6860 ! MAP3K8
+relationship: inverse_is_a HGNC:6861 ! MAP3K9
+relationship: inverse_is_a HGNC:6849 ! MAP3K10
+relationship: inverse_is_a HGNC:6850 ! MAP3K11
+relationship: inverse_is_a HGNC:6851 ! MAP3K12
+relationship: inverse_is_a HGNC:6852 ! MAP3K13
+relationship: inverse_is_a HGNC:6853 ! MAP3K14
+relationship: inverse_is_a HGNC:31689 ! MAP3K15
+relationship: inverse_is_a FPLX:000458 ! TAOK
+relationship: inverse_is_a HGNC:26249 ! MAP3K19
+relationship: inverse_is_a HGNC:17797 ! MAP3K20
+relationship: inverse_is_a HGNC:29798 ! MAP3K21
+
+[Term]
+id: FPLX:000283
+name: MAPK
+synonym: "MAP kinase" EXACT []
+synonym: "MAP kinases" EXACT []
+synonym: "MAPKs" EXACT []
+synonym: "mitogen activated protein kinase" EXACT []
+synonym: "mitogen activated protein kinases" EXACT []
+synonym: "mitogen-activated protein kinase" EXACT []
+synonym: "mitogen-activated protein kinases" EXACT []
+xref: ECCODE:2.7.11.24
+xref: ECCODE:2.7.12.2
+xref: NCIT:C16376
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000161 ! ERK
+relationship: inverse_is_a FPLX:000326 ! p38
+relationship: inverse_is_a FPLX:000267 ! JNK
+
+[Term]
+id: FPLX:000284
+name: MCM
+synonym: "MCM" EXACT []
+synonym: "mini-chromosome maintenance complex" EXACT []
+synonym: "minichromosome maintenance complex" EXACT []
+synonym: "minichromosome maintenance protein complex" EXACT []
+xref: GO:0042555
+xref: IP:IPR001208
+xref: IP:IPR031327
+xref: MEDSCAN:urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1
+xref: NEXTPROT-FAMILY:02187
+xref: XFAM:PF00493
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6944 ! MCM2
+relationship: inverse_is_a HGNC:6945 ! MCM3
+relationship: inverse_is_a HGNC:6947 ! MCM4
+relationship: inverse_is_a HGNC:6948 ! MCM5
+relationship: inverse_is_a HGNC:6949 ! MCM6
+relationship: inverse_is_a HGNC:6950 ! MCM7
+relationship: inverse_is_a HGNC:16147 ! MCM8
+relationship: inverse_is_a HGNC:21484 ! MCM9
+relationship: inverse_is_a HGNC:26368 ! MCMDC2
+
+[Term]
+id: FPLX:000285
+name: MEF2
+synonym: "MEF2 family" EXACT []
+synonym: "MEF2" EXACT []
+xref: BEL:"MEF2 Family"
+xref: IP:IPR033896
+xref: MEDSCAN:urn:agi-aopfc:0000143
+xref: RE:R-HSA-448866
+xref: RE:R-HSA-448868
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6993 ! MEF2A
+relationship: inverse_is_a HGNC:6996 ! MEF2C
+relationship: inverse_is_a HGNC:6997 ! MEF2D
+relationship: inverse_is_a HGNC:6995 ! MEF2B
+
+[Term]
+id: FPLX:000286
+name: MEK
+synonym: "MEK 1/2" EXACT []
+synonym: "MEK" EXACT []
+synonym: "MEK1/2" EXACT []
+xref: BEL:"MEK1/2 Family"
+xref: MEDSCAN:urn:agi-aopfc:0000462
+xref: RE:R-HSA-5672686
+xref: RE:R-HSA-5672705
+xref: RE:R-HSA-5672716
+xref: RE:R-HSA-5672721
+xref: RE:R-HSA-5674489
+xref: SIGNOR:SIGNOR-PF25
+is_a: FPLX:000281 ! MAP2K
+relationship: inverse_is_a HGNC:6840 ! MAP2K1
+relationship: inverse_is_a HGNC:6842 ! MAP2K2
+
+[Term]
+id: FPLX:000287
+name: MGAT
+synonym: "MGAT" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:7044 ! MGAT1
+relationship: inverse_is_a HGNC:7045 ! MGAT2
+relationship: inverse_is_a HGNC:7046 ! MGAT3
+relationship: inverse_is_a HGNC:7047 ! MGAT4A
+relationship: inverse_is_a HGNC:7048 ! MGAT4B
+relationship: inverse_is_a HGNC:30871 ! MGAT4C
+relationship: inverse_is_a HGNC:43619 ! MGAT4D
+relationship: inverse_is_a HGNC:7049 ! MGAT5
+relationship: inverse_is_a HGNC:24140 ! MGAT5B
+
+[Term]
+id: FPLX:000288
+name: Mitochondrial-Ribosome
+synonym: "mammalian mitochondrial ribosome" EXACT []
+synonym: "Mitochondrial ribosome" EXACT []
+synonym: "Mitochondrial Ribosome" EXACT []
+synonym: "mitochondrial ribosomes" EXACT []
+synonym: "Mitochondrial ribosomes" EXACT []
+synonym: "Mitochondrial Ribosomes" EXACT []
+synonym: "mitoribosome" EXACT []
+synonym: "Mitoribosome" EXACT []
+synonym: "55S mammalian mitochondrial ribosome" EXACT []
+synonym: "55S mitoribosome" EXACT []
+synonym: "55s mitoribosome" EXACT []
+synonym: "55S Mitoribosome" EXACT []
+synonym: "55s Mitoribosome" EXACT []
+xref: GO:0005761
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000289 ! MRPS
+relationship: has_part FPLX:000290 ! MRPL
+
+[Term]
+id: FPLX:000289
+name: MRPS
+synonym: "small mitoribosomal subunit" EXACT []
+synonym: "Small Mitoribosomal Subunit" EXACT []
+synonym: "small subunit of the mammalian mitochondrial ribosome" EXACT []
+synonym: "mitochondrial ribosomal small subunit" EXACT []
+xref: GO:0005763
+relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome
+relationship: has_part HGNC:14495 ! MRPS2
+relationship: has_part HGNC:14498 ! MRPS5
+relationship: has_part HGNC:14051 ! MRPS6
+relationship: has_part HGNC:14499 ! MRPS7
+relationship: has_part HGNC:14501 ! MRPS9
+relationship: has_part HGNC:14502 ! MRPS10
+relationship: has_part HGNC:14050 ! MRPS11
+relationship: has_part HGNC:10380 ! MRPS12
+relationship: has_part HGNC:14049 ! MRPS14
+relationship: has_part HGNC:14504 ! MRPS15
+relationship: has_part HGNC:14048 ! MRPS16
+relationship: has_part HGNC:14047 ! MRPS17
+relationship: has_part HGNC:14515 ! MRPS18A
+relationship: has_part HGNC:14516 ! MRPS18B
+relationship: has_part HGNC:16633 ! MRPS18C
+relationship: has_part HGNC:14046 ! MRPS21
+relationship: has_part HGNC:14508 ! MRPS22
+relationship: has_part HGNC:14509 ! MRPS23
+relationship: has_part HGNC:14510 ! MRPS24
+relationship: has_part HGNC:14511 ! MRPS25
+relationship: has_part HGNC:14045 ! MRPS26
+relationship: has_part HGNC:14512 ! MRPS27
+relationship: has_part HGNC:14513 ! MRPS28
+relationship: has_part HGNC:2673 ! DAP3
+relationship: has_part HGNC:8769 ! MRPS30
+relationship: has_part HGNC:16632 ! MRPS31
+relationship: has_part HGNC:16634 ! MRPS33
+relationship: has_part HGNC:16618 ! MRPS34
+relationship: has_part HGNC:16635 ! MRPS35
+relationship: has_part HGNC:16631 ! MRPS36
+
+[Term]
+id: FPLX:000290
+name: MRPL
+synonym: "large mitoribosomal subunit" EXACT []
+synonym: "Large Mitoribosomal Subunit" EXACT []
+synonym: "large subunit of the mammalian mitochondrial ribosome" EXACT []
+synonym: "mitochondrial ribosomal large subunit" EXACT []
+xref: GO:0005762
+relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome
+relationship: has_part HGNC:14275 ! MRPL1
+relationship: has_part HGNC:14056 ! MRPL2
+relationship: has_part HGNC:10379 ! MRPL3
+relationship: has_part HGNC:14276 ! MRPL4
+relationship: has_part HGNC:14277 ! MRPL9
+relationship: has_part HGNC:14055 ! MRPL10
+relationship: has_part HGNC:14042 ! MRPL11
+relationship: has_part HGNC:10378 ! MRPL12
+relationship: has_part HGNC:14278 ! MRPL13
+relationship: has_part HGNC:14279 ! MRPL14
+relationship: has_part HGNC:14054 ! MRPL15
+relationship: has_part HGNC:14476 ! MRPL16
+relationship: has_part HGNC:14053 ! MRPL17
+relationship: has_part HGNC:14477 ! MRPL18
+relationship: has_part HGNC:14052 ! MRPL19
+relationship: has_part HGNC:14478 ! MRPL20
+relationship: has_part HGNC:14479 ! MRPL21
+relationship: has_part HGNC:14480 ! MRPL22
+relationship: has_part HGNC:10322 ! MRPL23
+relationship: has_part HGNC:14037 ! MRPL24
+relationship: has_part HGNC:14483 ! MRPL27
+relationship: has_part HGNC:14484 ! MRPL28
+relationship: has_part HGNC:14036 ! MRPL30
+relationship: has_part HGNC:14035 ! MRPL32
+relationship: has_part HGNC:14487 ! MRPL33
+relationship: has_part HGNC:14488 ! MRPL34
+relationship: has_part HGNC:14489 ! MRPL35
+relationship: has_part HGNC:14490 ! MRPL36
+relationship: has_part HGNC:14034 ! MRPL37
+relationship: has_part HGNC:14033 ! MRPL38
+relationship: has_part HGNC:14027 ! MRPL39
+relationship: has_part HGNC:14491 ! MRPL40
+relationship: has_part HGNC:14492 ! MRPL41
+relationship: has_part HGNC:14493 ! MRPL42
+relationship: has_part HGNC:14517 ! MRPL43
+relationship: has_part HGNC:16650 ! MRPL44
+relationship: has_part HGNC:16651 ! MRPL45
+relationship: has_part HGNC:1192 ! MRPL46
+relationship: has_part HGNC:16652 ! MRPL47
+relationship: has_part HGNC:16653 ! MRPL48
+relationship: has_part HGNC:1176 ! MRPL49
+relationship: has_part HGNC:16654 ! MRPL50
+relationship: has_part HGNC:14044 ! MRPL51
+relationship: has_part HGNC:16655 ! MRPL52
+relationship: has_part HGNC:16684 ! MRPL53
+relationship: has_part HGNC:16685 ! MRPL54
+relationship: has_part HGNC:16686 ! MRPL55
+relationship: has_part HGNC:14514 ! MRPL57
+
+[Term]
+id: FPLX:000291
+name: MMP
+synonym: "MMP" EXACT []
+synonym: "MMPs" EXACT []
+xref: BEL:"MMP Family"
+xref: NCIT:C18164
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7155 ! MMP1
+relationship: inverse_is_a HGNC:7166 ! MMP2
+relationship: inverse_is_a HGNC:7173 ! MMP3
+relationship: inverse_is_a HGNC:7174 ! MMP7
+relationship: inverse_is_a HGNC:7175 ! MMP8
+relationship: inverse_is_a HGNC:7176 ! MMP9
+relationship: inverse_is_a HGNC:7156 ! MMP10
+relationship: inverse_is_a HGNC:7157 ! MMP11
+relationship: inverse_is_a HGNC:7158 ! MMP12
+relationship: inverse_is_a HGNC:7159 ! MMP13
+relationship: inverse_is_a HGNC:7160 ! MMP14
+relationship: inverse_is_a HGNC:7161 ! MMP15
+relationship: inverse_is_a HGNC:7162 ! MMP16
+relationship: inverse_is_a HGNC:7163 ! MMP17
+relationship: inverse_is_a HGNC:7165 ! MMP19
+relationship: inverse_is_a HGNC:7167 ! MMP20
+relationship: inverse_is_a HGNC:14357 ! MMP21
+relationship: inverse_is_a HGNC:7171 ! MMP23B
+relationship: inverse_is_a HGNC:7172 ! MMP24
+relationship: inverse_is_a HGNC:14246 ! MMP25
+relationship: inverse_is_a HGNC:14249 ! MMP26
+relationship: inverse_is_a HGNC:14250 ! MMP27
+relationship: inverse_is_a HGNC:14366 ! MMP28
+
+[Term]
+id: FPLX:000292
+name: Metallothionein
+synonym: "Metallothionein" EXACT []
+synonym: "metallothionein" EXACT []
+synonym: "MT" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7393 ! MT1A
+relationship: inverse_is_a HGNC:7394 ! MT1B
+relationship: inverse_is_a HGNC:7395 ! MT1CP
+relationship: inverse_is_a HGNC:7396 ! MT1DP
+relationship: inverse_is_a HGNC:7397 ! MT1E
+relationship: inverse_is_a HGNC:7398 ! MT1F
+relationship: inverse_is_a HGNC:7399 ! MT1G
+relationship: inverse_is_a HGNC:7400 ! MT1H
+relationship: inverse_is_a HGNC:31864 ! MT1HL1
+relationship: inverse_is_a HGNC:7401 ! MT1IP
+relationship: inverse_is_a HGNC:7402 ! MT1JP
+relationship: inverse_is_a HGNC:7404 ! MT1L
+relationship: inverse_is_a HGNC:14296 ! MT1M
+relationship: inverse_is_a HGNC:23681 ! MT1P1
+relationship: inverse_is_a HGNC:16120 ! MT1P3
+relationship: inverse_is_a HGNC:7405 ! MT1X
+relationship: inverse_is_a HGNC:7406 ! MT2A
+relationship: inverse_is_a HGNC:7408 ! MT3
+relationship: inverse_is_a HGNC:18705 ! MT4
+
+[Term]
+id: FPLX:000293
+name: mTORC1
+synonym: "mTORC1" EXACT []
+synonym: "TORC1" EXACT []
+xref: GO:0031931
+xref: MEDSCAN:urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e
+xref: NCIT:C96314
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3942 ! MTOR
+relationship: has_part HGNC:30287 ! RPTOR
+
+[Term]
+id: FPLX:000294
+name: mTORC2
+synonym: "mTORC2" EXACT []
+synonym: "TORC2" EXACT []
+xref: BEL:"TORC2 Complex"
+xref: MEDSCAN:urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168
+xref: NCIT:C96315
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:18752 ! MAPKAP1
+relationship: has_part HGNC:3942 ! MTOR
+relationship: has_part HGNC:28611 ! RICTOR
+relationship: has_part HGNC:24825 ! MLST8
+
+[Term]
+id: FPLX:000295
+name: MYH
+synonym: "myosin heavy chain genes" EXACT []
+synonym: "myosin heavy chain isoforms" EXACT []
+synonym: "myosin heavy chain protein" EXACT []
+synonym: "Myosin heavy chain" EXACT []
+synonym: "myosin heavy chain" EXACT []
+synonym: "Myosin heavy chains" EXACT []
+synonym: "myosin heavy chains" EXACT []
+xref: BEL:"MYH Family"
+xref: MEDSCAN:urn:agi-protfc:myosin%20heavy%20chain
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7567 ! MYH1
+relationship: inverse_is_a HGNC:7568 ! MYH10
+relationship: inverse_is_a HGNC:7569 ! MYH11
+relationship: inverse_is_a HGNC:7571 ! MYH13
+relationship: inverse_is_a HGNC:23212 ! MYH14
+relationship: inverse_is_a HGNC:31073 ! MYH15
+relationship: inverse_is_a HGNC:7572 ! MYH2
+relationship: inverse_is_a HGNC:7573 ! MYH3
+relationship: inverse_is_a HGNC:7574 ! MYH4
+relationship: inverse_is_a HGNC:7576 ! MYH6
+relationship: inverse_is_a HGNC:7577 ! MYH7
+relationship: inverse_is_a HGNC:15906 ! MYH7B
+relationship: inverse_is_a HGNC:7578 ! MYH8
+relationship: inverse_is_a HGNC:7579 ! MYH9
+relationship: inverse_is_a HGNC:7602 ! MYO5A
+
+[Term]
+id: FPLX:000296
+name: MYL
+synonym: "MLC" EXACT []
+synonym: "myosin light chain protein" EXACT []
+synonym: "myosin light chain" EXACT []
+synonym: "myosin light chains" EXACT []
+xref: BEL:"MYL Family"
+xref: MEDSCAN:urn:agi-protfc:myosin%20light%20chain
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000297 ! MYL_alkali
+relationship: inverse_is_a FPLX:000298 ! MYL_regulatory
+relationship: inverse_is_a FPLX:000299 ! MYL_slow
+
+[Term]
+id: FPLX:000297
+name: MYL-alkali
+synonym: "alkali myosin light chains" EXACT []
+synonym: "AMLC" EXACT []
+synonym: "myosin alkali light chain proteins" EXACT []
+synonym: "myosin alkali light chain" EXACT []
+xref: BEL:"MYL Alkali Family"
+is_a: FPLX:000296 ! MYL
+relationship: inverse_is_a HGNC:7582 ! MYL1
+relationship: inverse_is_a HGNC:7584 ! MYL3
+relationship: inverse_is_a HGNC:7585 ! MYL4
+relationship: inverse_is_a HGNC:7587 ! MYL6
+relationship: inverse_is_a HGNC:29823 ! MYL6B
+
+[Term]
+id: FPLX:000298
+name: MYL-regulatory
+synonym: "regulatory myosin light chain" EXACT []
+xref: BEL:"MYL Regulatory Family"
+is_a: FPLX:000296 ! MYL
+relationship: inverse_is_a HGNC:29825 ! MYL10
+relationship: inverse_is_a HGNC:16701 ! MYL12A
+relationship: inverse_is_a HGNC:29827 ! MYL12B
+relationship: inverse_is_a HGNC:7583 ! MYL2
+relationship: inverse_is_a HGNC:7586 ! MYL5
+relationship: inverse_is_a HGNC:21719 ! MYL7
+relationship: inverse_is_a HGNC:15754 ! MYL9
+relationship: inverse_is_a HGNC:29824 ! MYLPF
+
+[Term]
+id: FPLX:000299
+name: MYL-slow
+synonym: "slow myosin" EXACT []
+xref: BEL:"MYL Slow Family"
+is_a: FPLX:000296 ! MYL
+relationship: inverse_is_a HGNC:7583 ! MYL2
+relationship: inverse_is_a HGNC:7584 ! MYL3
+relationship: inverse_is_a HGNC:29823 ! MYL6B
+
+[Term]
+id: FPLX:000300
+name: MYST
+synonym: "MYST family" EXACT []
+synonym: "MYST histone acetylase" EXACT []
+synonym: "MYST proteins" EXACT []
+xref: BEL:"MYST Family"
+xref: IP:IPR002717
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:17933 ! KAT8
+relationship: inverse_is_a HGNC:17016 ! KAT7
+relationship: inverse_is_a HGNC:13013 ! KAT6A
+relationship: inverse_is_a HGNC:17582 ! KAT6B
+relationship: inverse_is_a HGNC:5275 ! KAT5
+
+[Term]
+id: FPLX:000301
+name: NADH-dehydrogenase
+synonym: "NADH dehydrogenase (ubiquinone)" EXACT []
+synonym: "NADH dehydrogenase" EXACT []
+xref: BEL:"NADH Dehydrogenase Complex"
+xref: ECCODE:1.6.5.3
+xref: XFAM:PF00146
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:7455 ! MT-ND1
+relationship: has_part HGNC:7456 ! MT-ND2
+relationship: has_part HGNC:7458 ! MT-ND3
+relationship: has_part HGNC:7459 ! MT-ND4
+relationship: has_part HGNC:7460 ! MT-ND4L
+relationship: has_part HGNC:7461 ! MT-ND5
+relationship: has_part HGNC:7462 ! MT-ND6
+
+[Term]
+id: FPLX:000302
+name: NADPH-oxidase
+synonym: "NAD(P)H oxidase" EXACT []
+synonym: "NAD(P)H-oxidase" EXACT []
+synonym: "NADPH oxidase" EXACT []
+xref: BEL:"NADPH Oxidase Complex"
+xref: MEDSCAN:urn:agi-aopfc:0000479
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2577 ! CYBA
+relationship: has_part HGNC:2578 ! CYBB
+relationship: has_part HGNC:3062 ! DUOX1
+relationship: has_part HGNC:13273 ! DUOX2
+relationship: has_part HGNC:7660 ! NCF1
+relationship: has_part HGNC:7661 ! NCF2
+relationship: has_part HGNC:7662 ! NCF4
+relationship: has_part HGNC:7889 ! NOX1
+relationship: has_part HGNC:7890 ! NOX3
+relationship: has_part HGNC:7891 ! NOX4
+relationship: has_part HGNC:14874 ! NOX5
+relationship: has_part HGNC:9801 ! RAC1
+
+[Term]
+id: FPLX:000303
+name: Na-K-ATPase
+synonym: "Na(+),K(+)-ATPase" EXACT []
+synonym: "Na,K-ATPase" EXACT []
+synonym: "Na+/K+-exchanging ATPase" EXACT []
+synonym: "Na+/K+ATPase" EXACT []
+synonym: "Na/K-ATPase" EXACT []
+xref: BEL:"Na/K Exchanging ATPase Complex"
+xref: ECCODE:3.6.3.9
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000057 ! ATP1A
+relationship: has_part FPLX:000058 ! ATP1B
+
+[Term]
+id: FPLX:000304
+name: Natriuretic-peptide
+synonym: "Natriuretic Peptide" EXACT []
+synonym: "Natriuretic peptide" EXACT []
+synonym: "natriuretic peptide" EXACT []
+synonym: "Natriuretic Peptides" EXACT []
+synonym: "Natriuretic peptides" EXACT []
+synonym: "natriuretic peptides" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7939 ! NPPA
+relationship: inverse_is_a HGNC:7940 ! NPPB
+relationship: inverse_is_a HGNC:7941 ! NPPC
+
+[Term]
+id: FPLX:000305
+name: NCOA
+synonym: "p160/SRC" EXACT []
+xref: BEL:"p160/SRC Family"
+xref: IP:IPR010011
+xref: IP:IPR014920
+xref: IP:IPR014935
+xref: IP:IPR017426
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7668 ! NCOA1
+relationship: inverse_is_a HGNC:7669 ! NCOA2
+relationship: inverse_is_a HGNC:7670 ! NCOA3
+
+[Term]
+id: FPLX:000306
+name: NCOR
+synonym: "Nuclear Receptor Co-Repressor" EXACT []
+synonym: "nuclear receptor co-repressor" EXACT []
+synonym: "Nuclear receptor corepressor" EXACT []
+synonym: "nuclear receptor corepressor" EXACT []
+xref: BEL:"NCOR Family"
+xref: RE:R-HSA-349716
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7672 ! NCOR1
+relationship: inverse_is_a HGNC:7673 ! NCOR2
+
+[Term]
+id: FPLX:000307
+name: NDRG
+synonym: "N-myc downstream regulated gene family" EXACT []
+synonym: "NDR family" EXACT []
+synonym: "NDR-family" EXACT []
+xref: BEL:"NDRG Family"
+xref: IP:IPR004142
+xref: XFAM:PF03096
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7679 ! NDRG1
+relationship: inverse_is_a HGNC:14460 ! NDRG2
+relationship: inverse_is_a HGNC:14462 ! NDRG3
+relationship: inverse_is_a HGNC:14466 ! NDRG4
+
+[Term]
+id: FPLX:000308
+name: Neurexins
+synonym: "Neurexins" EXACT []
+synonym: "NRXN" EXACT []
+xref: GFAM:1582
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8008 ! NRXN1
+relationship: inverse_is_a HGNC:8009 ! NRXN2
+relationship: inverse_is_a HGNC:8010 ! NRXN3
+
+[Term]
+id: FPLX:000309
+name: NFAT
+synonym: "NFAT" EXACT []
+xref: BEL:"NFAT Family"
+xref: IP:IPR008366
+xref: NCIT:C17903
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7775 ! NFATC1
+relationship: inverse_is_a HGNC:7776 ! NFATC2
+relationship: inverse_is_a HGNC:7777 ! NFATC3
+relationship: inverse_is_a HGNC:7778 ! NFATC4
+relationship: inverse_is_a HGNC:7774 ! NFAT5
+
+[Term]
+id: FPLX:000310
+name: NFE
+synonym: "NF-E2" EXACT []
+synonym: "NF-E2-related factor" EXACT []
+synonym: "Nuclear factor erythroid 2-related factor" EXACT []
+xref: MEDSCAN:urn:agi-aopfc:0000150
+xref: MEDSCAN:urn:agi-complex:NF-E2
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7781 ! NFE2L1
+relationship: inverse_is_a HGNC:7782 ! NFE2L2
+relationship: inverse_is_a HGNC:7783 ! NFE2L3
+
+[Term]
+id: FPLX:000311
+name: NFkappaB
+synonym: "NF-kappaB complexes" EXACT []
+synonym: "NF-kappaB dimers" EXACT []
+synonym: "NF-kappaB Factors" EXACT []
+synonym: "NF-kappaB factors" EXACT []
+synonym: "NF-kappaB genes" EXACT []
+synonym: "NF-kappaB subunits" EXACT []
+synonym: "NF-kappaB TFs" EXACT []
+synonym: "NF-kappaB" EXACT []
+synonym: "NF-kappabeta" EXACT []
+synonym: "NF-kappaBs" EXACT []
+synonym: "NF-kB" EXACT []
+synonym: "NF-κB complexes" EXACT []
+synonym: "NF-κB dimers" EXACT []
+synonym: "NF-κB Factors" EXACT []
+synonym: "NF-κB factors" EXACT []
+synonym: "NF-κB genes" EXACT []
+synonym: "NF-κB subunits" EXACT []
+synonym: "NF-κB TFs" EXACT []
+synonym: "NF-κB" EXACT []
+synonym: "NF-κBs" EXACT []
+synonym: "NF-κβ" EXACT []
+synonym: "NFkappaB complexes" EXACT []
+synonym: "NFkappaB" EXACT []
+synonym: "NFκB complexes" EXACT []
+synonym: "NFκB" EXACT []
+xref: BEL:"Nfkb Complex"
+xref: IP:IPR000451
+xref: IP:IPR030492
+xref: IP:IPR033926
+xref: MEDSCAN:urn:agi-aopfc:0000156
+xref: MEDSCAN:urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa
+xref: NCIT:C17380
+xref: SIGNOR:SIGNOR-PF12
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000312 ! NFkappaB_1
+relationship: has_part FPLX:000313 ! NFkappaB_2
+
+[Term]
+id: FPLX:000312
+name: NFkappaB-1
+synonym: "Class 1 NF-kappaBs" EXACT []
+synonym: "class 1 NF-kappaBs" EXACT []
+synonym: "Class 1 NF-κBs" EXACT []
+synonym: "class 1 NF-κBs" EXACT []
+synonym: "Class I NF-kappaBs" EXACT []
+synonym: "class I NF-kappaBs" EXACT []
+synonym: "Class I NF-κBs" EXACT []
+synonym: "class I NF-κBs" EXACT []
+synonym: "NF-kappaB Class 1" EXACT []
+synonym: "NF-kappaB class 1" EXACT []
+synonym: "NF-kappaB Class I" EXACT []
+synonym: "NF-kappaB class I" EXACT []
+synonym: "NF-κB Class 1" EXACT []
+synonym: "NF-κB class 1" EXACT []
+synonym: "NF-κB Class I" EXACT []
+synonym: "NF-κB class I" EXACT []
+xref: RE:R-HSA-177656
+xref: RE:R-HSA-177662
+relationship: part_of FPLX:000311 ! NFkappaB
+relationship: inverse_is_a HGNC:7794 ! NFKB1
+relationship: inverse_is_a HGNC:7795 ! NFKB2
+
+[Term]
+id: FPLX:000313
+name: NFkappaB-2
+synonym: "Class 2 NF-kappaBs" EXACT []
+synonym: "class 2 NF-kappaBs" EXACT []
+synonym: "Class 2 NF-κBs" EXACT []
+synonym: "class 2 NF-κBs" EXACT []
+synonym: "Class II NF-kappaBs" EXACT []
+synonym: "class II NF-kappaBs" EXACT []
+synonym: "Class II NF-κBs" EXACT []
+synonym: "class II NF-κBs" EXACT []
+synonym: "NF-kappaB Class 2" EXACT []
+synonym: "NF-kappaB class 2" EXACT []
+synonym: "NF-kappaB Class II" EXACT []
+synonym: "NF-kappaB class II" EXACT []
+synonym: "NF-κB Class 2" EXACT []
+synonym: "NF-κB class 2" EXACT []
+synonym: "NF-κB Class II" EXACT []
+synonym: "NF-κB class II" EXACT []
+relationship: part_of FPLX:000311 ! NFkappaB
+relationship: inverse_is_a HGNC:9955 ! RELA
+relationship: inverse_is_a HGNC:9956 ! RELB
+relationship: inverse_is_a HGNC:9954 ! REL
+
+[Term]
+id: FPLX:000314
+name: NFY
+synonym: "NF-Y" EXACT []
+synonym: "NFY" EXACT []
+synonym: "nuclear factor Y" EXACT []
+synonym: "nuclear factor-Y" EXACT []
+xref: BEL:"Nfy Complex"
+xref: RE:R-HSA-2426131
+xref: RE:R-HSA-381204
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:7804 ! NFYA
+relationship: has_part HGNC:7805 ! NFYB
+relationship: has_part HGNC:7806 ! NFYC
+
+[Term]
+id: FPLX:000315
+name: NKD
+synonym: "naked cuticle" EXACT []
+xref: BEL:"NKD Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:17045 ! NKD1
+relationship: inverse_is_a HGNC:17046 ! NKD2
+
+[Term]
+id: FPLX:000316
+name: NOS
+synonym: "NOS" EXACT []
+xref: BEL:"NOS Family"
+xref: IP:IPR004030
+xref: IP:IPR012144
+xref: MEDSCAN:urn:agi-aopfc:0000494
+xref: NEXTPROT-FAMILY:02504
+xref: RE:R-HSA-419294
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7872 ! NOS1
+relationship: inverse_is_a HGNC:7873 ! NOS2
+relationship: inverse_is_a HGNC:7876 ! NOS3
+
+[Term]
+id: FPLX:000317
+name: Notch
+synonym: "Notch" EXACT []
+xref: BEL:"NOTCH Family"
+xref: IP:IPR008297
+xref: IP:IPR010660
+xref: IP:IPR011656
+xref: MEDSCAN:urn:agi-aopfc:0000279
+xref: NEXTPROT-FAMILY:02506
+xref: XFAM:PF00066
+xref: RE:R-HSA-1911440
+xref: RE:R-HSA-1911472
+xref: RE:R-HSA-1911474
+xref: RE:R-HSA-1911547
+xref: RE:R-HSA-1911550
+xref: RE:R-HSA-212420
+xref: SIGNOR:SIGNOR-PF30
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:7881 ! NOTCH1
+relationship: inverse_is_a HGNC:7882 ! NOTCH2
+relationship: inverse_is_a HGNC:7883 ! NOTCH3
+relationship: inverse_is_a HGNC:7884 ! NOTCH4
+
+[Term]
+id: FPLX:000318
+name: NRG
+synonym: "neuregulin family" EXACT []
+synonym: "Neuregulin" EXACT []
+synonym: "neuregulin" EXACT []
+synonym: "Neuregulins" EXACT []
+synonym: "neuregulins" EXACT []
+synonym: "NRGs" EXACT []
+xref: MEDSCAN:urn:agi-protfc:neuregulin%20family
+xref: XFAM:PF02158
+xref: RE:R-HSA-1227957
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000319 ! NRG_1_2
+relationship: inverse_is_a FPLX:000320 ! NRG_3_4
+
+[Term]
+id: FPLX:000319
+name: NRG-1-2
+synonym: "NRG1-NRG2" EXACT []
+synonym: "NRG1/2" EXACT []
+xref: BEL:"NRG1/2 Family"
+xref: RE:R-HSA-1227956
+xref: RE:R-HSA-1247495
+xref: RE:R-HSA-1248743
+is_a: FPLX:000318 ! NRG
+relationship: inverse_is_a HGNC:7997 ! NRG1
+relationship: inverse_is_a HGNC:7998 ! NRG2
+
+[Term]
+id: FPLX:000320
+name: NRG-3-4
+synonym: "NRG3-NRG4" EXACT []
+synonym: "NRG3/4" EXACT []
+xref: BEL:"NRG3/4 Family"
+is_a: FPLX:000318 ! NRG
+relationship: inverse_is_a HGNC:7999 ! NRG3
+relationship: inverse_is_a HGNC:29862 ! NRG4
+
+[Term]
+id: FPLX:000321
+name: NTRK
+synonym: "NTRK" EXACT []
+synonym: "NTRKs" EXACT []
+synonym: "Trk receptor" EXACT []
+synonym: "trk receptor" EXACT []
+synonym: "Trk receptors" EXACT []
+synonym: "trk receptors" EXACT []
+xref: BEL:"NTRK Family"
+xref: IP:IPR020777
+xref: IP:IPR031635
+xref: MEDSCAN:urn:agi-aopfc:0000278
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8031 ! NTRK1
+relationship: inverse_is_a HGNC:8032 ! NTRK2
+relationship: inverse_is_a HGNC:8033 ! NTRK3
+
+[Term]
+id: FPLX:000322
+name: OGT-family
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:28526 ! EOGT
+relationship: inverse_is_a HGNC:8127 ! OGT
+relationship: inverse_is_a HGNC:19139 ! POMGNT1
+relationship: inverse_is_a HGNC:25902 ! POMGNT2
+
+[Term]
+id: FPLX:000323
+name: p14-3-3
+synonym: "14-3-3 proteins" EXACT []
+synonym: "14-3-3" EXACT []
+xref: BEL:"14-3-3 Family"
+xref: IP:IPR000308
+xref: IP:IPR023409
+xref: IP:IPR023410
+xref: MEDSCAN:urn:agi-protfc:14-3-3
+xref: XFAM:PF00244
+xref: RE:R-HSA-1445138
+xref: RE:R-HSA-2457842
+xref: SIGNOR:SIGNOR-PF7
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10773 ! SFN
+relationship: inverse_is_a HGNC:12849 ! YWHAB
+relationship: inverse_is_a HGNC:12851 ! YWHAE
+relationship: inverse_is_a HGNC:12852 ! YWHAG
+relationship: inverse_is_a HGNC:12853 ! YWHAH
+relationship: inverse_is_a HGNC:12854 ! YWHAQ
+relationship: inverse_is_a HGNC:12855 ! YWHAZ
+
+[Term]
+id: FPLX:000324
+name: P2RX
+synonym: "P2X purinoreceptor" EXACT []
+synonym: "P2X purinoreceptors" EXACT []
+synonym: "P2X receptor" EXACT []
+synonym: "P2X receptors" EXACT []
+synonym: "P2X" EXACT []
+xref: BEL:"P2RX Family"
+xref: GO:0004931
+xref: IP:IPR001429
+xref: IP:IPR027309
+xref: NEXTPROT-FAMILY:02630
+xref: XFAM:PF00864
+xref: RE:R-HSA-139848
+xref: RE:R-HSA-8861873
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8533 ! P2RX1
+relationship: inverse_is_a HGNC:15459 ! P2RX2
+relationship: inverse_is_a HGNC:8534 ! P2RX3
+relationship: inverse_is_a HGNC:8535 ! P2RX4
+relationship: inverse_is_a HGNC:8536 ! P2RX5
+relationship: inverse_is_a HGNC:8538 ! P2RX6
+relationship: inverse_is_a HGNC:8537 ! P2RX7
+
+[Term]
+id: FPLX:000325
+name: P2RY
+synonym: "P2Y receptor" EXACT []
+xref: BEL:"P2RY Family"
+xref: MEDSCAN:urn:agi-protfc:p2y%20receptor
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8539 ! P2RY1
+relationship: inverse_is_a HGNC:8541 ! P2RY2
+relationship: inverse_is_a HGNC:8542 ! P2RY4
+relationship: inverse_is_a HGNC:8543 ! P2RY6
+relationship: inverse_is_a HGNC:15524 ! P2RY8
+relationship: inverse_is_a HGNC:19906 ! P2RY10
+relationship: inverse_is_a HGNC:8540 ! P2RY11
+relationship: inverse_is_a HGNC:18124 ! P2RY12
+relationship: inverse_is_a HGNC:4537 ! P2RY13
+relationship: inverse_is_a HGNC:16442 ! P2RY14
+relationship: inverse_is_a HGNC:4478 ! LPAR4
+relationship: inverse_is_a HGNC:15520 ! LPAR6
+
+[Term]
+id: FPLX:000326
+name: p38
+synonym: "MAPK p38" EXACT []
+synonym: "P38 MAPK" EXACT []
+synonym: "p38 MAPK" EXACT []
+synonym: "p38 MAPKs" EXACT []
+synonym: "p38" EXACT []
+synonym: "p38-MAPK" EXACT []
+synonym: "p38MAPK" EXACT []
+xref: BEL:"MAPK p38 Family"
+xref: IP:IPR008352
+xref: MEDSCAN:urn:agi-aopfc:0000477
+xref: RE:R-HSA-1250100
+xref: RE:R-HSA-1250102
+xref: RE:R-HSA-171016
+xref: RE:R-HSA-189828
+xref: SIGNOR:SIGNOR-PF16
+is_a: FPLX:000283 ! MAPK
+relationship: inverse_is_a HGNC:6873 ! MAPK11
+relationship: inverse_is_a HGNC:6874 ! MAPK12
+relationship: inverse_is_a HGNC:6875 ! MAPK13
+relationship: inverse_is_a HGNC:6876 ! MAPK14
+
+[Term]
+id: FPLX:000327
+name: p53-family
+synonym: "P53 family" EXACT []
+synonym: "p53 Family" EXACT []
+synonym: "p53 family" EXACT []
+synonym: "p53/p63/p73 family" EXACT []
+xref: IP:IPR002117
+xref: IP:IPR010991
+xref: IP:IPR011615
+xref: NEXTPROT-FAMILY:02632
+xref: XFAM:PF00870
+xref: RE:R-HSA-6798076
+xref: RE:R-HSA-6798078
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11998 ! TP53
+relationship: inverse_is_a HGNC:15979 ! TP63
+relationship: inverse_is_a HGNC:12003 ! TP73
+
+[Term]
+id: FPLX:000328
+name: P70S6K
+synonym: "p70 S6 kinase" EXACT []
+synonym: "P70RSK" EXACT []
+synonym: "p70RSK" EXACT []
+synonym: "P70S6K" EXACT []
+synonym: "S6K" EXACT []
+xref: BEL:"RPS6KB Family"
+xref: MEDSCAN:urn:agi-protfc:p70rsk
+is_a: FPLX:000422 ! RSK
+relationship: inverse_is_a HGNC:10436 ! RPS6KB1
+relationship: inverse_is_a HGNC:10437 ! RPS6KB2
+
+[Term]
+id: FPLX:000329
+name: P90RSK
+synonym: "p90RSK" EXACT []
+synonym: "RPS6KA" EXACT []
+xref: BEL:"RPS6KA Family"
+xref: IP:IPR016239
+xref: MEDSCAN:urn:agi-protfc:p90rsk
+xref: RE:R-HSA-446849
+xref: SIGNOR:SIGNOR-PF26
+is_a: FPLX:000422 ! RSK
+relationship: inverse_is_a HGNC:10430 ! RPS6KA1
+relationship: inverse_is_a HGNC:10431 ! RPS6KA2
+relationship: inverse_is_a HGNC:10432 ! RPS6KA3
+relationship: inverse_is_a HGNC:10433 ! RPS6KA4
+relationship: inverse_is_a HGNC:10434 ! RPS6KA5
+relationship: inverse_is_a HGNC:10435 ! RPS6KA6
+
+[Term]
+id: FPLX:000330
+name: PAK
+synonym: "PAK" EXACT []
+synonym: "Pak" EXACT []
+xref: BEL:"PAK Family"
+xref: IP:IPR033923
+xref: MEDSCAN:urn:agi-aopfc:0000468
+xref: RE:R-HSA-428475
+xref: SIGNOR:SIGNOR-PF13
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8590 ! PAK1
+relationship: inverse_is_a HGNC:8591 ! PAK2
+relationship: inverse_is_a HGNC:8592 ! PAK3
+relationship: inverse_is_a HGNC:16059 ! PAK4
+relationship: inverse_is_a HGNC:15916 ! PAK5
+relationship: inverse_is_a HGNC:16061 ! PAK6
+
+[Term]
+id: FPLX:000331
+name: PARP
+synonym: "PARP genes" EXACT []
+synonym: "PARPs" EXACT []
+synonym: "Poly(ADP-ribose) polymerase" EXACT []
+synonym: "Poly(ADP-ribose) polymerases" EXACT []
+xref: XFAM:PF00644
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:270 ! PARP1
+relationship: inverse_is_a HGNC:272 ! PARP2
+relationship: inverse_is_a HGNC:273 ! PARP3
+relationship: inverse_is_a HGNC:271 ! PARP4
+relationship: inverse_is_a HGNC:26921 ! PARP6
+relationship: inverse_is_a HGNC:26124 ! PARP8
+relationship: inverse_is_a HGNC:24118 ! PARP9
+relationship: inverse_is_a HGNC:25895 ! PARP10
+relationship: inverse_is_a HGNC:1186 ! PARP11
+relationship: inverse_is_a HGNC:21919 ! PARP12
+relationship: inverse_is_a HGNC:29232 ! PARP14
+relationship: inverse_is_a HGNC:26876 ! PARP15
+relationship: inverse_is_a HGNC:26040 ! PARP16
+relationship: inverse_is_a HGNC:11941 ! TNKS
+relationship: inverse_is_a HGNC:15677 ! TNKS2
+relationship: inverse_is_a HGNC:23696 ! TIPARP
+
+[Term]
+id: FPLX:000332
+name: PARV
+synonym: "Parvin" EXACT []
+synonym: "parvin" EXACT []
+synonym: "Parvins" EXACT []
+synonym: "parvins" EXACT []
+xref: BEL:"PARV Family"
+xref: IP:IPR028433
+xref: NEXTPROT-FAMILY:02660
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:14652 ! PARVA
+relationship: inverse_is_a HGNC:14653 ! PARVB
+relationship: inverse_is_a HGNC:14654 ! PARVG
+
+[Term]
+id: FPLX:000333
+name: Patched
+synonym: "PATCHED" EXACT []
+synonym: "Patched" EXACT []
+xref: IP:IPR004766
+xref: MEDSCAN:urn:agi-aopfc:0000281
+xref: XFAM:PF02460
+xref: RE:R-HSA-445134
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9585 ! PTCH1
+relationship: inverse_is_a HGNC:9586 ! PTCH2
+
+[Term]
+id: FPLX:000334
+name: PBX
+synonym: "PBX" EXACT []
+synonym: "Pbx" EXACT []
+synonym: "pbx" EXACT []
+synonym: "PBXs" EXACT []
+xref: BEL:"PBX Family"
+xref: IP:IPR005542
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8632 ! PBX1
+relationship: inverse_is_a HGNC:8633 ! PBX2
+relationship: inverse_is_a HGNC:8634 ! PBX3
+relationship: inverse_is_a HGNC:13403 ! PBX4
+
+[Term]
+id: FPLX:000335
+name: PDE
+synonym: "PDE" EXACT []
+synonym: "PDEs" EXACT []
+synonym: "Phosphodiesterase" EXACT []
+synonym: "phosphodiesterase" EXACT []
+synonym: "Phosphodiesterases" EXACT []
+synonym: "phosphodiesterases" EXACT []
+xref: BEL:"PDE Family"
+xref: ECCODE:3.1.4.-
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8777 ! PDE2A
+relationship: inverse_is_a HGNC:8795 ! PDE9A
+relationship: inverse_is_a HGNC:8772 ! PDE10A
+relationship: inverse_is_a HGNC:8773 ! PDE11A
+relationship: inverse_is_a FPLX:000336 ! PDE1
+relationship: inverse_is_a FPLX:000337 ! PDE3
+relationship: inverse_is_a FPLX:000338 ! PDE4
+relationship: inverse_is_a FPLX:000339 ! PDE6
+relationship: inverse_is_a FPLX:000340 ! PDE7
+relationship: inverse_is_a FPLX:000341 ! PDE8
+
+[Term]
+id: FPLX:000336
+name: PDE1
+synonym: "PDE1 family" EXACT []
+synonym: "PDE1" EXACT []
+synonym: "Phosphodiesterase 1" EXACT []
+synonym: "phosphodiesterase 1" EXACT []
+synonym: "Phosphodiesterase-1" EXACT []
+synonym: "phosphodiesterase-1" EXACT []
+xref: BEL:"PDE1 Family"
+xref: GO:0004117
+xref: IP:IPR013706
+xref: RE:R-HSA-111952
+xref: RE:R-HSA-111953
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8774 ! PDE1A
+relationship: inverse_is_a HGNC:8775 ! PDE1B
+relationship: inverse_is_a HGNC:8776 ! PDE1C
+
+[Term]
+id: FPLX:000337
+name: PDE3
+synonym: "PDE 3" EXACT []
+synonym: "PDE3 family" EXACT []
+synonym: "PDE3" EXACT []
+synonym: "Phosphodiesterase 3" EXACT []
+synonym: "phosphodiesterase 3" EXACT []
+synonym: "Phosphodiesterase-3" EXACT []
+synonym: "phosphodiesterase-3" EXACT []
+xref: BEL:"PDE3 Family"
+xref: MEDSCAN:urn:agi-protfc:phosphodiesterase%20III
+xref: NEXTPROT-FAMILY:00803
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8778 ! PDE3A
+relationship: inverse_is_a HGNC:8779 ! PDE3B
+
+[Term]
+id: FPLX:000338
+name: PDE4
+synonym: "PDE4 family" EXACT []
+synonym: "PDE4 isoforms" EXACT []
+synonym: "PDE4" EXACT []
+synonym: "Phosphodiesterase 4" EXACT []
+synonym: "phosphodiesterase 4" EXACT []
+synonym: "Phosphodiesterase-4" EXACT []
+synonym: "phosphodiesterase-4" EXACT []
+synonym: "type 4 cyclic nucleotide phosphodiesterase" EXACT []
+xref: BEL:"PDE4 Family"
+xref: MEDSCAN:urn:agi-protfc:PDE4%20subfamily
+xref: NCIT:C107433
+xref: NEXTPROT-FAMILY:00804
+xref: RE:R-HSA-111960
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8780 ! PDE4A
+relationship: inverse_is_a HGNC:8781 ! PDE4B
+relationship: inverse_is_a HGNC:8782 ! PDE4C
+relationship: inverse_is_a HGNC:8783 ! PDE4D
+
+[Term]
+id: FPLX:000339
+name: PDE6
+synonym: "PDE6 family" EXACT []
+synonym: "PDE6" EXACT []
+synonym: "Phosphodiesterase 6" EXACT []
+synonym: "phosphodiesterase 6" EXACT []
+synonym: "Phosphodiesterase-6" EXACT []
+synonym: "phosphodiesterase-6" EXACT []
+xref: BEL:"PDE6 Family"
+xref: MEDSCAN:urn:agi-aopfc:0000704
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8785 ! PDE6A
+relationship: inverse_is_a HGNC:8786 ! PDE6B
+relationship: inverse_is_a HGNC:8787 ! PDE6C
+
+[Term]
+id: FPLX:000340
+name: PDE7
+synonym: "PDE7" EXACT []
+synonym: "Phosphodiesterase 7" EXACT []
+synonym: "phosphodiesterase 7" EXACT []
+synonym: "Phosphodiesterase-7" EXACT []
+synonym: "phosphodiesterase-7" EXACT []
+xref: RE:R-HSA-418540
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8791 ! PDE7A
+relationship: inverse_is_a HGNC:8792 ! PDE7B
+
+[Term]
+id: FPLX:000341
+name: PDE8
+synonym: "PDE8" EXACT []
+synonym: "Phosphodiesterase 8" EXACT []
+synonym: "phosphodiesterase 8" EXACT []
+synonym: "Phosphodiesterase-8" EXACT []
+synonym: "phosphodiesterase-8" EXACT []
+xref: RE:R-HSA-418541
+is_a: FPLX:000335 ! PDE
+relationship: inverse_is_a HGNC:8793 ! PDE8A
+relationship: inverse_is_a HGNC:8794 ! PDE8B
+
+[Term]
+id: FPLX:000342
+name: PDGF
+synonym: "PDGF" EXACT []
+xref: BEL:"PDGF Family"
+xref: GO:0005161
+xref: NCIT:C20448
+xref: RE:R-HSA-381926
+xref: RE:R-HSA-381936
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8799 ! PDGFA
+relationship: inverse_is_a HGNC:8800 ! PDGFB
+relationship: inverse_is_a HGNC:8801 ! PDGFC
+relationship: inverse_is_a HGNC:30620 ! PDGFD
+
+[Term]
+id: FPLX:000343
+name: PDGFR
+synonym: "PDGFR" EXACT []
+xref: BEL:"PDGFR Family"
+xref: NCIT:C17322
+xref: RE:R-HSA-186769
+xref: RE:R-HSA-186770
+xref: RE:R-HSA-186791
+xref: RE:R-HSA-186792
+xref: RE:R-HSA-186821
+xref: RE:R-HSA-8864040
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8803 ! PDGFRA
+relationship: inverse_is_a HGNC:8804 ! PDGFRB
+
+[Term]
+id: FPLX:000344
+name: PDGFR-AA
+synonym: "PDGFR-AA" EXACT []
+synonym: "PDGFR-alphaalpha" EXACT []
+synonym: "PDGFR-αα" EXACT []
+synonym: "PDGFRalphaalpha" EXACT []
+synonym: "PDGFRαα" EXACT []
+xref: IP:IPR027290
+xref: RE:R-HSA-186816
+xref: RE:R-HSA-186817
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8803 ! PDGFRA
+
+[Term]
+id: FPLX:000345
+name: PDGFR-AB
+synonym: "PDGFR-AB" EXACT []
+synonym: "PDGFR-alphabeta" EXACT []
+synonym: "PDGFR-αβ" EXACT []
+synonym: "PDGFRalphabeta" EXACT []
+synonym: "PDGFRαβ" EXACT []
+xref: RE:R-HSA-186769
+xref: RE:R-HSA-186770
+xref: RE:R-HSA-186791
+xref: RE:R-HSA-186792
+xref: RE:R-HSA-186821
+xref: RE:R-HSA-8864040
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8803 ! PDGFRA
+relationship: has_part HGNC:8804 ! PDGFRB
+
+[Term]
+id: FPLX:000346
+name: PDGFR-BB
+synonym: "PDGFR-BB" EXACT []
+synonym: "PDGFR-betabeta" EXACT []
+synonym: "PDGFR-ββ" EXACT []
+synonym: "PDGFRbetabeta" EXACT []
+synonym: "PDGFRββ" EXACT []
+xref: IP:IPR027288
+xref: RE:R-HSA-186799
+xref: RE:R-HSA-186805
+xref: RE:R-HSA-8864046
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8804 ! PDGFRB
+
+[Term]
+id: FPLX:000347
+name: PDGF-AA
+synonym: "PDGF-AA" EXACT []
+synonym: "PDGF-aa" EXACT []
+synonym: "PDGFAA" EXACT []
+xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AA
+xref: RE:R-HSA-184203
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8799 ! PDGFA
+
+[Term]
+id: FPLX:000348
+name: PDGF-AB
+synonym: "PDGF-AB" EXACT []
+synonym: "PDGF-ab" EXACT []
+synonym: "PDGFAB" EXACT []
+xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AB
+xref: RE:R-HSA-380759
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8799 ! PDGFA
+relationship: has_part HGNC:8800 ! PDGFB
+
+[Term]
+id: FPLX:000349
+name: PDGF-BB
+synonym: "PDGF-BB" EXACT []
+synonym: "PDGF-bb" EXACT []
+synonym: "PDGFBB" EXACT []
+xref: IP:IPR015583
+xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20BB
+xref: MESH:C072194
+xref: RE:R-HSA-184196
+xref: RE:R-HSA-184198
+xref: RE:R-HSA-184204
+xref: RE:R-HSA-184206
+xref: RE:R-HSA-2426276
+xref: RE:R-HSA-380748
+xref: RE:R-HSA-380751
+xref: RE:R-HSA-380759
+xref: RE:R-HSA-381935
+xref: RE:R-HSA-381938
+xref: RE:R-HSA-387074
+xref: RE:R-HSA-392712
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8800 ! PDGFB
+
+[Term]
+id: FPLX:000350
+name: PDGF-CC
+synonym: "PDGF CC" EXACT []
+synonym: "PDGF-CC" EXACT []
+synonym: "PDGF-cc" EXACT []
+xref: RE:R-HSA-381941
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8801 ! PDGFC
+
+[Term]
+id: FPLX:000351
+name: PDGF-DD
+synonym: "PDGF DD" EXACT []
+synonym: "PDGF-DD" EXACT []
+synonym: "PDGF-dd" EXACT []
+xref: RE:R-HSA-381930
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:30620 ! PDGFD
+
+[Term]
+id: FPLX:000352
+name: PDH
+synonym: "PDH" EXACT []
+synonym: "pyruvate dehydrogenase (acetyl-transferring)" EXACT []
+xref: BEL:"Pyruvate Dehydrogenase Complex"
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2896 ! DLAT
+relationship: has_part HGNC:2898 ! DLD
+relationship: has_part HGNC:8806 ! PDHA1
+relationship: has_part HGNC:8807 ! PDHA2
+relationship: has_part HGNC:8808 ! PDHB
+relationship: has_part HGNC:21350 ! PDHX
+
+[Term]
+id: FPLX:000353
+name: PDK
+synonym: "PDK" EXACT []
+synonym: "PDKs" EXACT []
+synonym: "Pyruvate dehydrogenase kinase" EXACT []
+synonym: "pyruvate dehydrogenase kinase" EXACT []
+xref: BEL:"PDK Family"
+xref: ECCODE:1.2.4.1
+xref: RE:R-HSA-203947
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8809 ! PDK1
+relationship: inverse_is_a HGNC:8810 ! PDK2
+relationship: inverse_is_a HGNC:8811 ! PDK3
+relationship: inverse_is_a HGNC:8812 ! PDK4
+
+[Term]
+id: FPLX:000354
+name: Pertussis-toxin
+synonym: "Pertussis toxin" EXACT []
+synonym: "pertussis toxin" EXACT []
+synonym: "PTX" EXACT []
+xref: NCIT:C736
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000355
+name: PFN
+synonym: "Profilin" EXACT []
+synonym: "profilin" EXACT []
+synonym: "Profilins" EXACT []
+synonym: "profilins" EXACT []
+xref: BEL:"PFN Family"
+xref: IP:IPR005455
+xref: MEDSCAN:urn:agi-protfc:profilin
+xref: XFAM:PF00235
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8881 ! PFN1
+relationship: inverse_is_a HGNC:8882 ! PFN2
+relationship: inverse_is_a HGNC:18627 ! PFN3
+relationship: inverse_is_a HGNC:31103 ! PFN4
+
+[Term]
+id: FPLX:000356
+name: PhK
+synonym: "PhK" EXACT []
+synonym: "Phosphorylase kinase" EXACT []
+synonym: "phosphorylase kinase" EXACT []
+xref: BEL:"Phosphorylase B Kinase Complex"
+xref: ECCODE:2.7.11.19
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1442 ! CALM1
+relationship: has_part HGNC:8925 ! PHKA1
+relationship: has_part HGNC:8926 ! PHKA2
+relationship: has_part HGNC:8927 ! PHKB
+relationship: has_part HGNC:8930 ! PHKG1
+relationship: has_part HGNC:8931 ! PHKG2
+
+[Term]
+id: FPLX:000357
+name: Phosphatase
+synonym: "phosphatase" EXACT []
+xref: MESH:D010749
+xref: NCIT:C16981
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000358
+name: PI3K
+synonym: "phosphatidylinositol 3-kinase" EXACT []
+synonym: "PI 3-kinase" EXACT []
+synonym: "PI 3-kinases" EXACT []
+synonym: "PI3-kinase" EXACT []
+synonym: "PI3K" EXACT []
+synonym: "PI3Kinase" EXACT []
+xref: BEL:"p85/p110 PI3Kinase Complex"
+xref: MEDSCAN:urn:agi-aopfc:0000447
+xref: MEDSCAN:urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa
+xref: NCIT:C17270
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000359 ! PI3K_p110
+relationship: has_part FPLX:000361 ! PIK3R_I
+
+[Term]
+id: FPLX:000359
+name: PI3K-p110
+synonym: "p110" EXACT []
+synonym: "PI3K p110 subunit" EXACT []
+synonym: "PIK3C" EXACT []
+xref: BEL:"PIK3C Class IA Family"
+xref: IP:IPR003113
+relationship: part_of FPLX:000358 ! PI3K
+relationship: inverse_is_a HGNC:8975 ! PIK3CA
+relationship: inverse_is_a HGNC:8976 ! PIK3CB
+relationship: inverse_is_a HGNC:8977 ! PIK3CD
+relationship: inverse_is_a HGNC:8978 ! PIK3CG
+
+[Term]
+id: FPLX:000360
+name: PI3K-p85
+synonym: "p85" EXACT []
+xref: RE:R-HSA-74688
+is_a: FPLX:000361 ! PIK3R_I
+relationship: inverse_is_a HGNC:8979 ! PIK3R1
+relationship: inverse_is_a HGNC:8980 ! PIK3R2
+
+[Term]
+id: FPLX:000361
+name: PIK3R-I
+synonym: "PIK3R" EXACT []
+xref: BEL:"PIK3R Class IA Family"
+relationship: part_of FPLX:000358 ! PI3K
+relationship: inverse_is_a HGNC:8981 ! PIK3R3
+relationship: inverse_is_a HGNC:8982 ! PIK3R4
+relationship: inverse_is_a HGNC:30035 ! PIK3R5
+relationship: inverse_is_a HGNC:27101 ! PIK3R6
+relationship: inverse_is_a FPLX:000360 ! PI3K_p85
+
+[Term]
+id: FPLX:000362
+name: PIM
+synonym: "PIM" EXACT []
+xref: IP:IPR017348
+xref: NEXTPROT-FAMILY:03078
+xref: SIGNOR:SIGNOR-PF34
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8986 ! PIM1
+relationship: inverse_is_a HGNC:8987 ! PIM2
+relationship: inverse_is_a HGNC:19310 ! PIM3
+
+[Term]
+id: FPLX:000363
+name: PKA
+synonym: "cAMP-dependent PK" EXACT []
+synonym: "cAMP-dependent protein kinase" EXACT []
+synonym: "cyclic AMP-dependent protein kinase" EXACT []
+synonym: "cyclic-AMP-dependent protein kinase" EXACT []
+synonym: "PK-A" EXACT []
+synonym: "PKA" EXACT []
+synonym: "protein kinase A" EXACT []
+xref: ECCODE:2.7.11.11
+xref: NCIT:C16479
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000390 ! PRKAR
+relationship: has_part FPLX:000389 ! PRKAC
+
+[Term]
+id: FPLX:000364
+name: PKC
+synonym: "PKC" EXACT []
+synonym: "protein kinase C" EXACT []
+xref: BEL:"PRKC Family"
+xref: ECCODE:2.7.11.13
+xref: IP:IPR012233
+xref: MESH:D011493
+xref: NCIT:C17017
+xref: NEXTPROT-FAMILY:03065
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9393 ! PRKCA
+relationship: inverse_is_a HGNC:9395 ! PRKCB
+relationship: inverse_is_a HGNC:9399 ! PRKCD
+relationship: inverse_is_a HGNC:9401 ! PRKCE
+relationship: inverse_is_a HGNC:9402 ! PRKCG
+relationship: inverse_is_a HGNC:9403 ! PRKCH
+relationship: inverse_is_a HGNC:9404 ! PRKCI
+relationship: inverse_is_a HGNC:9410 ! PRKCQ
+relationship: inverse_is_a HGNC:9412 ! PRKCZ
+relationship: inverse_is_a HGNC:9408 ! PRKD3
+
+[Term]
+id: FPLX:000365
+name: PKI
+synonym: "PKI" EXACT []
+xref: BEL:"PKI Family"
+xref: IP:IPR004171
+xref: XFAM:PF02827
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9017 ! PKIA
+relationship: inverse_is_a HGNC:9018 ! PKIB
+relationship: inverse_is_a HGNC:9019 ! PKIG
+
+[Term]
+id: FPLX:000366
+name: PLA2
+synonym: "cPLA2" EXACT []
+synonym: "cytosolic phospholipase A(2)" EXACT []
+synonym: "cytosolic phospholipase A2" EXACT []
+synonym: "cytosolic PLA2" EXACT []
+synonym: "phospholipase A2" EXACT []
+xref: BEL:"PLA2 Family"
+xref: ECCODE:3.1.1.4
+xref: MEDSCAN:urn:agi-aopfc:0000455
+xref: MEDSCAN:urn:agi-protfc:cytosolic%20phospholipase%20a2
+xref: NCIT:C16979
+xref: NEXTPROT-FAMILY:02840
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9030 ! PLA2G1B
+relationship: inverse_is_a HGNC:17934 ! PLA2G3
+relationship: inverse_is_a HGNC:9038 ! PLA2G5
+relationship: inverse_is_a HGNC:9039 ! PLA2G6
+relationship: inverse_is_a HGNC:9040 ! PLA2G7
+relationship: inverse_is_a HGNC:9029 ! PLA2G10
+relationship: inverse_is_a HGNC:18554 ! PLA2G12A
+relationship: inverse_is_a HGNC:18555 ! PLA2G12B
+relationship: inverse_is_a FPLX:000367 ! PLA2G2
+relationship: inverse_is_a FPLX:000368 ! PLA2G4
+
+[Term]
+id: FPLX:000367
+name: PLA2G2
+synonym: "GII PLA2" EXACT []
+synonym: "GIIPLA2" EXACT []
+synonym: "phospholipase A2 group-II" EXACT []
+synonym: "PLA2G2" EXACT []
+synonym: "PLA2g2" EXACT []
+xref: BEL:"PLA2G2 Family"
+is_a: FPLX:000366 ! PLA2
+relationship: inverse_is_a HGNC:9031 ! PLA2G2A
+relationship: inverse_is_a HGNC:9032 ! PLA2G2C
+relationship: inverse_is_a HGNC:9033 ! PLA2G2D
+relationship: inverse_is_a HGNC:13414 ! PLA2G2E
+relationship: inverse_is_a HGNC:30040 ! PLA2G2F
+
+[Term]
+id: FPLX:000368
+name: PLA2G4
+synonym: "gIV-PLA(2)" EXACT []
+synonym: "group IV-PLA(2)" EXACT []
+synonym: "Phospholipase A2 Group IV" EXACT []
+synonym: "phospholipase A2 group-IV" EXACT []
+synonym: "PLA2G4" EXACT []
+xref: NCIT:C19836
+is_a: FPLX:000366 ! PLA2
+relationship: inverse_is_a HGNC:9035 ! PLA2G4A
+relationship: inverse_is_a HGNC:9037 ! PLA2G4C
+relationship: inverse_is_a HGNC:30038 ! PLA2G4D
+
+[Term]
+id: FPLX:000369
+name: PLC
+synonym: "Phospholipase C" EXACT []
+synonym: "phospholipase C" EXACT []
+synonym: "Phospholipase-C" EXACT []
+synonym: "phospholipase-C" EXACT []
+synonym: "PLC" EXACT []
+xref: BEL:"PLC Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:17175 ! PLCE1
+relationship: inverse_is_a HGNC:19218 ! PLCZ1
+relationship: inverse_is_a FPLX:000370 ! PLCB
+relationship: inverse_is_a FPLX:000371 ! PLCD
+relationship: inverse_is_a FPLX:000372 ! PLCG
+
+[Term]
+id: FPLX:000370
+name: PLCB
+synonym: "Phospholipase C-beta" EXACT []
+synonym: "phospholipase C-beta" EXACT []
+synonym: "Phospholipase C-β" EXACT []
+synonym: "phospholipase C-β" EXACT []
+synonym: "Phospholipase Cbeta" EXACT []
+synonym: "phospholipase Cbeta" EXACT []
+synonym: "Phospholipase Cβ" EXACT []
+synonym: "phospholipase Cβ" EXACT []
+xref: BEL:"PLCB Family"
+xref: IP:IPR016280
+xref: RE:R-HSA-111854
+is_a: FPLX:000369 ! PLC
+relationship: inverse_is_a HGNC:15917 ! PLCB1
+relationship: inverse_is_a HGNC:9055 ! PLCB2
+relationship: inverse_is_a HGNC:9056 ! PLCB3
+relationship: inverse_is_a HGNC:9059 ! PLCB4
+
+[Term]
+id: FPLX:000371
+name: PLCD
+synonym: "Phospholipase C-delta" EXACT []
+synonym: "phospholipase C-delta" EXACT []
+synonym: "Phospholipase C-δ" EXACT []
+synonym: "phospholipase C-δ" EXACT []
+synonym: "Phospholipase Cdelta" EXACT []
+synonym: "phospholipase Cdelta" EXACT []
+synonym: "Phospholipase Cδ" EXACT []
+synonym: "phospholipase Cδ" EXACT []
+is_a: FPLX:000369 ! PLC
+relationship: inverse_is_a HGNC:9060 ! PLCD1
+relationship: inverse_is_a HGNC:9061 ! PLCD3
+relationship: inverse_is_a HGNC:9062 ! PLCD4
+
+[Term]
+id: FPLX:000372
+name: PLCG
+synonym: "PLC-gamma" EXACT []
+synonym: "PLC-γ" EXACT []
+xref: BEL:"PLCG Family"
+xref: IP:IPR016279
+xref: IP:IPR035023
+xref: IP:IPR035024
+xref: NCIT:C126114
+xref: RE:R-HSA-1168365
+xref: RE:R-HSA-1169086
+xref: RE:R-HSA-1169089
+xref: RE:R-HSA-2029095
+xref: RE:R-HSA-2685653
+is_a: FPLX:000369 ! PLC
+relationship: inverse_is_a HGNC:9065 ! PLCG1
+relationship: inverse_is_a HGNC:9066 ! PLCG2
+
+[Term]
+id: FPLX:000373
+name: PLD
+synonym: "Phospholipase D" EXACT []
+synonym: "phospholipase D" EXACT []
+xref: BEL:"PLD Family"
+xref: ECCODE:3.1.4.4
+xref: IP:IPR015679
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9067 ! PLD1
+relationship: inverse_is_a HGNC:9068 ! PLD2
+relationship: inverse_is_a HGNC:17158 ! PLD3
+relationship: inverse_is_a HGNC:23792 ! PLD4
+relationship: inverse_is_a HGNC:26879 ! PLD5
+relationship: inverse_is_a HGNC:30447 ! PLD6
+
+[Term]
+id: FPLX:000374
+name: PPAP2
+synonym: "type 2 phosphatidic acid phosphatase" EXACT []
+synonym: "type 2 phosphatidic acid phosphatases" EXACT []
+synonym: "type II phosphatidic acid phosphatase" EXACT []
+synonym: "type II phosphatidic acid phosphatases" EXACT []
+xref: BEL:"PPAP2 Family"
+xref: RE:R-HSA-428110
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9228 ! PLPP1
+relationship: inverse_is_a HGNC:9230 ! PLPP2
+relationship: inverse_is_a HGNC:9229 ! PLPP3
+
+[Term]
+id: FPLX:000375
+name: PPAR
+synonym: "PPAR" EXACT []
+xref: BEL:"PPAR Family"
+xref: IP:IPR003074
+xref: MEDSCAN:urn:agi-protfc:ppar
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9232 ! PPARA
+relationship: inverse_is_a HGNC:9235 ! PPARD
+relationship: inverse_is_a HGNC:9236 ! PPARG
+
+[Term]
+id: FPLX:000376
+name: PPP1
+synonym: "PP1 regulator" EXACT []
+synonym: "PP1" EXACT []
+synonym: "PPP1" EXACT []
+xref: GO:0008599
+xref: MEDSCAN:urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c
+xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%201%20complex
+xref: NEXTPROT-FAMILY:03001
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000377 ! PPP1C
+relationship: has_part FPLX:000378 ! PPP1R
+
+[Term]
+id: FPLX:000377
+name: PPP1C
+synonym: "PP1C" EXACT []
+synonym: "PP1c" EXACT []
+synonym: "PPP1C" EXACT []
+xref: BEL:"PPP1C Family"
+xref: IP:IPR031675
+xref: RE:R-HSA-163538
+relationship: part_of FPLX:000376 ! PPP1
+relationship: inverse_is_a HGNC:9281 ! PPP1CA
+relationship: inverse_is_a HGNC:9282 ! PPP1CB
+relationship: inverse_is_a HGNC:9283 ! PPP1CC
+
+[Term]
+id: FPLX:000378
+name: PPP1R
+synonym: "PP1R" EXACT []
+synonym: "PP1r" EXACT []
+xref: BEL:"PPP1R Family"
+relationship: part_of FPLX:000376 ! PPP1
+relationship: inverse_is_a HGNC:9284 ! PPP1R10
+relationship: inverse_is_a HGNC:9285 ! PPP1R11
+relationship: inverse_is_a HGNC:7618 ! PPP1R12A
+relationship: inverse_is_a HGNC:7619 ! PPP1R12B
+relationship: inverse_is_a HGNC:14947 ! PPP1R12C
+relationship: inverse_is_a HGNC:14950 ! PPP1R13B
+relationship: inverse_is_a HGNC:14871 ! PPP1R14A
+relationship: inverse_is_a HGNC:9057 ! PPP1R14B
+relationship: inverse_is_a HGNC:14952 ! PPP1R14C
+relationship: inverse_is_a HGNC:14953 ! PPP1R14D
+relationship: inverse_is_a HGNC:14375 ! PPP1R15A
+relationship: inverse_is_a HGNC:14951 ! PPP1R15B
+relationship: inverse_is_a HGNC:14941 ! PPP1R16A
+relationship: inverse_is_a HGNC:15850 ! PPP1R16B
+relationship: inverse_is_a HGNC:9286 ! PPP1R1A
+relationship: inverse_is_a HGNC:9287 ! PPP1R1B
+relationship: inverse_is_a HGNC:14940 ! PPP1R1C
+relationship: inverse_is_a HGNC:9288 ! PPP1R2
+relationship: inverse_is_a HGNC:9291 ! PPP1R3A
+relationship: inverse_is_a HGNC:14942 ! PPP1R3B
+relationship: inverse_is_a HGNC:9293 ! PPP1R3C
+relationship: inverse_is_a HGNC:9294 ! PPP1R3D
+relationship: inverse_is_a HGNC:14944 ! PPP1R3F
+relationship: inverse_is_a HGNC:9295 ! PPP1R7
+relationship: inverse_is_a HGNC:9296 ! PPP1R8
+relationship: inverse_is_a HGNC:14946 ! PPP1R9A
+relationship: inverse_is_a HGNC:9298 ! PPP1R9B
+
+[Term]
+id: FPLX:000379
+name: PPP2
+synonym: "PP2 phosphatases" EXACT []
+synonym: "PP2" EXACT []
+synonym: "PP2A" EXACT []
+synonym: "protein phosphatase 2" EXACT []
+xref: MEDSCAN:urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3
+xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%202A%20complex
+xref: RE:R-HSA-196206
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000380 ! PPP2C
+relationship: has_part FPLX:000381 ! PPP2R_A
+relationship: has_part FPLX:000382 ! PPP2R_B
+
+[Term]
+id: FPLX:000380
+name: PPP2C
+synonym: "PP2A catalytic C subunit" EXACT []
+synonym: "PP2A-C" EXACT []
+synonym: "PP2Ac" EXACT []
+xref: BEL:"PPP2C Family"
+relationship: part_of FPLX:000379 ! PPP2
+relationship: inverse_is_a HGNC:20785 ! PPM1J
+relationship: inverse_is_a HGNC:9299 ! PPP2CA
+relationship: inverse_is_a HGNC:9300 ! PPP2CB
+
+[Term]
+id: FPLX:000381
+name: PPP2R-A
+synonym: "PP2A regulatory subunit A" EXACT []
+synonym: "regulatory A subunit of PP2A" EXACT []
+xref: BEL:"PPP2R Subunit A Family"
+xref: RE:R-HSA-165990
+xref: RE:R-HSA-165997
+relationship: part_of FPLX:000379 ! PPP2
+relationship: inverse_is_a HGNC:9302 ! PPP2R1A
+relationship: inverse_is_a HGNC:9303 ! PPP2R1B
+
+[Term]
+id: FPLX:000382
+name: PPP2R-B
+synonym: "PP2A regulatory subunit B" EXACT []
+synonym: "regulatory B subunit of PP2A" EXACT []
+xref: BEL:"PPP2R Subunit B Family"
+relationship: part_of FPLX:000379 ! PPP2
+relationship: inverse_is_a HGNC:9304 ! PPP2R2A
+relationship: inverse_is_a HGNC:9305 ! PPP2R2B
+relationship: inverse_is_a HGNC:9306 ! PPP2R2C
+relationship: inverse_is_a HGNC:23732 ! PPP2R2D
+relationship: inverse_is_a HGNC:9307 ! PPP2R3A
+relationship: inverse_is_a HGNC:13417 ! PPP2R3B
+relationship: inverse_is_a HGNC:9308 ! PTPA
+relationship: inverse_is_a HGNC:9309 ! PPP2R5A
+relationship: inverse_is_a HGNC:9310 ! PPP2R5B
+relationship: inverse_is_a HGNC:9311 ! PPP2R5C
+relationship: inverse_is_a HGNC:9312 ! PPP2R5D
+relationship: inverse_is_a HGNC:9313 ! PPP2R5E
+
+[Term]
+id: FPLX:000383
+name: PPP3
+synonym: "calcineurin" EXACT []
+synonym: "CaN" EXACT []
+synonym: "PP2B" EXACT []
+synonym: "protein phosphatase 2B" EXACT []
+xref: BEL:"Calcineurin Complex"
+xref: BEL:"PPP3 Family"
+xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%203
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000384 ! PPP3C
+relationship: has_part FPLX:000385 ! PPP3R
+
+[Term]
+id: FPLX:000384
+name: PPP3C
+synonym: "Calcineurin catalytic subunit" EXACT []
+synonym: "catalytic subunit of calcineurin" EXACT []
+synonym: "PP2B catalytic subunit" EXACT []
+xref: BEL:"PPP3C Family"
+xref: RE:R-HSA-201779
+xref: RE:R-HSA-201798
+xref: SIGNOR:SIGNOR-PF18
+relationship: part_of FPLX:000383 ! PPP3
+relationship: inverse_is_a HGNC:9314 ! PPP3CA
+relationship: inverse_is_a HGNC:9315 ! PPP3CB
+relationship: inverse_is_a HGNC:9316 ! PPP3CC
+
+[Term]
+id: FPLX:000385
+name: PPP3R
+synonym: "Calcineurin regulatory subunit" EXACT []
+synonym: "regulatory subunit of calcineurin" EXACT []
+xref: BEL:"PPP3R Family"
+xref: NEXTPROT-FAMILY:00421
+relationship: part_of FPLX:000383 ! PPP3
+relationship: inverse_is_a HGNC:9317 ! PPP3R1
+relationship: inverse_is_a HGNC:9318 ! PPP3R2
+
+[Term]
+id: FPLX:000386
+name: PRC1-complex
+synonym: "polycomb Repressive Complex (PRC) 1" EXACT []
+synonym: "Polycomb Repressive Complex 1" EXACT []
+synonym: "Polycomb repressive complex 1" EXACT []
+synonym: "polycomb repressive complex 1" EXACT []
+synonym: "Polycomb repressive complex PRC1" EXACT []
+synonym: "Polycomb Repressive Complexes 1" EXACT []
+synonym: "Polycomb-repressive complex 1" EXACT []
+synonym: "PRC1" EXACT []
+xref: BEL:"PRC1 Maintenance Complex"
+xref: GO:0035102
+xref: MEDSCAN:urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd
+xref: NCIT:C19866
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:1066 ! BMI1
+relationship: has_part HGNC:1552 ! CBX2
+relationship: has_part HGNC:1554 ! CBX4
+relationship: has_part HGNC:15962 ! CBX8
+relationship: has_part HGNC:12929 ! PCGF2
+relationship: has_part HGNC:3182 ! PHC1
+relationship: has_part HGNC:3183 ! PHC2
+relationship: has_part HGNC:15682 ! PHC3
+relationship: has_part HGNC:8919 ! PHF1
+relationship: has_part HGNC:10018 ! RING1
+relationship: has_part HGNC:10061 ! RNF2
+relationship: has_part HGNC:19003 ! SCMH1
+relationship: has_part HGNC:12856 ! YY1
+relationship: has_part HGNC:12918 ! ZNF134
+
+[Term]
+id: FPLX:000387
+name: PRC2-complex
+synonym: "Polycomb Repressive Complex 2" EXACT []
+synonym: "Polycomb repressive complex 2" EXACT []
+synonym: "polycomb repressive complex 2" EXACT []
+synonym: "Polycomb repressive complex PRC2" EXACT []
+synonym: "Polycomb Repressive Complexes 2" EXACT []
+synonym: "Polycomb-repressive complex 2" EXACT []
+synonym: "PRC2" EXACT []
+xref: BEL:"PRC2 Initiation Complex"
+xref: GO:0035098
+xref: MEDSCAN:urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3188 ! EED
+relationship: has_part HGNC:3526 ! EZH1
+relationship: has_part HGNC:3527 ! EZH2
+relationship: has_part HGNC:17101 ! SUZ12
+
+[Term]
+id: FPLX:000388
+name: PRDX
+synonym: "Peroxiredoxin" EXACT []
+synonym: "peroxiredoxin" EXACT []
+synonym: "Peroxiredoxins" EXACT []
+synonym: "peroxiredoxins" EXACT []
+xref: BEL:"PRDX Family"
+xref: ECCODE:1.11.1.15
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9352 ! PRDX1
+relationship: inverse_is_a HGNC:9353 ! PRDX2
+relationship: inverse_is_a HGNC:9354 ! PRDX3
+relationship: inverse_is_a HGNC:17169 ! PRDX4
+relationship: inverse_is_a HGNC:9355 ! PRDX5
+relationship: inverse_is_a HGNC:16753 ! PRDX6
+
+[Term]
+id: FPLX:000389
+name: PRKAC
+synonym: "PKA catalytic subunit" EXACT []
+synonym: "PKA catalytic subunits" EXACT []
+synonym: "Protein kinase A catalytic subunit" EXACT []
+synonym: "protein kinase A catalytic subunit" EXACT []
+synonym: "Protein kinase A catalytic subunits" EXACT []
+synonym: "protein kinase A catalytic subunits" EXACT []
+xref: BEL:"PRKA Family"
+xref: SIGNOR:SIGNOR-PF17
+relationship: part_of FPLX:000363 ! PKA
+relationship: inverse_is_a HGNC:9380 ! PRKACA
+relationship: inverse_is_a HGNC:9381 ! PRKACB
+relationship: inverse_is_a HGNC:9382 ! PRKACG
+
+[Term]
+id: FPLX:000390
+name: PRKAR
+synonym: "PKA regulatory subunit" EXACT []
+synonym: "PKA regulatory subunits" EXACT []
+synonym: "Protein kinase A regulatory subunit" EXACT []
+synonym: "protein kinase A regulatory subunit" EXACT []
+synonym: "Protein kinase A regulatory subunits" EXACT []
+synonym: "protein kinase A regulatory subunits" EXACT []
+synonym: "rPKA" EXACT []
+xref: BEL:"PRKAR Family"
+xref: IP:IPR012198
+xref: RE:R-HSA-111921
+xref: RE:R-HSA-111923
+xref: RE:R-HSA-5610566
+xref: RE:R-HSA-5610568
+relationship: part_of FPLX:000363 ! PKA
+relationship: inverse_is_a HGNC:9388 ! PRKAR1A
+relationship: inverse_is_a HGNC:9390 ! PRKAR1B
+relationship: inverse_is_a HGNC:9391 ! PRKAR2A
+relationship: inverse_is_a HGNC:9392 ! PRKAR2B
+
+[Term]
+id: FPLX:000391
+name: PRKG
+synonym: "PKG" EXACT []
+synonym: "protein kinase G" EXACT []
+xref: BEL:"PRKG Family"
+xref: ECCODE:2.7.11.12
+xref: IP:IPR002374
+xref: IP:IPR035014
+xref: RE:R-HSA-418379
+xref: RE:R-HSA-4551456
+xref: RE:R-HSA-4551462
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9414 ! PRKG1
+relationship: inverse_is_a HGNC:9416 ! PRKG2
+
+[Term]
+id: FPLX:000392
+name: Propionyl-CoA-carboxylase
+synonym: "Propionyl-CoA carboxylase" EXACT []
+synonym: "propionyl-CoA carboxylase" EXACT []
+xref: BEL:"Propionyl CoA Carboxylase Complex"
+xref: ECCODE:6.4.1.3
+xref: RE:R-HSA-2993807
+xref: RE:R-HSA-2993809
+xref: RE:R-HSA-3323122
+xref: RE:R-HSA-3323155
+xref: RE:R-HSA-71025
+xref: RE:R-HSA-71026
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:8653 ! PCCA
+relationship: has_part HGNC:8654 ! PCCB
+
+[Term]
+id: FPLX:000393
+name: Protease
+synonym: "protease" EXACT []
+xref: NCIT:C16965
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000394
+name: Proteasome
+synonym: "proteasome endopeptidase" EXACT []
+synonym: "proteasome" EXACT []
+xref: BEL:"Proteasome Complex"
+xref: ECCODE:3.4.25.1
+xref: GO:0000502
+xref: MESH:D046988
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9530 ! PSMA1
+relationship: has_part HGNC:9531 ! PSMA2
+relationship: has_part HGNC:9532 ! PSMA3
+relationship: has_part HGNC:9533 ! PSMA4
+relationship: has_part HGNC:9534 ! PSMA5
+relationship: has_part HGNC:9535 ! PSMA6
+relationship: has_part HGNC:9536 ! PSMA7
+relationship: has_part HGNC:22985 ! PSMA8
+relationship: has_part HGNC:9537 ! PSMB1
+relationship: has_part HGNC:9538 ! PSMB10
+relationship: has_part HGNC:9539 ! PSMB2
+relationship: has_part HGNC:9540 ! PSMB3
+relationship: has_part HGNC:9541 ! PSMB4
+relationship: has_part HGNC:9542 ! PSMB5
+relationship: has_part HGNC:9543 ! PSMB6
+relationship: has_part HGNC:9544 ! PSMB7
+relationship: has_part HGNC:9545 ! PSMB8
+relationship: has_part HGNC:9546 ! PSMB9
+relationship: has_part HGNC:9547 ! PSMC1
+relationship: has_part HGNC:9548 ! PSMC2
+relationship: has_part HGNC:9549 ! PSMC3
+relationship: has_part HGNC:9551 ! PSMC4
+relationship: has_part HGNC:9552 ! PSMC5
+relationship: has_part HGNC:9553 ! PSMC6
+relationship: has_part HGNC:9554 ! PSMD1
+relationship: has_part HGNC:9555 ! PSMD10
+relationship: has_part HGNC:9556 ! PSMD11
+relationship: has_part HGNC:9557 ! PSMD12
+relationship: has_part HGNC:9558 ! PSMD13
+relationship: has_part HGNC:16889 ! PSMD14
+relationship: has_part HGNC:9559 ! PSMD2
+relationship: has_part HGNC:9560 ! PSMD3
+relationship: has_part HGNC:9561 ! PSMD4
+relationship: has_part HGNC:9563 ! PSMD5
+relationship: has_part HGNC:9564 ! PSMD6
+relationship: has_part HGNC:9565 ! PSMD7
+relationship: has_part HGNC:9566 ! PSMD8
+relationship: has_part HGNC:9567 ! PSMD9
+relationship: has_part HGNC:9568 ! PSME1
+relationship: has_part HGNC:9569 ! PSME2
+relationship: has_part HGNC:9570 ! PSME3
+relationship: has_part HGNC:9571 ! PSMF1
+relationship: has_part HGNC:10845 ! SEM1
+relationship: has_part HGNC:12628 ! USP5
+
+[Term]
+id: FPLX:000395
+name: PTGER
+synonym: "prostaglandin E receptor" EXACT []
+xref: BEL:"PTGER Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9593 ! PTGER1
+relationship: inverse_is_a HGNC:9594 ! PTGER2
+relationship: inverse_is_a HGNC:9595 ! PTGER3
+relationship: inverse_is_a HGNC:9596 ! PTGER4
+
+[Term]
+id: FPLX:000396
+name: PYG
+synonym: "Glycogen phosphorylase" EXACT []
+synonym: "Glycogen phosphorylases" EXACT []
+synonym: "glycogen phosphorylase" EXACT []
+synonym: "glycogen phosphorylases" EXACT []
+synonym: "PYG" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:9723 ! PYGB
+relationship: inverse_is_a HGNC:9725 ! PYGL
+relationship: inverse_is_a HGNC:9726 ! PYGM
+
+[Term]
+id: FPLX:000397
+name: RAB
+synonym: "Rab GTPase" EXACT []
+synonym: "Rab GTPases" EXACT []
+synonym: "rab GTPases" EXACT []
+synonym: "rab proteins" EXACT []
+synonym: "RAB" EXACT []
+synonym: "Rab" EXACT []
+synonym: "rab" EXACT []
+synonym: "Rabs" EXACT []
+xref: BEL:"RAB Family"
+xref: MEDSCAN:urn:agi-protfc:rab
+xref: NEXTPROT-FAMILY:03661
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9759 ! RAB10
+relationship: inverse_is_a HGNC:9760 ! RAB11A
+relationship: inverse_is_a HGNC:9761 ! RAB11B
+relationship: inverse_is_a HGNC:31332 ! RAB12
+relationship: inverse_is_a HGNC:9762 ! RAB13
+relationship: inverse_is_a HGNC:16524 ! RAB14
+relationship: inverse_is_a HGNC:20150 ! RAB15
+relationship: inverse_is_a HGNC:16523 ! RAB17
+relationship: inverse_is_a HGNC:14244 ! RAB18
+relationship: inverse_is_a HGNC:19982 ! RAB19
+relationship: inverse_is_a HGNC:9758 ! RAB1A
+relationship: inverse_is_a HGNC:18370 ! RAB1B
+relationship: inverse_is_a HGNC:23683 ! RAB1C
+relationship: inverse_is_a HGNC:18260 ! RAB20
+relationship: inverse_is_a HGNC:18263 ! RAB21
+relationship: inverse_is_a HGNC:9764 ! RAB22A
+relationship: inverse_is_a HGNC:14263 ! RAB23
+relationship: inverse_is_a HGNC:9765 ! RAB24
+relationship: inverse_is_a HGNC:18238 ! RAB25
+relationship: inverse_is_a HGNC:14259 ! RAB26
+relationship: inverse_is_a HGNC:9766 ! RAB27A
+relationship: inverse_is_a HGNC:9767 ! RAB27B
+relationship: inverse_is_a HGNC:9768 ! RAB28
+relationship: inverse_is_a HGNC:9763 ! RAB2A
+relationship: inverse_is_a HGNC:20246 ! RAB2B
+relationship: inverse_is_a HGNC:9770 ! RAB30
+relationship: inverse_is_a HGNC:9771 ! RAB31
+relationship: inverse_is_a HGNC:9772 ! RAB32
+relationship: inverse_is_a HGNC:9773 ! RAB33A
+relationship: inverse_is_a HGNC:16075 ! RAB33B
+relationship: inverse_is_a HGNC:16519 ! RAB34
+relationship: inverse_is_a HGNC:9774 ! RAB35
+relationship: inverse_is_a HGNC:9775 ! RAB36
+relationship: inverse_is_a HGNC:30268 ! RAB37
+relationship: inverse_is_a HGNC:9776 ! RAB38
+relationship: inverse_is_a HGNC:16521 ! RAB39A
+relationship: inverse_is_a HGNC:16499 ! RAB39B
+relationship: inverse_is_a HGNC:9777 ! RAB3A
+relationship: inverse_is_a HGNC:9778 ! RAB3B
+relationship: inverse_is_a HGNC:30269 ! RAB3C
+relationship: inverse_is_a HGNC:9779 ! RAB3D
+relationship: inverse_is_a HGNC:18283 ! RAB40A
+relationship: inverse_is_a HGNC:25410 ! RAB40AL
+relationship: inverse_is_a HGNC:18284 ! RAB40B
+relationship: inverse_is_a HGNC:18285 ! RAB40C
+relationship: inverse_is_a HGNC:18293 ! RAB41
+relationship: inverse_is_a HGNC:28702 ! RAB42
+relationship: inverse_is_a HGNC:19983 ! RAB43
+relationship: inverse_is_a HGNC:21068 ! RAB44
+relationship: inverse_is_a HGNC:9781 ! RAB4A
+relationship: inverse_is_a HGNC:9782 ! RAB4B
+relationship: inverse_is_a HGNC:9783 ! RAB5A
+relationship: inverse_is_a HGNC:9784 ! RAB5B
+relationship: inverse_is_a HGNC:9785 ! RAB5C
+relationship: inverse_is_a HGNC:9786 ! RAB6A
+relationship: inverse_is_a HGNC:14902 ! RAB6B
+relationship: inverse_is_a HGNC:16525 ! RAB6C
+relationship: inverse_is_a HGNC:9788 ! RAB7A
+relationship: inverse_is_a HGNC:30513 ! RAB7B
+relationship: inverse_is_a HGNC:9789 ! RAB29
+relationship: inverse_is_a HGNC:7007 ! RAB8A
+relationship: inverse_is_a HGNC:30273 ! RAB8B
+relationship: inverse_is_a HGNC:9792 ! RAB9A
+relationship: inverse_is_a HGNC:14090 ! RAB9B
+relationship: inverse_is_a HGNC:9799 ! RABL2A
+relationship: inverse_is_a HGNC:9800 ! RABL2B
+relationship: inverse_is_a HGNC:18072 ! RABL3
+relationship: inverse_is_a HGNC:21895 ! IFT22
+
+[Term]
+id: FPLX:000398
+name: RAC
+synonym: "RAC" EXACT []
+xref: BEL:"RAC Family"
+xref: NEXTPROT-FAMILY:03066
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9801 ! RAC1
+relationship: inverse_is_a HGNC:9802 ! RAC2
+relationship: inverse_is_a HGNC:9803 ! RAC3
+relationship: inverse_is_a HGNC:672 ! RHOG
+
+[Term]
+id: FPLX:000399
+name: RAF
+synonym: "RAF" EXACT []
+synonym: "Raf" EXACT []
+xref: BEL:"RAF Family"
+xref: NEXTPROT-FAMILY:03114
+xref: RE:R-HSA-5672708
+xref: RE:R-HSA-5672726
+xref: RE:R-HSA-5674134
+xref: RE:R-HSA-5674136
+is_a: FPLX:000282 ! MAP3K
+relationship: inverse_is_a HGNC:646 ! ARAF
+relationship: inverse_is_a HGNC:1097 ! BRAF
+relationship: inverse_is_a HGNC:9829 ! RAF1
+
+[Term]
+id: FPLX:000400
+name: RAL
+synonym: "RAL family" EXACT []
+synonym: "Ral family" EXACT []
+synonym: "RAL isoforms" EXACT []
+synonym: "Ral isoforms" EXACT []
+synonym: "RAL proteins" EXACT []
+synonym: "Ral proteins" EXACT []
+synonym: "RAL" EXACT []
+xref: IP:IPR028412
+xref: RE:R-HSA-170994
+xref: RE:R-HSA-170998
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9839 ! RALA
+relationship: inverse_is_a HGNC:9840 ! RALB
+
+[Term]
+id: FPLX:000401
+name: RAP1
+synonym: "Rap1" EXACT []
+xref: NEXTPROT-FAMILY:04773
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9855 ! RAP1A
+relationship: inverse_is_a HGNC:9857 ! RAP1B
+
+[Term]
+id: FPLX:000402
+name: RAPGEF
+synonym: "Rap guanine nucleotide exchange factor" EXACT []
+synonym: "Rap guanine nucleotide exchange factors" EXACT []
+synonym: "RapGEFs" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:4568 ! RAPGEF1
+relationship: inverse_is_a HGNC:16854 ! RAPGEF2
+
+[Term]
+id: FPLX:000403
+name: RAR
+synonym: "RAR" EXACT []
+synonym: "retinoic acid receptors" EXACT []
+xref: BEL:"RAR Family"
+xref: NCIT:C17532
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9864 ! RARA
+relationship: inverse_is_a HGNC:9865 ! RARB
+relationship: inverse_is_a HGNC:9866 ! RARG
+
+[Term]
+id: FPLX:000404
+name: RAS
+synonym: "Ras GTPase" EXACT []
+synonym: "RAS" EXACT []
+synonym: "Ras" EXACT []
+xref: BEL:"RAS Family"
+xref: MEDSCAN:urn:agi-aopfc:0000465
+xref: NCIT:C17061
+xref: NEXTPROT-FAMILY:03663
+xref: XFAM:PF00071
+xref: RE:R-HSA-109782
+xref: RE:R-HSA-109783
+xref: RE:R-HSA-109796
+xref: RE:R-HSA-167204
+xref: RE:R-HSA-6802607
+xref: RE:R-HSA-6802608
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6407 ! KRAS
+relationship: inverse_is_a HGNC:5173 ! HRAS
+relationship: inverse_is_a HGNC:7989 ! NRAS
+
+[Term]
+id: FPLX:000405
+name: RASA
+synonym: "RASA" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9871 ! RASA1
+relationship: inverse_is_a HGNC:9872 ! RASA2
+relationship: inverse_is_a HGNC:20331 ! RASA3
+
+[Term]
+id: FPLX:000406
+name: RASAL
+synonym: "RASAL" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9873 ! RASAL1
+relationship: inverse_is_a HGNC:9874 ! RASAL2
+relationship: inverse_is_a HGNC:26129 ! RASAL3
+
+[Term]
+id: FPLX:000407
+name: RasGAP
+synonym: "RasGAP" EXACT []
+synonym: "RasGAPs" EXACT []
+xref: XFAM:PF00616
+xref: RE:R-HSA-5658216
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000408
+name: RASGRF
+synonym: "RASGRF" EXACT []
+xref: RE:R-HSA-442734
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9875 ! RASGRF1
+relationship: inverse_is_a HGNC:9876 ! RASGRF2
+
+[Term]
+id: FPLX:000409
+name: RASGRP
+synonym: "RASGRP" EXACT []
+xref: RE:R-HSA-2685656
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9878 ! RASGRP1
+relationship: inverse_is_a HGNC:9879 ! RASGRP2
+relationship: inverse_is_a HGNC:14545 ! RASGRP3
+relationship: inverse_is_a HGNC:18958 ! RASGRP4
+
+[Term]
+id: FPLX:000410
+name: RASSF
+synonym: "RAS association domain family" EXACT []
+synonym: "Ras association domain family" EXACT []
+synonym: "RAS-association domain family" EXACT []
+synonym: "Ras-association domain family" EXACT []
+synonym: "RASSF family" EXACT []
+xref: IP:IPR033614
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9882 ! RASSF1
+relationship: inverse_is_a HGNC:9883 ! RASSF2
+relationship: inverse_is_a HGNC:14271 ! RASSF3
+relationship: inverse_is_a HGNC:20793 ! RASSF4
+relationship: inverse_is_a HGNC:17609 ! RASSF5
+relationship: inverse_is_a HGNC:20796 ! RASSF6
+relationship: inverse_is_a HGNC:1166 ! RASSF7
+relationship: inverse_is_a HGNC:13232 ! RASSF8
+relationship: inverse_is_a HGNC:15739 ! RASSF9
+relationship: inverse_is_a HGNC:33984 ! RASSF10
+
+[Term]
+id: FPLX:000411
+name: RFC
+synonym: "DNA replication factor C complex" EXACT []
+synonym: "DNA replication factor C" EXACT []
+synonym: "replication factor C" EXACT []
+synonym: "RF-C" EXACT []
+synonym: "RFC" EXACT []
+xref: BEL:"RFC Complex"
+xref: GO:0005663
+xref: MEDSCAN:urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e
+xref: RE:R-HSA-174454
+xref: RE:R-HSA-68436
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9969 ! RFC1
+relationship: has_part HGNC:9970 ! RFC2
+relationship: has_part HGNC:9971 ! RFC3
+relationship: has_part HGNC:9972 ! RFC4
+relationship: has_part HGNC:9973 ! RFC5
+
+[Term]
+id: FPLX:000412
+name: RFX
+synonym: "regulatory family X" EXACT []
+synonym: "RF-X" EXACT []
+synonym: "RFX family" EXACT []
+synonym: "RFX proteins" EXACT []
+synonym: "RFX" EXACT []
+xref: BEL:"RFX Family"
+xref: MEDSCAN:urn:agi-aopfc:0000157
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:9982 ! RFX1
+relationship: inverse_is_a HGNC:9983 ! RFX2
+relationship: inverse_is_a HGNC:9984 ! RFX3
+relationship: inverse_is_a HGNC:9985 ! RFX4
+relationship: inverse_is_a HGNC:9986 ! RFX5
+relationship: inverse_is_a HGNC:21478 ! RFX6
+relationship: inverse_is_a HGNC:25777 ! RFX7
+relationship: inverse_is_a HGNC:37253 ! RFX8
+
+[Term]
+id: FPLX:000413
+name: RGL
+synonym: "RAL guanine nucleotide dissociation stimulator like" EXACT []
+synonym: "Ral guanine nucleotide dissociation stimulator like" EXACT []
+synonym: "ral guanine nucleotide dissociation stimulator like" EXACT []
+synonym: "RALGDS-like" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:30281 ! RGL1
+relationship: inverse_is_a HGNC:9769 ! RGL2
+relationship: inverse_is_a HGNC:30282 ! RGL3
+
+[Term]
+id: FPLX:000414
+name: RHO
+synonym: "Rho family" EXACT []
+synonym: "RHO" EXACT []
+xref: BEL:"RHO Family"
+xref: MEDSCAN:urn:agi-aopfc:0000499
+xref: NEXTPROT-FAMILY:03668
+xref: RE:R-HSA-419160
+xref: RE:R-HSA-419161
+xref: RE:R-HSA-419164
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:667 ! RHOA
+relationship: inverse_is_a HGNC:668 ! RHOB
+relationship: inverse_is_a HGNC:669 ! RHOC
+
+[Term]
+id: FPLX:000415
+name: RhoGDI
+synonym: "Rho-GDI" EXACT []
+synonym: "RHOGDI" EXACT []
+synonym: "RhoGDI" EXACT []
+synonym: "rhoGDI" EXACT []
+synonym: "RhoGDIs" EXACT []
+xref: GO:0005094
+xref: IP:IPR000406
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:678 ! ARHGDIA
+relationship: inverse_is_a HGNC:679 ! ARHGDIB
+relationship: inverse_is_a HGNC:680 ! ARHGDIG
+
+[Term]
+id: FPLX:000416
+name: RNApo-I
+synonym: "Pol I" EXACT []
+synonym: "RNA polymerase 1" EXACT []
+synonym: "RNA polymerase I" EXACT []
+xref: BEL:"RNApo I Complex"
+xref: GO:0005736
+xref: NCIT:C95947
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:17264 ! POLR1A
+relationship: has_part HGNC:20454 ! POLR1B
+relationship: has_part HGNC:20194 ! POLR1C
+relationship: has_part HGNC:20422 ! POLR1D
+
+[Term]
+id: FPLX:000417
+name: RNApo-II
+synonym: "RNA polymerase II" EXACT []
+synonym: "RNAP II" EXACT []
+xref: BEL:"RNApo II Complex"
+xref: GO:0005665
+xref: MEDSCAN:urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4
+xref: NCIT:C95948
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:9187 ! POLR2A
+relationship: has_part HGNC:9188 ! POLR2B
+relationship: has_part HGNC:9189 ! POLR2C
+relationship: has_part HGNC:9191 ! POLR2D
+relationship: has_part HGNC:9192 ! POLR2E
+relationship: has_part HGNC:9193 ! POLR2F
+relationship: has_part HGNC:9194 ! POLR2G
+relationship: has_part HGNC:9195 ! POLR2H
+relationship: has_part HGNC:9196 ! POLR2I
+relationship: has_part HGNC:9197 ! POLR2J
+relationship: has_part HGNC:23208 ! POLR2J2
+relationship: has_part HGNC:9198 ! POLR2K
+relationship: has_part HGNC:9199 ! POLR2L
+
+[Term]
+id: FPLX:000418
+name: ROBO
+xref: SIGNOR:SIGNOR-PF14
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10249 ! ROBO1
+relationship: inverse_is_a HGNC:10250 ! ROBO2
+relationship: inverse_is_a HGNC:13433 ! ROBO3
+
+[Term]
+id: FPLX:000419
+name: ROCK
+synonym: "ROCK" EXACT []
+xref: BEL:"ROCK Family"
+xref: IP:IPR015008
+xref: IP:IPR020684
+xref: RE:R-HSA-419057
+xref: RE:R-HSA-4687776
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10251 ! ROCK1
+relationship: inverse_is_a HGNC:10252 ! ROCK2
+
+[Term]
+id: FPLX:000420
+name: ROR
+synonym: "receptor tyrosine kinase-like orphan receptor" EXACT []
+synonym: "receptor tyrosine kinase-like orphan receptors" EXACT []
+synonym: "ROR" EXACT []
+synonym: "RORs" EXACT []
+xref: BEL:"ROR Family"
+xref: IP:IPR016247
+xref: MEDSCAN:urn:agi-aopfc:0000286
+xref: NEXTPROT-FAMILY:03130
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10256 ! ROR1
+relationship: inverse_is_a HGNC:10257 ! ROR2
+
+[Term]
+id: FPLX:000421
+name: RPA
+synonym: "Replication protein A" EXACT []
+synonym: "replication protein A" EXACT []
+synonym: "RPA" EXACT []
+xref: RE:R-HSA-68462
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:10289 ! RPA1
+relationship: has_part HGNC:10290 ! RPA2
+relationship: has_part HGNC:10291 ! RPA3
+
+[Term]
+id: FPLX:000422
+name: RSK
+synonym: "RSK" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000329 ! P90RSK
+relationship: inverse_is_a FPLX:000328 ! P70S6K
+
+[Term]
+id: FPLX:000423
+name: RTK
+synonym: "RTKs" EXACT []
+xref: NCIT:C17660
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000424
+name: RXR
+synonym: "retinoid X receptors" EXACT []
+synonym: "retinoid-X receptor" EXACT []
+synonym: "RXR" EXACT []
+xref: BEL:"RXR Family"
+xref: GO:0004886
+xref: MEDSCAN:urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422
+xref: NCIT:C17534
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10477 ! RXRA
+relationship: inverse_is_a HGNC:10478 ! RXRB
+relationship: inverse_is_a HGNC:10479 ! RXRG
+
+[Term]
+id: FPLX:000425
+name: S100
+synonym: "S100" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000426 ! S100A
+relationship: inverse_is_a HGNC:10500 ! S100B
+relationship: inverse_is_a HGNC:1436 ! S100G
+relationship: inverse_is_a HGNC:10504 ! S100P
+relationship: inverse_is_a HGNC:30367 ! S100Z
+
+[Term]
+id: FPLX:000426
+name: S100A
+synonym: "S100A" EXACT []
+synonym: "S100a" EXACT []
+xref: BEL:"S100A Family"
+is_a: FPLX:000425 ! S100
+relationship: inverse_is_a HGNC:20846 ! HRNR
+relationship: inverse_is_a HGNC:10486 ! S100A1
+relationship: inverse_is_a HGNC:10487 ! S100A10
+relationship: inverse_is_a HGNC:10488 ! S100A11
+relationship: inverse_is_a HGNC:10489 ! S100A12
+relationship: inverse_is_a HGNC:10490 ! S100A13
+relationship: inverse_is_a HGNC:18901 ! S100A14
+relationship: inverse_is_a HGNC:20441 ! S100A16
+relationship: inverse_is_a HGNC:10492 ! S100A2
+relationship: inverse_is_a HGNC:10493 ! S100A3
+relationship: inverse_is_a HGNC:10494 ! S100A4
+relationship: inverse_is_a HGNC:10495 ! S100A5
+relationship: inverse_is_a HGNC:10496 ! S100A6
+relationship: inverse_is_a HGNC:10497 ! S100A7
+relationship: inverse_is_a HGNC:21657 ! S100A7A
+relationship: inverse_is_a HGNC:10498 ! S100A8
+relationship: inverse_is_a HGNC:10499 ! S100A9
+relationship: inverse_is_a HGNC:31796 ! TCHHL1
+
+[Term]
+id: FPLX:000427
+name: S1PR
+synonym: "S1P receptor" EXACT []
+synonym: "S1PR" EXACT []
+synonym: "Sphingosine 1-phosphate receptor" EXACT []
+synonym: "sphingosine-1-phosphate receptors" EXACT []
+xref: BEL:"S1PR Family"
+xref: GO:0038036
+xref: IP:IPR004061
+xref: RE:R-HSA-419346
+xref: RE:R-HSA-419401
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3165 ! S1PR1
+relationship: inverse_is_a HGNC:3169 ! S1PR2
+relationship: inverse_is_a HGNC:3167 ! S1PR3
+relationship: inverse_is_a HGNC:3170 ! S1PR4
+relationship: inverse_is_a HGNC:14299 ! S1PR5
+
+[Term]
+id: FPLX:000428
+name: SAA
+synonym: "SAA" EXACT []
+xref: BEL:"SAA Family"
+xref: IP:IPR000096
+xref: NEXTPROT-FAMILY:03483
+xref: XFAM:PF00277
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10513 ! SAA1
+relationship: inverse_is_a HGNC:10514 ! SAA2
+relationship: inverse_is_a HGNC:10516 ! SAA4
+
+[Term]
+id: FPLX:000429
+name: SCD
+synonym: "stearoyl-CoA 9-desaturase" EXACT []
+synonym: "Stearoyl-CoA desaturase" EXACT []
+synonym: "stearoyl-CoA desaturase" EXACT []
+xref: BEL:"SCD Family"
+xref: ECCODE:1.14.19.1
+xref: IP:IPR001522
+xref: IP:IPR015876
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10571 ! SCD
+relationship: inverse_is_a HGNC:21088 ! SCD5
+
+[Term]
+id: FPLX:000430
+name: SERCA
+synonym: "sarcoplasmic/endoplasmic reticulum calcium ATPase" EXACT []
+synonym: "SERCA" EXACT []
+synonym: "SERCAs" EXACT []
+synonym: "SR Ca(2+)-ATPase" EXACT []
+xref: BEL:"ATP2A Family"
+xref: IP:IPR005782
+xref: MEDSCAN:urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase
+xref: RE:R-HSA-418312
+xref: RE:R-HSA-427905
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:811 ! ATP2A1
+relationship: inverse_is_a HGNC:812 ! ATP2A2
+relationship: inverse_is_a HGNC:813 ! ATP2A3
+
+[Term]
+id: FPLX:000431
+name: SERPINB
+synonym: "Clade B serpin" EXACT []
+synonym: "clade B serpins" EXACT []
+synonym: "ov-serpins" EXACT []
+xref: BEL:"SERPINB Family"
+xref: NEXTPROT-FAMILY:03579
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3311 ! SERPINB1
+relationship: inverse_is_a HGNC:8584 ! SERPINB2
+relationship: inverse_is_a HGNC:10569 ! SERPINB3
+relationship: inverse_is_a HGNC:10570 ! SERPINB4
+relationship: inverse_is_a HGNC:8949 ! SERPINB5
+relationship: inverse_is_a HGNC:8950 ! SERPINB6
+relationship: inverse_is_a HGNC:13902 ! SERPINB7
+relationship: inverse_is_a HGNC:8952 ! SERPINB8
+relationship: inverse_is_a HGNC:8955 ! SERPINB9
+relationship: inverse_is_a HGNC:8942 ! SERPINB10
+relationship: inverse_is_a HGNC:14221 ! SERPINB11
+relationship: inverse_is_a HGNC:14220 ! SERPINB12
+relationship: inverse_is_a HGNC:8944 ! SERPINB13
+
+[Term]
+id: FPLX:000432
+name: SHC
+synonym: "Shc family" EXACT []
+synonym: "SHC" EXACT []
+synonym: "Shc" EXACT []
+xref: IP:IPR006019
+xref: MEDSCAN:urn:agi-protfc:shc%20protein
+xref: RE:R-HSA-167023
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:10840 ! SHC1
+relationship: inverse_is_a HGNC:29869 ! SHC2
+relationship: inverse_is_a HGNC:18181 ! SHC3
+relationship: inverse_is_a HGNC:16743 ! SHC4
+
+[Term]
+id: FPLX:000433
+name: SIK
+synonym: "SIK" EXACT []
+synonym: "salt inducible kinase" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11142 ! SIK1
+relationship: inverse_is_a HGNC:21680 ! SIK2
+relationship: inverse_is_a HGNC:29165 ! SIK3
+
+[Term]
+id: FPLX:000434
+name: SLC2A
+synonym: "glucose transporter" EXACT []
+synonym: "glucose transporters" EXACT []
+synonym: "GLUT" EXACT []
+synonym: "SLC2" EXACT []
+xref: BEL:"SLC2A Family"
+xref: GO:0005355
+xref: NEXTPROT-FAMILY:02159
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11005 ! SLC2A1
+relationship: inverse_is_a HGNC:11006 ! SLC2A2
+relationship: inverse_is_a HGNC:11007 ! SLC2A3
+relationship: inverse_is_a HGNC:11009 ! SLC2A4
+relationship: inverse_is_a HGNC:11010 ! SLC2A5
+relationship: inverse_is_a HGNC:11011 ! SLC2A6
+relationship: inverse_is_a HGNC:13445 ! SLC2A7
+relationship: inverse_is_a HGNC:13812 ! SLC2A8
+relationship: inverse_is_a HGNC:13446 ! SLC2A9
+relationship: inverse_is_a HGNC:13444 ! SLC2A10
+relationship: inverse_is_a HGNC:14239 ! SLC2A11
+relationship: inverse_is_a HGNC:18067 ! SLC2A12
+relationship: inverse_is_a HGNC:18301 ! SLC2A14
+
+[Term]
+id: FPLX:000435
+name: SLRP
+synonym: "SLRP" EXACT []
+synonym: "SLRPs" EXACT []
+synonym: "SLRR" EXACT []
+synonym: "SLRRs" EXACT []
+synonym: "small leucine rich proteoglycan family" EXACT []
+synonym: "small leucine rich proteoglycan" EXACT []
+synonym: "small leucine rich proteoglycans" EXACT []
+synonym: "small leucine-rich proteoglycan family" EXACT []
+synonym: "small leucine-rich proteoglycan" EXACT []
+synonym: "small leucine-rich proteoglycans" EXACT []
+xref: NEXTPROT-FAMILY:03672
+xref: SIGNOR:SIGNOR-PF31
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000436 ! SLRP_1
+relationship: inverse_is_a FPLX:000437 ! SLRP_2
+relationship: inverse_is_a FPLX:000438 ! SLRP_3
+relationship: inverse_is_a FPLX:000439 ! SLRP_4
+relationship: inverse_is_a FPLX:000440 ! SLRP_5
+
+[Term]
+id: FPLX:000436
+name: SLRP-1
+xref: NEXTPROT-FAMILY:03673
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:1044 ! BGN
+relationship: inverse_is_a HGNC:2705 ! DCN
+relationship: inverse_is_a HGNC:14872 ! ASPN
+relationship: inverse_is_a HGNC:3154 ! ECM2
+
+[Term]
+id: FPLX:000437
+name: SLRP-2
+xref: NEXTPROT-FAMILY:03674
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:3774 ! FMOD
+relationship: inverse_is_a HGNC:6724 ! LUM
+relationship: inverse_is_a HGNC:9357 ! PRELP
+relationship: inverse_is_a HGNC:6309 ! KERA
+relationship: inverse_is_a HGNC:8134 ! OMD
+
+[Term]
+id: FPLX:000438
+name: SLRP-3
+xref: NEXTPROT-FAMILY:03675
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:3053 ! EPYC
+relationship: inverse_is_a HGNC:8158 ! OPTC
+relationship: inverse_is_a HGNC:8126 ! OGN
+
+[Term]
+id: FPLX:000439
+name: SLRP-4
+xref: NEXTPROT-FAMILY:03676
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:1909 ! CHAD
+relationship: inverse_is_a HGNC:8082 ! NYX
+relationship: inverse_is_a HGNC:28850 ! TSKU
+
+[Term]
+id: FPLX:000440
+name: SLRP-5
+xref: NEXTPROT-FAMILY:03677
+is_a: FPLX:000435 ! SLRP
+relationship: inverse_is_a HGNC:23174 ! PODN
+relationship: inverse_is_a HGNC:26275 ! PODNL1
+
+[Term]
+id: FPLX:000441
+name: SMAD
+synonym: "SMAD" EXACT []
+synonym: "Smad" EXACT []
+synonym: "smad" EXACT []
+xref: BEL:"SMAD Family"
+xref: IP:IPR001132
+xref: IP:IPR013019
+xref: IP:IPR013790
+xref: MEDSCAN:urn:agi-aopfc:0000159
+xref: MEDSCAN:urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6767 ! SMAD1
+relationship: inverse_is_a HGNC:6770 ! SMAD4
+relationship: inverse_is_a HGNC:6771 ! SMAD5
+relationship: inverse_is_a HGNC:6772 ! SMAD6
+relationship: inverse_is_a HGNC:6773 ! SMAD7
+relationship: inverse_is_a HGNC:6774 ! SMAD9
+relationship: inverse_is_a FPLX:000443 ! SMAD2_3
+relationship: inverse_is_a FPLX:000442 ! SMAD1_5_9
+
+[Term]
+id: FPLX:000442
+name: SMAD1-5-9
+xref: SIGNOR:SIGNOR-PF35
+is_a: FPLX:000441 ! SMAD
+relationship: inverse_is_a HGNC:6767 ! SMAD1
+relationship: inverse_is_a HGNC:6771 ! SMAD5
+relationship: inverse_is_a HGNC:6774 ! SMAD9
+
+[Term]
+id: FPLX:000443
+name: SMAD2-3
+synonym: "SMAD 2/3" EXACT []
+synonym: "SMAD2/3" EXACT []
+synonym: "Smad2/3" EXACT []
+xref: MEDSCAN:urn:agi-complex:SMAD2%2f3
+xref: RE:R-HSA-171172
+xref: RE:R-HSA-171182
+xref: RE:R-HSA-177105
+xref: RE:R-HSA-2176482
+xref: RE:R-HSA-2187329
+xref: RE:R-HSA-2187387
+is_a: FPLX:000441 ! SMAD
+relationship: inverse_is_a HGNC:6768 ! SMAD2
+relationship: inverse_is_a HGNC:6769 ! SMAD3
+
+[Term]
+id: FPLX:000444
+name: SMC1
+synonym: "SMC1" EXACT []
+synonym: "Smc1" EXACT []
+xref: BEL:"SMC1 Family"
+xref: NEXTPROT-FAMILY:03686
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11111 ! SMC1A
+relationship: inverse_is_a HGNC:11112 ! SMC1B
+
+[Term]
+id: FPLX:000445
+name: SMURF
+xref: SIGNOR:SIGNOR-PF29
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:16807 ! SMURF1
+relationship: inverse_is_a HGNC:16809 ! SMURF2
+
+[Term]
+id: FPLX:000446
+name: SNAI
+synonym: "SNAI family" EXACT []
+synonym: "SNAI" EXACT []
+xref: BEL:"SNAI Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11128 ! SNAI1
+relationship: inverse_is_a HGNC:11094 ! SNAI2
+relationship: inverse_is_a HGNC:18411 ! SNAI3
+
+[Term]
+id: FPLX:000447
+name: SOD
+synonym: "SOD" EXACT []
+xref: BEL:"Cu-Zn SOD Family"
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11179 ! SOD1
+relationship: inverse_is_a HGNC:11180 ! SOD2
+relationship: inverse_is_a HGNC:11181 ! SOD3
+
+[Term]
+id: FPLX:000448
+name: SOS
+synonym: "SOS" EXACT []
+xref: BEL:"SOS Family"
+xref: RE:R-HSA-167215
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11187 ! SOS1
+relationship: inverse_is_a HGNC:11188 ! SOS2
+
+[Term]
+id: FPLX:000449
+name: SPRED
+synonym: "SPRED" EXACT []
+xref: IP:IPR023337
+xref: RE:R-HSA-5658219
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:20249 ! SPRED1
+relationship: inverse_is_a HGNC:17722 ! SPRED2
+relationship: inverse_is_a HGNC:31041 ! SPRED3
+
+[Term]
+id: FPLX:000450
+name: SPRY
+synonym: "SPRY" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11269 ! SPRY1
+relationship: inverse_is_a HGNC:11270 ! SPRY2
+relationship: inverse_is_a HGNC:11271 ! SPRY3
+relationship: inverse_is_a HGNC:15533 ! SPRY4
+
+[Term]
+id: FPLX:000451
+name: SRC
+synonym: "SFK" EXACT []
+synonym: "Src family kinase" EXACT []
+synonym: "Src family" EXACT []
+synonym: "src kinases" EXACT []
+synonym: "SRC-family kinases" EXACT []
+synonym: "Src-kinases" EXACT []
+xref: BEL:"SRC Family"
+xref: MEDSCAN:urn:agi-aopfc:0000509
+xref: NEXTPROT-FAMILY:03131
+xref: SIGNOR:SIGNOR-PF32
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3697 ! FGR
+relationship: inverse_is_a HGNC:4037 ! FYN
+relationship: inverse_is_a HGNC:11283 ! SRC
+relationship: inverse_is_a HGNC:12841 ! YES1
+
+[Term]
+id: FPLX:000452
+name: SREBF
+synonym: "SREBF family" EXACT []
+synonym: "SREBF" EXACT []
+synonym: "sterol regulatory element binding protein" EXACT []
+synonym: "sterol regulatory element-binding factor" EXACT []
+xref: BEL:"SREBF Family"
+xref: MEDSCAN:urn:agi-protfc:sterol%20regulatory%20element%20binding%20protein
+xref: RE:R-HSA-1655720
+xref: RE:R-HSA-1655725
+xref: RE:R-HSA-1655726
+xref: RE:R-HSA-1655730
+xref: RE:R-HSA-1655732
+xref: RE:R-HSA-1655734
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11289 ! SREBF1
+relationship: inverse_is_a HGNC:11290 ! SREBF2
+
+[Term]
+id: FPLX:000453
+name: STAT
+synonym: "STAT" EXACT []
+synonym: "STATs" EXACT []
+xref: BEL:"STAT Family"
+xref: IP:IPR001217
+xref: IP:IPR012345
+xref: IP:IPR013799
+xref: IP:IPR013800
+xref: IP:IPR013801
+xref: IP:IPR015988
+xref: MEDSCAN:urn:agi-aopfc:0000163
+xref: MEDSCAN:urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15
+xref: NCIT:C19618
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11362 ! STAT1
+relationship: inverse_is_a HGNC:11363 ! STAT2
+relationship: inverse_is_a HGNC:11364 ! STAT3
+relationship: inverse_is_a HGNC:11365 ! STAT4
+relationship: inverse_is_a HGNC:11368 ! STAT6
+relationship: inverse_is_a FPLX:000454 ! STAT5
+
+[Term]
+id: FPLX:000454
+name: STAT5
+synonym: "STAT5" EXACT []
+synonym: "Stat5" EXACT []
+xref: BEL:"STAT5 Family"
+xref: MEDSCAN:urn:agi-protfc:STAT5%20protein
+xref: RE:R-HSA-1469978
+xref: RE:R-HSA-452094
+xref: RE:R-HSA-507919
+xref: RE:R-HSA-507929
+xref: RE:R-HSA-508012
+xref: RE:R-HSA-8865622
+is_a: FPLX:000453 ! STAT
+relationship: inverse_is_a HGNC:11366 ! STAT5A
+relationship: inverse_is_a HGNC:11367 ! STAT5B
+
+[Term]
+id: FPLX:000455
+name: STT3
+synonym: "STT3" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:6172 ! STT3A
+relationship: inverse_is_a HGNC:30611 ! STT3B
+
+[Term]
+id: FPLX:000456
+name: Sulfonylurea-receptor
+synonym: "Sulfonylurea Receptor" EXACT []
+synonym: "sulfonylurea receptor" EXACT []
+synonym: "sulfonylurea receptors" EXACT []
+synonym: "SUR" EXACT []
+xref: BEL:"Sulfonylurea Receptor Family"
+xref: GO:0008281
+xref: IP:IPR000388
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:59 ! ABCC8
+relationship: inverse_is_a HGNC:60 ! ABCC9
+
+[Term]
+id: FPLX:000457
+name: SWI-SNF
+synonym: "SWI and SNF complex" EXACT []
+synonym: "SWI/SNF complex" EXACT []
+synonym: "SWI/SNF" EXACT []
+synonym: "SWI/SNF-like" EXACT []
+xref: BEL:"SWI/SNF Complex"
+xref: MEDSCAN:urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861
+xref: MEDSCAN:urn:agi-protfc:chromatin%20remodeling%20complex
+xref: MEDSCAN:urn:agi-protfc:SWI%2fSNF%20family
+xref: NCIT:C20591
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:11110 ! ARID1A
+relationship: has_part HGNC:18040 ! ARID1B
+relationship: has_part HGNC:11097 ! SMARCA1
+relationship: has_part HGNC:11098 ! SMARCA2
+relationship: has_part HGNC:11100 ! SMARCA4
+relationship: has_part HGNC:11101 ! SMARCA5
+relationship: has_part HGNC:11103 ! SMARCB1
+relationship: has_part HGNC:11104 ! SMARCC1
+relationship: has_part HGNC:11105 ! SMARCC2
+relationship: has_part HGNC:11106 ! SMARCD1
+relationship: has_part HGNC:11107 ! SMARCD2
+relationship: has_part HGNC:11108 ! SMARCD3
+relationship: has_part HGNC:11109 ! SMARCE1
+relationship: has_part HGNC:24124 ! ACTL6A
+relationship: has_part HGNC:160 ! ACTL6B
+relationship: has_part HGNC:11099 ! HLTF
+
+[Term]
+id: FPLX:000458
+name: TAOK
+xref: SIGNOR:SIGNOR-PF21
+is_a: FPLX:000282 ! MAP3K
+relationship: inverse_is_a HGNC:29259 ! TAOK1
+relationship: inverse_is_a HGNC:16835 ! TAOK2
+relationship: inverse_is_a HGNC:18133 ! TAOK3
+
+[Term]
+id: FPLX:000459
+name: TAP
+synonym: "TAP transporter" EXACT []
+synonym: "TAP" EXACT []
+xref: BEL:"TAP Family"
+xref: GO:0042825
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:43 ! TAP1
+relationship: inverse_is_a HGNC:44 ! TAP2
+relationship: inverse_is_a HGNC:50 ! ABCB9
+
+[Term]
+id: FPLX:000460
+name: TCF-LEF
+synonym: "T-cell factor (TCF)/lymphoid enhancer factor" EXACT []
+synonym: "TCF" EXACT []
+synonym: "Tcf" EXACT []
+synonym: "Tcf/Lef" EXACT []
+xref: BEL:"TCF/LEF Family"
+xref: IP:IPR013558
+xref: IP:IPR024940
+xref: NEXTPROT-FAMILY:03943
+xref: RE:R-HSA-3299546
+xref: RE:R-HSA-5323539
+xref: RE:R-HSA-8944354
+xref: RE:R-HSA-8951427
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:6551 ! LEF1
+relationship: inverse_is_a HGNC:11639 ! TCF7
+relationship: inverse_is_a HGNC:11640 ! TCF7L1
+relationship: inverse_is_a HGNC:11641 ! TCF7L2
+
+[Term]
+id: FPLX:000461
+name: TCR
+synonym: "TCR" EXACT []
+xref: MESH:D011948
+xref: NCIT:C17065
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:12027 ! TRA
+relationship: has_part HGNC:12155 ! TRB
+relationship: has_part HGNC:12252 ! TRD
+relationship: has_part HGNC:12271 ! TRG
+
+[Term]
+id: FPLX:000462
+name: TEAD
+xref: SIGNOR:SIGNOR-PF22
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11714 ! TEAD1
+relationship: inverse_is_a HGNC:11715 ! TEAD2
+relationship: inverse_is_a HGNC:11716 ! TEAD3
+relationship: inverse_is_a HGNC:11717 ! TEAD4
+
+[Term]
+id: FPLX:000463
+name: TFAP2
+synonym: "AP-2 transcription factor" EXACT []
+synonym: "Transcription factor AP-2" EXACT []
+synonym: "transcription factor AP-2" EXACT []
+xref: BEL:"TFAP2 Family"
+xref: IP:IPR004979
+xref: IP:IPR013854
+xref: NEXTPROT-FAMILY:00209
+xref: RE:R-HSA-8864283
+xref: RE:R-HSA-8864286
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11742 ! TFAP2A
+relationship: inverse_is_a HGNC:11743 ! TFAP2B
+relationship: inverse_is_a HGNC:11744 ! TFAP2C
+relationship: inverse_is_a HGNC:15581 ! TFAP2D
+relationship: inverse_is_a HGNC:30774 ! TFAP2E
+
+[Term]
+id: FPLX:000464
+name: TFDP
+synonym: "DP complex" EXACT []
+synonym: "TFDP" EXACT []
+synonym: "transcription factor DP" EXACT []
+xref: BEL:"TFDP Family"
+xref: RE:R-HSA-1362227
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11749 ! TFDP1
+relationship: inverse_is_a HGNC:11751 ! TFDP2
+
+[Term]
+id: FPLX:000465
+name: TGFB
+synonym: "TGF beta" EXACT []
+synonym: "TGF β" EXACT []
+synonym: "TGF-b" EXACT []
+synonym: "TGF-beta family" EXACT []
+synonym: "TGF-beta" EXACT []
+synonym: "TGF-β" EXACT []
+synonym: "TGFB family" EXACT []
+synonym: "TGFB" EXACT []
+synonym: "TGFbeta" EXACT []
+synonym: "TGFβ" EXACT []
+synonym: "transforming growth factor beta" EXACT []
+synonym: "transforming growth factor β" EXACT []
+synonym: "transforming growth factor-beta" EXACT []
+synonym: "transforming growth factor-β" EXACT []
+xref: BEL:"TGFB Family"
+xref: IP:IPR015615
+xref: IP:IPR016319
+xref: MEDSCAN:urn:agi-aopfc:0000423
+xref: NEXTPROT-FAMILY:03989
+xref: RE:R-HSA-114657
+xref: RE:R-HSA-2395330
+xref: SIGNOR:SIGNOR-PF5
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11766 ! TGFB1
+relationship: inverse_is_a HGNC:11768 ! TGFB2
+relationship: inverse_is_a HGNC:11769 ! TGFB3
+
+[Term]
+id: FPLX:000466
+name: TGFBR
+synonym: "TGF beta receptor" EXACT []
+synonym: "TGF β receptor" EXACT []
+synonym: "TGF-beta receptor" EXACT []
+synonym: "TGF-beta receptors" EXACT []
+synonym: "TGF-β receptor" EXACT []
+synonym: "TGF-β receptors" EXACT []
+synonym: "TGFBR family" EXACT []
+synonym: "TGFBR" EXACT []
+synonym: "TGFβ receptor" EXACT []
+synonym: "TGFβ receptors" EXACT []
+xref: MEDSCAN:urn:agi-aopfc:0000294
+xref: MEDSCAN:urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11772 ! TGFBR1
+relationship: inverse_is_a HGNC:11773 ! TGFBR2
+relationship: inverse_is_a HGNC:11774 ! TGFBR3
+
+[Term]
+id: FPLX:000467
+name: THBS
+synonym: "thrombospondin protein" EXACT []
+synonym: "Thrombospondin" EXACT []
+synonym: "thrombospondin" EXACT []
+synonym: "Thrombospondins" EXACT []
+synonym: "thrombospondins" EXACT []
+xref: BEL:"THBS Family"
+xref: IP:IPR003367
+xref: IP:IPR008859
+xref: IP:IPR017897
+xref: IP:IPR028974
+xref: MEDSCAN:urn:agi-protfc:thrombospondins
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11785 ! THBS1
+relationship: inverse_is_a HGNC:11786 ! THBS2
+relationship: inverse_is_a HGNC:11787 ! THBS3
+relationship: inverse_is_a HGNC:11788 ! THBS4
+relationship: inverse_is_a HGNC:2227 ! COMP
+
+[Term]
+id: FPLX:000468
+name: THR
+synonym: "thyroid hormone receptor" EXACT []
+xref: BEL:"THR Family"
+xref: NCIT:C17078
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11796 ! THRA
+relationship: inverse_is_a HGNC:11799 ! THRB
+
+[Term]
+id: FPLX:000469
+name: Thrombin-antithrombin
+synonym: "thrombin-anti-thrombin III complexes" EXACT []
+xref: BEL:"Thrombin Antithrombin Complex"
+xref: RE:R-HSA-140812
+xref: RE:R-HSA-140871
+xref: RE:R-HSA-140874
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:3535 ! F2
+relationship: has_part HGNC:775 ! SERPINC1
+
+[Term]
+id: FPLX:000470
+name: TIAM
+synonym: "TIAM" EXACT []
+xref: NEXTPROT-FAMILY:04014
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11805 ! TIAM1
+relationship: inverse_is_a HGNC:11806 ! TIAM2
+
+[Term]
+id: FPLX:000471
+name: TIF-IB
+synonym: "TIF-IB" EXACT []
+xref: BEL:"TIF IB Complex"
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:11532 ! TAF1A
+relationship: has_part HGNC:11533 ! TAF1B
+relationship: has_part HGNC:11534 ! TAF1C
+relationship: has_part HGNC:11588 ! TBP
+
+[Term]
+id: FPLX:000472
+name: TLR
+synonym: "TLR" EXACT []
+xref: MEDSCAN:urn:agi-aopfc:0000296
+xref: SIGNOR:SIGNOR-PF20
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11847 ! TLR1
+relationship: inverse_is_a HGNC:11848 ! TLR2
+relationship: inverse_is_a HGNC:11849 ! TLR3
+relationship: inverse_is_a HGNC:11850 ! TLR4
+relationship: inverse_is_a HGNC:11851 ! TLR5
+relationship: inverse_is_a HGNC:16711 ! TLR6
+relationship: inverse_is_a HGNC:15631 ! TLR7
+relationship: inverse_is_a HGNC:15632 ! TLR8
+relationship: inverse_is_a HGNC:15633 ! TLR9
+relationship: inverse_is_a HGNC:15634 ! TLR10
+
+[Term]
+id: FPLX:000473
+name: TN
+synonym: "Tenascin" EXACT []
+synonym: "tenascin" EXACT []
+xref: BEL:"TN Family"
+xref: NCIT:C104676
+xref: NEXTPROT-FAMILY:03964
+xref: RE:R-HSA-2672035
+xref: RE:R-HSA-2681744
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:5318 ! TNC
+relationship: inverse_is_a HGNC:22942 ! TNN
+relationship: inverse_is_a HGNC:11953 ! TNR
+relationship: inverse_is_a HGNC:11976 ! TNXB
+
+[Term]
+id: FPLX:000474
+name: TNF
+xref: NEXTPROT-FAMILY:04243
+xref: XFAM:PF00229
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000475
+name: TNFRSF
+synonym: "TNF-R superfamily" EXACT []
+synonym: "TNF-receptor family" EXACT []
+synonym: "TNFR family" EXACT []
+synonym: "TNFR subfamily" EXACT []
+synonym: "TNFR superfamily members" EXACT []
+synonym: "TNFR superfamily receptors" EXACT []
+synonym: "TNFR superfamily" EXACT []
+synonym: "TNFR" EXACT []
+xref: BEL:"TNFRSF Family"
+xref: MEDSCAN:urn:agi-aopfc:0000295
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11916 ! TNFRSF1A
+relationship: inverse_is_a HGNC:11917 ! TNFRSF1B
+relationship: inverse_is_a HGNC:11918 ! TNFRSF4
+relationship: inverse_is_a HGNC:11923 ! TNFRSF8
+relationship: inverse_is_a HGNC:11924 ! TNFRSF9
+relationship: inverse_is_a HGNC:11904 ! TNFRSF10A
+relationship: inverse_is_a HGNC:11905 ! TNFRSF10B
+relationship: inverse_is_a HGNC:11906 ! TNFRSF10C
+relationship: inverse_is_a HGNC:11907 ! TNFRSF10D
+relationship: inverse_is_a HGNC:11908 ! TNFRSF11A
+relationship: inverse_is_a HGNC:11909 ! TNFRSF11B
+relationship: inverse_is_a HGNC:18152 ! TNFRSF12A
+relationship: inverse_is_a HGNC:18153 ! TNFRSF13B
+relationship: inverse_is_a HGNC:17755 ! TNFRSF13C
+relationship: inverse_is_a HGNC:11912 ! TNFRSF14
+relationship: inverse_is_a HGNC:11913 ! TNFRSF17
+relationship: inverse_is_a HGNC:11914 ! TNFRSF18
+relationship: inverse_is_a HGNC:11915 ! TNFRSF19
+relationship: inverse_is_a HGNC:13469 ! TNFRSF21
+relationship: inverse_is_a HGNC:11910 ! TNFRSF25
+
+[Term]
+id: FPLX:000476
+name: TOP2
+synonym: "topoisomerase II" EXACT []
+xref: BEL:"TOP2 Family"
+xref: IP:IPR001154
+xref: IP:IPR001241
+xref: IP:IPR002205
+xref: IP:IPR012542
+xref: IP:IPR013506
+xref: IP:IPR013757
+xref: IP:IPR013758
+xref: IP:IPR013759
+xref: IP:IPR013760
+xref: IP:IPR018522
+xref: IP:IPR024946
+xref: IP:IPR031660
+xref: IP:IPR034157
+xref: NCIT:C18434
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:11989 ! TOP2A
+relationship: inverse_is_a HGNC:11990 ! TOP2B
+
+[Term]
+id: FPLX:000477
+name: Troponin
+synonym: "troponin complex" EXACT []
+synonym: "troponin" EXACT []
+synonym: "troponins" EXACT []
+xref: GO:0005861
+xref: MEDSCAN:urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086
+xref: RE:R-HSA-390583
+xref: RE:R-HSA-390585
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000478 ! Troponin_C
+relationship: has_part FPLX:000479 ! Troponin_I
+relationship: has_part FPLX:000480 ! Troponin_T
+
+[Term]
+id: FPLX:000478
+name: Troponin-C
+synonym: "cTnC" EXACT []
+synonym: "cTnI" EXACT []
+synonym: "TN-C" EXACT []
+synonym: "TnC" EXACT []
+synonym: "troponin C" EXACT []
+xref: RE:R-HSA-390532
+xref: RE:R-HSA-390587
+relationship: part_of FPLX:000477 ! Troponin
+relationship: inverse_is_a HGNC:11943 ! TNNC1
+relationship: inverse_is_a HGNC:11944 ! TNNC2
+
+[Term]
+id: FPLX:000479
+name: Troponin-I
+synonym: "TPNI" EXACT []
+synonym: "troponin I" EXACT []
+xref: NCIT:C17343
+xref: RE:R-HSA-390541
+relationship: part_of FPLX:000477 ! Troponin
+relationship: inverse_is_a HGNC:11945 ! TNNI1
+relationship: inverse_is_a HGNC:11946 ! TNNI2
+relationship: inverse_is_a HGNC:11947 ! TNNI3
+
+[Term]
+id: FPLX:000480
+name: Troponin-T
+synonym: "cTnT" EXACT []
+synonym: "TPNT" EXACT []
+synonym: "troponin T" EXACT []
+xref: IP:IPR027707
+xref: NCIT:C38041
+xref: RE:R-HSA-390546
+relationship: part_of FPLX:000477 ! Troponin
+relationship: inverse_is_a HGNC:11948 ! TNNT1
+relationship: inverse_is_a HGNC:11949 ! TNNT2
+relationship: inverse_is_a HGNC:11950 ! TNNT3
+
+[Term]
+id: FPLX:000481
+name: Tryptase
+synonym: "Tryptase" EXACT []
+synonym: "tryptase" EXACT []
+synonym: "tryptases" EXACT []
+xref: BEL:"Tryptase Family"
+xref: ECCODE:3.4.21.59
+xref: NCIT:C120030
+xref: NEXTPROT-FAMILY:02767
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12019 ! TPSAB1
+relationship: inverse_is_a HGNC:14120 ! TPSB2
+relationship: inverse_is_a HGNC:14118 ! TPSD1
+relationship: inverse_is_a HGNC:14134 ! TPSG1
+
+[Term]
+id: FPLX:000482
+name: TSC
+synonym: "TSC" EXACT []
+xref: RE:R-HSA-165175
+xref: RE:R-HSA-165180
+xref: RE:R-HSA-381855
+xref: RE:R-HSA-5672337
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12362 ! TSC1
+relationship: inverse_is_a HGNC:12363 ! TSC2
+
+[Term]
+id: FPLX:000483
+name: TUBA
+synonym: "alpha tubulin" EXACT []
+synonym: "TUBA" EXACT []
+synonym: "tubulin alpha chain" EXACT []
+synonym: "tubulin α chain" EXACT []
+synonym: "α tubulin" EXACT []
+xref: BEL:"TUBA Family"
+is_a: FPLX:000486 ! Tubulin
+relationship: inverse_is_a HGNC:20766 ! TUBA1A
+relationship: inverse_is_a HGNC:18809 ! TUBA1B
+relationship: inverse_is_a HGNC:20768 ! TUBA1C
+relationship: inverse_is_a HGNC:12408 ! TUBA3C
+relationship: inverse_is_a HGNC:24071 ! TUBA3D
+relationship: inverse_is_a HGNC:20765 ! TUBA3E
+relationship: inverse_is_a HGNC:12407 ! TUBA4A
+relationship: inverse_is_a HGNC:12410 ! TUBA8
+relationship: inverse_is_a HGNC:23534 ! TUBAL3
+
+[Term]
+id: FPLX:000484
+name: TUBB
+synonym: "Beta Tubulin" EXACT []
+synonym: "Beta tubulin" EXACT []
+synonym: "beta Tubulin" EXACT []
+synonym: "beta tubulin" EXACT []
+synonym: "Beta-Tubulin" EXACT []
+synonym: "Beta-tubulin" EXACT []
+synonym: "beta-Tubulin" EXACT []
+synonym: "beta-tubulin" EXACT []
+synonym: "TUBB" EXACT []
+synonym: "tubulin beta chain" EXACT []
+synonym: "tubulin beta" EXACT []
+synonym: "tubulin β chain" EXACT []
+synonym: "tubulin β" EXACT []
+xref: BEL:"TUBB Family"
+xref: IP:IPR002453
+xref: NCIT:C129655
+is_a: FPLX:000486 ! Tubulin
+relationship: inverse_is_a HGNC:20778 ! TUBB
+relationship: inverse_is_a HGNC:16257 ! TUBB1
+relationship: inverse_is_a HGNC:12412 ! TUBB2A
+relationship: inverse_is_a HGNC:30829 ! TUBB2B
+relationship: inverse_is_a HGNC:20772 ! TUBB3
+relationship: inverse_is_a HGNC:20774 ! TUBB4A
+relationship: inverse_is_a HGNC:20771 ! TUBB4B
+relationship: inverse_is_a HGNC:20776 ! TUBB6
+
+[Term]
+id: FPLX:000485
+name: TUBG
+synonym: "Gamma tubulin" EXACT []
+synonym: "gamma tubulin" EXACT []
+synonym: "gamma-tubulin" EXACT []
+synonym: "tubulin gamma" EXACT []
+synonym: "tubulin γ" EXACT []
+synonym: "γ tubulin" EXACT []
+synonym: "γ-tubulin" EXACT []
+xref: GO:0000930
+xref: IP:IPR002454
+is_a: FPLX:000486 ! Tubulin
+relationship: inverse_is_a HGNC:12417 ! TUBG1
+relationship: inverse_is_a HGNC:12419 ! TUBG2
+
+[Term]
+id: FPLX:000486
+name: Tubulin
+synonym: "tubulin" EXACT []
+xref: MEDSCAN:urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802
+xref: MEDSCAN:urn:agi-protfc:tubulin
+xref: NCIT:C17219
+xref: NEXTPROT-FAMILY:04239
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a FPLX:000483 ! TUBA
+relationship: inverse_is_a FPLX:000484 ! TUBB
+relationship: inverse_is_a FPLX:000485 ! TUBG
+relationship: inverse_is_a HGNC:16811 ! TUBD1
+relationship: inverse_is_a HGNC:20775 ! TUBE1
+
+[Term]
+id: FPLX:000487
+name: TXN
+synonym: "Thioredoxin" EXACT []
+synonym: "thioredoxin" EXACT []
+synonym: "thioredoxins" EXACT []
+xref: BEL:"TXN Family"
+xref: MEDSCAN:urn:agi-protfc:thioredoxin
+xref: NEXTPROT-FAMILY:04000
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12435 ! TXN
+relationship: inverse_is_a HGNC:17772 ! TXN2
+
+[Term]
+id: FPLX:000488
+name: TXNRD
+synonym: "Thioredoxin reductase" EXACT []
+synonym: "thioredoxin reductase" EXACT []
+xref: BEL:"TXNRD Family"
+xref: IP:IPR006338
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12437 ! TXNRD1
+relationship: inverse_is_a HGNC:18155 ! TXNRD2
+relationship: inverse_is_a HGNC:20667 ! TXNRD3
+
+[Term]
+id: FPLX:000489
+name: UBE2
+synonym: "E2 enzyme" EXACT []
+synonym: "E2 ubiquitin-conjugating enzyme" EXACT []
+synonym: "E2" EXACT []
+synonym: "UBE2" EXACT []
+synonym: "ubiquitin conjugating enzyme" EXACT []
+synonym: "ubiquitin-conjugating enzymes" EXACT []
+xref: BEL:"UBE2 Family"
+xref: ECCODE:2.3.2.23
+xref: GO:0019787
+xref: NEXTPROT-FAMILY:04282
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:1734 ! CDC34
+relationship: inverse_is_a HGNC:12472 ! UBE2A
+relationship: inverse_is_a HGNC:12473 ! UBE2B
+relationship: inverse_is_a HGNC:15937 ! UBE2C
+relationship: inverse_is_a HGNC:12474 ! UBE2D1
+relationship: inverse_is_a HGNC:12475 ! UBE2D2
+relationship: inverse_is_a HGNC:12476 ! UBE2D3
+relationship: inverse_is_a HGNC:21647 ! UBE2D4
+relationship: inverse_is_a HGNC:12477 ! UBE2E1
+relationship: inverse_is_a HGNC:12478 ! UBE2E2
+relationship: inverse_is_a HGNC:12479 ! UBE2E3
+relationship: inverse_is_a HGNC:12480 ! UBE2F
+relationship: inverse_is_a HGNC:12482 ! UBE2G1
+relationship: inverse_is_a HGNC:12483 ! UBE2G2
+relationship: inverse_is_a HGNC:12484 ! UBE2H
+relationship: inverse_is_a HGNC:12485 ! UBE2I
+relationship: inverse_is_a HGNC:17598 ! UBE2J1
+relationship: inverse_is_a HGNC:19268 ! UBE2J2
+relationship: inverse_is_a HGNC:12488 ! UBE2L3
+relationship: inverse_is_a HGNC:12490 ! UBE2L6
+relationship: inverse_is_a HGNC:12491 ! UBE2M
+relationship: inverse_is_a HGNC:12492 ! UBE2N
+relationship: inverse_is_a HGNC:31710 ! UBE2NL
+relationship: inverse_is_a HGNC:15698 ! UBE2Q1
+relationship: inverse_is_a HGNC:19907 ! UBE2R2
+relationship: inverse_is_a HGNC:17895 ! UBE2S
+relationship: inverse_is_a HGNC:12494 ! UBE2V1
+relationship: inverse_is_a HGNC:12495 ! UBE2V2
+relationship: inverse_is_a HGNC:25616 ! UBE2W
+
+[Term]
+id: FPLX:000490
+name: Ubiquitin
+synonym: "Ub" EXACT []
+synonym: "ub" EXACT []
+synonym: "Ubiquitin" EXACT []
+synonym: "ubiquitin" EXACT []
+xref: MEDSCAN:urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd
+xref: MEDSCAN:urn:agi-protfc:ubiquitin
+xref: NCIT:C17227
+xref: NEXTPROT-FAMILY:04276
+is_a: FPLX:000000 ! famplex
+
+[Term]
+id: FPLX:000491
+name: UGCG
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:12524 ! UGCG
+
+[Term]
+id: FPLX:000492
+name: UGT
+synonym: "UGT" EXACT []
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:12529 ! UGT1A
+relationship: inverse_is_a HGNC:12530 ! UGT1A1
+relationship: inverse_is_a HGNC:12534 ! UGT1A2P
+relationship: inverse_is_a HGNC:12535 ! UGT1A3
+relationship: inverse_is_a HGNC:12536 ! UGT1A4
+relationship: inverse_is_a HGNC:12537 ! UGT1A5
+relationship: inverse_is_a HGNC:12538 ! UGT1A6
+relationship: inverse_is_a HGNC:12539 ! UGT1A7
+relationship: inverse_is_a HGNC:12540 ! UGT1A8
+relationship: inverse_is_a HGNC:12541 ! UGT1A9
+relationship: inverse_is_a HGNC:12531 ! UGT1A10
+relationship: inverse_is_a HGNC:12532 ! UGT1A11P
+relationship: inverse_is_a HGNC:12533 ! UGT1A12P
+relationship: inverse_is_a HGNC:32191 ! UGT1A13P
+relationship: inverse_is_a HGNC:12542 ! UGT2A1
+relationship: inverse_is_a HGNC:28183 ! UGT2A2
+relationship: inverse_is_a HGNC:28528 ! UGT2A3
+relationship: inverse_is_a HGNC:12553 ! UGT2B4
+relationship: inverse_is_a HGNC:12554 ! UGT2B7
+relationship: inverse_is_a HGNC:12544 ! UGT2B10
+relationship: inverse_is_a HGNC:12545 ! UGT2B11
+relationship: inverse_is_a HGNC:12546 ! UGT2B15
+relationship: inverse_is_a HGNC:12547 ! UGT2B17
+relationship: inverse_is_a HGNC:12548 ! UGT2B24P
+relationship: inverse_is_a HGNC:12549 ! UGT2B25P
+relationship: inverse_is_a HGNC:12550 ! UGT2B26P
+relationship: inverse_is_a HGNC:12551 ! UGT2B27P
+relationship: inverse_is_a HGNC:13479 ! UGT2B28
+relationship: inverse_is_a HGNC:12552 ! UGT2B29P
+relationship: inverse_is_a HGNC:26625 ! UGT3A1
+relationship: inverse_is_a HGNC:27266 ! UGT3A2
+relationship: inverse_is_a HGNC:12555 ! UGT8
+
+[Term]
+id: FPLX:000493
+name: UGGT
+is_a: FPLX:000198 ! Glycosyltransferase
+relationship: inverse_is_a HGNC:15663 ! UGGT1
+relationship: inverse_is_a HGNC:15664 ! UGGT2
+
+[Term]
+id: FPLX:000494
+name: VAV
+synonym: "VAV family" EXACT []
+synonym: "Vav" EXACT []
+xref: BEL:"VAV Family"
+xref: MEDSCAN:urn:agi-aopfc:0000504
+xref: RE:R-HSA-2029115
+xref: RE:R-HSA-430172
+xref: RE:R-HSA-434632
+xref: RE:R-HSA-442272
+xref: RE:R-HSA-442295
+xref: RE:R-HSA-5218789
+xref: RE:R-HSA-5340329
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12657 ! VAV1
+relationship: inverse_is_a HGNC:12658 ! VAV2
+relationship: inverse_is_a HGNC:12659 ! VAV3
+
+[Term]
+id: FPLX:000495
+name: VEGF
+synonym: "vascular endothelial growth factor" EXACT []
+synonym: "VEGF" EXACT []
+xref: BEL:"VEGF Family"
+xref: NCIT:C129646
+xref: RE:R-HSA-195361
+xref: RE:R-HSA-195376
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12680 ! VEGFA
+relationship: inverse_is_a HGNC:12681 ! VEGFB
+relationship: inverse_is_a HGNC:12682 ! VEGFC
+relationship: inverse_is_a HGNC:3708 ! VEGFD
+relationship: inverse_is_a HGNC:8893 ! PGF
+
+[Term]
+id: FPLX:000496
+name: VEGFR
+synonym: "VEGF receptor" EXACT []
+synonym: "VEGF receptors" EXACT []
+synonym: "VEGFR ligand" EXACT []
+synonym: "VEGFR" EXACT []
+synonym: "VEGFRs" EXACT []
+xref: BEL:"VEGFR Family"
+xref: GO:0005172
+xref: NCIT:C17293
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:3763 ! FLT1
+relationship: inverse_is_a HGNC:3767 ! FLT4
+relationship: inverse_is_a HGNC:6307 ! KDR
+
+[Term]
+id: FPLX:000497
+name: Wnt
+synonym: "WNT" EXACT []
+synonym: "Wnt" EXACT []
+xref: BEL:"WNT Family"
+xref: IP:IPR005817
+xref: IP:IPR018161
+xref: MEDSCAN:urn:agi-aopfc:0000426
+xref: NEXTPROT-FAMILY:04686
+xref: XFAM:PF00110
+xref: RE:R-HSA-3238268
+xref: RE:R-HSA-3238374
+xref: RE:R-HSA-3247790
+xref: RE:R-HSA-3247824
+xref: RE:R-HSA-3247835
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:12774 ! WNT1
+relationship: inverse_is_a HGNC:12780 ! WNT2
+relationship: inverse_is_a HGNC:12781 ! WNT2B
+relationship: inverse_is_a HGNC:12782 ! WNT3
+relationship: inverse_is_a HGNC:15983 ! WNT3A
+relationship: inverse_is_a HGNC:12783 ! WNT4
+relationship: inverse_is_a HGNC:12784 ! WNT5A
+relationship: inverse_is_a HGNC:16265 ! WNT5B
+relationship: inverse_is_a HGNC:12785 ! WNT6
+relationship: inverse_is_a HGNC:12786 ! WNT7A
+relationship: inverse_is_a HGNC:12787 ! WNT7B
+relationship: inverse_is_a HGNC:12788 ! WNT8A
+relationship: inverse_is_a HGNC:12789 ! WNT8B
+relationship: inverse_is_a HGNC:12778 ! WNT9A
+relationship: inverse_is_a HGNC:12779 ! WNT9B
+relationship: inverse_is_a HGNC:13829 ! WNT10A
+relationship: inverse_is_a HGNC:12775 ! WNT10B
+relationship: inverse_is_a HGNC:12776 ! WNT11
+relationship: inverse_is_a HGNC:16267 ! WNT16
+
+[Term]
+id: FPLX:000498
+name: YBX
+synonym: "Y box binding protein" EXACT []
+synonym: "Y-box-binding protein" EXACT []
+synonym: "YBX protein family" EXACT []
+is_a: FPLX:000000 ! famplex
+relationship: inverse_is_a HGNC:8014 ! YBX1
+relationship: inverse_is_a HGNC:17948 ! YBX2
+relationship: inverse_is_a HGNC:2428 ! YBX3
+
+[Term]
+id: FPLX:000499
+name: ETC-complex-I-core
+xref: HGNC_GROUP:1149
+relationship: part_of FPLX:000501 ! ETC_complex_I
+relationship: has_part HGNC:7455 ! MT-ND1
+relationship: has_part HGNC:7456 ! MT-ND2
+relationship: has_part HGNC:7458 ! MT-ND3
+relationship: has_part HGNC:7459 ! MT-ND4
+relationship: has_part HGNC:7460 ! MT-ND4L
+relationship: has_part HGNC:7461 ! MT-ND5
+relationship: has_part HGNC:7462 ! MT-ND6
+relationship: has_part HGNC:7707 ! NDUFS1
+relationship: has_part HGNC:7708 ! NDUFS2
+relationship: has_part HGNC:7710 ! NDUFS3
+relationship: has_part HGNC:7714 ! NDUFS7
+relationship: has_part HGNC:7715 ! NDUFS8
+relationship: has_part HGNC:7716 ! NDUFV1
+relationship: has_part HGNC:7717 ! NDUFV2
+
+[Term]
+id: FPLX:000500
+name: ETC-complex-I-supernumerary
+xref: HGNC_GROUP:1150
+relationship: part_of FPLX:000501 ! ETC_complex_I
+relationship: has_part HGNC:7694 ! NDUFAB1
+relationship: has_part HGNC:7683 ! NDUFA1
+relationship: has_part HGNC:7685 ! NDUFA2
+relationship: has_part HGNC:7686 ! NDUFA3
+relationship: has_part HGNC:7688 ! NDUFA5
+relationship: has_part HGNC:7690 ! NDUFA6
+relationship: has_part HGNC:7691 ! NDUFA7
+relationship: has_part HGNC:7692 ! NDUFA8
+relationship: has_part HGNC:7693 ! NDUFA9
+relationship: has_part HGNC:7684 ! NDUFA10
+relationship: has_part HGNC:20371 ! NDUFA11
+relationship: has_part HGNC:23987 ! NDUFA12
+relationship: has_part HGNC:17194 ! NDUFA13
+relationship: has_part HGNC:7695 ! NDUFB1
+relationship: has_part HGNC:7697 ! NDUFB2
+relationship: has_part HGNC:7698 ! NDUFB3
+relationship: has_part HGNC:7699 ! NDUFB4
+relationship: has_part HGNC:7700 ! NDUFB5
+relationship: has_part HGNC:7701 ! NDUFB6
+relationship: has_part HGNC:7702 ! NDUFB7
+relationship: has_part HGNC:7703 ! NDUFB8
+relationship: has_part HGNC:7704 ! NDUFB9
+relationship: has_part HGNC:7696 ! NDUFB10
+relationship: has_part HGNC:20372 ! NDUFB11
+relationship: has_part HGNC:7705 ! NDUFC1
+relationship: has_part HGNC:7706 ! NDUFC2
+relationship: has_part HGNC:7711 ! NDUFS4
+relationship: has_part HGNC:7712 ! NDUFS5
+relationship: has_part HGNC:7713 ! NDUFS6
+relationship: has_part HGNC:7719 ! NDUFV3
+
+[Term]
+id: FPLX:000501
+name: ETC-complex-I
+xref: COMPLEXPORTAL:CPX-577
+xref: ECCODE:1.6.5.3
+xref: GO:0005747
+xref: HGNC_GROUP:640
+xref: MESH:D042967
+xref: NCIT:C118184
+is_a: FPLX:000000 ! famplex
+relationship: has_part FPLX:000499 ! ETC_complex_I_core
+relationship: has_part FPLX:000500 ! ETC_complex_I_supernumerary
+
+[Term]
+id: FPLX:000502
+name: ETC-complex-II
+synonym: "complex II" EXACT []
+synonym: "succinate dehydrogenase (ubiquinone)" EXACT []
+synonym: "succinate dehydrogenase" EXACT []
+xref: BEL:"Respiratory Chain Complex II"
+xref: COMPLEXPORTAL:CPX-561
+xref: ECCODE:1.3.5.1
+xref: GO:0005749
+xref: HGNC_GROUP:641
+xref: MESH:D042963
+xref: NCIT:C112049
+xref: RE:R-HSA-165631
+xref: RE:R-HSA-70990
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:10680 ! SDHA
+relationship: has_part HGNC:10681 ! SDHB
+relationship: has_part HGNC:10682 ! SDHC
+relationship: has_part HGNC:10683 ! SDHD
+
+[Term]
+id: FPLX:000503
+name: ETC-complex-III
+synonym: "complex III" EXACT []
+synonym: "cytochrome bc1 complex" EXACT []
+xref: BEL:"Respiratory Chain Complex III"
+xref: COMPLEXPORTAL:CPX-560
+xref: ECCODE:1.10.2.2
+xref: GO:0005750
+xref: GO:0045275
+xref: HGNC_GROUP:642
+xref: MESH:D014450
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2579 ! CYC1
+relationship: has_part HGNC:7427 ! MT-CYB
+relationship: has_part HGNC:12582 ! UQCRB
+relationship: has_part HGNC:12585 ! UQCRC1
+relationship: has_part HGNC:12586 ! UQCRC2
+relationship: has_part HGNC:12587 ! UQCRFS1
+relationship: has_part HGNC:12590 ! UQCRH
+relationship: has_part HGNC:29594 ! UQCRQ
+relationship: has_part HGNC:30863 ! UQCR10
+relationship: has_part HGNC:30862 ! UQCR11
+
+[Term]
+id: FPLX:000504
+name: ETC-complex-IV
+xref: ECCODE:1.9.3.1
+xref: GO:0005751
+xref: HGNC_GROUP:643
+xref: MESH:D003576
+xref: NCIT:C26034
+is_a: FPLX:000000 ! famplex
+relationship: has_part HGNC:2265 ! COX4I1
+relationship: has_part HGNC:16232 ! COX4I2
+relationship: has_part HGNC:2267 ! COX5A
+relationship: has_part HGNC:2269 ! COX5B
+relationship: has_part HGNC:2277 ! COX6A1
+relationship: has_part HGNC:2279 ! COX6A2
+relationship: has_part HGNC:2280 ! COX6B1
+relationship: has_part HGNC:24380 ! COX6B2
+relationship: has_part HGNC:2285 ! COX6C
+relationship: has_part HGNC:2287 ! COX7A1
+relationship: has_part HGNC:2288 ! COX7A2
+relationship: has_part HGNC:2291 ! COX7B
+relationship: has_part HGNC:24381 ! COX7B2
+relationship: has_part HGNC:2292 ! COX7C
+relationship: has_part HGNC:2294 ! COX8A
+relationship: has_part HGNC:24382 ! COX8C
+relationship: has_part HGNC:7419 ! MT-CO1
+relationship: has_part HGNC:7421 ! MT-CO2
+relationship: has_part HGNC:7422 ! MT-CO3
+
+[Term]
+id: FPLX:000505
+name: ETC-complex-V
+xref: ECCODE:3.6.3.14
+xref: GO:0005753
+xref: HGNC_GROUP:644
+xref: MESH:D025261
+is_a: FPLX:000000 ! famplex
+
diff --git a/famplex/resources/grounding_map.csv b/famplex/resources/grounding_map.csv
new file mode 100644
index 000000000..e52c1bcb9
--- /dev/null
+++ b/famplex/resources/grounding_map.csv
@@ -0,0 +1,2834 @@
+"AMPK (alpha 1, beta 1, gamma 1)",FPLX,000032,AMPK_A1B1G1
+"AMPK (alpha 1, beta 1, gamma 2)",FPLX,000033,AMPK_A1B1G2
+"AMPK (alpha 1, beta 1, gamma 3)",FPLX,000034,AMPK_A1B1G3
+"AMPK (alpha 1, beta 2, gamma 1)",FPLX,000035,AMPK_A1B2G1
+"AMPK (alpha 1, beta 2, gamma 2)",FPLX,000036,AMPK_A1B2G2
+"AMPK (alpha 1, beta 2, gamma 3)",FPLX,000037,AMPK_A1B2G3
+"AMPK (alpha 2, beta 1, gamma 1)",FPLX,000038,AMPK_A2B1G1
+"AMPK (alpha 2, beta 1, gamma 2)",FPLX,000039,AMPK_A2B1G2
+"AMPK (alpha 2, beta 1, gamma 3)",FPLX,000040,AMPK_A2B1G3
+"AMPK (alpha 2, beta 2, gamma 1)",FPLX,000041,AMPK_A2B2G1
+"AMPK (alpha 2, beta 2, gamma 2)",FPLX,000042,AMPK_A2B2G2
+"AMPK (alpha 2, beta 2, gamma 3)",FPLX,000043,AMPK_A2B2G3
+"AMPK (α 1, β 1, γ 1)",FPLX,000032,AMPK_A1B1G1
+"AMPK (α 1, β 1, γ 2)",FPLX,000033,AMPK_A1B1G2
+"AMPK (α 1, β 1, γ 3)",FPLX,000034,AMPK_A1B1G3
+"AMPK (α 1, β 2, γ 1)",FPLX,000035,AMPK_A1B2G1
+"AMPK (α 1, β 2, γ 2)",FPLX,000036,AMPK_A1B2G2
+"AMPK (α 1, β 2, γ 3)",FPLX,000037,AMPK_A1B2G3
+"AMPK (α 2, β 1, γ 1)",FPLX,000038,AMPK_A2B1G1
+"AMPK (α 2, β 1, γ 2)",FPLX,000039,AMPK_A2B1G2
+"AMPK (α 2, β 1, γ 3)",FPLX,000040,AMPK_A2B1G3
+"AMPK (α 2, β 2, γ 1)",FPLX,000041,AMPK_A2B2G1
+"AMPK (α 2, β 2, γ 2)",FPLX,000042,AMPK_A2B2G2
+"AMPK (α 2, β 2, γ 3)",FPLX,000043,AMPK_A2B2G3
+"Glutamate receptors, ionotropic, kainate",FPLX,000269,Kainate_family
+"Na(+),K(+)-ATPase",FPLX,000303,Na_K_ATPase
+"Na,K-ATPase beta subunit",FPLX,000058,ATP1B
+"Na,K-ATPase β subunit",FPLX,000058,ATP1B
+"Na,K-ATPase",FPLX,000303,Na_K_ATPase
+(9-1-1) complex,FPLX,000001,9_1_1
+14-3-3 proteins,FPLX,000323,p14_3_3
+14-3-3,FPLX,000323,p14_3_3
+14-3-3zeta,UP,P63104,1433Z_HUMAN
+4E-BP1,UP,Q13541,4EBP1_HUMAN
+4EBP,FPLX,000154,EIF4EBP
+4EBP1,UP,Q13541,4EBP1_HUMAN
+53BP1,UP,Q12888,TP53B_HUMAN
+9-1-1 complex,FPLX,000001,9_1_1
+9-1-1,FPLX,000001,9_1_1
+a-adrenoreceptor,FPLX,000019,ADRA
+a-cathenin,FPLX,000126,CTNNA
+A2t,FPLX,000047,Annexin_II_heterotetramer
+ABA,PUBCHEM,5280896,
+ABA,CHEBI,CHEBI:2365,(+)-abscisic acid
+Abeta,UP,P05067,A4_HUMAN
+Abeta,CHEBI,CHEBI:64645,amyloid-beta
+Abi1,UP,Q8IZP0,ABI1_HUMAN
+ABL family,FPLX,000003,ABL_family
+ABL,FPLX,000003,ABL_family
+Abl,UP,P00519,ABL1_HUMAN
+AC,MESH,D000230,Adenocarcinoma
+AC,UP,Q08828,ADCY1_HUMAN
+ACAD,FPLX,000004,ACAD
+ACC,FPLX,000005,ACC
+ACCs,FPLX,000005,ACC
+Acetate-CoA ligase,FPLX,000006,Acetyl_CoA_synthetase
+acetyl CoA ligase,FPLX,000006,Acetyl_CoA_synthetase
+acetyl CoA synthase,FPLX,000006,Acetyl_CoA_synthetase
+Acetyl Coenzyme A Carboxylase,FPLX,000005,ACC
+Acetyl-CoA carboxylase,FPLX,000005,ACC
+acetyl-CoA carboxylase,FPLX,000005,ACC
+Acetyl-CoA synthetase,FPLX,000006,Acetyl_CoA_synthetase
+acetyl-CoA synthetase,FPLX,000006,Acetyl_CoA_synthetase
+acetyl-coenzyme A synthase,FPLX,000006,Acetyl_CoA_synthetase
+acetylcholine receptor,FPLX,000102,CHRM
+Ack1,UP,Q07912,ACK1_HUMAN
+ACS,FPLX,000006,Acetyl_CoA_synthetase
+Acsl,FPLX,000008,ACSL
+actin filament,FPLX,000009,Actin
+actin,FPLX,000009,Actin
+actinin,FPLX,000014,ACTN
+actins,FPLX,000009,Actin
+Activin A protein,FPLX,000011,Activin_A
+Activin A,FPLX,000011,Activin_A
+activin A,FPLX,000011,Activin_A
+activin AB,FPLX,000012,Activin_AB
+activin protein,FPLX,000010,Activin
+Activin,FPLX,000010,Activin
+activin,FPLX,000010,Activin
+activin-A,FPLX,000011,Activin_A
+activin-B,FPLX,000013,Activin_B
+activinA,FPLX,000011,Activin_A
+activins,FPLX,000010,Activin
+acyl CoA dehydrogenase,FPLX,000004,ACAD
+acyl-CoA dehydrogenase,FPLX,000004,ACAD
+Acyl-CoA Oxidase,FPLX,000007,ACOX
+acyl-CoA oxidases,FPLX,000007,ACOX
+Adaptor Protein 2 complex,FPLX,000015,Adaptor_protein_II
+adaptor protein complex 2,FPLX,000015,Adaptor_protein_II
+adaptor protein complex 3,FPLX,000016,Adaptor_protein_III
+adenylate cyclase,FPLX,000017,ADCY
+adenylyl cyclase,FPLX,000017,ADCY
+adhesion,GO,GO:0007155,cell adhesion
+adhesion,MESH,D002448,Cell Adhesion
+adiponectin,UP,Q15848,ADIPO_HUMAN
+ADP,CHEBI,CHEBI:16761,ADP
+ADP,PUBCHEM,6022,
+ADP ribosylation factor,FPLX,000053,ARF_GTPase_family
+afatinib,PUBCHEM,10184653,
+afatinib,LINCS,10133-101,
+afatinib,CHEBI,CHEBI:61390,afatinib
+AHR,UP,P35869,AHR_HUMAN
+AICAR,PUBCHEM,65110,
+AICAR,CHEBI,CHEBI:18406,AICA ribonucleotide
+AKT family,FPLX,000023,AKT
+AKT,FPLX,000023,AKT
+Akt,FPLX,000023,AKT
+AKT1,UP,P31749,AKT1_HUMAN
+Akt1,UP,P31749,AKT1_HUMAN
+AKT2,UP,P31751,AKT2_HUMAN
+Akt2,UP,P31751,AKT2_HUMAN
+alcohol dehydrogenase,FPLX,000018,ADH
+alcohol,PUBCHEM,702,
+alcohol,CHEBI,CHEBI:16236,ethanol
+alcohol,HMDB,HMDB00108,
+aldehyde dehydrogenase (NAD+),FPLX,000024,ALDH
+Aldehyde dehydrogenase,FPLX,000024,ALDH
+aldehyde dehydrogenase,FPLX,000024,ALDH
+ALDH,FPLX,000024,ALDH
+ALDO,FPLX,000025,ALDO
+aldosterone,CHEBI,CHEBI:27584,aldosterone
+aldosterone,PUBCHEM,5839,
+ALG10,FPLX,000026,ALG10
+ALIX,HGNC,8766,PDCD6IP
+ALIX,UP,Q8WUM4,PDC6I_HUMAN
+ALK,UP,Q9UM73,ALK_HUMAN
+alkali myosin light chains,FPLX,000297,MYL_alkali
+alpha adrenoceptor,FPLX,000019,ADRA
+alpha catenin,FPLX,000126,CTNNA
+alpha tubulin,FPLX,000483,TUBA
+alpha(2)-adrenoceptors,FPLX,000020,ADRA2
+alpha(2)-ARs,FPLX,000020,ADRA2
+alpha-adrenergic receptor,FPLX,000019,ADRA
+alpha-adrenoreceptor,FPLX,000019,ADRA
+alpha-adrenoreceptors,FPLX,000019,ADRA
+alpha-catenin,FPLX,000126,CTNNA
+alpha1 adrenoceptor,FPLX,000019,ADRA
+"Alpha-1,2-glucosyltransferase",FPLX,000026,ALG10
+"Alpha-1,2-glucosyltransferases",FPLX,000026,ALG10
+"alpha-1,2-glucosyltransferase",FPLX,000026,ALG10
+"alpha-1,2-glucosyltransferases",FPLX,000026,ALG10
+"Alpha-1,3-glucosyltransferase",FPLX,000029,ALG6_family
+"Alpha-1,3-glucosyltransferases",FPLX,000029,ALG6_family
+"alpha-1,3-glucosyltransferase",FPLX,000029,ALG6_family
+"alpha-1,3-glucosyltransferases",FPLX,000029,ALG6_family
+"Alpha-1,4-glucosyltransferase",FPLX,000029,ALG6_family
+"Alpha-1,4-glucosyltransferases",FPLX,000029,ALG6_family
+"alpha-1,4-glucosyltransferase",FPLX,000029,ALG6_family
+"alpha-1,4-glucosyltransferases",FPLX,000029,ALG6_family
+alpha1beta1gamma1,FPLX,000032,AMPK_A1B1G1
+alpha1beta1gamma2,FPLX,000033,AMPK_A1B1G2
+alpha1beta1gamma3,FPLX,000034,AMPK_A1B1G3
+alpha1beta2gamma1,FPLX,000035,AMPK_A1B2G1
+alpha1beta2gamma2,FPLX,000036,AMPK_A1B2G2
+alpha2 adrenoceptor,FPLX,000020,ADRA2
+alpha2-AR,FPLX,000020,ADRA2
+alpha2beta1 integrin,FPLX,000261,Integrins
+alpha2beta1gamma1,FPLX,000038,AMPK_A2B1G1
+alpha2beta2gamma1,FPLX,000041,AMPK_A2B2G1
+alpha2beta2gamma2,FPLX,000042,AMPK_A2B2G2
+alpha2beta2gamma3,FPLX,000043,AMPK_A2B2G3
+ALS,UP,P35858,ALS_HUMAN
+AM,HGNC,259,ADM
+AM,UP,P35318,ADML_HUMAN
+AM,MESH,D000650,Amnion
+AMG655,MESH,C554537,conatumumab
+AMLC,FPLX,000297,MYL_alkali
+AMP,HMDB,HMDB00045,
+AMP,CHEBI,CHEBI:16027,adenosine 5'-monophosphate
+AMP,PUBCHEM,6083,
+AMPA glutamate receptor,FPLX,000191,GRIA
+AMPA receptor,FPLX,000191,GRIA
+AMPA-R,FPLX,000191,GRIA
+AMPA-subtype ionotropic glutamate receptors,FPLX,000191,GRIA
+AMPAR,FPLX,000191,GRIA
+AMPARs,FPLX,000191,GRIA
+AMPK (A1/B1/G1),FPLX,000032,AMPK_A1B1G1
+AMPK (A1/B1/G2),FPLX,000033,AMPK_A1B1G2
+AMPK (A1/B1/G3),FPLX,000034,AMPK_A1B1G3
+AMPK (A1/B2/G1),FPLX,000035,AMPK_A1B2G1
+AMPK (A1/B2/G2),FPLX,000036,AMPK_A1B2G2
+AMPK (A1/B2/G3),FPLX,000037,AMPK_A1B2G3
+AMPK (A2/B1/G1),FPLX,000038,AMPK_A2B1G1
+AMPK (A2/B1/G2),FPLX,000039,AMPK_A2B1G2
+AMPK (A2/B1/G3),FPLX,000040,AMPK_A2B1G3
+AMPK (A2/B2/G1),FPLX,000041,AMPK_A2B2G1
+AMPK (A2/B2/G2),FPLX,000042,AMPK_A2B2G2
+AMPK (A2/B2/G3),FPLX,000043,AMPK_A2B2G3
+AMPK a1b1g1,FPLX,000032,AMPK_A1B1G1
+AMPK a1b1g2,FPLX,000033,AMPK_A1B1G2
+AMPK a1b1g3,FPLX,000034,AMPK_A1B1G3
+AMPK a1b2g1,FPLX,000035,AMPK_A1B2G1
+AMPK a1b2g2,FPLX,000036,AMPK_A1B2G2
+AMPK a2b1g1,FPLX,000038,AMPK_A2B1G1
+AMPK a2b2g1,FPLX,000041,AMPK_A2B2G1
+AMPK a2b2g2,FPLX,000042,AMPK_A2B2G2
+AMPK a2b2g3,FPLX,000043,AMPK_A2B2G3
+AMPK alpha1beta1gamma1,FPLX,000032,AMPK_A1B1G1
+AMPK alpha1beta1gamma2,FPLX,000033,AMPK_A1B1G2
+AMPK alpha1beta1gamma3,FPLX,000034,AMPK_A1B1G3
+AMPK alpha1beta2gamma1,FPLX,000035,AMPK_A1B2G1
+AMPK alpha1beta2gamma2,FPLX,000036,AMPK_A1B2G2
+AMPK alpha1beta2gamma3,FPLX,000037,AMPK_A1B2G3
+AMPK alpha2beta1gamma1,FPLX,000038,AMPK_A2B1G1
+AMPK alpha2beta1gamma2,FPLX,000039,AMPK_A2B1G2
+AMPK alpha2beta1gamma3,FPLX,000040,AMPK_A2B1G3
+AMPK alpha2beta2gamma1,FPLX,000041,AMPK_A2B2G1
+AMPK alpha2beta2gamma2,FPLX,000042,AMPK_A2B2G2
+AMPK alpha2beta2gamma3,FPLX,000043,AMPK_A2B2G3
+AMPK α1β1γ1,FPLX,000032,AMPK_A1B1G1
+AMPK α1β1γ2,FPLX,000033,AMPK_A1B1G2
+AMPK α1β1γ3,FPLX,000034,AMPK_A1B1G3
+AMPK α1β2γ1,FPLX,000035,AMPK_A1B2G1
+AMPK α1β2γ2,FPLX,000036,AMPK_A1B2G2
+AMPK α1β2γ3,FPLX,000037,AMPK_A1B2G3
+AMPK α2β1γ1,FPLX,000038,AMPK_A2B1G1
+AMPK α2β1γ2,FPLX,000039,AMPK_A2B1G2
+AMPK α2β1γ3,FPLX,000040,AMPK_A2B1G3
+AMPK α2β2γ1,FPLX,000041,AMPK_A2B2G1
+AMPK α2β2γ2,FPLX,000042,AMPK_A2B2G2
+AMPK α2β2γ3,FPLX,000043,AMPK_A2B2G3
+AMPK,FPLX,000031,AMPK
+AMPK-alpha1,UP,Q13131,AAPK1_HUMAN
+AMPK-alpha2,UP,P54646,AAPK2_HUMAN
+AMPK-α1,UP,Q13131,AAPK1_HUMAN
+AMPK-α2,UP,P54646,AAPK2_HUMAN
+AMPKalpha,FPLX,000044,AMPK_alpha
+AMPKalpha1 catalytic domain,UP,Q13131,AAPK1_HUMAN
+AMPKalpha1,UP,Q13131,AAPK1_HUMAN
+AMPKα,FPLX,000044,AMPK_alpha
+AMPKα1 catalytic domain,UP,Q13131,AAPK1_HUMAN
+AMPKα1,UP,Q13131,AAPK1_HUMAN
+amyloid beta,UP,P05067,A4_HUMAN
+amyloid beta,CHEBI,CHEBI:64645,amyloid-beta
+amyloid β,UP,P05067,A4_HUMAN
+amyloid β,CHEBI,CHEBI:64645,amyloid-beta
+Ang II,UP,P01019,ANGT_HUMAN
+AngII,UP,P01019,ANGT_HUMAN
+angiogenesis,GO,GO:0001525,angiogenesis
+angiogenesis,MESH,D018919,"Neovascularization, Physiologic"
+annexin A2 heterotetramer,FPLX,000047,Annexin_II_heterotetramer
+annexin II heterotetramer,FPLX,000047,Annexin_II_heterotetramer
+ANXA2 heterotetramer,FPLX,000047,Annexin_II_heterotetramer
+AP-1,FPLX,000048,AP1
+AP-2 adaptor complex,FPLX,000015,Adaptor_protein_II
+AP-2 complex,FPLX,000015,Adaptor_protein_II
+AP-2 transcription factor,FPLX,000463,TFAP2
+AP-2,FPLX,000015,Adaptor_protein_II
+AP-3,FPLX,000016,Adaptor_protein_III
+AP1,FPLX,000048,AP1
+AP2 adaptor complex,FPLX,000015,Adaptor_protein_II
+AP2 clathrin adaptor complex,FPLX,000015,Adaptor_protein_II
+AP2 complex,FPLX,000015,Adaptor_protein_II
+AP2,FPLX,000015,Adaptor_protein_II
+AP3,FPLX,000016,Adaptor_protein_III
+Apaf-1,UP,O14727,APAF_HUMAN
+APC,UP,P25054,APC_HUMAN
+APC/C,FPLX,000050,APC_C
+apigenin,CHEBI,CHEBI:18388,apigenin
+apigenin,PUBCHEM,5280443,
+ApoA,FPLX,000051,APOA
+apoA,FPLX,000051,APOA
+apocynin,CHEBI,CHEBI:2781,apocynin
+apocynin,PUBCHEM,2214,
+apolipoprotein (a),FPLX,000051,APOA
+apolipoprotein A,FPLX,000051,APOA
+apolipoprotein(A),FPLX,000051,APOA
+apolipoprotein(a),FPLX,000051,APOA
+Apolipoprotein,FPLX,000052,Apolipoprotein
+apolipoprotein,FPLX,000052,Apolipoprotein
+apolipoproteins,FPLX,000052,Apolipoprotein
+Apoptosis,GO,GO:0006915,apoptotic process
+Apoptosis,MESH,D017209,Apoptosis
+apoptosis,GO,GO:0006915,apoptotic process
+apoptosis,MESH,D017209,Apoptosis
+AR,UP,P10275,ANDR_HUMAN
+ARF,FPLX,000053,ARF_GTPase_family
+ARF,UP,Q8N726,ARF_HUMAN
+Arf,UP,Q8N726,ARF_HUMAN
+Arp2/3,FPLX,000054,Arp2_3_protein
+Arsenic trioxide,CHEBI,CHEBI:30621,diarsenic trioxide
+Arsenic trioxide,PUBCHEM,518605,
+arsenic,PUBCHEM,5359596,
+arsenic,CHEBI,CHEBI:27563,arsenic atom
+arsenite,CHEBI,CHEBI:29866,arsenite(3-)
+arsenite,PUBCHEM,544,
+artemisinin,CHEBI,CHEBI:223316,(+)-artemisinin
+artemisinin,PUBCHEM,68827,
+ASK1,UP,Q99683,M3K5_HUMAN
+aspirin,PUBCHEM,2244,
+aspirin,CHEBI,CHEBI:15365,acetylsalicylic acid
+ASPP1,UP,Q96KQ4,ASPP1_HUMAN
+ASPP2,UP,Q13625,ASPP2_HUMAN
+ATF2,UP,P15336,ATF2_HUMAN
+ATG4,FPLX,000056,ATG4
+Atg4,FPLX,000056,ATG4
+ATM,UP,Q13315,ATM_HUMAN
+ATP synthase H + transporting mitochondrial F0 complex subunit G,FPLX,000059,ATP5G
+ATP synthase,FPLX,000060,ATP_synthase
+ATP,HMDB,HMDB00538,
+ATP,PUBCHEM,5957,
+ATP,CHEBI,CHEBI:15422,ATP
+ATP1A,FPLX,000057,ATP1A
+ATP1B,FPLX,000058,ATP1B
+ATPase Na+/K+ transporting subunit alpha,FPLX,000057,ATP1A
+ATPase Na+/K+ transporting subunit beta,FPLX,000057,ATP1A
+ATPase Na+/K+ transporting subunit α,FPLX,000057,ATP1A
+ATPase Na+/K+ transporting subunit β,FPLX,000057,ATP1A
+ATR,UP,Q13535,ATR_HUMAN
+ATRA,CHEBI,CHEBI:15367,all-trans-retinoic acid
+ATRA,PUBCHEM,444795,
+autophagic cell death,GO,GO:0048102,autophagic cell death
+Autophagy,GO,GO:0006914,autophagy
+Autophagy,MESH,D001343,Autophagy
+autophagy,GO,GO:0006914,autophagy
+autophagy,MESH,D001343,Autophagy
+Axin,FPLX,000062,AXIN
+AZD6244,CHEBI,CHEBI:90227,selumetinib
+AZD6244,PUBCHEM,10127622,
+Aβ,UP,P05067,A4_HUMAN
+Aβ,CHEBI,CHEBI:64645,amyloid-beta
+B3GAT,FPLX,000063,B3GAT
+b-adrenergic receptor,FPLX,000021,ADRB
+b-arrestin,FPLX,000055,ARRB
+B-Raf,UP,P15056,BRAF_HUMAN
+b-receptors,FPLX,000021,ADRB
+B1,UP,O43157,PLXB1_HUMAN
+B1,UP,P14635,CCNB1_HUMAN
+BAD,UP,Q92934,BAD_HUMAN
+Bad,UP,Q92934,BAD_HUMAN
+Bak,UP,Q16611,BAK_HUMAN
+Bam32,UP,Q9UN19,DAPP1_HUMAN
+BARK,FPLX,000022,ADRBK
+barrestins,FPLX,000055,ARRB
+BAX,UP,Q07812,BAX_HUMAN
+Bax,UP,Q07812,BAX_HUMAN
+BCKDC,FPLX,000064,BCKDC
+BCKDH,FPLX,000064,BCKDC
+BCL-2,UP,P10415,BCL2_HUMAN
+Bcl-2,UP,P10415,BCL2_HUMAN
+bcl-2,UP,P10415,BCL2_HUMAN
+Bcl-3,HGNC,998,BCL3
+Bcl-xL,UP,Q07817,B2CL1_HUMAN
+BCL2,UP,P10415,BCL2_HUMAN
+Bcl2,UP,P10415,BCL2_HUMAN
+BCR,UP,P11274,BCR_HUMAN
+Beclin-1,UP,Q14457,BECN1_HUMAN
+berberine,CHEBI,CHEBI:16118,berberine
+berberine,PUBCHEM,2353,
+"Beta-1,3-glucuronyltransferase",FPLX,000063,B3GAT
+"Beta-1,3-glucuronyltransferases",FPLX,000063,B3GAT
+"beta-1,3-glucuronyltransferase",FPLX,000063,B3GAT
+"beta-1,3-glucuronyltransferases",FPLX,000063,B3GAT
+Beta 3-glycosyltransferase,FPLX,000065,Beta_3_4_GTF
+Beta 3-glycosyltransferases,FPLX,000065,Beta_3_4_GTF
+beta 3-glycosyltransferase,FPLX,000065,Beta_3_4_GTF
+beta 3-glycosyltransferases,FPLX,000065,Beta_3_4_GTF
+Beta 4-glycosyltransferase,FPLX,000065,Beta_3_4_GTF
+Beta 4-glycosyltransferases,FPLX,000065,Beta_3_4_GTF
+beta 4-glycosyltransferase,FPLX,000065,Beta_3_4_GTF
+beta 4-glycosyltransferases,FPLX,000065,Beta_3_4_GTF
+beta adrenergic receptor kinase,FPLX,000022,ADRBK
+beta interferons,FPLX,000247,IFNB
+Beta Tubulin,FPLX,000484,TUBB
+Beta tubulin,FPLX,000484,TUBB
+beta Tubulin,FPLX,000484,TUBB
+beta tubulin,FPLX,000484,TUBB
+beta-adrenergic receptor,FPLX,000021,ADRB
+beta-adrenoreceptor,FPLX,000021,ADRB
+beta-catenin,UP,P35222,CTNB1_HUMAN
+beta-TrCP,UP,Q9Y297,FBW1A_HUMAN
+Beta-Tubulin,FPLX,000484,TUBB
+Beta-tubulin,FPLX,000484,TUBB
+beta-Tubulin,FPLX,000484,TUBB
+beta-tubulin,FPLX,000484,TUBB
+betaAR,FPLX,000021,ADRB
+betaARK,FPLX,000022,ADRBK
+BEZ235,PUBCHEM,11977753,
+BEZ235,CHEBI,CHEBI:71952,dactolisib
+bFGF,UP,P09038,FGF2_HUMAN
+Bid,UP,P55957,BID_HUMAN
+BIM,UP,O43521,B2L11_HUMAN
+Bim,UP,O43521,B2L11_HUMAN
+biosynthesis,GO,GO:0009058,biosynthetic process
+BIRs,FPLX,000066,BIRC
+BITC,PUBCHEM,2346,
+BITC,CHEBI,CHEBI:17484,benzyl isothiocyanate
+BMF,UP,Q96LC9,BMF_HUMAN
+BMI1,UP,P35226,BMI1_HUMAN
+BMP Receptor Type I,FPLX,000069,BMP_receptor_type_I
+BMP Receptor Type II,FPLX,000070,BMP_receptor_type_II
+BMP type I receptor,FPLX,000069,BMP_receptor_type_I
+BMP type II receptor,FPLX,000070,BMP_receptor_type_II
+BMP,FPLX,000067,BMP
+BMP9,UP,Q9UK05,GDF2_HUMAN
+bone morphogenetic protein I receptor,FPLX,000069,BMP_receptor_type_I
+bone morphogenetic protein receptor 1,FPLX,000069,BMP_receptor_type_I
+bone morphogenetic protein receptor 2,FPLX,000070,BMP_receptor_type_II
+bone morphogenetic protein receptor type I,FPLX,000069,BMP_receptor_type_I
+bone morphogenetic protein receptor type II,FPLX,000070,BMP_receptor_type_II
+bone morphogenetic protein type I receptors,FPLX,000069,BMP_receptor_type_I
+bone morphogenetic protein type II receptors,FPLX,000070,BMP_receptor_type_II
+bortezomib,CHEBI,CHEBI:52717,bortezomib
+bortezomib,PUBCHEM,387447,
+BPA,CHEBI,CHEBI:33216,bisphenol A
+BPA,PUBCHEM,6623,
+BRAF,UP,P15056,BRAF_HUMAN
+branched-chain alpha-keto acid dehydrogenase complex,FPLX,000064,BCKDC
+branched-chain alpha-ketoacid dehydrogenase complex,FPLX,000064,BCKDC
+branched-chain α-keto acid dehydrogenase complex,FPLX,000064,BCKDC
+branched-chain α-ketoacid dehydrogenase complex,FPLX,000064,BCKDC
+BRCA,FPLX,000071,BRCA
+BRCA1,UP,P38398,BRCA1_HUMAN
+BRCA2,UP,P51587,BRCA2_HUMAN
+BRI,FPLX,000069,BMP_receptor_type_I
+BRII,FPLX,000070,BMP_receptor_type_II
+BRSK1,UP,Q8TDC3,BRSK1_HUMAN
+BRSK2,UP,Q8IWQ3,BRSK2_HUMAN
+Bub1,UP,O43683,BUB1_HUMAN
+BubR1,UP,O60566,BUB1B_HUMAN
+butein,CHEBI,CHEBI:3237,butein
+butein,PUBCHEM,5281222,
+c-Abl Kinase,UP,P00519,ABL1_HUMAN
+c-Abl,UP,P00519,ABL1_HUMAN
+c-Cbl protein,UP,P22681,CBL_HUMAN
+c-Cbl,UP,P22681,CBL_HUMAN
+c-FLIP,UP,O15519,CFLAR_HUMAN
+c-Fos,UP,P01100,FOS_HUMAN
+c-fos,UP,P01100,FOS_HUMAN
+c-JNK,FPLX,000267,JNK
+c-Jun N-terminal kinase,FPLX,000267,JNK
+c-Jun NH2-terminal kinase,FPLX,000267,JNK
+c-Jun,UP,P05412,JUN_HUMAN
+c-jun,UP,P05412,JUN_HUMAN
+C-MAF,UP,O75444,MAF_HUMAN
+c-MAF,UP,O75444,MAF_HUMAN
+c-Maf,UP,O75444,MAF_HUMAN
+c-maf,UP,O75444,MAF_HUMAN
+c-MET,HGNC,7029,MET
+c-met,HGNC,7029,MET
+c-Met,UP,P08581,MET_HUMAN
+c-Myb,UP,P10242,MYB_HUMAN
+c-myc oncogene,UP,P01106,MYC_HUMAN
+c-myc proteins,UP,P01106,MYC_HUMAN
+c-MYC,UP,P01106,MYC_HUMAN
+c-Myc,UP,P01106,MYC_HUMAN
+c-myc,UP,P01106,MYC_HUMAN
+C-PARP,UP,P09874,PARP1_HUMAN
+c-Raf,UP,P04049,RAF1_HUMAN
+c-Rel,HGNC,9954,REL
+c-src,HGNC,11283,SRC
+c-Src,UP,P12931,SRC_HUMAN
+C/EBP,FPLX,000097,CEBP
+C/EBPalpha,UP,P49715,CEBPA_HUMAN
+C/EBPbeta,UP,P17676,CEBPB_HUMAN
+C/EBPβ,UP,P17676,CEBPB_HUMAN
+C/EBPα,UP,P49715,CEBPA_HUMAN
+c1 complex,FPLX,000072,C1
+C1,FPLX,000072,C1
+C1-complex,FPLX,000072,C1
+C1q,FPLX,000073,C1q
+Ca(2+)-calmodulin-dependent protein kinase II,FPLX,000077,CAMK2_complex
+Ca(2+)/calmodulin-dependent kinase II,FPLX,000077,CAMK2_complex
+Ca,HMDB,HMDB00464,
+Ca,CHEBI,CHEBI:29108,calcium(2+)
+Ca,PUBCHEM,271,
+cadherin,FPLX,000074,Cadherin
+caffeine,PUBCHEM,2519,
+caffeine,CHEBI,CHEBI:27732,caffeine
+Calcineurin catalytic subunit,FPLX,000384,PPP3C
+Calcineurin regulatory subunit,FPLX,000385,PPP3R
+calcineurin,FPLX,000383,PPP3
+calcium,HMDB,HMDB00464,
+calcium,CHEBI,CHEBI:29108,calcium(2+)
+calcium,PUBCHEM,271,
+Calmodulin,FPLX,000075,CALM
+calmodulin,FPLX,000075,CALM
+calmodulindependent kinase II,FPLX,000078,CAMK2_family
+calpain,FPLX,000079,CAPN
+CaM kinase II,FPLX,000077,CAMK2_complex
+CaM,FPLX,000075,CALM
+CaMK family,FPLX,000076,CAMK
+CaMK II,FPLX,000077,CAMK2_complex
+CaMK,FPLX,000076,CAMK
+CAMK2,FPLX,000078,CAMK2_family
+CaMK2,FPLX,000078,CAMK2_family
+CaMKII,FPLX,000077,CAMK2_complex
+CAMKII,FPLX,000078,CAMK2_family
+cAMP,PUBCHEM,6076,
+cAMP,CHEBI,CHEBI:17489,"3',5'-cyclic AMP"
+cAMP,HMDB,HMDB00058,
+cAMP-dependent PK,FPLX,000363,PKA
+cAMP-dependent protein kinase,FPLX,000363,PKA
+CaN,FPLX,000383,PPP3
+CAP23,UP,P80723,BASP1_HUMAN
+CAPE,PUBCHEM,5281787,
+CAPE,CHEBI,CHEBI:8062,phenethyl caffeate
+capsaicin,PUBCHEM,1548943,
+capsaicin,CHEBI,CHEBI:3374,capsaicin
+carboxylesterase,FPLX,000080,Carboxylesterase
+carboxylesterases,FPLX,000080,Carboxylesterase
+CARP-1,UP,Q8IX12,CCAR1_HUMAN
+Cas,UP,P56945,BCAR1_HUMAN
+Casein kinase 1,FPLX,000124,CSNK1
+casein kinase 1,FPLX,000124,CSNK1
+casein kinase 2,FPLX,000104,CK2
+casein kinase I,FPLX,000124,CSNK1
+casein kinase II complex,FPLX,000104,CK2
+casein kinase II,FPLX,000104,CK2
+caspase 3,UP,P42574,CASP3_HUMAN
+caspase 8,UP,Q14790,CASP8_HUMAN
+caspase,FPLX,000081,Caspase
+caspase-1,UP,P29466,CASP1_HUMAN
+Caspase-3,UP,P42574,CASP3_HUMAN
+caspase-3,UP,P42574,CASP3_HUMAN
+caspase-3/7,FPLX,000082,Caspase_3_7
+caspase-8,UP,Q14790,CASP8_HUMAN
+caspase-9,UP,P55211,CASP9_HUMAN
+caspases,FPLX,000081,Caspase
+catalase,UP,P04040,CATA_HUMAN
+catalytic subunit of calcineurin,FPLX,000384,PPP3C
+catenin alpha,FPLX,000126,CTNNA
+catenin α,FPLX,000126,CTNNA
+Caveolin,FPLX,000083,CAV
+caveolin,FPLX,000083,CAV
+caveolin-1,UP,Q03135,CAV1_HUMAN
+CBF3 complex,FPLX,000084,CBF3
+CBF3,FPLX,000084,CBF3
+Cbl,UP,P22681,CBL_HUMAN
+Cbl-b,UP,Q13191,CBLB_HUMAN
+CBP,UP,Q92793,CBP_HUMAN
+Cby,UP,Q9Y3M2,CBY1_HUMAN
+CCAAT/enhancer binding protein,FPLX,000097,CEBP
+CCN2,UP,P29279,CTGF_HUMAN
+CCND1,UP,P24385,CCND1_HUMAN
+CCT complex,FPLX,000085,CCT_complex
+CCT,FPLX,000085,CCT_complex
+Cd,PUBCHEM,23973,
+Cd,CHEBI,CHEBI:22977,cadmium atom
+CD16,FPLX,000086,CD16
+CD24,UP,P25063,CD24_HUMAN
+CD28,UP,P10747,CD28_HUMAN
+CD3,FPLX,000087,CD3
+CD32,FPLX,000088,CD32
+CD4,UP,P01730,CD4_HUMAN
+CD44,UP,P16070,CD44_HUMAN
+CD64,FPLX,000089,CD64
+CD8,FPLX,000090,CD8
+CD95,UP,P25445,TNR6_HUMAN
+Cdc20,UP,Q12834,CDC20_HUMAN
+CDC25 family,FPLX,000091,CDC25
+Cdc25 phosphatases,FPLX,000091,CDC25
+CDC25,FPLX,000091,CDC25
+Cdc25,FPLX,000091,CDC25
+CDC42,UP,P60953,CDC42_HUMAN
+Cdc42,UP,P60953,CDC42_HUMAN
+Cdc6,UP,Q99741,CDC6_HUMAN
+CDDP,CHEBI,CHEBI:27899,cisplatin
+CDDP,PUBCHEM,441203,
+CDK,FPLX,000092,CDK
+Cdk,FPLX,000092,CDK
+CDK1,UP,P06493,CDK1_HUMAN
+Cdk1,UP,P06493,CDK1_HUMAN
+CDK2,UP,P24941,CDK2_HUMAN
+Cdk2,UP,P24941,CDK2_HUMAN
+cdk2,UP,P24941,CDK2_HUMAN
+CDK4,UP,P11802,CDK4_HUMAN
+Cdk4,UP,P11802,CDK4_HUMAN
+CDK6,UP,Q00534,CDK6_HUMAN
+CDK8,UP,P49336,CDK8_HUMAN
+CDK9,UP,P50750,CDK9_HUMAN
+CDKN,FPLX,000094,CDKN
+CDKN1,FPLX,000095,CDKN1
+CDKN1A,UP,P38936,CDN1A_HUMAN
+CDKN2,FPLX,000096,CDKN2
+CDKs,FPLX,000092,CDK
+celecoxib,PUBCHEM,2662,
+celecoxib,CHEBI,CHEBI:41423,celecoxib
+cell adhesion,GO,GO:0007155,cell adhesion
+cell adhesion,MESH,D002448,Cell Adhesion
+cell cycle,GO,GO:0007049,cell cycle
+cell cycle,MESH,D002453,Cell Cycle
+cell death,GO,GO:0008219,cell death
+cell death,MESH,D016923,Cell Death
+cell growth,GO,GO:0016049,cell growth
+cell growth,MESH,D048708,Cell Growth Processes
+cell migration,GO,GO:0016477,cell migration
+cell migration,MESH,D002465,Cell Movement
+cell migration,NCIT,C26169,
+cell motility,GO,GO:0016477,cell migration
+cell motility,MESH,D002465,Cell Movement
+cell motility,NCIT,C16404,
+cell motility,GO,GO:0048870,cell motility
+cell proliferation,GO,GO:0008283,cell population proliferation
+cell proliferation,MESH,D049109,Cell Proliferation
+cell survival,MESH,D002470,Cell Survival
+cell viability,MESH,D002470,Cell Survival
+cellular senescence,GO,GO:0090398,cellular senescence
+cellular senescence,MESH,D016922,Cellular Senescence
+ceramide,CHEBI,CHEBI:17761,ceramide
+cetuximab,CHEMBL,1201577,
+CFM-4,PUBCHEM,2871439,
+chaperonin containing TCP-1,FPLX,000085,CCT_complex
+chaperonin,FPLX,000085,CCT_complex
+chaperonin-containing t-complex polypeptide 1,FPLX,000085,CCT_complex
+chaperonin-containing TCP1 complex,FPLX,000085,CCT_complex
+checkpoint kinase,FPLX,000098,CHEK
+chemoattractant receptor,FPLX,000100,Chemokine_receptor
+chemokine,FPLX,000099,Chemokine
+chemokines,FPLX,000099,Chemokine
+CHIP,UP,Q9UNE7,CHIP_HUMAN
+CHK1,UP,O14757,CHK1_HUMAN
+Chk1,UP,O14757,CHK1_HUMAN
+CHK2,UP,O96017,CHK2_HUMAN
+Chk2,UP,O96017,CHK2_HUMAN
+cholesterol,CHEBI,CHEBI:16113,cholesterol
+cholesterol,PUBCHEM,5997,
+choline esterase,FPLX,000101,Cholinesterase
+cholinesterase,FPLX,000101,Cholinesterase
+CHOP,UP,P35638,DDIT3_HUMAN
+CIP1,UP,P38936,CDN1A_HUMAN
+CIP2A,UP,Q8TCG1,CIP2A_HUMAN
+Cisplatin,CHEBI,CHEBI:27899,cisplatin
+Cisplatin,PUBCHEM,441203,
+cisplatin,CHEBI,CHEBI:27899,cisplatin
+cisplatin,PUBCHEM,441203,
+CK2,FPLX,000104,CK2
+CKI,FPLX,000094,CDKN
+Clade B serpin,FPLX,000431,SERPINB
+clade B serpins,FPLX,000431,SERPINB
+Class 1 NF-kappaBs,FPLX,000312,NFkappaB_1
+class 1 NF-kappaBs,FPLX,000312,NFkappaB_1
+Class 1 NF-κBs,FPLX,000312,NFkappaB_1
+class 1 NF-κBs,FPLX,000312,NFkappaB_1
+Class 2 NF-kappaBs,FPLX,000313,NFkappaB_2
+class 2 NF-kappaBs,FPLX,000313,NFkappaB_2
+Class 2 NF-κBs,FPLX,000313,NFkappaB_2
+class 2 NF-κBs,FPLX,000313,NFkappaB_2
+Class C GPCR,FPLX,000187,GPCR
+Class I HDACs,FPLX,000221,HDAC_I
+class I HDACs,FPLX,000221,HDAC_I
+class I histone deacetylases,FPLX,000221,HDAC_I
+Class I NF-kappaBs,FPLX,000312,NFkappaB_1
+class I NF-kappaBs,FPLX,000312,NFkappaB_1
+Class I NF-κBs,FPLX,000312,NFkappaB_1
+class I NF-κBs,FPLX,000312,NFkappaB_1
+class II HDACs,FPLX,000222,HDAC_II
+class II histone deacetylases,FPLX,000222,HDAC_II
+Class II NF-kappaBs,FPLX,000313,NFkappaB_2
+class II NF-kappaBs,FPLX,000313,NFkappaB_2
+Class II NF-κBs,FPLX,000313,NFkappaB_2
+class II NF-κBs,FPLX,000313,NFkappaB_2
+Class III HDACs,FPLX,000223,HDAC_III
+class III HDACs,FPLX,000223,HDAC_III
+class III histone deacetylases,FPLX,000223,HDAC_III
+Class IV HDACs,FPLX,000224,HDAC_IV
+class IV HDACs,FPLX,000224,HDAC_IV
+class IV histone deacetylases,FPLX,000224,HDAC_IV
+clathrin coat,FPLX,000105,Clathrin
+clathrin,FPLX,000105,Clathrin
+cleaved PARP,UP,P09874,PARP1_HUMAN
+cMet receptor,UP,P08581,MET_HUMAN
+CNKSR,FPLX,000106,CNKSR
+CO 2,CHEBI,CHEBI:16526,carbon dioxide
+CO 2,PUBCHEM,280,
+CO,CHEBI,CHEBI:17245,carbon monoxide
+CO,PUBCHEM,281,
+cocaine,PUBCHEM,446220,
+cocaine,CHEBI,CHEBI:27958,cocaine
+cofilin,FPLX,000107,Cofilin
+cohesin complex,FPLX,000108,Cohesin
+cohesin,FPLX,000108,Cohesin
+Col4,FPLX,000110,COL4
+COLGALT,FPLX,000112,COLGALT
+ColIV,FPLX,000110,COL4
+Collagen beta(1-O)galactosyltransferase,FPLX,000112,COLGALT
+Collagen beta(1-O)galactosyltransferases,FPLX,000112,COLGALT
+collagen beta(1-O)galactosyltransferase,FPLX,000112,COLGALT
+collagen beta(1-O)galactosyltransferases,FPLX,000112,COLGALT
+collagen IV,FPLX,000110,COL4
+collagen type I,FPLX,000109,COL1
+Collagen Type IV,FPLX,000110,COL4
+collagen type IV,FPLX,000110,COL4
+collagen type V,FPLX,000111,COL5
+collagen,MESH,D003094,Collagen
+collagen,CHEBI,CHEBI:3815,Collagen
+complex II,FPLX,000502,ETC_complex_II
+complex III,FPLX,000503,ETC_complex_III
+Complex IV,FPLX,000113,COX
+connector enhancer of kinase suppressor of ras,FPLX,000106,CNKSR
+copper,CHEBI,CHEBI:29036,copper(2+)
+copper,PUBCHEM,27099,
+cortactin,IP,IPR015503,
+cortactin,UP,Q14247,SRC8_HUMAN
+COX-2,UP,P35354,PGH2_HUMAN
+Cox4,FPLX,000114,COX4
+COX6A,FPLX,000115,COX6A
+Cox6a,FPLX,000115,COX6A
+Cox6b,FPLX,000116,COX6B
+COX7A,FPLX,000117,COX7A
+Cox7a,FPLX,000117,COX7A
+Cox7b,FPLX,000118,COX7B
+Cox8,FPLX,000119,COX8
+cPARP,UP,P09874,PARP1_HUMAN
+cPLA2,FPLX,000366,PLA2
+CRAF,UP,P04049,RAF1_HUMAN
+CREB family,FPLX,000120,CREB
+CREB,FPLX,000120,CREB
+CRISP,FPLX,000121,CRISP
+CRISPs,FPLX,000121,CRISP
+Crk,UP,P46108,CRK_HUMAN
+CRSP complex,FPLX,000122,CRSP
+CRSP,FPLX,000122,CRSP
+CRSP/Med complex,FPLX,000122,CRSP
+CsA,PUBCHEM,5284373,
+CsA,CHEBI,CHEBI:4031,cyclosporin A
+CSC,MESH,D014411,Neoplastic Stem Cells
+CSF-1R,UP,P07333,CSF1R_HUMAN
+CSNK1,FPLX,000124,CSNK1
+CSNK2,FPLX,000125,CSNK2
+CtIP,UP,Q99708,CTIP_HUMAN
+cTnC,FPLX,000478,Troponin_C
+cTnI,FPLX,000478,Troponin_C
+cTnT,FPLX,000480,Troponin_T
+cullin proteins,FPLX,000127,CUL
+cullin,FPLX,000127,CUL
+cullins,FPLX,000127,CUL
+Curcumin,CHEBI,CHEBI:3962,curcumin
+Curcumin,PUBCHEM,969516,
+curcumin,CHEBI,CHEBI:3962,curcumin
+curcumin,PUBCHEM,969516,
+CXCL12,UP,P48061,SDF1_HUMAN
+CXCL8,UP,P10145,IL8_HUMAN
+CXCR2,UP,P25025,CXCR2_HUMAN
+CXCR4,UP,P61073,CXCR4_HUMAN
+cyclic AMP-dependent protein kinase,FPLX,000363,PKA
+cyclic-AMP-dependent protein kinase,FPLX,000363,PKA
+Cyclin A,FPLX,000131,Cyclin_A
+cyclin A,FPLX,000131,Cyclin_A
+Cyclin D,FPLX,000132,Cyclin_D
+Cyclin D2,UP,P30279,CCND2_HUMAN
+cyclin D2,UP,P30279,CCND2_HUMAN
+cyclin dependent kinase inhibitors,FPLX,000094,CDKN
+cyclin E,FPLX,000133,Cyclin_E
+cyclin family,FPLX,000130,Cyclin
+Cyclin,FPLX,000130,Cyclin
+cyclin,FPLX,000130,Cyclin
+Cyclin-A,FPLX,000131,Cyclin_A
+cyclin-dependent kinase inhibitor,FPLX,000094,CDKN
+cyclin-dependent protein kinase inhibitors,FPLX,000094,CDKN
+cyclins,FPLX,000130,Cyclin
+cyclophilin,FPLX,000134,Cyclophilin
+cyclophilins,FPLX,000134,Cyclophilin
+CYLD,UP,Q9NQC7,CYLD_HUMAN
+cypermethrin,CHEBI,CHEBI:4042,cypermethrin
+cypermethrin,PUBCHEM,2912,
+cysteine rich secretory proteins,FPLX,000121,CRISP
+cysteine-rich secretory proteins,FPLX,000121,CRISP
+cytochrome bc1 complex,FPLX,000503,ETC_complex_III
+Cytochrome c oxidase subunit 6a,FPLX,000115,COX6A
+cytochrome c oxidase subunit VIII,FPLX,000119,COX8
+cytochrome c oxidase,FPLX,000113,COX
+cytochrome C,UP,P99999,CYC_HUMAN
+cytochrome c,UP,P99999,CYC_HUMAN
+cytokine production,GO,GO:0001816,cytokine production
+cytoplasmic dynein,FPLX,000135,Cytoplasmic_dynein
+cytosolic phospholipase A(2),FPLX,000366,PLA2
+cytosolic phospholipase A2,FPLX,000366,PLA2
+cytosolic PLA2,FPLX,000366,PLA2
+DA,PUBCHEM,681,
+DA,CHEBI,CHEBI:18243,dopamine
+dabrafenib,PUBCHEM,44462760,
+dabrafenib,CHEBI,CHEBI:75045,dabrafenib
+DAG kinase,FPLX,000140,DGK
+DAG,PUBCHEM,6026790,
+DAG,CHEBI,CHEBI:85682,diacylglycerol 30:1
+damage,MESH,D004249,DNA Damage
+Danusertib,PUBCHEM,11442891,
+Danusertib,CHEMBL,CHEMBL402548,
+Danusertib,CHEBI,CHEBI:94490,"N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide"
+danusertib,PUBCHEM,11442891,
+danusertib,CHEMBL,CHEMBL402548,
+danusertib,CHEBI,CHEBI:94490,"N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide"
+dapagliflozin,CHEBI,CHEBI:85078,dapagliflozin
+dapagliflozin,PUBCHEM,9887712,
+dasatinib,CHEBI,CHEBI:49375,dasatinib (anhydrous)
+dasatinib,PUBCHEM,3062316,
+DDR,GO,GO:0042769,"DNA damage response, detection of DNA damage"
+death receptor,FPLX,000137,Death_receptor
+death receptors,FPLX,000137,Death_receptor
+death,GO,GO:0008219,cell death
+death,MESH,D016923,Cell Death
+delta-tubulin,HGNC,16811,TUBD1
+desmoglein,FPLX,000138,Desmoglein
+desmogleins,FPLX,000138,Desmoglein
+dexamethasone,PUBCHEM,5743,
+dexamethasone,CHEBI,CHEBI:41879,dexamethasone
+DGC,FPLX,000139,DGC
+DGK,FPLX,000140,DGK
+DHA,CHEBI,CHEBI:207229,dihydroartemisinin
+DHA,PUBCHEM,6918483,
+DHT,PUBCHEM,11302,
+DHT,CHEBI,CHEBI:2150,5beta-dihydrotestosterone
+diacyl glycerol kinase,FPLX,000140,DGK
+diacylglycerol kinase,FPLX,000140,DGK
+differentiation,GO,GO:0030154,cell differentiation
+differentiation,MESH,D002454,Cell Differentiation
+diosmetin,CHEBI,CHEBI:4630,diosmetin
+diosmetin,PUBCHEM,5281612,
+discoidin domain receptor family,FPLX,000136,DDR
+discoidin domain receptors,FPLX,000136,DDR
+discoidin domain-containing receptor,FPLX,000136,DDR
+dishevelled,FPLX,000145,DVL
+DNA polymerase delta,FPLX,000141,DNA_polymerase_delta
+DNA polymerase δ,FPLX,000141,DNA_polymerase_delta
+DNA repair,GO,GO:0006281,DNA repair
+DNA repair,MESH,D004260,DNA Repair
+DNA replication factor C complex,FPLX,000411,RFC
+DNA replication factor C,FPLX,000411,RFC
+DNA-PKcs,UP,P78527,PRKDC_HUMAN
+DNA-Pkcs,UP,P78527,PRKDC_HUMAN
+docetaxel,PUBCHEM,148124,
+docetaxel,CHEBI,CHEBI:4672,docetaxel anhydrous
+Dok1,UP,Q99704,DOK1_HUMAN
+Dok2,UP,O60496,DOK2_HUMAN
+dopamine receptor,FPLX,000143,DRD
+dopamine receptors,FPLX,000143,DRD
+dopamine,PUBCHEM,681,
+dopamine,CHEBI,CHEBI:18243,dopamine
+doxorubicin,CHEBI,CHEBI:28748,doxorubicin
+doxorubicin,PUBCHEM,31703,
+doxycycline,PUBCHEM,54671203,
+doxycycline,CHEBI,CHEBI:50845,doxycycline
+DP complex,FPLX,000464,TFDP
+DR4,UP,O00220,TR10A_HUMAN
+DR5,UP,O14763,TR10B_HUMAN
+DSB,MESH,D053903,"DNA Breaks, Double-Stranded"
+DUSP,FPLX,000144,DUSP
+DUSP1,UP,P28562,DUS1_HUMAN
+Dvl,FPLX,000145,DVL
+dynamin family,FPLX,000142,DNM
+dynamin,FPLX,000142,DNM
+dystrophin glycoprotein complex,FPLX,000139,DGC
+dystrophin glycoprotein,FPLX,000139,DGC
+dystrophin-associated glycoprotein complex,FPLX,000139,DGC
+dystrophin-glycoprotein complex,FPLX,000139,DGC
+E-cadherin,UP,P12830,CADH1_HUMAN
+E2 enzyme,FPLX,000489,UBE2
+E2 ubiquitin-conjugating enzyme,FPLX,000489,UBE2
+E2,FPLX,000489,UBE2
+E2,UP,P27958,POLG_HCVH
+E2F,FPLX,000147,E2F
+E2F-1,UP,Q01094,E2F1_HUMAN
+E2F1,UP,Q01094,E2F1_HUMAN
+E3 ubiquitin ligase,FPLX,000148,E3_Ub_ligase
+E3,FPLX,000148,E3_Ub_ligase
+E6,UP,P03126,VE6_HPV16
+E7,UP,P03129,VE7_HPV16
+early growth response proteins,FPLX,000151,EGR
+EBNA3C,UP,I1YP21,
+ECM,GO,GO:0031012,extracellular matrix
+Ect2,UP,Q9H8V3,ECT2_HUMAN
+EGCG,PUBCHEM,65064,
+EGCG,CHEBI,CHEBI:4806,(-)-epigallocatechin 3-gallate
+EGF receptor,UP,P00533,EGFR_HUMAN
+EGF,UP,P01133,EGF_HUMAN
+EGFR ligand,FPLX,000150,EGFR_ligand
+EGFR ligands,FPLX,000150,EGFR_ligand
+EGFR,UP,P00533,EGFR_HUMAN
+EGFRvIII,UP,P00533,EGFR_HUMAN
+EGR,FPLX,000151,EGR
+eIF2alpha,UP,P05198,IF2A_HUMAN
+EIF2B,FPLX,000152,EIF2B
+eIF2B,FPLX,000152,EIF2B
+eIF2α,UP,P05198,IF2A_HUMAN
+eIF4A,FPLX,000153,EIF4A
+eIF4E,UP,P06730,IF4E_HUMAN
+eIF4G,FPLX,000155,EIF4G
+elastase,FPLX,000156,ELA
+Elk-1,UP,P19419,ELK1_HUMAN
+Elk1,UP,P19419,ELK1_HUMAN
+ELMO1,UP,Q92556,ELMO1_HUMAN
+ELR (+) CXC chemokines,FPLX,000129,CXCL_ELR_positive
+ELR (-) CXC chemokines,FPLX,000128,CXCL_ELR_negative
+ELR-negative CXC chemokine,FPLX,000128,CXCL_ELR_negative
+ELR-negative CXC family,FPLX,000128,CXCL_ELR_negative
+ELR-positive CXC chemokine,FPLX,000129,CXCL_ELR_positive
+ELR-positive CXC family,FPLX,000129,CXCL_ELR_positive
+embelin,CHEBI,CHEBI:4778,embelin
+embelin,PUBCHEM,3218,
+emodin,PUBCHEM,3220,
+emodin,CHEBI,CHEBI:42223,emodin
+EMT,GO,GO:0001837,epithelial to mesenchymal transition
+EMT,MESH,D058750,Epithelial-Mesenchymal Transition
+endocytosis,GO,GO:0006897,endocytosis
+endocytosis,MESH,D004705,Endocytosis
+endothelin,FPLX,000149,EDN
+endothelins,FPLX,000149,EDN
+enolase,FPLX,000157,ENO
+eNOS,UP,P29474,NOS3_HUMAN
+Env,UP,U3LIR9,
+Eph receptor,FPLX,000158,Ephrin_receptor
+Eph receptors,FPLX,000158,Ephrin_receptor
+EphA2,UP,P29317,EPHA2_HUMAN
+EphB1,UP,P54762,EPHB1_HUMAN
+ephrin receptor,FPLX,000158,Ephrin_receptor
+epidermal growth factor receptor,UP,P00533,EGFR_HUMAN
+epidermal growth factor,UP,P01133,EGF_HUMAN
+Eps8,UP,Q12929,EPS8_HUMAN
+epsilon-tubulin,HGNC,20775,TUBE1
+epsin,FPLX,000159,EPN
+epsins,FPLX,000159,EPN
+ER,FPLX,000162,ESR
+ER,MESH,D004721,Endoplasmic Reticulum
+ER,GO,GO:0005783,endoplasmic reticulum
+ER,UP,P03372,ESR1_HUMAN
+ERalpha,UP,P03372,ESR1_HUMAN
+ErbB,FPLX,000160,ERBB
+ERBB2,UP,P04626,ERBB2_HUMAN
+ErbB2,UP,P04626,ERBB2_HUMAN
+ErbB3,UP,P21860,ERBB3_HUMAN
+ERK 1/2,FPLX,000161,ERK
+ERK inhibitors,CHEBI,CHEBI:79091,EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
+ERK MAPK,FPLX,000161,ERK
+ERK mitogen-activated protein kinase,FPLX,000161,ERK
+ERK,FPLX,000161,ERK
+Erk,FPLX,000161,ERK
+ERK-1/2,FPLX,000161,ERK
+ERK1,UP,P27361,MK03_HUMAN
+Erk1,UP,P27361,MK03_HUMAN
+ERK1/2 MAPK,FPLX,000161,ERK
+ERK1/2,FPLX,000161,ERK
+Erk1/2,FPLX,000161,ERK
+ERK2,UP,P28482,MK01_HUMAN
+ERK5,UP,Q13164,MK07_HUMAN
+ERKs,FPLX,000161,ERK
+erlotinib,PUBCHEM,176870,
+erlotinib,CHEBI,CHEBI:114785,erlotinib
+ERα,UP,P03372,ESR1_HUMAN
+ESR,FPLX,000162,ESR
+estradiol,CHEBI,CHEBI:23965,estradiol
+estradiol,PUBCHEM,9811784,
+estrogen receptor,UP,P03372,ESR1_HUMAN
+estrogen,CHEBI,CHEBI:50114,estrogen
+ET-1,UP,P05305,EDN1_HUMAN
+ethanol,PUBCHEM,702,
+ethanol,CHEBI,CHEBI:16236,ethanol
+ethanol,HMDB,HMDB00108,
+etoposide,PUBCHEM,36462,
+etoposide,CHEBI,CHEBI:4911,etoposide
+ETS,FPLX,000163,ETS
+ETS-1,UP,P14921,ETS1_HUMAN
+Ets-1,UP,P14921,ETS1_HUMAN
+ETS1,UP,P14921,ETS1_HUMAN
+eukaryotic initiation factor 4E,UP,P06730,IF4E_HUMAN
+eukaryotic initiation factor-4A,FPLX,000153,EIF4A
+Everolimus,PUBCHEM,6442177,
+Everolimus,CHEBI,CHEBI:68478,everolimus
+everolimus,PUBCHEM,6442177,
+everolimus,CHEBI,CHEBI:68478,everolimus
+EXOC,FPLX,000164,EXOC
+exocyst complex,FPLX,000164,EXOC
+exocyst,FPLX,000164,EXOC
+Exostosin glycosyltransferase family,FPLX,000165,EXT
+exostosin glycosyltransferase family,FPLX,000165,EXT
+EXT,FPLX,000165,EXT
+Extracellular Signal Regulated Kinase,FPLX,000161,ERK
+extracellular signal-regulated kinase,FPLX,000161,ERK
+EZH2,UP,Q15910,EZH2_HUMAN
+ezrin,UP,P15311,EZRI_HUMAN
+F-actin,FPLX,000178,F_actin
+FADD,UP,Q13158,FADD_HUMAN
+FAK,UP,Q05397,FAK1_HUMAN
+FAM83B,UP,Q5T0W9,FA83B_HUMAN
+FANC proteins,FPLX,000166,FANC
+FANC,FPLX,000166,FANC
+FANCJ,UP,Q9BX63,FANCJ_HUMAN
+farnesyltransferase,FPLX,000172,FNT
+Fas,UP,P25445,TNR6_HUMAN
+FasL,UP,P48023,TNFL6_HUMAN
+FGF,FPLX,000167,FGF
+FGF-2,UP,P09038,FGF2_HUMAN
+FGF2,UP,P09038,FGF2_HUMAN
+FGFR,FPLX,000168,FGFR
+FGFR1,UP,P11362,FGFR1_HUMAN
+FGFR2,UP,P21802,FGFR2_HUMAN
+FGFR3,UP,P22607,FGFR3_HUMAN
+FGFR4,UP,P22455,FGFR4_HUMAN
+fibrinogen,FPLX,000169,Fibrinogen
+fibronectin,UP,P02751,FINC_HUMAN
+fisetin,CHEBI,CHEBI:42567,fisetin
+fisetin,PUBCHEM,5281614,
+Flip,UP,O15519,CFLAR_HUMAN
+flotillin,FPLX,000170,FLOT
+FLRT family,FPLX,000171,FLRT
+Flrt family,FPLX,000171,FLRT
+FLRT proteins,FPLX,000171,FLRT
+FLT3,UP,P36888,FLT3_HUMAN
+FN,UP,P02751,FINC_HUMAN
+follicle-stimulating hormone,FPLX,000175,FSH
+FOS,FPLX,000173,FOS_family
+Fos,FPLX,000173,FOS_family
+FOXM1,UP,Q08050,FOXM1_HUMAN
+FOXO,FPLX,000174,FOXO
+FoxO,FPLX,000174,FOXO
+FOXO1,UP,Q12778,FOXO1_HUMAN
+FoxO1,UP,Q12778,FOXO1_HUMAN
+FOXO3,UP,O43524,FOXO3_HUMAN
+FOXO3a,UP,O43524,FOXO3_HUMAN
+FoxO3a,UP,O43524,FOXO3_HUMAN
+FRK,UP,P42685,FRK_HUMAN
+fructose-bisphosphate aldolase,FPLX,000025,ALDO
+FSH,FPLX,000175,FSH
+FTase,FPLX,000172,FNT
+FTS,PUBCHEM,5469318,
+Fucosyltransferase,FPLX,000176,FUT
+Fucosyltransferases,FPLX,000176,FUT
+fucosyltransferase,FPLX,000176,FUT
+fucosyltransferases,FPLX,000176,FUT
+FUT,FPLX,000176,FUT
+Fyn,UP,P06241,FYN_HUMAN
+Fz,FPLX,000177,FZD
+FZD,FPLX,000177,FZD
+G 1,GO,GO:0051318,G1 phase
+G 1,MESH,D016193,G1 Phase
+G 2,MESH,D016195,G2 Phase
+G alphai,FPLX,000213,G_i_alpha
+G alphaq,FPLX,000216,G_q_alpha
+G alphaS,FPLX,000218,G_s_alpha
+G protein beta,FPLX,000210,G_beta
+G protein gamma subunit,FPLX,000211,G_gamma
+G protein gamma,FPLX,000211,G_gamma
+G protein Gs,FPLX,000217,G_s
+G protein γ subunit,FPLX,000211,G_gamma
+G protein β,FPLX,000210,G_beta
+G protein γ,FPLX,000211,G_gamma
+G protein(s),FPLX,000217,G_s
+G protein,FPLX,000214,G_protein
+G protein-coupled receptor kinases,FPLX,000192,GRK
+G proteins,FPLX,000214,G_protein
+G S protein,FPLX,000217,G_s
+G αi,FPLX,000213,G_i_alpha
+G αq,FPLX,000216,G_q_alpha
+G αS,FPLX,000218,G_s_alpha
+G(12),FPLX,000207,G_12
+G(q/11),FPLX,000215,G_q
+G-alpha(s),FPLX,000218,G_s_alpha
+G-AlphaS,FPLX,000218,G_s_alpha
+G-protein alpha-12,FPLX,000208,G_12_alpha
+G-Protein alpha-i,FPLX,000213,G_i_alpha
+G-Protein alpha-q,FPLX,000216,G_q_alpha
+G-Protein alpha-s,FPLX,000218,G_s_alpha
+G-protein beta,FPLX,000210,G_beta
+G-protein β,FPLX,000210,G_beta
+G-protein α-12,FPLX,000208,G_12_alpha
+G-Protein α-i,FPLX,000213,G_i_alpha
+G-Protein α-q,FPLX,000216,G_q_alpha
+G-Protein α-s,FPLX,000218,G_s_alpha
+G-α(s),FPLX,000218,G_s_alpha
+G-αS,FPLX,000218,G_s_alpha
+G12 family,FPLX,000207,G_12
+G12 proteins,FPLX,000207,G_12
+G12,FPLX,000207,G_12
+GA,PUBCHEM,370,
+GA,CHEBI,CHEBI:30778,gallic acid
+Ga12,FPLX,000208,G_12_alpha
+Gab1,UP,Q13480,GAB1_HUMAN
+Gab2,UP,Q9UQC2,GAB2_HUMAN
+GABA receptor,FPLX,000179,GABR
+GABA receptors,FPLX,000179,GABR
+GABA-A receptor,FPLX,000179,GABR
+GALNT,FPLX,000180,GALNT
+Galpha12,FPLX,000208,G_12_alpha
+Galphai,FPLX,000213,G_i_alpha
+Galphaq,FPLX,000216,G_q_alpha
+GalphaS,FPLX,000218,G_s_alpha
+gamma secretase,FPLX,000181,Gamma_secretase
+Gamma tubulin,FPLX,000485,TUBG
+gamma tubulin,FPLX,000485,TUBG
+gamma-aminobutyric-acid A receptor,FPLX,000179,GABR
+gamma-secretase,FPLX,000181,Gamma_secretase
+gamma-tubulin,FPLX,000485,TUBG
+GAP,FPLX,000182,GAP
+Gas6 receptors,FPLX,000183,GAS6_receptor
+gastrin,UP,P01350,GAST_HUMAN
+GATA family,FPLX,000184,GATA
+GATA,FPLX,000184,GATA
+Gbeta,FPLX,000210,G_beta
+GCNT,FPLX,000185,GCNT
+GDF15,UP,Q99988,GDF15_HUMAN
+GDP,HMDB,HMDB01201,
+GDP,PUBCHEM,135398619,
+GDP,CHEBI,CHEBI:17552,GDP
+GEF,FPLX,000186,GEF
+GEF-H1,UP,Q92974,ARHG2_HUMAN
+gefitinib,PUBCHEM,123631,
+gefitinib,CHEBI,CHEBI:49668,gefitinib
+GEFs,FPLX,000186,GEF
+general transcription factor II E,FPLX,000196,GTF2E
+general transcription factor II F,FPLX,000197,GTF2F
+genistein,CHEBI,CHEBI:28088,genistein
+genistein,PUBCHEM,5280961,
+Gi alpha subunit,FPLX,000213,G_i_alpha
+Gi alpha,FPLX,000213,G_i_alpha
+Gi protein,FPLX,000212,G_i
+Gi α subunit,FPLX,000213,G_i_alpha
+Gi α,FPLX,000213,G_i_alpha
+Gi,FPLX,000212,G_i
+GII PLA2,FPLX,000367,PLA2G2
+GIIPLA2,FPLX,000367,PLA2G2
+gIV-PLA(2),FPLX,000368,PLA2G4
+glucose transporter,FPLX,000434,SLC2A
+glucose transporters,FPLX,000434,SLC2A
+Glucose,HMDB,HMDB00122,
+glucose,HMDB,HMDB00122,
+GLUT,FPLX,000434,SLC2A
+glutamate metabotropic receptors,FPLX,000193,GRM
+glutathione peroxidase,FPLX,000190,GPX
+glutathione S-transferase,FPLX,000195,GST
+glutathione,PUBCHEM,124886,
+glutathione,CHEBI,CHEBI:16856,glutathione
+glutathione,HMDB,HMDB00125,
+Glycogen phosphorylase,FPLX,000396,PYG
+Glycogen phosphorylases,FPLX,000396,PYG
+glycogen phosphorylase,FPLX,000396,PYG
+glycogen phosphorylases,FPLX,000396,PYG
+glycogen synthase,FPLX,000206,GYS
+glycolysis,GO,GO:0006096,glycolytic process
+glycolysis,MESH,D006019,Glycolysis
+glycoprotein Ib-V-IX complex,FPLX,000188,GPIb_IX_V
+Glycoprotein Ib-V-IX,FPLX,000188,GPIb_IX_V
+Glycoprotein Ib/V/IX,FPLX,000188,GPIb_IX_V
+glycosylphosphatidylinositol transamidase complex,FPLX,000189,GPIT
+Glycosyltransferase family 2,FPLX,000199,GTF_family_2
+glycosyltransferase family 2,FPLX,000199,GTF_family_2
+Glycosyltransferase family 29,FPLX,000202,GTF_family_29
+glycosyltransferase family 29,FPLX,000202,GTF_family_29
+Glycosyltransferase family 6,FPLX,000200,GTF_family_6
+glycosyltransferase family 6,FPLX,000200,GTF_family_6
+Glycosyltransferase family 8,FPLX,000201,GTF_family_8
+glycosyltransferase family 8,FPLX,000201,GTF_family_8
+Glycosyltransferase family 90,FPLX,000203,GTF_family_90
+glycosyltransferase family 90,FPLX,000203,GTF_family_90
+gp120,UP,P04578,ENV_HV1H2
+gp47 phox,UP,P14598,NCF1_HUMAN
+gp91 phox,UP,P04839,CY24B_HUMAN
+GPCR kinases,FPLX,000192,GRK
+GPCR,FPLX,000187,GPCR
+GPCRs,FPLX,000187,GPCR
+GPI transamidase complex,FPLX,000189,GPIT
+GPIb-IX-V complex,FPLX,000188,GPIb_IX_V
+GPIb-IX-V,FPLX,000188,GPIb_IX_V
+GpIb-V-IX,FPLX,000188,GPIb_IX_V
+GPIT complex,FPLX,000189,GPIT
+GPIT,FPLX,000189,GPIT
+Gq alpha subunit,FPLX,000216,G_q_alpha
+Gq alpha,FPLX,000216,G_q_alpha
+Gq α subunit,FPLX,000216,G_q_alpha
+Gq α,FPLX,000216,G_q_alpha
+Gq/11,FPLX,000215,G_q
+GR,UP,P00390,GSHR_HUMAN
+GRB2,UP,P62993,GRB2_HUMAN
+Grb2,UP,P62993,GRB2_HUMAN
+GRK,FPLX,000192,GRK
+GRKs,FPLX,000192,GRK
+group IV-PLA(2),FPLX,000368,PLA2G4
+GRP78,UP,P11021,BIP_HUMAN
+Gs alpha subunit,FPLX,000218,G_s_alpha
+Gs alpha,FPLX,000218,G_s_alpha
+Gs family,FPLX,000217,G_s
+Gs protein,FPLX,000217,G_s
+Gs α subunit,FPLX,000218,G_s_alpha
+Gs α,FPLX,000218,G_s_alpha
+GSH,PUBCHEM,124886,
+GSH,CHEBI,CHEBI:16856,glutathione
+GSH,HMDB,HMDB00125,
+GSK-3,FPLX,000194,GSK3
+GSK-3beta,UP,P49841,GSK3B_HUMAN
+GSK-3β,UP,P49841,GSK3B_HUMAN
+GSK3,FPLX,000194,GSK3
+GSK3beta,UP,P49841,GSK3B_HUMAN
+GSK3β,UP,P49841,GSK3B_HUMAN
+GST,FPLX,000195,GST
+GSTs,FPLX,000195,GST
+GTP,HMDB,HMDB01273,
+GTP,CHEBI,CHEBI:15996,GTP
+GTP,PUBCHEM,135398633,
+GTPase,FPLX,000204,GTPase
+GTPase-activating proteins,FPLX,000182,GAP
+guanine,PUBCHEM,135398634,
+guanine,CHEBI,CHEBI:16235,guanine
+guanylate cyclase,FPLX,000205,GUCY
+guanylyl cyclase,FPLX,000205,GUCY
+G_alpha,FPLX,000209,G_alpha
+G_α,FPLX,000209,G_alpha
+Gβ,FPLX,000210,G_beta
+Gα12,FPLX,000208,G_12_alpha
+Gαi,FPLX,000213,G_i_alpha
+Gαq,FPLX,000216,G_q_alpha
+GαS,FPLX,000218,G_s_alpha
+H-Ras,UP,P01112,RASH_HUMAN
+H/R,MESH,D015687,Cell Hypoxia
+H2AX,UP,P16104,H2AX_HUMAN
+H2B,FPLX,000236,Histone_H2B
+H3,FPLX,000237,Histone_H3
+h9-1-1 complex,FPLX,000001,9_1_1
+haem oxygenase,FPLX,000240,HMOX
+hAxin,FPLX,000062,AXIN
+HB-EGF,UP,Q99075,HBEGF_HUMAN
+HBx,UP,Q157B2,
+hCG,FPLX,000219,hCG
+HDAC inhibitor,CHEBI,CHEBI:61115,EC 3.5.1.98 (histone deacetylase) inhibitor
+HDAC,FPLX,000220,HDAC
+HDAC1,UP,Q13547,HDAC1_HUMAN
+HDAC2,UP,Q92769,HDAC2_HUMAN
+HDAC3,UP,O15379,HDAC3_HUMAN
+HDACi,CHEBI,CHEBI:61115,EC 3.5.1.98 (histone deacetylase) inhibitor
+HDL,FPLX,000225,HDL
+HDM2,UP,Q00987,MDM2_HUMAN
+Heat Shock Protein 70,FPLX,000244,HSPA
+heat shock protein family B,FPLX,000245,HSPB
+Hedgehog family,FPLX,000226,Hedgehog
+hedgehog protein,FPLX,000226,Hedgehog
+hedgehog signaling proteins,FPLX,000226,Hedgehog
+Hedgehog,FPLX,000226,Hedgehog
+heme oxygenase,FPLX,000240,HMOX
+hemoglobin,FPLX,000227,Hemoglobin
+HER-2,UP,P04626,ERBB2_HUMAN
+HER2 receptor,UP,P04626,ERBB2_HUMAN
+HER2,UP,P04626,ERBB2_HUMAN
+HER3,UP,P21860,ERBB3_HUMAN
+Hes gene family,FPLX,000228,HES
+Hes genes,FPLX,000228,HES
+HES,FPLX,000228,HES
+Hes,FPLX,000228,HES
+HG,HMDB,HMDB00122,
+HGF,UP,P14210,HGF_HUMAN
+Hic-5,UP,O43294,TGFI1_HUMAN
+HIF,FPLX,000229,HIF
+HIF-1,FPLX,000230,HIF1
+HIF-1alpha protein,UP,Q16665,HIF1A_HUMAN
+HIF-1alpha,UP,Q16665,HIF1A_HUMAN
+HIF-1α protein,UP,Q16665,HIF1A_HUMAN
+HIF-1α,UP,Q16665,HIF1A_HUMAN
+HIF1alpha protein,UP,Q16665,HIF1A_HUMAN
+HIF1alpha,UP,Q16665,HIF1A_HUMAN
+HIF1α protein,UP,Q16665,HIF1A_HUMAN
+HIF1α,UP,Q16665,HIF1A_HUMAN
+HIFalpha,FPLX,000231,HIF_alpha
+Hifalpha,FPLX,000231,HIF_alpha
+HIFbeta,FPLX,000232,HIF_beta
+Hifbeta,FPLX,000232,HIF_beta
+HIFs,FPLX,000229,HIF
+HIFα,FPLX,000231,HIF_alpha
+Hifα,FPLX,000231,HIF_alpha
+HIFβ,FPLX,000232,HIF_beta
+Hifβ,FPLX,000232,HIF_beta
+High-density lipoproteins,FPLX,000225,HDL
+HIPK2,UP,Q9H2X6,HIPK2_HUMAN
+Histone 2A,FPLX,000235,Histone_H2A
+histone deacetylase,FPLX,000220,HDAC
+histone deacetylases,FPLX,000220,HDAC
+histone H1,FPLX,000234,Histone_H1
+Histone H2A,FPLX,000235,Histone_H2A
+histone H2A,FPLX,000235,Histone_H2A
+histone H2B,FPLX,000236,Histone_H2B
+histone H3,FPLX,000237,Histone_H3
+histone H4,FPLX,000238,Histone_H4
+Histone,FPLX,000233,Histone
+histone,FPLX,000233,Histone
+histone-3,FPLX,000237,Histone_H3
+histones,FPLX,000233,Histone
+HLA-DR,FPLX,000239,HLA_DR
+HMGB1,UP,P09429,HMGB1_HUMAN
+HO-1,UP,P09601,HMOX1_HUMAN
+homeodomain iroquois proteins,FPLX,000265,IRX
+HOTAIR,HGNC,33510,HOTAIR
+HOTAIR,NONCODE,NONHSAT028507.2,
+HOTAIR,LNCRNADB,HOTAIR,
+HR,GO,GO:0000725,recombinational repair
+HR,MESH,D059767,Recombinational DNA Repair
+HRAS,UP,P01112,RASH_HUMAN
+HRASV12,UP,P01112,RASH_HUMAN
+HSF1,UP,Q00613,HSF1_HUMAN
+HSP20,UP,O14558,HSPB6_HUMAN
+HSP27,UP,P04792,HSPB1_HUMAN
+HSP70,FPLX,000244,HSPA
+Hsp70,FPLX,000244,HSPA
+HSP90,FPLX,000241,HSP90
+Hsp90,FPLX,000241,HSP90
+HSP90A,FPLX,000242,HSP90A
+HSP90AA,FPLX,000243,HSP90AA
+HSPB proteins,FPLX,000245,HSPB
+HSPB,FPLX,000245,HSPB
+hTERT,UP,O14746,TERT_HUMAN
+HuR,HGNC,3312,ELAVL1
+HuR,UP,Q15717,ELAV1_HUMAN
+hydrogen peroxide,PUBCHEM,784,
+hydrogen peroxide,CHEBI,CHEBI:16240,hydrogen peroxide
+hypoxia-inducible factors,FPLX,000229,HIF
+I/R,MESH,D011839,"Radiation, Ionizing"
+ICAM-1,UP,P05362,ICAM1_HUMAN
+IER3,UP,P46695,IEX1_HUMAN
+IFI16,UP,Q16666,IF16_HUMAN
+IFN,FPLX,000262,Interferon
+IFN-a,FPLX,000246,IFNA
+IFN-alpha,FPLX,000246,IFNA
+IFN-beta,FPLX,000247,IFNB
+IFN-beta,UP,P01574,IFNB_HUMAN
+IFN-gamma,UP,P01579,IFNG_HUMAN
+IFN-α,FPLX,000246,IFNA
+IFN-β,FPLX,000247,IFNB
+IFN-β,UP,P01574,IFNB_HUMAN
+IFN-γ,UP,P01579,IFNG_HUMAN
+IFNalpha,FPLX,000246,IFNA
+IFNgamma,UP,P01579,IFNG_HUMAN
+IFNGR,FPLX,000263,Interferon_gamma_receptor
+IFNα,FPLX,000246,IFNA
+IFNγ,UP,P01579,IFNG_HUMAN
+IGF-1,UP,P05019,IGF1_HUMAN
+IGF-1R,UP,P08069,IGF1R_HUMAN
+IGF-1Rbeta,UP,P08069,IGF1R_HUMAN
+IGF-1Rβ,UP,P08069,IGF1R_HUMAN
+IGF-BP,FPLX,000248,IGFBP
+IGF-I,UP,P05019,IGF1_HUMAN
+IGF-IR,UP,P08069,IGF1R_HUMAN
+IGF1,UP,P05019,IGF1_HUMAN
+IGF1R,UP,P08069,IGF1R_HUMAN
+IGFBP,FPLX,000248,IGFBP
+IGFBPs,FPLX,000248,IGFBP
+IkappaB kinase,FPLX,000251,IKK_family
+IkappaB,FPLX,000249,IKB
+IkappaB-alpha,HGNC,7797,NFKBIA
+IkappaBalpha,UP,P25963,IKBA_HUMAN
+IKK complex,FPLX,000250,IKK_complex
+IKK,FPLX,000251,IKK_family
+IKKalpha,UP,O15111,IKKA_HUMAN
+IKKbeta,UP,O14920,IKKB_HUMAN
+IKKβ,UP,O14920,IKKB_HUMAN
+IKKα,UP,O15111,IKKA_HUMAN
+IL-1,FPLX,000252,IL1
+IL-10,UP,P22301,IL10_HUMAN
+IL-12,FPLX,000253,IL12
+IL-15 receptor,FPLX,000254,IL15R
+IL-15R,FPLX,000254,IL15R
+IL-17,UP,Q16552,IL17_HUMAN
+IL-18,UP,Q14116,IL18_HUMAN
+IL-1beta,UP,P01584,IL1B_HUMAN
+IL-1β,UP,P01584,IL1B_HUMAN
+IL-2 receptor,FPLX,000255,IL2R
+IL-2,UP,P60568,IL2_HUMAN
+IL-2R,FPLX,000255,IL2R
+IL-4,UP,P05112,IL4_HUMAN
+IL-6,UP,P05231,IL6_HUMAN
+IL-8,UP,P10145,IL8_HUMAN
+IL1 family,FPLX,000252,IL1
+IL12,FPLX,000253,IL12
+imatinib,PUBCHEM,5291,
+imatinib,LINCS,10023-103,
+imatinib,CHEBI,CHEBI:45783,imatinib
+immune response,GO,GO:0006955,immune response
+infiltration,MESH,D009361,Neoplasm Invasiveness
+inflammation,GO,GO:0006954,inflammatory response
+inflammation,MESH,D007249,Inflammation
+inflammatory response,GO,GO:0006954,inflammatory response
+inflammatory response,MESH,0007249,
+inhibin A,FPLX,000257,Inhibin_A
+inhibin B,FPLX,000258,Inhibin_B
+Inhibin,FPLX,000256,Inhibin
+inhibin,FPLX,000256,Inhibin
+inhibin-A,FPLX,000257,Inhibin_A
+inhibin-a,FPLX,000257,Inhibin_A
+inhibin-B,FPLX,000258,Inhibin_B
+inhibin-b,FPLX,000258,Inhibin_B
+initiation factor 4E binding proteins,FPLX,000154,EIF4EBP
+iNOS,UP,P35228,NOS2_HUMAN
+insulin family,FPLX,000259,INS
+Insulin receptor family,FPLX,000260,INSR
+insulin receptor family,FPLX,000260,INSR
+insulin receptor substrate,FPLX,000264,IRS
+insulin receptor,UP,P06213,INSR_HUMAN
+insulin receptor/insulin-like growth factor receptor family,FPLX,000260,INSR
+Insulin,UP,P01308,INS_HUMAN
+insulin,UP,P01308,INS_HUMAN
+insulin-like growth factor binding proteins,FPLX,000248,IGFBP
+integrin,FPLX,000261,Integrins
+integrins,FPLX,000261,Integrins
+Interferon beta,FPLX,000247,IFNB
+interferon beta,FPLX,000247,IFNB
+interferon gamma receptor,FPLX,000263,Interferon_gamma_receptor
+interferon γ receptor,FPLX,000263,Interferon_gamma_receptor
+Interferon β,FPLX,000247,IFNB
+interferon β,FPLX,000247,IFNB
+interferon,FPLX,000262,Interferon
+interferon-gamma receptor,FPLX,000263,Interferon_gamma_receptor
+interferon-γ receptor,FPLX,000263,Interferon_gamma_receptor
+invasion,MESH,D009361,Neoplasm Invasiveness
+invasiveness,MESH,D009361,Neoplasm Invasiveness
+IQGAP1,UP,P46940,IQGA1_HUMAN
+IR,MESH,D011839,"Radiation, Ionizing"
+IR,UP,P06213,INSR_HUMAN
+IRF3,UP,Q14653,IRF3_HUMAN
+iron,PUBCHEM,23925,
+iron,CHEBI,CHEBI:18248,iron atom
+Iroquois family,FPLX,000265,IRX
+Iroquois proteins,FPLX,000265,IRX
+Iroquois-class homeodomain proteins,FPLX,000265,IRX
+IRS family,FPLX,000264,IRS
+IRS,FPLX,000264,IRS
+IRS-1,UP,P35568,IRS1_HUMAN
+IRS-2,UP,Q9Y4H2,IRS2_HUMAN
+IRS1,UP,P35568,IRS1_HUMAN
+IRS2,UP,Q9Y4H2,IRS2_HUMAN
+isoflurane,PUBCHEM,3763,
+isoflurane,CHEBI,CHEBI:6015,isoflurane
+IκB kinase,FPLX,000251,IKK_family
+IκB,FPLX,000249,IKB
+IκB-α,HGNC,7797,NFKBIA
+IκBα,UP,P25963,IKBA_HUMAN
+JAK,FPLX,000266,JAK
+Jak,FPLX,000266,JAK
+JAK2,UP,O60674,JAK2_HUMAN
+JAKs,FPLX,000266,JAK
+JNK MAPK,FPLX,000267,JNK
+JNK,FPLX,000267,JNK
+JNK1,UP,P45983,MK08_HUMAN
+JNK1/2,FPLX,000267,JNK
+JNKs,FPLX,000267,JNK
+JQ1,PUBCHEM,46907787,
+JQ1,CHEBI,CHEBI:95080,LSM-6332
+JUN,FPLX,000268,JUN_family
+K-Ras,UP,P01116,RASK_HUMAN
+Kainate receptors,FPLX,000269,Kainate_family
+kallikrein,FPLX,000271,KLK
+kallikrein-related peptidases,FPLX,000271,KLK
+KARs,FPLX,000269,Kainate_family
+Keap1,UP,Q14145,KEAP1_HUMAN
+kinetochore centromere binding factor 3,FPLX,000084,CBF3
+kinetochore complex,FPLX,000270,Kinetochore
+kinetochore,FPLX,000270,Kinetochore
+kinetochores,FPLX,000270,Kinetochore
+KLF5,UP,Q13887,KLF5_HUMAN
+Klf5,UP,Q13887,KLF5_HUMAN
+KLKs,FPLX,000271,KLK
+KRAS,UP,P01116,RASK_HUMAN
+Kras,UP,P01116,RASK_HUMAN
+KSR,FPLX,000272,KSR
+LA,CHEBI,CHEBI:30314,(R)-lipoic acid
+LA,PUBCHEM,6112,
+lactate,PUBCHEM,91435,
+lactate,CHEBI,CHEBI:24996,lactate
+laminin 332 chains,FPLX,000274,Laminin_332
+laminin 332,FPLX,000274,Laminin_332
+laminin-332 chains,FPLX,000274,Laminin_332
+laminin-332,FPLX,000274,Laminin_332
+Laminin-5,FPLX,000274,Laminin_332
+laminin-5,FPLX,000274,Laminin_332
+lapatinib,PUBCHEM,208908,
+lapatinib,CHEBI,CHEBI:49603,lapatinib
+LAT,UP,O43561,LAT_HUMAN
+LC3,FPLX,000280,MAP1LC3
+Lck,UP,P06239,LCK_HUMAN
+LDH,FPLX,000275,LDH
+lead,PUBCHEM,5352425,
+lead,CHEBI,CHEBI:25016,lead atom
+leptin,UP,P41159,LEP_HUMAN
+LFA-1 (integrin),FPLX,000261,Integrins
+LH,FPLX,000276,LH
+LIF,UP,P15018,LIF_HUMAN
+lipopolysaccharide,CHEBI,CHEBI:16412,lipopolysaccharide
+lipopolysaccharide,MESH,D008070,Lipopolysaccharides
+LKB1,UP,Q15831,STK11_HUMAN
+LM-1,FPLX,000273,Laminin_111
+LMP1,UP,P03230,LMP1_EBVB9
+localization,GO,GO:0051179,localization
+long-chain acyl-CoA synthetase,FPLX,000008,ACSL
+LPA,UP,P08519,APOA_HUMAN
+LPS,CHEBI,CHEBI:16412,lipopolysaccharide
+LPS,MESH,D008070,Lipopolysaccharides
+LRRK2,UP,Q5S007,LRRK2_HUMAN
+Luteinizing hormone,FPLX,000276,LH
+luteinizing hormone,FPLX,000276,LH
+luteinizing-hormone,FPLX,000276,LH
+luteolin,PUBCHEM,5280445,
+luteolin,CHEBI,CHEBI:15864,luteolin
+MA,PUBCHEM,10836,
+MA,CHEBI,CHEBI:6809,methamphetamine
+MA,PUBCHEM,73659,
+MA,CHEBI,CHEBI:66682,maslinic acid
+MA,UP,P04591,GAG_HV1H2
+MAC,FPLX,000278,MAC
+MAC-1 (integrin),FPLX,000261,Integrins
+Mad2,UP,Q13257,MD2L1_HUMAN
+Maf subfamily,FPLX,000279,MAF
+MAF,FPLX,000279,MAF
+Maf,FPLX,000279,MAF
+maf,FPLX,000279,MAF
+MAF,UP,O75444,MAF_HUMAN
+Maf,UP,O75444,MAF_HUMAN
+maf,UP,O75444,MAF_HUMAN
+mammalian target of rapamycin,UP,P42345,MTOR_HUMAN
+mangiferin,CHEBI,CHEBI:6682,mangiferin
+mangiferin,PUBCHEM,5281647,
+MAP kinase,FPLX,000283,MAPK
+MAP kinases,FPLX,000283,MAPK
+MAP2K1,UP,Q02750,MP2K1_HUMAN
+MAP2K2,UP,P36507,MP2K2_HUMAN
+MAP3K,FPLX,000282,MAP3K
+MAP3K2,UP,Q9Y2U5,M3K2_HUMAN
+MAPK kinase kinase,FPLX,000282,MAP3K
+MAPK kinase,FPLX,000281,MAP2K
+MAPK p38,FPLX,000326,p38
+MAPK,FPLX,000161,ERK
+MAPK1,UP,P28482,MK01_HUMAN
+MAPK3,UP,P27361,MK03_HUMAN
+MAPKK kinases,FPLX,000282,MAP3K
+MAPKKK,FPLX,000282,MAP3K
+MAPKs,FPLX,000283,MAPK
+MAZ,UP,P56270,MAZ_HUMAN
+Mcl-1,UP,Q07820,MCL1_HUMAN
+MCM,FPLX,000284,MCM
+MCP-1,UP,P0CW71,
+MDM2,UP,Q00987,MDM2_HUMAN
+Mdm2,UP,Q00987,MDM2_HUMAN
+MDMX,UP,O15151,MDM4_HUMAN
+Mdmx,UP,O15151,MDM4_HUMAN
+MED14,UP,O60244,MED14_HUMAN
+MED23,UP,Q9ULK4,MED23_HUMAN
+MEF2 family,FPLX,000285,MEF2
+MEF2,FPLX,000285,MEF2
+MEF2C,UP,Q06413,MEF2C_HUMAN
+MEK 1/2,FPLX,000286,MEK
+MEK inhibitor,CHEBI,CHEBI:88286,EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor
+MEK inhibitors,CHEBI,CHEBI:88286,EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor
+MEK,FPLX,000286,MEK
+MEK1,UP,Q02750,MP2K1_HUMAN
+MEK1/2,FPLX,000286,MEK
+melanin,PUBCHEM,6325610,
+melanin,CHEBI,CHEBI:89634,Melanin
+melatonin,CHEBI,CHEBI:16796,melatonin
+melatonin,PUBCHEM,896,
+membrane attack complex,FPLX,000278,MAC
+membrane attack,FPLX,000278,MAC
+MET,UP,P08581,MET_HUMAN
+Met,UP,P08581,MET_HUMAN
+metabolism,GO,GO:0008152,metabolic process
+metabolism,MESH,D008660,Metabolism
+metabotrophic glutamate receptor,FPLX,000193,GRM
+metabotropic glutamate receptor,FPLX,000193,GRM
+metastasis,MESH,D009362,Neoplasm Metastasis
+Metformin,PUBCHEM,4091,
+Metformin,CHEBI,CHEBI:6801,metformin
+metformin,PUBCHEM,4091,
+metformin,CHEBI,CHEBI:6801,metformin
+Metallothionein,FPLX,000292,Metallothionein
+metallothionein,FPLX,000292,Metallothionein
+MG132,PUBCHEM,462382,
+MG132,CHEBI,CHEBI:75142,N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
+mGluRs,FPLX,000193,GRM
+MIF,UP,P14174,MIF_HUMAN
+mini-chromosome maintenance complex,FPLX,000284,MCM
+minichromosome maintenance complex,FPLX,000284,MCM
+minichromosome maintenance protein complex,FPLX,000284,MCM
+miR-101,MESH,C534072,"MIRN101 microRNA, human"
+miR-101,MIRBASE,MI0000103,hsa-mir-101-1
+miR-101,HGNC,31488,MIR101-1
+miR-145,MIRBASE,MI0000461,hsa-mir-145
+miR-145,HGNC,31532,MIR145
+miR-155,MIRBASE,MI0000681,hsa-mir-155
+miR-155,HGNC,31542,MIR155
+miR-21,MIRBASE,MI0000077,hsa-mir-21
+miR-21,HGNC,31586,MIR21
+miR-7,MIRBASE,MI0000263,hsa-mir-7-1
+miR-7,HGNC,31638,MIR7-1
+MITF,UP,O75030,MITF_HUMAN
+mammalian mitochondrial ribosome,FPLX,000288,Mitochondrial_Ribosome
+Mitochondrial ribosome,FPLX,000288,Mitochondrial_Ribosome
+Mitochondrial Ribosome,FPLX,000288,Mitochondrial_Ribosome
+mitochondrial ribosomes,FPLX,000288,Mitochondrial_Ribosome
+Mitochondrial ribosomes,FPLX,000288,Mitochondrial_Ribosome
+Mitochondrial Ribosomes,FPLX,000288,Mitochondrial_Ribosome
+mitoribosome,FPLX,000288,Mitochondrial_Ribosome
+Mitoribosome,FPLX,000288,Mitochondrial_Ribosome
+55S mammalian mitochondrial ribosome,FPLX,000288,Mitochondrial_Ribosome
+55S mitoribosome,FPLX,000288,Mitochondrial_Ribosome
+55s mitoribosome,FPLX,000288,Mitochondrial_Ribosome
+55S Mitoribosome,FPLX,000288,Mitochondrial_Ribosome
+55s Mitoribosome,FPLX,000288,Mitochondrial_Ribosome
+small mitoribosomal subunit,FPLX,000289,MRPS
+Small Mitoribosomal Subunit,FPLX,000289,MRPS
+small subunit of the mammalian mitochondrial ribosome,FPLX,000289,MRPS
+mitochondrial ribosomal small subunit,FPLX,000289,MRPS
+large mitoribosomal subunit,FPLX,000290,MRPL
+Large Mitoribosomal Subunit,FPLX,000290,MRPL
+large subunit of the mammalian mitochondrial ribosome,FPLX,000290,MRPL
+MGAT,FPLX,000287,MGAT
+mitochondrial ribosomal large subunit,FPLX,000290,MRPL
+mitochondrial membrane potential,MESH,D053078,"Membrane Potential, Mitochondrial"
+mitogen activated protein kinase,FPLX,000283,MAPK
+mitogen activated protein kinases,FPLX,000283,MAPK
+mitogen-activated protein kinase kinase,FPLX,000281,MAP2K
+mitogen-activated protein kinase,FPLX,000283,MAPK
+mitogen-activated protein kinases,FPLX,000283,MAPK
+Miz1,UP,Q13105,ZBT17_HUMAN
+MKK4,UP,P45985,MP2K4_HUMAN
+MKP-1,UP,P28562,DUS1_HUMAN
+MKP3,UP,Q16828,DUS6_HUMAN
+MLC,FPLX,000296,MYL
+MM,MESH,D009101,Multiple Myeloma
+MMC,PUBCHEM,5746,
+MMC,CHEBI,CHEBI:27504,mitomycin C
+MMP,FPLX,000291,MMP
+MMP-2,UP,P08253,MMP2_HUMAN
+MMP-9,UP,P14780,MMP9_HUMAN
+MMP9,UP,P14780,MMP9_HUMAN
+MMPs,FPLX,000291,MMP
+Mn,CHEBI,CHEBI:29035,manganese(2+)
+Mn,PUBCHEM,27854,
+MST1,UP,Q13043,STK4_HUMAN
+MST2,UP,Q13188,STK3_HUMAN
+MT,FPLX,000292,Metallothionein
+mTOR inhibitor,CHEBI,CHEBI:68481,mTOR inhibitor
+mTOR inhibitors,CHEBI,CHEBI:68481,mTOR inhibitor
+mTOR,UP,P42345,MTOR_HUMAN
+mTORC1,FPLX,000293,mTORC1
+mTORC2,FPLX,000294,mTORC2
+MTX,UP,Q13505,MTX1_HUMAN
+Mu-A,PUBCHEM,375150,
+MUC1,UP,P15941,MUC1_HUMAN
+mutp53,UP,P04637,P53_HUMAN
+MYC,UP,P01106,MYC_HUMAN
+Myc,UP,P01106,MYC_HUMAN
+MYCN,UP,P04198,MYCN_HUMAN
+myosin alkali light chain proteins,FPLX,000297,MYL_alkali
+myosin alkali light chain,FPLX,000297,MYL_alkali
+myosin heavy chain genes,FPLX,000295,MYH
+myosin heavy chain isoforms,FPLX,000295,MYH
+myosin heavy chain protein,FPLX,000295,MYH
+Myosin heavy chain,FPLX,000295,MYH
+myosin heavy chain,FPLX,000295,MYH
+Myosin heavy chains,FPLX,000295,MYH
+myosin heavy chains,FPLX,000295,MYH
+myosin light chain protein,FPLX,000296,MYL
+myosin light chain,FPLX,000296,MYL
+myosin light chains,FPLX,000296,MYL
+MYPT1,UP,O14974,MYPT1_HUMAN
+MYST family,FPLX,000300,MYST
+MYST histone acetylase,FPLX,000300,MYST
+MYST proteins,FPLX,000300,MYST
+N-cadherin,UP,P19022,CADH2_HUMAN
+N-myc downstream regulated gene family,FPLX,000307,NDRG
+N-Myc,UP,P04198,MYCN_HUMAN
+N-Ras,UP,P01111,RASN_HUMAN
+Na+/K+-exchanging ATPase,FPLX,000303,Na_K_ATPase
+Na+/K+ATPase,FPLX,000303,Na_K_ATPase
+Na/K ATPase alpha,FPLX,000057,ATP1A
+Na/K ATPase α,FPLX,000057,ATP1A
+Na/K-ATPase,FPLX,000303,Na_K_ATPase
+NAC,PUBCHEM,443227,
+NAC,CHEBI,CHEBI:7421,NAC
+nAChR,FPLX,000103,CHRN
+NAD(P)H oxidase,FPLX,000302,NADPH_oxidase
+NAD(P)H-oxidase,FPLX,000302,NADPH_oxidase
+NADH dehydrogenase (ubiquinone),FPLX,000301,NADH_dehydrogenase
+NADH dehydrogenase,FPLX,000301,NADH_dehydrogenase
+NADPH oxidase,FPLX,000302,NADPH_oxidase
+NADPH,PUBCHEM,5884,
+NADPH,CHEBI,CHEBI:16474,NADPH
+NADPH,HMDB,HMDB00221,
+naked cuticle,FPLX,000315,NKD
+NAP,UP,P80723,BASP1_HUMAN
+Natriuretic Peptide,FPLX,000304,Natriuretic_peptide
+Natriuretic peptide,FPLX,000304,Natriuretic_peptide
+natriuretic peptide,FPLX,000304,Natriuretic_peptide
+Natriuretic Peptides,FPLX,000304,Natriuretic_peptide
+Natriuretic peptides,FPLX,000304,Natriuretic_peptide
+natriuretic peptides,FPLX,000304,Natriuretic_peptide
+NDR family,FPLX,000307,NDRG
+NDR-family,FPLX,000307,NDRG
+NDRG2,UP,Q9UN36,NDRG2_HUMAN
+necroptosis,GO,GO:0070266,necroptotic process
+necrosis,GO,GO:0070265,necrotic cell death
+necrosis,MESH,D009336,Necrosis
+Nef,UP,P03406,NEF_HV1BR
+NEMO,UP,Q9Y6K9,NEMO_HUMAN
+neovascularization,GO,GO:0001525,angiogenesis
+neovascularization,MESH,D018919,"Neovascularization, Physiologic"
+Net1,UP,Q7Z628,ARHG8_HUMAN
+neuregulin family,FPLX,000318,NRG
+Neuregulin,FPLX,000318,NRG
+neuregulin,FPLX,000318,NRG
+Neuregulins,FPLX,000318,NRG
+neuregulins,FPLX,000318,NRG
+Neurexins,FPLX,000308,Neurexins
+NF-E2,FPLX,000310,NFE
+NF-E2-related factor,FPLX,000310,NFE
+NF-kappaB Class 1,FPLX,000312,NFkappaB_1
+NF-kappaB class 1,FPLX,000312,NFkappaB_1
+NF-kappaB Class 2,FPLX,000313,NFkappaB_2
+NF-kappaB class 2,FPLX,000313,NFkappaB_2
+NF-kappaB Class I,FPLX,000312,NFkappaB_1
+NF-kappaB class I,FPLX,000312,NFkappaB_1
+NF-kappaB Class II,FPLX,000313,NFkappaB_2
+NF-kappaB class II,FPLX,000313,NFkappaB_2
+NF-kappaB complexes,FPLX,000311,NFkappaB
+NF-kappaB dimers,FPLX,000311,NFkappaB
+NF-kappaB Factors,FPLX,000311,NFkappaB
+NF-kappaB factors,FPLX,000311,NFkappaB
+NF-kappaB genes,FPLX,000311,NFkappaB
+NF-kappaB p50,HGNC,7794,NFKB1
+NF-kappaB p65,HGNC,9955,RELA
+NF-kappaB p65,UP,Q04206,TF65_HUMAN
+NF-kappaB subunits,FPLX,000311,NFkappaB
+NF-kappaB TFs,FPLX,000311,NFkappaB
+NF-kappaB,FPLX,000311,NFkappaB
+NF-kappaB1,HGNC,7794,NFKB1
+NF-kappaB2,HGNC,7795,NFKB2
+NF-kappabeta,FPLX,000311,NFkappaB
+NF-kappaBp50,HGNC,7794,NFKB1
+NF-kappaBp65,HGNC,9955,RELA
+NF-kappaBs,FPLX,000311,NFkappaB
+NF-kB,FPLX,000311,NFkappaB
+NF-Y,FPLX,000314,NFY
+NF-κB Class 1,FPLX,000312,NFkappaB_1
+NF-κB class 1,FPLX,000312,NFkappaB_1
+NF-κB Class 2,FPLX,000313,NFkappaB_2
+NF-κB class 2,FPLX,000313,NFkappaB_2
+NF-κB Class I,FPLX,000312,NFkappaB_1
+NF-κB class I,FPLX,000312,NFkappaB_1
+NF-κB Class II,FPLX,000313,NFkappaB_2
+NF-κB class II,FPLX,000313,NFkappaB_2
+NF-κB complexes,FPLX,000311,NFkappaB
+NF-κB dimers,FPLX,000311,NFkappaB
+NF-κB Factors,FPLX,000311,NFkappaB
+NF-κB factors,FPLX,000311,NFkappaB
+NF-κB genes,FPLX,000311,NFkappaB
+NF-κB p50,HGNC,7794,NFKB1
+NF-κB p65,HGNC,9955,RELA
+NF-κB p65,UP,Q04206,TF65_HUMAN
+NF-κB subunits,FPLX,000311,NFkappaB
+NF-κB TFs,FPLX,000311,NFkappaB
+NF-κB,FPLX,000311,NFkappaB
+NF-κB1,HGNC,7794,NFKB1
+NF-κB2,HGNC,7795,NFKB2
+NF-κBp50,HGNC,7794,NFKB1
+NF-κBp65,HGNC,9955,RELA
+NF-κBs,FPLX,000311,NFkappaB
+NF-κβ,FPLX,000311,NFkappaB
+NFAT,FPLX,000309,NFAT
+NFkappaB complexes,FPLX,000311,NFkappaB
+NFkappaB p50,HGNC,7794,NFKB1
+NFkappaB p65,HGNC,9955,RELA
+NFkappaB,FPLX,000311,NFkappaB
+NFkappaBp65,HGNC,9955,RELA
+NFY,FPLX,000314,NFY
+NFκB complexes,FPLX,000311,NFkappaB
+NFκB p50,HGNC,7794,NFKB1
+NFκB p65,HGNC,9955,RELA
+NFκB,FPLX,000311,NFkappaB
+NFκBp65,HGNC,9955,RELA
+NGF,UP,P01138,NGF_HUMAN
+nicotine class acetylcholine receptors,FPLX,000103,CHRN
+nicotinic acetylcholine receptor,FPLX,000103,CHRN
+nitric oxide,PUBCHEM,145068,
+nitric oxide,CHEBI,CHEBI:16480,nitric oxide
+nmMLCK,UP,Q15746-1,MYLK_HUMAN
+nmMLCK1,UP,Q15746-1,MYLK_HUMAN
+NO,HMDB,HMDB03378,
+NO,CHEBI,CHEBI:16480,nitric oxide
+NO,PUBCHEM,145068,
+non-ELR-CXC chemokines,FPLX,000128,CXCL_ELR_negative
+NOS,FPLX,000316,NOS
+Notch,FPLX,000317,Notch
+Notch1,UP,P46531,NOTC1_HUMAN
+NOX1,UP,Q9Y5S8,NOX1_HUMAN
+NOX2,UP,P04839,CY24B_HUMAN
+NOX3,UP,Q9HBY0,NOX3_HUMAN
+NOX4,UP,Q9NPH5,NOX4_HUMAN
+Noxa,UP,Q13794,APR_HUMAN
+NPM,UP,P06748,NPM_HUMAN
+NRAS,UP,P01111,RASN_HUMAN
+NRF2,UP,Q16236,NF2L2_HUMAN
+Nrf2,UP,Q16236,NF2L2_HUMAN
+NRG1,UP,Q02297,NRG1_HUMAN
+NRG1-NRG2,FPLX,000319,NRG_1_2
+NRG1/2,FPLX,000319,NRG_1_2
+NRG3-NRG4,FPLX,000320,NRG_3_4
+NRG3/4,FPLX,000320,NRG_3_4
+NRGs,FPLX,000318,NRG
+NRXN,FPLX,000308,Neurexins
+NTF3,UP,P20783,NTF3_HUMAN
+NTRK,FPLX,000321,NTRK
+NTRKs,FPLX,000321,NTRK
+Nuclear factor erythroid 2-related factor,FPLX,000310,NFE
+nuclear factor Y,FPLX,000314,NFY
+nuclear factor-Y,FPLX,000314,NFY
+Nuclear Receptor Co-Repressor,FPLX,000306,NCOR
+nuclear receptor co-repressor,FPLX,000306,NCOR
+Nuclear receptor corepressor,FPLX,000306,NCOR
+nuclear receptor corepressor,FPLX,000306,NCOR
+Nutlin-3,PUBCHEM,16755649,
+Nutlin-3,CHEBI,CHEBI:46742,Nutlin-3
+NVP-BEZ235,PUBCHEM,11977753,
+NVP-BEZ235,LINCS,10232-101,
+NVP-BEZ235,CHEBI,CHEBI:71952,dactolisib
+NVP-LDE-225,PUBCHEM,24775005,
+NVP-LDE-225,CHEBI,CHEBI:90863,sonidegib
+OA,CHEBI,CHEBI:37659,oleanolic acid
+OA,PUBCHEM,10494,
+OA,CHEBI,CHEBI:44658,okadaic acid
+OA,PUBCHEM,446512,
+ofalpha(2)-adrenoceptor,FPLX,000020,ADRA2
+ofα(2)-adrenoceptor,FPLX,000020,ADRA2
+OPG,UP,O00300,TR11B_HUMAN
+OPN,UP,P10451,OSTP_HUMAN
+ov-serpins,FPLX,000431,SERPINB
+oxaliplatin,CHEBI,CHEBI:31941,oxaliplatin
+oxaliplatin,PUBCHEM,6857599,
+oxygen,HMDB,HMDB01377,
+oxygen,CHEBI,CHEBI:15379,dioxygen
+oxygen,PUBCHEM,977,
+P-REX1,UP,Q8TCU6,PREX1_HUMAN
+p100,HGNC,7795,NFKB2
+p105,HGNC,7794,NFKB1
+p110,FPLX,000359,PI3K_p110
+p110alpha,UP,P42336,PK3CA_HUMAN
+p110beta,UP,P42338,PK3CB_HUMAN
+p110α,UP,P42336,PK3CA_HUMAN
+p110β,UP,P42338,PK3CB_HUMAN
+p120,UP,O60716,CTND1_HUMAN
+p130,UP,P56945,BCAR1_HUMAN
+p16,UP,P42771,CDN2A_HUMAN
+p160/SRC,FPLX,000305,NCOA
+p21 Cip1,UP,P38936,CDN1A_HUMAN
+p21 WAF1,UP,P38936,CDN1A_HUMAN
+p21,UP,P38936,CDN1A_HUMAN
+p22 phox,UP,P13498,CY24A_HUMAN
+p27 Kip1,UP,P46527,CDN1B_HUMAN
+p27,UP,P46527,CDN1B_HUMAN
+P2X purinoreceptor,FPLX,000324,P2RX
+P2X purinoreceptors,FPLX,000324,P2RX
+P2X receptor,FPLX,000324,P2RX
+P2X receptors,FPLX,000324,P2RX
+P2X,FPLX,000324,P2RX
+P2Y receptor,FPLX,000325,P2RY
+p300,UP,Q09472,EP300_HUMAN
+P38 MAPK,FPLX,000326,p38
+p38 MAPK,FPLX,000326,p38
+p38 MAPKs,FPLX,000326,p38
+p38,FPLX,000326,p38
+p38-MAPK,FPLX,000326,p38
+p38MAPK,FPLX,000326,p38
+p40 phox,UP,Q15080,NCF4_HUMAN
+p42,UP,P28482,MK01_HUMAN
+p42,UP,Q9UQ80,PA2G4_HUMAN
+p47 phox,UP,P14598,NCF1_HUMAN
+p50,UP,P19838,NFKB1_HUMAN
+p52,HGNC,7795,NFKB2
+P53 family,FPLX,000327,p53_family
+p53 Family,FPLX,000327,p53_family
+p53 family,FPLX,000327,p53_family
+P53,UP,P04637,P53_HUMAN
+p53,UP,P04637,P53_HUMAN
+p53/p63/p73 family,FPLX,000327,p53_family
+p62,UP,Q13501,SQSTM_HUMAN
+p63,UP,Q9H3D4,P63_HUMAN
+p65,UP,Q04206,TF65_HUMAN
+p66Shc,UP,P29353-1,SHC1_HUMAN
+p67 phox,UP,P19878,NCF2_HUMAN
+p70 S6 kinase,FPLX,000328,P70S6K
+p70,UP,P23443,KS6B1_HUMAN
+P70RSK,FPLX,000328,P70S6K
+p70RSK,FPLX,000328,P70S6K
+p70S6 kinase,UP,P23443,KS6B1_HUMAN
+P70S6K,FPLX,000328,P70S6K
+p70S6K,UP,P23443,KS6B1_HUMAN
+p73,UP,O15350,P73_HUMAN
+p85,FPLX,000360,PI3K_p85
+p85alpha,UP,P27986,P85A_HUMAN
+p85α,UP,P27986,P85A_HUMAN
+p90RSK,FPLX,000329,P90RSK
+PA,CHEBI,CHEBI:16337,phosphatidic acid
+PA,PUBCHEM,8144759,
+paeoniflorin,CHEBI,CHEBI:7889,paeoniflorin
+paeoniflorin,PUBCHEM,442534,
+PAI-1,UP,P05121,PAI1_HUMAN
+PAK,FPLX,000330,PAK
+Pak,FPLX,000330,PAK
+PAK1,UP,Q13153,PAK1_HUMAN
+Pak1,UP,Q13153,PAK1_HUMAN
+Pak2,UP,Q13177,PAK2_HUMAN
+PAK4,UP,O96013,PAK4_HUMAN
+palmitate,PUBCHEM,985,
+palmitate,CHEBI,CHEBI:15756,hexadecanoic acid
+palmitate,HMDB,HMDB00220,
+PAR3,UP,Q8TEW0,PARD3_HUMAN
+Parkin,UP,O60260,PRKN_HUMAN
+PARP genes,FPLX,000331,PARP
+PARP,UP,P09874,PARP1_HUMAN
+Parp,UP,P09874,PARP1_HUMAN
+PARP-1,UP,P09874,PARP1_HUMAN
+PARPs,FPLX,000331,PARP
+Parvin,FPLX,000332,PARV
+parvin,FPLX,000332,PARV
+Parvins,FPLX,000332,PARV
+parvins,FPLX,000332,PARV
+PATCHED,FPLX,000333,Patched
+Patched,FPLX,000333,Patched
+paxillin,UP,P49023,PAXI_HUMAN
+PBX,FPLX,000334,PBX
+Pbx,FPLX,000334,PBX
+pbx,FPLX,000334,PBX
+PBXs,FPLX,000334,PBX
+Pca,MESH,D011471,Prostatic Neoplasms
+PCNA,UP,P12004,PCNA_HUMAN
+PD,MESH,D010300,Parkinson Disease
+PD98509,CHEBI,CHEBI:79091,EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
+PDE 2,HGNC,8777,PDE2A
+PDE 3,FPLX,000337,PDE3
+PDE,FPLX,000335,PDE
+PDE1 family,FPLX,000336,PDE1
+PDE1,FPLX,000336,PDE1
+PDE3 family,FPLX,000337,PDE3
+PDE3,FPLX,000337,PDE3
+PDE4 family,FPLX,000338,PDE4
+PDE4 isoforms,FPLX,000338,PDE4
+PDE4,FPLX,000338,PDE4
+PDE5,HGNC,8784,PDE5A
+PDE6 family,FPLX,000339,PDE6
+PDE6,FPLX,000339,PDE6
+PDE7,FPLX,000340,PDE7
+PDE8,FPLX,000341,PDE8
+PDEs,FPLX,000335,PDE
+PDGF CC,FPLX,000350,PDGF_CC
+PDGF DD,FPLX,000351,PDGF_DD
+PDGF,FPLX,000342,PDGF
+PDGF-AA,FPLX,000347,PDGF_AA
+PDGF-aa,FPLX,000347,PDGF_AA
+PDGF-AB,FPLX,000348,PDGF_AB
+PDGF-ab,FPLX,000348,PDGF_AB
+PDGF-BB,FPLX,000349,PDGF_BB
+PDGF-bb,FPLX,000349,PDGF_BB
+PDGF-CC,FPLX,000350,PDGF_CC
+PDGF-cc,FPLX,000350,PDGF_CC
+PDGF-DD,FPLX,000351,PDGF_DD
+PDGF-dd,FPLX,000351,PDGF_DD
+PDGFAA,FPLX,000347,PDGF_AA
+PDGFAB,FPLX,000348,PDGF_AB
+PDGFBB,FPLX,000349,PDGF_BB
+PDGFR,FPLX,000343,PDGFR
+PDGFR-AA,FPLX,000344,PDGFR_AA
+PDGFR-AB,FPLX,000345,PDGFR_AB
+PDGFR-alphaalpha,FPLX,000344,PDGFR_AA
+PDGFR-alphabeta,FPLX,000345,PDGFR_AB
+PDGFR-BB,FPLX,000346,PDGFR_BB
+PDGFR-betabeta,FPLX,000346,PDGFR_BB
+PDGFR-αα,FPLX,000344,PDGFR_AA
+PDGFR-αβ,FPLX,000345,PDGFR_AB
+PDGFR-ββ,FPLX,000346,PDGFR_BB
+PDGFRalpha,UP,P16234,PGFRA_HUMAN
+PDGFRalphaalpha,FPLX,000344,PDGFR_AA
+PDGFRalphabeta,FPLX,000345,PDGFR_AB
+PDGFRbeta,UP,P09619,PGFRB_HUMAN
+PDGFRbetabeta,FPLX,000346,PDGFR_BB
+PDGFRβ,UP,P09619,PGFRB_HUMAN
+PDGFRα,UP,P16234,PGFRA_HUMAN
+PDGFRαα,FPLX,000344,PDGFR_AA
+PDGFRαβ,FPLX,000345,PDGFR_AB
+PDGFRββ,FPLX,000346,PDGFR_BB
+PDH,FPLX,000352,PDH
+PDK,FPLX,000353,PDK
+PDK,UP,O15530,PDPK1_HUMAN
+PDK1,UP,O15530,PDPK1_HUMAN
+PDKs,FPLX,000353,PDK
+PDPK1,UP,O15530,PDPK1_HUMAN
+PDT,MESH,D010778,Photochemotherapy
+PEA-15,UP,Q15121,PEA15_HUMAN
+PERK,UP,Q9NZJ5,E2AK3_HUMAN
+Peroxiredoxin,FPLX,000388,PRDX
+peroxiredoxin,FPLX,000388,PRDX
+Peroxiredoxins,FPLX,000388,PRDX
+peroxiredoxins,FPLX,000388,PRDX
+Pertussis toxin,FPLX,000354,Pertussis_toxin
+pertussis toxin,FPLX,000354,Pertussis_toxin
+PF-3758309,PUBCHEM,25227462,
+PF-3758309,CHEBI,CHEBI:93751,"N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide"
+PGC-1alpha,UP,Q9UBK2,PRGC1_HUMAN
+PGC-1α,UP,Q9UBK2,PRGC1_HUMAN
+PGE 2,CHEBI,CHEBI:73965,prostaglandin E2-UM
+PGE 2,PUBCHEM,161468,
+PGE2,UP,P35408,PE2R4_HUMAN
+phenformin,PUBCHEM,8249,
+phenformin,CHEBI,CHEBI:8064,phenformin
+PhK,FPLX,000356,PhK
+phosphatase,FPLX,000357,Phosphatase
+phosphatidylinositol 3-kinase,FPLX,000358,PI3K
+phosphatidylinositol,CHEBI,CHEBI:28874,phosphatidylinositol
+phosphatidylinositol,MESH,D010716,Phosphatidylinositols
+phospho-ERK1/2,FPLX,000161,ERK
+Phosphodiesterase 1,FPLX,000336,PDE1
+phosphodiesterase 1,FPLX,000336,PDE1
+Phosphodiesterase 2,HGNC,8777,PDE2A
+phosphodiesterase 2,HGNC,8777,PDE2A
+Phosphodiesterase 3,FPLX,000337,PDE3
+phosphodiesterase 3,FPLX,000337,PDE3
+Phosphodiesterase 4,FPLX,000338,PDE4
+phosphodiesterase 4,FPLX,000338,PDE4
+Phosphodiesterase 5,HGNC,8784,PDE5A
+phosphodiesterase 5,HGNC,8784,PDE5A
+Phosphodiesterase 6,FPLX,000339,PDE6
+phosphodiesterase 6,FPLX,000339,PDE6
+Phosphodiesterase 7,FPLX,000340,PDE7
+phosphodiesterase 7,FPLX,000340,PDE7
+Phosphodiesterase 8,FPLX,000341,PDE8
+phosphodiesterase 8,FPLX,000341,PDE8
+Phosphodiesterase,FPLX,000335,PDE
+phosphodiesterase,FPLX,000335,PDE
+Phosphodiesterase-1,FPLX,000336,PDE1
+phosphodiesterase-1,FPLX,000336,PDE1
+Phosphodiesterase-2,HGNC,8777,PDE2A
+phosphodiesterase-2,HGNC,8777,PDE2A
+Phosphodiesterase-3,FPLX,000337,PDE3
+phosphodiesterase-3,FPLX,000337,PDE3
+Phosphodiesterase-4,FPLX,000338,PDE4
+phosphodiesterase-4,FPLX,000338,PDE4
+Phosphodiesterase-5,HGNC,8784,PDE5A
+phosphodiesterase-5,HGNC,8784,PDE5A
+Phosphodiesterase-6,FPLX,000339,PDE6
+phosphodiesterase-6,FPLX,000339,PDE6
+Phosphodiesterase-7,FPLX,000340,PDE7
+phosphodiesterase-7,FPLX,000340,PDE7
+Phosphodiesterase-8,FPLX,000341,PDE8
+phosphodiesterase-8,FPLX,000341,PDE8
+Phosphodiesterases,FPLX,000335,PDE
+phosphodiesterases,FPLX,000335,PDE
+Phospholipase A2 Group IV,FPLX,000368,PLA2G4
+phospholipase A2 group-II,FPLX,000367,PLA2G2
+phospholipase A2 group-IV,FPLX,000368,PLA2G4
+phospholipase A2,FPLX,000366,PLA2
+Phospholipase C,FPLX,000369,PLC
+phospholipase C,FPLX,000369,PLC
+Phospholipase C-beta,FPLX,000370,PLCB
+phospholipase C-beta,FPLX,000370,PLCB
+Phospholipase C-delta,FPLX,000371,PLCD
+phospholipase C-delta,FPLX,000371,PLCD
+Phospholipase C-β,FPLX,000370,PLCB
+phospholipase C-β,FPLX,000370,PLCB
+Phospholipase C-δ,FPLX,000371,PLCD
+phospholipase C-δ,FPLX,000371,PLCD
+Phospholipase Cbeta,FPLX,000370,PLCB
+phospholipase Cbeta,FPLX,000370,PLCB
+Phospholipase Cdelta,FPLX,000371,PLCD
+phospholipase Cdelta,FPLX,000371,PLCD
+Phospholipase Cβ,FPLX,000370,PLCB
+phospholipase Cβ,FPLX,000370,PLCB
+Phospholipase Cδ,FPLX,000371,PLCD
+phospholipase Cδ,FPLX,000371,PLCD
+Phospholipase D,FPLX,000373,PLD
+phospholipase D,FPLX,000373,PLD
+Phospholipase-C,FPLX,000369,PLC
+phospholipase-C,FPLX,000369,PLC
+Phosphorylase kinase,FPLX,000356,PhK
+phosphorylase kinase,FPLX,000356,PhK
+PI 3-kinase,FPLX,000358,PI3K
+PI 3-kinases,FPLX,000358,PI3K
+PI,CHEBI,CHEBI:28874,phosphatidylinositol
+PI,MESH,D010716,Phosphatidylinositols
+PI3-kinase,FPLX,000358,PI3K
+PI3K inhibitor,CHEBI,CHEBI:84801,EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor
+PI3K p110 subunit,FPLX,000359,PI3K_p110
+PI3K,FPLX,000358,PI3K
+PI3Kinase,FPLX,000358,PI3K
+PIK3C,FPLX,000359,PI3K_p110
+PIK3CA,UP,P42336,PK3CA_HUMAN
+PIK3R,FPLX,000361,PIK3R_I
+PIM,FPLX,000362,PIM
+Pin1,UP,Q13526,PIN1_HUMAN
+PIP,CHEBI,CHEBI:28765,phosphatidylinositol phosphate
+PIP3,MESH,C060974,"phosphatidylinositol 3,4,5-triphosphate"
+PIP3,CHEBI,CHEBI:60169,phosphatidylinositol trisphosphate
+PK-A,FPLX,000363,PKA
+PKA catalytic subunit,FPLX,000389,PRKAC
+PKA catalytic subunits,FPLX,000389,PRKAC
+PKA regulatory subunit,FPLX,000390,PRKAR
+PKA regulatory subunits,FPLX,000390,PRKAR
+PKA,FPLX,000363,PKA
+PKB,FPLX,000023,AKT
+PKB-Akt,FPLX,000023,AKT
+PKB/Akt,FPLX,000023,AKT
+PKC,FPLX,000364,PKC
+PKCalpha,UP,P17252,KPCA_HUMAN
+PKCdelta,UP,Q05655,KPCD_HUMAN
+PKCepsilon,UP,Q02156,KPCE_HUMAN
+PKCα,UP,P17252,KPCA_HUMAN
+PKCε,UP,Q02156,KPCE_HUMAN
+PKCδ,UP,Q05655,KPCD_HUMAN
+PKG,FPLX,000391,PRKG
+PKI,FPLX,000365,PKI
+PKM2,UP,P14618,KPYM_HUMAN
+PKR,UP,P19525,E2AK2_HUMAN
+PLA2G2,FPLX,000367,PLA2G2
+PLA2g2,FPLX,000367,PLA2G2
+PLA2G4,FPLX,000368,PLA2G4
+PLB,UP,P26678,PPLA_HUMAN
+PLC,FPLX,000369,PLC
+PLC-gamma,FPLX,000372,PLCG
+PLC-gamma1,UP,P19174,PLCG1_HUMAN
+PLC-γ,FPLX,000372,PLCG
+PLC-γ1,UP,P19174,PLCG1_HUMAN
+PLCgamma1,UP,P19174,PLCG1_HUMAN
+PLCγ1,UP,P19174,PLCG1_HUMAN
+PLK1,UP,P53350,PLK1_HUMAN
+Plk1,UP,P53350,PLK1_HUMAN
+PLX,PUBCHEM,42611257,
+PLX,CHEBI,CHEBI:63637,vemurafenib
+PLX4032,PUBCHEM,42611257,
+PLX4032,CHEBI,CHEBI:63637,vemurafenib
+PML,UP,P29590,PML_HUMAN
+Pol delta,FPLX,000141,DNA_polymerase_delta
+pol delta,FPLX,000141,DNA_polymerase_delta
+Pol I,FPLX,000416,RNApo_I
+Pol δ,FPLX,000141,DNA_polymerase_delta
+pol δ,FPLX,000141,DNA_polymerase_delta
+Poly(ADP-ribose) polymerase,FPLX,000331,PARP
+Poly(ADP-ribose) polymerases,FPLX,000331,PARP
+polycomb Repressive Complex (PRC) 1,FPLX,000386,PRC1_complex
+Polycomb Repressive Complex 1,FPLX,000386,PRC1_complex
+Polycomb repressive complex 1,FPLX,000386,PRC1_complex
+polycomb repressive complex 1,FPLX,000386,PRC1_complex
+Polycomb Repressive Complex 2,FPLX,000387,PRC2_complex
+Polycomb repressive complex 2,FPLX,000387,PRC2_complex
+polycomb repressive complex 2,FPLX,000387,PRC2_complex
+Polycomb repressive complex PRC1,FPLX,000386,PRC1_complex
+Polycomb repressive complex PRC2,FPLX,000387,PRC2_complex
+Polycomb Repressive Complexes 1,FPLX,000386,PRC1_complex
+Polycomb Repressive Complexes 2,FPLX,000387,PRC2_complex
+Polycomb-repressive complex 1,FPLX,000386,PRC1_complex
+Polycomb-repressive complex 2,FPLX,000387,PRC2_complex
+PP1 regulator,FPLX,000376,PPP1
+PP1,FPLX,000376,PPP1
+PP1C,FPLX,000377,PPP1C
+PP1c,FPLX,000377,PPP1C
+PP1R,FPLX,000378,PPP1R
+PP1r,FPLX,000378,PPP1R
+PP2 phosphatases,FPLX,000379,PPP2
+PP2,CHEBI,CHEBI:78331,PP2
+PP2,PUBCHEM,4878,
+PP2,FPLX,000379,PPP2
+PP242,PUBCHEM,135565635,
+PP242,CHEBI,CHEBI:90679,torkinib
+PP2A catalytic C subunit,FPLX,000380,PPP2C
+PP2A regulatory subunit A,FPLX,000381,PPP2R_A
+PP2A regulatory subunit B,FPLX,000382,PPP2R_B
+PP2A,FPLX,000379,PPP2
+PP2A-C,FPLX,000380,PPP2C
+PP2Ac,FPLX,000380,PPP2C
+PP2B catalytic subunit,FPLX,000384,PPP3C
+PP2B,FPLX,000383,PPP3
+PPAR,FPLX,000375,PPAR
+PPAR-gamma,UP,P37231,PPARG_HUMAN
+PPAR-γ,UP,P37231,PPARG_HUMAN
+PPARgamma,UP,P37231,PPARG_HUMAN
+PPARγ,UP,P37231,PPARG_HUMAN
+PPP1,FPLX,000376,PPP1
+PPP1C,FPLX,000377,PPP1C
+PR,UP,P06401,PRGR_HUMAN
+PRAS40,UP,Q96B36,AKTS1_HUMAN
+pRB,UP,P06400,RB_HUMAN
+pRb,UP,P06400,RB_HUMAN
+PRC1,FPLX,000386,PRC1_complex
+PRC1,UP,O43663,PRC1_HUMAN
+PRC2,FPLX,000387,PRC2_complex
+PRKAA,FPLX,000044,AMPK_alpha
+PRKAB,FPLX,000045,AMPK_beta
+PRKAG,FPLX,000046,AMPK_gamma
+PRL-3,UP,O75365,TP4A3_HUMAN
+Profilin,FPLX,000355,PFN
+profilin,FPLX,000355,PFN
+Profilins,FPLX,000355,PFN
+profilins,FPLX,000355,PFN
+progesterone,CHEBI,CHEBI:17026,progesterone
+progesterone,PUBCHEM,5994,
+Proliferation,GO,GO:0008283,cell population proliferation
+Proliferation,MESH,D049109,Cell Proliferation
+proliferation,GO,GO:0008283,cell population proliferation
+proliferation,MESH,D049109,Cell Proliferation
+Propionyl-CoA carboxylase,FPLX,000392,Propionyl_CoA_carboxylase
+propionyl-CoA carboxylase,FPLX,000392,Propionyl_CoA_carboxylase
+prostaglandin E receptor,FPLX,000395,PTGER
+protease,FPLX,000393,Protease
+proteasome endopeptidase,FPLX,000394,Proteasome
+proteasome,FPLX,000394,Proteasome
+protein farnesyltransferase,FPLX,000172,FNT
+Protein kinase A catalytic subunit,FPLX,000389,PRKAC
+protein kinase A catalytic subunit,FPLX,000389,PRKAC
+Protein kinase A catalytic subunits,FPLX,000389,PRKAC
+protein kinase A catalytic subunits,FPLX,000389,PRKAC
+Protein kinase A regulatory subunit,FPLX,000390,PRKAR
+protein kinase A regulatory subunit,FPLX,000390,PRKAR
+Protein kinase A regulatory subunits,FPLX,000390,PRKAR
+protein kinase A regulatory subunits,FPLX,000390,PRKAR
+protein kinase A,FPLX,000363,PKA
+protein kinase C,FPLX,000364,PKC
+protein kinase G,FPLX,000391,PRKG
+protein phosphatase 2,FPLX,000379,PPP2
+protein phosphatase 2B,FPLX,000383,PPP3
+proteolysis,GO,GO:0006508,proteolysis
+proteolysis,MESH,D059748,Proteolysis
+PTC,UP,P18502,PTC_DROME
+Ptc,UP,P18502,PTC_DROME
+ptc,UP,P18502,PTC_DROME
+PTEN,UP,P60484,PTEN_HUMAN
+Pten,UP,P60484,PTEN_HUMAN
+PTP1B,UP,P18031,PTN1_HUMAN
+PTX,FPLX,000354,Pertussis_toxin
+PTX3,HGNC,9692,PTX3
+PTX3,UP,P26022,PTX3_HUMAN
+PUMA,UP,Q96PG8,BBC3B_HUMAN
+PYG,FPLX,000396,PYG
+Pyk2,UP,Q14289,FAK2_HUMAN
+pyruvate dehydrogenase (acetyl-transferring),FPLX,000352,PDH
+Pyruvate dehydrogenase kinase,FPLX,000353,PDK
+pyruvate dehydrogenase kinase,FPLX,000353,PDK
+quercetin,CHEBI,CHEBI:16243,quercetin
+quercetin,PUBCHEM,5280343,
+RA,PUBCHEM,5538,
+RA,CHEBI,CHEBI:26536,retinoic acid
+RA,HMDB,HMDB06219,
+Rab GTPase,FPLX,000397,RAB
+Rab GTPases,FPLX,000397,RAB
+rab GTPases,FPLX,000397,RAB
+rab proteins,FPLX,000397,RAB
+RAB,FPLX,000397,RAB
+Rab,FPLX,000397,RAB
+rab,FPLX,000397,RAB
+Rabs,FPLX,000397,RAB
+RAC,FPLX,000398,RAC
+Rac,UP,P63000,RAC1_HUMAN
+RAC1,UP,P63000,RAC1_HUMAN
+Rac1,UP,P63000,RAC1_HUMAN
+RAD51,UP,Q06609,RAD51_HUMAN
+Rad51,UP,Q06609,RAD51_HUMAN
+Rad52,UP,P43351,RAD52_HUMAN
+RAF inhibitors,CHEBI,CHEBI:75047,B-Raf inhibitor
+RAF,FPLX,000399,RAF
+Raf,FPLX,000399,RAF
+Raf-1,UP,P04049,RAF1_HUMAN
+RAGE,UP,Q15109,RAGE_HUMAN
+RAL family,FPLX,000400,RAL
+Ral family,FPLX,000400,RAL
+RAL guanine nucleotide dissociation stimulator like,FPLX,000413,RGL
+Ral guanine nucleotide dissociation stimulator like,FPLX,000413,RGL
+ral guanine nucleotide dissociation stimulator like,FPLX,000413,RGL
+RAL isoforms,FPLX,000400,RAL
+Ral isoforms,FPLX,000400,RAL
+RAL proteins,FPLX,000400,RAL
+Ral proteins,FPLX,000400,RAL
+RAL,FPLX,000400,RAL
+RAL,HGNC,9839,RALA
+RalA,UP,P11233,RALA_HUMAN
+RALGDS-like,FPLX,000413,RGL
+RANKL,UP,O14788,TNF11_HUMAN
+Rap guanine nucleotide exchange factor,FPLX,000402,RAPGEF
+Rap guanine nucleotide exchange factors,FPLX,000402,RAPGEF
+Rap1,FPLX,000401,RAP1
+Rapamycin,PUBCHEM,5284616,
+Rapamycin,CHEBI,CHEBI:9168,sirolimus
+rapamycin,PUBCHEM,5284616,
+rapamycin,CHEBI,CHEBI:9168,sirolimus
+RapGEFs,FPLX,000402,RAPGEF
+Raptor,UP,Q8N122,RPTOR_HUMAN
+raptor,UP,Q8N122,RPTOR_HUMAN
+RAR,FPLX,000403,RAR
+RAS association domain family,FPLX,000410,RASSF
+Ras association domain family,FPLX,000410,RASSF
+Ras GTPase,FPLX,000404,RAS
+RAS,FPLX,000404,RAS
+Ras,FPLX,000404,RAS
+RAS-association domain family,FPLX,000410,RASSF
+Ras-association domain family,FPLX,000410,RASSF
+RASA,FPLX,000405,RASA
+RASAL,FPLX,000406,RASAL
+RasGAP,FPLX,000407,RasGAP
+RasGAPs,FPLX,000407,RasGAP
+RASGRF,FPLX,000408,RASGRF
+RASGRP,FPLX,000409,RASGRP
+RASSF family,FPLX,000410,RASSF
+RASSF1A,UP,Q9NS23,RASF1_HUMAN
+RB,UP,P06400,RB_HUMAN
+Rb,UP,P06400,RB_HUMAN
+RB1,UP,P06400,RB_HUMAN
+Rb1,UP,P06400,RB_HUMAN
+receptor tyrosine kinase-like orphan receptor,FPLX,000420,ROR
+receptor tyrosine kinase-like orphan receptors,FPLX,000420,ROR
+REDD1,UP,Q9NX09,DDIT4_HUMAN
+regulatory A subunit of PP2A,FPLX,000381,PPP2R_A
+regulatory B subunit of PP2A,FPLX,000382,PPP2R_B
+regulatory family X,FPLX,000412,RFX
+regulatory myosin light chain,FPLX,000298,MYL_regulatory
+regulatory subunit of calcineurin,FPLX,000385,PPP3R
+RelA,UP,Q04206,TF65_HUMAN
+replication factor C,FPLX,000411,RFC
+Replication protein A,FPLX,000421,RPA
+replication protein A,FPLX,000421,RPA
+RES,PUBCHEM,5281611,
+Resveratrol,PUBCHEM,445154,
+Resveratrol,CHEBI,CHEBI:27881,resveratrol
+resveratrol,PUBCHEM,445154,
+resveratrol,CHEBI,CHEBI:27881,resveratrol
+RET,UP,P07949,RET_HUMAN
+retinoblastoma protein,UP,P06400,RB_HUMAN
+retinoic acid receptors,FPLX,000403,RAR
+retinoid X receptors,FPLX,000424,RXR
+retinoid-X receptor,FPLX,000424,RXR
+RF-C,FPLX,000411,RFC
+RF-X,FPLX,000412,RFX
+RFC,FPLX,000411,RFC
+RFX family,FPLX,000412,RFX
+RFX proteins,FPLX,000412,RFX
+RFX,FPLX,000412,RFX
+Rheb,UP,Q15382,RHEB_HUMAN
+Rho family,FPLX,000414,RHO
+RHO,FPLX,000414,RHO
+Rho,UP,P61586,RHOA_HUMAN
+Rho-GDI,FPLX,000415,RhoGDI
+RhoA,UP,P61586,RHOA_HUMAN
+RhoB,UP,P62745,RHOB_HUMAN
+RhoC,UP,P08134,RHOC_HUMAN
+RHOGDI,FPLX,000415,RhoGDI
+RhoGDI,FPLX,000415,RhoGDI
+rhoGDI,FPLX,000415,RhoGDI
+RhoGDIs,FPLX,000415,RhoGDI
+ribosomal protein S6,UP,P62753,RS6_HUMAN
+ribosomal protein S6,IP,IPR000529,
+RICTOR,UP,Q6R327,RICTR_HUMAN
+Rictor,UP,Q6R327,RICTR_HUMAN
+RIG-I,UP,O95786,DDX58_HUMAN
+RIP1,UP,Q13546,RIPK1_HUMAN
+RKIP,UP,P30086,PEBP1_HUMAN
+RNA polymerase 1,FPLX,000416,RNApo_I
+RNA polymerase I,FPLX,000416,RNApo_I
+RNA polymerase II,FPLX,000417,RNApo_II
+RNAP II,FPLX,000417,RNApo_II
+ROCK,FPLX,000419,ROCK
+ROCK1,UP,Q13464,ROCK1_HUMAN
+ROCK2,UP,O75116,ROCK2_HUMAN
+ROR,FPLX,000420,ROR
+RORs,FPLX,000420,ROR
+ROS,MESH,D017382,Reactive Oxygen Species
+ROS,UP,P08922,ROS1_HUMAN
+rosiglitazone,CHEBI,CHEBI:50122,rosiglitazone
+rosiglitazone,PUBCHEM,77999,
+rottlerin,CHEBI,CHEBI:8899,rottlerin
+rottlerin,PUBCHEM,5281847,
+RPA,FPLX,000421,RPA
+rPKA,FPLX,000390,PRKAR
+RPS6KA,FPLX,000329,P90RSK
+RSK,FPLX,000422,RSK
+RSK2,UP,P51812,KS6A3_HUMAN
+RTA,UP,O43251,RFOX2_HUMAN
+RTKs,FPLX,000423,RTK
+RUNX2,UP,Q13950,RUNX2_HUMAN
+rutin,CHEBI,CHEBI:28527,rutin
+rutin,PUBCHEM,5280805,
+RXR,FPLX,000424,RXR
+S100,FPLX,000425,S100
+S100A,FPLX,000426,S100A
+S100a,FPLX,000426,S100A
+S1P receptor,FPLX,000427,S1PR
+S1PR,FPLX,000427,S1PR
+S6,UP,P62753,RS6_HUMAN
+S6,IP,IPR000529,
+S6K,FPLX,000328,P70S6K
+S6K1,UP,P23443,KS6B1_HUMAN
+SAA,FPLX,000428,SAA
+SAC,GO,GO:0033316,meiotic spindle assembly checkpoint
+SAF-1,UP,P56270,MAZ_HUMAN
+SAHA,PUBCHEM,5311,
+SAHA,CHEBI,CHEBI:45716,vorinostat
+SAHA,CHEMBL,CHEMBL98,
+sarcoplasmic/endoplasmic reticulum calcium ATPase,FPLX,000430,SERCA
+SB203580,PUBCHEM,176155,
+SB203580,CHEBI,CHEBI:90705,SB 203580
+SCF,UP,P21583,SCF_HUMAN
+senescence,GO,GO:0090398,cellular senescence
+senescence,MESH,D016922,Cellular Senescence
+SERCA,FPLX,000430,SERCA
+SERCAs,FPLX,000430,SERCA
+SFK,FPLX,000451,SRC
+SFN,CHEBI,CHEBI:47807,sulforaphane
+SFN,PUBCHEM,5350,
+Shc family,FPLX,000432,SHC
+SHC,FPLX,000432,SHC
+Shc,FPLX,000432,SHC
+shikonin,CHEBI,CHEBI:81068,Shikonin
+shikonin,PUBCHEM,479503,
+SHP-2,UP,Q06124,PTN11_HUMAN
+SHP2,UP,Q06124,PTN11_HUMAN
+Shp2,UP,Q06124,PTN11_HUMAN
+Sialytransferase,FPLX,000202,GTF_family_29
+Sialytransferases,FPLX,000202,GTF_family_29
+sialytransferase,FPLX,000202,GTF_family_29
+sialytransferases,FPLX,000202,GTF_family_29
+signal transduction,GO,GO:0007165,signal transduction
+signal transduction,MESH,D015398,Signal Transduction
+simvastatin,CHEBI,CHEBI:9150,simvastatin
+simvastatin,PUBCHEM,54454,
+SIRT1,UP,Q96EB6,SIR1_HUMAN
+Sirt1,UP,Q96EB6,SIR1_HUMAN
+Skp2,UP,Q13309,SKP2_HUMAN
+SLC2,FPLX,000434,SLC2A
+slow myosin,FPLX,000299,MYL_slow
+SLP-76,UP,Q13094,LCP2_HUMAN
+SLRP,FPLX,000435,SLRP
+SLRPs,FPLX,000435,SLRP
+SLRR,FPLX,000435,SLRP
+SLRRs,FPLX,000435,SLRP
+SMAD 2/3,FPLX,000443,SMAD2_3
+SMAD,FPLX,000441,SMAD
+Smad,FPLX,000441,SMAD
+smad,FPLX,000441,SMAD
+Smad2,UP,Q15796,SMAD2_HUMAN
+smad2,UP,Q15796,SMAD2_HUMAN
+SMAD2/3,FPLX,000443,SMAD2_3
+Smad2/3,FPLX,000443,SMAD2_3
+Smad3,UP,P84022,SMAD3_HUMAN
+Smad4,UP,Q13485,SMAD4_HUMAN
+small HSPs,FPLX,000245,HSPB
+small leucine rich proteoglycan family,FPLX,000435,SLRP
+small leucine rich proteoglycan,FPLX,000435,SLRP
+small leucine rich proteoglycans,FPLX,000435,SLRP
+small leucine-rich proteoglycan family,FPLX,000435,SLRP
+small leucine-rich proteoglycan,FPLX,000435,SLRP
+small leucine-rich proteoglycans,FPLX,000435,SLRP
+SMC1,FPLX,000444,SMC1
+Smc1,FPLX,000444,SMC1
+SNAI family,FPLX,000446,SNAI
+SNAI,FPLX,000446,SNAI
+Snail,UP,O95863,SNAI1_HUMAN
+SOD,FPLX,000447,SOD
+Sorafenib,PUBCHEM,216239,
+Sorafenib,CHEBI,CHEBI:50924,sorafenib
+sorafenib,PUBCHEM,216239,
+sorafenib,CHEBI,CHEBI:50924,sorafenib
+SOS,FPLX,000448,SOS
+Sos-1,UP,Q07889,SOS1_HUMAN
+SOS1,UP,Q07889,SOS1_HUMAN
+Sos1,UP,Q07889,SOS1_HUMAN
+SOX2,UP,P48431,SOX2_HUMAN
+Sp1,UP,P08047,SP1_HUMAN
+SP600125,PUBCHEM,8515,
+SP600125,CHEBI,CHEBI:90695,"anthra[1,9-cd]pyrazol-6(2H)-one"
+SPC,CHEBI,CHEBI:17689,sphingosine-1-phosphocholine
+SPC,PUBCHEM,9847290,
+Sphingosine 1-phosphate receptor,FPLX,000427,S1PR
+sphingosine-1-phosphate receptors,FPLX,000427,S1PR
+SPRED,FPLX,000449,SPRED
+SPRY,FPLX,000450,SPRY
+SR Ca(2+)-ATPase,FPLX,000430,SERCA
+Src family kinase,FPLX,000451,SRC
+Src family,FPLX,000451,SRC
+src kinases,FPLX,000451,SRC
+SRC,UP,P12931,SRC_HUMAN
+Src,UP,P12931,SRC_HUMAN
+SRC-family kinases,FPLX,000451,SRC
+Src-kinases,FPLX,000451,SRC
+SREBF family,FPLX,000452,SREBF
+SREBF,FPLX,000452,SREBF
+SRF,UP,P11831,SRF_HUMAN
+StAR,HGNC,11359,STAR
+StAR,UP,P49675,STAR_HUMAN
+STAT,FPLX,000453,STAT
+STAT1,UP,P42224,STAT1_HUMAN
+STAT3,UP,P40763,STAT3_HUMAN
+Stat3,UP,P40763,STAT3_HUMAN
+STAT5,FPLX,000454,STAT5
+Stat5,FPLX,000454,STAT5
+STATs,FPLX,000453,STAT
+Staurosporine,PUBCHEM,44259,
+Staurosporine,CHEBI,CHEBI:15738,staurosporine
+staurosporine,PUBCHEM,44259,
+staurosporine,CHEBI,CHEBI:15738,staurosporine
+stearoyl-CoA 9-desaturase,FPLX,000429,SCD
+Stearoyl-CoA desaturase,FPLX,000429,SCD
+stearoyl-CoA desaturase,FPLX,000429,SCD
+sterol regulatory element binding protein,FPLX,000452,SREBF
+sterol regulatory element-binding factor,FPLX,000452,SREBF
+STING,UP,Q86WV6,STING_HUMAN
+STT3,FPLX,000455,STT3
+STZ,PUBCHEM,29327,
+STZ,UP,Q11206,SIA4C_HUMAN
+succinate dehydrogenase (ubiquinone),FPLX,000502,ETC_complex_II
+succinate dehydrogenase,FPLX,000502,ETC_complex_II
+Sulfonylurea Receptor,FPLX,000456,Sulfonylurea_receptor
+sulfonylurea receptor,FPLX,000456,Sulfonylurea_receptor
+sulfonylurea receptors,FPLX,000456,Sulfonylurea_receptor
+sulforaphane,PUBCHEM,5350,
+sulforaphane,CHEBI,CHEBI:47807,sulforaphane
+superoxide,CHEBI,CHEBI:18421,superoxide
+superoxide,PUBCHEM,5359597,
+SUR,FPLX,000456,Sulfonylurea_receptor
+Survivin,UP,O15392,BIRC5_HUMAN
+survivin,UP,O15392,BIRC5_HUMAN
+SWI and SNF complex,FPLX,000457,SWI_SNF
+SWI/SNF complex,FPLX,000457,SWI_SNF
+SWI/SNF,FPLX,000457,SWI_SNF
+SWI/SNF-like,FPLX,000457,SWI_SNF
+Syk,UP,P43405,KSYK_HUMAN
+SYNJ2,UP,O15056,SYNJ2_HUMAN
+T-cell factor (TCF)/lymphoid enhancer factor,FPLX,000460,TCF_LEF
+TAK1,UP,O43318,M3K7_HUMAN
+TAK165,PUBCHEM,6444692,
+tamoxifen,PUBCHEM,2733526,
+tamoxifen,CHEBI,CHEBI:41774,tamoxifen
+TAP transporter,FPLX,000459,TAP
+TAP,FPLX,000459,TAP
+TAp73,UP,O15350,P73_HUMAN
+TAS-116,PUBCHEM,67501411,
+Tat,UP,P04608,TAT_HV1H2
+tau,UP,P10636,TAU_HUMAN
+Tax,UP,P03409,TAX_HTL1A
+TBK1,UP,Q9UHD2,TBK1_HUMAN
+TCF,FPLX,000460,TCF_LEF
+Tcf,FPLX,000460,TCF_LEF
+Tcf/Lef,FPLX,000460,TCF_LEF
+TCR,FPLX,000461,TCR
+TDRG1,UP,Q3Y452,TDRG1_HUMAN
+telomerase,UP,O14746,TERT_HUMAN
+Temozolomide,CHEBI,CHEBI:72564,temozolomide
+Temozolomide,PUBCHEM,5394,
+temozolomide,CHEBI,CHEBI:72564,temozolomide
+temozolomide,PUBCHEM,5394,
+Tenascin,FPLX,000473,TN
+tenascin,FPLX,000473,TN
+TFDP,FPLX,000464,TFDP
+TFIIE,FPLX,000196,GTF2E
+TFIIF,FPLX,000197,GTF2F
+TGF beta receptor,FPLX,000466,TGFBR
+TGF beta,FPLX,000465,TGFB
+TGF β receptor,FPLX,000466,TGFBR
+TGF β,FPLX,000465,TGFB
+TGF-alpha,UP,P01135,TGFA_HUMAN
+TGF-b,FPLX,000465,TGFB
+TGF-beta family,FPLX,000465,TGFB
+TGF-beta receptor,FPLX,000466,TGFBR
+TGF-beta receptors,FPLX,000466,TGFBR
+TGF-beta,FPLX,000465,TGFB
+TGF-beta1,UP,P01137,TGFB1_HUMAN
+TGF-β receptor,FPLX,000466,TGFBR
+TGF-β receptors,FPLX,000466,TGFBR
+TGF-β,FPLX,000465,TGFB
+TGF-α,UP,P01135,TGFA_HUMAN
+TGF-β1,UP,P01137,TGFB1_HUMAN
+TGFalpha,UP,P01135,TGFA_HUMAN
+TGFB family,FPLX,000465,TGFB
+TGFB,FPLX,000465,TGFB
+TGFbeta,FPLX,000465,TGFB
+TGFbeta1,UP,P01137,TGFB1_HUMAN
+TGFBR family,FPLX,000466,TGFBR
+TGFBR,FPLX,000466,TGFBR
+TGFβ receptor,FPLX,000466,TGFBR
+TGFβ receptors,FPLX,000466,TGFBR
+TGFβ,FPLX,000465,TGFB
+TGFα,UP,P01135,TGFA_HUMAN
+TGFβ1,UP,P01137,TGFB1_HUMAN
+thapsigargin,PUBCHEM,446378,
+thapsigargin,CHEBI,CHEBI:9516,thapsigargin
+Thioredoxin reductase,FPLX,000488,TXNRD
+thioredoxin reductase,FPLX,000488,TXNRD
+Thioredoxin,FPLX,000487,TXN
+thioredoxin,FPLX,000487,TXN
+Thioredoxin,UP,P10599,THIO_HUMAN
+thioredoxin,UP,P10599,THIO_HUMAN
+thioredoxins,FPLX,000487,TXN
+thrombin,IP,IPR003966,
+thrombin,UP,P00734,THRB_HUMAN
+thrombin-anti-thrombin III complexes,FPLX,000469,Thrombin_antithrombin
+thrombospondin protein,FPLX,000467,THBS
+Thrombospondin,FPLX,000467,THBS
+thrombospondin,FPLX,000467,THBS
+Thrombospondins,FPLX,000467,THBS
+thrombospondins,FPLX,000467,THBS
+thyroid hormone receptor,FPLX,000468,THR
+TIAM,FPLX,000470,TIAM
+TIAM1,UP,Q13009,TIAM1_HUMAN
+Tiam1,UP,Q13009,TIAM1_HUMAN
+TIAM2,UP,Q8IVF5,TIAM2_HUMAN
+Tiam2,UP,Q8IVF5,TIAM2_HUMAN
+TIF-IB,FPLX,000471,TIF_IB
+tipifarnib,PUBCHEM,159324,
+tipifarnib,CHEBI,CHEBI:141969,tipifarnib
+tissue kallikrein,FPLX,000271,KLK
+tissue kallikreins,FPLX,000271,KLK
+TLR,FPLX,000472,TLR
+TLR2,UP,O60603,TLR2_HUMAN
+TLR4,UP,O00206,TLR4_HUMAN
+TMZ,CHEBI,CHEBI:72564,temozolomide
+TMZ,PUBCHEM,5394,
+TN-C,FPLX,000478,Troponin_C
+TnC,FPLX,000478,Troponin_C
+TNF,UP,P01375,TNFA_HUMAN
+TNF-alpha,UP,P01375,TNFA_HUMAN
+TNF-R superfamily,FPLX,000475,TNFRSF
+TNF-receptor family,FPLX,000475,TNFRSF
+TNF-α,UP,P01375,TNFA_HUMAN
+TNFalpha,UP,P01375,TNFA_HUMAN
+TNFR family,FPLX,000475,TNFRSF
+TNFR subfamily,FPLX,000475,TNFRSF
+TNFR superfamily members,FPLX,000475,TNFRSF
+TNFR superfamily receptors,FPLX,000475,TNFRSF
+TNFR superfamily,FPLX,000475,TNFRSF
+TNFR,FPLX,000475,TNFRSF
+TNFR1,UP,P19438,TNR1A_HUMAN
+TNFα,UP,P01375,TNFA_HUMAN
+topoisomerase II,FPLX,000476,TOP2
+TORC1,FPLX,000293,mTORC1
+TORC2,FPLX,000294,mTORC2
+TP53,UP,P04637,P53_HUMAN
+TPA,PUBCHEM,27924,
+TPA,CHEBI,CHEBI:37537,phorbol 13-acetate 12-myristate
+Tpl2,HGNC,6860,MAP3K8
+TPNI,FPLX,000479,Troponin_I
+TPNT,FPLX,000480,Troponin_T
+TQ,PUBCHEM,10281,
+TQ,CHEBI,CHEBI:113532,"2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione"
+TRAF2,UP,Q12933,TRAF2_HUMAN
+TRAF3,UP,Q13114,TRAF3_HUMAN
+TRAF6,UP,Q9Y4K3,TRAF6_HUMAN
+TRAIL,UP,P50591,TNF10_HUMAN
+trametinib,CHEBI,CHEBI:75998,trametinib
+trametinib,PUBCHEM,11707110,
+Transcription factor AP-2,FPLX,000463,TFAP2
+transcription factor AP-2,FPLX,000463,TFAP2
+transcription factor DP,FPLX,000464,TFDP
+transcription factor II E,FPLX,000196,GTF2E
+transcription factor II F,FPLX,000197,GTF2F
+transcription factor IIE,FPLX,000196,GTF2E
+transcription factor IIF,FPLX,000197,GTF2F
+transcription,GO,GO:0006351,"transcription, DNA-templated"
+transcription,MESH,D014158,"Transcription, Genetic"
+transcriptional cofactor complex CRSP,FPLX,000122,CRSP
+transforming growth factor beta,FPLX,000465,TGFB
+transforming growth factor β,FPLX,000465,TGFB
+transforming growth factor-beta,FPLX,000465,TGFB
+transforming growth factor-β,FPLX,000465,TGFB
+translation,GO,GO:0006412,translation
+translation,MESH,D014176,Protein Biosynthesis
+transport,GO,GO:0006810,transport
+trastuzumab,MESH,D000068878,Trastuzumab
+trastuzumab,CHEMBL,1201585,
+TRiC,FPLX,000085,CCT_complex
+TRIM,UP,Q6PIZ9,TRAT1_HUMAN
+Trk receptor,FPLX,000321,NTRK
+trk receptor,FPLX,000321,NTRK
+Trk receptors,FPLX,000321,NTRK
+trk receptors,FPLX,000321,NTRK
+TrkA,UP,P04629,NTRK1_HUMAN
+TrkB,UP,Q16620,NTRK2_HUMAN
+troponin C,FPLX,000478,Troponin_C
+troponin complex,FPLX,000477,Troponin
+troponin I,FPLX,000479,Troponin_I
+troponin T,FPLX,000480,Troponin_T
+troponin,FPLX,000477,Troponin
+troponins,FPLX,000477,Troponin
+trypsin,CHEBI,CHEBI:9765,Trypsin
+Tryptase,FPLX,000481,Tryptase
+tryptase,FPLX,000481,Tryptase
+tryptases,FPLX,000481,Tryptase
+TSA,PUBCHEM,444732,
+TSA,CHEBI,CHEBI:46024,trichostatin A
+TSC,FPLX,000482,TSC
+TSC1,UP,Q92574,TSC1_HUMAN
+TSC2,UP,P49815,TSC2_HUMAN
+TUBA,FPLX,000483,TUBA
+TUBB,FPLX,000484,TUBB
+tuberin,UP,P49815,TSC2_HUMAN
+tubulin alpha chain,FPLX,000483,TUBA
+tubulin beta chain,FPLX,000484,TUBB
+tubulin beta,FPLX,000484,TUBB
+tubulin delta,HGNC,16811,TUBD1
+tubulin epsilon,HGNC,20775,TUBE1
+tubulin gamma,FPLX,000485,TUBG
+tubulin α chain,FPLX,000483,TUBA
+tubulin β chain,FPLX,000484,TUBB
+tubulin β,FPLX,000484,TUBB
+tubulin γ,FPLX,000485,TUBG
+tubulin δ,HGNC,16811,TUBD1
+tubulin ε,HGNC,20775,TUBE1
+tubulin,FPLX,000486,Tubulin
+tumor necrosis factor,UP,P01375,TNFA_HUMAN
+tumorigenesis,MESH,D063646,Carcinogenesis
+tunicamycin,CHEBI,CHEBI:29699,tunicamycin
+tunicamycin,PUBCHEM,56927680,
+type 2 phosphatidic acid phosphatase,FPLX,000374,PPAP2
+type 2 phosphatidic acid phosphatases,FPLX,000374,PPAP2
+type 4 cyclic nucleotide phosphodiesterase,FPLX,000338,PDE4
+Type I collagen,FPLX,000109,COL1
+type I collagen,FPLX,000109,COL1
+type II phosphatidic acid phosphatase,FPLX,000374,PPAP2
+type II phosphatidic acid phosphatases,FPLX,000374,PPAP2
+type V collagen,FPLX,000111,COL5
+type-V collagen,FPLX,000111,COL5
+U0126,PUBCHEM,3006531,
+U0126,CHEBI,CHEBI:90693,U0126
+Ub,FPLX,000490,Ubiquitin
+ub,FPLX,000490,Ubiquitin
+UBE2,FPLX,000489,UBE2
+ubiquitin conjugating enzyme,FPLX,000489,UBE2
+Ubiquitin,FPLX,000490,Ubiquitin
+ubiquitin,FPLX,000490,Ubiquitin
+ubiquitin-conjugating enzymes,FPLX,000489,UBE2
+UGT,FPLX,000492,UGT
+uPA,UP,P00749,UROK_HUMAN
+uPAR,UP,Q03405,UPAR_HUMAN
+vascular endothelial growth factor,FPLX,000495,VEGF
+VAV family,FPLX,000494,VAV
+Vav,FPLX,000494,VAV
+Vav1,UP,P15498,VAV_HUMAN
+VCAM-1,UP,P19320,VCAM1_HUMAN
+VEGF receptor,FPLX,000496,VEGFR
+VEGF receptors,FPLX,000496,VEGFR
+VEGF,FPLX,000495,VEGF
+VEGF-A,UP,P15692,VEGFA_HUMAN
+VEGFR ligand,FPLX,000496,VEGFR
+VEGFR,FPLX,000496,VEGFR
+VEGFR-2,UP,P35968,VGFR2_HUMAN
+VEGFR2,UP,P35968,VGFR2_HUMAN
+VEGFRs,FPLX,000496,VEGFR
+Vemurafenib,PUBCHEM,42611257,
+Vemurafenib,CHEBI,CHEBI:63637,vemurafenib
+vemurafenib,PUBCHEM,42611257,
+vemurafenib,CHEBI,CHEBI:63637,vemurafenib
+vitronectin receptor (integrin),FPLX,000261,Integrins
+VLDL,CHEBI,CHEBI:39027,very-low-density lipoprotein
+vorinostat,PUBCHEM,5311,
+vorinostat,CHEBI,CHEBI:45716,vorinostat
+VPA,PUBCHEM,3121,
+VPA,CHEBI,CHEBI:39867,valproic acid
+Vpr,UP,P05928,VPR_HV1BR
+Vpu,UP,P05919,VPU_HV1H2
+WA,PUBCHEM,265237,
+WA,CHEBI,CHEBI:69120,withaferin A
+wild type c-Cbl,UP,P22681,CBL_HUMAN
+WNT,FPLX,000497,Wnt
+Wnt,FPLX,000497,Wnt
+Wnt5a,UP,P41221,WNT5A_HUMAN
+wogonin,PUBCHEM,5281703,
+wogonin,CHEBI,CHEBI:10043,wogonin
+XIAP,UP,P98170,XIAP_HUMAN
+XYLT,FPLX,000185,GCNT
+Xylosyltransferase,FPLX,000185,GCNT
+Xylosyltransferases,FPLX,000185,GCNT
+xylosyltransferase,FPLX,000185,GCNT
+xylosyltransferases,FPLX,000185,GCNT
+Y box binding protein,FPLX,000498,YBX
+Y-box-binding protein,FPLX,000498,YBX
+YAP,UP,P46937,YAP1_HUMAN
+YAP1,UP,P46937,YAP1_HUMAN
+YBX protein family,FPLX,000498,YBX
+ZEB1,UP,P37275,ZEB1_HUMAN
+Zeb1,UP,P37275,ZEB1_HUMAN
+β adrenergic receptor kinase,FPLX,000022,ADRBK
+α catenin,FPLX,000126,CTNNA
+β interferons,FPLX,000247,IFNB
+γ secretase,FPLX,000181,Gamma_secretase
+α tubulin,FPLX,000483,TUBA
+γ tubulin,FPLX,000485,TUBG
+α(2)-adrenoceptors,FPLX,000020,ADRA2
+α(2)-ARs,FPLX,000020,ADRA2
+α-adrenergic receptor,FPLX,000019,ADRA
+β-adrenergic receptor,FPLX,000021,ADRB
+α-adrenoreceptor,FPLX,000019,ADRA
+β-adrenoreceptor,FPLX,000021,ADRB
+α-adrenoreceptors,FPLX,000019,ADRA
+γ-aminobutyric-acid A receptor,FPLX,000179,GABR
+α-catenin,FPLX,000126,CTNNA
+β-catenin,UP,P35222,CTNB1_HUMAN
+β-TrCP,UP,Q9Y297,FBW1A_HUMAN
+γ-tubulin,FPLX,000485,TUBG
+δ-tubulin,HGNC,16811,TUBD1
+ε-tubulin,HGNC,20775,TUBE1
+α1β1γ1,FPLX,000032,AMPK_A1B1G1
+α1β1γ2,FPLX,000033,AMPK_A1B1G2
+α1β1γ3,FPLX,000034,AMPK_A1B1G3
+α1β2γ1,FPLX,000035,AMPK_A1B2G1
+α1β2γ2,FPLX,000036,AMPK_A1B2G2
+α2-AR,FPLX,000020,ADRA2
+α2β1γ1,FPLX,000038,AMPK_A2B1G1
+α2β2γ1,FPLX,000041,AMPK_A2B2G1
+α2β2γ2,FPLX,000042,AMPK_A2B2G2
+α2β2γ3,FPLX,000043,AMPK_A2B2G3
+βAR,FPLX,000021,ADRB
+βARK,FPLX,000022,ADRBK
+receptor,GO,GO:0038023,signaling receptor activity
+eGFR,MESH,D005919,Glomerular Filtration Rate
+CDK1/2,FPLX,000093,CDK1_2
+cdk1/2,FPLX,000093,CDK1_2
+Cdk1/2,FPLX,000093,CDK1_2
+Chk1/2,FPLX,000098,CHEK
+chromosomal instability,MESH,D043171,Chromosomal Instability
+chromosomal instability,NCIT,C48195,
+chromosomal instabiliy,MESH,D043171,Chromosomal Instability
+chromosomal instabiliy,NCIT,C48195,
+CIN,MESH,D043171,Chromosomal Instability
+CIN,NCIT,C48195,
+CycK,HGNC,1596,CCNK
+CycK1,HGNC,1596,CCNK
+dinaciclib,PUBCHEM,46926350,
+dinaciclib,CHEMBL,CHEMBL2103840,
+dinaciclib,CHEBI,CHEBI:95060,"2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol"
+Dinaciclib,PUBCHEM,46926350,
+Dinaciclib,CHEMBL,CHEMBL2103840,
+Dinaciclib,CHEBI,CHEBI:95060,"2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol"
+Ebp1,HGNC,8550,PA2G4
+EBP1,HGNC,8550,PA2G4
+erbB,FPLX,000160,ERBB
+Fer-1,PUBCHEM,4068248,
+HK2,HGNC,4923,HK2
+NLE,CHEBI,CHEBI:38473,azadirachtin
+PD-1,UP,Q15116,PDCD1_HUMAN
+PD-1,HGNC,8760,PDCD1
+Se,PUBCHEM,6326970,
+Se,CHEBI,CHEBI:27568,selenium atom
+THZ531,PUBCHEM,118025540,
+THZ531,CHEBI,CHEBI:143122,THZ531
+Hh,FPLX,000226,Hedgehog
+SIK,FPLX,000433,SIK
+salt inducible kinase,FPLX,000433,SIK
+Sik,UP,Q64434,PTK6_MOUSE
+DYRK,FPLX,000146,DYRK
+Augmin,FPLX,000061,Augmin
+HAUS,FPLX,000061,Augmin
+HAUS complex,FPLX,000061,Augmin
+CRTC,FPLX,000123,CRTC
diff --git a/famplex/resources/metadata.json b/famplex/resources/metadata.json
new file mode 100644
index 000000000..8e1c57a8e
--- /dev/null
+++ b/famplex/resources/metadata.json
@@ -0,0 +1,730 @@
+{
+  "Time Exported": "Sun Jul 21 18:47:42 2019",
+  "Unlabelled Groundings": [
+    {
+      "db": "CHEMBL",
+      "db_id": "1201577"
+    },
+    {
+      "db": "CHEMBL",
+      "db_id": "1201585"
+    },
+    {
+      "db": "CHEMBL",
+      "db_id": "CHEMBL2103840"
+    },
+    {
+      "db": "CHEMBL",
+      "db_id": "CHEMBL402548"
+    },
+    {
+      "db": "CHEMBL",
+      "db_id": "CHEMBL98"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00045"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00058"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00108"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00122"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00125"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00220"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00221"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00464"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB00538"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB01201"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB01273"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB01377"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB03378"
+    },
+    {
+      "db": "HMDB",
+      "db_id": "HMDB06219"
+    },
+    {
+      "db": "IP",
+      "db_id": "IPR000529"
+    },
+    {
+      "db": "IP",
+      "db_id": "IPR003966"
+    },
+    {
+      "db": "IP",
+      "db_id": "IPR015503"
+    },
+    {
+      "db": "LINCS",
+      "db_id": "10023-103"
+    },
+    {
+      "db": "LINCS",
+      "db_id": "10133-101"
+    },
+    {
+      "db": "LINCS",
+      "db_id": "10232-101"
+    },
+    {
+      "db": "LNCRNADB",
+      "db_id": "HOTAIR"
+    },
+    {
+      "db": "MESH",
+      "db_id": "0007249"
+    },
+    {
+      "db": "NCIT",
+      "db_id": "C16404"
+    },
+    {
+      "db": "NCIT",
+      "db_id": "C26169"
+    },
+    {
+      "db": "NCIT",
+      "db_id": "C48195"
+    },
+    {
+      "db": "NONCODE",
+      "db_id": "NONHSAT028507.2"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "10127622"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "10184653"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "10281"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "10494"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "10836"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "11302"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "11442891"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "11707110"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "118025540"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "11977753"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "123631"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "124886"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "135398619"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "135398633"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "135398634"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "135565635"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "145068"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "148124"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "1548943"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "159324"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "161468"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "16755649"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "176155"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "176870"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "208908"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "216239"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2214"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2244"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2346"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2353"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "23925"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "23973"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "24775005"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2519"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "25227462"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "265237"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2662"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "27099"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "271"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2733526"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "27854"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "27924"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "280"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "281"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2871439"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "2912"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "29327"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "3006531"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "3062316"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "3121"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "31703"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "3218"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "3220"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "36462"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "370"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "375150"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "3763"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "387447"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "4068248"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "4091"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "42611257"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "441203"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "442534"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "44259"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "443227"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "44462760"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "444732"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "444795"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "445154"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "446220"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "446378"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "446512"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "462382"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "46907787"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "46926350"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "479503"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "4878"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "518605"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5280343"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5280443"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5280445"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5280805"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5280896"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5280961"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281222"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281611"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281612"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281614"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281647"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281703"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281787"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5281847"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5284373"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5284616"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5291"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5311"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5350"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5352425"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5359596"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5359597"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5394"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "544"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "54454"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "54671203"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5469318"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5538"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "56927680"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5743"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5746"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5839"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5884"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5957"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5994"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "5997"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6022"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6026790"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6076"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6083"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6112"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6325610"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6326970"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6442177"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6444692"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "65064"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "65110"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6623"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "67501411"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "681"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6857599"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "68827"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "6918483"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "702"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "73659"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "77999"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "784"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "8144759"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "8249"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "8515"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "896"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "91435"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "969516"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "977"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "9811784"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "9847290"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "985"
+    },
+    {
+      "db": "PUBCHEM",
+      "db_id": "9887712"
+    },
+    {
+      "db": "UP",
+      "db_id": "I1YP21"
+    },
+    {
+      "db": "UP",
+      "db_id": "P0CW71"
+    },
+    {
+      "db": "UP",
+      "db_id": "Q157B2"
+    },
+    {
+      "db": "UP",
+      "db_id": "U3LIR9"
+    }
+  ],
+  "Unlabelled Relations": []
+}
\ No newline at end of file
diff --git a/famplex/resources/relations.csv b/famplex/resources/relations.csv
new file mode 100644
index 000000000..8162d5939
--- /dev/null
+++ b/famplex/resources/relations.csv
@@ -0,0 +1,2784 @@
+HGNC,3288,EIF4EBP1,isa,FPLX,000154,EIF4EBP
+HGNC,3289,EIF4EBP2,isa,FPLX,000154,EIF4EBP
+HGNC,3290,EIF4EBP3,isa,FPLX,000154,EIF4EBP
+HGNC,129,ACTA1,isa,FPLX,000009,Actin
+HGNC,130,ACTA2,isa,FPLX,000009,Actin
+HGNC,132,ACTB,isa,FPLX,000009,Actin
+HGNC,143,ACTC1,isa,FPLX,000009,Actin
+HGNC,144,ACTG1,isa,FPLX,000009,Actin
+HGNC,145,ACTG2,isa,FPLX,000009,Actin
+FPLX,000011,Activin_A,isa,FPLX,000010,Activin
+FPLX,000012,Activin_AB,isa,FPLX,000010,Activin
+FPLX,000013,Activin_B,isa,FPLX,000010,Activin
+FPLX,000257,Inhibin_A,isa,FPLX,000256,Inhibin
+FPLX,000258,Inhibin_B,isa,FPLX,000256,Inhibin
+HGNC,6066,INHBA,partof,FPLX,000011,Activin_A
+HGNC,6066,INHBA,partof,FPLX,000012,Activin_AB
+HGNC,6067,INHBB,partof,FPLX,000012,Activin_AB
+HGNC,6067,INHBB,partof,FPLX,000013,Activin_B
+HGNC,6065,INHA,partof,FPLX,000257,Inhibin_A
+HGNC,6066,INHBA,partof,FPLX,000257,Inhibin_A
+HGNC,6065,INHA,partof,FPLX,000258,Inhibin_B
+HGNC,6067,INHBB,partof,FPLX,000258,Inhibin_B
+HGNC,391,AKT1,isa,FPLX,000023,AKT
+HGNC,392,AKT2,isa,FPLX,000023,AKT
+HGNC,393,AKT3,isa,FPLX,000023,AKT
+FPLX,000044,AMPK_alpha,partof,FPLX,000031,AMPK
+FPLX,000045,AMPK_beta,partof,FPLX,000031,AMPK
+FPLX,000046,AMPK_gamma,partof,FPLX,000031,AMPK
+HGNC,9376,PRKAA1,isa,FPLX,000044,AMPK_alpha
+HGNC,9377,PRKAA2,isa,FPLX,000044,AMPK_alpha
+HGNC,9378,PRKAB1,isa,FPLX,000045,AMPK_beta
+HGNC,9379,PRKAB2,isa,FPLX,000045,AMPK_beta
+HGNC,9385,PRKAG1,isa,FPLX,000046,AMPK_gamma
+HGNC,9386,PRKAG2,isa,FPLX,000046,AMPK_gamma
+HGNC,9387,PRKAG3,isa,FPLX,000046,AMPK_gamma
+FPLX,000032,AMPK_A1B1G1,isa,FPLX,000031,AMPK
+HGNC,9376,PRKAA1,partof,FPLX,000032,AMPK_A1B1G1
+HGNC,9378,PRKAB1,partof,FPLX,000032,AMPK_A1B1G1
+HGNC,9385,PRKAG1,partof,FPLX,000032,AMPK_A1B1G1
+FPLX,000033,AMPK_A1B1G2,isa,FPLX,000031,AMPK
+HGNC,9376,PRKAA1,partof,FPLX,000033,AMPK_A1B1G2
+HGNC,9378,PRKAB1,partof,FPLX,000033,AMPK_A1B1G2
+HGNC,9386,PRKAG2,partof,FPLX,000033,AMPK_A1B1G2
+FPLX,000034,AMPK_A1B1G3,isa,FPLX,000031,AMPK
+HGNC,9376,PRKAA1,partof,FPLX,000034,AMPK_A1B1G3
+HGNC,9378,PRKAB1,partof,FPLX,000034,AMPK_A1B1G3
+HGNC,9387,PRKAG3,partof,FPLX,000034,AMPK_A1B1G3
+FPLX,000035,AMPK_A1B2G1,isa,FPLX,000031,AMPK
+HGNC,9376,PRKAA1,partof,FPLX,000035,AMPK_A1B2G1
+HGNC,9379,PRKAB2,partof,FPLX,000035,AMPK_A1B2G1
+HGNC,9385,PRKAG1,partof,FPLX,000035,AMPK_A1B2G1
+FPLX,000036,AMPK_A1B2G2,isa,FPLX,000031,AMPK
+HGNC,9376,PRKAA1,partof,FPLX,000036,AMPK_A1B2G2
+HGNC,9379,PRKAB2,partof,FPLX,000036,AMPK_A1B2G2
+HGNC,9386,PRKAG2,partof,FPLX,000036,AMPK_A1B2G2
+FPLX,000037,AMPK_A1B2G3,isa,FPLX,000031,AMPK
+HGNC,9376,PRKAA1,partof,FPLX,000037,AMPK_A1B2G3
+HGNC,9379,PRKAB2,partof,FPLX,000037,AMPK_A1B2G3
+HGNC,9387,PRKAG3,partof,FPLX,000037,AMPK_A1B2G3
+FPLX,000038,AMPK_A2B1G1,isa,FPLX,000031,AMPK
+HGNC,9377,PRKAA2,partof,FPLX,000038,AMPK_A2B1G1
+HGNC,9378,PRKAB1,partof,FPLX,000038,AMPK_A2B1G1
+HGNC,9385,PRKAG1,partof,FPLX,000038,AMPK_A2B1G1
+FPLX,000039,AMPK_A2B1G2,isa,FPLX,000031,AMPK
+HGNC,9377,PRKAA2,partof,FPLX,000039,AMPK_A2B1G2
+HGNC,9378,PRKAB1,partof,FPLX,000039,AMPK_A2B1G2
+HGNC,9386,PRKAG2,partof,FPLX,000039,AMPK_A2B1G2
+FPLX,000040,AMPK_A2B1G3,isa,FPLX,000031,AMPK
+HGNC,9377,PRKAA2,partof,FPLX,000040,AMPK_A2B1G3
+HGNC,9378,PRKAB1,partof,FPLX,000040,AMPK_A2B1G3
+HGNC,9387,PRKAG3,partof,FPLX,000040,AMPK_A2B1G3
+FPLX,000041,AMPK_A2B2G1,isa,FPLX,000031,AMPK
+HGNC,9377,PRKAA2,partof,FPLX,000041,AMPK_A2B2G1
+HGNC,9379,PRKAB2,partof,FPLX,000041,AMPK_A2B2G1
+HGNC,9385,PRKAG1,partof,FPLX,000041,AMPK_A2B2G1
+FPLX,000042,AMPK_A2B2G2,isa,FPLX,000031,AMPK
+HGNC,9377,PRKAA2,partof,FPLX,000042,AMPK_A2B2G2
+HGNC,9379,PRKAB2,partof,FPLX,000042,AMPK_A2B2G2
+HGNC,9386,PRKAG2,partof,FPLX,000042,AMPK_A2B2G2
+FPLX,000043,AMPK_A2B2G3,isa,FPLX,000031,AMPK
+HGNC,9377,PRKAA2,partof,FPLX,000043,AMPK_A2B2G3
+HGNC,9379,PRKAB2,partof,FPLX,000043,AMPK_A2B2G3
+HGNC,9387,PRKAG3,partof,FPLX,000043,AMPK_A2B2G3
+HGNC,561,AP2A1,isa,FPLX,000049,AP2A
+HGNC,562,AP2A2,isa,FPLX,000049,AP2A
+HGNC,563,AP2B1,partof,FPLX,000015,Adaptor_protein_II
+HGNC,564,AP2M1,partof,FPLX,000015,Adaptor_protein_II
+HGNC,565,AP2S1,partof,FPLX,000015,Adaptor_protein_II
+FPLX,000049,AP2A,partof,FPLX,000015,Adaptor_protein_II
+HGNC,3796,FOS,isa,FPLX,000173,FOS_family
+HGNC,3797,FOSB,isa,FPLX,000173,FOS_family
+HGNC,13718,FOSL1,isa,FPLX,000173,FOS_family
+HGNC,3798,FOSL2,isa,FPLX,000173,FOS_family
+FPLX,000173,FOS_family,partof,FPLX,000048,AP1
+HGNC,6204,JUN,isa,FPLX,000268,JUN_family
+HGNC,6205,JUNB,isa,FPLX,000268,JUN_family
+HGNC,6206,JUND,isa,FPLX,000268,JUN_family
+FPLX,000268,JUN_family,partof,FPLX,000048,AP1
+HGNC,1499,CASP1,isa,FPLX,000081,Caspase
+HGNC,1503,CASP2,isa,FPLX,000081,Caspase
+HGNC,1504,CASP3,isa,FPLX,000082,Caspase_3_7
+HGNC,1505,CASP4,isa,FPLX,000081,Caspase
+HGNC,1506,CASP5,isa,FPLX,000081,Caspase
+HGNC,1507,CASP6,isa,FPLX,000081,Caspase
+HGNC,1508,CASP7,isa,FPLX,000082,Caspase_3_7
+HGNC,1509,CASP8,isa,FPLX,000081,Caspase
+HGNC,1511,CASP9,isa,FPLX,000081,Caspase
+HGNC,1500,CASP10,isa,FPLX,000081,Caspase
+HGNC,19004,CASP12,isa,FPLX,000081,Caspase
+HGNC,1502,CASP14,isa,FPLX,000081,Caspase
+FPLX,000082,Caspase_3_7,isa,FPLX,000081,Caspase
+HGNC,1781,CDKL1,isa,FPLX,000092,CDK
+HGNC,1782,CDKL2,isa,FPLX,000092,CDK
+HGNC,15483,CDKL3,isa,FPLX,000092,CDK
+HGNC,19287,CDKL4,isa,FPLX,000092,CDK
+HGNC,11411,CDKL5,isa,FPLX,000092,CDK
+HGNC,1722,CDK1,isa,FPLX,000093,CDK1_2
+HGNC,1771,CDK2,isa,FPLX,000093,CDK1_2
+FPLX,000093,CDK1_2,isa,FPLX,000092,CDK
+HGNC,1772,CDK3,isa,FPLX,000092,CDK
+HGNC,1773,CDK4,isa,FPLX,000092,CDK
+HGNC,1774,CDK5,isa,FPLX,000092,CDK
+HGNC,1777,CDK6,isa,FPLX,000092,CDK
+HGNC,1778,CDK7,isa,FPLX,000092,CDK
+HGNC,1779,CDK8,isa,FPLX,000092,CDK
+HGNC,1780,CDK9,isa,FPLX,000092,CDK
+HGNC,1770,CDK10,isa,FPLX,000092,CDK
+HGNC,1730,CDK11A,isa,FPLX,000092,CDK
+HGNC,1729,CDK11B,isa,FPLX,000092,CDK
+HGNC,24224,CDK12,isa,FPLX,000092,CDK
+HGNC,1733,CDK13,isa,FPLX,000092,CDK
+HGNC,8883,CDK14,isa,FPLX,000092,CDK
+HGNC,14434,CDK15,isa,FPLX,000092,CDK
+HGNC,8749,CDK16,isa,FPLX,000092,CDK
+HGNC,8750,CDK17,isa,FPLX,000092,CDK
+HGNC,8751,CDK18,isa,FPLX,000092,CDK
+HGNC,19338,CDK19,isa,FPLX,000092,CDK
+HGNC,21420,CDK20,isa,FPLX,000092,CDK
+HGNC,2457,CSNK2A1,isa,FPLX,000125,CSNK2
+HGNC,2459,CSNK2A2,isa,FPLX,000125,CSNK2
+HGNC,2457,CSNK2A1,partof,FPLX,000104,CK2
+HGNC,2459,CSNK2A2,partof,FPLX,000104,CK2
+HGNC,2460,CSNK2B,partof,FPLX,000104,CK2
+HGNC,2451,CSNK1A1,isa,FPLX,000124,CSNK1
+HGNC,20289,CSNK1A1L,isa,FPLX,000124,CSNK1
+HGNC,2452,CSNK1D,isa,FPLX,000124,CSNK1
+HGNC,2453,CSNK1E,isa,FPLX,000124,CSNK1
+HGNC,2454,CSNK1G1,isa,FPLX,000124,CSNK1
+HGNC,2455,CSNK1G2,isa,FPLX,000124,CSNK1
+HGNC,2456,CSNK1G3,isa,FPLX,000124,CSNK1
+HGNC,1874,CFL1,isa,FPLX,000107,Cofilin
+HGNC,1875,CFL2,isa,FPLX,000107,Cofilin
+HGNC,15750,DSTN,isa,FPLX,000107,Cofilin
+HGNC,2345,CREB1,isa,FPLX,000120,CREB
+HGNC,2347,CREB3,isa,FPLX,000120,CREB
+HGNC,16844,CREB5,isa,FPLX,000120,CREB
+HGNC,18856,CREB3L1,isa,FPLX,000120,CREB
+HGNC,23720,CREB3L2,isa,FPLX,000120,CREB
+HGNC,18855,CREB3L3,isa,FPLX,000120,CREB
+HGNC,18854,CREB3L4,isa,FPLX,000120,CREB
+HGNC,2352,CREM,isa,FPLX,000120,CREB
+HGNC,783,ATF1,isa,FPLX,000120,CREB
+HGNC,784,ATF2,isa,FPLX,000120,CREB
+HGNC,1577,CCNA1,isa,FPLX,000131,Cyclin_A
+HGNC,1578,CCNA2,isa,FPLX,000131,Cyclin_A
+HGNC,1579,CCNB1,isa,FPLX,000130,Cyclin
+HGNC,1580,CCNB2,isa,FPLX,000130,Cyclin
+HGNC,18709,CCNB3,isa,FPLX,000130,Cyclin
+HGNC,1581,CCNC,isa,FPLX,000130,Cyclin
+HGNC,1582,CCND1,isa,FPLX,000132,Cyclin_D
+HGNC,1583,CCND2,isa,FPLX,000132,Cyclin_D
+HGNC,1585,CCND3,isa,FPLX,000132,Cyclin_D
+HGNC,1589,CCNE1,isa,FPLX,000133,Cyclin_E
+HGNC,1590,CCNE2,isa,FPLX,000133,Cyclin_E
+HGNC,1591,CCNF,isa,FPLX,000130,Cyclin
+HGNC,1592,CCNG1,isa,FPLX,000130,Cyclin
+HGNC,1593,CCNG2,isa,FPLX,000130,Cyclin
+HGNC,1594,CCNH,isa,FPLX,000130,Cyclin
+HGNC,1595,CCNI,isa,FPLX,000130,Cyclin
+HGNC,33869,CCNI2,isa,FPLX,000130,Cyclin
+HGNC,23434,CCNJ,isa,FPLX,000130,Cyclin
+HGNC,25876,CCNJL,isa,FPLX,000130,Cyclin
+HGNC,1596,CCNK,isa,FPLX,000130,Cyclin
+HGNC,20569,CCNL1,isa,FPLX,000130,Cyclin
+HGNC,20570,CCNL2,isa,FPLX,000130,Cyclin
+HGNC,18576,CCNO,isa,FPLX,000130,Cyclin
+HGNC,1599,CCNT1,isa,FPLX,000130,Cyclin
+HGNC,1600,CCNT2,isa,FPLX,000130,Cyclin
+HGNC,23354,CCNY,isa,FPLX,000130,Cyclin
+HGNC,26868,CCNYL1,isa,FPLX,000130,Cyclin
+HGNC,33206,CCNYL3,isa,FPLX,000130,Cyclin
+FPLX,000131,Cyclin_A,isa,FPLX,000130,Cyclin
+FPLX,000132,Cyclin_D,isa,FPLX,000130,Cyclin
+FPLX,000133,Cyclin_E,isa,FPLX,000130,Cyclin
+HGNC,6871,MAPK1,isa,FPLX,000161,ERK
+HGNC,6877,MAPK3,isa,FPLX,000161,ERK
+FPLX,000161,ERK,isa,FPLX,000283,MAPK
+FPLX,000178,F_actin,isa,FPLX,000009,Actin
+HGNC,3688,FGFR1,isa,FPLX,000168,FGFR
+HGNC,3689,FGFR2,isa,FPLX,000168,FGFR
+HGNC,3690,FGFR3,isa,FPLX,000168,FGFR
+HGNC,3691,FGFR4,isa,FPLX,000168,FGFR
+HGNC,3693,FGFRL1,isa,FPLX,000168,FGFR
+HGNC,4616,GSK3A,isa,FPLX,000194,GSK3
+HGNC,4617,GSK3B,isa,FPLX,000194,GSK3
+HGNC,4852,HDAC1,isa,FPLX,000221,HDAC_I
+HGNC,4853,HDAC2,isa,FPLX,000221,HDAC_I
+HGNC,4854,HDAC3,isa,FPLX,000221,HDAC_I
+HGNC,13315,HDAC8,isa,FPLX,000221,HDAC_I
+HGNC,14063,HDAC4,isa,FPLX,000222,HDAC_II
+HGNC,14068,HDAC5,isa,FPLX,000222,HDAC_II
+HGNC,14067,HDAC7,isa,FPLX,000222,HDAC_II
+HGNC,14065,HDAC9,isa,FPLX,000222,HDAC_II
+HGNC,14064,HDAC6,isa,FPLX,000222,HDAC_II
+HGNC,18128,HDAC10,isa,FPLX,000222,HDAC_II
+HGNC,14929,SIRT1,isa,FPLX,000223,HDAC_III
+HGNC,10886,SIRT2,isa,FPLX,000223,HDAC_III
+HGNC,14931,SIRT3,isa,FPLX,000223,HDAC_III
+HGNC,14932,SIRT4,isa,FPLX,000223,HDAC_III
+HGNC,14933,SIRT5,isa,FPLX,000223,HDAC_III
+HGNC,14934,SIRT6,isa,FPLX,000223,HDAC_III
+HGNC,14935,SIRT7,isa,FPLX,000223,HDAC_III
+HGNC,19086,HDAC11,isa,FPLX,000224,HDAC_IV
+FPLX,000221,HDAC_I,isa,FPLX,000220,HDAC
+FPLX,000222,HDAC_II,isa,FPLX,000220,HDAC
+FPLX,000223,HDAC_III,isa,FPLX,000220,HDAC
+FPLX,000224,HDAC_IV,isa,FPLX,000220,HDAC
+HGNC,4910,HIF1A,partof,FPLX,000230,HIF1
+HGNC,700,ARNT,partof,FPLX,000230,HIF1
+HGNC,4910,HIF1A,isa,FPLX,000231,HIF_alpha
+HGNC,3374,EPAS1,isa,FPLX,000231,HIF_alpha
+HGNC,15825,HIF3A,isa,FPLX,000231,HIF_alpha
+HGNC,700,ARNT,isa,FPLX,000232,HIF_beta
+HGNC,16876,ARNT2,isa,FPLX,000232,HIF_beta
+HGNC,701,ARNTL,isa,FPLX,000232,HIF_beta
+FPLX,000231,HIF_alpha,partof,FPLX,000229,HIF
+FPLX,000232,HIF_beta,partof,FPLX,000229,HIF
+FPLX,000242,HSP90A,isa,FPLX,000241,HSP90
+FPLX,000243,HSP90AA,isa,FPLX,000242,HSP90A
+HGNC,5253,HSP90AA1,isa,FPLX,000243,HSP90AA
+HGNC,5258,HSP90AB1,isa,FPLX,000242,HSP90A
+HGNC,12028,HSP90B1,isa,FPLX,000241,HSP90
+HGNC,16264,TRAP1,isa,FPLX,000241,HSP90
+FPLX,000234,Histone_H1,isa,FPLX,000233,Histone
+FPLX,000235,Histone_H2A,isa,FPLX,000233,Histone
+FPLX,000236,Histone_H2B,isa,FPLX,000233,Histone
+FPLX,000237,Histone_H3,isa,FPLX,000233,Histone
+FPLX,000238,Histone_H4,isa,FPLX,000233,Histone
+HGNC,4714,H1F0,isa,FPLX,000234,Histone_H1
+HGNC,18463,H1FOO,isa,FPLX,000234,Histone_H1
+HGNC,4722,H1FX,isa,FPLX,000234,Histone_H1
+HGNC,4715,HIST1H1A,isa,FPLX,000234,Histone_H1
+HGNC,4719,HIST1H1B,isa,FPLX,000234,Histone_H1
+HGNC,4716,HIST1H1C,isa,FPLX,000234,Histone_H1
+HGNC,4717,HIST1H1D,isa,FPLX,000234,Histone_H1
+HGNC,4718,HIST1H1E,isa,FPLX,000234,Histone_H1
+HGNC,4720,HIST1H1T,isa,FPLX,000234,Histone_H1
+HGNC,24893,H1FNT,isa,FPLX,000234,Histone_H1
+UP,P0C0S8,H2A1_HUMAN,isa,FPLX,000235,Histone_H2A
+HGNC,22516,H2AFB1,isa,FPLX,000235,Histone_H2A
+UP,P0C5Y9,H2AB1_HUMAN,isa,FPLX,000235,Histone_H2A
+HGNC,14456,H2AFJ,isa,FPLX,000235,Histone_H2A
+HGNC,20664,H2AFV,isa,FPLX,000235,Histone_H2A
+HGNC,4739,H2AFX,isa,FPLX,000235,Histone_H2A
+HGNC,4740,H2AFY,isa,FPLX,000235,Histone_H2A
+HGNC,14453,H2AFY2,isa,FPLX,000235,Histone_H2A
+HGNC,4741,H2AFZ,isa,FPLX,000235,Histone_H2A
+HGNC,18729,HIST1H2AA,isa,FPLX,000235,Histone_H2A
+HGNC,4733,HIST1H2AC,isa,FPLX,000235,Histone_H2A
+HGNC,4729,HIST1H2AD,isa,FPLX,000235,Histone_H2A
+HGNC,13671,HIST1H2AH,isa,FPLX,000235,Histone_H2A
+HGNC,4727,HIST1H2AJ,isa,FPLX,000235,Histone_H2A
+HGNC,20508,HIST2H2AB,isa,FPLX,000235,Histone_H2A
+HGNC,4738,HIST2H2AC,isa,FPLX,000235,Histone_H2A
+HGNC,20507,HIST3H2A,isa,FPLX,000235,Histone_H2A
+UP,P04908,H2A1B_HUMAN,isa,FPLX,000235,Histone_H2A
+UP,Q6FI13,H2A2A_HUMAN,isa,FPLX,000235,Histone_H2A
+UP,P62807,H2B1C_HUMAN,isa,FPLX,000236,Histone_H2B
+HGNC,18730,HIST1H2BA,isa,FPLX,000236,Histone_H2B
+HGNC,4751,HIST1H2BB,isa,FPLX,000236,Histone_H2B
+HGNC,4747,HIST1H2BD,isa,FPLX,000236,Histone_H2B
+HGNC,4755,HIST1H2BH,isa,FPLX,000236,Histone_H2B
+HGNC,4761,HIST1H2BJ,isa,FPLX,000236,Histone_H2B
+HGNC,13954,HIST1H2BK,isa,FPLX,000236,Histone_H2B
+HGNC,4748,HIST1H2BL,isa,FPLX,000236,Histone_H2B
+HGNC,4750,HIST1H2BM,isa,FPLX,000236,Histone_H2B
+HGNC,4749,HIST1H2BN,isa,FPLX,000236,Histone_H2B
+HGNC,4758,HIST1H2BO,isa,FPLX,000236,Histone_H2B
+HGNC,20516,HIST2H2BC,isa,FPLX,000236,Histone_H2B
+HGNC,20517,HIST2H2BD,isa,FPLX,000236,Histone_H2B
+HGNC,4760,HIST2H2BE,isa,FPLX,000236,Histone_H2B
+HGNC,24700,HIST2H2BF,isa,FPLX,000236,Histone_H2B
+HGNC,20514,HIST3H2BB,isa,FPLX,000236,Histone_H2B
+HGNC,4762,H2BFS,isa,FPLX,000236,Histone_H2B
+HGNC,27867,H2BFM,isa,FPLX,000236,Histone_H2B
+HGNC,27252,H2BFWT,isa,FPLX,000236,Histone_H2B
+UP,P68431,H31_HUMAN,isa,FPLX,000237,Histone_H3
+UP,Q71DI3,H32_HUMAN,isa,FPLX,000237,Histone_H3
+HGNC,4778,HIST3H3,isa,FPLX,000237,Histone_H3
+UP,P84243,H33_HUMAN,isa,FPLX,000237,Histone_H3
+HGNC,33164,H3F3C,isa,FPLX,000237,Histone_H3
+UP,P62805,H4_HUMAN,isa,FPLX,000238,Histone_H4
+HGNC,4792,HIST1H4G,isa,FPLX,000238,Histone_H4
+HGNC,11362,STAT1,isa,FPLX,000453,STAT
+HGNC,11363,STAT2,isa,FPLX,000453,STAT
+HGNC,11364,STAT3,isa,FPLX,000453,STAT
+HGNC,11365,STAT4,isa,FPLX,000453,STAT
+HGNC,11366,STAT5A,isa,FPLX,000454,STAT5
+HGNC,11367,STAT5B,isa,FPLX,000454,STAT5
+HGNC,11368,STAT6,isa,FPLX,000453,STAT
+FPLX,000454,STAT5,isa,FPLX,000453,STAT
+HGNC,8799,PDGFA,isa,FPLX,000342,PDGF
+HGNC,8800,PDGFB,isa,FPLX,000342,PDGF
+HGNC,8801,PDGFC,isa,FPLX,000342,PDGF
+HGNC,30620,PDGFD,isa,FPLX,000342,PDGF
+HGNC,8799,PDGFA,partof,FPLX,000347,PDGF_AA
+HGNC,8799,PDGFA,partof,FPLX,000348,PDGF_AB
+HGNC,8800,PDGFB,partof,FPLX,000348,PDGF_AB
+HGNC,8800,PDGFB,partof,FPLX,000349,PDGF_BB
+HGNC,8801,PDGFC,partof,FPLX,000350,PDGF_CC
+HGNC,30620,PDGFD,partof,FPLX,000351,PDGF_DD
+HGNC,8803,PDGFRA,isa,FPLX,000343,PDGFR
+HGNC,8804,PDGFRB,isa,FPLX,000343,PDGFR
+HGNC,8803,PDGFRA,partof,FPLX,000344,PDGFR_AA
+HGNC,8803,PDGFRA,partof,FPLX,000345,PDGFR_AB
+HGNC,8804,PDGFRB,partof,FPLX,000345,PDGFR_AB
+HGNC,8804,PDGFRB,partof,FPLX,000346,PDGFR_BB
+HGNC,4389,GNAO1,isa,FPLX,000213,G_i_alpha
+HGNC,4384,GNAI1,isa,FPLX,000213,G_i_alpha
+HGNC,4385,GNAI2,isa,FPLX,000213,G_i_alpha
+HGNC,4387,GNAI3,isa,FPLX,000213,G_i_alpha
+HGNC,4393,GNAT1,isa,FPLX,000213,G_i_alpha
+HGNC,4394,GNAT2,isa,FPLX,000213,G_i_alpha
+HGNC,22800,GNAT3,isa,FPLX,000213,G_i_alpha
+HGNC,4395,GNAZ,isa,FPLX,000213,G_i_alpha
+HGNC,4392,GNAS,isa,FPLX,000218,G_s_alpha
+HGNC,4388,GNAL,isa,FPLX,000218,G_s_alpha
+HGNC,4390,GNAQ,isa,FPLX,000216,G_q_alpha
+HGNC,4379,GNA11,isa,FPLX,000216,G_q_alpha
+HGNC,4382,GNA14,isa,FPLX,000216,G_q_alpha
+HGNC,4383,GNA15,isa,FPLX,000216,G_q_alpha
+HGNC,4380,GNA12,isa,FPLX,000208,G_12_alpha
+HGNC,4381,GNA13,isa,FPLX,000208,G_12_alpha
+FPLX,000213,G_i_alpha,isa,FPLX,000209,G_alpha
+FPLX,000218,G_s_alpha,isa,FPLX,000209,G_alpha
+FPLX,000216,G_q_alpha,isa,FPLX,000209,G_alpha
+FPLX,000208,G_12_alpha,isa,FPLX,000209,G_alpha
+FPLX,000213,G_i_alpha,partof,FPLX,000212,G_i
+FPLX,000218,G_s_alpha,partof,FPLX,000217,G_s
+FPLX,000216,G_q_alpha,partof,FPLX,000215,G_q
+FPLX,000208,G_12_alpha,partof,FPLX,000207,G_12
+FPLX,000212,G_i,isa,FPLX,000214,G_protein
+FPLX,000217,G_s,isa,FPLX,000214,G_protein
+FPLX,000215,G_q,isa,FPLX,000214,G_protein
+FPLX,000207,G_12,isa,FPLX,000214,G_protein
+HGNC,19989,ANAPC2,partof,FPLX,000050,APC_C
+HGNC,14452,ANAPC11,partof,FPLX,000050,APC_C
+HGNC,19988,ANAPC1,partof,FPLX,000050,APC_C
+HGNC,1720,CDC16,partof,FPLX,000050,APC_C
+HGNC,1728,CDC27,partof,FPLX,000050,APC_C
+HGNC,1724,CDC23,partof,FPLX,000050,APC_C
+HGNC,15713,ANAPC5,partof,FPLX,000050,APC_C
+HGNC,24077,ANAPC10,partof,FPLX,000050,APC_C
+HGNC,24531,ANAPC15,partof,FPLX,000050,APC_C
+HGNC,24540,ANAPC13,partof,FPLX,000050,APC_C
+HGNC,17839,CDC26,partof,FPLX,000050,APC_C
+HGNC,26976,ANAPC16,partof,FPLX,000050,APC_C
+HGNC,17380,ANAPC7,partof,FPLX,000050,APC_C
+HGNC,19990,ANAPC4,partof,FPLX,000050,APC_C
+HGNC,3236,EGFR,isa,FPLX,000160,ERBB
+HGNC,3430,ERBB2,isa,FPLX,000160,ERBB
+HGNC,3431,ERBB3,isa,FPLX,000160,ERBB
+HGNC,3432,ERBB4,isa,FPLX,000160,ERBB
+HGNC,3296,EIF4G1,isa,FPLX,000155,EIF4G
+HGNC,3297,EIF4G2,isa,FPLX,000155,EIF4G
+HGNC,3298,EIF4G3,isa,FPLX,000155,EIF4G
+HGNC,7775,NFATC1,isa,FPLX,000309,NFAT
+HGNC,7776,NFATC2,isa,FPLX,000309,NFAT
+HGNC,7777,NFATC3,isa,FPLX,000309,NFAT
+HGNC,7778,NFATC4,isa,FPLX,000309,NFAT
+HGNC,7774,NFAT5,isa,FPLX,000309,NFAT
+HGNC,4706,GYS1,isa,FPLX,000206,GYS
+HGNC,4707,GYS2,isa,FPLX,000206,GYS
+HGNC,20766,TUBA1A,isa,FPLX,000483,TUBA
+HGNC,18809,TUBA1B,isa,FPLX,000483,TUBA
+HGNC,20768,TUBA1C,isa,FPLX,000483,TUBA
+HGNC,12408,TUBA3C,isa,FPLX,000483,TUBA
+HGNC,24071,TUBA3D,isa,FPLX,000483,TUBA
+HGNC,20765,TUBA3E,isa,FPLX,000483,TUBA
+HGNC,12407,TUBA4A,isa,FPLX,000483,TUBA
+HGNC,12410,TUBA8,isa,FPLX,000483,TUBA
+HGNC,23534,TUBAL3,isa,FPLX,000483,TUBA
+HGNC,20778,TUBB,isa,FPLX,000484,TUBB
+HGNC,16257,TUBB1,isa,FPLX,000484,TUBB
+HGNC,12412,TUBB2A,isa,FPLX,000484,TUBB
+HGNC,30829,TUBB2B,isa,FPLX,000484,TUBB
+HGNC,20772,TUBB3,isa,FPLX,000484,TUBB
+HGNC,20774,TUBB4A,isa,FPLX,000484,TUBB
+HGNC,20771,TUBB4B,isa,FPLX,000484,TUBB
+HGNC,20776,TUBB6,isa,FPLX,000484,TUBB
+HGNC,12417,TUBG1,isa,FPLX,000485,TUBG
+HGNC,12419,TUBG2,isa,FPLX,000485,TUBG
+FPLX,000483,TUBA,isa,FPLX,000486,Tubulin
+FPLX,000484,TUBB,isa,FPLX,000486,Tubulin
+FPLX,000485,TUBG,isa,FPLX,000486,Tubulin
+HGNC,16811,TUBD1,isa,FPLX,000486,Tubulin
+HGNC,20775,TUBE1,isa,FPLX,000486,Tubulin
+HGNC,6190,JAK1,isa,FPLX,000266,JAK
+HGNC,6192,JAK2,isa,FPLX,000266,JAK
+HGNC,6193,JAK3,isa,FPLX,000266,JAK
+HGNC,12440,TYK2,isa,FPLX,000266,JAK
+HGNC,1706,CD8A,isa,FPLX,000090,CD8
+HGNC,1707,CD8B,isa,FPLX,000090,CD8
+HGNC,6535,LDHA,isa,FPLX,000275,LDH
+HGNC,6541,LDHB,isa,FPLX,000275,LDH
+HGNC,6544,LDHC,isa,FPLX,000275,LDH
+HGNC,10430,RPS6KA1,isa,FPLX,000329,P90RSK
+HGNC,10431,RPS6KA2,isa,FPLX,000329,P90RSK
+HGNC,10432,RPS6KA3,isa,FPLX,000329,P90RSK
+HGNC,10433,RPS6KA4,isa,FPLX,000329,P90RSK
+HGNC,10434,RPS6KA5,isa,FPLX,000329,P90RSK
+HGNC,10435,RPS6KA6,isa,FPLX,000329,P90RSK
+HGNC,10436,RPS6KB1,isa,FPLX,000328,P70S6K
+HGNC,10437,RPS6KB2,isa,FPLX,000328,P70S6K
+FPLX,000329,P90RSK,isa,FPLX,000422,RSK
+FPLX,000328,P70S6K,isa,FPLX,000422,RSK
+HGNC,9955,RELA,isa,FPLX,000313,NFkappaB_2
+HGNC,9956,RELB,isa,FPLX,000313,NFkappaB_2
+HGNC,9954,REL,isa,FPLX,000313,NFkappaB_2
+HGNC,7794,NFKB1,isa,FPLX,000312,NFkappaB_1
+HGNC,7795,NFKB2,isa,FPLX,000312,NFkappaB_1
+FPLX,000312,NFkappaB_1,partof,FPLX,000311,NFkappaB
+FPLX,000313,NFkappaB_2,partof,FPLX,000311,NFkappaB
+HGNC,11847,TLR1,isa,FPLX,000472,TLR
+HGNC,11848,TLR2,isa,FPLX,000472,TLR
+HGNC,11849,TLR3,isa,FPLX,000472,TLR
+HGNC,11850,TLR4,isa,FPLX,000472,TLR
+HGNC,11851,TLR5,isa,FPLX,000472,TLR
+HGNC,16711,TLR6,isa,FPLX,000472,TLR
+HGNC,15631,TLR7,isa,FPLX,000472,TLR
+HGNC,15632,TLR8,isa,FPLX,000472,TLR
+HGNC,15633,TLR9,isa,FPLX,000472,TLR
+HGNC,15634,TLR10,isa,FPLX,000472,TLR
+HGNC,11110,ARID1A,partof,FPLX,000457,SWI_SNF
+HGNC,18040,ARID1B,partof,FPLX,000457,SWI_SNF
+HGNC,11097,SMARCA1,partof,FPLX,000457,SWI_SNF
+HGNC,11098,SMARCA2,partof,FPLX,000457,SWI_SNF
+HGNC,11100,SMARCA4,partof,FPLX,000457,SWI_SNF
+HGNC,11101,SMARCA5,partof,FPLX,000457,SWI_SNF
+HGNC,11103,SMARCB1,partof,FPLX,000457,SWI_SNF
+HGNC,11104,SMARCC1,partof,FPLX,000457,SWI_SNF
+HGNC,11105,SMARCC2,partof,FPLX,000457,SWI_SNF
+HGNC,11106,SMARCD1,partof,FPLX,000457,SWI_SNF
+HGNC,11107,SMARCD2,partof,FPLX,000457,SWI_SNF
+HGNC,11108,SMARCD3,partof,FPLX,000457,SWI_SNF
+HGNC,11109,SMARCE1,partof,FPLX,000457,SWI_SNF
+HGNC,24124,ACTL6A,partof,FPLX,000457,SWI_SNF
+HGNC,160,ACTL6B,partof,FPLX,000457,SWI_SNF
+HGNC,11099,HLTF,partof,FPLX,000457,SWI_SNF
+HGNC,1067,BMP1,isa,FPLX,000067,BMP
+HGNC,1069,BMP2,isa,FPLX,000067,BMP
+HGNC,1070,BMP3,isa,FPLX,000067,BMP
+HGNC,1071,BMP4,isa,FPLX,000067,BMP
+HGNC,1072,BMP5,isa,FPLX,000067,BMP
+HGNC,1073,BMP6,isa,FPLX,000067,BMP
+HGNC,1074,BMP7,isa,FPLX,000067,BMP
+HGNC,21650,BMP8A,isa,FPLX,000067,BMP
+HGNC,1075,BMP8B,isa,FPLX,000067,BMP
+HGNC,20869,BMP10,isa,FPLX,000067,BMP
+HGNC,1068,BMP15,isa,FPLX,000067,BMP
+HGNC,5969,IL12A,isa,FPLX,000253,IL12
+HGNC,5970,IL12B,isa,FPLX,000253,IL12
+HGNC,5991,IL1A,isa,FPLX,000252,IL1
+HGNC,5992,IL1B,isa,FPLX,000252,IL1
+HGNC,11179,SOD1,isa,FPLX,000447,SOD
+HGNC,11180,SOD2,isa,FPLX,000447,SOD
+HGNC,11181,SOD3,isa,FPLX,000447,SOD
+HGNC,12362,TSC1,isa,FPLX,000482,TSC
+HGNC,12363,TSC2,isa,FPLX,000482,TSC
+HGNC,3819,FOXO1,isa,FPLX,000174,FOXO
+HGNC,3821,FOXO3,isa,FPLX,000174,FOXO
+HGNC,7139,FOXO4,isa,FPLX,000174,FOXO
+HGNC,24814,FOXO6,isa,FPLX,000174,FOXO
+HGNC,7155,MMP1,isa,FPLX,000291,MMP
+HGNC,7166,MMP2,isa,FPLX,000291,MMP
+HGNC,7173,MMP3,isa,FPLX,000291,MMP
+HGNC,7174,MMP7,isa,FPLX,000291,MMP
+HGNC,7175,MMP8,isa,FPLX,000291,MMP
+HGNC,7176,MMP9,isa,FPLX,000291,MMP
+HGNC,7156,MMP10,isa,FPLX,000291,MMP
+HGNC,7157,MMP11,isa,FPLX,000291,MMP
+HGNC,7158,MMP12,isa,FPLX,000291,MMP
+HGNC,7159,MMP13,isa,FPLX,000291,MMP
+HGNC,7160,MMP14,isa,FPLX,000291,MMP
+HGNC,7161,MMP15,isa,FPLX,000291,MMP
+HGNC,7162,MMP16,isa,FPLX,000291,MMP
+HGNC,7163,MMP17,isa,FPLX,000291,MMP
+HGNC,7165,MMP19,isa,FPLX,000291,MMP
+HGNC,7167,MMP20,isa,FPLX,000291,MMP
+HGNC,14357,MMP21,isa,FPLX,000291,MMP
+HGNC,7171,MMP23B,isa,FPLX,000291,MMP
+HGNC,7172,MMP24,isa,FPLX,000291,MMP
+HGNC,14246,MMP25,isa,FPLX,000291,MMP
+HGNC,14249,MMP26,isa,FPLX,000291,MMP
+HGNC,14250,MMP27,isa,FPLX,000291,MMP
+HGNC,14366,MMP28,isa,FPLX,000291,MMP
+HGNC,84,ACACA,partof,FPLX,000005,ACC
+HGNC,85,ACACB,partof,FPLX,000005,ACC
+HGNC,6838,MAP1LC3A,isa,FPLX,000280,MAP1LC3
+HGNC,13352,MAP1LC3B,isa,FPLX,000280,MAP1LC3
+HGNC,34390,MAP1LC3B2,isa,FPLX,000280,MAP1LC3
+HGNC,13353,MAP1LC3C,isa,FPLX,000280,MAP1LC3
+HGNC,5417,IFNA1,isa,FPLX,000246,IFNA
+HGNC,5423,IFNA2,isa,FPLX,000246,IFNA
+HGNC,5425,IFNA4,isa,FPLX,000246,IFNA
+HGNC,5426,IFNA5,isa,FPLX,000246,IFNA
+HGNC,5427,IFNA6,isa,FPLX,000246,IFNA
+HGNC,5428,IFNA7,isa,FPLX,000246,IFNA
+HGNC,5429,IFNA8,isa,FPLX,000246,IFNA
+HGNC,5418,IFNA10,isa,FPLX,000246,IFNA
+HGNC,5419,IFNA13,isa,FPLX,000246,IFNA
+HGNC,5420,IFNA14,isa,FPLX,000246,IFNA
+HGNC,5421,IFNA16,isa,FPLX,000246,IFNA
+HGNC,5422,IFNA17,isa,FPLX,000246,IFNA
+HGNC,5424,IFNA21,isa,FPLX,000246,IFNA
+HGNC,5434,IFNB1,isa,FPLX,000247,IFNB
+FPLX,000246,IFNA,isa,FPLX,000262,Interferon
+FPLX,000247,IFNB,isa,FPLX,000262,Interferon
+HGNC,21714,IFNK,isa,FPLX,000262,Interferon
+HGNC,5448,IFNW1,isa,FPLX,000262,Interferon
+HGNC,11916,TNFRSF1A,isa,FPLX,000137,Death_receptor
+HGNC,11917,TNFRSF1B,isa,FPLX,000137,Death_receptor
+HGNC,11904,TNFRSF10A,isa,FPLX,000137,Death_receptor
+HGNC,11905,TNFRSF10B,isa,FPLX,000137,Death_receptor
+HGNC,11906,TNFRSF10C,isa,FPLX,000137,Death_receptor
+HGNC,11907,TNFRSF10D,isa,FPLX,000137,Death_receptor
+HGNC,11920,FAS,isa,FPLX,000137,Death_receptor
+HGNC,11916,TNFRSF1A,isa,FPLX,000475,TNFRSF
+HGNC,11917,TNFRSF1B,isa,FPLX,000475,TNFRSF
+HGNC,11918,TNFRSF4,isa,FPLX,000475,TNFRSF
+HGNC,11923,TNFRSF8,isa,FPLX,000475,TNFRSF
+HGNC,11924,TNFRSF9,isa,FPLX,000475,TNFRSF
+HGNC,11904,TNFRSF10A,isa,FPLX,000475,TNFRSF
+HGNC,11905,TNFRSF10B,isa,FPLX,000475,TNFRSF
+HGNC,11906,TNFRSF10C,isa,FPLX,000475,TNFRSF
+HGNC,11907,TNFRSF10D,isa,FPLX,000475,TNFRSF
+HGNC,11908,TNFRSF11A,isa,FPLX,000475,TNFRSF
+HGNC,11909,TNFRSF11B,isa,FPLX,000475,TNFRSF
+HGNC,18152,TNFRSF12A,isa,FPLX,000475,TNFRSF
+HGNC,18153,TNFRSF13B,isa,FPLX,000475,TNFRSF
+HGNC,17755,TNFRSF13C,isa,FPLX,000475,TNFRSF
+HGNC,11912,TNFRSF14,isa,FPLX,000475,TNFRSF
+HGNC,11913,TNFRSF17,isa,FPLX,000475,TNFRSF
+HGNC,11914,TNFRSF18,isa,FPLX,000475,TNFRSF
+HGNC,11915,TNFRSF19,isa,FPLX,000475,TNFRSF
+HGNC,13469,TNFRSF21,isa,FPLX,000475,TNFRSF
+HGNC,11910,TNFRSF25,isa,FPLX,000475,TNFRSF
+HGNC,3665,FGF1,isa,FPLX,000167,FGF
+HGNC,3676,FGF2,isa,FPLX,000167,FGF
+HGNC,3681,FGF3,isa,FPLX,000167,FGF
+HGNC,3682,FGF4,isa,FPLX,000167,FGF
+HGNC,3683,FGF5,isa,FPLX,000167,FGF
+HGNC,3684,FGF6,isa,FPLX,000167,FGF
+HGNC,3685,FGF7,isa,FPLX,000167,FGF
+HGNC,3686,FGF8,isa,FPLX,000167,FGF
+HGNC,3687,FGF9,isa,FPLX,000167,FGF
+HGNC,3666,FGF10,isa,FPLX,000167,FGF
+HGNC,3667,FGF11,isa,FPLX,000167,FGF
+HGNC,3668,FGF12,isa,FPLX,000167,FGF
+HGNC,3670,FGF13,isa,FPLX,000167,FGF
+HGNC,3671,FGF14,isa,FPLX,000167,FGF
+HGNC,3672,FGF16,isa,FPLX,000167,FGF
+HGNC,3673,FGF17,isa,FPLX,000167,FGF
+HGNC,3674,FGF18,isa,FPLX,000167,FGF
+HGNC,3675,FGF19,isa,FPLX,000167,FGF
+HGNC,3677,FGF20,isa,FPLX,000167,FGF
+HGNC,3678,FGF21,isa,FPLX,000167,FGF
+HGNC,3679,FGF22,isa,FPLX,000167,FGF
+HGNC,3680,FGF23,isa,FPLX,000167,FGF
+HGNC,12774,WNT1,isa,FPLX,000497,Wnt
+HGNC,12780,WNT2,isa,FPLX,000497,Wnt
+HGNC,12781,WNT2B,isa,FPLX,000497,Wnt
+HGNC,12782,WNT3,isa,FPLX,000497,Wnt
+HGNC,15983,WNT3A,isa,FPLX,000497,Wnt
+HGNC,12783,WNT4,isa,FPLX,000497,Wnt
+HGNC,12784,WNT5A,isa,FPLX,000497,Wnt
+HGNC,16265,WNT5B,isa,FPLX,000497,Wnt
+HGNC,12785,WNT6,isa,FPLX,000497,Wnt
+HGNC,12786,WNT7A,isa,FPLX,000497,Wnt
+HGNC,12787,WNT7B,isa,FPLX,000497,Wnt
+HGNC,12788,WNT8A,isa,FPLX,000497,Wnt
+HGNC,12789,WNT8B,isa,FPLX,000497,Wnt
+HGNC,12778,WNT9A,isa,FPLX,000497,Wnt
+HGNC,12779,WNT9B,isa,FPLX,000497,Wnt
+HGNC,13829,WNT10A,isa,FPLX,000497,Wnt
+HGNC,12775,WNT10B,isa,FPLX,000497,Wnt
+HGNC,12776,WNT11,isa,FPLX,000497,Wnt
+HGNC,16267,WNT16,isa,FPLX,000497,Wnt
+HGNC,646,ARAF,isa,FPLX,000399,RAF
+HGNC,1097,BRAF,isa,FPLX,000399,RAF
+HGNC,9829,RAF1,isa,FPLX,000399,RAF
+FPLX,000399,RAF,isa,FPLX,000282,MAP3K
+HGNC,6848,MAP3K1,isa,FPLX,000282,MAP3K
+HGNC,6854,MAP3K2,isa,FPLX,000282,MAP3K
+HGNC,6855,MAP3K3,isa,FPLX,000282,MAP3K
+HGNC,6856,MAP3K4,isa,FPLX,000282,MAP3K
+HGNC,6857,MAP3K5,isa,FPLX,000282,MAP3K
+HGNC,6858,MAP3K6,isa,FPLX,000282,MAP3K
+HGNC,6859,MAP3K7,isa,FPLX,000282,MAP3K
+HGNC,6860,MAP3K8,isa,FPLX,000282,MAP3K
+HGNC,6861,MAP3K9,isa,FPLX,000282,MAP3K
+HGNC,6849,MAP3K10,isa,FPLX,000282,MAP3K
+HGNC,6850,MAP3K11,isa,FPLX,000282,MAP3K
+HGNC,6851,MAP3K12,isa,FPLX,000282,MAP3K
+HGNC,6852,MAP3K13,isa,FPLX,000282,MAP3K
+HGNC,6853,MAP3K14,isa,FPLX,000282,MAP3K
+HGNC,31689,MAP3K15,isa,FPLX,000282,MAP3K
+FPLX,000458,TAOK,isa,FPLX,000282,MAP3K
+HGNC,29259,TAOK1,isa,FPLX,000458,TAOK
+HGNC,16835,TAOK2,isa,FPLX,000458,TAOK
+HGNC,18133,TAOK3,isa,FPLX,000458,TAOK
+HGNC,26249,MAP3K19,isa,FPLX,000282,MAP3K
+HGNC,17797,MAP3K20,isa,FPLX,000282,MAP3K
+HGNC,29798,MAP3K21,isa,FPLX,000282,MAP3K
+HGNC,1100,BRCA1,isa,FPLX,000071,BRCA
+HGNC,1101,BRCA2,isa,FPLX,000071,BRCA
+HGNC,19700,CNKSR1,isa,FPLX,000106,CNKSR
+HGNC,19701,CNKSR2,isa,FPLX,000106,CNKSR
+HGNC,3064,DUSP1,isa,FPLX,000144,DUSP
+HGNC,3068,DUSP2,isa,FPLX,000144,DUSP
+HGNC,3069,DUSP3,isa,FPLX,000144,DUSP
+HGNC,3070,DUSP4,isa,FPLX,000144,DUSP
+HGNC,3071,DUSP5,isa,FPLX,000144,DUSP
+HGNC,3072,DUSP6,isa,FPLX,000144,DUSP
+HGNC,3488,ETS1,isa,FPLX,000163,ETS
+HGNC,3489,ETS2,isa,FPLX,000163,ETS
+HGNC,30380,EXOC1,partof,FPLX,000164,EXOC
+HGNC,24968,EXOC2,partof,FPLX,000164,EXOC
+HGNC,30378,EXOC3,partof,FPLX,000164,EXOC
+HGNC,30389,EXOC4,partof,FPLX,000164,EXOC
+HGNC,10696,EXOC5,partof,FPLX,000164,EXOC
+HGNC,23196,EXOC6,partof,FPLX,000164,EXOC
+HGNC,23214,EXOC7,partof,FPLX,000164,EXOC
+HGNC,24659,EXOC8,partof,FPLX,000164,EXOC
+HGNC,3582,FANCA,isa,FPLX,000166,FANC
+HGNC,3583,FANCB,isa,FPLX,000166,FANC
+HGNC,3584,FANCC,isa,FPLX,000166,FANC
+HGNC,1101,BRCA2,isa,FPLX,000166,FANC
+HGNC,3585,FANCD2,isa,FPLX,000166,FANC
+HGNC,3586,FANCE,isa,FPLX,000166,FANC
+HGNC,3587,FANCF,isa,FPLX,000166,FANC
+HGNC,3588,FANCG,isa,FPLX,000166,FANC
+HGNC,25568,FANCI,isa,FPLX,000166,FANC
+HGNC,20473,BRIP1,isa,FPLX,000166,FANC
+HGNC,20748,FANCL,isa,FPLX,000166,FANC
+HGNC,23168,FANCM,isa,FPLX,000166,FANC
+HGNC,26144,PALB2,isa,FPLX,000166,FANC
+HGNC,9820,RAD51C,isa,FPLX,000166,FANC
+HGNC,23845,SLX4,isa,FPLX,000166,FANC
+HGNC,3436,ERCC4,isa,FPLX,000166,FANC
+HGNC,9817,RAD51,isa,FPLX,000166,FANC
+HGNC,1100,BRCA1,isa,FPLX,000166,FANC
+HGNC,25009,UBE2T,isa,FPLX,000166,FANC
+HGNC,12829,XRCC2,isa,FPLX,000166,FANC
+HGNC,3782,FNTA,partof,FPLX,000172,FNT
+HGNC,3785,FNTB,partof,FPLX,000172,FNT
+HGNC,6407,KRAS,isa,FPLX,000404,RAS
+HGNC,5173,HRAS,isa,FPLX,000404,RAS
+HGNC,7989,NRAS,isa,FPLX,000404,RAS
+HGNC,6465,KSR1,isa,FPLX,000272,KSR
+HGNC,18610,KSR2,isa,FPLX,000272,KSR
+HGNC,6840,MAP2K1,isa,FPLX,000286,MEK
+HGNC,6842,MAP2K2,isa,FPLX,000286,MEK
+FPLX,000286,MEK,isa,FPLX,000281,MAP2K
+HGNC,6843,MAP2K3,isa,FPLX,000281,MAP2K
+HGNC,6844,MAP2K4,isa,FPLX,000281,MAP2K
+HGNC,6845,MAP2K5,isa,FPLX,000281,MAP2K
+HGNC,6846,MAP2K6,isa,FPLX,000281,MAP2K
+HGNC,6847,MAP2K7,isa,FPLX,000281,MAP2K
+HGNC,6944,MCM2,isa,FPLX,000284,MCM
+HGNC,6945,MCM3,isa,FPLX,000284,MCM
+HGNC,6947,MCM4,isa,FPLX,000284,MCM
+HGNC,6948,MCM5,isa,FPLX,000284,MCM
+HGNC,6949,MCM6,isa,FPLX,000284,MCM
+HGNC,6950,MCM7,isa,FPLX,000284,MCM
+HGNC,16147,MCM8,isa,FPLX,000284,MCM
+HGNC,21484,MCM9,isa,FPLX,000284,MCM
+HGNC,26368,MCMDC2,isa,FPLX,000284,MCM
+HGNC,8590,PAK1,isa,FPLX,000330,PAK
+HGNC,8591,PAK2,isa,FPLX,000330,PAK
+HGNC,8592,PAK3,isa,FPLX,000330,PAK
+HGNC,16059,PAK4,isa,FPLX,000330,PAK
+HGNC,15916,PAK5,isa,FPLX,000330,PAK
+HGNC,16061,PAK6,isa,FPLX,000330,PAK
+HGNC,9801,RAC1,isa,FPLX,000398,RAC
+HGNC,9802,RAC2,isa,FPLX,000398,RAC
+HGNC,9803,RAC3,isa,FPLX,000398,RAC
+HGNC,672,RHOG,isa,FPLX,000398,RAC
+HGNC,9839,RALA,isa,FPLX,000400,RAL
+HGNC,9840,RALB,isa,FPLX,000400,RAL
+HGNC,4568,RAPGEF1,isa,FPLX,000402,RAPGEF
+HGNC,16854,RAPGEF2,isa,FPLX,000402,RAPGEF
+HGNC,9871,RASA1,isa,FPLX,000405,RASA
+HGNC,9872,RASA2,isa,FPLX,000405,RASA
+HGNC,20331,RASA3,isa,FPLX,000405,RASA
+HGNC,9873,RASAL1,isa,FPLX,000406,RASAL
+HGNC,9874,RASAL2,isa,FPLX,000406,RASAL
+HGNC,26129,RASAL3,isa,FPLX,000406,RASAL
+HGNC,9875,RASGRF1,isa,FPLX,000408,RASGRF
+HGNC,9876,RASGRF2,isa,FPLX,000408,RASGRF
+HGNC,9878,RASGRP1,isa,FPLX,000409,RASGRP
+HGNC,9879,RASGRP2,isa,FPLX,000409,RASGRP
+HGNC,14545,RASGRP3,isa,FPLX,000409,RASGRP
+HGNC,18958,RASGRP4,isa,FPLX,000409,RASGRP
+HGNC,9882,RASSF1,isa,FPLX,000410,RASSF
+HGNC,9883,RASSF2,isa,FPLX,000410,RASSF
+HGNC,14271,RASSF3,isa,FPLX,000410,RASSF
+HGNC,20793,RASSF4,isa,FPLX,000410,RASSF
+HGNC,17609,RASSF5,isa,FPLX,000410,RASSF
+HGNC,20796,RASSF6,isa,FPLX,000410,RASSF
+HGNC,1166,RASSF7,isa,FPLX,000410,RASSF
+HGNC,13232,RASSF8,isa,FPLX,000410,RASSF
+HGNC,15739,RASSF9,isa,FPLX,000410,RASSF
+HGNC,33984,RASSF10,isa,FPLX,000410,RASSF
+HGNC,30281,RGL1,isa,FPLX,000413,RGL
+HGNC,9769,RGL2,isa,FPLX,000413,RGL
+HGNC,30282,RGL3,isa,FPLX,000413,RGL
+HGNC,667,RHOA,isa,FPLX,000414,RHO
+HGNC,668,RHOB,isa,FPLX,000414,RHO
+HGNC,669,RHOC,isa,FPLX,000414,RHO
+HGNC,10251,ROCK1,isa,FPLX,000419,ROCK
+HGNC,10252,ROCK2,isa,FPLX,000419,ROCK
+HGNC,10840,SHC1,isa,FPLX,000432,SHC
+HGNC,29869,SHC2,isa,FPLX,000432,SHC
+HGNC,18181,SHC3,isa,FPLX,000432,SHC
+HGNC,16743,SHC4,isa,FPLX,000432,SHC
+HGNC,11187,SOS1,isa,FPLX,000448,SOS
+HGNC,11188,SOS2,isa,FPLX,000448,SOS
+HGNC,11269,SPRY1,isa,FPLX,000450,SPRY
+HGNC,11270,SPRY2,isa,FPLX,000450,SPRY
+HGNC,11271,SPRY3,isa,FPLX,000450,SPRY
+HGNC,15533,SPRY4,isa,FPLX,000450,SPRY
+HGNC,11749,TFDP1,isa,FPLX,000464,TFDP
+HGNC,11751,TFDP2,isa,FPLX,000464,TFDP
+HGNC,11805,TIAM1,isa,FPLX,000470,TIAM
+HGNC,11806,TIAM2,isa,FPLX,000470,TIAM
+HGNC,20249,SPRED1,isa,FPLX,000449,SPRED
+HGNC,17722,SPRED2,isa,FPLX,000449,SPRED
+HGNC,31041,SPRED3,isa,FPLX,000449,SPRED
+HGNC,1885,CGA,partof,FPLX,000219,hCG
+HGNC,1886,CGB3,partof,FPLX,000219,hCG
+HGNC,10513,SAA1,isa,FPLX,000428,SAA
+HGNC,10514,SAA2,isa,FPLX,000428,SAA
+HGNC,10516,SAA4,isa,FPLX,000428,SAA
+HGNC,6873,MAPK11,isa,FPLX,000326,p38
+HGNC,6874,MAPK12,isa,FPLX,000326,p38
+HGNC,6875,MAPK13,isa,FPLX,000326,p38
+HGNC,6876,MAPK14,isa,FPLX,000326,p38
+FPLX,000326,p38,isa,FPLX,000283,MAPK
+HGNC,10773,SFN,isa,FPLX,000323,p14_3_3
+HGNC,12849,YWHAB,isa,FPLX,000323,p14_3_3
+HGNC,12851,YWHAE,isa,FPLX,000323,p14_3_3
+HGNC,12852,YWHAG,isa,FPLX,000323,p14_3_3
+HGNC,12853,YWHAH,isa,FPLX,000323,p14_3_3
+HGNC,12854,YWHAQ,isa,FPLX,000323,p14_3_3
+HGNC,12855,YWHAZ,isa,FPLX,000323,p14_3_3
+HGNC,59,ABCC8,isa,FPLX,000456,Sulfonylurea_receptor
+HGNC,60,ABCC9,isa,FPLX,000456,Sulfonylurea_receptor
+HGNC,87,ACAD8,isa,FPLX,000004,ACAD
+HGNC,21497,ACAD9,isa,FPLX,000004,ACAD
+HGNC,88,ACADL,isa,FPLX,000004,ACAD
+HGNC,89,ACADM,isa,FPLX,000004,ACAD
+HGNC,90,ACADS,isa,FPLX,000004,ACAD
+HGNC,92,ACADVL,isa,FPLX,000004,ACAD
+HGNC,21597,ACAD10,isa,FPLX,000004,ACAD
+HGNC,30211,ACAD11,isa,FPLX,000004,ACAD
+HGNC,91,ACADSB,isa,FPLX,000004,ACAD
+HGNC,4189,GCDH,isa,FPLX,000004,ACAD
+HGNC,6186,IVD,isa,FPLX,000004,ACAD
+HGNC,10996,SLC27A2,isa,FPLX,000006,Acetyl_CoA_synthetase
+HGNC,3569,ACSL1,isa,FPLX,000006,Acetyl_CoA_synthetase
+HGNC,3570,ACSL3,isa,FPLX,000006,Acetyl_CoA_synthetase
+HGNC,3571,ACSL4,isa,FPLX,000006,Acetyl_CoA_synthetase
+HGNC,16526,ACSL5,isa,FPLX,000006,Acetyl_CoA_synthetase
+HGNC,16496,ACSL6,isa,FPLX,000006,Acetyl_CoA_synthetase
+HGNC,119,ACOX1,isa,FPLX,000007,ACOX
+HGNC,120,ACOX2,isa,FPLX,000007,ACOX
+HGNC,121,ACOX3,isa,FPLX,000007,ACOX
+HGNC,25621,ACOXL,isa,FPLX,000007,ACOX
+HGNC,3569,ACSL1,isa,FPLX,000008,ACSL
+HGNC,3570,ACSL3,isa,FPLX,000008,ACSL
+HGNC,3571,ACSL4,isa,FPLX,000008,ACSL
+HGNC,16526,ACSL5,isa,FPLX,000008,ACSL
+HGNC,16496,ACSL6,isa,FPLX,000008,ACSL
+HGNC,163,ACTN1,isa,FPLX,000014,ACTN
+HGNC,164,ACTN2,isa,FPLX,000014,ACTN
+HGNC,165,ACTN3,isa,FPLX,000014,ACTN
+HGNC,166,ACTN4,isa,FPLX,000014,ACTN
+HGNC,232,ADCY1,isa,FPLX,000017,ADCY
+HGNC,233,ADCY2,isa,FPLX,000017,ADCY
+HGNC,234,ADCY3,isa,FPLX,000017,ADCY
+HGNC,235,ADCY4,isa,FPLX,000017,ADCY
+HGNC,236,ADCY5,isa,FPLX,000017,ADCY
+HGNC,237,ADCY6,isa,FPLX,000017,ADCY
+HGNC,238,ADCY7,isa,FPLX,000017,ADCY
+HGNC,239,ADCY8,isa,FPLX,000017,ADCY
+HGNC,240,ADCY9,isa,FPLX,000017,ADCY
+HGNC,21285,ADCY10,isa,FPLX,000017,ADCY
+HGNC,249,ADH1A,isa,FPLX,000018,ADH
+HGNC,250,ADH1B,isa,FPLX,000018,ADH
+HGNC,251,ADH1C,isa,FPLX,000018,ADH
+HGNC,252,ADH4,isa,FPLX,000018,ADH
+HGNC,253,ADH5,isa,FPLX,000018,ADH
+HGNC,255,ADH6,isa,FPLX,000018,ADH
+HGNC,256,ADH7,isa,FPLX,000018,ADH
+HGNC,16354,ADHFE1,isa,FPLX,000018,ADH
+HGNC,277,ADRA1A,isa,FPLX,000019,ADRA
+HGNC,278,ADRA1B,isa,FPLX,000019,ADRA
+HGNC,280,ADRA1D,isa,FPLX,000019,ADRA
+HGNC,281,ADRA2A,isa,FPLX,000019,ADRA
+HGNC,282,ADRA2B,isa,FPLX,000019,ADRA
+HGNC,283,ADRA2C,isa,FPLX,000019,ADRA
+HGNC,281,ADRA2A,isa,FPLX,000020,ADRA2
+HGNC,282,ADRA2B,isa,FPLX,000020,ADRA2
+HGNC,283,ADRA2C,isa,FPLX,000020,ADRA2
+HGNC,285,ADRB1,isa,FPLX,000021,ADRB
+HGNC,286,ADRB2,isa,FPLX,000021,ADRB
+HGNC,288,ADRB3,isa,FPLX,000021,ADRB
+HGNC,289,GRK2,isa,FPLX,000022,ADRBK
+HGNC,290,GRK3,isa,FPLX,000022,ADRBK
+HGNC,402,ALDH1A1,isa,FPLX,000024,ALDH
+HGNC,15472,ALDH1A2,isa,FPLX,000024,ALDH
+HGNC,409,ALDH1A3,isa,FPLX,000024,ALDH
+HGNC,404,ALDH2,isa,FPLX,000024,ALDH
+HGNC,405,ALDH3A1,isa,FPLX,000024,ALDH
+HGNC,403,ALDH3A2,isa,FPLX,000024,ALDH
+HGNC,410,ALDH3B1,isa,FPLX,000024,ALDH
+HGNC,408,ALDH5A1,isa,FPLX,000024,ALDH
+HGNC,877,ALDH7A1,isa,FPLX,000024,ALDH
+HGNC,412,ALDH9A1,isa,FPLX,000024,ALDH
+HGNC,414,ALDOA,isa,FPLX,000025,ALDO
+HGNC,417,ALDOB,isa,FPLX,000025,ALDO
+HGNC,418,ALDOC,isa,FPLX,000025,ALDO
+HGNC,600,APOA1,isa,FPLX,000051,APOA
+HGNC,601,APOA2,isa,FPLX,000051,APOA
+HGNC,602,APOA4,isa,FPLX,000051,APOA
+HGNC,17288,APOA5,isa,FPLX,000051,APOA
+FPLX,000051,APOA,isa,FPLX,000052,Apolipoprotein
+HGNC,613,APOE,isa,FPLX,000052,Apolipoprotein
+HGNC,711,ARRB1,isa,FPLX,000055,ARRB
+HGNC,712,ARRB2,isa,FPLX,000055,ARRB
+HGNC,16489,ATG4A,isa,FPLX,000056,ATG4
+HGNC,20790,ATG4B,isa,FPLX,000056,ATG4
+HGNC,16040,ATG4C,isa,FPLX,000056,ATG4
+HGNC,20789,ATG4D,isa,FPLX,000056,ATG4
+HGNC,903,AXIN1,isa,FPLX,000062,AXIN
+HGNC,904,AXIN2,isa,FPLX,000062,AXIN
+HGNC,590,BIRC2,isa,FPLX,000066,BIRC
+HGNC,591,BIRC3,isa,FPLX,000066,BIRC
+HGNC,593,BIRC5,isa,FPLX,000066,BIRC
+HGNC,13516,BIRC6,isa,FPLX,000066,BIRC
+HGNC,13702,BIRC7,isa,FPLX,000066,BIRC
+HGNC,14878,BIRC8,isa,FPLX,000066,BIRC
+HGNC,7634,NAIP,isa,FPLX,000066,BIRC
+HGNC,592,XIAP,isa,FPLX,000066,BIRC
+HGNC,4214,GDF1,isa,FPLX,000067,BMP
+HGNC,4217,GDF2,isa,FPLX,000067,BMP
+HGNC,4218,GDF3,isa,FPLX,000067,BMP
+HGNC,4220,GDF5,isa,FPLX,000067,BMP
+HGNC,4221,GDF6,isa,FPLX,000067,BMP
+HGNC,4222,GDF7,isa,FPLX,000067,BMP
+FPLX,000069,BMP_receptor_type_I,isa,FPLX,000068,BMP_receptor
+FPLX,000070,BMP_receptor_type_II,isa,FPLX,000068,BMP_receptor
+HGNC,171,ACVR1,isa,FPLX,000069,BMP_receptor_type_I
+HGNC,1076,BMPR1A,isa,FPLX,000069,BMP_receptor_type_I
+HGNC,1077,BMPR1B,isa,FPLX,000069,BMP_receptor_type_I
+HGNC,173,ACVR2A,isa,FPLX,000070,BMP_receptor_type_II
+HGNC,174,ACVR2B,isa,FPLX,000070,BMP_receptor_type_II
+HGNC,1078,BMPR2,isa,FPLX,000070,BMP_receptor_type_II
+HGNC,1442,CALM1,isa,FPLX,000075,CALM
+HGNC,1445,CALM2,isa,FPLX,000075,CALM
+HGNC,1449,CALM3,isa,FPLX,000075,CALM
+HGNC,1459,CAMK1,isa,FPLX,000076,CAMK
+HGNC,19341,CAMK1D,isa,FPLX,000076,CAMK
+HGNC,14585,CAMK1G,isa,FPLX,000076,CAMK
+HGNC,1460,CAMK2A,isa,FPLX,000078,CAMK2_family
+HGNC,1461,CAMK2B,isa,FPLX,000078,CAMK2_family
+HGNC,1462,CAMK2D,isa,FPLX,000078,CAMK2_family
+HGNC,1463,CAMK2G,isa,FPLX,000078,CAMK2_family
+HGNC,1464,CAMK4,isa,FPLX,000076,CAMK
+FPLX,000078,CAMK2_family,isa,FPLX,000076,CAMK
+HGNC,1476,CAPN1,isa,FPLX,000079,CAPN
+HGNC,1477,CAPN10,isa,FPLX,000079,CAPN
+HGNC,1478,CAPN11,isa,FPLX,000079,CAPN
+HGNC,13249,CAPN12,isa,FPLX,000079,CAPN
+HGNC,16663,CAPN13,isa,FPLX,000079,CAPN
+HGNC,16664,CAPN14,isa,FPLX,000079,CAPN
+HGNC,1479,CAPN2,isa,FPLX,000079,CAPN
+HGNC,1480,CAPN3,isa,FPLX,000079,CAPN
+HGNC,1482,CAPN5,isa,FPLX,000079,CAPN
+HGNC,1483,CAPN6,isa,FPLX,000079,CAPN
+HGNC,1484,CAPN7,isa,FPLX,000079,CAPN
+HGNC,1486,CAPN9,isa,FPLX,000079,CAPN
+HGNC,11182,CAPN15,isa,FPLX,000079,CAPN
+HGNC,1485,CAPN8,isa,FPLX,000079,CAPN
+HGNC,1863,CES1,isa,FPLX,000080,Carboxylesterase
+HGNC,1864,CES2,isa,FPLX,000080,Carboxylesterase
+HGNC,1865,CES3,isa,FPLX,000080,Carboxylesterase
+HGNC,26741,CES4A,isa,FPLX,000080,Carboxylesterase
+HGNC,26459,CES5A,isa,FPLX,000080,Carboxylesterase
+HGNC,1527,CAV1,isa,FPLX,000083,CAV
+HGNC,1528,CAV2,isa,FPLX,000083,CAV
+HGNC,1529,CAV3,isa,FPLX,000083,CAV
+HGNC,3619,FCGR3A,isa,FPLX,000086,CD16
+HGNC,3620,FCGR3B,isa,FPLX,000086,CD16
+HGNC,3616,FCGR2A,isa,FPLX,000088,CD32
+HGNC,3618,FCGR2B,isa,FPLX,000088,CD32
+HGNC,15626,FCGR2C,isa,FPLX,000088,CD32
+HGNC,3613,FCGR1A,isa,FPLX,000089,CD64
+HGNC,3614,FCGR1B,isa,FPLX,000089,CD64
+HGNC,1725,CDC25A,isa,FPLX,000091,CDC25
+HGNC,1726,CDC25B,isa,FPLX,000091,CDC25
+HGNC,1727,CDC25C,isa,FPLX,000091,CDC25
+HGNC,1748,CDH1,isa,FPLX,000074,Cadherin
+HGNC,1749,CDH10,isa,FPLX,000074,Cadherin
+HGNC,1750,CDH11,isa,FPLX,000074,Cadherin
+HGNC,1751,CDH12,isa,FPLX,000074,Cadherin
+HGNC,1753,CDH13,isa,FPLX,000074,Cadherin
+HGNC,1754,CDH15,isa,FPLX,000074,Cadherin
+HGNC,1755,CDH16,isa,FPLX,000074,Cadherin
+HGNC,1756,CDH17,isa,FPLX,000074,Cadherin
+HGNC,1757,CDH18,isa,FPLX,000074,Cadherin
+HGNC,1758,CDH19,isa,FPLX,000074,Cadherin
+HGNC,1759,CDH2,isa,FPLX,000074,Cadherin
+HGNC,1760,CDH20,isa,FPLX,000074,Cadherin
+HGNC,13251,CDH22,isa,FPLX,000074,Cadherin
+HGNC,14265,CDH24,isa,FPLX,000074,Cadherin
+HGNC,1762,CDH3,isa,FPLX,000074,Cadherin
+HGNC,1763,CDH4,isa,FPLX,000074,Cadherin
+HGNC,1764,CDH5,isa,FPLX,000074,Cadherin
+HGNC,1765,CDH6,isa,FPLX,000074,Cadherin
+HGNC,1766,CDH7,isa,FPLX,000074,Cadherin
+HGNC,1767,CDH8,isa,FPLX,000074,Cadherin
+HGNC,1768,CDH9,isa,FPLX,000074,Cadherin
+HGNC,1833,CEBPA,isa,FPLX,000097,CEBP
+HGNC,1834,CEBPB,isa,FPLX,000097,CEBP
+HGNC,1835,CEBPD,isa,FPLX,000097,CEBP
+HGNC,1837,CEBPG,isa,FPLX,000097,CEBP
+HGNC,1836,CEBPE,isa,FPLX,000097,CEBP
+HGNC,1565,ACKR2,isa,FPLX,000100,Chemokine_receptor
+HGNC,1602,CCR1,isa,FPLX,000100,Chemokine_receptor
+HGNC,4474,CCR10,isa,FPLX,000100,Chemokine_receptor
+HGNC,1603,CCR2,isa,FPLX,000100,Chemokine_receptor
+HGNC,1604,CCR3,isa,FPLX,000100,Chemokine_receptor
+HGNC,1605,CCR4,isa,FPLX,000100,Chemokine_receptor
+HGNC,1606,CCR5,isa,FPLX,000100,Chemokine_receptor
+HGNC,1607,CCR6,isa,FPLX,000100,Chemokine_receptor
+HGNC,1608,CCR7,isa,FPLX,000100,Chemokine_receptor
+HGNC,1609,CCR8,isa,FPLX,000100,Chemokine_receptor
+HGNC,1610,CCR9,isa,FPLX,000100,Chemokine_receptor
+HGNC,1611,ACKR4,isa,FPLX,000100,Chemokine_receptor
+HGNC,1612,CCRL2,isa,FPLX,000100,Chemokine_receptor
+HGNC,2558,CX3CR1,isa,FPLX,000100,Chemokine_receptor
+HGNC,6026,CXCR1,isa,FPLX,000100,Chemokine_receptor
+HGNC,6027,CXCR2,isa,FPLX,000100,Chemokine_receptor
+HGNC,4540,CXCR3,isa,FPLX,000100,Chemokine_receptor
+HGNC,2561,CXCR4,isa,FPLX,000100,Chemokine_receptor
+HGNC,1060,CXCR5,isa,FPLX,000100,Chemokine_receptor
+HGNC,16647,CXCR6,isa,FPLX,000100,Chemokine_receptor
+HGNC,23692,ACKR3,isa,FPLX,000100,Chemokine_receptor
+HGNC,1625,XCR1,isa,FPLX,000100,Chemokine_receptor
+HGNC,108,ACHE,isa,FPLX,000101,Cholinesterase
+HGNC,983,BCHE,isa,FPLX,000101,Cholinesterase
+HGNC,1950,CHRM1,isa,FPLX,000102,CHRM
+HGNC,1951,CHRM2,isa,FPLX,000102,CHRM
+HGNC,1952,CHRM3,isa,FPLX,000102,CHRM
+HGNC,1953,CHRM4,isa,FPLX,000102,CHRM
+HGNC,1954,CHRM5,isa,FPLX,000102,CHRM
+HGNC,2197,COL1A1,isa,FPLX,000109,COL1
+HGNC,2198,COL1A2,isa,FPLX,000109,COL1
+HGNC,2202,COL4A1,isa,FPLX,000110,COL4
+HGNC,2203,COL4A2,isa,FPLX,000110,COL4
+HGNC,2204,COL4A3,isa,FPLX,000110,COL4
+HGNC,2206,COL4A4,isa,FPLX,000110,COL4
+HGNC,2207,COL4A5,isa,FPLX,000110,COL4
+HGNC,2208,COL4A6,isa,FPLX,000110,COL4
+HGNC,2209,COL5A1,isa,FPLX,000111,COL5
+HGNC,2210,COL5A2,isa,FPLX,000111,COL5
+HGNC,14864,COL5A3,isa,FPLX,000111,COL5
+HGNC,2265,COX4I1,isa,FPLX,000114,COX4
+HGNC,16232,COX4I2,isa,FPLX,000114,COX4
+HGNC,2277,COX6A1,isa,FPLX,000115,COX6A
+HGNC,2279,COX6A2,isa,FPLX,000115,COX6A
+HGNC,2280,COX6B1,isa,FPLX,000116,COX6B
+HGNC,24380,COX6B2,isa,FPLX,000116,COX6B
+HGNC,2287,COX7A1,isa,FPLX,000117,COX7A
+HGNC,2288,COX7A2,isa,FPLX,000117,COX7A
+HGNC,2291,COX7B,isa,FPLX,000118,COX7B
+HGNC,24381,COX7B2,isa,FPLX,000118,COX7B
+HGNC,2294,COX8A,isa,FPLX,000119,COX8
+HGNC,24382,COX8C,isa,FPLX,000119,COX8
+HGNC,2267,COX5A,partof,FPLX,000113,COX
+HGNC,2269,COX5B,partof,FPLX,000113,COX
+FPLX,000114,COX4,partof,FPLX,000113,COX
+FPLX,000115,COX6A,partof,FPLX,000113,COX
+FPLX,000116,COX6B,partof,FPLX,000113,COX
+FPLX,000117,COX7A,partof,FPLX,000113,COX
+FPLX,000118,COX7B,partof,FPLX,000113,COX
+FPLX,000119,COX8,partof,FPLX,000113,COX
+HGNC,2260,COX10,partof,FPLX,000113,COX
+HGNC,2261,COX11,partof,FPLX,000113,COX
+HGNC,2263,COX15,partof,FPLX,000113,COX
+HGNC,2264,COX17,partof,FPLX,000113,COX
+HGNC,304,CRISP1,isa,FPLX,000121,CRISP
+HGNC,12024,CRISP2,isa,FPLX,000121,CRISP
+HGNC,16904,CRISP3,isa,FPLX,000121,CRISP
+HGNC,2509,CTNNA1,isa,FPLX,000126,CTNNA
+HGNC,2510,CTNNA2,isa,FPLX,000126,CTNNA
+HGNC,2511,CTNNA3,isa,FPLX,000126,CTNNA
+HGNC,2551,CUL1,isa,FPLX,000127,CUL
+HGNC,2552,CUL2,isa,FPLX,000127,CUL
+HGNC,2553,CUL3,isa,FPLX,000127,CUL
+HGNC,2554,CUL4A,isa,FPLX,000127,CUL
+HGNC,2555,CUL4B,isa,FPLX,000127,CUL
+HGNC,2556,CUL5,isa,FPLX,000127,CUL
+HGNC,21024,CUL7,isa,FPLX,000127,CUL
+FPLX,000128,CXCL_ELR_negative,isa,FPLX,000099,Chemokine
+FPLX,000129,CXCL_ELR_positive,isa,FPLX,000099,Chemokine
+HGNC,10637,CXCL10,isa,FPLX,000128,CXCL_ELR_negative
+HGNC,10638,CXCL11,isa,FPLX,000128,CXCL_ELR_negative
+HGNC,10672,CXCL12,isa,FPLX,000128,CXCL_ELR_negative
+HGNC,10639,CXCL13,isa,FPLX,000128,CXCL_ELR_negative
+HGNC,10640,CXCL14,isa,FPLX,000128,CXCL_ELR_negative
+HGNC,7098,CXCL9,isa,FPLX,000128,CXCL_ELR_negative
+HGNC,8861,PF4,isa,FPLX,000128,CXCL_ELR_negative
+HGNC,4602,CXCL1,isa,FPLX,000129,CXCL_ELR_positive
+HGNC,4603,CXCL2,isa,FPLX,000129,CXCL_ELR_positive
+HGNC,4604,CXCL3,isa,FPLX,000129,CXCL_ELR_positive
+HGNC,10642,CXCL5,isa,FPLX,000129,CXCL_ELR_positive
+HGNC,10643,CXCL6,isa,FPLX,000129,CXCL_ELR_positive
+HGNC,6025,CXCL8,isa,FPLX,000129,CXCL_ELR_positive
+HGNC,9240,PPBP,isa,FPLX,000129,CXCL_ELR_positive
+HGNC,10664,CWC27,isa,FPLX,000134,Cyclophilin
+HGNC,9253,PPIA,isa,FPLX,000134,Cyclophilin
+HGNC,9255,PPIB,isa,FPLX,000134,Cyclophilin
+HGNC,9256,PPIC,isa,FPLX,000134,Cyclophilin
+HGNC,9257,PPID,isa,FPLX,000134,Cyclophilin
+HGNC,9258,PPIE,isa,FPLX,000134,Cyclophilin
+HGNC,9259,PPIF,isa,FPLX,000134,Cyclophilin
+HGNC,14651,PPIH,isa,FPLX,000134,Cyclophilin
+HGNC,9260,PPIL1,isa,FPLX,000134,Cyclophilin
+HGNC,9261,PPIL2,isa,FPLX,000134,Cyclophilin
+HGNC,9262,PPIL3,isa,FPLX,000134,Cyclophilin
+HGNC,15702,PPIL4,isa,FPLX,000134,Cyclophilin
+HGNC,21557,PPIL6,isa,FPLX,000134,Cyclophilin
+HGNC,28954,PPWD1,isa,FPLX,000134,Cyclophilin
+HGNC,24369,PPIAL4A,isa,FPLX,000134,Cyclophilin
+HGNC,33995,PPIAL4C,isa,FPLX,000134,Cyclophilin
+HGNC,33996,PPIAL4G,isa,FPLX,000134,Cyclophilin
+HGNC,2730,DDR1,isa,FPLX,000136,DDR
+HGNC,2731,DDR2,isa,FPLX,000136,DDR
+HGNC,3048,DSG1,isa,FPLX,000138,Desmoglein
+HGNC,3049,DSG2,isa,FPLX,000138,Desmoglein
+HGNC,3050,DSG3,isa,FPLX,000138,Desmoglein
+HGNC,21307,DSG4,isa,FPLX,000138,Desmoglein
+HGNC,2849,DGKA,isa,FPLX,000140,DGK
+HGNC,2850,DGKB,isa,FPLX,000140,DGK
+HGNC,2851,DGKD,isa,FPLX,000140,DGK
+HGNC,2853,DGKG,isa,FPLX,000140,DGK
+HGNC,2854,DGKH,isa,FPLX,000140,DGK
+HGNC,2856,DGKQ,isa,FPLX,000140,DGK
+HGNC,2857,DGKZ,isa,FPLX,000140,DGK
+HGNC,2852,DGKE,isa,FPLX,000140,DGK
+HGNC,2855,DGKI,isa,FPLX,000140,DGK
+HGNC,32395,DGKK,isa,FPLX,000140,DGK
+HGNC,2972,DNM1,isa,FPLX,000142,DNM
+HGNC,2974,DNM2,isa,FPLX,000142,DNM
+HGNC,29125,DNM3,isa,FPLX,000142,DNM
+HGNC,3020,DRD1,isa,FPLX,000143,DRD
+HGNC,3023,DRD2,isa,FPLX,000143,DRD
+HGNC,3024,DRD3,isa,FPLX,000143,DRD
+HGNC,3025,DRD4,isa,FPLX,000143,DRD
+HGNC,3026,DRD5,isa,FPLX,000143,DRD
+HGNC,3084,DVL1,isa,FPLX,000145,DVL
+HGNC,3086,DVL2,isa,FPLX,000145,DVL
+HGNC,3087,DVL3,isa,FPLX,000145,DVL
+HGNC,3113,E2F1,isa,FPLX,000147,E2F
+HGNC,3114,E2F2,isa,FPLX,000147,E2F
+HGNC,3115,E2F3,isa,FPLX,000147,E2F
+HGNC,3118,E2F4,isa,FPLX,000147,E2F
+HGNC,3119,E2F5,isa,FPLX,000147,E2F
+HGNC,3120,E2F6,isa,FPLX,000147,E2F
+HGNC,23820,E2F7,isa,FPLX,000147,E2F
+HGNC,24727,E2F8,isa,FPLX,000147,E2F
+HGNC,3176,EDN1,isa,FPLX,000149,EDN
+HGNC,3177,EDN2,isa,FPLX,000149,EDN
+HGNC,3178,EDN3,isa,FPLX,000149,EDN
+HGNC,651,AREG,isa,FPLX,000150,EGFR_ligand
+HGNC,3229,EGF,isa,FPLX,000150,EGFR_ligand
+HGNC,11765,TGFA,isa,FPLX,000150,EGFR_ligand
+HGNC,3059,HBEGF,isa,FPLX,000150,EGFR_ligand
+HGNC,1121,BTC,isa,FPLX,000150,EGFR_ligand
+HGNC,3443,EREG,isa,FPLX,000150,EGFR_ligand
+HGNC,17470,EPGN,isa,FPLX,000150,EGFR_ligand
+HGNC,3238,EGR1,isa,FPLX,000151,EGR
+HGNC,3239,EGR2,isa,FPLX,000151,EGR
+HGNC,3240,EGR3,isa,FPLX,000151,EGR
+HGNC,3241,EGR4,isa,FPLX,000151,EGR
+HGNC,3282,EIF4A1,isa,FPLX,000153,EIF4A
+HGNC,3284,EIF4A2,isa,FPLX,000153,EIF4A
+HGNC,18683,EIF4A3,isa,FPLX,000153,EIF4A
+HGNC,913,AZU1,isa,FPLX,000156,ELA
+HGNC,3308,CELA1,isa,FPLX,000156,ELA
+HGNC,24609,CELA2A,isa,FPLX,000156,ELA
+HGNC,29995,CELA2B,isa,FPLX,000156,ELA
+HGNC,15944,CELA3A,isa,FPLX,000156,ELA
+HGNC,15945,CELA3B,isa,FPLX,000156,ELA
+HGNC,2523,CTRC,isa,FPLX,000156,ELA
+HGNC,3309,ELANE,isa,FPLX,000156,ELA
+HGNC,9495,PRTN3,isa,FPLX,000156,ELA
+HGNC,3350,ENO1,isa,FPLX,000157,ENO
+HGNC,3353,ENO2,isa,FPLX,000157,ENO
+HGNC,3354,ENO3,isa,FPLX,000157,ENO
+HGNC,31670,ENO4,isa,FPLX,000157,ENO
+HGNC,3385,EPHA1,isa,FPLX,000158,Ephrin_receptor
+HGNC,3386,EPHA2,isa,FPLX,000158,Ephrin_receptor
+HGNC,3387,EPHA3,isa,FPLX,000158,Ephrin_receptor
+HGNC,3388,EPHA4,isa,FPLX,000158,Ephrin_receptor
+HGNC,3389,EPHA5,isa,FPLX,000158,Ephrin_receptor
+HGNC,19296,EPHA6,isa,FPLX,000158,Ephrin_receptor
+HGNC,3390,EPHA7,isa,FPLX,000158,Ephrin_receptor
+HGNC,3391,EPHA8,isa,FPLX,000158,Ephrin_receptor
+HGNC,3392,EPHB1,isa,FPLX,000158,Ephrin_receptor
+HGNC,3393,EPHB2,isa,FPLX,000158,Ephrin_receptor
+HGNC,3394,EPHB3,isa,FPLX,000158,Ephrin_receptor
+HGNC,3395,EPHB4,isa,FPLX,000158,Ephrin_receptor
+HGNC,3396,EPHB6,isa,FPLX,000158,Ephrin_receptor
+HGNC,19987,EPHA10,isa,FPLX,000158,Ephrin_receptor
+HGNC,21604,EPN1,isa,FPLX,000159,EPN
+HGNC,18639,EPN2,isa,FPLX,000159,EPN
+HGNC,18235,EPN3,isa,FPLX,000159,EPN
+HGNC,23186,CLINT1,isa,FPLX,000159,EPN
+HGNC,3467,ESR1,isa,FPLX,000162,ESR
+HGNC,3468,ESR2,isa,FPLX,000162,ESR
+HGNC,3757,FLOT1,isa,FPLX,000170,FLOT
+HGNC,3758,FLOT2,isa,FPLX,000170,FLOT
+HGNC,3760,FLRT1,isa,FPLX,000171,FLRT
+HGNC,3761,FLRT2,isa,FPLX,000171,FLRT
+HGNC,3762,FLRT3,isa,FPLX,000171,FLRT
+HGNC,4038,FZD1,isa,FPLX,000177,FZD
+HGNC,4039,FZD10,isa,FPLX,000177,FZD
+HGNC,4040,FZD2,isa,FPLX,000177,FZD
+HGNC,4041,FZD3,isa,FPLX,000177,FZD
+HGNC,4042,FZD4,isa,FPLX,000177,FZD
+HGNC,4043,FZD5,isa,FPLX,000177,FZD
+HGNC,4044,FZD6,isa,FPLX,000177,FZD
+HGNC,4045,FZD7,isa,FPLX,000177,FZD
+HGNC,4046,FZD8,isa,FPLX,000177,FZD
+HGNC,4047,FZD9,isa,FPLX,000177,FZD
+HGNC,4075,GABRA1,isa,FPLX,000179,GABR
+HGNC,4076,GABRA2,isa,FPLX,000179,GABR
+HGNC,4077,GABRA3,isa,FPLX,000179,GABR
+HGNC,4078,GABRA4,isa,FPLX,000179,GABR
+HGNC,4079,GABRA5,isa,FPLX,000179,GABR
+HGNC,4080,GABRA6,isa,FPLX,000179,GABR
+HGNC,4081,GABRB1,isa,FPLX,000179,GABR
+HGNC,4082,GABRB2,isa,FPLX,000179,GABR
+HGNC,4083,GABRB3,isa,FPLX,000179,GABR
+HGNC,4084,GABRD,isa,FPLX,000179,GABR
+HGNC,4085,GABRE,isa,FPLX,000179,GABR
+HGNC,4086,GABRG1,isa,FPLX,000179,GABR
+HGNC,4087,GABRG2,isa,FPLX,000179,GABR
+HGNC,4088,GABRG3,isa,FPLX,000179,GABR
+HGNC,4089,GABRP,isa,FPLX,000179,GABR
+HGNC,14454,GABRQ,isa,FPLX,000179,GABR
+HGNC,4090,GABRR1,isa,FPLX,000179,GABR
+HGNC,4091,GABRR2,isa,FPLX,000179,GABR
+HGNC,17969,GABRR3,isa,FPLX,000179,GABR
+HGNC,905,AXL,isa,FPLX,000183,GAS6_receptor
+HGNC,7027,MERTK,isa,FPLX,000183,GAS6_receptor
+HGNC,12446,TYRO3,isa,FPLX,000183,GAS6_receptor
+HGNC,4170,GATA1,isa,FPLX,000184,GATA
+HGNC,4171,GATA2,isa,FPLX,000184,GATA
+HGNC,4172,GATA3,isa,FPLX,000184,GATA
+HGNC,4173,GATA4,isa,FPLX,000184,GATA
+HGNC,15802,GATA5,isa,FPLX,000184,GATA
+HGNC,4174,GATA6,isa,FPLX,000184,GATA
+HGNC,4396,GNB1,isa,FPLX,000210,G_beta
+HGNC,4398,GNB2,isa,FPLX,000210,G_beta
+HGNC,4400,GNB3,isa,FPLX,000210,G_beta
+HGNC,20731,GNB4,isa,FPLX,000210,G_beta
+HGNC,4401,GNB5,isa,FPLX,000210,G_beta
+HGNC,4402,GNG10,isa,FPLX,000211,G_gamma
+HGNC,4403,GNG11,isa,FPLX,000211,G_gamma
+HGNC,19663,GNG12,isa,FPLX,000211,G_gamma
+HGNC,14131,GNG13,isa,FPLX,000211,G_gamma
+HGNC,4404,GNG2,isa,FPLX,000211,G_gamma
+HGNC,4405,GNG3,isa,FPLX,000211,G_gamma
+HGNC,4407,GNG4,isa,FPLX,000211,G_gamma
+HGNC,4408,GNG5,isa,FPLX,000211,G_gamma
+HGNC,4410,GNG7,isa,FPLX,000211,G_gamma
+HGNC,19664,GNG8,isa,FPLX,000211,G_gamma
+HGNC,4411,GNGT1,isa,FPLX,000211,G_gamma
+HGNC,4412,GNGT2,isa,FPLX,000211,G_gamma
+HGNC,4553,GPX1,isa,FPLX,000190,GPX
+HGNC,4554,GPX2,isa,FPLX,000190,GPX
+HGNC,4555,GPX3,isa,FPLX,000190,GPX
+HGNC,4556,GPX4,isa,FPLX,000190,GPX
+HGNC,4557,GPX5,isa,FPLX,000190,GPX
+HGNC,4558,GPX6,isa,FPLX,000190,GPX
+HGNC,4559,GPX7,isa,FPLX,000190,GPX
+HGNC,33100,GPX8,isa,FPLX,000190,GPX
+HGNC,4571,GRIA1,isa,FPLX,000191,GRIA
+HGNC,4572,GRIA2,isa,FPLX,000191,GRIA
+HGNC,4573,GRIA3,isa,FPLX,000191,GRIA
+HGNC,4574,GRIA4,isa,FPLX,000191,GRIA
+FPLX,000022,ADRBK,isa,FPLX,000192,GRK
+HGNC,10013,GRK1,isa,FPLX,000192,GRK
+HGNC,4543,GRK4,isa,FPLX,000192,GRK
+HGNC,4544,GRK5,isa,FPLX,000192,GRK
+HGNC,4545,GRK6,isa,FPLX,000192,GRK
+HGNC,17031,GRK7,isa,FPLX,000192,GRK
+HGNC,4593,GRM1,isa,FPLX,000193,GRM
+HGNC,4594,GRM2,isa,FPLX,000193,GRM
+HGNC,4595,GRM3,isa,FPLX,000193,GRM
+HGNC,4596,GRM4,isa,FPLX,000193,GRM
+HGNC,4597,GRM5,isa,FPLX,000193,GRM
+HGNC,4598,GRM6,isa,FPLX,000193,GRM
+HGNC,4599,GRM7,isa,FPLX,000193,GRM
+HGNC,4600,GRM8,isa,FPLX,000193,GRM
+HGNC,4626,GSTA1,isa,FPLX,000195,GST
+HGNC,4627,GSTA2,isa,FPLX,000195,GST
+HGNC,4628,GSTA3,isa,FPLX,000195,GST
+HGNC,4629,GSTA4,isa,FPLX,000195,GST
+HGNC,19662,GSTA5,isa,FPLX,000195,GST
+HGNC,16906,GSTK1,isa,FPLX,000195,GST
+HGNC,4632,GSTM1,isa,FPLX,000195,GST
+HGNC,4634,GSTM2,isa,FPLX,000195,GST
+HGNC,4635,GSTM3,isa,FPLX,000195,GST
+HGNC,4636,GSTM4,isa,FPLX,000195,GST
+HGNC,4637,GSTM5,isa,FPLX,000195,GST
+HGNC,13312,GSTO1,isa,FPLX,000195,GST
+HGNC,23064,GSTO2,isa,FPLX,000195,GST
+HGNC,4638,GSTP1,isa,FPLX,000195,GST
+HGNC,4641,GSTT1,isa,FPLX,000195,GST
+HGNC,4642,GSTT2,isa,FPLX,000195,GST
+HGNC,4643,GSTZ1,isa,FPLX,000195,GST
+HGNC,33437,GSTT2B,isa,FPLX,000195,GST
+HGNC,4688,GUCY2C,isa,FPLX,000205,GUCY
+HGNC,4689,GUCY2D,isa,FPLX,000205,GUCY
+HGNC,4691,GUCY2F,isa,FPLX,000205,GUCY
+HGNC,7943,NPR1,isa,FPLX,000205,GUCY
+HGNC,7944,NPR2,isa,FPLX,000205,GUCY
+HGNC,2865,DHH,isa,FPLX,000226,Hedgehog
+HGNC,5956,IHH,isa,FPLX,000226,Hedgehog
+HGNC,10848,SHH,isa,FPLX,000226,Hedgehog
+HGNC,5192,HES1,isa,FPLX,000228,HES
+HGNC,16005,HES2,isa,FPLX,000228,HES
+HGNC,26226,HES3,isa,FPLX,000228,HES
+HGNC,24149,HES4,isa,FPLX,000228,HES
+HGNC,19764,HES5,isa,FPLX,000228,HES
+HGNC,18254,HES6,isa,FPLX,000228,HES
+HGNC,15977,HES7,isa,FPLX,000228,HES
+HGNC,4947,HLA-DRA,isa,FPLX,000239,HLA_DR
+HGNC,4948,HLA-DRB1,isa,FPLX,000239,HLA_DR
+HGNC,4951,HLA-DRB3,isa,FPLX,000239,HLA_DR
+HGNC,4952,HLA-DRB4,isa,FPLX,000239,HLA_DR
+HGNC,4953,HLA-DRB5,isa,FPLX,000239,HLA_DR
+HGNC,5013,HMOX1,isa,FPLX,000240,HMOX
+HGNC,5014,HMOX2,isa,FPLX,000240,HMOX
+HGNC,19022,HSPA12A,isa,FPLX,000244,HSPA
+HGNC,16193,HSPA12B,isa,FPLX,000244,HSPA
+HGNC,11375,HSPA13,isa,FPLX,000244,HSPA
+HGNC,29526,HSPA14,isa,FPLX,000244,HSPA
+HGNC,5232,HSPA1A,isa,FPLX,000244,HSPA
+HGNC,5233,HSPA1B,isa,FPLX,000244,HSPA
+HGNC,5234,HSPA1L,isa,FPLX,000244,HSPA
+HGNC,5235,HSPA2,isa,FPLX,000244,HSPA
+HGNC,5237,HSPA4,isa,FPLX,000244,HSPA
+HGNC,17041,HSPA4L,isa,FPLX,000244,HSPA
+HGNC,5238,HSPA5,isa,FPLX,000244,HSPA
+HGNC,5239,HSPA6,isa,FPLX,000244,HSPA
+HGNC,5241,HSPA8,isa,FPLX,000244,HSPA
+HGNC,5244,HSPA9,isa,FPLX,000244,HSPA
+HGNC,16969,HSPH1,isa,FPLX,000244,HSPA
+HGNC,16931,HYOU1,isa,FPLX,000244,HSPA
+HGNC,5246,HSPB1,isa,FPLX,000245,HSPB
+HGNC,5247,HSPB2,isa,FPLX,000245,HSPB
+HGNC,30171,HSPB8,isa,FPLX,000245,HSPB
+HGNC,5469,IGFBP1,isa,FPLX,000248,IGFBP
+HGNC,5471,IGFBP2,isa,FPLX,000248,IGFBP
+HGNC,5472,IGFBP3,isa,FPLX,000248,IGFBP
+HGNC,5473,IGFBP4,isa,FPLX,000248,IGFBP
+HGNC,5474,IGFBP5,isa,FPLX,000248,IGFBP
+HGNC,5475,IGFBP6,isa,FPLX,000248,IGFBP
+HGNC,5476,IGFBP7,isa,FPLX,000248,IGFBP
+HGNC,1974,CHUK,isa,FPLX,000251,IKK_family
+HGNC,5960,IKBKB,isa,FPLX,000251,IKK_family
+HGNC,5961,IKBKG,isa,FPLX,000251,IKK_family
+HGNC,14552,IKBKE,isa,FPLX,000251,IKK_family
+HGNC,11584,TBK1,isa,FPLX,000251,IKK_family
+HGNC,5465,IGF1R,isa,FPLX,000260,INSR
+HGNC,6081,INS,isa,FPLX,000259,INS
+HGNC,6091,INSR,isa,FPLX,000260,INSR
+HGNC,6093,INSRR,isa,FPLX,000260,INSR
+HGNC,6125,IRS1,isa,FPLX,000264,IRS
+HGNC,6126,IRS2,isa,FPLX,000264,IRS
+HGNC,6128,IRS4,isa,FPLX,000264,IRS
+HGNC,14358,IRX1,isa,FPLX,000265,IRX
+HGNC,14359,IRX2,isa,FPLX,000265,IRX
+HGNC,14360,IRX3,isa,FPLX,000265,IRX
+HGNC,6129,IRX4,isa,FPLX,000265,IRX
+HGNC,14361,IRX5,isa,FPLX,000265,IRX
+HGNC,14675,IRX6,isa,FPLX,000265,IRX
+HGNC,23729,MKX,isa,FPLX,000265,IRX
+HGNC,6357,KLK1,isa,FPLX,000271,KLK
+HGNC,6358,KLK10,isa,FPLX,000271,KLK
+HGNC,6359,KLK11,isa,FPLX,000271,KLK
+HGNC,6360,KLK12,isa,FPLX,000271,KLK
+HGNC,6361,KLK13,isa,FPLX,000271,KLK
+HGNC,6362,KLK14,isa,FPLX,000271,KLK
+HGNC,20453,KLK15,isa,FPLX,000271,KLK
+HGNC,6363,KLK2,isa,FPLX,000271,KLK
+HGNC,6364,KLK3,isa,FPLX,000271,KLK
+HGNC,6365,KLK4,isa,FPLX,000271,KLK
+HGNC,6366,KLK5,isa,FPLX,000271,KLK
+HGNC,6367,KLK6,isa,FPLX,000271,KLK
+HGNC,6368,KLK7,isa,FPLX,000271,KLK
+HGNC,6369,KLK8,isa,FPLX,000271,KLK
+HGNC,6370,KLK9,isa,FPLX,000271,KLK
+HGNC,6371,KLKB1,isa,FPLX,000271,KLK
+HGNC,6776,MAF,isa,FPLX,000279,MAF
+HGNC,23145,MAFA,isa,FPLX,000279,MAF
+HGNC,6408,MAFB,isa,FPLX,000279,MAF
+HGNC,6780,MAFF,isa,FPLX,000279,MAF
+HGNC,6781,MAFG,isa,FPLX,000279,MAF
+HGNC,6782,MAFK,isa,FPLX,000279,MAF
+HGNC,6881,MAPK8,isa,FPLX,000267,JNK
+HGNC,6886,MAPK9,isa,FPLX,000267,JNK
+HGNC,6872,MAPK10,isa,FPLX,000267,JNK
+FPLX,000267,JNK,isa,FPLX,000283,MAPK
+HGNC,6993,MEF2A,isa,FPLX,000285,MEF2
+HGNC,6996,MEF2C,isa,FPLX,000285,MEF2
+HGNC,6997,MEF2D,isa,FPLX,000285,MEF2
+HGNC,6995,MEF2B,isa,FPLX,000285,MEF2
+HGNC,7567,MYH1,isa,FPLX,000295,MYH
+HGNC,7568,MYH10,isa,FPLX,000295,MYH
+HGNC,7569,MYH11,isa,FPLX,000295,MYH
+HGNC,7571,MYH13,isa,FPLX,000295,MYH
+HGNC,23212,MYH14,isa,FPLX,000295,MYH
+HGNC,31073,MYH15,isa,FPLX,000295,MYH
+HGNC,7572,MYH2,isa,FPLX,000295,MYH
+HGNC,7573,MYH3,isa,FPLX,000295,MYH
+HGNC,7574,MYH4,isa,FPLX,000295,MYH
+HGNC,7576,MYH6,isa,FPLX,000295,MYH
+HGNC,7577,MYH7,isa,FPLX,000295,MYH
+HGNC,15906,MYH7B,isa,FPLX,000295,MYH
+HGNC,7578,MYH8,isa,FPLX,000295,MYH
+HGNC,7579,MYH9,isa,FPLX,000295,MYH
+HGNC,7602,MYO5A,isa,FPLX,000295,MYH
+HGNC,7582,MYL1,isa,FPLX,000297,MYL_alkali
+HGNC,7584,MYL3,isa,FPLX,000297,MYL_alkali
+HGNC,7585,MYL4,isa,FPLX,000297,MYL_alkali
+HGNC,7587,MYL6,isa,FPLX,000297,MYL_alkali
+HGNC,29823,MYL6B,isa,FPLX,000297,MYL_alkali
+HGNC,29825,MYL10,isa,FPLX,000298,MYL_regulatory
+HGNC,16701,MYL12A,isa,FPLX,000298,MYL_regulatory
+HGNC,29827,MYL12B,isa,FPLX,000298,MYL_regulatory
+HGNC,7583,MYL2,isa,FPLX,000298,MYL_regulatory
+HGNC,7586,MYL5,isa,FPLX,000298,MYL_regulatory
+HGNC,21719,MYL7,isa,FPLX,000298,MYL_regulatory
+HGNC,15754,MYL9,isa,FPLX,000298,MYL_regulatory
+HGNC,29824,MYLPF,isa,FPLX,000298,MYL_regulatory
+HGNC,7583,MYL2,isa,FPLX,000299,MYL_slow
+HGNC,7584,MYL3,isa,FPLX,000299,MYL_slow
+HGNC,29823,MYL6B,isa,FPLX,000299,MYL_slow
+FPLX,000297,MYL_alkali,isa,FPLX,000296,MYL
+FPLX,000298,MYL_regulatory,isa,FPLX,000296,MYL
+FPLX,000299,MYL_slow,isa,FPLX,000296,MYL
+HGNC,17933,KAT8,isa,FPLX,000300,MYST
+HGNC,17016,KAT7,isa,FPLX,000300,MYST
+HGNC,13013,KAT6A,isa,FPLX,000300,MYST
+HGNC,17582,KAT6B,isa,FPLX,000300,MYST
+HGNC,5275,KAT5,isa,FPLX,000300,MYST
+HGNC,7668,NCOA1,isa,FPLX,000305,NCOA
+HGNC,7669,NCOA2,isa,FPLX,000305,NCOA
+HGNC,7670,NCOA3,isa,FPLX,000305,NCOA
+HGNC,7672,NCOR1,isa,FPLX,000306,NCOR
+HGNC,7673,NCOR2,isa,FPLX,000306,NCOR
+HGNC,7679,NDRG1,isa,FPLX,000307,NDRG
+HGNC,14460,NDRG2,isa,FPLX,000307,NDRG
+HGNC,14462,NDRG3,isa,FPLX,000307,NDRG
+HGNC,14466,NDRG4,isa,FPLX,000307,NDRG
+HGNC,17045,NKD1,isa,FPLX,000315,NKD
+HGNC,17046,NKD2,isa,FPLX,000315,NKD
+HGNC,7872,NOS1,isa,FPLX,000316,NOS
+HGNC,7873,NOS2,isa,FPLX,000316,NOS
+HGNC,7876,NOS3,isa,FPLX,000316,NOS
+HGNC,7881,NOTCH1,isa,FPLX,000317,Notch
+HGNC,7882,NOTCH2,isa,FPLX,000317,Notch
+HGNC,7883,NOTCH3,isa,FPLX,000317,Notch
+HGNC,7884,NOTCH4,isa,FPLX,000317,Notch
+HGNC,7997,NRG1,isa,FPLX,000319,NRG_1_2
+HGNC,7998,NRG2,isa,FPLX,000319,NRG_1_2
+HGNC,7999,NRG3,isa,FPLX,000320,NRG_3_4
+HGNC,29862,NRG4,isa,FPLX,000320,NRG_3_4
+FPLX,000319,NRG_1_2,isa,FPLX,000318,NRG
+FPLX,000320,NRG_3_4,isa,FPLX,000318,NRG
+HGNC,8031,NTRK1,isa,FPLX,000321,NTRK
+HGNC,8032,NTRK2,isa,FPLX,000321,NTRK
+HGNC,8033,NTRK3,isa,FPLX,000321,NTRK
+HGNC,8533,P2RX1,isa,FPLX,000324,P2RX
+HGNC,15459,P2RX2,isa,FPLX,000324,P2RX
+HGNC,8534,P2RX3,isa,FPLX,000324,P2RX
+HGNC,8535,P2RX4,isa,FPLX,000324,P2RX
+HGNC,8536,P2RX5,isa,FPLX,000324,P2RX
+HGNC,8538,P2RX6,isa,FPLX,000324,P2RX
+HGNC,8537,P2RX7,isa,FPLX,000324,P2RX
+HGNC,8539,P2RY1,isa,FPLX,000325,P2RY
+HGNC,8541,P2RY2,isa,FPLX,000325,P2RY
+HGNC,8542,P2RY4,isa,FPLX,000325,P2RY
+HGNC,8543,P2RY6,isa,FPLX,000325,P2RY
+HGNC,15524,P2RY8,isa,FPLX,000325,P2RY
+HGNC,19906,P2RY10,isa,FPLX,000325,P2RY
+HGNC,8540,P2RY11,isa,FPLX,000325,P2RY
+HGNC,18124,P2RY12,isa,FPLX,000325,P2RY
+HGNC,4537,P2RY13,isa,FPLX,000325,P2RY
+HGNC,16442,P2RY14,isa,FPLX,000325,P2RY
+HGNC,4478,LPAR4,isa,FPLX,000325,P2RY
+HGNC,15520,LPAR6,isa,FPLX,000325,P2RY
+HGNC,14652,PARVA,isa,FPLX,000332,PARV
+HGNC,14653,PARVB,isa,FPLX,000332,PARV
+HGNC,14654,PARVG,isa,FPLX,000332,PARV
+HGNC,8632,PBX1,isa,FPLX,000334,PBX
+HGNC,8633,PBX2,isa,FPLX,000334,PBX
+HGNC,8634,PBX3,isa,FPLX,000334,PBX
+HGNC,13403,PBX4,isa,FPLX,000334,PBX
+HGNC,8774,PDE1A,isa,FPLX,000336,PDE1
+HGNC,8775,PDE1B,isa,FPLX,000336,PDE1
+HGNC,8776,PDE1C,isa,FPLX,000336,PDE1
+HGNC,8777,PDE2A,isa,FPLX,000335,PDE
+HGNC,8778,PDE3A,isa,FPLX,000337,PDE3
+HGNC,8779,PDE3B,isa,FPLX,000337,PDE3
+HGNC,8780,PDE4A,isa,FPLX,000338,PDE4
+HGNC,8781,PDE4B,isa,FPLX,000338,PDE4
+HGNC,8782,PDE4C,isa,FPLX,000338,PDE4
+HGNC,8783,PDE4D,isa,FPLX,000338,PDE4
+HGNC,8785,PDE6A,isa,FPLX,000339,PDE6
+HGNC,8786,PDE6B,isa,FPLX,000339,PDE6
+HGNC,8787,PDE6C,isa,FPLX,000339,PDE6
+HGNC,8791,PDE7A,isa,FPLX,000340,PDE7
+HGNC,8792,PDE7B,isa,FPLX,000340,PDE7
+HGNC,8793,PDE8A,isa,FPLX,000341,PDE8
+HGNC,8794,PDE8B,isa,FPLX,000341,PDE8
+HGNC,8795,PDE9A,isa,FPLX,000335,PDE
+HGNC,8772,PDE10A,isa,FPLX,000335,PDE
+HGNC,8773,PDE11A,isa,FPLX,000335,PDE
+FPLX,000336,PDE1,isa,FPLX,000335,PDE
+FPLX,000337,PDE3,isa,FPLX,000335,PDE
+FPLX,000338,PDE4,isa,FPLX,000335,PDE
+FPLX,000339,PDE6,isa,FPLX,000335,PDE
+FPLX,000340,PDE7,isa,FPLX,000335,PDE
+FPLX,000341,PDE8,isa,FPLX,000335,PDE
+HGNC,8809,PDK1,isa,FPLX,000353,PDK
+HGNC,8810,PDK2,isa,FPLX,000353,PDK
+HGNC,8811,PDK3,isa,FPLX,000353,PDK
+HGNC,8812,PDK4,isa,FPLX,000353,PDK
+HGNC,8881,PFN1,isa,FPLX,000355,PFN
+HGNC,8882,PFN2,isa,FPLX,000355,PFN
+HGNC,18627,PFN3,isa,FPLX,000355,PFN
+HGNC,31103,PFN4,isa,FPLX,000355,PFN
+HGNC,8975,PIK3CA,isa,FPLX,000359,PI3K_p110
+HGNC,8976,PIK3CB,isa,FPLX,000359,PI3K_p110
+HGNC,8977,PIK3CD,isa,FPLX,000359,PI3K_p110
+HGNC,8978,PIK3CG,isa,FPLX,000359,PI3K_p110
+HGNC,8979,PIK3R1,isa,FPLX,000360,PI3K_p85
+HGNC,8980,PIK3R2,isa,FPLX,000360,PI3K_p85
+HGNC,8981,PIK3R3,isa,FPLX,000361,PIK3R_I
+HGNC,8982,PIK3R4,isa,FPLX,000361,PIK3R_I
+HGNC,30035,PIK3R5,isa,FPLX,000361,PIK3R_I
+HGNC,27101,PIK3R6,isa,FPLX,000361,PIK3R_I
+FPLX,000360,PI3K_p85,isa,FPLX,000361,PIK3R_I
+FPLX,000359,PI3K_p110,partof,FPLX,000358,PI3K
+FPLX,000361,PIK3R_I,partof,FPLX,000358,PI3K
+HGNC,9017,PKIA,isa,FPLX,000365,PKI
+HGNC,9018,PKIB,isa,FPLX,000365,PKI
+HGNC,9019,PKIG,isa,FPLX,000365,PKI
+HGNC,9030,PLA2G1B,isa,FPLX,000366,PLA2
+HGNC,9031,PLA2G2A,isa,FPLX,000367,PLA2G2
+HGNC,9032,PLA2G2C,isa,FPLX,000367,PLA2G2
+HGNC,9033,PLA2G2D,isa,FPLX,000367,PLA2G2
+HGNC,13414,PLA2G2E,isa,FPLX,000367,PLA2G2
+HGNC,30040,PLA2G2F,isa,FPLX,000367,PLA2G2
+HGNC,17934,PLA2G3,isa,FPLX,000366,PLA2
+HGNC,9035,PLA2G4A,isa,FPLX,000368,PLA2G4
+HGNC,9037,PLA2G4C,isa,FPLX,000368,PLA2G4
+HGNC,30038,PLA2G4D,isa,FPLX,000368,PLA2G4
+HGNC,9038,PLA2G5,isa,FPLX,000366,PLA2
+HGNC,9039,PLA2G6,isa,FPLX,000366,PLA2
+HGNC,9040,PLA2G7,isa,FPLX,000366,PLA2
+HGNC,9029,PLA2G10,isa,FPLX,000366,PLA2
+HGNC,18554,PLA2G12A,isa,FPLX,000366,PLA2
+HGNC,18555,PLA2G12B,isa,FPLX,000366,PLA2
+FPLX,000367,PLA2G2,isa,FPLX,000366,PLA2
+FPLX,000368,PLA2G4,isa,FPLX,000366,PLA2
+HGNC,15917,PLCB1,isa,FPLX,000370,PLCB
+HGNC,9055,PLCB2,isa,FPLX,000370,PLCB
+HGNC,9056,PLCB3,isa,FPLX,000370,PLCB
+HGNC,9059,PLCB4,isa,FPLX,000370,PLCB
+HGNC,9060,PLCD1,isa,FPLX,000371,PLCD
+HGNC,9061,PLCD3,isa,FPLX,000371,PLCD
+HGNC,9062,PLCD4,isa,FPLX,000371,PLCD
+HGNC,17175,PLCE1,isa,FPLX,000369,PLC
+HGNC,9065,PLCG1,isa,FPLX,000372,PLCG
+HGNC,9066,PLCG2,isa,FPLX,000372,PLCG
+HGNC,19218,PLCZ1,isa,FPLX,000369,PLC
+FPLX,000370,PLCB,isa,FPLX,000369,PLC
+FPLX,000371,PLCD,isa,FPLX,000369,PLC
+FPLX,000372,PLCG,isa,FPLX,000369,PLC
+HGNC,9067,PLD1,isa,FPLX,000373,PLD
+HGNC,9068,PLD2,isa,FPLX,000373,PLD
+HGNC,17158,PLD3,isa,FPLX,000373,PLD
+HGNC,23792,PLD4,isa,FPLX,000373,PLD
+HGNC,26879,PLD5,isa,FPLX,000373,PLD
+HGNC,30447,PLD6,isa,FPLX,000373,PLD
+HGNC,9228,PLPP1,isa,FPLX,000374,PPAP2
+HGNC,9230,PLPP2,isa,FPLX,000374,PPAP2
+HGNC,9229,PLPP3,isa,FPLX,000374,PPAP2
+HGNC,9232,PPARA,isa,FPLX,000375,PPAR
+HGNC,9235,PPARD,isa,FPLX,000375,PPAR
+HGNC,9236,PPARG,isa,FPLX,000375,PPAR
+HGNC,9281,PPP1CA,isa,FPLX,000377,PPP1C
+HGNC,9282,PPP1CB,isa,FPLX,000377,PPP1C
+HGNC,9283,PPP1CC,isa,FPLX,000377,PPP1C
+HGNC,9284,PPP1R10,isa,FPLX,000378,PPP1R
+HGNC,9285,PPP1R11,isa,FPLX,000378,PPP1R
+HGNC,7618,PPP1R12A,isa,FPLX,000378,PPP1R
+HGNC,7619,PPP1R12B,isa,FPLX,000378,PPP1R
+HGNC,14947,PPP1R12C,isa,FPLX,000378,PPP1R
+HGNC,14950,PPP1R13B,isa,FPLX,000378,PPP1R
+HGNC,14871,PPP1R14A,isa,FPLX,000378,PPP1R
+HGNC,9057,PPP1R14B,isa,FPLX,000378,PPP1R
+HGNC,14952,PPP1R14C,isa,FPLX,000378,PPP1R
+HGNC,14953,PPP1R14D,isa,FPLX,000378,PPP1R
+HGNC,14375,PPP1R15A,isa,FPLX,000378,PPP1R
+HGNC,14951,PPP1R15B,isa,FPLX,000378,PPP1R
+HGNC,14941,PPP1R16A,isa,FPLX,000378,PPP1R
+HGNC,15850,PPP1R16B,isa,FPLX,000378,PPP1R
+HGNC,9286,PPP1R1A,isa,FPLX,000378,PPP1R
+HGNC,9287,PPP1R1B,isa,FPLX,000378,PPP1R
+HGNC,14940,PPP1R1C,isa,FPLX,000378,PPP1R
+HGNC,9288,PPP1R2,isa,FPLX,000378,PPP1R
+HGNC,9291,PPP1R3A,isa,FPLX,000378,PPP1R
+HGNC,14942,PPP1R3B,isa,FPLX,000378,PPP1R
+HGNC,9293,PPP1R3C,isa,FPLX,000378,PPP1R
+HGNC,9294,PPP1R3D,isa,FPLX,000378,PPP1R
+HGNC,14944,PPP1R3F,isa,FPLX,000378,PPP1R
+HGNC,9295,PPP1R7,isa,FPLX,000378,PPP1R
+HGNC,9296,PPP1R8,isa,FPLX,000378,PPP1R
+HGNC,14946,PPP1R9A,isa,FPLX,000378,PPP1R
+HGNC,9298,PPP1R9B,isa,FPLX,000378,PPP1R
+FPLX,000377,PPP1C,partof,FPLX,000376,PPP1
+FPLX,000378,PPP1R,partof,FPLX,000376,PPP1
+HGNC,20785,PPM1J,isa,FPLX,000380,PPP2C
+HGNC,9299,PPP2CA,isa,FPLX,000380,PPP2C
+HGNC,9300,PPP2CB,isa,FPLX,000380,PPP2C
+HGNC,9302,PPP2R1A,isa,FPLX,000381,PPP2R_A
+HGNC,9303,PPP2R1B,isa,FPLX,000381,PPP2R_A
+HGNC,9304,PPP2R2A,isa,FPLX,000382,PPP2R_B
+HGNC,9305,PPP2R2B,isa,FPLX,000382,PPP2R_B
+HGNC,9306,PPP2R2C,isa,FPLX,000382,PPP2R_B
+HGNC,23732,PPP2R2D,isa,FPLX,000382,PPP2R_B
+HGNC,9307,PPP2R3A,isa,FPLX,000382,PPP2R_B
+HGNC,13417,PPP2R3B,isa,FPLX,000382,PPP2R_B
+HGNC,9308,PTPA,isa,FPLX,000382,PPP2R_B
+HGNC,9309,PPP2R5A,isa,FPLX,000382,PPP2R_B
+HGNC,9310,PPP2R5B,isa,FPLX,000382,PPP2R_B
+HGNC,9311,PPP2R5C,isa,FPLX,000382,PPP2R_B
+HGNC,9312,PPP2R5D,isa,FPLX,000382,PPP2R_B
+HGNC,9313,PPP2R5E,isa,FPLX,000382,PPP2R_B
+FPLX,000380,PPP2C,partof,FPLX,000379,PPP2
+FPLX,000381,PPP2R_A,partof,FPLX,000379,PPP2
+FPLX,000382,PPP2R_B,partof,FPLX,000379,PPP2
+HGNC,9314,PPP3CA,isa,FPLX,000384,PPP3C
+HGNC,9315,PPP3CB,isa,FPLX,000384,PPP3C
+HGNC,9316,PPP3CC,isa,FPLX,000384,PPP3C
+HGNC,9317,PPP3R1,isa,FPLX,000385,PPP3R
+HGNC,9318,PPP3R2,isa,FPLX,000385,PPP3R
+FPLX,000384,PPP3C,partof,FPLX,000383,PPP3
+FPLX,000385,PPP3R,partof,FPLX,000383,PPP3
+HGNC,9352,PRDX1,isa,FPLX,000388,PRDX
+HGNC,9353,PRDX2,isa,FPLX,000388,PRDX
+HGNC,9354,PRDX3,isa,FPLX,000388,PRDX
+HGNC,17169,PRDX4,isa,FPLX,000388,PRDX
+HGNC,9355,PRDX5,isa,FPLX,000388,PRDX
+HGNC,16753,PRDX6,isa,FPLX,000388,PRDX
+HGNC,9388,PRKAR1A,isa,FPLX,000390,PRKAR
+HGNC,9390,PRKAR1B,isa,FPLX,000390,PRKAR
+HGNC,9391,PRKAR2A,isa,FPLX,000390,PRKAR
+HGNC,9392,PRKAR2B,isa,FPLX,000390,PRKAR
+HGNC,9380,PRKACA,isa,FPLX,000389,PRKAC
+HGNC,9381,PRKACB,isa,FPLX,000389,PRKAC
+HGNC,9382,PRKACG,isa,FPLX,000389,PRKAC
+FPLX,000390,PRKAR,partof,FPLX,000363,PKA
+FPLX,000389,PRKAC,partof,FPLX,000363,PKA
+HGNC,9393,PRKCA,isa,FPLX,000364,PKC
+HGNC,9395,PRKCB,isa,FPLX,000364,PKC
+HGNC,9399,PRKCD,isa,FPLX,000364,PKC
+HGNC,9401,PRKCE,isa,FPLX,000364,PKC
+HGNC,9402,PRKCG,isa,FPLX,000364,PKC
+HGNC,9403,PRKCH,isa,FPLX,000364,PKC
+HGNC,9404,PRKCI,isa,FPLX,000364,PKC
+HGNC,9410,PRKCQ,isa,FPLX,000364,PKC
+HGNC,9412,PRKCZ,isa,FPLX,000364,PKC
+HGNC,9408,PRKD3,isa,FPLX,000364,PKC
+HGNC,9414,PRKG1,isa,FPLX,000391,PRKG
+HGNC,9416,PRKG2,isa,FPLX,000391,PRKG
+HGNC,9593,PTGER1,isa,FPLX,000395,PTGER
+HGNC,9594,PTGER2,isa,FPLX,000395,PTGER
+HGNC,9595,PTGER3,isa,FPLX,000395,PTGER
+HGNC,9596,PTGER4,isa,FPLX,000395,PTGER
+HGNC,9759,RAB10,isa,FPLX,000397,RAB
+HGNC,9760,RAB11A,isa,FPLX,000397,RAB
+HGNC,9761,RAB11B,isa,FPLX,000397,RAB
+HGNC,31332,RAB12,isa,FPLX,000397,RAB
+HGNC,9762,RAB13,isa,FPLX,000397,RAB
+HGNC,16524,RAB14,isa,FPLX,000397,RAB
+HGNC,20150,RAB15,isa,FPLX,000397,RAB
+HGNC,16523,RAB17,isa,FPLX,000397,RAB
+HGNC,14244,RAB18,isa,FPLX,000397,RAB
+HGNC,19982,RAB19,isa,FPLX,000397,RAB
+HGNC,9758,RAB1A,isa,FPLX,000397,RAB
+HGNC,18370,RAB1B,isa,FPLX,000397,RAB
+HGNC,23683,RAB1C,isa,FPLX,000397,RAB
+HGNC,18260,RAB20,isa,FPLX,000397,RAB
+HGNC,18263,RAB21,isa,FPLX,000397,RAB
+HGNC,9764,RAB22A,isa,FPLX,000397,RAB
+HGNC,14263,RAB23,isa,FPLX,000397,RAB
+HGNC,9765,RAB24,isa,FPLX,000397,RAB
+HGNC,18238,RAB25,isa,FPLX,000397,RAB
+HGNC,14259,RAB26,isa,FPLX,000397,RAB
+HGNC,9766,RAB27A,isa,FPLX,000397,RAB
+HGNC,9767,RAB27B,isa,FPLX,000397,RAB
+HGNC,9768,RAB28,isa,FPLX,000397,RAB
+HGNC,9763,RAB2A,isa,FPLX,000397,RAB
+HGNC,20246,RAB2B,isa,FPLX,000397,RAB
+HGNC,9770,RAB30,isa,FPLX,000397,RAB
+HGNC,9771,RAB31,isa,FPLX,000397,RAB
+HGNC,9772,RAB32,isa,FPLX,000397,RAB
+HGNC,9773,RAB33A,isa,FPLX,000397,RAB
+HGNC,16075,RAB33B,isa,FPLX,000397,RAB
+HGNC,16519,RAB34,isa,FPLX,000397,RAB
+HGNC,9774,RAB35,isa,FPLX,000397,RAB
+HGNC,9775,RAB36,isa,FPLX,000397,RAB
+HGNC,30268,RAB37,isa,FPLX,000397,RAB
+HGNC,9776,RAB38,isa,FPLX,000397,RAB
+HGNC,16521,RAB39A,isa,FPLX,000397,RAB
+HGNC,16499,RAB39B,isa,FPLX,000397,RAB
+HGNC,9777,RAB3A,isa,FPLX,000397,RAB
+HGNC,9778,RAB3B,isa,FPLX,000397,RAB
+HGNC,30269,RAB3C,isa,FPLX,000397,RAB
+HGNC,9779,RAB3D,isa,FPLX,000397,RAB
+HGNC,18283,RAB40A,isa,FPLX,000397,RAB
+HGNC,25410,RAB40AL,isa,FPLX,000397,RAB
+HGNC,18284,RAB40B,isa,FPLX,000397,RAB
+HGNC,18285,RAB40C,isa,FPLX,000397,RAB
+HGNC,18293,RAB41,isa,FPLX,000397,RAB
+HGNC,28702,RAB42,isa,FPLX,000397,RAB
+HGNC,19983,RAB43,isa,FPLX,000397,RAB
+HGNC,21068,RAB44,isa,FPLX,000397,RAB
+HGNC,9781,RAB4A,isa,FPLX,000397,RAB
+HGNC,9782,RAB4B,isa,FPLX,000397,RAB
+HGNC,9783,RAB5A,isa,FPLX,000397,RAB
+HGNC,9784,RAB5B,isa,FPLX,000397,RAB
+HGNC,9785,RAB5C,isa,FPLX,000397,RAB
+HGNC,9786,RAB6A,isa,FPLX,000397,RAB
+HGNC,14902,RAB6B,isa,FPLX,000397,RAB
+HGNC,16525,RAB6C,isa,FPLX,000397,RAB
+HGNC,9788,RAB7A,isa,FPLX,000397,RAB
+HGNC,30513,RAB7B,isa,FPLX,000397,RAB
+HGNC,9789,RAB29,isa,FPLX,000397,RAB
+HGNC,7007,RAB8A,isa,FPLX,000397,RAB
+HGNC,30273,RAB8B,isa,FPLX,000397,RAB
+HGNC,9792,RAB9A,isa,FPLX,000397,RAB
+HGNC,14090,RAB9B,isa,FPLX,000397,RAB
+HGNC,9799,RABL2A,isa,FPLX,000397,RAB
+HGNC,9800,RABL2B,isa,FPLX,000397,RAB
+HGNC,18072,RABL3,isa,FPLX,000397,RAB
+HGNC,21895,IFT22,isa,FPLX,000397,RAB
+HGNC,9864,RARA,isa,FPLX,000403,RAR
+HGNC,9865,RARB,isa,FPLX,000403,RAR
+HGNC,9866,RARG,isa,FPLX,000403,RAR
+HGNC,9982,RFX1,isa,FPLX,000412,RFX
+HGNC,9983,RFX2,isa,FPLX,000412,RFX
+HGNC,9984,RFX3,isa,FPLX,000412,RFX
+HGNC,9985,RFX4,isa,FPLX,000412,RFX
+HGNC,9986,RFX5,isa,FPLX,000412,RFX
+HGNC,21478,RFX6,isa,FPLX,000412,RFX
+HGNC,25777,RFX7,isa,FPLX,000412,RFX
+HGNC,37253,RFX8,isa,FPLX,000412,RFX
+HGNC,10256,ROR1,isa,FPLX,000420,ROR
+HGNC,10257,ROR2,isa,FPLX,000420,ROR
+HGNC,10477,RXRA,isa,FPLX,000424,RXR
+HGNC,10478,RXRB,isa,FPLX,000424,RXR
+HGNC,10479,RXRG,isa,FPLX,000424,RXR
+HGNC,20846,HRNR,isa,FPLX,000426,S100A
+HGNC,10486,S100A1,isa,FPLX,000426,S100A
+HGNC,10487,S100A10,isa,FPLX,000426,S100A
+HGNC,10488,S100A11,isa,FPLX,000426,S100A
+HGNC,10489,S100A12,isa,FPLX,000426,S100A
+HGNC,10490,S100A13,isa,FPLX,000426,S100A
+HGNC,18901,S100A14,isa,FPLX,000426,S100A
+HGNC,20441,S100A16,isa,FPLX,000426,S100A
+HGNC,10492,S100A2,isa,FPLX,000426,S100A
+HGNC,10493,S100A3,isa,FPLX,000426,S100A
+HGNC,10494,S100A4,isa,FPLX,000426,S100A
+HGNC,10495,S100A5,isa,FPLX,000426,S100A
+HGNC,10496,S100A6,isa,FPLX,000426,S100A
+HGNC,10497,S100A7,isa,FPLX,000426,S100A
+HGNC,21657,S100A7A,isa,FPLX,000426,S100A
+HGNC,10498,S100A8,isa,FPLX,000426,S100A
+HGNC,10499,S100A9,isa,FPLX,000426,S100A
+HGNC,31796,TCHHL1,isa,FPLX,000426,S100A
+FPLX,000426,S100A,isa,FPLX,000425,S100
+HGNC,10500,S100B,isa,FPLX,000425,S100
+HGNC,1436,S100G,isa,FPLX,000425,S100
+HGNC,10504,S100P,isa,FPLX,000425,S100
+HGNC,30367,S100Z,isa,FPLX,000425,S100
+HGNC,3165,S1PR1,isa,FPLX,000427,S1PR
+HGNC,3169,S1PR2,isa,FPLX,000427,S1PR
+HGNC,3167,S1PR3,isa,FPLX,000427,S1PR
+HGNC,3170,S1PR4,isa,FPLX,000427,S1PR
+HGNC,14299,S1PR5,isa,FPLX,000427,S1PR
+HGNC,10571,SCD,isa,FPLX,000429,SCD
+HGNC,21088,SCD5,isa,FPLX,000429,SCD
+HGNC,3311,SERPINB1,isa,FPLX,000431,SERPINB
+HGNC,8584,SERPINB2,isa,FPLX,000431,SERPINB
+HGNC,10569,SERPINB3,isa,FPLX,000431,SERPINB
+HGNC,10570,SERPINB4,isa,FPLX,000431,SERPINB
+HGNC,8949,SERPINB5,isa,FPLX,000431,SERPINB
+HGNC,8950,SERPINB6,isa,FPLX,000431,SERPINB
+HGNC,13902,SERPINB7,isa,FPLX,000431,SERPINB
+HGNC,8952,SERPINB8,isa,FPLX,000431,SERPINB
+HGNC,8955,SERPINB9,isa,FPLX,000431,SERPINB
+HGNC,8942,SERPINB10,isa,FPLX,000431,SERPINB
+HGNC,14221,SERPINB11,isa,FPLX,000431,SERPINB
+HGNC,14220,SERPINB12,isa,FPLX,000431,SERPINB
+HGNC,8944,SERPINB13,isa,FPLX,000431,SERPINB
+HGNC,11005,SLC2A1,isa,FPLX,000434,SLC2A
+HGNC,11006,SLC2A2,isa,FPLX,000434,SLC2A
+HGNC,11007,SLC2A3,isa,FPLX,000434,SLC2A
+HGNC,11009,SLC2A4,isa,FPLX,000434,SLC2A
+HGNC,11010,SLC2A5,isa,FPLX,000434,SLC2A
+HGNC,11011,SLC2A6,isa,FPLX,000434,SLC2A
+HGNC,13445,SLC2A7,isa,FPLX,000434,SLC2A
+HGNC,13812,SLC2A8,isa,FPLX,000434,SLC2A
+HGNC,13446,SLC2A9,isa,FPLX,000434,SLC2A
+HGNC,13444,SLC2A10,isa,FPLX,000434,SLC2A
+HGNC,14239,SLC2A11,isa,FPLX,000434,SLC2A
+HGNC,18067,SLC2A12,isa,FPLX,000434,SLC2A
+HGNC,18301,SLC2A14,isa,FPLX,000434,SLC2A
+HGNC,6767,SMAD1,isa,FPLX,000441,SMAD
+HGNC,6767,SMAD1,isa,FPLX,000442,SMAD1_5_9
+HGNC,6768,SMAD2,isa,FPLX,000443,SMAD2_3
+HGNC,6769,SMAD3,isa,FPLX,000443,SMAD2_3
+HGNC,6770,SMAD4,isa,FPLX,000441,SMAD
+HGNC,6771,SMAD5,isa,FPLX,000441,SMAD
+HGNC,6771,SMAD5,isa,FPLX,000442,SMAD1_5_9
+HGNC,6772,SMAD6,isa,FPLX,000441,SMAD
+HGNC,6773,SMAD7,isa,FPLX,000441,SMAD
+HGNC,6774,SMAD9,isa,FPLX,000441,SMAD
+HGNC,6774,SMAD9,isa,FPLX,000442,SMAD1_5_9
+FPLX,000443,SMAD2_3,isa,FPLX,000441,SMAD
+FPLX,000442,SMAD1_5_9,isa,FPLX,000441,SMAD
+HGNC,11111,SMC1A,isa,FPLX,000444,SMC1
+HGNC,11112,SMC1B,isa,FPLX,000444,SMC1
+HGNC,11128,SNAI1,isa,FPLX,000446,SNAI
+HGNC,11094,SNAI2,isa,FPLX,000446,SNAI
+HGNC,18411,SNAI3,isa,FPLX,000446,SNAI
+HGNC,3697,FGR,isa,FPLX,000451,SRC
+HGNC,4037,FYN,isa,FPLX,000451,SRC
+HGNC,11283,SRC,isa,FPLX,000451,SRC
+HGNC,12841,YES1,isa,FPLX,000451,SRC
+HGNC,11289,SREBF1,isa,FPLX,000452,SREBF
+HGNC,11290,SREBF2,isa,FPLX,000452,SREBF
+HGNC,43,TAP1,isa,FPLX,000459,TAP
+HGNC,44,TAP2,isa,FPLX,000459,TAP
+HGNC,50,ABCB9,isa,FPLX,000459,TAP
+HGNC,6551,LEF1,isa,FPLX,000460,TCF_LEF
+HGNC,11639,TCF7,isa,FPLX,000460,TCF_LEF
+HGNC,11640,TCF7L1,isa,FPLX,000460,TCF_LEF
+HGNC,11641,TCF7L2,isa,FPLX,000460,TCF_LEF
+HGNC,11742,TFAP2A,isa,FPLX,000463,TFAP2
+HGNC,11743,TFAP2B,isa,FPLX,000463,TFAP2
+HGNC,11744,TFAP2C,isa,FPLX,000463,TFAP2
+HGNC,15581,TFAP2D,isa,FPLX,000463,TFAP2
+HGNC,30774,TFAP2E,isa,FPLX,000463,TFAP2
+HGNC,11766,TGFB1,isa,FPLX,000465,TGFB
+HGNC,11768,TGFB2,isa,FPLX,000465,TGFB
+HGNC,11769,TGFB3,isa,FPLX,000465,TGFB
+HGNC,11772,TGFBR1,isa,FPLX,000466,TGFBR
+HGNC,11773,TGFBR2,isa,FPLX,000466,TGFBR
+HGNC,11774,TGFBR3,isa,FPLX,000466,TGFBR
+HGNC,11785,THBS1,isa,FPLX,000467,THBS
+HGNC,11786,THBS2,isa,FPLX,000467,THBS
+HGNC,11787,THBS3,isa,FPLX,000467,THBS
+HGNC,11788,THBS4,isa,FPLX,000467,THBS
+HGNC,2227,COMP,isa,FPLX,000467,THBS
+HGNC,11796,THRA,isa,FPLX,000468,THR
+HGNC,11799,THRB,isa,FPLX,000468,THR
+HGNC,5318,TNC,isa,FPLX,000473,TN
+HGNC,22942,TNN,isa,FPLX,000473,TN
+HGNC,11953,TNR,isa,FPLX,000473,TN
+HGNC,11976,TNXB,isa,FPLX,000473,TN
+HGNC,11989,TOP2A,isa,FPLX,000476,TOP2
+HGNC,11990,TOP2B,isa,FPLX,000476,TOP2
+HGNC,12019,TPSAB1,isa,FPLX,000481,Tryptase
+HGNC,14120,TPSB2,isa,FPLX,000481,Tryptase
+HGNC,14118,TPSD1,isa,FPLX,000481,Tryptase
+HGNC,14134,TPSG1,isa,FPLX,000481,Tryptase
+HGNC,12435,TXN,isa,FPLX,000487,TXN
+HGNC,17772,TXN2,isa,FPLX,000487,TXN
+HGNC,12437,TXNRD1,isa,FPLX,000488,TXNRD
+HGNC,18155,TXNRD2,isa,FPLX,000488,TXNRD
+HGNC,20667,TXNRD3,isa,FPLX,000488,TXNRD
+HGNC,1734,CDC34,isa,FPLX,000489,UBE2
+HGNC,12472,UBE2A,isa,FPLX,000489,UBE2
+HGNC,12473,UBE2B,isa,FPLX,000489,UBE2
+HGNC,15937,UBE2C,isa,FPLX,000489,UBE2
+HGNC,12474,UBE2D1,isa,FPLX,000489,UBE2
+HGNC,12475,UBE2D2,isa,FPLX,000489,UBE2
+HGNC,12476,UBE2D3,isa,FPLX,000489,UBE2
+HGNC,21647,UBE2D4,isa,FPLX,000489,UBE2
+HGNC,12477,UBE2E1,isa,FPLX,000489,UBE2
+HGNC,12478,UBE2E2,isa,FPLX,000489,UBE2
+HGNC,12479,UBE2E3,isa,FPLX,000489,UBE2
+HGNC,12480,UBE2F,isa,FPLX,000489,UBE2
+HGNC,12482,UBE2G1,isa,FPLX,000489,UBE2
+HGNC,12483,UBE2G2,isa,FPLX,000489,UBE2
+HGNC,12484,UBE2H,isa,FPLX,000489,UBE2
+HGNC,12485,UBE2I,isa,FPLX,000489,UBE2
+HGNC,17598,UBE2J1,isa,FPLX,000489,UBE2
+HGNC,19268,UBE2J2,isa,FPLX,000489,UBE2
+HGNC,12488,UBE2L3,isa,FPLX,000489,UBE2
+HGNC,12490,UBE2L6,isa,FPLX,000489,UBE2
+HGNC,12491,UBE2M,isa,FPLX,000489,UBE2
+HGNC,12492,UBE2N,isa,FPLX,000489,UBE2
+HGNC,31710,UBE2NL,isa,FPLX,000489,UBE2
+HGNC,15698,UBE2Q1,isa,FPLX,000489,UBE2
+HGNC,19907,UBE2R2,isa,FPLX,000489,UBE2
+HGNC,17895,UBE2S,isa,FPLX,000489,UBE2
+HGNC,12494,UBE2V1,isa,FPLX,000489,UBE2
+HGNC,12495,UBE2V2,isa,FPLX,000489,UBE2
+HGNC,25616,UBE2W,isa,FPLX,000489,UBE2
+HGNC,12657,VAV1,isa,FPLX,000494,VAV
+HGNC,12658,VAV2,isa,FPLX,000494,VAV
+HGNC,12659,VAV3,isa,FPLX,000494,VAV
+HGNC,12680,VEGFA,isa,FPLX,000495,VEGF
+HGNC,12681,VEGFB,isa,FPLX,000495,VEGF
+HGNC,12682,VEGFC,isa,FPLX,000495,VEGF
+HGNC,3708,VEGFD,isa,FPLX,000495,VEGF
+HGNC,8893,PGF,isa,FPLX,000495,VEGF
+HGNC,3763,FLT1,isa,FPLX,000496,VEGFR
+HGNC,3767,FLT4,isa,FPLX,000496,VEGFR
+HGNC,6307,KDR,isa,FPLX,000496,VEGFR
+HGNC,76,ABL1,isa,FPLX,000003,ABL_family
+HGNC,77,ABL2,isa,FPLX,000003,ABL_family
+HGNC,5309,HUS1,partof,FPLX,000001,9_1_1
+HGNC,9806,RAD1,partof,FPLX,000001,9_1_1
+HGNC,9827,RAD9A,partof,FPLX,000001,9_1_1
+HGNC,566,AP3B1,partof,FPLX,000016,Adaptor_protein_III
+HGNC,568,AP3D1,partof,FPLX,000016,Adaptor_protein_III
+HGNC,2013,AP3S1,partof,FPLX,000016,Adaptor_protein_III
+HGNC,571,AP3S2,partof,FPLX,000016,Adaptor_protein_III
+HGNC,537,ANXA2,partof,FPLX,000047,Annexin_II_heterotetramer
+HGNC,10487,S100A10,partof,FPLX,000047,Annexin_II_heterotetramer
+HGNC,703,ARPC1A,partof,FPLX,000054,Arp2_3_protein
+HGNC,704,ARPC1B,partof,FPLX,000054,Arp2_3_protein
+HGNC,705,ARPC2,partof,FPLX,000054,Arp2_3_protein
+HGNC,706,ARPC3,partof,FPLX,000054,Arp2_3_protein
+HGNC,707,ARPC4,partof,FPLX,000054,Arp2_3_protein
+HGNC,708,ARPC5,partof,FPLX,000054,Arp2_3_protein
+HGNC,23366,ARPC5L,partof,FPLX,000054,Arp2_3_protein
+HGNC,986,BCKDHA,partof,FPLX,000064,BCKDC
+HGNC,987,BCKDHB,partof,FPLX,000064,BCKDC
+HGNC,2698,DBT,partof,FPLX,000064,BCKDC
+HGNC,2898,DLD,partof,FPLX,000064,BCKDC
+HGNC,1241,C1QA,partof,FPLX,000072,C1
+HGNC,1242,C1QB,partof,FPLX,000072,C1
+HGNC,1245,C1QC,partof,FPLX,000072,C1
+HGNC,1246,C1R,partof,FPLX,000072,C1
+HGNC,1247,C1S,partof,FPLX,000072,C1
+HGNC,1241,C1QA,partof,FPLX,000073,C1q
+HGNC,1242,C1QB,partof,FPLX,000073,C1q
+HGNC,1460,CAMK2A,partof,FPLX,000077,CAMK2_complex
+HGNC,1461,CAMK2B,partof,FPLX,000077,CAMK2_complex
+HGNC,1462,CAMK2D,partof,FPLX,000077,CAMK2_complex
+HGNC,1463,CAMK2G,partof,FPLX,000077,CAMK2_complex
+HGNC,10899,SKP1,partof,FPLX,000084,CBF3
+HGNC,1615,CCT2,partof,FPLX,000085,CCT_complex
+HGNC,1616,CCT3,partof,FPLX,000085,CCT_complex
+HGNC,1617,CCT4,partof,FPLX,000085,CCT_complex
+HGNC,1618,CCT5,partof,FPLX,000085,CCT_complex
+HGNC,1620,CCT6A,partof,FPLX,000085,CCT_complex
+HGNC,1621,CCT6B,partof,FPLX,000085,CCT_complex
+HGNC,1622,CCT7,partof,FPLX,000085,CCT_complex
+HGNC,1623,CCT8,partof,FPLX,000085,CCT_complex
+HGNC,11655,TCP1,partof,FPLX,000085,CCT_complex
+HGNC,1677,CD247,partof,FPLX,000087,CD3
+HGNC,1673,CD3D,partof,FPLX,000087,CD3
+HGNC,1674,CD3E,partof,FPLX,000087,CD3
+HGNC,1675,CD3G,partof,FPLX,000087,CD3
+HGNC,1956,CHRNA2,partof,FPLX,000103,CHRN
+HGNC,1957,CHRNA3,partof,FPLX,000103,CHRN
+HGNC,1958,CHRNA4,partof,FPLX,000103,CHRN
+HGNC,1959,CHRNA5,partof,FPLX,000103,CHRN
+HGNC,15963,CHRNA6,partof,FPLX,000103,CHRN
+HGNC,1960,CHRNA7,partof,FPLX,000103,CHRN
+HGNC,1962,CHRNB2,partof,FPLX,000103,CHRN
+HGNC,1963,CHRNB3,partof,FPLX,000103,CHRN
+HGNC,1964,CHRNB4,partof,FPLX,000103,CHRN
+HGNC,2090,CLTA,partof,FPLX,000105,Clathrin
+HGNC,2091,CLTB,partof,FPLX,000105,Clathrin
+HGNC,2092,CLTC,partof,FPLX,000105,Clathrin
+HGNC,9811,RAD21,partof,FPLX,000108,Cohesin
+HGNC,2468,SMC3,partof,FPLX,000108,Cohesin
+HGNC,9234,MED1,partof,FPLX,000122,CRSP
+HGNC,2370,MED14,partof,FPLX,000122,CRSP
+HGNC,2375,MED17,partof,FPLX,000122,CRSP
+HGNC,2372,MED23,partof,FPLX,000122,CRSP
+HGNC,2376,MED26,partof,FPLX,000122,CRSP
+HGNC,2377,MED27,partof,FPLX,000122,CRSP
+HGNC,2378,MED7,partof,FPLX,000122,CRSP
+HGNC,2961,DYNC1H1,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,2963,DYNC1I1,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,2964,DYNC1I2,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,18745,DYNC1LI1,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,2966,DYNC1LI2,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,15476,DYNLL1,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,15468,DYNLRB1,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,15467,DYNLRB2,partof,FPLX,000135,Cytoplasmic_dynein
+HGNC,9175,POLD1,partof,FPLX,000141,DNA_polymerase_delta
+HGNC,9176,POLD2,partof,FPLX,000141,DNA_polymerase_delta
+HGNC,20932,POLD3,partof,FPLX,000141,DNA_polymerase_delta
+HGNC,14106,POLD4,partof,FPLX,000141,DNA_polymerase_delta
+HGNC,2666,DAG1,partof,FPLX,000139,DGC
+HGNC,2928,DMD,partof,FPLX,000139,DGC
+HGNC,3057,DTNA,partof,FPLX,000139,DGC
+HGNC,3058,DTNB,partof,FPLX,000139,DGC
+HGNC,7872,NOS1,partof,FPLX,000139,DGC
+HGNC,10805,SGCA,partof,FPLX,000139,DGC
+HGNC,10806,SGCB,partof,FPLX,000139,DGC
+HGNC,10807,SGCD,partof,FPLX,000139,DGC
+HGNC,10808,SGCE,partof,FPLX,000139,DGC
+HGNC,14075,SGCZ,partof,FPLX,000139,DGC
+HGNC,11167,SNTA1,partof,FPLX,000139,DGC
+HGNC,11168,SNTB1,partof,FPLX,000139,DGC
+HGNC,13740,SNTG1,partof,FPLX,000139,DGC
+HGNC,13741,SNTG2,partof,FPLX,000139,DGC
+HGNC,11322,SSPN,partof,FPLX,000139,DGC
+HGNC,12635,UTRN,partof,FPLX,000139,DGC
+HGNC,3257,EIF2B1,partof,FPLX,000152,EIF2B
+HGNC,3258,EIF2B2,partof,FPLX,000152,EIF2B
+HGNC,3259,EIF2B3,partof,FPLX,000152,EIF2B
+HGNC,3260,EIF2B4,partof,FPLX,000152,EIF2B
+HGNC,3261,EIF2B5,partof,FPLX,000152,EIF2B
+HGNC,3661,FGA,partof,FPLX,000169,Fibrinogen
+HGNC,3662,FGB,partof,FPLX,000169,Fibrinogen
+HGNC,3694,FGG,partof,FPLX,000169,Fibrinogen
+HGNC,1885,CGA,partof,FPLX,000175,FSH
+HGNC,3964,FSHB,partof,FPLX,000175,FSH
+HGNC,29509,APH1A,partof,FPLX,000181,Gamma_secretase
+HGNC,9508,PSEN1,partof,FPLX,000181,Gamma_secretase
+HGNC,30100,PSENEN,partof,FPLX,000181,Gamma_secretase
+HGNC,4446,GPAA1,partof,FPLX,000189,GPIT
+HGNC,8965,PIGK,partof,FPLX,000189,GPIT
+HGNC,14937,PIGS,partof,FPLX,000189,GPIT
+HGNC,14938,PIGT,partof,FPLX,000189,GPIT
+HGNC,15791,PIGU,partof,FPLX,000189,GPIT
+HGNC,4650,GTF2E1,partof,FPLX,000196,GTF2E
+HGNC,4651,GTF2E2,partof,FPLX,000196,GTF2E
+HGNC,4652,GTF2F1,partof,FPLX,000197,GTF2F
+HGNC,4653,GTF2F2,partof,FPLX,000197,GTF2F
+HGNC,399,ALB,partof,FPLX,000225,HDL
+HGNC,600,APOA1,partof,FPLX,000225,HDL
+HGNC,601,APOA2,partof,FPLX,000225,HDL
+HGNC,613,APOE,partof,FPLX,000225,HDL
+HGNC,2095,CLU,partof,FPLX,000225,HDL
+HGNC,4823,HBA1,partof,FPLX,000227,Hemoglobin
+HGNC,4824,HBA2,partof,FPLX,000227,Hemoglobin
+HGNC,4827,HBB,partof,FPLX,000227,Hemoglobin
+HGNC,4829,HBD,partof,FPLX,000227,Hemoglobin
+HGNC,4830,HBE1,partof,FPLX,000227,Hemoglobin
+HGNC,4831,HBG1,partof,FPLX,000227,Hemoglobin
+HGNC,4832,HBG2,partof,FPLX,000227,Hemoglobin
+HGNC,4826,HBM,partof,FPLX,000227,Hemoglobin
+HGNC,4833,HBQ1,partof,FPLX,000227,Hemoglobin
+HGNC,4835,HBZ,partof,FPLX,000227,Hemoglobin
+HGNC,4439,GP1BA,partof,FPLX,000188,GPIb_IX_V
+HGNC,4440,GP1BB,partof,FPLX,000188,GPIb_IX_V
+HGNC,4443,GP5,partof,FPLX,000188,GPIb_IX_V
+HGNC,4444,GP9,partof,FPLX,000188,GPIb_IX_V
+HGNC,1974,CHUK,partof,FPLX,000250,IKK_complex
+HGNC,5960,IKBKB,partof,FPLX,000250,IKK_complex
+HGNC,5961,IKBKG,partof,FPLX,000250,IKK_complex
+HGNC,5439,IFNGR1,partof,FPLX,000263,Interferon_gamma_receptor
+HGNC,5440,IFNGR2,partof,FPLX,000263,Interferon_gamma_receptor
+HGNC,1148,BUB1,partof,FPLX,000270,Kinetochore
+HGNC,1149,BUB1B,partof,FPLX,000270,Kinetochore
+HGNC,1151,BUB3,partof,FPLX,000270,Kinetochore
+HGNC,1854,CENPC,partof,FPLX,000270,Kinetochore
+HGNC,1856,CENPE,partof,FPLX,000270,Kinetochore
+HGNC,1857,CENPF,partof,FPLX,000270,Kinetochore
+HGNC,17268,CENPH,partof,FPLX,000270,Kinetochore
+HGNC,2712,DCTN2,partof,FPLX,000270,Kinetochore
+HGNC,6391,KIF22,partof,FPLX,000270,Kinetochore
+HGNC,6763,MAD2L1,partof,FPLX,000270,Kinetochore
+HGNC,8574,PAFAH1B1,partof,FPLX,000270,Kinetochore
+HGNC,9508,PSEN1,partof,FPLX,000270,Kinetochore
+HGNC,9509,PSEN2,partof,FPLX,000270,Kinetochore
+HGNC,11111,SMC1A,partof,FPLX,000270,Kinetochore
+HGNC,16987,SUGT1,partof,FPLX,000270,Kinetochore
+HGNC,11124,SUMO3,partof,FPLX,000270,Kinetochore
+HGNC,13194,ZW10,partof,FPLX,000270,Kinetochore
+HGNC,6481,LAMA1,partof,FPLX,000273,Laminin_111
+HGNC,6486,LAMB1,partof,FPLX,000273,Laminin_111
+HGNC,6492,LAMC1,partof,FPLX,000273,Laminin_111
+HGNC,6483,LAMA3,partof,FPLX,000274,Laminin_332
+HGNC,6490,LAMB3,partof,FPLX,000274,Laminin_332
+HGNC,6493,LAMC2,partof,FPLX,000274,Laminin_332
+HGNC,1885,CGA,partof,FPLX,000276,LH
+HGNC,6584,LHB,partof,FPLX,000276,LH
+HGNC,1331,C5,partof,FPLX,000278,MAC
+HGNC,1339,C6,partof,FPLX,000278,MAC
+HGNC,1346,C7,partof,FPLX,000278,MAC
+HGNC,1352,C8A,partof,FPLX,000278,MAC
+HGNC,1353,C8B,partof,FPLX,000278,MAC
+HGNC,1354,C8G,partof,FPLX,000278,MAC
+HGNC,1358,C9,partof,FPLX,000278,MAC
+HGNC,799,ATP1A1,isa,FPLX,000057,ATP1A
+HGNC,800,ATP1A2,isa,FPLX,000057,ATP1A
+HGNC,801,ATP1A3,isa,FPLX,000057,ATP1A
+HGNC,14073,ATP1A4,isa,FPLX,000057,ATP1A
+HGNC,804,ATP1B1,isa,FPLX,000058,ATP1B
+HGNC,805,ATP1B2,isa,FPLX,000058,ATP1B
+HGNC,806,ATP1B3,isa,FPLX,000058,ATP1B
+HGNC,808,ATP1B4,isa,FPLX,000058,ATP1B
+FPLX,000057,ATP1A,partof,FPLX,000303,Na_K_ATPase
+FPLX,000058,ATP1B,partof,FPLX,000303,Na_K_ATPase
+HGNC,7455,MT-ND1,partof,FPLX,000301,NADH_dehydrogenase
+HGNC,7456,MT-ND2,partof,FPLX,000301,NADH_dehydrogenase
+HGNC,7458,MT-ND3,partof,FPLX,000301,NADH_dehydrogenase
+HGNC,7459,MT-ND4,partof,FPLX,000301,NADH_dehydrogenase
+HGNC,7460,MT-ND4L,partof,FPLX,000301,NADH_dehydrogenase
+HGNC,7461,MT-ND5,partof,FPLX,000301,NADH_dehydrogenase
+HGNC,7462,MT-ND6,partof,FPLX,000301,NADH_dehydrogenase
+HGNC,2577,CYBA,partof,FPLX,000302,NADPH_oxidase
+HGNC,2578,CYBB,partof,FPLX,000302,NADPH_oxidase
+HGNC,3062,DUOX1,partof,FPLX,000302,NADPH_oxidase
+HGNC,13273,DUOX2,partof,FPLX,000302,NADPH_oxidase
+HGNC,7660,NCF1,partof,FPLX,000302,NADPH_oxidase
+HGNC,7661,NCF2,partof,FPLX,000302,NADPH_oxidase
+HGNC,7662,NCF4,partof,FPLX,000302,NADPH_oxidase
+HGNC,7889,NOX1,partof,FPLX,000302,NADPH_oxidase
+HGNC,7890,NOX3,partof,FPLX,000302,NADPH_oxidase
+HGNC,7891,NOX4,partof,FPLX,000302,NADPH_oxidase
+HGNC,14874,NOX5,partof,FPLX,000302,NADPH_oxidase
+HGNC,9801,RAC1,partof,FPLX,000302,NADPH_oxidase
+HGNC,7804,NFYA,partof,FPLX,000314,NFY
+HGNC,7805,NFYB,partof,FPLX,000314,NFY
+HGNC,7806,NFYC,partof,FPLX,000314,NFY
+HGNC,1442,CALM1,partof,FPLX,000356,PhK
+HGNC,8925,PHKA1,partof,FPLX,000356,PhK
+HGNC,8926,PHKA2,partof,FPLX,000356,PhK
+HGNC,8927,PHKB,partof,FPLX,000356,PhK
+HGNC,8930,PHKG1,partof,FPLX,000356,PhK
+HGNC,8931,PHKG2,partof,FPLX,000356,PhK
+HGNC,1066,BMI1,partof,FPLX,000386,PRC1_complex
+HGNC,1552,CBX2,partof,FPLX,000386,PRC1_complex
+HGNC,1554,CBX4,partof,FPLX,000386,PRC1_complex
+HGNC,15962,CBX8,partof,FPLX,000386,PRC1_complex
+HGNC,12929,PCGF2,partof,FPLX,000386,PRC1_complex
+HGNC,3182,PHC1,partof,FPLX,000386,PRC1_complex
+HGNC,3183,PHC2,partof,FPLX,000386,PRC1_complex
+HGNC,15682,PHC3,partof,FPLX,000386,PRC1_complex
+HGNC,8919,PHF1,partof,FPLX,000386,PRC1_complex
+HGNC,10018,RING1,partof,FPLX,000386,PRC1_complex
+HGNC,10061,RNF2,partof,FPLX,000386,PRC1_complex
+HGNC,19003,SCMH1,partof,FPLX,000386,PRC1_complex
+HGNC,12856,YY1,partof,FPLX,000386,PRC1_complex
+HGNC,12918,ZNF134,partof,FPLX,000386,PRC1_complex
+HGNC,3188,EED,partof,FPLX,000387,PRC2_complex
+HGNC,3526,EZH1,partof,FPLX,000387,PRC2_complex
+HGNC,3527,EZH2,partof,FPLX,000387,PRC2_complex
+HGNC,17101,SUZ12,partof,FPLX,000387,PRC2_complex
+HGNC,8653,PCCA,partof,FPLX,000392,Propionyl_CoA_carboxylase
+HGNC,8654,PCCB,partof,FPLX,000392,Propionyl_CoA_carboxylase
+HGNC,9530,PSMA1,partof,FPLX,000394,Proteasome
+HGNC,9531,PSMA2,partof,FPLX,000394,Proteasome
+HGNC,9532,PSMA3,partof,FPLX,000394,Proteasome
+HGNC,9533,PSMA4,partof,FPLX,000394,Proteasome
+HGNC,9534,PSMA5,partof,FPLX,000394,Proteasome
+HGNC,9535,PSMA6,partof,FPLX,000394,Proteasome
+HGNC,9536,PSMA7,partof,FPLX,000394,Proteasome
+HGNC,22985,PSMA8,partof,FPLX,000394,Proteasome
+HGNC,9537,PSMB1,partof,FPLX,000394,Proteasome
+HGNC,9538,PSMB10,partof,FPLX,000394,Proteasome
+HGNC,9539,PSMB2,partof,FPLX,000394,Proteasome
+HGNC,9540,PSMB3,partof,FPLX,000394,Proteasome
+HGNC,9541,PSMB4,partof,FPLX,000394,Proteasome
+HGNC,9542,PSMB5,partof,FPLX,000394,Proteasome
+HGNC,9543,PSMB6,partof,FPLX,000394,Proteasome
+HGNC,9544,PSMB7,partof,FPLX,000394,Proteasome
+HGNC,9545,PSMB8,partof,FPLX,000394,Proteasome
+HGNC,9546,PSMB9,partof,FPLX,000394,Proteasome
+HGNC,9547,PSMC1,partof,FPLX,000394,Proteasome
+HGNC,9548,PSMC2,partof,FPLX,000394,Proteasome
+HGNC,9549,PSMC3,partof,FPLX,000394,Proteasome
+HGNC,9551,PSMC4,partof,FPLX,000394,Proteasome
+HGNC,9552,PSMC5,partof,FPLX,000394,Proteasome
+HGNC,9553,PSMC6,partof,FPLX,000394,Proteasome
+HGNC,9554,PSMD1,partof,FPLX,000394,Proteasome
+HGNC,9555,PSMD10,partof,FPLX,000394,Proteasome
+HGNC,9556,PSMD11,partof,FPLX,000394,Proteasome
+HGNC,9557,PSMD12,partof,FPLX,000394,Proteasome
+HGNC,9558,PSMD13,partof,FPLX,000394,Proteasome
+HGNC,16889,PSMD14,partof,FPLX,000394,Proteasome
+HGNC,9559,PSMD2,partof,FPLX,000394,Proteasome
+HGNC,9560,PSMD3,partof,FPLX,000394,Proteasome
+HGNC,9561,PSMD4,partof,FPLX,000394,Proteasome
+HGNC,9563,PSMD5,partof,FPLX,000394,Proteasome
+HGNC,9564,PSMD6,partof,FPLX,000394,Proteasome
+HGNC,9565,PSMD7,partof,FPLX,000394,Proteasome
+HGNC,9566,PSMD8,partof,FPLX,000394,Proteasome
+HGNC,9567,PSMD9,partof,FPLX,000394,Proteasome
+HGNC,9568,PSME1,partof,FPLX,000394,Proteasome
+HGNC,9569,PSME2,partof,FPLX,000394,Proteasome
+HGNC,9570,PSME3,partof,FPLX,000394,Proteasome
+HGNC,9571,PSMF1,partof,FPLX,000394,Proteasome
+HGNC,10845,SEM1,partof,FPLX,000394,Proteasome
+HGNC,12628,USP5,partof,FPLX,000394,Proteasome
+HGNC,2896,DLAT,partof,FPLX,000352,PDH
+HGNC,2898,DLD,partof,FPLX,000352,PDH
+HGNC,8806,PDHA1,partof,FPLX,000352,PDH
+HGNC,8807,PDHA2,partof,FPLX,000352,PDH
+HGNC,8808,PDHB,partof,FPLX,000352,PDH
+HGNC,21350,PDHX,partof,FPLX,000352,PDH
+HGNC,9969,RFC1,partof,FPLX,000411,RFC
+HGNC,9970,RFC2,partof,FPLX,000411,RFC
+HGNC,9971,RFC3,partof,FPLX,000411,RFC
+HGNC,9972,RFC4,partof,FPLX,000411,RFC
+HGNC,9973,RFC5,partof,FPLX,000411,RFC
+HGNC,17264,POLR1A,partof,FPLX,000416,RNApo_I
+HGNC,20454,POLR1B,partof,FPLX,000416,RNApo_I
+HGNC,20194,POLR1C,partof,FPLX,000416,RNApo_I
+HGNC,20422,POLR1D,partof,FPLX,000416,RNApo_I
+HGNC,9187,POLR2A,partof,FPLX,000417,RNApo_II
+HGNC,9188,POLR2B,partof,FPLX,000417,RNApo_II
+HGNC,9189,POLR2C,partof,FPLX,000417,RNApo_II
+HGNC,9191,POLR2D,partof,FPLX,000417,RNApo_II
+HGNC,9192,POLR2E,partof,FPLX,000417,RNApo_II
+HGNC,9193,POLR2F,partof,FPLX,000417,RNApo_II
+HGNC,9194,POLR2G,partof,FPLX,000417,RNApo_II
+HGNC,9195,POLR2H,partof,FPLX,000417,RNApo_II
+HGNC,9196,POLR2I,partof,FPLX,000417,RNApo_II
+HGNC,9197,POLR2J,partof,FPLX,000417,RNApo_II
+HGNC,23208,POLR2J2,partof,FPLX,000417,RNApo_II
+HGNC,9198,POLR2K,partof,FPLX,000417,RNApo_II
+HGNC,9199,POLR2L,partof,FPLX,000417,RNApo_II
+HGNC,3535,F2,partof,FPLX,000469,Thrombin_antithrombin
+HGNC,775,SERPINC1,partof,FPLX,000469,Thrombin_antithrombin
+HGNC,11532,TAF1A,partof,FPLX,000471,TIF_IB
+HGNC,11533,TAF1B,partof,FPLX,000471,TIF_IB
+HGNC,11534,TAF1C,partof,FPLX,000471,TIF_IB
+HGNC,11588,TBP,partof,FPLX,000471,TIF_IB
+HGNC,18752,MAPKAP1,partof,FPLX,000294,mTORC2
+HGNC,3942,MTOR,partof,FPLX,000294,mTORC2
+HGNC,28611,RICTOR,partof,FPLX,000294,mTORC2
+HGNC,24825,MLST8,partof,FPLX,000294,mTORC2
+HGNC,3942,MTOR,partof,FPLX,000293,mTORC1
+HGNC,30287,RPTOR,partof,FPLX,000293,mTORC1
+HGNC,11998,TP53,isa,FPLX,000327,p53_family
+HGNC,15979,TP63,isa,FPLX,000327,p53_family
+HGNC,12003,TP73,isa,FPLX,000327,p53_family
+HGNC,9585,PTCH1,isa,FPLX,000333,Patched
+HGNC,9586,PTCH2,isa,FPLX,000333,Patched
+HGNC,11943,TNNC1,isa,FPLX,000478,Troponin_C
+HGNC,11944,TNNC2,isa,FPLX,000478,Troponin_C
+HGNC,11945,TNNI1,isa,FPLX,000479,Troponin_I
+HGNC,11946,TNNI2,isa,FPLX,000479,Troponin_I
+HGNC,11947,TNNI3,isa,FPLX,000479,Troponin_I
+HGNC,11948,TNNT1,isa,FPLX,000480,Troponin_T
+HGNC,11949,TNNT2,isa,FPLX,000480,Troponin_T
+HGNC,11950,TNNT3,isa,FPLX,000480,Troponin_T
+FPLX,000478,Troponin_C,partof,FPLX,000477,Troponin
+FPLX,000479,Troponin_I,partof,FPLX,000477,Troponin
+FPLX,000480,Troponin_T,partof,FPLX,000477,Troponin
+HGNC,811,ATP2A1,isa,FPLX,000430,SERCA
+HGNC,812,ATP2A2,isa,FPLX,000430,SERCA
+HGNC,813,ATP2A3,isa,FPLX,000430,SERCA
+HGNC,8014,YBX1,isa,FPLX,000498,YBX
+HGNC,17948,YBX2,isa,FPLX,000498,YBX
+HGNC,2428,YBX3,isa,FPLX,000498,YBX
+HGNC,1925,CHEK1,isa,FPLX,000098,CHEK
+HGNC,16627,CHEK2,isa,FPLX,000098,CHEK
+HGNC,270,PARP1,isa,FPLX,000331,PARP
+HGNC,272,PARP2,isa,FPLX,000331,PARP
+HGNC,273,PARP3,isa,FPLX,000331,PARP
+HGNC,271,PARP4,isa,FPLX,000331,PARP
+HGNC,26921,PARP6,isa,FPLX,000331,PARP
+HGNC,26124,PARP8,isa,FPLX,000331,PARP
+HGNC,24118,PARP9,isa,FPLX,000331,PARP
+HGNC,25895,PARP10,isa,FPLX,000331,PARP
+HGNC,1186,PARP11,isa,FPLX,000331,PARP
+HGNC,21919,PARP12,isa,FPLX,000331,PARP
+HGNC,29232,PARP14,isa,FPLX,000331,PARP
+HGNC,26876,PARP15,isa,FPLX,000331,PARP
+HGNC,26040,PARP16,isa,FPLX,000331,PARP
+HGNC,11941,TNKS,isa,FPLX,000331,PARP
+HGNC,15677,TNKS2,isa,FPLX,000331,PARP
+HGNC,23696,TIPARP,isa,FPLX,000331,PARP
+HGNC,7781,NFE2L1,isa,FPLX,000310,NFE
+HGNC,7782,NFE2L2,isa,FPLX,000310,NFE
+HGNC,7783,NFE2L3,isa,FPLX,000310,NFE
+HGNC,1784,CDKN1A,isa,FPLX,000095,CDKN1
+HGNC,1785,CDKN1B,isa,FPLX,000095,CDKN1
+HGNC,1786,CDKN1C,isa,FPLX,000095,CDKN1
+HGNC,1787,CDKN2A,isa,FPLX,000096,CDKN2
+HGNC,1788,CDKN2B,isa,FPLX,000096,CDKN2
+HGNC,1789,CDKN2C,isa,FPLX,000096,CDKN2
+HGNC,1790,CDKN2D,isa,FPLX,000096,CDKN2
+FPLX,000095,CDKN1,isa,FPLX,000094,CDKN
+FPLX,000096,CDKN2,isa,FPLX,000094,CDKN
+HGNC,1791,CDKN3,isa,FPLX,000094,CDKN
+HGNC,678,ARHGDIA,isa,FPLX,000415,RhoGDI
+HGNC,679,ARHGDIB,isa,FPLX,000415,RhoGDI
+HGNC,680,ARHGDIG,isa,FPLX,000415,RhoGDI
+HGNC,10289,RPA1,partof,FPLX,000421,RPA
+HGNC,10290,RPA2,partof,FPLX,000421,RPA
+HGNC,10291,RPA3,partof,FPLX,000421,RPA
+HGNC,12027,TRA,partof,FPLX,000461,TCR
+HGNC,12155,TRB,partof,FPLX,000461,TCR
+HGNC,12252,TRD,partof,FPLX,000461,TCR
+HGNC,12271,TRG,partof,FPLX,000461,TCR
+HGNC,10249,ROBO1,isa,FPLX,000418,ROBO
+HGNC,10250,ROBO2,isa,FPLX,000418,ROBO
+HGNC,13433,ROBO3,isa,FPLX,000418,ROBO
+HGNC,11714,TEAD1,isa,FPLX,000462,TEAD
+HGNC,11715,TEAD2,isa,FPLX,000462,TEAD
+HGNC,11716,TEAD3,isa,FPLX,000462,TEAD
+HGNC,11717,TEAD4,isa,FPLX,000462,TEAD
+HGNC,16807,SMURF1,isa,FPLX,000445,SMURF
+HGNC,16809,SMURF2,isa,FPLX,000445,SMURF
+HGNC,3166,LPAR1,isa,FPLX,000277,LPAR
+HGNC,3168,LPAR2,isa,FPLX,000277,LPAR
+HGNC,14298,LPAR3,isa,FPLX,000277,LPAR
+HGNC,1044,BGN,isa,FPLX,000436,SLRP_1
+HGNC,2705,DCN,isa,FPLX,000436,SLRP_1
+HGNC,14872,ASPN,isa,FPLX,000436,SLRP_1
+HGNC,3154,ECM2,isa,FPLX,000436,SLRP_1
+HGNC,3774,FMOD,isa,FPLX,000437,SLRP_2
+HGNC,6724,LUM,isa,FPLX,000437,SLRP_2
+HGNC,9357,PRELP,isa,FPLX,000437,SLRP_2
+HGNC,6309,KERA,isa,FPLX,000437,SLRP_2
+HGNC,8134,OMD,isa,FPLX,000437,SLRP_2
+HGNC,3053,EPYC,isa,FPLX,000438,SLRP_3
+HGNC,8158,OPTC,isa,FPLX,000438,SLRP_3
+HGNC,8126,OGN,isa,FPLX,000438,SLRP_3
+HGNC,1909,CHAD,isa,FPLX,000439,SLRP_4
+HGNC,8082,NYX,isa,FPLX,000439,SLRP_4
+HGNC,28850,TSKU,isa,FPLX,000439,SLRP_4
+HGNC,23174,PODN,isa,FPLX,000440,SLRP_5
+HGNC,26275,PODNL1,isa,FPLX,000440,SLRP_5
+FPLX,000436,SLRP_1,isa,FPLX,000435,SLRP
+FPLX,000437,SLRP_2,isa,FPLX,000435,SLRP
+FPLX,000438,SLRP_3,isa,FPLX,000435,SLRP
+FPLX,000439,SLRP_4,isa,FPLX,000435,SLRP
+FPLX,000440,SLRP_5,isa,FPLX,000435,SLRP
+HGNC,8986,PIM1,isa,FPLX,000362,PIM
+HGNC,8987,PIM2,isa,FPLX,000362,PIM
+HGNC,19310,PIM3,isa,FPLX,000362,PIM
+HGNC,4579,GRIK1,isa,FPLX,000269,Kainate_family
+HGNC,4580,GRIK2,isa,FPLX,000269,Kainate_family
+HGNC,4581,GRIK3,isa,FPLX,000269,Kainate_family
+HGNC,4582,GRIK4,isa,FPLX,000269,Kainate_family
+HGNC,4583,GRIK5,isa,FPLX,000269,Kainate_family
+HGNC,8008,NRXN1,isa,FPLX,000308,Neurexins
+HGNC,8009,NRXN2,isa,FPLX,000308,Neurexins
+HGNC,8010,NRXN3,isa,FPLX,000308,Neurexins
+HGNC,6008,IL2RA,partof,FPLX,000255,IL2R
+HGNC,6009,IL2RB,partof,FPLX,000255,IL2R
+HGNC,6010,IL2RG,partof,FPLX,000255,IL2R
+HGNC,5978,IL15RA,partof,FPLX,000254,IL15R
+HGNC,6009,IL2RB,partof,FPLX,000254,IL15R
+HGNC,6010,IL2RG,partof,FPLX,000254,IL15R
+HGNC,14275,MRPL1,partof,FPLX,000290,MRPL
+HGNC,14056,MRPL2,partof,FPLX,000290,MRPL
+HGNC,10379,MRPL3,partof,FPLX,000290,MRPL
+HGNC,14276,MRPL4,partof,FPLX,000290,MRPL
+HGNC,14277,MRPL9,partof,FPLX,000290,MRPL
+HGNC,14055,MRPL10,partof,FPLX,000290,MRPL
+HGNC,14042,MRPL11,partof,FPLX,000290,MRPL
+HGNC,10378,MRPL12,partof,FPLX,000290,MRPL
+HGNC,14278,MRPL13,partof,FPLX,000290,MRPL
+HGNC,14279,MRPL14,partof,FPLX,000290,MRPL
+HGNC,14054,MRPL15,partof,FPLX,000290,MRPL
+HGNC,14476,MRPL16,partof,FPLX,000290,MRPL
+HGNC,14053,MRPL17,partof,FPLX,000290,MRPL
+HGNC,14477,MRPL18,partof,FPLX,000290,MRPL
+HGNC,14052,MRPL19,partof,FPLX,000290,MRPL
+HGNC,14478,MRPL20,partof,FPLX,000290,MRPL
+HGNC,14479,MRPL21,partof,FPLX,000290,MRPL
+HGNC,14480,MRPL22,partof,FPLX,000290,MRPL
+HGNC,10322,MRPL23,partof,FPLX,000290,MRPL
+HGNC,14037,MRPL24,partof,FPLX,000290,MRPL
+HGNC,14483,MRPL27,partof,FPLX,000290,MRPL
+HGNC,14484,MRPL28,partof,FPLX,000290,MRPL
+HGNC,14036,MRPL30,partof,FPLX,000290,MRPL
+HGNC,14035,MRPL32,partof,FPLX,000290,MRPL
+HGNC,14487,MRPL33,partof,FPLX,000290,MRPL
+HGNC,14488,MRPL34,partof,FPLX,000290,MRPL
+HGNC,14489,MRPL35,partof,FPLX,000290,MRPL
+HGNC,14490,MRPL36,partof,FPLX,000290,MRPL
+HGNC,14034,MRPL37,partof,FPLX,000290,MRPL
+HGNC,14033,MRPL38,partof,FPLX,000290,MRPL
+HGNC,14027,MRPL39,partof,FPLX,000290,MRPL
+HGNC,14491,MRPL40,partof,FPLX,000290,MRPL
+HGNC,14492,MRPL41,partof,FPLX,000290,MRPL
+HGNC,14493,MRPL42,partof,FPLX,000290,MRPL
+HGNC,14517,MRPL43,partof,FPLX,000290,MRPL
+HGNC,16650,MRPL44,partof,FPLX,000290,MRPL
+HGNC,16651,MRPL45,partof,FPLX,000290,MRPL
+HGNC,1192,MRPL46,partof,FPLX,000290,MRPL
+HGNC,16652,MRPL47,partof,FPLX,000290,MRPL
+HGNC,16653,MRPL48,partof,FPLX,000290,MRPL
+HGNC,1176,MRPL49,partof,FPLX,000290,MRPL
+HGNC,16654,MRPL50,partof,FPLX,000290,MRPL
+HGNC,14044,MRPL51,partof,FPLX,000290,MRPL
+HGNC,16655,MRPL52,partof,FPLX,000290,MRPL
+HGNC,16684,MRPL53,partof,FPLX,000290,MRPL
+HGNC,16685,MRPL54,partof,FPLX,000290,MRPL
+HGNC,16686,MRPL55,partof,FPLX,000290,MRPL
+HGNC,14514,MRPL57,partof,FPLX,000290,MRPL
+HGNC,14495,MRPS2,partof,FPLX,000289,MRPS
+HGNC,14498,MRPS5,partof,FPLX,000289,MRPS
+HGNC,14051,MRPS6,partof,FPLX,000289,MRPS
+HGNC,14499,MRPS7,partof,FPLX,000289,MRPS
+HGNC,14501,MRPS9,partof,FPLX,000289,MRPS
+HGNC,14502,MRPS10,partof,FPLX,000289,MRPS
+HGNC,14050,MRPS11,partof,FPLX,000289,MRPS
+HGNC,10380,MRPS12,partof,FPLX,000289,MRPS
+HGNC,14049,MRPS14,partof,FPLX,000289,MRPS
+HGNC,14504,MRPS15,partof,FPLX,000289,MRPS
+HGNC,14048,MRPS16,partof,FPLX,000289,MRPS
+HGNC,14047,MRPS17,partof,FPLX,000289,MRPS
+HGNC,14515,MRPS18A,partof,FPLX,000289,MRPS
+HGNC,14516,MRPS18B,partof,FPLX,000289,MRPS
+HGNC,16633,MRPS18C,partof,FPLX,000289,MRPS
+HGNC,14046,MRPS21,partof,FPLX,000289,MRPS
+HGNC,14508,MRPS22,partof,FPLX,000289,MRPS
+HGNC,14509,MRPS23,partof,FPLX,000289,MRPS
+HGNC,14510,MRPS24,partof,FPLX,000289,MRPS
+HGNC,14511,MRPS25,partof,FPLX,000289,MRPS
+HGNC,14045,MRPS26,partof,FPLX,000289,MRPS
+HGNC,14512,MRPS27,partof,FPLX,000289,MRPS
+HGNC,14513,MRPS28,partof,FPLX,000289,MRPS
+HGNC,2673,DAP3,partof,FPLX,000289,MRPS
+HGNC,8769,MRPS30,partof,FPLX,000289,MRPS
+HGNC,16632,MRPS31,partof,FPLX,000289,MRPS
+HGNC,16634,MRPS33,partof,FPLX,000289,MRPS
+HGNC,16618,MRPS34,partof,FPLX,000289,MRPS
+HGNC,16635,MRPS35,partof,FPLX,000289,MRPS
+HGNC,16631,MRPS36,partof,FPLX,000289,MRPS
+FPLX,000289,MRPS,partof,FPLX,000288,Mitochondrial_Ribosome
+FPLX,000290,MRPL,partof,FPLX,000288,Mitochondrial_Ribosome
+HGNC,7939,NPPA,isa,FPLX,000304,Natriuretic_peptide
+HGNC,7940,NPPB,isa,FPLX,000304,Natriuretic_peptide
+HGNC,7941,NPPC,isa,FPLX,000304,Natriuretic_peptide
+HGNC,7455,MT-ND1,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7456,MT-ND2,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7458,MT-ND3,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7459,MT-ND4,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7460,MT-ND4L,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7461,MT-ND5,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7462,MT-ND6,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7707,NDUFS1,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7708,NDUFS2,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7710,NDUFS3,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7714,NDUFS7,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7715,NDUFS8,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7716,NDUFV1,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7717,NDUFV2,partof,FPLX,000499,ETC_complex_I_core
+HGNC,7694,NDUFAB1,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7683,NDUFA1,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7685,NDUFA2,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7686,NDUFA3,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7688,NDUFA5,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7690,NDUFA6,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7691,NDUFA7,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7692,NDUFA8,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7693,NDUFA9,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7684,NDUFA10,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,20371,NDUFA11,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,23987,NDUFA12,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,17194,NDUFA13,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7695,NDUFB1,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7697,NDUFB2,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7698,NDUFB3,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7699,NDUFB4,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7700,NDUFB5,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7701,NDUFB6,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7702,NDUFB7,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7703,NDUFB8,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7704,NDUFB9,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7696,NDUFB10,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,20372,NDUFB11,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7705,NDUFC1,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7706,NDUFC2,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7711,NDUFS4,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7712,NDUFS5,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7713,NDUFS6,partof,FPLX,000500,ETC_complex_I_supernumerary
+HGNC,7719,NDUFV3,partof,FPLX,000500,ETC_complex_I_supernumerary
+FPLX,000499,ETC_complex_I_core,partof,FPLX,000501,ETC_complex_I
+FPLX,000500,ETC_complex_I_supernumerary,partof,FPLX,000501,ETC_complex_I
+HGNC,10680,SDHA,partof,FPLX,000502,ETC_complex_II
+HGNC,10681,SDHB,partof,FPLX,000502,ETC_complex_II
+HGNC,10682,SDHC,partof,FPLX,000502,ETC_complex_II
+HGNC,10683,SDHD,partof,FPLX,000502,ETC_complex_II
+HGNC,2579,CYC1,partof,FPLX,000503,ETC_complex_III
+HGNC,7427,MT-CYB,partof,FPLX,000503,ETC_complex_III
+HGNC,12582,UQCRB,partof,FPLX,000503,ETC_complex_III
+HGNC,12585,UQCRC1,partof,FPLX,000503,ETC_complex_III
+HGNC,12586,UQCRC2,partof,FPLX,000503,ETC_complex_III
+HGNC,12587,UQCRFS1,partof,FPLX,000503,ETC_complex_III
+HGNC,12590,UQCRH,partof,FPLX,000503,ETC_complex_III
+HGNC,29594,UQCRQ,partof,FPLX,000503,ETC_complex_III
+HGNC,30863,UQCR10,partof,FPLX,000503,ETC_complex_III
+HGNC,30862,UQCR11,partof,FPLX,000503,ETC_complex_III
+HGNC,2265,COX4I1,partof,FPLX,000504,ETC_complex_IV
+HGNC,16232,COX4I2,partof,FPLX,000504,ETC_complex_IV
+HGNC,2267,COX5A,partof,FPLX,000504,ETC_complex_IV
+HGNC,2269,COX5B,partof,FPLX,000504,ETC_complex_IV
+HGNC,2277,COX6A1,partof,FPLX,000504,ETC_complex_IV
+HGNC,2279,COX6A2,partof,FPLX,000504,ETC_complex_IV
+HGNC,2280,COX6B1,partof,FPLX,000504,ETC_complex_IV
+HGNC,24380,COX6B2,partof,FPLX,000504,ETC_complex_IV
+HGNC,2285,COX6C,partof,FPLX,000504,ETC_complex_IV
+HGNC,2287,COX7A1,partof,FPLX,000504,ETC_complex_IV
+HGNC,2288,COX7A2,partof,FPLX,000504,ETC_complex_IV
+HGNC,2291,COX7B,partof,FPLX,000504,ETC_complex_IV
+HGNC,24381,COX7B2,partof,FPLX,000504,ETC_complex_IV
+HGNC,2292,COX7C,partof,FPLX,000504,ETC_complex_IV
+HGNC,2294,COX8A,partof,FPLX,000504,ETC_complex_IV
+HGNC,24382,COX8C,partof,FPLX,000504,ETC_complex_IV
+HGNC,7419,MT-CO1,partof,FPLX,000504,ETC_complex_IV
+HGNC,7421,MT-CO2,partof,FPLX,000504,ETC_complex_IV
+HGNC,7422,MT-CO3,partof,FPLX,000504,ETC_complex_IV
+HGNC,823,ATP5F1A,partof,FPLX,000060,ATP_synthase
+HGNC,830,ATP5F1B,partof,FPLX,000060,ATP_synthase
+HGNC,833,ATP5F1C,partof,FPLX,000060,ATP_synthase
+HGNC,837,ATP5F1D,partof,FPLX,000060,ATP_synthase
+HGNC,838,ATP5F1E,partof,FPLX,000060,ATP_synthase
+HGNC,30889,ATP5MD,partof,FPLX,000060,ATP_synthase
+HGNC,846,ATP5ME,partof,FPLX,000060,ATP_synthase
+HGNC,848,ATP5MF,partof,FPLX,000060,ATP_synthase
+HGNC,14247,ATP5MG,partof,FPLX,000060,ATP_synthase
+HGNC,1188,ATP5MPL,partof,FPLX,000060,ATP_synthase
+HGNC,7414,MT-ATP6,partof,FPLX,000060,ATP_synthase
+HGNC,7415,MT-ATP8,partof,FPLX,000060,ATP_synthase
+HGNC,840,ATP5PB,partof,FPLX,000060,ATP_synthase
+HGNC,845,ATP5PD,partof,FPLX,000060,ATP_synthase
+HGNC,847,ATP5PF,partof,FPLX,000060,ATP_synthase
+HGNC,850,ATP5PO,partof,FPLX,000060,ATP_synthase
+HGNC,871,ATP5IF1,partof,FPLX,000060,ATP_synthase
+HGNC,841,ATP5MC1,isa,FPLX,000059,ATP5G
+HGNC,842,ATP5MC2,isa,FPLX,000059,ATP5G
+HGNC,843,ATP5MC3,isa,FPLX,000059,ATP5G
+FPLX,000059,ATP5G,partof,FPLX,000060,ATP_synthase
+HGNC,7393,MT1A,isa,FPLX,000292,Metallothionein
+HGNC,7394,MT1B,isa,FPLX,000292,Metallothionein
+HGNC,7395,MT1CP,isa,FPLX,000292,Metallothionein
+HGNC,7396,MT1DP,isa,FPLX,000292,Metallothionein
+HGNC,7397,MT1E,isa,FPLX,000292,Metallothionein
+HGNC,7398,MT1F,isa,FPLX,000292,Metallothionein
+HGNC,7399,MT1G,isa,FPLX,000292,Metallothionein
+HGNC,7400,MT1H,isa,FPLX,000292,Metallothionein
+HGNC,31864,MT1HL1,isa,FPLX,000292,Metallothionein
+HGNC,7401,MT1IP,isa,FPLX,000292,Metallothionein
+HGNC,7402,MT1JP,isa,FPLX,000292,Metallothionein
+HGNC,7404,MT1L,isa,FPLX,000292,Metallothionein
+HGNC,14296,MT1M,isa,FPLX,000292,Metallothionein
+HGNC,23681,MT1P1,isa,FPLX,000292,Metallothionein
+HGNC,16120,MT1P3,isa,FPLX,000292,Metallothionein
+HGNC,7405,MT1X,isa,FPLX,000292,Metallothionein
+HGNC,7406,MT2A,isa,FPLX,000292,Metallothionein
+HGNC,7408,MT3,isa,FPLX,000292,Metallothionein
+HGNC,18705,MT4,isa,FPLX,000292,Metallothionein
+HGNC,660,TRIM23,isa,FPLX,000053,ARF_GTPase_family
+HGNC,652,ARF1,isa,FPLX,000053,ARF_GTPase_family
+HGNC,654,ARF3,isa,FPLX,000053,ARF_GTPase_family
+HGNC,655,ARF4,isa,FPLX,000053,ARF_GTPase_family
+HGNC,658,ARF5,isa,FPLX,000053,ARF_GTPase_family
+HGNC,659,ARF6,isa,FPLX,000053,ARF_GTPase_family
+HGNC,692,ARL1,isa,FPLX,000053,ARF_GTPase_family
+HGNC,693,ARL2,isa,FPLX,000053,ARF_GTPase_family
+HGNC,694,ARL3,isa,FPLX,000053,ARF_GTPase_family
+HGNC,695,ARL4A,isa,FPLX,000053,ARF_GTPase_family
+HGNC,698,ARL4C,isa,FPLX,000053,ARF_GTPase_family
+HGNC,656,ARL4D,isa,FPLX,000053,ARF_GTPase_family
+HGNC,696,ARL5A,isa,FPLX,000053,ARF_GTPase_family
+HGNC,23052,ARL5B,isa,FPLX,000053,ARF_GTPase_family
+HGNC,31111,ARL5C,isa,FPLX,000053,ARF_GTPase_family
+HGNC,13210,ARL6,isa,FPLX,000053,ARF_GTPase_family
+HGNC,25192,ARL8A,isa,FPLX,000053,ARF_GTPase_family
+HGNC,25564,ARL8B,isa,FPLX,000053,ARF_GTPase_family
+HGNC,23592,ARL9,isa,FPLX,000053,ARF_GTPase_family
+HGNC,22042,ARL10,isa,FPLX,000053,ARF_GTPase_family
+HGNC,24046,ARL11,isa,FPLX,000053,ARF_GTPase_family
+HGNC,31709,ARL13A,isa,FPLX,000053,ARF_GTPase_family
+HGNC,25419,ARL13B,isa,FPLX,000053,ARF_GTPase_family
+HGNC,22974,ARL14,isa,FPLX,000053,ARF_GTPase_family
+HGNC,25945,ARL15,isa,FPLX,000053,ARF_GTPase_family
+HGNC,27902,ARL16,isa,FPLX,000053,ARF_GTPase_family
+HGNC,24096,ARL17A,isa,FPLX,000053,ARF_GTPase_family
+HGNC,32387,ARL17B,isa,FPLX,000053,ARF_GTPase_family
+HGNC,662,ARFRP1,isa,FPLX,000053,ARF_GTPase_family
+HGNC,10534,SAR1A,isa,FPLX,000053,ARF_GTPase_family
+HGNC,10535,SAR1B,isa,FPLX,000053,ARF_GTPase_family
+FPLX,000002,A4GALT_family,isa,FPLX,000198,Glycosyltransferase
+FPLX,000026,ALG10,isa,FPLX,000198,Glycosyltransferase
+FPLX,000027,ALG1_family,isa,FPLX,000198,Glycosyltransferase
+FPLX,000028,ALG3_family,isa,FPLX,000198,Glycosyltransferase
+FPLX,000029,ALG6_family,isa,FPLX,000198,Glycosyltransferase
+FPLX,000030,ALG13_family,isa,FPLX,000198,Glycosyltransferase
+FPLX,000063,B3GAT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000065,Beta_3_4_GTF,isa,FPLX,000198,Glycosyltransferase
+FPLX,000112,COLGALT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000165,EXT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000176,FUT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000180,GALNT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000185,GCNT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000199,GTF_family_2,isa,FPLX,000198,Glycosyltransferase
+FPLX,000200,GTF_family_6,isa,FPLX,000198,Glycosyltransferase
+FPLX,000201,GTF_family_8,isa,FPLX,000198,Glycosyltransferase
+FPLX,000202,GTF_family_29,isa,FPLX,000198,Glycosyltransferase
+FPLX,000203,GTF_family_90,isa,FPLX,000198,Glycosyltransferase
+FPLX,000287,MGAT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000322,OGT_family,isa,FPLX,000198,Glycosyltransferase
+FPLX,000396,PYG,isa,FPLX,000198,Glycosyltransferase
+FPLX,000455,STT3,isa,FPLX,000198,Glycosyltransferase
+FPLX,000491,UGCG,isa,FPLX,000198,Glycosyltransferase
+FPLX,000492,UGT,isa,FPLX,000198,Glycosyltransferase
+FPLX,000493,UGGT,isa,FPLX,000198,Glycosyltransferase
+HGNC,23162,ALG10,isa,FPLX,000026,ALG10
+HGNC,31088,ALG10B,isa,FPLX,000026,ALG10
+HGNC,23157,ALG6,isa,FPLX,000029,ALG6_family
+HGNC,23161,ALG8,isa,FPLX,000029,ALG6_family
+HGNC,18149,A4GALT,isa,FPLX,000002,A4GALT_family
+HGNC,17968,A4GNT,isa,FPLX,000002,A4GALT_family
+HGNC,921,B3GAT1,isa,FPLX,000063,B3GAT
+HGNC,922,B3GAT2,isa,FPLX,000063,B3GAT
+HGNC,923,B3GAT3,isa,FPLX,000063,B3GAT
+HGNC,918,B3GALNT1,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,28596,B3GALNT2,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,20207,B3GLCT,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,916,B3GALT1,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,917,B3GALT2,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,919,B3GALT4,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,920,B3GALT5,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,17978,B3GALT6,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,15629,B3GNT2,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,13528,B3GNT3,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,15683,B3GNT4,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,15684,B3GNT5,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24141,B3GNT6,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,18811,B3GNT7,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24139,B3GNT8,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,28714,B3GNT9,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24291,CHPF,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,29270,CHPF2,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,17198,CHSY1,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24293,CHSY3,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24337,C1GALT1,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,6560,LFNG,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,7038,MFNG,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,9974,RFNG,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,4117,B4GALNT1,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24136,B4GALNT2,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24137,B4GALNT3,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,26315,B4GALNT4,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,924,B4GALT1,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,925,B4GALT2,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,926,B4GALT3,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,927,B4GALT4,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,928,B4GALT5,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,929,B4GALT6,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,930,B4GALT7,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24290,CSGALNACT1,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,24292,CSGALNACT2,isa,FPLX,000065,Beta_3_4_GTF
+HGNC,26182,COLGALT1,isa,FPLX,000112,COLGALT
+HGNC,16790,COLGALT2,isa,FPLX,000112,COLGALT
+HGNC,23056,ALG3,isa,FPLX,000028,ALG3_family
+HGNC,15672,ALG9,isa,FPLX,000028,ALG3_family
+HGNC,19358,ALG12,isa,FPLX,000028,ALG3_family
+HGNC,8959,PIGB,isa,FPLX,000028,ALG3_family
+HGNC,18858,PIGM,isa,FPLX,000028,ALG3_family
+HGNC,26031,PIGV,isa,FPLX,000028,ALG3_family
+HGNC,30596,PIGZ,isa,FPLX,000028,ALG3_family
+HGNC,9202,POMT1,isa,FPLX,000028,ALG3_family
+HGNC,19743,POMT2,isa,FPLX,000028,ALG3_family
+HGNC,3515,EXTL1,isa,FPLX,000165,EXT
+HGNC,3516,EXTL2,isa,FPLX,000165,EXT
+HGNC,3518,EXTL3,isa,FPLX,000165,EXT
+HGNC,3512,EXT1,isa,FPLX,000165,EXT
+HGNC,3513,EXT2,isa,FPLX,000165,EXT
+HGNC,4012,FUT1,isa,FPLX,000176,FUT
+HGNC,4013,FUT2,isa,FPLX,000176,FUT
+HGNC,4014,FUT3,isa,FPLX,000176,FUT
+HGNC,4015,FUT4,isa,FPLX,000176,FUT
+HGNC,4016,FUT5,isa,FPLX,000176,FUT
+HGNC,4017,FUT6,isa,FPLX,000176,FUT
+HGNC,4018,FUT7,isa,FPLX,000176,FUT
+HGNC,4019,FUT8,isa,FPLX,000176,FUT
+HGNC,4020,FUT9,isa,FPLX,000176,FUT
+HGNC,19234,FUT10,isa,FPLX,000176,FUT
+HGNC,19233,FUT11,isa,FPLX,000176,FUT
+HGNC,14988,POFUT1,isa,FPLX,000176,FUT
+HGNC,14683,POFUT2,isa,FPLX,000176,FUT
+HGNC,4203,GCNT1,isa,FPLX,000185,GCNT
+HGNC,4204,GCNT2,isa,FPLX,000185,GCNT
+HGNC,4205,GCNT3,isa,FPLX,000185,GCNT
+HGNC,17973,GCNT4,isa,FPLX,000185,GCNT
+HGNC,16099,GCNT7,isa,FPLX,000185,GCNT
+HGNC,15516,XYLT1,isa,FPLX,000185,GCNT
+HGNC,15517,XYLT2,isa,FPLX,000185,GCNT
+HGNC,9723,PYGB,isa,FPLX,000396,PYG
+HGNC,9725,PYGL,isa,FPLX,000396,PYG
+HGNC,9726,PYGM,isa,FPLX,000396,PYG
+HGNC,20266,ALG5,isa,FPLX,000199,GTF_family_2
+HGNC,21727,B3GNTL1,isa,FPLX,000199,GTF_family_2
+HGNC,3005,DPM1,isa,FPLX,000199,GTF_family_2
+HGNC,4818,HAS1,isa,FPLX,000199,GTF_family_2
+HGNC,4819,HAS2,isa,FPLX,000199,GTF_family_2
+HGNC,4820,HAS3,isa,FPLX,000199,GTF_family_2
+HGNC,79,ABO,isa,FPLX,000200,GTF_family_6
+HGNC,30005,A3GALT2,isa,FPLX,000200,GTF_family_6
+HGNC,20460,GBGT1,isa,FPLX,000200,GTF_family_6
+HGNC,23671,GLT6D1,isa,FPLX,000200,GTF_family_6
+HGNC,24870,GLT8D1,isa,FPLX,000201,GTF_family_8
+HGNC,24890,GLT8D2,isa,FPLX,000201,GTF_family_8
+HGNC,27482,GXYLT1,isa,FPLX,000201,GTF_family_8
+HGNC,33383,GXYLT2,isa,FPLX,000201,GTF_family_8
+HGNC,4699,GYG1,isa,FPLX,000201,GTF_family_8
+HGNC,4700,GYG2,isa,FPLX,000201,GTF_family_8
+HGNC,6511,LARGE1,isa,FPLX,000201,GTF_family_8
+HGNC,16522,LARGE2,isa,FPLX,000201,GTF_family_8
+HGNC,13530,RXYLT1,isa,FPLX,000201,GTF_family_8
+HGNC,26639,XXYLT1,isa,FPLX,000201,GTF_family_8
+HGNC,19350,POGLUT2,isa,FPLX,000203,GTF_family_90
+HGNC,28496,POGLUT3,isa,FPLX,000203,GTF_family_90
+HGNC,22954,POGLUT1,isa,FPLX,000203,GTF_family_90
+HGNC,18294,ALG1,isa,FPLX,000027,ALG1_family
+HGNC,33721,ALG1L,isa,FPLX,000027,ALG1_family
+HGNC,37258,ALG1L2,isa,FPLX,000027,ALG1_family
+HGNC,23159,ALG2,isa,FPLX,000027,ALG1_family
+HGNC,32456,ALG11,isa,FPLX,000027,ALG1_family
+HGNC,26483,GLT1D1,isa,FPLX,000027,ALG1_family
+HGNC,20887,GTDC1,isa,FPLX,000027,ALG1_family
+HGNC,4706,GYS1,isa,FPLX,000027,ALG1_family
+HGNC,4707,GYS2,isa,FPLX,000027,ALG1_family
+HGNC,8957,PIGA,isa,FPLX,000027,ALG1_family
+HGNC,7044,MGAT1,isa,FPLX,000287,MGAT
+HGNC,7045,MGAT2,isa,FPLX,000287,MGAT
+HGNC,7046,MGAT3,isa,FPLX,000287,MGAT
+HGNC,7047,MGAT4A,isa,FPLX,000287,MGAT
+HGNC,7048,MGAT4B,isa,FPLX,000287,MGAT
+HGNC,30871,MGAT4C,isa,FPLX,000287,MGAT
+HGNC,43619,MGAT4D,isa,FPLX,000287,MGAT
+HGNC,7049,MGAT5,isa,FPLX,000287,MGAT
+HGNC,24140,MGAT5B,isa,FPLX,000287,MGAT
+HGNC,28526,EOGT,isa,FPLX,000322,OGT_family
+HGNC,8127,OGT,isa,FPLX,000322,OGT_family
+HGNC,19139,POMGNT1,isa,FPLX,000322,OGT_family
+HGNC,25902,POMGNT2,isa,FPLX,000322,OGT_family
+HGNC,21725,GALNTL5,isa,FPLX,000180,GALNT
+HGNC,33844,GALNTL6,isa,FPLX,000180,GALNT
+HGNC,4123,GALNT1,isa,FPLX,000180,GALNT
+HGNC,4124,GALNT2,isa,FPLX,000180,GALNT
+HGNC,4125,GALNT3,isa,FPLX,000180,GALNT
+HGNC,4126,GALNT4,isa,FPLX,000180,GALNT
+HGNC,4127,GALNT5,isa,FPLX,000180,GALNT
+HGNC,4128,GALNT6,isa,FPLX,000180,GALNT
+HGNC,4129,GALNT7,isa,FPLX,000180,GALNT
+HGNC,4130,GALNT8,isa,FPLX,000180,GALNT
+HGNC,4131,GALNT9,isa,FPLX,000180,GALNT
+HGNC,19873,GALNT10,isa,FPLX,000180,GALNT
+HGNC,19875,GALNT11,isa,FPLX,000180,GALNT
+HGNC,19877,GALNT12,isa,FPLX,000180,GALNT
+HGNC,23242,GALNT13,isa,FPLX,000180,GALNT
+HGNC,22946,GALNT14,isa,FPLX,000180,GALNT
+HGNC,21531,GALNT15,isa,FPLX,000180,GALNT
+HGNC,23233,GALNT16,isa,FPLX,000180,GALNT
+HGNC,30488,GALNT18,isa,FPLX,000180,GALNT
+HGNC,16347,GALNT17,isa,FPLX,000180,GALNT
+HGNC,10862,ST3GAL1,isa,FPLX,000202,GTF_family_29
+HGNC,10863,ST3GAL2,isa,FPLX,000202,GTF_family_29
+HGNC,10866,ST3GAL3,isa,FPLX,000202,GTF_family_29
+HGNC,10864,ST3GAL4,isa,FPLX,000202,GTF_family_29
+HGNC,10872,ST3GAL5,isa,FPLX,000202,GTF_family_29
+HGNC,18080,ST3GAL6,isa,FPLX,000202,GTF_family_29
+HGNC,23614,ST6GALNAC1,isa,FPLX,000202,GTF_family_29
+HGNC,10867,ST6GALNAC2,isa,FPLX,000202,GTF_family_29
+HGNC,19343,ST6GALNAC3,isa,FPLX,000202,GTF_family_29
+HGNC,17846,ST6GALNAC4,isa,FPLX,000202,GTF_family_29
+HGNC,19342,ST6GALNAC5,isa,FPLX,000202,GTF_family_29
+HGNC,23364,ST6GALNAC6,isa,FPLX,000202,GTF_family_29
+HGNC,10860,ST6GAL1,isa,FPLX,000202,GTF_family_29
+HGNC,10861,ST6GAL2,isa,FPLX,000202,GTF_family_29
+HGNC,10869,ST8SIA1,isa,FPLX,000202,GTF_family_29
+HGNC,10870,ST8SIA2,isa,FPLX,000202,GTF_family_29
+HGNC,14269,ST8SIA3,isa,FPLX,000202,GTF_family_29
+HGNC,10871,ST8SIA4,isa,FPLX,000202,GTF_family_29
+HGNC,17827,ST8SIA5,isa,FPLX,000202,GTF_family_29
+HGNC,23317,ST8SIA6,isa,FPLX,000202,GTF_family_29
+HGNC,6172,STT3A,isa,FPLX,000455,STT3
+HGNC,30611,STT3B,isa,FPLX,000455,STT3
+HGNC,12524,UGCG,isa,FPLX,000491,UGCG
+HGNC,15663,UGGT1,isa,FPLX,000493,UGGT
+HGNC,15664,UGGT2,isa,FPLX,000493,UGGT
+HGNC,12529,UGT1A,isa,FPLX,000492,UGT
+HGNC,12530,UGT1A1,isa,FPLX,000492,UGT
+HGNC,12534,UGT1A2P,isa,FPLX,000492,UGT
+HGNC,12535,UGT1A3,isa,FPLX,000492,UGT
+HGNC,12536,UGT1A4,isa,FPLX,000492,UGT
+HGNC,12537,UGT1A5,isa,FPLX,000492,UGT
+HGNC,12538,UGT1A6,isa,FPLX,000492,UGT
+HGNC,12539,UGT1A7,isa,FPLX,000492,UGT
+HGNC,12540,UGT1A8,isa,FPLX,000492,UGT
+HGNC,12541,UGT1A9,isa,FPLX,000492,UGT
+HGNC,12531,UGT1A10,isa,FPLX,000492,UGT
+HGNC,12532,UGT1A11P,isa,FPLX,000492,UGT
+HGNC,12533,UGT1A12P,isa,FPLX,000492,UGT
+HGNC,32191,UGT1A13P,isa,FPLX,000492,UGT
+HGNC,12542,UGT2A1,isa,FPLX,000492,UGT
+HGNC,28183,UGT2A2,isa,FPLX,000492,UGT
+HGNC,28528,UGT2A3,isa,FPLX,000492,UGT
+HGNC,12553,UGT2B4,isa,FPLX,000492,UGT
+HGNC,12554,UGT2B7,isa,FPLX,000492,UGT
+HGNC,12544,UGT2B10,isa,FPLX,000492,UGT
+HGNC,12545,UGT2B11,isa,FPLX,000492,UGT
+HGNC,12546,UGT2B15,isa,FPLX,000492,UGT
+HGNC,12547,UGT2B17,isa,FPLX,000492,UGT
+HGNC,12548,UGT2B24P,isa,FPLX,000492,UGT
+HGNC,12549,UGT2B25P,isa,FPLX,000492,UGT
+HGNC,12550,UGT2B26P,isa,FPLX,000492,UGT
+HGNC,12551,UGT2B27P,isa,FPLX,000492,UGT
+HGNC,13479,UGT2B28,isa,FPLX,000492,UGT
+HGNC,12552,UGT2B29P,isa,FPLX,000492,UGT
+HGNC,26625,UGT3A1,isa,FPLX,000492,UGT
+HGNC,27266,UGT3A2,isa,FPLX,000492,UGT
+HGNC,12555,UGT8,isa,FPLX,000492,UGT
+HGNC,30881,ALG13,isa,FPLX,000030,ALG13_family
+HGNC,28287,ALG14,isa,FPLX,000030,ALG13_family
+HGNC,9855,RAP1A,isa,FPLX,000401,RAP1
+HGNC,9857,RAP1B,isa,FPLX,000401,RAP1
+HGNC,11142,SIK1,isa,FPLX,000433,SIK
+HGNC,21680,SIK2,isa,FPLX,000433,SIK
+HGNC,29165,SIK3,isa,FPLX,000433,SIK
+HGNC,3091,DYRK1A,isa,FPLX,000146,DYRK
+HGNC,3092,DYRK1B,isa,FPLX,000146,DYRK
+HGNC,3093,DYRK2,isa,FPLX,000146,DYRK
+HGNC,3094,DYRK3,isa,FPLX,000146,DYRK
+HGNC,3095,DYRK4,isa,FPLX,000146,DYRK
+HGNC,25174,HAUS1,partof,FPLX,000061,Augmin
+HGNC,25530,HAUS2,partof,FPLX,000061,Augmin
+HGNC,28719,HAUS3,partof,FPLX,000061,Augmin
+HGNC,20163,HAUS4,partof,FPLX,000061,Augmin
+HGNC,29130,HAUS5,partof,FPLX,000061,Augmin
+HGNC,25948,HAUS6,partof,FPLX,000061,Augmin
+HGNC,32979,HAUS7,partof,FPLX,000061,Augmin
+HGNC,30532,HAUS8,partof,FPLX,000061,Augmin
+HGNC,16062,CRTC1,isa,FPLX,000123,CRTC
+HGNC,27301,CRTC2,isa,FPLX,000123,CRTC
+HGNC,26148,CRTC3,isa,FPLX,000123,CRTC
diff --git a/grounding_map.csv b/grounding_map.csv
index 5e87c69f4..ecc3bed05 100644
--- a/grounding_map.csv
+++ b/grounding_map.csv
@@ -529,8 +529,9 @@ cell adhesion,GO,GO:0007155,MESH,D002448,,
 cell cycle,GO,GO:0007049,MESH,D002453,,
 cell death,GO,GO:0008219,MESH,D016923,,
 cell growth,GO,GO:0016049,MESH,D048708,,
-cell migration,GO,GO:0016477,MESH,D002465,,
+cell migration,GO,GO:0016477,MESH,D002465,NCIT,C26169
 cell motility,GO,GO:0016477,MESH,D002465,,
+cell motility,NCIT,C16404,GO,GO:0048870,,
 cell proliferation,GO,GO:0008283,MESH,D049109,,
 cell survival,MESH,D002470,,,,
 cell viability,MESH,D002470,,,,
@@ -1732,7 +1733,6 @@ PBXs,FPLX,PBX,,,,
 Pca,MESH,D011471,,,,
 PCNA,UP,P12004,,,,
 PD,MESH,D010300,,,,
-PD-1,HGNC,PDCD1,,,,
 PD98509,CHEBI,CHEBI:79091,,,,
 PDE 2,HGNC,PDE2A,,,,
 PDE 3,FPLX,PDE3,,,,
@@ -2549,8 +2549,6 @@ eGFR,MESH,D005919,,,,
 CDK1/2,FPLX,CDK1_2,,,,
 cdk1/2,FPLX,CDK1_2,,,,
 Cdk1/2,FPLX,CDK1_2,,,,
-cell migration,MESH,D002465,NCIT,C26169,GO,GO:0016477
-cell motility,MESH,D002465,NCIT,C16404,GO,GO:0048870
 Chk1/2,FPLX,CHEK,,,,
 chromosomal instability,MESH,D043171,NCIT,C48195,,
 chromosomal instabiliy,MESH,D043171,NCIT,C48195,,
diff --git a/import/bel_grounding_map.py b/import/bel_grounding_map.py
index ba97de918..6083d2d87 100644
--- a/import/bel_grounding_map.py
+++ b/import/bel_grounding_map.py
@@ -1,6 +1,7 @@
-from common import *
+from common import load_entity_list, load_equivalences, load_grounding_map
 
-if __name__ == '__main__':
+
+def main():
     equivalences = load_equivalences('../equivalences.csv')
     has_bel_mapping = set()
     for source_db, source_id, be_id in equivalences:
@@ -40,3 +41,7 @@
 
     bel_to_lookup = sorted(bel_counts.items(), key=lambda x: x[1], reverse=True)
     bel_to_lookup = [b for b in bel_to_lookup if b[1] > 0]
+
+
+if __name__ == '__main__':
+    main()
diff --git a/import/common.py b/import/common.py
index 273ef29b4..e0ce6e0cd 100644
--- a/import/common.py
+++ b/import/common.py
@@ -1,13 +1,11 @@
-import re
-import sys
 import csv
-from indra.statements import Agent
+import sys
+
 from indra.databases import hgnc_client
-from indra.databases import uniprot_client
-from indra.tools.expand_families import Expander
 from indra.preassembler.hierarchy_manager import hierarchies
+from indra.statements import Agent
+from indra.tools.expand_families import Expander
 
-import common
 
 def read_csv(fh, delimiter, quotechar):
     if sys.version_info.major < 3:
@@ -63,7 +61,7 @@ def load_entity_list(filename):
 
 def get_child_map():
     """Get dictionary mapping FPLX IDs to Uniprot IDs of all children."""
-    entities = common.load_entity_list('../entities.csv')
+    entities = load_entity_list('../entities.csv')
 
     be_agents = [Agent(be_id, db_refs={'FPLX': be_id})
                  for be_id in entities]
diff --git a/import/greek_letter_mappings.py b/import/greek_letter_mappings.py
index 4c29d9e03..817d2dcdd 100644
--- a/import/greek_letter_mappings.py
+++ b/import/greek_letter_mappings.py
@@ -4,15 +4,17 @@
 character, and add en entry to the grounding map for each of these
 if they aren't already in there"""
 
-import os
 import csv
+import os
+
 from indra.resources.greek_alphabet import greek_alphabet
 
 # These are the characters that are spelled out and we want to map
 chars_to_map = ['alpha', 'beta', 'gamma', 'delta', 'epsilon', 'kappa', 'theta']
 greek_reverse = {v: k for k, v in greek_alphabet.items()}
 
-if __name__ == '__main__':
+
+def main():
     path_this = os.path.dirname(os.path.abspath(__file__))
     gm_file = os.path.join(path_this, os.pardir, 'grounding_map.csv')
     new_rows = []
@@ -53,3 +55,5 @@
             csvwriter.writerow(row)
 
 
+if __name__ == '__main__':
+    main()
diff --git a/import/interpro_mappings.py b/import/interpro_mappings.py
index 3e32c0f67..a2ed9d8a2 100644
--- a/import/interpro_mappings.py
+++ b/import/interpro_mappings.py
@@ -1,19 +1,19 @@
 import json
+import os
 from collections import defaultdict
-from indra.statements import Agent
-from indra.databases import hgnc_client
-from indra.tools.expand_families import Expander
-from indra.preassembler.hierarchy_manager import hierarchies
+
+from common import get_child_map, jaccard_index, read_csv
 from indra.databases import uniprot_client
 
-import common
 
 def get_ip_families_for_be(be_up_ids, cache_file=None):
-    if cache_file is not None:
+    if cache_file is not None and os.path.exists(cache_file):
         with open(cache_file, 'rt') as f:
             ipfs = [line.strip() for line in f.readlines()]
         return ipfs
+
     # If not cached, read from file
+    ip_families_for_be = set()
     with open('protein2ipr.dat', 'rt') as f:
         counter = 0
         while True:
@@ -29,9 +29,14 @@ def get_ip_families_for_be(be_up_ids, cache_file=None):
                 ip_families_for_be.add(ip_id)
             counter += 1
 
+    return ip_families_for_be
+
 
-def get_ip_family_members(ip_families_for_be, ip_datafile='protein2ipr.dat',
-                          cache_file=None):
+def get_ip_family_members(
+        ip_families_for_be,
+        ip_datafile='protein2ipr.dat',
+        cache_file=None,
+):
     # Check if Interpro info is cached
     if cache_file is not None:
         with open(cache_file, 'rt') as f:
@@ -51,8 +56,10 @@ def get_ip_family_members(ip_families_for_be, ip_datafile='protein2ipr.dat',
             if ip_id in ip_families_for_be and uniprot_client.is_human(up_id):
                 ip_fam_info = ip_family_members.get(ip_id)
                 if ip_fam_info is None:
-                    ip_family_members[ip_id] = {'name': ip_name,
-                                                'members': [up_id]}
+                    ip_family_members[ip_id] = {
+                        'name': ip_name,
+                        'members': [up_id]
+                    }
                 else:
                     ip_fam_info['members'].append(up_id)
             counter += 1
@@ -63,7 +70,7 @@ def get_ip_family_members(ip_families_for_be, ip_datafile='protein2ipr.dat',
 
 def load_uniprot(filename):
     with open(filename, 'rt') as f:
-        entries = common.read_csv(f, delimiter='\t', quotechar='"')
+        entries = read_csv(f, delimiter='\t', quotechar='"')
     up_ids = [row[0] for row in entries[1:]]
     return up_ids
 
@@ -85,31 +92,44 @@ def get_mappings(be_child_map, ip_family_members, uniprot_ids,
             # Skip empty sets
             if not ip_set:
                 continue
-            jacc = common.jaccard_index(be_set, ip_set)
+            jacc = jaccard_index(be_set, ip_set)
             if jacc >= jaccard_cutoff:
-                mapping = {'id': ip_id, 'name': ip_name,
-                           'members': list(ip_set), 'jaccardIndex': jacc,
-                           'equivalence': 'IP,%s,%s' % (ip_id, be_id)}
+                mapping = {
+                    'id': ip_id, 'name': ip_name,
+                    'members': list(ip_set), 'jaccardIndex': jacc,
+                    'equivalence': 'IP,%s,%s' % (ip_id, be_id)
+                }
                 mappings[be_id].append(mapping)
         if be_id in mappings:
             mappings[be_id].sort(key=lambda d: d['jaccardIndex'], reverse=True)
     return mappings
 
 
-if __name__ == '__main__':
-    be_child_map = common.get_child_map()
+def main():
+    be_child_map = get_child_map()
     be_up_ids = [up_id for child_list in be_child_map.values()
-                       for up_id in child_list]
+                 for up_id in child_list]
 
-    ip_families_for_be = get_ip_families_for_be(be_up_ids,
-                                    cache_file='ip_families_for_be.txt')
-    ip_family_members = get_ip_family_members(ip_families_for_be,
-                                        cache_file='ip_family_members.json')
+    ip_families_for_be = get_ip_families_for_be(
+        be_up_ids,
+        cache_file='ip_families_for_be.txt',
+    )
+    ip_family_members = get_ip_family_members(
+        ip_families_for_be,
+        cache_file='ip_family_members.json',
+    )
     up_ids = load_uniprot('uniprot_reviewed_human.tsv')
-    mappings = get_mappings(be_child_map, ip_family_members, up_ids,
-                            jaccard_cutoff=1)
+    mappings = get_mappings(
+        be_child_map,
+        ip_family_members,
+        up_ids,
+        jaccard_cutoff=1,
+    )
     for be_id, map_list in mappings.items():
         for map_info in map_list:
             ip_id = map_info['id']
             print("IP,%s,%s" % (ip_id, be_id))
 
+
+if __name__ == '__main__':
+    main()
diff --git a/import/reactome_mappings.py b/import/reactome_mappings.py
index 770368c44..569c588a6 100644
--- a/import/reactome_mappings.py
+++ b/import/reactome_mappings.py
@@ -1,23 +1,24 @@
-import csv
 import json
-import requests
-from functools import lru_cache
+import os
 from collections import defaultdict
+from functools import lru_cache
+
+import requests
 
-import common
+from common import get_child_map, jaccard_index
 
 
 @lru_cache(10000)
 def rx_id_from_up_id(up_id):
     """Get the Reactome Stable ID for a given Uniprot ID."""
     react_search_url = 'http://www.reactome.org/ContentService/search/query'
-    params = {'query': up_id, 'cluster': 'true', 'species':'Homo sapiens'}
+    params = {'query': up_id, 'cluster': 'true', 'species': 'Homo sapiens'}
     headers = {'Accept': 'application/json'}
     res = requests.get(react_search_url, headers=headers, params=params)
     if not res.status_code == 200:
         return None
-    json = res.json()
-    results = json.get('results')
+    res_json = res.json()
+    results = res_json.get('results')
     if not results:
         print('No results for %s' % up_id)
         return None
@@ -53,16 +54,16 @@ def up_id_from_rx_id(reactome_id):
 
 @lru_cache(10000)
 def get_participants(reactome_id):
-    """Get Uniprot IDs of members of a Reactome DefinedSet or CandidateSet."""
+    """Get UniProt IDs of members of a Reactome DefinedSet or CandidateSet."""
     react_url = 'http://www.reactome.org/ContentService/data/event/' \
                 + reactome_id + '/participatingReferenceEntities'
     headers = {'Accept': 'application/json'}
     res = requests.get(react_url, headers=headers)
     if not res.status_code == 200:
         return []
-    json = res.json()
+    res_json = res.json()
     up_ids = []
-    for res in json:
+    for res in res_json:
         if not res.get('databaseName') == 'UniProt':
             continue
         up_id = res.get('identifier')
@@ -73,16 +74,16 @@ def get_participants(reactome_id):
 
 @lru_cache(10000)
 def get_subunits(complex_id):
-    """Get Uniprot IDs of subunits of a Reactome Complex."""
+    """Get UniProt IDs of subunits of a Reactome Complex."""
     react_url = 'http://www.reactome.org/ContentService/data/complex/' \
                 + complex_id + '/subunits'
     headers = {'Accept': 'application/json'}
     res = requests.get(react_url, headers=headers)
     if not res.status_code == 200:
         return []
-    json = res.json()
+    res_json = res.json()
     up_ids = []
-    for subunit in json:
+    for subunit in res_json:
         subunit_rx_id = subunit.get('stId')
         if not subunit_rx_id:
             continue
@@ -94,20 +95,19 @@ def get_subunits(complex_id):
 
 @lru_cache(10000)
 def _get_parents(stable_id):
-    """Recursively get all parents of a Reactome ID."""
+    """Get all parents of a Reactome ID recursively."""
     react_data_url = 'http://www.reactome.org/ContentService/data/entity/' + \
                      stable_id + '/componentOf'
     headers = {'Accept': 'application/json'}
     res = requests.get(react_data_url, headers=headers)
     if not res.status_code == 200:
         return []
-    json = res.json()
+    res_json = res.json()
     names = []
     stable_ids = []
     schema_classes = []
-    for parent_group in json:
-        if not parent_group.get('type') in \
-                            ['hasComponent', 'hasMember', 'hasCandidate']:
+    for parent_group in res_json:
+        if not parent_group.get('type') in ['hasComponent', 'hasMember', 'hasCandidate']:
             continue
         names += parent_group.get('names')
         stable_ids += parent_group.get('stIds')
@@ -121,10 +121,10 @@ def _get_parents(stable_id):
 
 @lru_cache(10000)
 def get_all_parents(up_id):
-    """Get all parents for all Reactome IDs linked to a Uniprot ID."""
+    """Get all parents for all Reactome IDs linked to a UniProt ID."""
     linked_stable_ids = rx_id_from_up_id(up_id)
     if linked_stable_ids is None:
-        return ([], [])
+        return [], []
     parents = []
     for ls_id in linked_stable_ids:
         parents += _get_parents(ls_id)
@@ -133,22 +133,22 @@ def get_all_parents(up_id):
     return sets, complexes
 
 
-def get_rx_family_members(up_ids, cache_file=None):
-    """Get dictionary mapping Reactome sets/complexes to member Uniprot IDs."""
+def get_rx_family_members(fplx_id_to_children, cache_file=None):
+    """Get dictionary mapping Reactome sets/complexes to member UniProt IDs."""
     # Check to see if we're loading from a cache
-    if cache_file is not None:
+    if cache_file is not None and os.path.exists(cache_file):
         with open(cache_file, 'rt') as f:
             rx_family_members = json.load(f)
         return rx_family_members
 
     # Not cached, get members from the Reactome web service
     rx_family_members = {}
-    for be_id, children_up_ids in be_child_map.items():
-        print("Getting family info for %s" % be_id)
+    for fplx_id, up_ids in fplx_id_to_children.items():
+        print("Getting family info for FPLX:%s" % fplx_id)
         # For every child, get all parents in Reactome
         rx_sets = set([])
         rx_complexes = set([])
-        for up_id in children_up_ids:
+        for up_id in up_ids:
             sets, complexes = get_all_parents(up_id)
             rx_sets = rx_sets.union(sets)
             rx_complexes = rx_complexes.union(complexes)
@@ -169,8 +169,10 @@ def get_rx_family_members(up_ids, cache_file=None):
                       (rx_type, name, rx_id))
                 continue
             # Save info in dict
-            rx_family_members[rx_id] = {'name': name, 'type': rx_type,
-                                        'members': list(rx_members)}
+            rx_family_members[rx_id] = {
+                'name': name, 'type': rx_type,
+                'members': list(rx_members)
+            }
     # Save to JSON
     with open('rx_family_members.json', 'wt') as f:
         json.dump(rx_family_members, f, indent=2)
@@ -178,13 +180,14 @@ def get_rx_family_members(up_ids, cache_file=None):
     return rx_family_members
 
 
-def get_mappings(be_child_map, rx_family_members, jaccard_cutoff=1.):
+def get_mappings(fplx_id_to_children, rx_family_members, jaccard_cutoff=1.):
     """Find matches between FPLX and Reactome families/complexes."""
     mappings = defaultdict(list)
-    for be_id, be_children in be_child_map.items():
+
+    for fplx_id, up_ids in fplx_id_to_children.items():
         # Skip empty sets
-        be_set = set(be_children)
-        if not be_set:
+        up_ids = set(up_ids)
+        if not up_ids:
             continue
         for rx_id, rx_info in rx_family_members.items():
             rx_name = rx_info['name']
@@ -193,24 +196,32 @@ def get_mappings(be_child_map, rx_family_members, jaccard_cutoff=1.):
             # Skip empty sets
             if not rx_set:
                 continue
-            jacc = common.jaccard_index(be_set, rx_set)
+            jacc = jaccard_index(up_ids, rx_set)
             if jacc >= jaccard_cutoff:
-                mapping = {'reactomeId': rx_id, 'reactomeType': rx_type,
-                           'reactomeName': rx_name,
-                           'reactomeMembers': list(rx_set),
-                           'jaccardIndex': jacc}
-                mappings[be_id].append(mapping)
-        if be_id in mappings:
-            mappings[be_id].sort(key=lambda d: d['jaccardIndex'], reverse=True)
-    return mappings
+                mappings[fplx_id].append({
+                    'reactomeId': rx_id,
+                    'reactomeType': rx_type,
+                    'reactomeName': rx_name,
+                    'reactomeMembers': list(rx_set),
+                    'jaccardIndex': jacc,
+                })
+
+        if fplx_id in mappings:
+            mappings[fplx_id].sort(key=lambda d: d['jaccardIndex'], reverse=True)
+
+    return dict(mappings)
+
+
+def main():
+    fplx_child_map = get_child_map()
+    rx_family_members = get_rx_family_members(
+        fplx_child_map,
+        cache_file='rx_family_members.json',
+    )
+    mappings = get_mappings(fplx_child_map, rx_family_members, jaccard_cutoff=1.)
+    with open('reactome_mappings.json', 'wt') as f:
+        json.dump(mappings, f, indent=2)
 
 
 if __name__ == '__main__':
-    be_child_map = common.get_child_map()
-    be_up_ids = [up_id for child_list in be_child_map.values()
-                       for up_id in child_list]
-    rx_family_members = get_rx_family_members(be_up_ids,
-                                          cache_file='rx_family_members.json')
-    mappings = get_mappings(be_child_map, rx_family_members, jaccard_cutoff=1.)
-    with open('reactome_mappings.json', 'wt') as f:
-        json.dump(mappings, f, indent=2)
+    main()
diff --git a/import/signor_mappings.py b/import/signor_mappings.py
index 3856d29e3..133faa3d6 100644
--- a/import/signor_mappings.py
+++ b/import/signor_mappings.py
@@ -1,14 +1,16 @@
 """Propose mappings between FamPlex and Signor families based on members."""
+
 import csv
-from collections import namedtuple, defaultdict
-import common
+from collections import defaultdict
+
+from common import get_child_map, jaccard_index
 
 
 def get_signor_pf_map(pf_filename):
     signor_pf = {}
     with open(pf_filename, 'rt') as f:
         csvreader = csv.reader(f, delimiter=';')
-        next(csvreader) # Skip header row
+        next(csvreader)  # Skip header row
         for row in csvreader:
             pf_id, pf_name, pf_member_list = row
             up_ids = [s.strip() for s in pf_member_list.split(',')]
@@ -29,26 +31,31 @@ def get_mappings(fplx_child_map, signor_pf_map, jaccard_cutoff=1.):
             fplx_set = set(fplx_children)
             if not fplx_set:
                 continue
-            jacc = common.jaccard_index(fplx_set, signor_set)
+            jacc = jaccard_index(fplx_set, signor_set)
             if jacc >= jaccard_cutoff:
-                mapping = {'signorId': signor_id,
-                           'signorName': signor_name,
-                           'signorMembers': list(signor_set),
-                           'fplxId': fplx_id,
-                           'fplxMembers': list(fplx_set),
-                           'eqEntry': 'SIGNOR,%s,%s' % (signor_id, fplx_id),
-                           'jaccardIndex': jacc}
-                mappings[signor_id].append(mapping)
+                mappings[signor_id].append({
+                    'signorId': signor_id,
+                    'signorName': signor_name,
+                    'signorMembers': list(signor_set),
+                    'fplxId': fplx_id,
+                    'fplxMembers': list(fplx_set),
+                    'eqEntry': 'SIGNOR,%s,%s' % (signor_id, fplx_id),
+                    'jaccardIndex': jacc,
+                })
+
         if signor_id in mappings:
-            mappings[signor_id].sort(key=lambda d: d['jaccardIndex'],
-                                     reverse=True)
-    return mappings
+            mappings[signor_id].sort(key=lambda d: d['jaccardIndex'], reverse=True)
 
+    return dict(mappings)
 
-if __name__ == '__main__':
-    fplx_child_map = common.get_child_map()
+
+def main():
+    fplx_child_map = get_child_map()
     signor_pf_map = get_signor_pf_map('SIGNOR_PF.csv')
     mappings = get_mappings(fplx_child_map, signor_pf_map, jaccard_cutoff=1.)
     for k, v in mappings.items():
         print(v[0]['eqEntry'])
 
+
+if __name__ == '__main__':
+    main()