diff --git a/.gitignore b/.gitignore
index e43b0f9..6a4dae1 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1 +1,2 @@
 .DS_Store
+__pycache__
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..8b1959c
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,42 @@
+[build-system]
+requires = ["setuptools>=45", "wheel"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "MARS"
+version = "1.0.0"
+description = "MARS: Meta-learning approach for cell type discovery in heterogeneous single-cell data"
+readme = "README.md"
+requires-python = "== 3.8.*"
+license = {text = "MIT"}
+authors = [
+    {name = "Maria Brbic", email = "mbrbic@cs.stanford.edu"},
+]
+keywords = ["single-cell", "machine-learning", "meta-learning", "bioinformatics", "pytorch"]
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "Intended Audience :: Science/Research", 
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3.8",
+    "Topic :: Scientific/Engineering :: Artificial Intelligence",
+    "Topic :: Scientific/Engineering :: Bio-Informatics",
+]
+dependencies = [
+    "Cython == 0.29.14",
+    "anndata == 0.8.0",
+    "matplotlib < 3.7",
+    "numpy >= 1.8.2, < 1.20",
+    "pandas >= 0.25.0, < 2",
+    "scanpy >= 1.4.4, < 1.6",
+    "scikit-learn >= 0.19.2, < 0.24",
+    "scipy >= 1.3.1",
+    "torch >= 1.2.0",
+]
+
+[project.urls]
+Homepage = "http://snap.stanford.edu/mars"
+Repository = "https://github.com/snap-stanford/mars"
+Documentation = "https://github.com/snap-stanford/mars/blob/master/README.md"
+
+[tool.setuptools]
+packages = ["data", "model"]
diff --git a/requirements.txt b/requirements.txt
deleted file mode 100644
index d298593..0000000
--- a/requirements.txt
+++ /dev/null
@@ -1,125 +0,0 @@
-absl-py==0.8.1
-anndata==0.6.22.post1
-annoy==1.16.0
-appnope==0.1.0
-astor==0.8.0
-attrs==19.1.0
-backcall==0.1.0
-bleach==3.1.0
-CacheControl==0.12.5
-cachetools==3.1.1
-certifi==2019.6.16
-chardet==3.0.4
-coverage==4.5.4
-cycler==0.10.0
-Cython==0.29.14
-decorator==4.4.0
-defusedxml==0.6.0
-docopt==0.6.2
-entrypoints==0.3
-fbpca==1.0
-future==0.17.1
-gast==0.2.2
-goatools==0.9.9
-google-auth==1.6.3
-google-auth-oauthlib==0.4.1
-google-pasta==0.1.7
-grpcio==1.24.3
-h5py==2.9.0
-hdmedians==0.13
-hyperopt==0.1.2
-idna==2.8
-importlib-metadata==0.19
-ipykernel==5.1.2
-ipython==7.7.0
-ipython-genutils==0.2.0
-ipywidgets==7.5.1
-jedi==0.14.1
-Jinja2==2.10.1
-joblib==0.13.2
-jsonschema==3.0.2
-kiwisolver==1.1.0
-kopt==0.1.0
-leidenalg==0.7.0
-llvmlite==0.29.0
-lockfile==0.12.2
-loompy==2.0.17
-Markdown==3.1.1
-MarkupSafe==1.1.1
-matplotlib==3.0.3
-mistune==0.8.4
-mock==3.0.5
-more-itertools==8.0.0
-msgpack==0.6.2
-natsort==6.0.0
-nbconvert==5.6.0
-nbformat==4.4.0
-networkx==2.3
-nose==1.3.7
-notebook==6.0.0
-numba==0.45.0
-numexpr==2.6.9
-numpy==1.17.0
-oauthlib==3.1.0
-opt-einsum==3.1.0
-packaging==19.2
-pandas==0.25.0
-pandocfilters==1.4.2
-parso==0.5.1
-patsy==0.5.1
-pexpect==4.7.0
-pickleshare==0.7.5
-pluggy==0.13.1
-prometheus-client==0.7.1
-prompt-toolkit==2.0.9
-protobuf==3.10.0
-ptyprocess==0.6.0
-py==1.8.0
-pyasn1==0.4.7
-pyasn1-modules==0.2.7
-pydot==1.4.1
-Pygments==2.4.2
-pymongo==3.8.0
-pyparsing==2.4.2
-pyrsistent==0.15.4
-pytest==5.3.1
-pytest-cov==2.8.1
-python-dateutil==2.8.0
-python-igraph==0.7.1.post6
-pytz==2019.2
-PyYAML==5.2
-pyzmq==18.1.0
-qtconsole==4.5.2
-requests==2.22.0
-requests-oauthlib==1.2.0
-rsa==4.0
-scanpy==1.4.4.post1
-scikit-bio==0.5.5
-scikit-learn==0.19.2
-scipy==1.3.1
-scvi==0.4.1
-seaborn==0.9.0
-Send2Trash==1.5.0
-six==1.12.0
-statsmodels==0.10.1
-tables==3.5.2
-tb-nightly==1.14.0a20190301
-termcolor==1.1.0
-terminado==0.8.2
-testpath==0.4.2
-tf-estimator-nightly==1.14.0.dev2019030115
-torch==1.2.0
-tornado==6.0.3
-tqdm==4.33.0
-traitlets==4.3.2
-umap-learn==0.3.9
-urllib3==1.25.6
-wcwidth==0.1.7
-webencodings==0.5.1
-Werkzeug==0.16.0
-wget==3.2
-widgetsnbextension==3.5.1
-wrapt==1.11.2
-xlrd==1.2.0
-XlsxWriter==1.2.6
-zipp==0.5.2