diff --git a/requirements.txt b/requirements.txt
index d298593..08619b7 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -92,7 +92,7 @@ pyzmq==18.1.0
 qtconsole==4.5.2
 requests==2.22.0
 requests-oauthlib==1.2.0
-rsa==4.0
+rsa==4.1
 scanpy==1.4.4.post1
 scikit-bio==0.5.5
 scikit-learn==0.19.2