Adding more signaling pathways to PROGENy

[FFriis]

Dear authors of PROGENy,

Thank you for a great resource.
I am working specifically with mTOR signaling and have a great interest in finding ways to determine signaling enrichment in this pathway, other than using gene ontology etc. for scRNA-seq workflows.
Therefore my question is whether you intend to add other signaling pathways to the progeny database in the near future?

Best regards
Frederik Sørensen
University of Copenhagen

[deeenes]

Dear Frederik,

It would be great to add new pathways, and indeed mTOR/autophagy is a pathway that we were thinking about already. To do that, we need transcriptomics from a set of perturbation experiments specific for this pathway, in order to establish a signature (footprint). The biological precondition of this is that the process must have a transcriptomics signature: we're at this point atm, trying to find out if autophagy has such a signature. Some colleagues are working on this, if you want to contact them, please write us at omnipathdb@gmail.com.

Best,

Denes