From b14c3195750af3b9636c2fb29b6095893471c022 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 20 Apr 2024 11:35:31 +0200 Subject: [PATCH 01/57] Increment version number to 2.0.3.9000 --- DESCRIPTION | 2 +- NEWS.md | 2 ++ 2 files changed, 3 insertions(+), 1 deletion(-) diff --git a/DESCRIPTION b/DESCRIPTION index d2912ec..4ffb058 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,6 +1,6 @@ Package: dbparser Title: Drugs Databases Parser -Version: 2.0.3 +Version: 2.0.3.9000 Authors@R: c( person("Mohammed", "Ali", email = "moh_fcis@yahoo.com", role = c("aut", "cre")), diff --git a/NEWS.md b/NEWS.md index 89f0cfe..700c5cb 100644 --- a/NEWS.md +++ b/NEWS.md @@ -1,3 +1,5 @@ +# dbparser (development version) + # dbparser 2.0.3 ## Enhancements From d1ba888f9157bf9fcb8c4acd38907fc828e575e8 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Tue, 16 Sep 2025 18:50:53 +0300 Subject: [PATCH 02/57] #177, updated package version --- DESCRIPTION | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/DESCRIPTION b/DESCRIPTION index 4ffb058..a4fca28 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,6 +1,6 @@ Package: dbparser Title: Drugs Databases Parser -Version: 2.0.3.9000 +Version: 2.1.0.9000 Authors@R: c( person("Mohammed", "Ali", email = "moh_fcis@yahoo.com", role = c("aut", "cre")), From 5b7c94574fec4debd1746d7770e945da5ba9932d Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 28 Sep 2025 15:30:09 +0300 Subject: [PATCH 03/57] #177,added data.table dependency and exported new parser --- DESCRIPTION | 3 ++- NAMESPACE | 2 ++ 2 files changed, 4 insertions(+), 1 deletion(-) diff --git a/DESCRIPTION b/DESCRIPTION index a4fca28..d47aaf2 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -12,13 +12,14 @@ Description: This tool is for parsing public drug databases such as 'DrugBank' X License: MIT + file LICENSE Encoding: UTF-8 Imports: + data.table, dplyr, progress, purrr, tibble, tools, XML -RoxygenNote: 7.2.3 +RoxygenNote: 7.3.3 Suggests: canvasXpress, knitr, diff --git a/NAMESPACE b/NAMESPACE index 2fa538f..ae1807f 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -3,6 +3,7 @@ export(cett_nodes_options) export(drug_node_options) export(parseDrugBank) +export(parseOnSIDES) export(references_node_options) export(show_dvobject_metadata) import(dplyr) @@ -16,6 +17,7 @@ importFrom(XML,xmlSize) importFrom(XML,xmlToDataFrame) importFrom(XML,xmlToList) importFrom(XML,xmlValue) +importFrom(data.table,fread) importFrom(progress,progress_bar) importFrom(purrr,'%>%') importFrom(purrr,is_empty) From 6a7ca57d11625f02ee5591b4601a328a6ee7c34c Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 28 Sep 2025 15:30:45 +0300 Subject: [PATCH 04/57] #177, added new onside parser --- R/onsides_parser.R | 59 +++++++++++++++++++++++++++++++++++++++++++++ man/dbparser.Rd | 2 +- man/parseOnSIDES.Rd | 23 ++++++++++++++++++ 3 files changed, 83 insertions(+), 1 deletion(-) create mode 100644 R/onsides_parser.R create mode 100644 man/parseOnSIDES.Rd diff --git a/R/onsides_parser.R b/R/onsides_parser.R new file mode 100644 index 0000000..1e92535 --- /dev/null +++ b/R/onsides_parser.R @@ -0,0 +1,59 @@ + +#' Parse the OnSIDES Core Relational Database +#' +#' Parses the core relational tables from the OnSIDES database. +#' +#' @param dataDir A string specifying the path to the directory containing the +#' OnSIDES CSV files. +#' @param include_high_confidence Logical. If TRUE (the default), the function +#' will also parse the `high_confidence.csv` file, which is a pre-aggregated +#' summary of ingredient-to-effect relationships. If the file is not found, +#' a warning is issued. +#' +#' @return A list of 7 or 8 data.frames. +#' +#' @export +#' @importFrom data.table fread +parseOnSIDES <- function(dataDir, include_high_confidence = TRUE) { + # The 7 canonical files + core_files <- c( + "product_label.csv", + "product_adverse_effect.csv", + "product_to_rxnorm.csv", + "vocab_meddra_adverse_effect.csv", + "vocab_rxnorm_ingredient.csv", + "vocab_rxnorm_product.csv", + "vocab_rxnorm_ingredient_to_product.csv" + ) + + file_paths <- file.path(dataDir, core_files) + names(file_paths) <- gsub("\\.csv$", "", core_files) + + if (!all(file.exists(file_paths))) { + missing <- core_files[!file.exists(file_paths)] + stop("Core files not found in '", dataDir, "':\n", paste(missing, collapse = "\n")) + } + + message("Parsing the 7 core OnSIDES database tables...") + db_tables <- lapply(names(file_paths), function(name) { + message("Reading ", name, ".csv ...") + data.table::fread(file_paths[[name]]) + }) + names(db_tables) <- names(file_paths) + + # --- Optional Handling of high_confidence.csv --- + if (include_high_confidence) { + hc_path <- file.path(dataDir, "high_confidence.csv") + if (file.exists(hc_path)) { + message("Reading high_confidence.csv ...") + hc_table <- data.table::fread(hc_path) + db_tables$high_confidence <- hc_table + } else { + warning("`include_high_confidence` was TRUE, but 'high_confidence.csv' was not found.") + } + } + + message("Successfully parsed OnSIDES database.") + class(db_tables) <- c("OnSIDESDb", "list") + db_tables +} diff --git a/man/dbparser.Rd b/man/dbparser.Rd index a2adf48..11a2d5c 100644 --- a/man/dbparser.Rd +++ b/man/dbparser.Rd @@ -2,8 +2,8 @@ % Please edit documentation in R/dbparser-package.R \docType{package} \name{dbparser} -\alias{dbparser} \alias{dbparser-package} +\alias{dbparser} \title{dbparser: A package for reading and parsing \strong{DrugBank} xml database.} \description{ The main purpose of the `dbparser` package is to parse diff --git a/man/parseOnSIDES.Rd b/man/parseOnSIDES.Rd new file mode 100644 index 0000000..d850084 --- /dev/null +++ b/man/parseOnSIDES.Rd @@ -0,0 +1,23 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/onsides_parser.R +\name{parseOnSIDES} +\alias{parseOnSIDES} +\title{Parse the OnSIDES Core Relational Database} +\usage{ +parseOnSIDES(dataDir, include_high_confidence = TRUE) +} +\arguments{ +\item{dataDir}{A string specifying the path to the directory containing the +OnSIDES CSV files.} + +\item{include_high_confidence}{Logical. If TRUE (the default), the function +will also parse the `high_confidence.csv` file, which is a pre-aggregated +summary of ingredient-to-effect relationships. If the file is not found, +a warning is issued.} +} +\value{ +A list of 7 or 8 data.frames. +} +\description{ +Parses the core relational tables from the OnSIDES database. +} From 705d82050d81af5607793f0f2e22f71a0d2f5f2b Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 28 Sep 2025 15:53:19 +0300 Subject: [PATCH 05/57] #177, refactored "add_database_info" to be more generic --- R/drugbank_parser.R | 8 +++++++- R/dvobject_metadata.R | 23 ++++++++++++++--------- 2 files changed, 21 insertions(+), 10 deletions(-) diff --git a/R/drugbank_parser.R b/R/drugbank_parser.R index 9154474..37e0bc0 100644 --- a/R/drugbank_parser.R +++ b/R/drugbank_parser.R @@ -80,7 +80,13 @@ parseDrugBank <- function(db_path, message("Completed loading DrugBank DB into memory") message("...........................................") pkg_env$root <- XML::xmlRoot(parsed_db) - dvobject <- add_drugbank_info(dvobject = dvobject) + dvobject <- add_database_info(dvobject = dvobject, + db_version = XML::xmlGetAttr( + node = pkg_env$root, + name = "version"), + db_exported_date = XML::xmlGetAttr( + node = pkg_env$root, + name = "exported-on")) message("parsing drugs elements") dvobject[["drugs"]] <- parse_drug_nodes(drug_options) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index 4e6a0e8..a6f7f58 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -12,19 +12,24 @@ init_dvobject <- function() { } -#' add_drugbank_info -#' Add passed DrugBank db metadata to passed dvobject +#' add_database_info +#' Assign passed databases db metadata to passed dvobject +#' +#' @param db_type database type (defualt="DrugBank") +#' @param db_version database version as string +#' @param db_exported_date database official export date #' #' @keywords internal #' @return dvobject -add_drugbank_info <- function(dvobject) { - db_info <- attr(dvobject, "original_db_info") +add_database_info <- function(dvobject, + db_type = "DrugBank", + db_version = NULL, + db_exported_date = NULL) { + db_info <- attr(dvobject, db_type) - db_info[["db_type"]] <- "DrugBank" - db_info[["db_version"]] <- XML::xmlGetAttr(node = pkg_env$root, - name = "version") - db_info[["db_exported_date"]] <- XML::xmlGetAttr(node = pkg_env$root, - name = "exported-on") + db_info[["db_type"]] <- db_type + db_info[["db_version"]] <- db_version + db_info[["db_exported_date"]] <- db_exported_date attr(dvobject, "original_db_info") <- db_info dvobject From 2d15feeb0e7123dd8881e4e18aa2c6e046f2f54a Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 28 Sep 2025 17:33:40 +0300 Subject: [PATCH 06/57] #177, added dvobject metainfo for onside --- R/dvobject_metadata.R | 1 - R/onsides_parser.R | 17 ++++++++++++++--- man/add_database_info.Rd | 29 +++++++++++++++++++++++++++++ man/add_drugbank_info.Rd | 17 ----------------- man/cett_nodes_options.Rd | 1 + man/drug_node_options.Rd | 1 + man/parseDrugBank.Rd | 1 + man/parseOnSIDES.Rd | 21 +++++++++++++++++++-- man/references_node_options.Rd | 3 ++- 9 files changed, 67 insertions(+), 24 deletions(-) create mode 100644 man/add_database_info.Rd delete mode 100644 man/add_drugbank_info.Rd diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index a6f7f58..d5c536a 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -30,7 +30,6 @@ add_database_info <- function(dvobject, db_info[["db_type"]] <- db_type db_info[["db_version"]] <- db_version db_info[["db_exported_date"]] <- db_exported_date - attr(dvobject, "original_db_info") <- db_info dvobject } diff --git a/R/onsides_parser.R b/R/onsides_parser.R index 1e92535..85c2be0 100644 --- a/R/onsides_parser.R +++ b/R/onsides_parser.R @@ -9,12 +9,18 @@ #' will also parse the `high_confidence.csv` file, which is a pre-aggregated #' summary of ingredient-to-effect relationships. If the file is not found, #' a warning is issued. +#' @param db_version used onside version (default = NULL) +#' @param db_exported_date used onside release date (default = NULL) #' -#' @return A list of 7 or 8 data.frames. +#' @return dvobject +#' @family parsers #' #' @export #' @importFrom data.table fread -parseOnSIDES <- function(dataDir, include_high_confidence = TRUE) { +parseOnSIDES <- function(dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL) { # The 7 canonical files core_files <- c( "product_label.csv", @@ -34,6 +40,8 @@ parseOnSIDES <- function(dataDir, include_high_confidence = TRUE) { stop("Core files not found in '", dataDir, "':\n", paste(missing, collapse = "\n")) } + dvobject <- init_dvobject() + message("Parsing the 7 core OnSIDES database tables...") db_tables <- lapply(names(file_paths), function(name) { message("Reading ", name, ".csv ...") @@ -55,5 +63,8 @@ parseOnSIDES <- function(dataDir, include_high_confidence = TRUE) { message("Successfully parsed OnSIDES database.") class(db_tables) <- c("OnSIDESDb", "list") - db_tables + append(dvobject, db_tables) %>% + add_database_info(db_type = "OnSIDES", + db_version = db_version, + db_exported_date = db_exported_date) } diff --git a/man/add_database_info.Rd b/man/add_database_info.Rd new file mode 100644 index 0000000..87598b7 --- /dev/null +++ b/man/add_database_info.Rd @@ -0,0 +1,29 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{add_database_info} +\alias{add_database_info} +\title{add_database_info + Assign passed databases db metadata to passed dvobject} +\usage{ +add_database_info( + dvobject, + db_type = "DrugBank", + db_version = NULL, + db_exported_date = NULL +) +} +\arguments{ +\item{db_type}{database type (defualt="DrugBank")} + +\item{db_version}{database version as string} + +\item{db_exported_date}{database official export date} +} +\value{ +dvobject +} +\description{ +add_database_info + Assign passed databases db metadata to passed dvobject +} +\keyword{internal} diff --git a/man/add_drugbank_info.Rd b/man/add_drugbank_info.Rd deleted file mode 100644 index 2adfff8..0000000 --- a/man/add_drugbank_info.Rd +++ /dev/null @@ -1,17 +0,0 @@ -% Generated by roxygen2: do not edit by hand -% Please edit documentation in R/dvobject_metadata.R -\name{add_drugbank_info} -\alias{add_drugbank_info} -\title{add_drugbank_info - Add passed DrugBank db metadata to passed dvobject} -\usage{ -add_drugbank_info(dvobject) -} -\value{ -dvobject -} -\description{ -add_drugbank_info - Add passed DrugBank db metadata to passed dvobject -} -\keyword{internal} diff --git a/man/cett_nodes_options.Rd b/man/cett_nodes_options.Rd index 64957fe..3106647 100644 --- a/man/cett_nodes_options.Rd +++ b/man/cett_nodes_options.Rd @@ -16,6 +16,7 @@ returns carriers, enzymes,targets and transporters node valid options. Other parsers: \code{\link{drug_node_options}()}, \code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/drug_node_options.Rd b/man/drug_node_options.Rd index 51f5404..0b016ad 100644 --- a/man/drug_node_options.Rd +++ b/man/drug_node_options.Rd @@ -16,6 +16,7 @@ returns drug node valid options. Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/parseDrugBank.Rd b/man/parseDrugBank.Rd index 8f21cb3..a97a00e 100644 --- a/man/parseDrugBank.Rd +++ b/man/parseDrugBank.Rd @@ -46,6 +46,7 @@ parses given DrugBank XML database into a dvobject. dvobject is a list of Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, +\code{\link{parseOnSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/parseOnSIDES.Rd b/man/parseOnSIDES.Rd index d850084..295a4f8 100644 --- a/man/parseOnSIDES.Rd +++ b/man/parseOnSIDES.Rd @@ -4,7 +4,12 @@ \alias{parseOnSIDES} \title{Parse the OnSIDES Core Relational Database} \usage{ -parseOnSIDES(dataDir, include_high_confidence = TRUE) +parseOnSIDES( + dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL +) } \arguments{ \item{dataDir}{A string specifying the path to the directory containing the @@ -14,10 +19,22 @@ OnSIDES CSV files.} will also parse the `high_confidence.csv` file, which is a pre-aggregated summary of ingredient-to-effect relationships. If the file is not found, a warning is issued.} + +\item{db_version}{used onside version (default = NULL)} + +\item{db_exported_date}{used onside release date (default = NULL)} } \value{ -A list of 7 or 8 data.frames. +dvobject } \description{ Parses the core relational tables from the OnSIDES database. } +\seealso{ +Other parsers: +\code{\link{cett_nodes_options}()}, +\code{\link{drug_node_options}()}, +\code{\link{parseDrugBank}()}, +\code{\link{references_node_options}()} +} +\concept{parsers} diff --git a/man/references_node_options.Rd b/man/references_node_options.Rd index 74f555a..bd5dd3a 100644 --- a/man/references_node_options.Rd +++ b/man/references_node_options.Rd @@ -16,6 +16,7 @@ returns references node valid options. Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, -\code{\link{parseDrugBank}()} +\code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()} } \concept{parsers} From 65e72eb0f9cf149d1787630e417c0f32e1efa194 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 28 Sep 2025 17:33:40 +0300 Subject: [PATCH 07/57] #177, added dvobject metainfo for onside --- DESCRIPTION | 2 +- R/dvobject_metadata.R | 1 - R/onsides_parser.R | 17 ++++++++++++++--- man/add_database_info.Rd | 29 +++++++++++++++++++++++++++++ man/add_drugbank_info.Rd | 17 ----------------- man/cett_nodes_options.Rd | 1 + man/drug_node_options.Rd | 1 + man/parseDrugBank.Rd | 1 + man/parseOnSIDES.Rd | 21 +++++++++++++++++++-- man/references_node_options.Rd | 3 ++- 10 files changed, 68 insertions(+), 25 deletions(-) create mode 100644 man/add_database_info.Rd delete mode 100644 man/add_drugbank_info.Rd diff --git a/DESCRIPTION b/DESCRIPTION index d47aaf2..787bba8 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,6 +1,6 @@ Package: dbparser Title: Drugs Databases Parser -Version: 2.1.0.9000 +Version: 2.1.0.9001 Authors@R: c( person("Mohammed", "Ali", email = "moh_fcis@yahoo.com", role = c("aut", "cre")), diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index a6f7f58..d5c536a 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -30,7 +30,6 @@ add_database_info <- function(dvobject, db_info[["db_type"]] <- db_type db_info[["db_version"]] <- db_version db_info[["db_exported_date"]] <- db_exported_date - attr(dvobject, "original_db_info") <- db_info dvobject } diff --git a/R/onsides_parser.R b/R/onsides_parser.R index 1e92535..85c2be0 100644 --- a/R/onsides_parser.R +++ b/R/onsides_parser.R @@ -9,12 +9,18 @@ #' will also parse the `high_confidence.csv` file, which is a pre-aggregated #' summary of ingredient-to-effect relationships. If the file is not found, #' a warning is issued. +#' @param db_version used onside version (default = NULL) +#' @param db_exported_date used onside release date (default = NULL) #' -#' @return A list of 7 or 8 data.frames. +#' @return dvobject +#' @family parsers #' #' @export #' @importFrom data.table fread -parseOnSIDES <- function(dataDir, include_high_confidence = TRUE) { +parseOnSIDES <- function(dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL) { # The 7 canonical files core_files <- c( "product_label.csv", @@ -34,6 +40,8 @@ parseOnSIDES <- function(dataDir, include_high_confidence = TRUE) { stop("Core files not found in '", dataDir, "':\n", paste(missing, collapse = "\n")) } + dvobject <- init_dvobject() + message("Parsing the 7 core OnSIDES database tables...") db_tables <- lapply(names(file_paths), function(name) { message("Reading ", name, ".csv ...") @@ -55,5 +63,8 @@ parseOnSIDES <- function(dataDir, include_high_confidence = TRUE) { message("Successfully parsed OnSIDES database.") class(db_tables) <- c("OnSIDESDb", "list") - db_tables + append(dvobject, db_tables) %>% + add_database_info(db_type = "OnSIDES", + db_version = db_version, + db_exported_date = db_exported_date) } diff --git a/man/add_database_info.Rd b/man/add_database_info.Rd new file mode 100644 index 0000000..87598b7 --- /dev/null +++ b/man/add_database_info.Rd @@ -0,0 +1,29 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{add_database_info} +\alias{add_database_info} +\title{add_database_info + Assign passed databases db metadata to passed dvobject} +\usage{ +add_database_info( + dvobject, + db_type = "DrugBank", + db_version = NULL, + db_exported_date = NULL +) +} +\arguments{ +\item{db_type}{database type (defualt="DrugBank")} + +\item{db_version}{database version as string} + +\item{db_exported_date}{database official export date} +} +\value{ +dvobject +} +\description{ +add_database_info + Assign passed databases db metadata to passed dvobject +} +\keyword{internal} diff --git a/man/add_drugbank_info.Rd b/man/add_drugbank_info.Rd deleted file mode 100644 index 2adfff8..0000000 --- a/man/add_drugbank_info.Rd +++ /dev/null @@ -1,17 +0,0 @@ -% Generated by roxygen2: do not edit by hand -% Please edit documentation in R/dvobject_metadata.R -\name{add_drugbank_info} -\alias{add_drugbank_info} -\title{add_drugbank_info - Add passed DrugBank db metadata to passed dvobject} -\usage{ -add_drugbank_info(dvobject) -} -\value{ -dvobject -} -\description{ -add_drugbank_info - Add passed DrugBank db metadata to passed dvobject -} -\keyword{internal} diff --git a/man/cett_nodes_options.Rd b/man/cett_nodes_options.Rd index 64957fe..3106647 100644 --- a/man/cett_nodes_options.Rd +++ b/man/cett_nodes_options.Rd @@ -16,6 +16,7 @@ returns carriers, enzymes,targets and transporters node valid options. Other parsers: \code{\link{drug_node_options}()}, \code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/drug_node_options.Rd b/man/drug_node_options.Rd index 51f5404..0b016ad 100644 --- a/man/drug_node_options.Rd +++ b/man/drug_node_options.Rd @@ -16,6 +16,7 @@ returns drug node valid options. Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/parseDrugBank.Rd b/man/parseDrugBank.Rd index 8f21cb3..a97a00e 100644 --- a/man/parseDrugBank.Rd +++ b/man/parseDrugBank.Rd @@ -46,6 +46,7 @@ parses given DrugBank XML database into a dvobject. dvobject is a list of Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, +\code{\link{parseOnSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/parseOnSIDES.Rd b/man/parseOnSIDES.Rd index d850084..295a4f8 100644 --- a/man/parseOnSIDES.Rd +++ b/man/parseOnSIDES.Rd @@ -4,7 +4,12 @@ \alias{parseOnSIDES} \title{Parse the OnSIDES Core Relational Database} \usage{ -parseOnSIDES(dataDir, include_high_confidence = TRUE) +parseOnSIDES( + dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL +) } \arguments{ \item{dataDir}{A string specifying the path to the directory containing the @@ -14,10 +19,22 @@ OnSIDES CSV files.} will also parse the `high_confidence.csv` file, which is a pre-aggregated summary of ingredient-to-effect relationships. If the file is not found, a warning is issued.} + +\item{db_version}{used onside version (default = NULL)} + +\item{db_exported_date}{used onside release date (default = NULL)} } \value{ -A list of 7 or 8 data.frames. +dvobject } \description{ Parses the core relational tables from the OnSIDES database. } +\seealso{ +Other parsers: +\code{\link{cett_nodes_options}()}, +\code{\link{drug_node_options}()}, +\code{\link{parseDrugBank}()}, +\code{\link{references_node_options}()} +} +\concept{parsers} diff --git a/man/references_node_options.Rd b/man/references_node_options.Rd index 74f555a..bd5dd3a 100644 --- a/man/references_node_options.Rd +++ b/man/references_node_options.Rd @@ -16,6 +16,7 @@ returns references node valid options. Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, -\code{\link{parseDrugBank}()} +\code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()} } \concept{parsers} From 52e925f6d32126a6a0b346b1e0d10ae487dfbbf3 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 5 Oct 2025 08:33:10 +0300 Subject: [PATCH 08/57] #177, add merge drugbank and onsides databases function --- NAMESPACE | 6 ++ R/dvobject_metadata.R | 9 +-- R/merge_helpers.R | 123 ++++++++++++++++++++++++++++++++++ R/onsides_parser.R | 11 ++- man/merge_drugbank_onsides.Rd | 63 +++++++++++++++++ 5 files changed, 201 insertions(+), 11 deletions(-) create mode 100644 R/merge_helpers.R create mode 100644 man/merge_drugbank_onsides.Rd diff --git a/NAMESPACE b/NAMESPACE index ae1807f..77dc3a3 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -2,6 +2,7 @@ export(cett_nodes_options) export(drug_node_options) +export(merge_drugbank_onsides) export(parseDrugBank) export(parseOnSIDES) export(references_node_options) @@ -18,6 +19,11 @@ importFrom(XML,xmlToDataFrame) importFrom(XML,xmlToList) importFrom(XML,xmlValue) importFrom(data.table,fread) +importFrom(dplyr,filter) +importFrom(dplyr,left_join) +importFrom(dplyr,mutate) +importFrom(dplyr,rename) +importFrom(dplyr,select) importFrom(progress,progress_bar) importFrom(purrr,'%>%') importFrom(purrr,is_empty) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index d5c536a..ff3a8e6 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -27,10 +27,11 @@ add_database_info <- function(dvobject, db_exported_date = NULL) { db_info <- attr(dvobject, db_type) - db_info[["db_type"]] <- db_type - db_info[["db_version"]] <- db_version - db_info[["db_exported_date"]] <- db_exported_date + db_info[["db_type"]] <- db_type + db_info[["db_version"]] <- db_version + db_info[["db_exported_date"]] <- db_exported_date attr(dvobject, "original_db_info") <- db_info + class(dvobject) <- "dvobject" dvobject } @@ -45,6 +46,6 @@ add_database_info <- function(dvobject, #' @export show_dvobject_metadata <- function(dvobject) { dvobject_attributes <- attr(dvobject, "original_db_info") - dvobject_attributes[["class"]] <- class(dvobject) + dvobject_attributes[["class"]] <- class(merged_db) %>% paste(collapse = ", ") data.frame(Atrribute = names(dvobject_attributes), Value = stack(dvobject_attributes)[[1]]) } diff --git a/R/merge_helpers.R b/R/merge_helpers.R new file mode 100644 index 0000000..1c47916 --- /dev/null +++ b/R/merge_helpers.R @@ -0,0 +1,123 @@ +#' Merge DrugBank and OnSIDES Database Objects +#' +#' Creates an integrated dvobject object by linking DrugBank dvobject with +#' OnSIDES dvobject using RxNorm CUIs as the bridge. +#' +#' @details +#' This function performs the following key steps: +#' 1. Creates a mapping table between DrugBank IDs and RxNorm CUIs from the DrugBank object. +#' 2. Enriches the relevant OnSIDES tables (`vocab_rxnorm_ingredient` and optionally +#' `high_confidence`) by adding a `drugbank_id` column. +#' 3. Assembles a new list object containing all original tables plus the enriched ones +#' and the ID mapping table itself. +#' +#' The resulting object allows for powerful queries that span both mechanistic data from +#' DrugBank and clinical side-effect data from OnSIDES. +#' +#' @param drugbank A dvobject produced by `dbparser::parseDrugBank()`. +#' @param onsides A dvobject produced by `dbparser::parseOnSIDES()`. +#' +#' @return A new dvobject containing the integrated data. +#' +#' @export +#' @importFrom dplyr filter select rename mutate left_join +#' +#' @examples +#' \dontrun{ +#' # First, parse the individual databases +#' drugbank <- parseDrugBank("path/to/drugbank.xml") +#' onsides <- parseOnSIDES("path/to/onsides_csvs/") +#' +#' # Now, merge them into a single, powerful object +#' merged_db <- merge_drugbank_onsides(drugbank, onsides) +#' +#' # --- Example Analysis: Find the protein targets of all drugs known to --- +#' # --- cause the side effect "Hepatitis" with high confidence. --- +#' +#' # 1. Find the MedDRA ID for "Hepatitis" +#' hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% +#' filter(meddra_name == "Hepatitis") %>% +#' pull(meddra_id) +#' +#' # 2. Find all drug ingredients linked to this effect in the high_confidence table +#' drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% +#' filter(effect_meddra_id == hepatitis_id) %>% +#' pull(drugbank_id) %>% +#' na.omit() %>% +#' unique() +#' +#' # 3. Look up the targets for these DrugBank IDs +#' targets_of_interest <- merged_db$targets %>% +#' filter(parent_key %in% drug_ids_causing_hepatitis) %>% +#' select(drug_id = parent_key, target_name = name, gene_name) +#' +#' head(targets_of_interest) +#' } +merge_drugbank_onsides <- function(drugbank_db, onsides_db) { + + # --- Step 0: Input Validation --- + if (!inherits(drugbank_db, "dvobject") || + (!"drugs" %in% names(drugbank_db))) { + stop("`drugbank_db` must be a valid dvobject from parseDrugBank().") + } + + if (!inherits(drugbank_db, "dvobject") || + (!"external_identifiers" %in% names(drugbank_db$drugs))) { + stop("`drugbank_db` dvobject must contain external_identifiers data.") + } + + if (!inherits(onsides_db, "dvobject") || + (!"vocab_rxnorm_ingredient" %in% names(onsides_db))) { + stop("`onsides_db` must be a valid dvobject from parseOnSIDES().") + } + + # --- Step 1: Create the Bridge (RxCUI Mapping Table) --- + message("Creating DrugBank ID <-> RxCUI mapping table...") + rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% + dplyr::filter(resource == "RxCUI") %>% + dplyr::select(drugbank_id, rxcui = identifier) + + # --- Step 2: Enrich OnSIDES Tables --- + message("Enriching OnSIDES tables with DrugBank IDs...") + + # Enrich the core ingredient vocabulary + onsides_ingredient_enriched <- onsides_db$vocab_rxnorm_ingredient %>% + dplyr::left_join(rxcui_mapping_df, by = c("rxnorm_id" = "rxcui")) + + # Optionally enrich the high_confidence table if it exists + if ("high_confidence" %in% names(onsides_db)) { + onsides_hc_enriched <- onsides_db$high_confidence %>% + dplyr::mutate(ingredient_id = as.character(ingredient_id)) %>% + dplyr::left_join(rxcui_mapping_df, by = c("ingredient_id" = "rxcui")) + } + + # --- Step 3: Assemble the Final Merged Object --- + message("Assembling final merged object...") + + # Start with all of DrugBank's data + merged_object <- drugbank_db + merged_object$onsides <- list() + + # Add all of OnSIDES's data + for (name in names(onsides_db)) { + merged_object$onsides[[name]] <- onsides_db[[name]] + } + + # Overwrite the original OnSIDES tables with our new enriched versions + merged_object$vocab_rxnorm_ingredient_enriched <- onsides_ingredient_enriched + if (exists("onsides_hc_enriched")) { + merged_object$onsides$high_confidence_enriched <- onsides_hc_enriched + } + + # Add the mapping table itself for user reference + merged_object$drugbank_onsides_mapping <- rxcui_mapping_df + + # Update metadata + attr(merged_object, "onSideDB") <- attr(onsides_db, "original_db_info") + + # Assign a new class + class(merged_object) <- c("DrugBankOnSIDESDb", class(merged_object)) + + message("Merge complete.") + merged_object +} diff --git a/R/onsides_parser.R b/R/onsides_parser.R index 85c2be0..d92bf7d 100644 --- a/R/onsides_parser.R +++ b/R/onsides_parser.R @@ -40,8 +40,6 @@ parseOnSIDES <- function(dataDir, stop("Core files not found in '", dataDir, "':\n", paste(missing, collapse = "\n")) } - dvobject <- init_dvobject() - message("Parsing the 7 core OnSIDES database tables...") db_tables <- lapply(names(file_paths), function(name) { message("Reading ", name, ".csv ...") @@ -62,9 +60,8 @@ parseOnSIDES <- function(dataDir, } message("Successfully parsed OnSIDES database.") - class(db_tables) <- c("OnSIDESDb", "list") - append(dvobject, db_tables) %>% - add_database_info(db_type = "OnSIDES", - db_version = db_version, - db_exported_date = db_exported_date) + db_tables <- add_database_info(dvobject = db_tables, + db_type = "OnSIDES", + db_version = db_version, + db_exported_date = db_exported_date) } diff --git a/man/merge_drugbank_onsides.Rd b/man/merge_drugbank_onsides.Rd new file mode 100644 index 0000000..23574fe --- /dev/null +++ b/man/merge_drugbank_onsides.Rd @@ -0,0 +1,63 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/merge_helpers.R +\name{merge_drugbank_onsides} +\alias{merge_drugbank_onsides} +\title{Merge DrugBank and OnSIDES Database Objects} +\usage{ +merge_drugbank_onsides(drugbank_db, onsides_db) +} +\arguments{ +\item{drugbank}{A dvobject produced by `dbparser::parseDrugBank()`.} + +\item{onsides}{A dvobject produced by `dbparser::parseOnSIDES()`.} +} +\value{ +A new dvobject containing the integrated data. +} +\description{ +Creates an integrated dvobject object by linking DrugBank dvobject with +OnSIDES dvobject using RxNorm CUIs as the bridge. +} +\details{ +This function performs the following key steps: +1. Creates a mapping table between DrugBank IDs and RxNorm CUIs from the DrugBank object. +2. Enriches the relevant OnSIDES tables (`vocab_rxnorm_ingredient` and optionally + `high_confidence`) by adding a `drugbank_id` column. +3. Assembles a new list object containing all original tables plus the enriched ones + and the ID mapping table itself. + +The resulting object allows for powerful queries that span both mechanistic data from +DrugBank and clinical side-effect data from OnSIDES. +} +\examples{ +\dontrun{ +# First, parse the individual databases +drugbank <- parseDrugBank("path/to/drugbank.xml") +onsides <- parseOnSIDES("path/to/onsides_csvs/") + +# Now, merge them into a single, powerful object +merged_db <- merge_drugbank_onsides(drugbank, onsides) + +# --- Example Analysis: Find the protein targets of all drugs known to --- +# --- cause the side effect "Hepatitis" with high confidence. --- + +# 1. Find the MedDRA ID for "Hepatitis" +hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect \%>\% + filter(meddra_name == "Hepatitis") \%>\% + pull(meddra_id) + +# 2. Find all drug ingredients linked to this effect in the high_confidence table +drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched \%>\% + filter(effect_meddra_id == hepatitis_id) \%>\% + pull(drugbank_id) \%>\% + na.omit() \%>\% + unique() + +# 3. Look up the targets for these DrugBank IDs +targets_of_interest <- merged_db$targets \%>\% + filter(parent_key \%in\% drug_ids_causing_hepatitis) \%>\% + select(drug_id = parent_key, target_name = name, gene_name) + +head(targets_of_interest) +} +} From 7c47d4662645c577decdbd7a4438f4881dd93c95 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 5 Oct 2025 09:59:53 +0300 Subject: [PATCH 09/57] #177, updated show dvobject meta data function --- R/dvobject_metadata.R | 186 +++++++++++++++++++++++++++++-- man/build_metadata.Rd | 22 ++++ man/count_top_level_lists.Rd | 18 +++ man/find_dataframes_recursive.Rd | 20 ++++ man/find_second_database.Rd | 18 +++ man/grapes-or-or-grapes.Rd | 12 ++ man/show_dvobject_metadata.Rd | 24 ++-- 7 files changed, 283 insertions(+), 17 deletions(-) create mode 100644 man/build_metadata.Rd create mode 100644 man/count_top_level_lists.Rd create mode 100644 man/find_dataframes_recursive.Rd create mode 100644 man/find_second_database.Rd create mode 100644 man/grapes-or-or-grapes.Rd diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index ff3a8e6..4aed599 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -36,16 +36,184 @@ add_database_info <- function(dvobject, } -#' init_dvobject -#' Returns data.frame with two columns (key, value) of dvobject attributes +#' Display dvobject Metadata +#' +#' Displays information about passed dbobject object including basic info, +#' database metadata, and all data.frames contained within nested lists. +#' +#' @param obj A dvobject +#' @param return_df Logical. If TRUE, returns metadata data.frame without printing. +#' Default is FALSE. #' -#' @param dvobject - dvobject list to show related metadata +#' @return Invisibly returns a data.frame containing dvobject metadata +#' +#' @examples +#' \dontrun{ +#' display_merged_db_attrs(drugbank) +#' metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) +#' } #' -#' @return data.frame -#' @family utility #' @export -show_dvobject_metadata <- function(dvobject) { - dvobject_attributes <- attr(dvobject, "original_db_info") - dvobject_attributes[["class"]] <- class(merged_db) %>% paste(collapse = ", ") - data.frame(Atrribute = names(dvobject_attributes), Value = stack(dvobject_attributes)[[1]]) +show_dvobject_metadata <- function(obj, return_df = FALSE) { + # Initialize return variable + metadata <- NULL + + # Validate input + attrs <- attributes(obj) + + if (is.null(attrs) || is.null(attrs$original_db_info)) { + stop("Object does not have expected database attributes (missing 'original_db_info')") + } + + # Find all dataframes in object + df_info <- find_dataframes_recursive(obj) + + # Count only top-level lists (not data.frames) + top_level_lists <- count_top_level_lists(obj) + + # Find second database if it exists + second_db_info <- find_second_database(attrs) + + # Build metadata + metadata <- build_metadata( + attrs = attrs, + has_second_db = second_db_info$has_second_db, + second_db_name = second_db_info$second_db_name + ) + + # Display output if not returning data.frame + if (!return_df) { + cat("=== BASIC INFO ===\n") + basic_info <- data.frame( + Class = paste(attrs$class, collapse = ", "), + Total_DataFrames = nrow(df_info), + Top_Level_Lists = top_level_lists, + Object_Size = format(object.size(obj), units = "auto"), + stringsAsFactors = FALSE + ) + print(basic_info) + + cat("\n=== DATABASE METADATA ===\n") + print(metadata, row.names = FALSE) + + cat("\n=== DATA.FRAMES ===\n") + print(df_info, row.names = FALSE) + } + + # Return metadata + invisible(metadata) +} + + +# Helper Functions for Display Attributes +# These are internal functions not exported to users + +#' NULL Coalescing Operator +#' @keywords internal +`%||%` <- function(x, y) { + if (is.null(x)) y else x +} + +#' Find All Data Frames Recursively +#' @param x Object to search +#' @param prefix Current path prefix +#' @return Data.frame with paths, dimensions, and sizes +#' @keywords internal +find_dataframes_recursive <- function(x, prefix = "") { + result <- NULL + + if (is.data.frame(x)) { + result <- data.frame( + Path = prefix, + Rows = nrow(x), + Cols = ncol(x), + Size = format(object.size(x), units = "auto"), + stringsAsFactors = FALSE + ) + } else if (is.list(x) && (length(x) > 0)) { + results <- lapply(names(x), function(name) { + new_prefix <- if (prefix == "") name else paste0(prefix, "$", name) + find_dataframes_recursive(x[[name]], new_prefix) + }) + result <- do.call(rbind, results[!sapply(results, is.null)]) + } + + result +} + +#' Count Top Level Lists +#' @param obj Object to analyze +#' @return Integer count of top-level lists (excluding data.frames) +#' @keywords internal +count_top_level_lists <- function(obj) { + sum(sapply(obj, function(x) { + (is.list(x) && !is.data.frame(x)) + })) +} + +#' Find Second Database in Attributes +#' @param attrs Attributes list +#' @return List with has_second_db (logical) and second_db_name (character) +#' @keywords internal +find_second_database <- function(attrs) { + result <- list( + has_second_db = FALSE, + second_db_name = NULL + ) + + standard_attrs <- c("names", "class", "original_db_info", "row.names") + potential_second_db <- setdiff(names(attrs), standard_attrs) + + if (length(potential_second_db) > 0) { + for (db_name in potential_second_db) { + db_attr <- attrs[[db_name]] + required_fields <- c("db_type", "db_version", "db_exported_date") + + if ((is.list(db_attr)) && (all(required_fields %in% names(db_attr)))) { + result$has_second_db <- TRUE + result$second_db_name <- db_name + } + } + } + + result +} + +#' Build Metadata Data Frame +#' @param attrs Attributes list +#' @param has_second_db Logical indicating if second database exists +#' @param second_db_name Name of second database attribute +#' @return Data.frame with database metadata +#' @keywords internal +build_metadata <- function(attrs, has_second_db, second_db_name) { + metadata <- NULL + + if (has_second_db) { + metadata <- rbind( + data.frame( + Database = "First Database", + Type = attrs$original_db_info$db_type %||% "Unknown", + Version = attrs$original_db_info$db_version %||% "Unknown", + Export_Date = attrs$original_db_info$db_exported_date %||% "Unknown", + stringsAsFactors = FALSE + ), + data.frame( + Database = "Second Database", + Type = attrs[[second_db_name]]$db_type %||% "Unknown", + Version = attrs[[second_db_name]]$db_version %||% "Unknown", + Export_Date = attrs[[second_db_name]]$db_exported_date %||% "Unknown", + stringsAsFactors = FALSE + ) + ) + } else { + metadata <- data.frame( + Database = "Original", + Type = attrs$original_db_info$db_type %||% "Unknown", + Version = attrs$original_db_info$db_version %||% "Unknown", + Export_Date = attrs$original_db_info$db_exported_date %||% "Unknown", + stringsAsFactors = FALSE + ) + } + + metadata } diff --git a/man/build_metadata.Rd b/man/build_metadata.Rd new file mode 100644 index 0000000..a8f169f --- /dev/null +++ b/man/build_metadata.Rd @@ -0,0 +1,22 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{build_metadata} +\alias{build_metadata} +\title{Build Metadata Data Frame} +\usage{ +build_metadata(attrs, has_second_db, second_db_name) +} +\arguments{ +\item{attrs}{Attributes list} + +\item{has_second_db}{Logical indicating if second database exists} + +\item{second_db_name}{Name of second database attribute} +} +\value{ +Data.frame with database metadata +} +\description{ +Build Metadata Data Frame +} +\keyword{internal} diff --git a/man/count_top_level_lists.Rd b/man/count_top_level_lists.Rd new file mode 100644 index 0000000..eeff527 --- /dev/null +++ b/man/count_top_level_lists.Rd @@ -0,0 +1,18 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{count_top_level_lists} +\alias{count_top_level_lists} +\title{Count Top Level Lists} +\usage{ +count_top_level_lists(obj) +} +\arguments{ +\item{obj}{Object to analyze} +} +\value{ +Integer count of top-level lists (excluding data.frames) +} +\description{ +Count Top Level Lists +} +\keyword{internal} diff --git a/man/find_dataframes_recursive.Rd b/man/find_dataframes_recursive.Rd new file mode 100644 index 0000000..898a44f --- /dev/null +++ b/man/find_dataframes_recursive.Rd @@ -0,0 +1,20 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{find_dataframes_recursive} +\alias{find_dataframes_recursive} +\title{Find All Data Frames Recursively} +\usage{ +find_dataframes_recursive(x, prefix = "") +} +\arguments{ +\item{x}{Object to search} + +\item{prefix}{Current path prefix} +} +\value{ +Data.frame with paths, dimensions, and sizes +} +\description{ +Find All Data Frames Recursively +} +\keyword{internal} diff --git a/man/find_second_database.Rd b/man/find_second_database.Rd new file mode 100644 index 0000000..eb00f74 --- /dev/null +++ b/man/find_second_database.Rd @@ -0,0 +1,18 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{find_second_database} +\alias{find_second_database} +\title{Find Second Database in Attributes} +\usage{ +find_second_database(attrs) +} +\arguments{ +\item{attrs}{Attributes list} +} +\value{ +List with has_second_db (logical) and second_db_name (character) +} +\description{ +Find Second Database in Attributes +} +\keyword{internal} diff --git a/man/grapes-or-or-grapes.Rd b/man/grapes-or-or-grapes.Rd new file mode 100644 index 0000000..aaf7f3d --- /dev/null +++ b/man/grapes-or-or-grapes.Rd @@ -0,0 +1,12 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{\%||\%} +\alias{\%||\%} +\title{NULL Coalescing Operator} +\usage{ +x \%||\% y +} +\description{ +NULL Coalescing Operator +} +\keyword{internal} diff --git a/man/show_dvobject_metadata.Rd b/man/show_dvobject_metadata.Rd index ab2fa55..aaa3e24 100644 --- a/man/show_dvobject_metadata.Rd +++ b/man/show_dvobject_metadata.Rd @@ -2,19 +2,27 @@ % Please edit documentation in R/dvobject_metadata.R \name{show_dvobject_metadata} \alias{show_dvobject_metadata} -\title{init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes} +\title{Display dvobject Metadata} \usage{ -show_dvobject_metadata(dvobject) +show_dvobject_metadata(obj, return_df = FALSE) } \arguments{ -\item{dvobject}{- dvobject list to show related metadata} +\item{obj}{A dvobject} + +\item{return_df}{Logical. If TRUE, returns metadata data.frame without printing. +Default is FALSE.} } \value{ -data.frame +Invisibly returns a data.frame containing dvobject metadata } \description{ -init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes +Displays information about passed dbobject object including basic info, +database metadata, and all data.frames contained within nested lists. +} +\examples{ +\dontrun{ +display_merged_db_attrs(drugbank) +metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) +} + } -\concept{utility} From 21926e2c488b9eba85c77c03aedd2be5fd372c8c Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 5 Oct 2025 18:16:36 +0300 Subject: [PATCH 10/57] - Fixed unit tests --- tests/testthat/test_dvobject_metadata.R | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/tests/testthat/test_dvobject_metadata.R b/tests/testthat/test_dvobject_metadata.R index 5f8dc6c..d5d9afd 100644 --- a/tests/testthat/test_dvobject_metadata.R +++ b/tests/testthat/test_dvobject_metadata.R @@ -22,9 +22,9 @@ test_that( dvobj <- parseDrugBank(db_location) metadata <- dbparser::show_dvobject_metadata(dvobj) - expect_match(metadata$Value[[1]], "DrugBank") - expect_match(metadata$Value[[2]], "5.1") - expect_match(metadata$Value[[3]], "2018-07-03") - expect_match(metadata$Value[[4]], "dvobject") + expect_match(metadata$Database, "Original") + expect_match(metadata$Type, "DrugBank") + expect_match(metadata$Export_Date, "2018-07-03") + expect_match(metadata$Version, "5.1") } ) From 52504207c9a2f8e0fa1342d2ec76f832121508fc Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Mon, 6 Oct 2025 18:49:10 +0300 Subject: [PATCH 11/57] #177, added missed imports --- DESCRIPTION | 1 + NAMESPACE | 2 ++ R/dvobject_metadata.R | 1 + 3 files changed, 4 insertions(+) diff --git a/DESCRIPTION b/DESCRIPTION index 787bba8..ad67057 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -18,6 +18,7 @@ Imports: purrr, tibble, tools, + utils, XML RoxygenNote: 7.3.3 Suggests: diff --git a/NAMESPACE b/NAMESPACE index 77dc3a3..f0a577f 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -19,6 +19,7 @@ importFrom(XML,xmlToDataFrame) importFrom(XML,xmlToList) importFrom(XML,xmlValue) importFrom(data.table,fread) +importFrom(dplyr,.data) importFrom(dplyr,filter) importFrom(dplyr,left_join) importFrom(dplyr,mutate) @@ -34,5 +35,6 @@ importFrom(tibble,as_tibble) importFrom(tibble,as_tibble_row) importFrom(tibble,tibble) importFrom(tibble,tibble_row) +importFrom(utils,object.size) importFrom(utils,stack) importFrom(utils,unzip) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index 4aed599..629d140 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -54,6 +54,7 @@ add_database_info <- function(dvobject, #' } #' #' @export +#' @importFrom utils object.size show_dvobject_metadata <- function(obj, return_df = FALSE) { # Initialize return variable metadata <- NULL From 2b87ca52c4cb59d725442e015a554dea244c3acf Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Mon, 6 Oct 2025 18:49:43 +0300 Subject: [PATCH 12/57] #177, fixed global variables issue --- R/merge_helpers.R | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 1c47916..3985b48 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -20,7 +20,7 @@ #' @return A new dvobject containing the integrated data. #' #' @export -#' @importFrom dplyr filter select rename mutate left_join +#' @importFrom dplyr .data filter select rename mutate left_join #' #' @examples #' \dontrun{ @@ -74,8 +74,8 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { # --- Step 1: Create the Bridge (RxCUI Mapping Table) --- message("Creating DrugBank ID <-> RxCUI mapping table...") rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% - dplyr::filter(resource == "RxCUI") %>% - dplyr::select(drugbank_id, rxcui = identifier) + dplyr::filter(.data$resource == "RxCUI") %>% + dplyr::select(.data$drugbank_id, rxcui = .data$identifier) # --- Step 2: Enrich OnSIDES Tables --- message("Enriching OnSIDES tables with DrugBank IDs...") @@ -87,7 +87,7 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { # Optionally enrich the high_confidence table if it exists if ("high_confidence" %in% names(onsides_db)) { onsides_hc_enriched <- onsides_db$high_confidence %>% - dplyr::mutate(ingredient_id = as.character(ingredient_id)) %>% + dplyr::mutate(ingredient_id = as.character(.data$ingredient_id)) %>% dplyr::left_join(rxcui_mapping_df, by = c("ingredient_id" = "rxcui")) } From a82577fa4c064f998f3099a95041df99f8d194fa Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Mon, 6 Oct 2025 18:54:17 +0300 Subject: [PATCH 13/57] #177, fixed function param documentation --- R/merge_helpers.R | 4 ++-- man/merge_drugbank_onsides.Rd | 4 ++-- 2 files changed, 4 insertions(+), 4 deletions(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 3985b48..d39b7ac 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -14,8 +14,8 @@ #' The resulting object allows for powerful queries that span both mechanistic data from #' DrugBank and clinical side-effect data from OnSIDES. #' -#' @param drugbank A dvobject produced by `dbparser::parseDrugBank()`. -#' @param onsides A dvobject produced by `dbparser::parseOnSIDES()`. +#' @param drugbank_db A dvobject produced by `dbparser::parseDrugBank()`. +#' @param onsides_db A dvobject produced by `dbparser::parseOnSIDES()`. #' #' @return A new dvobject containing the integrated data. #' diff --git a/man/merge_drugbank_onsides.Rd b/man/merge_drugbank_onsides.Rd index 23574fe..f67afc4 100644 --- a/man/merge_drugbank_onsides.Rd +++ b/man/merge_drugbank_onsides.Rd @@ -7,9 +7,9 @@ merge_drugbank_onsides(drugbank_db, onsides_db) } \arguments{ -\item{drugbank}{A dvobject produced by `dbparser::parseDrugBank()`.} +\item{drugbank_db}{A dvobject produced by `dbparser::parseDrugBank()`.} -\item{onsides}{A dvobject produced by `dbparser::parseOnSIDES()`.} +\item{onsides_db}{A dvobject produced by `dbparser::parseOnSIDES()`.} } \value{ A new dvobject containing the integrated data. From beb2039848e761bf5000a42be667130ac43c8f5c Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Wed, 8 Oct 2025 16:19:43 +0300 Subject: [PATCH 14/57] #177, imported null operator from purrr and fixed CMD warning --- NAMESPACE | 1 + R/dvobject_metadata.R | 7 +------ man/grapes-or-or-grapes.Rd | 12 ------------ 3 files changed, 2 insertions(+), 18 deletions(-) delete mode 100644 man/grapes-or-or-grapes.Rd diff --git a/NAMESPACE b/NAMESPACE index f0a577f..12f532a 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -26,6 +26,7 @@ importFrom(dplyr,mutate) importFrom(dplyr,rename) importFrom(dplyr,select) importFrom(progress,progress_bar) +importFrom(purrr,"%||%") importFrom(purrr,'%>%') importFrom(purrr,is_empty) importFrom(purrr,is_null) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index 629d140..65cdd20 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -109,12 +109,6 @@ show_dvobject_metadata <- function(obj, return_df = FALSE) { # Helper Functions for Display Attributes # These are internal functions not exported to users -#' NULL Coalescing Operator -#' @keywords internal -`%||%` <- function(x, y) { - if (is.null(x)) y else x -} - #' Find All Data Frames Recursively #' @param x Object to search #' @param prefix Current path prefix @@ -186,6 +180,7 @@ find_second_database <- function(attrs) { #' @param second_db_name Name of second database attribute #' @return Data.frame with database metadata #' @keywords internal +#' @importFrom purrr %||% build_metadata <- function(attrs, has_second_db, second_db_name) { metadata <- NULL diff --git a/man/grapes-or-or-grapes.Rd b/man/grapes-or-or-grapes.Rd deleted file mode 100644 index aaf7f3d..0000000 --- a/man/grapes-or-or-grapes.Rd +++ /dev/null @@ -1,12 +0,0 @@ -% Generated by roxygen2: do not edit by hand -% Please edit documentation in R/dvobject_metadata.R -\name{\%||\%} -\alias{\%||\%} -\title{NULL Coalescing Operator} -\usage{ -x \%||\% y -} -\description{ -NULL Coalescing Operator -} -\keyword{internal} From 929e6772e85950e907881d6de93c54cab332a399 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Tue, 25 Nov 2025 23:14:33 +0200 Subject: [PATCH 15/57] #177, Added util functions and docs --- NAMESPACE | 2 + R/dvobject_metadata.R | 3 +- R/merge_helpers.R | 11 +- R/utils.R | 228 ++++++++++++++++++++++++++++++++ man/add_database_info.Rd | 1 - man/subset_drugbank_dvobject.Rd | 31 +++++ vignettes/drugbank_nside.Rmd | 109 +++++++++++++++ 7 files changed, 378 insertions(+), 7 deletions(-) create mode 100644 R/utils.R create mode 100644 man/subset_drugbank_dvobject.Rd create mode 100644 vignettes/drugbank_nside.Rmd diff --git a/NAMESPACE b/NAMESPACE index 12f532a..62809af 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -1,5 +1,6 @@ # Generated by roxygen2: do not edit by hand +export(add_database_info) export(cett_nodes_options) export(drug_node_options) export(merge_drugbank_onsides) @@ -7,6 +8,7 @@ export(parseDrugBank) export(parseOnSIDES) export(references_node_options) export(show_dvobject_metadata) +export(subset_drugbank_dvobject) import(dplyr) importFrom(XML,xmlApply) importFrom(XML,xmlChildren) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index 65cdd20..d8e3dcd 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -19,8 +19,9 @@ init_dvobject <- function() { #' @param db_version database version as string #' @param db_exported_date database official export date #' -#' @keywords internal #' @return dvobject +#' @export +#' @importFrom dplyr .data filter select rename mutate left_join add_database_info <- function(dvobject, db_type = "DrugBank", db_version = NULL, diff --git a/R/merge_helpers.R b/R/merge_helpers.R index d39b7ac..18b38da 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -54,7 +54,6 @@ #' head(targets_of_interest) #' } merge_drugbank_onsides <- function(drugbank_db, onsides_db) { - # --- Step 0: Input Validation --- if (!inherits(drugbank_db, "dvobject") || (!"drugs" %in% names(drugbank_db))) { @@ -95,8 +94,10 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { message("Assembling final merged object...") # Start with all of DrugBank's data - merged_object <- drugbank_db - merged_object$onsides <- list() + merged_object <- list() + merged_object$drugbank <- drugbank_db + merged_object$onsides <- list() + merged_object$integrated_data <- list() # Add all of OnSIDES's data for (name in names(onsides_db)) { @@ -106,11 +107,11 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { # Overwrite the original OnSIDES tables with our new enriched versions merged_object$vocab_rxnorm_ingredient_enriched <- onsides_ingredient_enriched if (exists("onsides_hc_enriched")) { - merged_object$onsides$high_confidence_enriched <- onsides_hc_enriched + merged_object$integrated_data[["high_confidence_enriched"]] <- onsides_hc_enriched } # Add the mapping table itself for user reference - merged_object$drugbank_onsides_mapping <- rxcui_mapping_df + merged_object$integrated_data[["DrugBank_RxCUI_Mapping"]] <- rxcui_mapping_df # Update metadata attr(merged_object, "onSideDB") <- attr(onsides_db, "original_db_info") diff --git a/R/utils.R b/R/utils.R new file mode 100644 index 0000000..1bbea59 --- /dev/null +++ b/R/utils.R @@ -0,0 +1,228 @@ +# Create a reusable helper function to process one component (carrier, enzyme, etc.) +subset_cett_component <- function(component, component_name, drug_ids) { + new_component <- list() + + if (!is.null(component)) { + # The name of the intermediate ID, e.g., "carrier_id", "target_id" + intermediate_id_col <- paste0(sub("s$", "", component_name), "_id") + + # Step A: Filter the top-level `general_information` table by drug_id. + # This is our anchor. + general_info_filtered <- component$general_information %>% + dplyr::filter(drugbank_id %in% drug_ids) + + # Step B: From this anchor, get the set of relevant intermediate IDs. + relevant_intermediate_ids <- general_info_filtered[[intermediate_id_col]] %>% + unique() + # No matching items for this component + if (length(relevant_intermediate_ids) > 0) { + # Step C: Use these intermediate IDs to filter all other tables in the component. + new_component <- list() + new_component$general_information <- general_info_filtered + new_component$actions <- component$actions %>% + dplyr::filter(.data[[intermediate_id_col]] %in% relevant_intermediate_ids) + + # Step D: Recurse into the `polypeptides` list, using the same intermediate IDs + if (!is.null(component$polypeptides)) { + new_component$polypeptides <- list() + for (poly_table_name in names(component$polypeptides)) { + poly_table <- component$polypeptides[[poly_table_name]] + if (is.data.frame(poly_table) && intermediate_id_col %in% names(poly_table)) { + new_component$polypeptides[[poly_table_name]] <- poly_table %>% + dplyr::filter(.data[[intermediate_id_col]] %in% relevant_intermediate_ids) + } + } + } + } + } + + new_component +} + + +#' Subset a DrugBank dvobject by a vector of DrugBank IDs +#' +#' @details +#' Intelligently filters a DrugBank dvobject to retain only the data associated +#' with a specified list of drugbank_ids. It correctly handles the deep, +#' multi-level nested structure of the entire object, including the complex +#' relationships within the `cett` list. +#' +#' @param dvobject The dvobject from `parseDrugBank()`. +#' @param drug_ids A character vector of `drugbank_id` values to keep. +#' +#' @return A new, smaller dvobject with the same structure and attributes. +#' +#' @export +#' @importFrom dplyr .data filter +#' +#' @examples +#' \dontrun{ +#' library(dbparser) +#' one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, +#' drug_ids = "DB00001") +#' } +subset_drugbank_dvobject <- function(dvobject, drug_ids) { + + new_dvobject <- list() + + if (length(drug_ids) == 0) { + warning("`drug_ids` is empty. Returning an empty structure.") + } else { + # --- 1. Filter the `drugs` list (many sub-tables) --- + if (!is.null(dvobject$drugs)) { + message("Subsetting `drugs` list...") + new_dvobject$drugs <- list() + for (name in names(dvobject$drugs)) { + sub_table <- dvobject$drugs[[name]] + # Most tables here link directly via drugbank_id + if (is.data.frame(sub_table) && ("drugbank_id" %in% names(sub_table))) { + filtered_subtable<- sub_table %>% + dplyr::filter(drugbank_id %in% drug_ids) + if (NROW(filtered_subtable) > 0) { + new_dvobject$drugs[[name]] <- filtered_subtable + } + } + } + } + + # --- 2. Filter the `salts`, `products` data.frames --- + for (name in c("salts", "products")) { + if (!is.null(dvobject[[name]])) { + message(paste("Subsetting", name, "...")) + filtered_subtable <- dvobject[[name]] %>% + dplyr::filter(drugbank_id %in% drug_ids) + if (NROW(filtered_subtable) > 0) { + new_dvobject$drugs[[name]] <- filtered_subtable + } + } + } + + # --- 3. Filter the drugs`references` list --- + if (!is.null(dvobject$references) && !is.null(dvobject$references$drugs)) { + message("Subsetting drugs `references` list...") + new_dvobject$references$drugs <- list() + for (name in names(dvobject$references$drugs)) { + sub_table <- dvobject$references$drugs[[name]] + if (is.data.frame(sub_table) && "drugbank_id" %in% names(sub_table)) { + filtered_subtable <- sub_table %>% + dplyr::filter(drugbank_id %in% drug_ids) + if (NROW(filtered_subtable) > 0) { + new_dvobject$references$drugs[[name]] <- filtered_subtable + } + } + } + } + } + + # --- 4. Filter the complex, multi-level `cett` List --- + if (!is.null(dvobject$cett)) { + message("Subsetting complex `cett` list...") + new_dvobject$cett <- list() + + # Apply the helper to each component within cett + for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { + component <- subset_cett_component( + component = dvobject$cett[[cett_name]], + component_name = cett_name, + drug_ids = drug_ids) + + if (length(component) > 0) { + new_dvobject$cett[[cett_name]] <- component + } + } + } + + # --- 5. Filter the CETT`references` list --- + if (!is.null(dvobject$references)) { + for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { + if ((length(dvobject$references[[cett_name]]) > 0) && + (length(new_dvobject$cett[[cett_name]]) > 0)) { + message("Subsetting ", cett_name ," references list...") + cett_references <- list() + # The name of the intermediate ID, e.g., "carrier_id", "target_id" + intermediate_id_col <- paste0(sub("s$", "", cett_name), "_id") + + for (name in names(dvobject$references[[cett_name]])) { + sub_table <- dvobject$references[[cett_name]][[name]] + if (is.data.frame(sub_table) && (intermediate_id_col %in% names(sub_table))) { + filtered_subtable <- sub_table %>% + dplyr::filter(.data[[intermediate_id_col]] %in% new_dvobject$cett[[cett_name]][["general_information"]][[intermediate_id_col]]) + if (NROW(filtered_subtable) > 0) { + new_dvobject$references[[cett_name]][[name]] <- filtered_subtable + } + } + } + } + } + } + + # --- Final Step: Preserve original object's attributes --- + #attributes(new_dvobject) <- attributes(dvobject) + message("Subsetting complete.") + new_dvobject +} + + +#' Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) +#' +#' Intelligently filters an OnSIDES dvobject by cascading filters through the +#' relational tables, ensuring the final subset is self-consistent. +#' +#' @param dvobject A dvobject from `parseOnSIDES()`. +#' @param ingredient_ids A character vector of RxNorm CUIs (ingredients) to keep. +#' +#' @return A new, smaller dvobject with the same structure. +#' @noRd +subset_onsides_dvobject <- function(dvobject, ingredient_ids) { + if (length(ingredient_ids) == 0) return(dvobject[0]) + + new_db <- list() + + # --- 1. Get the cascading set of keys --- + message("Subsetting OnSIDES: Identifying all related keys...") + # Find all products containing our target ingredients + relevant_product_ids <- dvobject$vocab_rxnorm_ingredient_to_product %>% + dplyr::filter(ingredient_id %in% ingredient_ids) %>% + dplyr::pull(product_id) %>% + unique() + + # Find all labels associated with those products + relevant_label_ids <- dvobject$product_to_rxnorm %>% + dplyr::filter(rxnorm_product_id %in% relevant_product_ids) %>% + dplyr::pull(label_id) %>% + unique() + + # --- 2. Filter the main data tables --- + message("Filtering main OnSIDES data tables...") + new_db$product_adverse_effect <- dvobject$product_adverse_effect %>% + dplyr::filter(product_label_id %in% relevant_label_ids) + + if ("high_confidence" %in% names(dvobject)) { + new_db$high_confidence <- dvobject$high_confidence %>% + dplyr::filter(ingredient_id %in% ingredient_ids) + } + + # --- 3. Filter the "bridge" and vocabulary tables to keep the subset lean --- + message("Filtering vocabulary and mapping tables...") + new_db$product_label <- dvobject$product_label %>% + dplyr::filter(label_id %in% relevant_label_ids) + new_db$product_to_rxnorm <- dvobject$product_to_rxnorm %>% + dplyr::filter(label_id %in% relevant_label_ids) + new_db$vocab_rxnorm_ingredient_to_product <- dvobject$vocab_rxnorm_ingredient_to_product %>% + dplyr::filter(ingredient_id %in% ingredient_ids) + + # Find all MedDRA effects that are actually present in our subset + relevant_meddra_ids <- new_db$product_adverse_effect$effect_meddra_id %>% unique() + + new_db$vocab_meddra_adverse_effect <- dvobject$vocab_meddra_adverse_effect %>% + dplyr::filter(meddra_id %in% relevant_meddra_ids) + new_db$vocab_rxnorm_ingredient <- dvobject$vocab_rxnorm_ingredient %>% + dplyr::filter(rxnorm_id %in% ingredient_ids) + new_db$vocab_rxnorm_product <- dvobject$vocab_rxnorm_product %>% + dplyr::filter(rxnorm_id %in% relevant_product_ids) + + # Preserve attributes and return + attributes(new_db) <- attributes(dvobject) + return(new_db) +} diff --git a/man/add_database_info.Rd b/man/add_database_info.Rd index 87598b7..9bee2d3 100644 --- a/man/add_database_info.Rd +++ b/man/add_database_info.Rd @@ -26,4 +26,3 @@ dvobject add_database_info Assign passed databases db metadata to passed dvobject } -\keyword{internal} diff --git a/man/subset_drugbank_dvobject.Rd b/man/subset_drugbank_dvobject.Rd new file mode 100644 index 0000000..821a5f2 --- /dev/null +++ b/man/subset_drugbank_dvobject.Rd @@ -0,0 +1,31 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/utils.R +\name{subset_drugbank_dvobject} +\alias{subset_drugbank_dvobject} +\title{Subset a DrugBank dvobject by a vector of DrugBank IDs} +\usage{ +subset_drugbank_dvobject(dvobject, drug_ids) +} +\arguments{ +\item{dvobject}{The dvobject from `parseDrugBank()`.} + +\item{drug_ids}{A character vector of `drugbank_id` values to keep.} +} +\value{ +A new, smaller dvobject with the same structure and attributes. +} +\description{ +Subset a DrugBank dvobject by a vector of DrugBank IDs +} +\details{ +Intelligently filters a DrugBank dvobject to retain only the data associated +with a specified list of drugbank_ids. It correctly handles the deep, +multi-level nested structure of the entire object, including the complex +relationships within the `cett` list. +} +\examples{ +\dontrun{ +one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, + drug_ids = "DB00001") +} +} diff --git a/vignettes/drugbank_nside.Rmd b/vignettes/drugbank_nside.Rmd new file mode 100644 index 0000000..b6f85a8 --- /dev/null +++ b/vignettes/drugbank_nside.Rmd @@ -0,0 +1,109 @@ +--- +title: "Integrating DrugBank and OnSIDES for Pharmacovigilance Analysis" +output: rmarkdown::html_vignette +vignette: > + %\VignetteIndexEntry{Integrating DrugBank and OnSIDES for Pharmacovigilance Analysis} + %\VignetteEngine{knitr::rmarkdown} + %\VignetteEncoding{UTF-8} +--- + +```{r, include = FALSE} +knitr::opts_chunk$set( + collapse = TRUE, + comment = "#>", + warning = FALSE, + message = FALSE +) +``` + +## Introduction + +This vignette demonstrates how to use the `merge_drugbank_onsides()` function to create a powerful, integrated dataset for pharmacovigilance research. By combining the deep mechanistic data from **DrugBank** with the large-scale, real-world side effect data from **OnSIDES**, we can perform sophisticated analyses that would otherwise be impossible. + +Our use case: **Identify the most common high-confidence side effects for Statins and visualize the results.** + +```{r setup} +library(dbparser) +library(dplyr) +library(ggplot2) +library(plotly) +library(DT) +``` + +## Step 1: Loading and Merging the Data + +We begin with pre-parsed `dvobject`s for DrugBank and OnSIDES. The `merge_drugbank_onsides()` function combines them into a single, well-organized object. + +```{r merge-data, eval=FALSE} +# In a real analysis: +# drugbank_db <- parseDrugBank("path/to/drugbank.xml") +# onsides_db <- parseOnSIDES("path/to/onsides_csvs/") +# +# For this vignette, we use example data: +drugbank_db <- dbparser::drugbank_example +onsides_db <- dbparser::onsides_example + +merged_db <- merge_drugbank_onsides(drugbank_db, onsides_db) +``` +```{r, echo=FALSE} +# Create mock merged data for the vignette to run +# This code block would not be in the final vignette, it's just for compilation +mock_drugbank_db <- structure(list(drugs = list(drugs = data.frame(drugbank_id = c("DB00175", "DB01076"), name = c("Simvastatin", "Rosuvastatin")), categories = data.frame(drugbank_id = c("DB00175", "DB01076"), category = "Statins"))), version = "5.1.9") +mock_onsides_db <- structure(list(high_confidence = data.frame(ingredient_id = c("12345"), effect_meddra_id = c(101, 102, 103)), vocab_meddra_adverse_effect = data.frame(meddra_id = c(101, 102, 103), meddra_name = c("Myalgia", "Headache", "Nausea"))), version = "2.0") +mock_rxcui_map <- data.frame(drugbank_id = c("DB00175", "DB01076"), rxcui = c("12345", "67890")) +mock_enriched_hc <- data.frame(drugbank_id = c("DB00175", "DB01076", "DB00175"), drug_name = c("Simvastatin", "Rosuvastatin", "Simvastatin"), meddra_name = c("Myalgia", "Myalgia", "Headache")) +merged_db <- list(drugbank = mock_drugbank_db, onsides = mock_onsides_db, integrated_data = list(drugbank_onsides_mapping = mock_rxcui_map, high_confidence = mock_enriched_hc)) +``` + +The resulting `merged_db` object has a clean, nested structure: +- `merged_db$drugbank`: Contains the original DrugBank data. +- `merged_db$onsides`: Contains the original OnSIDES data. +- `merged_db$integrated_data`: Contains new, enriched tables that link the two. +- `merged_db$metadata`: Contains detailed, per-database metadata. + +## Step 2: Use Case - Analyzing Statin Side Effects + +### 2.1 Identifying Statins + +We access the `categories` table inside the `drugbank` list to find all drugs classified as "Statins". + +```{r find-statins} +# Note the nested path: merged_db$drugbank$drugs$categories +anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% + filter(category == "Anticoagulants") %>% + pull(drugbank_id) + + +anticoagulant_drugs <- merged_db$drugbank$drugs$general_information %>% + filter(drugbank_id %in% anticoagulant_ids) + +datatable( + anticoagulant_drugs %>% select(drugbank_id, name), + caption = "Anticoagulants Found in DrugBank" +) +``` + +### 2.2 Finding and Visualizing Common Side Effects + +Now, we can filter our `high_confidence` table from the `integrated_data` list to find the side effects associated with these anticoagulants and count their occurrences. + +```{r count-effects} +anticoagulant_side_effects <- merged_db$integrated_data$high_confidence_enriched %>% + filter(drugbank_id %in% anticoagulant_ids) %>% + count(effect_meddra_id, sort = TRUE, name = "Frequency") %>% + filter(!is.na(effect_meddra_id)) # Remove any potential NA values + +# Display the results in an interactive table +datatable( + anticoagulant_side_effects, + options = list(pageLength = 10), + caption = "Table 1: High-Confidence Side Effects Associated with Anticoagulants" +) +``` + +The plot clearly shows "Myalgia" (muscle pain) as the most frequent high-confidence side effect, which is clinically well-established for statins and validates our integrated data. + +## Conclusion + +The `merge_drugbank_onsides` function, respecting the scalable `dvobject` structure, allows for clear and powerful integration of disparate datasets. By maintaining distinct namespaces for each database (`$drugbank`, `$onsides`) and providing a dedicated list for `integrated_data`, the final object is both easy to navigate and ready for complex, multi-database analyses. + From a9a2ecdc8db904b569a605a34bb310d41f85d6db Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 30 Nov 2025 07:31:35 +0200 Subject: [PATCH 16/57] #177, add drugbank subset function unit tests and added few fixes --- R/utils.R | 93 ++++++++++++++++++-------------- inst/two_drugs.RDS | Bin 0 -> 230686 bytes man/subset_drugbank_dvobject.Rd | 2 + tests/testthat/test_utils.R | 24 +++++++++ 4 files changed, 78 insertions(+), 41 deletions(-) create mode 100644 inst/two_drugs.RDS create mode 100644 tests/testthat/test_utils.R diff --git a/R/utils.R b/R/utils.R index 1bbea59..68fb9cc 100644 --- a/R/utils.R +++ b/R/utils.R @@ -1,8 +1,15 @@ -# Create a reusable helper function to process one component (carrier, enzyme, etc.) +#' Create a reusable helper function to process one component (carrier, enzyme, etc.) +#' @param component the component to subset from CETT +#' @param component_name componemt name +#' @param drug_ids passed drugs ids to subset for +#' +#' @return A new, smaller dvobject with the same structure. +#' @noRd +#' @keywords internal subset_cett_component <- function(component, component_name, drug_ids) { new_component <- list() - if (!is.null(component)) { + if (!is.null(component) && (NROW(component$general_information) > 0)) { # The name of the intermediate ID, e.g., "carrier_id", "target_id" intermediate_id_col <- paste0(sub("s$", "", component_name), "_id") @@ -62,13 +69,16 @@ subset_cett_component <- function(component, component_name, drug_ids) { #' one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, #' drug_ids = "DB00001") #' } +#' @family utils subset_drugbank_dvobject <- function(dvobject, drug_ids) { - new_dvobject <- list() + new_dvobject <- NULL - if (length(drug_ids) == 0) { - warning("`drug_ids` is empty. Returning an empty structure.") + if ((length(drug_ids) == 0) || (sum(nchar(drug_ids)) == 0)) { + warning("`drug_ids` is empty. Returning NULL") } else { + new_dvobject <- list() + # --- 1. Filter the `drugs` list (many sub-tables) --- if (!is.null(dvobject$drugs)) { message("Subsetting `drugs` list...") @@ -88,12 +98,12 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { # --- 2. Filter the `salts`, `products` data.frames --- for (name in c("salts", "products")) { - if (!is.null(dvobject[[name]])) { + if (NROW(dvobject[[name]]) > 0) { message(paste("Subsetting", name, "...")) filtered_subtable <- dvobject[[name]] %>% dplyr::filter(drugbank_id %in% drug_ids) if (NROW(filtered_subtable) > 0) { - new_dvobject$drugs[[name]] <- filtered_subtable + new_dvobject[[name]] <- filtered_subtable } } } @@ -113,53 +123,54 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { } } } - } - # --- 4. Filter the complex, multi-level `cett` List --- - if (!is.null(dvobject$cett)) { - message("Subsetting complex `cett` list...") - new_dvobject$cett <- list() + # --- 4. Filter the complex, multi-level `cett` List --- + if (!is.null(dvobject$cett)) { + message("Subsetting complex `cett` list...") + new_dvobject$cett <- list() - # Apply the helper to each component within cett - for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { - component <- subset_cett_component( - component = dvobject$cett[[cett_name]], - component_name = cett_name, - drug_ids = drug_ids) + # Apply the helper to each component within cett + for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { + component <- subset_cett_component( + component = dvobject$cett[[cett_name]], + component_name = cett_name, + drug_ids = drug_ids) - if (length(component) > 0) { - new_dvobject$cett[[cett_name]] <- component + if (length(component) > 0) { + new_dvobject$cett[[cett_name]] <- component + } } } - } - # --- 5. Filter the CETT`references` list --- - if (!is.null(dvobject$references)) { - for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { - if ((length(dvobject$references[[cett_name]]) > 0) && - (length(new_dvobject$cett[[cett_name]]) > 0)) { - message("Subsetting ", cett_name ," references list...") - cett_references <- list() - # The name of the intermediate ID, e.g., "carrier_id", "target_id" - intermediate_id_col <- paste0(sub("s$", "", cett_name), "_id") - - for (name in names(dvobject$references[[cett_name]])) { - sub_table <- dvobject$references[[cett_name]][[name]] - if (is.data.frame(sub_table) && (intermediate_id_col %in% names(sub_table))) { - filtered_subtable <- sub_table %>% - dplyr::filter(.data[[intermediate_id_col]] %in% new_dvobject$cett[[cett_name]][["general_information"]][[intermediate_id_col]]) - if (NROW(filtered_subtable) > 0) { - new_dvobject$references[[cett_name]][[name]] <- filtered_subtable + # --- 5. Filter the CETT`references` list --- + if (!is.null(dvobject$references)) { + for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { + if ((length(dvobject$references[[cett_name]]) > 0) && + (length(new_dvobject$cett[[cett_name]]) > 0)) { + message("Subsetting ", cett_name ," references list...") + cett_references <- list() + # The name of the intermediate ID, e.g., "carrier_id", "target_id" + intermediate_id_col <- paste0(sub("s$", "", cett_name), "_id") + + for (name in names(dvobject$references[[cett_name]])) { + sub_table <- dvobject$references[[cett_name]][[name]] + if (is.data.frame(sub_table) && (intermediate_id_col %in% names(sub_table))) { + filtered_subtable <- sub_table %>% + dplyr::filter(.data[[intermediate_id_col]] %in% new_dvobject$cett[[cett_name]][["general_information"]][[intermediate_id_col]]) + if (NROW(filtered_subtable) > 0) { + new_dvobject$references[[cett_name]][[name]] <- filtered_subtable + } } } } } } + + # --- Final Step: Preserve original 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- Added object metadata --- R/utils.R | 5 ++++- inst/two_drugs.RDS | Bin 230686 -> 230769 bytes 2 files changed, 4 insertions(+), 1 deletion(-) diff --git a/R/utils.R b/R/utils.R index 68fb9cc..6f3d8f8 100644 --- a/R/utils.R +++ b/R/utils.R @@ -77,7 +77,7 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { if ((length(drug_ids) == 0) || (sum(nchar(drug_ids)) == 0)) { warning("`drug_ids` is empty. Returning NULL") } else { - new_dvobject <- list() + new_dvobject <- init_dvobject() # --- 1. Filter the `drugs` list (many sub-tables) --- if (!is.null(dvobject$drugs)) { @@ -166,6 +166,9 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { } } + attr(new_dvobject, "original_db_info") <- attr(dvobject, "original_db_info") + class(dvobject) <- "dvobject" + # --- Final Step: Preserve original object's attributes --- #attributes(new_dvobject) <- attributes(dvobject) message("Subsetting complete.") diff --git a/inst/two_drugs.RDS b/inst/two_drugs.RDS index ed48c275bb5d22bd05dddc23b9d7fef4b63c8eca..36dad7fdd933f75db13c1b541764985af26707df 100644 GIT binary patch delta 228446 zcmV)3K+C_LiVpFL4v?aM26dlc;n8=$i~oKel|O+0eF*>i?xS}eZNR^e_xJMfUsW#Z z#fsAEa(KPtZO z4VYzV1IOYo~sa z3{4vvTAX>N-P8JxJ8*2SJv*{5Uq0W}zOpUzHP@g^joTfk$89I@v<^2|+$lEP(X4bD zhGYB8w8dngON(oN`#Cl+ZAW8<+0mZu=b*7MvYuq8rF z_ZN*qzE~&}eyKHZf;f5ja9|o_2>?l0AZuF!RBhAl;ONkQF~UK7<8lMm@3lo^=)}afaa!mjg^fz>D&%~8? zVRg7(!!m7u=+@GB7rQq`*q;n6TkDwD-1WrPcT5}-dWTK40s%MHxn{NjD}XONANB-* 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zQwJnbwUTiBQv&+!fet@nOq+}%oV<~LfDKSq!^wVr;B~U!2QWuPtiZnWr?+eybO3t% zuzx?)x)~Mr0K~T5o?pP5vuj0DF7XUKrAyF`c%|F`DY+Rzsh!9M{|7fem(}?Y+HQ97 zp6~6+?|a{RzB7itPuRYVWcjkNO0qDRRaw@Gm(^;$c&TMXeQ{aadAC~M%ksmF`UkPnr6~g=%K|43LFQ(|>uCEcSAJ?ZL*kH2U~|UXS|uG9CSyl=C+t zNWS{UZz)yuZL&_^zEIyt>38ku&*Vrn$KOJnE!XoI9i0tZkDct`)CqJPvv^wQR&_V%^JqRtpz`I6kjVICThP35VqPjOR7z>>@v{MxEX6u$W?_BKK zz7?o~22ead>9!X0XOeCalMHV;(N!e=bB13Z6!jdNFT{s9X_dSvilueS8+WeU!&@@Q z$-l333O_G8n@l3&;n6O^`jwd-_>iBF^moq3{l(q9#+yTLzXjLwM%{sWn16`Rz*6ym zhy@<&aQM7j_)};|28qu3F28q%sUcfmn?#ta>z!pbSRp@ From 8b1136fd4b2918c10894cfcb949f7172f982ab6e Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 30 Nov 2025 08:08:57 +0200 Subject: [PATCH 18/57] #177, Added subset dvobject metadata unit tests --- tests/testthat/_snaps/utils.md | 48 ++++++++++++++++++++++++++++++++++ tests/testthat/test_utils.R | 10 ++++--- 2 files changed, 54 insertions(+), 4 deletions(-) create mode 100644 tests/testthat/_snaps/utils.md diff --git a/tests/testthat/_snaps/utils.md b/tests/testthat/_snaps/utils.md new file mode 100644 index 0000000..fc2b527 --- /dev/null +++ b/tests/testthat/_snaps/utils.md @@ -0,0 +1,48 @@ +# Read dvobject metadata + + Code + show_dvobject_metadata(new_dvobj) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 32 3 547.6 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original DrugBank 5.1 2025-01-02 + + === DATA.FRAMES === + Path Rows Cols Size + drugs$general_information 1 15 4.8 Kb + drugs$drug_classification 1 9 2.6 Kb + drugs$synonyms 4 4 2 Kb + drugs$pharmacology 1 12 9 Kb + drugs$international_brands 6 3 2 Kb + drugs$mixtures 4 3 1.7 Kb + drugs$packagers 11 3 3.1 Kb + drugs$prices 7 5 2.9 Kb + drugs$categories 28 3 5.1 Kb + drugs$dosages 129 4 12.2 Kb + drugs$atc_codes 2 10 2.9 Kb + drugs$patents 32 6 7.9 Kb + drugs$drug_interactions 1194 4 387.1 Kb + drugs$sequences 1 3 1.3 Kb + drugs$experimental_properties 2 4 1.7 Kb + drugs$external_identifiers 13 3 3.1 Kb + drugs$affected_organisms 1 2 1.1 Kb + drugs$groups 2 2 1.2 Kb + drugs$external_links 2 3 1.5 Kb + salts 2 8 2.8 Kb + products 81 19 33.6 Kb + references$drugs$articles 4 4 2.8 Kb + references$drugs$links 9 4 5.3 Kb + references$targets$articles 55 4 17.2 Kb + references$targets$links 14 4 7.1 Kb + cett$targets$general_information 2 6 2.1 Kb + cett$targets$actions 6 2 1.6 Kb + cett$targets$polypeptides$general_information 2 20 8.1 Kb + cett$targets$polypeptides$external_identy 13 3 2.9 Kb + cett$targets$polypeptides$synonyms 7 2 1.6 Kb + cett$targets$polypeptides$pfams 2 3 1.5 Kb + cett$targets$polypeptides$go 3 3 1.6 Kb + diff --git a/tests/testthat/test_utils.R b/tests/testthat/test_utils.R index 869d575..a98ecfa 100644 --- a/tests/testthat/test_utils.R +++ b/tests/testthat/test_utils.R @@ -1,18 +1,19 @@ context("test utils functions") library(testthat) +local_edition(3) -biotech <- "drugbank_record_biotech.xml" test_that( desc = "Read dvobject metadata", code = { dvobj <- readRDS(system.file("two_drugs.RDS", package = "dbparser")) - new_dvobj <- testthat::expect_warning( - subset_drugbank_dvobject(dvobject = dvobj, - drug_ids = ""), + expect_warning( + new_dvobj <- subset_drugbank_dvobject(dvobject = dvobj, + drug_ids = ""), "`drug_ids` is empty. Returning NULL") + expect_equal(length(new_dvobj), 0) new_dvobj <- subset_drugbank_dvobject(dvobject = dvobj, @@ -20,5 +21,6 @@ test_that( expect_equal(length(new_dvobj), 5) expect_equal(NROW(new_dvobj$drugs$general_information), 1) expect_equal(length(new_dvobj$cett), 1) + expect_snapshot(show_dvobject_metadata(new_dvobj)) } ) From cc1333193e496065b68fdc493a586c35efdbf064 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 30 Nov 2025 15:20:24 +0200 Subject: [PATCH 19/57] #177, added onside subset function --- NAMESPACE | 2 + R/merge_helpers.R | 2 +- R/utils.R | 144 +++++++++++++++++++++----------- inst/onside.RDS | Bin 0 -> 189824 bytes man/subset_drugbank_dvobject.Rd | 4 + man/subset_onsides_dvobject.Rd | 25 ++++++ 6 files changed, 126 insertions(+), 51 deletions(-) create mode 100644 inst/onside.RDS create mode 100644 man/subset_onsides_dvobject.Rd diff --git a/NAMESPACE b/NAMESPACE index 62809af..a85bf8e 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -9,6 +9,7 @@ export(parseOnSIDES) export(references_node_options) export(show_dvobject_metadata) export(subset_drugbank_dvobject) +export(subset_onsides_dvobject) import(dplyr) importFrom(XML,xmlApply) importFrom(XML,xmlChildren) @@ -25,6 +26,7 @@ importFrom(dplyr,.data) importFrom(dplyr,filter) importFrom(dplyr,left_join) importFrom(dplyr,mutate) +importFrom(dplyr,pull) importFrom(dplyr,rename) importFrom(dplyr,select) importFrom(progress,progress_bar) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 18b38da..55aa340 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -74,7 +74,7 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { message("Creating DrugBank ID <-> RxCUI mapping table...") rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% dplyr::filter(.data$resource == "RxCUI") %>% - dplyr::select(.data$drugbank_id, rxcui = .data$identifier) + dplyr::select(all_of(drugbank_id), rxcui = .data$identifier) # --- Step 2: Enrich OnSIDES Tables --- message("Enriching OnSIDES tables with DrugBank IDs...") diff --git a/R/utils.R b/R/utils.R index 6f3d8f8..870b5eb 100644 --- a/R/utils.R +++ b/R/utils.R @@ -71,7 +71,6 @@ subset_cett_component <- function(component, component_name, drug_ids) { #' } #' @family utils subset_drugbank_dvobject <- function(dvobject, drug_ids) { - new_dvobject <- NULL if ((length(drug_ids) == 0) || (sum(nchar(drug_ids)) == 0)) { @@ -167,7 +166,7 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { } attr(new_dvobject, "original_db_info") <- attr(dvobject, "original_db_info") - class(dvobject) <- "dvobject" + class(new_dvobject) <- "dvobject" # --- Final Step: Preserve original object's attributes --- #attributes(new_dvobject) <- attributes(dvobject) @@ -186,57 +185,102 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { #' @param dvobject A dvobject from `parseOnSIDES()`. #' @param ingredient_ids A character vector of RxNorm CUIs (ingredients) to keep. #' +#' @export +#' @importFrom dplyr .data filter pull +#' #' @return A new, smaller dvobject with the same structure. -#' @noRd +#' @family utils subset_onsides_dvobject <- function(dvobject, ingredient_ids) { - if (length(ingredient_ids) == 0) return(dvobject[0]) - - new_db <- list() - - # --- 1. Get the cascading set of keys --- - message("Subsetting OnSIDES: Identifying all related keys...") - # Find all products containing our target ingredients - relevant_product_ids <- dvobject$vocab_rxnorm_ingredient_to_product %>% - dplyr::filter(ingredient_id %in% ingredient_ids) %>% - dplyr::pull(product_id) %>% - unique() - - # Find all labels associated with those products - relevant_label_ids <- dvobject$product_to_rxnorm %>% - dplyr::filter(rxnorm_product_id %in% relevant_product_ids) %>% - dplyr::pull(label_id) %>% - unique() - - # --- 2. Filter the main data tables --- - message("Filtering main OnSIDES data tables...") - new_db$product_adverse_effect <- dvobject$product_adverse_effect %>% - dplyr::filter(product_label_id %in% relevant_label_ids) - - if ("high_confidence" %in% names(dvobject)) { - new_db$high_confidence <- dvobject$high_confidence %>% + new_dvobject <- NULL + + if ((length(ingredient_ids) == 0) || (sum(nchar(ingredient_ids)) == 0)) { + warning("`ingredient_ids` is empty. Returning NULL") + } else { + new_dvobject <- init_dvobject() + + # --- 1. Get the cascading set of keys --- + message("Subsetting OnSIDES: Identifying all related keys...") + # Find all products containing our target ingredients + relevant_product_ids <- dvobject$vocab_rxnorm_ingredient_to_product %>% + dplyr::filter(ingredient_id %in% ingredient_ids) %>% + dplyr::pull(product_id) %>% + unique() + + # Find all labels associated with those products + relevant_label_ids <- dvobject$product_to_rxnorm %>% + dplyr::filter(rxnorm_product_id %in% relevant_product_ids) %>% + dplyr::pull(label_id) %>% + unique() + + # --- 2. Filter the main data tables --- + message("Filtering main OnSIDES data tables...") + product_adverse_effect <- dvobject$product_adverse_effect %>% + dplyr::filter(product_label_id %in% relevant_label_ids) + + if (NROW(product_adverse_effect) > 0) { + new_dvobject$product_adverse_effect <- product_adverse_effect + } + + if ("high_confidence" %in% names(dvobject)) { + high_confidence <- dvobject$high_confidence %>% + dplyr::filter(ingredient_id %in% ingredient_ids) + + if (NROW(high_confidence) > 0) { + new_dvobject$high_confidence <- high_confidence + } + } + + # --- 3. Filter the "bridge" and vocabulary tables to keep the subset lean --- + message("Filtering vocabulary and mapping tables...") + product_label <- dvobject$product_label %>% + dplyr::filter(label_id %in% relevant_label_ids) + + if (NROW(product_label) > 0) { + new_dvobject$product_label <- product_label + } + + product_to_rxnorm <- dvobject$product_to_rxnorm %>% + dplyr::filter(label_id %in% relevant_label_ids) + + if (NROW(product_to_rxnorm) > 0) { + new_dvobject$product_to_rxnorm <- product_to_rxnorm + } + + vocab_rxnorm_ingredient_to_product <- dvobject$vocab_rxnorm_ingredient_to_product %>% dplyr::filter(ingredient_id %in% ingredient_ids) + + if (NROW(vocab_rxnorm_ingredient_to_product) > 0) { + new_dvobject$vocab_rxnorm_ingredient_to_product <- vocab_rxnorm_ingredient_to_product + } + + # Find all MedDRA effects that are actually present in our subset + relevant_meddra_ids <- new_dvobject$product_adverse_effect$effect_meddra_id %>% unique() + + vocab_meddra_adverse_effect <- dvobject$vocab_meddra_adverse_effect %>% + dplyr::filter(meddra_id %in% relevant_meddra_ids) + + if (NROW(vocab_meddra_adverse_effect) > 0) { + new_dvobject$vocab_meddra_adverse_effect <- vocab_meddra_adverse_effect + } + + vocab_rxnorm_ingredient <- dvobject$vocab_rxnorm_ingredient %>% + dplyr::filter(rxnorm_id %in% ingredient_ids) + + if (NROW(vocab_rxnorm_ingredient) > 0) { + new_dvobject$vocab_rxnorm_ingredient <- vocab_rxnorm_ingredient + } + + vocab_rxnorm_product <- dvobject$vocab_rxnorm_product %>% + dplyr::filter(rxnorm_id %in% relevant_product_ids) + + if (NROW(vocab_rxnorm_product) > 0) { + new_dvobject$vocab_rxnorm_product <- vocab_rxnorm_product + } + + # Preserve attributes and return + attr(new_dvobject, "original_db_info") <- attr(dvobject, "original_db_info") + class(new_dvobject) <- "dvobject" } - # --- 3. Filter the "bridge" and vocabulary tables to keep the subset lean --- - message("Filtering vocabulary and mapping tables...") - new_db$product_label <- dvobject$product_label %>% - dplyr::filter(label_id %in% relevant_label_ids) - new_db$product_to_rxnorm <- dvobject$product_to_rxnorm %>% - dplyr::filter(label_id %in% relevant_label_ids) - new_db$vocab_rxnorm_ingredient_to_product <- dvobject$vocab_rxnorm_ingredient_to_product %>% - dplyr::filter(ingredient_id %in% ingredient_ids) - - # Find all MedDRA effects that are actually present in our subset - relevant_meddra_ids <- new_db$product_adverse_effect$effect_meddra_id %>% unique() - - new_db$vocab_meddra_adverse_effect <- dvobject$vocab_meddra_adverse_effect %>% - dplyr::filter(meddra_id %in% relevant_meddra_ids) - new_db$vocab_rxnorm_ingredient <- dvobject$vocab_rxnorm_ingredient %>% - dplyr::filter(rxnorm_id %in% ingredient_ids) - new_db$vocab_rxnorm_product <- dvobject$vocab_rxnorm_product %>% - dplyr::filter(rxnorm_id %in% relevant_product_ids) - - # Preserve attributes and return - attributes(new_db) <- attributes(dvobject) - return(new_db) + new_dvobject } diff --git a/inst/onside.RDS b/inst/onside.RDS new file mode 100644 index 0000000000000000000000000000000000000000..cbd3118a23df59b4983ee490d63252cca7157590 GIT binary patch literal 189824 zcmeF42|SeR7sqd@RJL~6D@i33*}}NhEtR6>mSjspA!DDxFiBC_iexvpR4SoT4Q3eo z&Ll}8NxBBbze14tzzP!ts*SkE=Ip>iHp83nGe=~YHKJEz~ z91ZWF$2Siem_}6ZqjyD8Dt}f%ByLL&+CaoI@;@fuZty}7G`uU1!?Ed-qr+hgcc8LphCkP&g}yiFlT2;h=|> ztue!)862)zBfX5%QieiZyLOZjvC0M!)oangJF&gVIBff~^-NxR3onSl!ST=xm9%SZ z*}6M+U~vpsnxg~$gwIosoez2)uL+A{>NWe+&Ys3q?WHyGOgvds=p$VOFB6joT{4H6 zq1j*k>ykM$r%m<$6%S44NP|h7))5el&q?GZ8ePIRa_9B%ERJv}06pZI(Vyhzn!%U7 z{0-hh;}gE1W5e#RexCveLW#dx&zse~{x2VaHjoQ@jgl>w(u_2;=& zdCr(hanfMRzCNHOR3{f8HxY!p|K}mTy=y#sbBWi7`0j>ZeWF@=V9vk!t$b*SOW&V+ zkq^xih#1{#gg`iyw53*X^vIZ7-yEto5PQoXdR;YR));Gi<+0UzUdvzYTRti{(&(j& zL9or~qdxUL(JlDlFX5p{!Hqlz3^hC-8m&MYJ;wJBgi0YLa#6u_XpTunuD02Ll6!ui 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b/man/subset_drugbank_dvobject.Rd index 423f09e..e5fd8c6 100644 --- a/man/subset_drugbank_dvobject.Rd +++ b/man/subset_drugbank_dvobject.Rd @@ -30,4 +30,8 @@ one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, drug_ids = "DB00001") } } +\seealso{ +Other utils: +\code{\link{subset_onsides_dvobject}()} +} \concept{utils} diff --git a/man/subset_onsides_dvobject.Rd b/man/subset_onsides_dvobject.Rd new file mode 100644 index 0000000..ebf9063 --- /dev/null +++ b/man/subset_onsides_dvobject.Rd @@ -0,0 +1,25 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/utils.R +\name{subset_onsides_dvobject} +\alias{subset_onsides_dvobject} +\title{Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware)} +\usage{ +subset_onsides_dvobject(dvobject, ingredient_ids) +} +\arguments{ +\item{dvobject}{A dvobject from `parseOnSIDES()`.} + +\item{ingredient_ids}{A character vector of RxNorm CUIs (ingredients) to keep.} +} +\value{ +A new, smaller dvobject with the same structure. +} +\description{ +Intelligently filters an OnSIDES dvobject by cascading filters through the +relational tables, ensuring the final subset is self-consistent. +} +\seealso{ +Other utils: +\code{\link{subset_drugbank_dvobject}()} +} +\concept{utils} From 056ab754309805cf87950692b5435612ddb9e769 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 30 Nov 2025 15:33:58 +0200 Subject: [PATCH 20/57] #177, add onside subset function unit test --- tests/testthat/_snaps/utils.md | 26 +++++++++++++++++++++++++- tests/testthat/test_utils.R | 24 +++++++++++++++++++++++- 2 files changed, 48 insertions(+), 2 deletions(-) diff --git a/tests/testthat/_snaps/utils.md b/tests/testthat/_snaps/utils.md index fc2b527..ba2f20d 100644 --- a/tests/testthat/_snaps/utils.md +++ b/tests/testthat/_snaps/utils.md @@ -1,4 +1,4 @@ -# Read dvobject metadata +# subset_drugbank_dvobject Code show_dvobject_metadata(new_dvobj) @@ -46,3 +46,27 @@ cett$targets$polypeptides$pfams 2 3 1.5 Kb cett$targets$polypeptides$go 3 3 1.6 Kb +# subset_onsides_dvobject + + Code + show_dvobject_metadata(new_dvobj) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 8 0 846.1 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original OnSIDES 3.1.1 April 2025 + + === DATA.FRAMES === + Path Rows Cols Size + product_adverse_effect 18742 7 808 Kb + high_confidence 2 2 1.4 Kb + product_label 29 5 13 Kb + product_to_rxnorm 44 2 2.2 Kb + vocab_rxnorm_ingredient_to_product 3 2 1.6 Kb + vocab_meddra_adverse_effect 139 3 13.9 Kb + vocab_rxnorm_ingredient 1 3 1.8 Kb + vocab_rxnorm_product 3 3 2.2 Kb + diff --git a/tests/testthat/test_utils.R b/tests/testthat/test_utils.R index a98ecfa..fd91579 100644 --- a/tests/testthat/test_utils.R +++ b/tests/testthat/test_utils.R @@ -4,7 +4,7 @@ library(testthat) local_edition(3) test_that( - desc = "Read dvobject metadata", + desc = "subset_drugbank_dvobject", code = { dvobj <- readRDS(system.file("two_drugs.RDS", package = "dbparser")) @@ -24,3 +24,25 @@ test_that( expect_snapshot(show_dvobject_metadata(new_dvobj)) } ) + +test_that( + desc = "subset_onsides_dvobject", + code = { + dvobj <- readRDS(system.file("onside.RDS", + package = "dbparser")) + + expect_warning( + new_dvobj <- subset_onsides_dvobject(dvobject = dvobj, + ingredient_ids = ""), + "`ingredient_ids` is empty. Returning NULL") + + expect_equal(length(new_dvobj), 0) + + new_dvobj <- subset_onsides_dvobject( + dvobject = dvobj, + ingredient_ids = 613391) + expect_equal(length(new_dvobj), 8) + expect_equal(NROW(new_dvobj$high_confidence), 2) + expect_snapshot(show_dvobject_metadata(new_dvobj)) + } +) From 03a3c3972dcb2ac8af862a313ab603e29fb298e7 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 30 Nov 2025 19:29:42 +0200 Subject: [PATCH 21/57] #177, fixed issues and added unit tests --- R/dvobject_metadata.R | 6 +- R/merge_helpers.R | 7 +- inst/onside.zip | Bin 0 -> 142365 bytes tests/testthat/_snaps/merge_functions.md | 83 +++++++++++++++++++++++ tests/testthat/_snaps/onside_parser.md | 29 ++++++++ tests/testthat/test_dvobject_metadata.R | 4 +- tests/testthat/test_merge_functions.R | 34 ++++++++++ tests/testthat/test_onside_parser.R | 15 ++++ 8 files changed, 170 insertions(+), 8 deletions(-) create mode 100644 inst/onside.zip create mode 100644 tests/testthat/_snaps/merge_functions.md create mode 100644 tests/testthat/_snaps/onside_parser.md create mode 100644 tests/testthat/test_merge_functions.R create mode 100644 tests/testthat/test_onside_parser.R diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index d8e3dcd..1ac4e81 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -189,9 +189,9 @@ build_metadata <- function(attrs, has_second_db, second_db_name) { metadata <- rbind( data.frame( Database = "First Database", - Type = attrs$original_db_info$db_type %||% "Unknown", - Version = attrs$original_db_info$db_version %||% "Unknown", - Export_Date = attrs$original_db_info$db_exported_date %||% "Unknown", + Type = attrs$DrugBankDB$db_type %||% "Unknown", + Version = attrs$DrugBankDB$db_version %||% "Unknown", + Export_Date = attrs$DrugBankDB$db_exported_date %||% "Unknown", stringsAsFactors = FALSE ), data.frame( diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 55aa340..f9c6d9e 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -73,8 +73,8 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { # --- Step 1: Create the Bridge (RxCUI Mapping Table) --- message("Creating DrugBank ID <-> RxCUI mapping table...") rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% - dplyr::filter(.data$resource == "RxCUI") %>% - dplyr::select(all_of(drugbank_id), rxcui = .data$identifier) + dplyr::filter(resource == "RxCUI") %>% + dplyr::select(all_of("drugbank_id"), rxcui = identifier) # --- Step 2: Enrich OnSIDES Tables --- message("Enriching OnSIDES tables with DrugBank IDs...") @@ -94,8 +94,9 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { message("Assembling final merged object...") # Start with all of DrugBank's data - merged_object <- list() + merged_object <- init_dvobject() merged_object$drugbank <- drugbank_db + attr(merged_object, "DrugBankDB") <- attr(drugbank_db, "original_db_info") merged_object$onsides <- list() merged_object$integrated_data <- list() diff --git 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z7O;!!u1fKk16}Kl*TwQUTuh1^@dRsPR#sxhLPW48ta|Wz-GlfkGZqU>nlWW^)FNSl zH^)yueg9fMAtxs(C1c&=S<`0D3Saa%WXg=`iyp9>h-P&NPEu@Rd$EkgdiRGSMzGh` zGQ~RQ0lhU9>@`Lv5oQq}i-DmEtuxQgAORK!5&s=QB(!Uf(UWIoV7vkB$p?5t41K zN*-L3;=lA~>u>&NlKWR<2RU?lpX+ Z0NfH*Hegz1-~_@3W(J0K4PcLf0RY2kKSTfk literal 0 HcmV?d00001 diff --git a/tests/testthat/_snaps/merge_functions.md b/tests/testthat/_snaps/merge_functions.md new file mode 100644 index 0000000..1d4850f --- /dev/null +++ b/tests/testthat/_snaps/merge_functions.md @@ -0,0 +1,83 @@ +# merge drugbank and onside + + Code + show_dvobject_metadata(all_dbs) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 DrugBankOnSIDESDb, dvobject 66 3 3.8 Mb + + === DATABASE METADATA === + Database Type Version Export_Date + First Database DrugBank 5.1 2025-01-02 + Second Database OnSIDES 3.1.1 April 2025 + + === DATA.FRAMES === + Path Rows Cols Size + drugbank$drugs$general_information 2 15 8 Kb + drugbank$drugs$drug_classification 2 9 3.8 Kb + drugbank$drugs$synonyms 15 4 3.6 Kb + drugbank$drugs$pharmacology 2 12 18.1 Kb + drugbank$drugs$international_brands 9 3 2.7 Kb + drugbank$drugs$mixtures 5 3 2 Kb + drugbank$drugs$packagers 35 3 6.2 Kb + drugbank$drugs$manufacturers 13 4 2.9 Kb + drugbank$drugs$prices 16 5 4.6 Kb + drugbank$drugs$categories 58 3 9.2 Kb + drugbank$drugs$dosages 189 4 17.4 Kb + drugbank$drugs$atc_codes 4 10 4.3 Kb + drugbank$drugs$patents 35 6 8.6 Kb + drugbank$drugs$drug_interactions 1645 4 514.7 Kb + drugbank$drugs$sequences 1 3 1.3 Kb + drugbank$drugs$calculated_properties 26 4 5.6 Kb + drugbank$drugs$experimental_properties 5 4 2.4 Kb + drugbank$drugs$external_identifiers 30 3 4.7 Kb + drugbank$drugs$pdb_entries 19 2 2.4 Kb + drugbank$drugs$affected_organisms 2 2 1.2 Kb + drugbank$drugs$groups 4 2 1.3 Kb + drugbank$drugs$external_links 5 3 2.1 Kb + drugbank$salts 2 8 2.8 Kb + drugbank$products 190 19 68.6 Kb + drugbank$references$drugs$articles 13 4 6.3 Kb + drugbank$references$drugs$links 11 4 6.1 Kb + drugbank$references$carriers$books 1 4 1.6 Kb + drugbank$references$carriers$articles 15 4 5.4 Kb + drugbank$references$enzymes$books 33 4 8.2 Kb + drugbank$references$enzymes$articles 1573 4 485.5 Kb + drugbank$references$enzymes$links 615 4 164.4 Kb + drugbank$references$enzymes$attachments 55 4 20 Kb + drugbank$references$targets$articles 101 4 27.4 Kb + drugbank$references$targets$links 14 4 7.1 Kb + drugbank$cett$carriers$general_information 1 6 1.9 Kb + drugbank$cett$carriers$actions 2 2 1.2 Kb + drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb + drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb + drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb + drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb + drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb + drugbank$cett$enzymes$general_information 2 8 2.6 Kb + drugbank$cett$enzymes$actions 7 2 1.5 Kb + drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb + drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb + drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb + drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb + drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb + drugbank$cett$targets$general_information 4 6 2.6 Kb + drugbank$cett$targets$actions 10 2 1.9 Kb + drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb + drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb + drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb + drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb + drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb + onsides$product_adverse_effect 52745 7 2.2 Mb + onsides$high_confidence 2 2 1.4 Kb + onsides$product_label 95 5 39.7 Kb + onsides$product_to_rxnorm 160 2 5.5 Kb + onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb + onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb + onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb + onsides$vocab_rxnorm_product 17 3 4.9 Kb + integrated_data$high_confidence_enriched 2 3 1.6 Kb + integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb + vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb + diff --git a/tests/testthat/_snaps/onside_parser.md b/tests/testthat/_snaps/onside_parser.md new file mode 100644 index 0000000..fc76e38 --- /dev/null +++ b/tests/testthat/_snaps/onside_parser.md @@ -0,0 +1,29 @@ +# parse onside DB - default params + + Code + expect_error(parseOnSIDES(dataDir = "data_path")) + +--- + + Code + show_dvobject_metadata(onside) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 8 0 845.6 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original OnSIDES Unknown Unknown + + === DATA.FRAMES === + Path Rows Cols Size + product_label 29 5 13 Kb + product_adverse_effect 18742 7 808 Kb + product_to_rxnorm 44 2 2.2 Kb + vocab_meddra_adverse_effect 139 3 13.9 Kb + vocab_rxnorm_ingredient 1 3 1.7 Kb + vocab_rxnorm_product 3 3 2.2 Kb + vocab_rxnorm_ingredient_to_product 3 2 1.6 Kb + high_confidence 2 2 1.4 Kb + diff --git a/tests/testthat/test_dvobject_metadata.R b/tests/testthat/test_dvobject_metadata.R index d5d9afd..3489080 100644 --- a/tests/testthat/test_dvobject_metadata.R +++ b/tests/testthat/test_dvobject_metadata.R @@ -19,8 +19,8 @@ test_that( biotech, package = "dbparser") - dvobj <- parseDrugBank(db_location) - metadata <- dbparser::show_dvobject_metadata(dvobj) + dvobj <- parseDrugBank(db_location) + capture_output(metadata <- dbparser::show_dvobject_metadata(dvobj)) expect_match(metadata$Database, "Original") expect_match(metadata$Type, "DrugBank") diff --git a/tests/testthat/test_merge_functions.R b/tests/testthat/test_merge_functions.R new file mode 100644 index 0000000..e95550d --- /dev/null +++ b/tests/testthat/test_merge_functions.R @@ -0,0 +1,34 @@ +context("test different merge functions") + +test_that( + desc = "merge drugbank and onside", + code = { + local_edition(3) + drugbank <- readRDS(system.file("two_drugs.RDS", + package = "dbparser")) + onside <- readRDS(system.file("onside.RDS", + package = "dbparser")) + expect_error(merge_drugbank_onsides( + drugbank_db = list(), + onsides_db = onside), + "`drugbank_db` must be a valid dvobject from parseDrugBank().") + + invalid_drugbank <- drugbank + invalid_drugbank$drugs$external_identifiers <- NULL + expect_error(merge_drugbank_onsides( + drugbank_db = invalid_drugbank, + onsides_db = onside), + "`drugbank_db` dvobject must contain external_identifiers data.") + + expect_error(merge_drugbank_onsides( + drugbank_db = drugbank, + onsides_db = list()), + "`onsides_db` must be a valid dvobject from parseOnSIDES().") + + all_dbs <- merge_drugbank_onsides( + drugbank_db = drugbank, + onsides_db = onside) + expect_snapshot(show_dvobject_metadata(all_dbs)) + + } +) diff --git a/tests/testthat/test_onside_parser.R b/tests/testthat/test_onside_parser.R new file mode 100644 index 0000000..4378320 --- /dev/null +++ b/tests/testthat/test_onside_parser.R @@ -0,0 +1,15 @@ +context("test parse onside nodes") + +test_that( + desc = "parse onside DB - default params", + code = { + local_edition(3) + expect_snapshot(expect_error(parseOnSIDES(dataDir = "data_path"))) + data_path <- dirname(unzip(system.file("onside.zip", + package = "dbparser"))[1]) + onside <- parseOnSIDES(dataDir = data_path) + unlink(data_path, recursive = TRUE) + expect_equal(length(onside), 8) + expect_snapshot(show_dvobject_metadata(onside)) + } +) From 5f3d210ebda8b21c1087a05ee5b0e25ea644e16c Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 6 Dec 2025 19:26:25 +0200 Subject: [PATCH 22/57] #177, Added drugbank onside tutorial --- vignettes/drugbank_nside.Rmd | 379 ++++++++++++++++++++++++++++++----- 1 file changed, 325 insertions(+), 54 deletions(-) diff --git a/vignettes/drugbank_nside.Rmd b/vignettes/drugbank_nside.Rmd index b6f85a8..9ef620c 100644 --- a/vignettes/drugbank_nside.Rmd +++ b/vignettes/drugbank_nside.Rmd @@ -1,5 +1,5 @@ --- -title: "Integrating DrugBank and OnSIDES for Pharmacovigilance Analysis" +title: "Integrating DrugBank and OnSIDES with dbparser for Pharmacovigilance Analysis" output: rmarkdown::html_vignette vignette: > %\VignetteIndexEntry{Integrating DrugBank and OnSIDES for Pharmacovigilance Analysis} @@ -18,92 +18,363 @@ knitr::opts_chunk$set( ## Introduction -This vignette demonstrates how to use the `merge_drugbank_onsides()` function to create a powerful, integrated dataset for pharmacovigilance research. By combining the deep mechanistic data from **DrugBank** with the large-scale, real-world side effect data from **OnSIDES**, we can perform sophisticated analyses that would otherwise be impossible. +In modern pharmacovigilance, the ability to link a drug's molecular mechanism of action with real-world adverse event data is crucial. **DrugBank** provides rich data on drug targets, enzymes, and pathways, while **OnSIDES** provides a massive database of adverse drug events extracted from FDA drug labels. -Our use case: **Identify the most common high-confidence side effects for Statins and visualize the results.** +The `dbparser` package now bridges these two worlds. This vignette demonstrates how to use the new `merge_drugbank_onsides()` function to create an integrated dataset, using the `show_dvobject_metadata()` function to inspect the data structure at every step. + +We will perform a scientific case study on **Leuprolide**, linking its biological target to its reported real-world side effects. + +## Prerequisites ```{r setup} library(dbparser) library(dplyr) -library(ggplot2) -library(plotly) -library(DT) +library(tidyr) +library(canvasXpress) +library(data.table) ``` -## Step 1: Loading and Merging the Data +## 1. Loading and Inspecting Data + +To demonstrate the functionality, we will use the curated sample data files included in the dbparser package. -We begin with pre-parsed `dvobject`s for DrugBank and OnSIDES. The `merge_drugbank_onsides()` function combines them into a single, well-organized object. +### 1.1 Load DrugBank Data +First, we load the DrugBank sample (two_drugs.RDS) and inspect its metadata to verify the presence of mechanistic data (targets, enzymes, etc.). -```{r merge-data, eval=FALSE} +```{r load_drugbank} # In a real analysis: # drugbank_db <- parseDrugBank("path/to/drugbank.xml") -# onsides_db <- parseOnSIDES("path/to/onsides_csvs/") # -# For this vignette, we use example data: -drugbank_db <- dbparser::drugbank_example -onsides_db <- dbparser::onsides_example +# Load sample DrugBank data included in the package +drugbank_path <- system.file("two_drugs.RDS", package = "dbparser") +drugbank_db <- readRDS(drugbank_path) + +# Review the drugbank object structure +show_dvobject_metadata(drugbank_db) +``` + +### 1.2 Load OnSIDES Data + +Next, we load the OnSIDES sample (onside.RDS). This contains the raw label and adverse effect tables. + +```{r load_onside} +# onsides_db <- parseOnSIDES("path/to/onsides_csvs/") +# Load sample OnSIDES data included in the package +onsides_path <- system.file("onside.RDS", package = "dbparser") +onsides_db <- readRDS(onsides_path) + +# Review the onsides_db object structure +show_dvobject_metadata(onsides_db) +``` + + +## 2. Merging the Databases + +We now use `merge_drugbank_onsides()` to fuse these two objects. This function automatically generates a mapping layer (using RxNorm CUIs) to link DrugBank IDs to OnSIDES label IDs. + +```{r merging_dbs} +# Create the merged database object merged_db <- merge_drugbank_onsides(drugbank_db, onsides_db) + +# Review merged_db object using 'show_dvobject_metadata' method +# Note the appearance of 'integrated_data' and 'vocab_rxnorm_ingredients' +show_dvobject_metadata(merged_db) ``` -```{r, echo=FALSE} -# Create mock merged data for the vignette to run -# This code block would not be in the final vignette, it's just for compilation -mock_drugbank_db <- structure(list(drugs = list(drugs = data.frame(drugbank_id = c("DB00175", "DB01076"), name = c("Simvastatin", "Rosuvastatin")), categories = data.frame(drugbank_id = c("DB00175", "DB01076"), category = "Statins"))), version = "5.1.9") -mock_onsides_db <- structure(list(high_confidence = data.frame(ingredient_id = c("12345"), effect_meddra_id = c(101, 102, 103)), vocab_meddra_adverse_effect = data.frame(meddra_id = c(101, 102, 103), meddra_name = c("Myalgia", "Headache", "Nausea"))), version = "2.0") -mock_rxcui_map <- data.frame(drugbank_id = c("DB00175", "DB01076"), rxcui = c("12345", "67890")) -mock_enriched_hc <- data.frame(drugbank_id = c("DB00175", "DB01076", "DB00175"), drug_name = c("Simvastatin", "Rosuvastatin", "Simvastatin"), meddra_name = c("Myalgia", "Myalgia", "Headache")) -merged_db <- list(drugbank = mock_drugbank_db, onsides = mock_onsides_db, integrated_data = list(drugbank_onsides_mapping = mock_rxcui_map, high_confidence = mock_enriched_hc)) + +> Note: The `integrated_data` slot contains the `DrugBank_RxCUI_Mapping` table, which acts as the "bridge" allowing us to cross from biological mechanisms to clinical side effects. + +## 3. Scientific Case Study: Leuprolide (DB00007) + +**Scientific Context:** Leuprolide is a synthetic analog of gonadotropin-releasing hormone (GnRH). We want to extract its real-world adverse events from OnSIDES and correlate them with its identification in DrugBank. + +### 3.1 Retrieve the Cross-Reference Key +We start by finding the link between the DrugBank ID (`DB00007`) and the RxNorm ID required to search the OnSIDES tables + +```{r find_link} +target_drug_id <- "DB00007" # Leuprolide + +# Access the mapping generated by the merge function +mapping_df <- merged_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id) + +target_rxcui <- mapping_df$rxcui[1] + +print(paste0("DrugBank ID: ", target_drug_id, " maps to RxNorm CUI: ", target_rxcui)) ``` -The resulting `merged_db` object has a clean, nested structure: -- `merged_db$drugbank`: Contains the original DrugBank data. -- `merged_db$onsides`: Contains the original OnSIDES data. -- `merged_db$integrated_data`: Contains new, enriched tables that link the two. -- `merged_db$metadata`: Contains detailed, per-database metadata. +### 3.2 Extract Adverse Events + +Using the retrieved RxCUI, we query the onsides slot of our merged object to find relevant labels and aggregate side effects. + +```{r adverse_events} +# 1. Get the ingredient name from vocab_rxnorm_ingredients +ingredient_name <- merged_db$vocab_rxnorm_ingredient_enriched %>% + filter(rxnorm_id == target_rxcui) %>% + pull(rxnorm_name) + +print(paste("Ingredient name:", ingredient_name)) + +# 2. Find product RxCUIs that contain this ingredient (by name matching) +product_rxcuis <- merged_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui) %>% + pull(product_id) -## Step 2: Use Case - Analyzing Statin Side Effects +print(paste("Found", length(product_rxcuis), "product formulations")) -### 2.1 Identifying Statins +# 3. Now link to labels via product_to_rxnorm +target_label_ids <- merged_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis) %>% + pull(label_id) -We access the `categories` table inside the `drugbank` list to find all drugs classified as "Statins". +print(paste("Found", length(target_label_ids), "labels")) -```{r find-statins} -# Note the nested path: merged_db$drugbank$drugs$categories -anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% - filter(category == "Anticoagulants") %>% - pull(drugbank_id) +# 4. Extract adverse events for these labels +ae_data <- merged_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids) +print(paste("Total adverse event records:", NROW(ae_data))) + +# 5. Summarize top adverse events by MedDRA ID +ae_summary <- ae_data %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(merged_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) + +# Handle NAs: For missing MedDRA names, we'll add them manually for top events +# In production, you'd use the complete MedDRA dictionary +ae_summary <- ae_summary %>% + mutate(meddra_name = case_when( + effect_meddra_id == 10033336 ~ "Pain", + effect_meddra_id == 10039769 ~ "Rash", + effect_meddra_id == 10052995 ~ "Hot flush", + effect_meddra_id == 10009226 ~ "Constipation", + effect_meddra_id == 10006068 ~ "Bone pain", + TRUE ~ meddra_name + )) %>% + rename(Adverse_Event = meddra_name) + +print(ae_summary) +``` + + +### 3.3 Retrieve Mechanistic Context +To complete the analysis, we pull the biological targets of Leuprolide from the drugbank slot. + +```{r context} +targets <- merged_db$drugbank$cett$targets$general_information %>% + filter(drugbank_id == target_drug_id) %>% + select(name) + +print(paste("Mechanism Target:", targets$name[1])) +``` -anticoagulant_drugs <- merged_db$drugbank$drugs$general_information %>% - filter(drugbank_id %in% anticoagulant_ids) -datatable( - anticoagulant_drugs %>% select(drugbank_id, name), - caption = "Anticoagulants Found in DrugBank" +### 3.4 Visualization +Finally, we use canvasXpress to visualize the side effect profile. This plot represents the seamless integration of data: selecting a drug by its DrugBank ID (Mechanism) and viewing its OnSIDES (Phenotype) data. + +```{r visualization} +cx_data <- data.frame(Count = ae_summary$Count) +rownames(cx_data) <- ae_summary$Adverse_Event + +canvasXpress( + data = t(cx_data), + graphType = "Bar", + title = "Integrated Analysis: Leuprolide (DB00007)", + subtitle = paste("Mechanism:", targets$name[1]), + xAxisTitle = "Frequency in OnSIDES Labels", + yAxisTitle = "Adverse Event", + showLegend = FALSE ) ``` -### 2.2 Finding and Visualizing Common Side Effects -Now, we can filter our `high_confidence` table from the `integrated_data` list to find the side effects associated with these anticoagulants and count their occurrences. +## 4. Second Scientific Case Study: Leuprolide (DB00007) +Let's analyze the second drug in our sample data to demonstrate reproducibility. + +```{r second_case} +# Analyze Calcitriol (Vitamin D analog) +target_drug_id_2 <- "DB00136" + +# Get RxCUI +mapping_df_2 <- merged_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id_2) + +target_rxcui_2 <- mapping_df_2$rxcui[1] + +# Get ingredient name +ingredient_name_2 <- merged_db$vocab_rxnorm_ingredient_enriched %>% + filter(rxnorm_id == target_rxcui_2) %>% + pull(rxnorm_name) + +print(paste("Analyzing:", ingredient_name_2)) + +# Get products +product_rxcuis_2 <- merged_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui_2) %>% + pull(product_id) + +# Get labels +target_label_ids_2 <- merged_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis_2) %>% + pull(label_id) + +# Extract adverse events +ae_data_2 <- merged_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids_2) + +# Summarize +ae_summary_2 <- ae_data_2 %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(merged_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) + +# Fill NAs if needed +ae_summary_2 <- ae_summary_2 %>% + mutate(meddra_name = case_when( + is.na(meddra_name) ~ paste0("MedDRA_", effect_meddra_id), + TRUE ~ meddra_name + )) + +print(ae_summary_2) + +# Get target info +targets_2 <- merged_db$drugbank$cett$targets$general_information %>% + filter(drugbank_id == target_drug_id_2) %>% + select(name) + +print(paste("Primary Target:", targets_2$name[1])) +``` + +## 5. Comparative Analysis + +Now let's compare the adverse event profiles of both drugs side-by-side. + +```{r comparative_analysis} +# Prepare comparison data - handle NAs in names first +ae_summary <- ae_summary %>% + mutate(Adverse_Event = ifelse(is.na(Adverse_Event) | Adverse_Event == "NA", + paste0("Unknown_", effect_meddra_id), + Adverse_Event)) %>% + mutate(Drug = "Leuprolide") %>% + select(Adverse_Event, Count, Drug) -```{r count-effects} -anticoagulant_side_effects <- merged_db$integrated_data$high_confidence_enriched %>% - filter(drugbank_id %in% anticoagulant_ids) %>% - count(effect_meddra_id, sort = TRUE, name = "Frequency") %>% - filter(!is.na(effect_meddra_id)) # Remove any potential NA values +ae_summary_2 <- ae_summary_2 %>% + mutate(meddra_name = ifelse(is.na(meddra_name) | meddra_name == "NA", + paste0("Unknown_", effect_meddra_id), + meddra_name)) %>% + rename(Adverse_Event = meddra_name) %>% + mutate(Drug = "Calcitriol") %>% + select(Adverse_Event, Count, Drug) -# Display the results in an interactive table -datatable( - anticoagulant_side_effects, - options = list(pageLength = 10), - caption = "Table 1: High-Confidence Side Effects Associated with Anticoagulants" +# Combine and select top 5 for each drug +combined_ae <- bind_rows(ae_summary, ae_summary_2) %>% + group_by(Drug) %>% + slice_max(Count, n = 5) %>% + ungroup() + +# Reshape for canvasXpress +comparison_matrix <- combined_ae %>% + pivot_wider(names_from = Drug, values_from = Count, values_fill = 0) + +# Create matrix format +cx_compare <- as.data.frame(comparison_matrix[, -1]) +rownames(cx_compare) <- comparison_matrix$Adverse_Event + +print(cx_compare) + + +# Visualization +canvasXpress( + data = cx_compare, + graphType = "BarLine", + title = "Comparative Adverse Event Profiles", + subtitle = "Leuprolide vs Calcitriol", + xAxisTitle = "Frequency", + yAxisTitle = "Adverse Event", + legendPosition = "topRight" ) ``` -The plot clearly shows "Myalgia" (muscle pain) as the most frequent high-confidence side effect, which is clinically well-established for statins and validates our integrated data. +## 7. Statistical Enrichment Analysis +Let's identify which adverse events are significantly enriched in drugs targeting specific protein families. + +```{r enrichment_analysis} +# Get all drugs with target information +all_targets <- merged_db$drugbank$cett$targets$general_information %>% + select(drugbank_id, name, organism) + +# Simplify target names to protein families +all_targets <- all_targets %>% + mutate(protein_family = case_when( + grepl("receptor", name, ignore.case = TRUE) ~ "Receptor", + grepl("enzyme", name, ignore.case = TRUE) ~ "Enzyme", + grepl("transporter", name, ignore.case = TRUE) ~ "Transporter", + TRUE ~ "Other" + )) + +# For this example, let's focus on the "Receptor" class +receptor_drugs <- all_targets %>% + filter(protein_family == "Receptor") %>% + pull(drugbank_id) %>% + unique() + +print(paste("Found", length(receptor_drugs), "drugs targeting receptors")) -## Conclusion +# Get all adverse events for receptor-targeting drugs +receptor_rxcui <- merged_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id %in% receptor_drugs) %>% + pull(rxcui) + +# Map to products and labels +receptor_products <- merged_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id %in% receptor_rxcui) %>% + pull(product_id) + +receptor_labels <- merged_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% receptor_products) %>% + pull(label_id) + +# Get adverse events +receptor_ae_data <- merged_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% receptor_labels) + +# Calculate enrichment (frequency comparison) +receptor_ae_summary <- receptor_ae_data %>% + group_by(effect_meddra_id) %>% + summarise(Receptor_Count = n()) %>% + arrange(desc(Receptor_Count)) %>% + head(10) %>% + left_join(merged_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + mutate(meddra_name = ifelse(is.na(meddra_name), + paste0("MedDRA_", effect_meddra_id), + meddra_name)) + +print(receptor_ae_summary) + +# Visualize enriched adverse events +cx_enrichment <- data.frame(Count = receptor_ae_summary$Receptor_Count) +rownames(cx_enrichment) <- receptor_ae_summary$meddra_name + +canvasXpress( + data = t(cx_enrichment), + graphType = "Bar", + title = "Enriched Adverse Events: Receptor-Targeting Drugs", + xAxisTitle = "Frequency Across All Receptor Drugs", + yAxisTitle = "Adverse Event", + showLegend = FALSE +) +``` -The `merge_drugbank_onsides` function, respecting the scalable `dvobject` structure, allows for clear and powerful integration of disparate datasets. By maintaining distinct namespaces for each database (`$drugbank`, `$onsides`) and providing a dedicated list for `integrated_data`, the final object is both easy to navigate and ready for complex, multi-database analyses. +## 8. Conclusion +This vignette demonstrated the power of the merge_drugbank_onsides() function for integrating mechanistic and real-world pharmacovigilance data From 0970d71bdfd2bc3f8bfc0b85b8fee7c19244e252 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Mon, 8 Dec 2025 16:33:35 +0200 Subject: [PATCH 23/57] #177, updated add_database_info documentation --- R/dvobject_metadata.R | 1 + man/add_database_info.Rd | 2 ++ 2 files changed, 3 insertions(+) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index 1ac4e81..59cd518 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -15,6 +15,7 @@ init_dvobject <- function() { #' add_database_info #' Assign passed databases db metadata to passed dvobject #' +#' @param dvobject dvobject to assign metadata to it #' @param db_type database type (defualt="DrugBank") #' @param db_version database version as string #' @param db_exported_date database official export date diff --git a/man/add_database_info.Rd b/man/add_database_info.Rd index 9bee2d3..19f97aa 100644 --- a/man/add_database_info.Rd +++ b/man/add_database_info.Rd @@ -13,6 +13,8 @@ add_database_info( ) } \arguments{ +\item{dvobject}{dvobject to assign metadata to it} + \item{db_type}{database type (defualt="DrugBank")} \item{db_version}{database version as string} From ab29013d8bb631fa4e828d71c7705007eae91bf3 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Mon, 8 Dec 2025 17:31:34 +0200 Subject: [PATCH 24/57] #177, fixed CMD notes --- R/merge_helpers.R | 7 ++++--- R/utils.R | 40 ++++++++++++++++++++++------------------ 2 files changed, 26 insertions(+), 21 deletions(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index f9c6d9e..d485c68 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -20,7 +20,8 @@ #' @return A new dvobject containing the integrated data. #' #' @export -#' @importFrom dplyr .data filter select rename mutate left_join +#' @importFrom dplyr filter select rename mutate left_join +#' @importFrom rlang .data #' #' @examples #' \dontrun{ @@ -73,8 +74,8 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { # --- Step 1: Create the Bridge (RxCUI Mapping Table) --- message("Creating DrugBank ID <-> RxCUI mapping table...") rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% - dplyr::filter(resource == "RxCUI") %>% - dplyr::select(all_of("drugbank_id"), rxcui = identifier) + dplyr::filter(.data$resource == "RxCUI") %>% + dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) # --- Step 2: Enrich OnSIDES Tables --- message("Enriching OnSIDES tables with DrugBank IDs...") diff --git a/R/utils.R b/R/utils.R index 870b5eb..ffa0889 100644 --- a/R/utils.R +++ b/R/utils.R @@ -3,6 +3,8 @@ #' @param component_name componemt name #' @param drug_ids passed drugs ids to subset for #' +#' @importFrom rlang .data +#' #' @return A new, smaller dvobject with the same structure. #' @noRd #' @keywords internal @@ -16,7 +18,7 @@ subset_cett_component <- function(component, component_name, drug_ids) { # Step A: Filter the top-level `general_information` table by drug_id. # This is our anchor. general_info_filtered <- component$general_information %>% - dplyr::filter(drugbank_id %in% drug_ids) + dplyr::filter(.data$drugbank_id %in% drug_ids) # Step B: From this anchor, get the set of relevant intermediate IDs. relevant_intermediate_ids <- general_info_filtered[[intermediate_id_col]] %>% @@ -61,7 +63,8 @@ subset_cett_component <- function(component, component_name, drug_ids) { #' @return A new, smaller dvobject with the same structure and attributes. #' #' @export -#' @importFrom dplyr .data filter +#' @importFrom dplyr filter +#' @importFrom rlang .data #' #' @examples #' \dontrun{ @@ -87,7 +90,7 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { # Most tables here link directly via drugbank_id if (is.data.frame(sub_table) && ("drugbank_id" %in% names(sub_table))) { filtered_subtable<- sub_table %>% - dplyr::filter(drugbank_id %in% drug_ids) + dplyr::filter(.data$drugbank_id %in% drug_ids) if (NROW(filtered_subtable) > 0) { new_dvobject$drugs[[name]] <- filtered_subtable } @@ -100,7 +103,7 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { if (NROW(dvobject[[name]]) > 0) { message(paste("Subsetting", name, "...")) filtered_subtable <- dvobject[[name]] %>% - dplyr::filter(drugbank_id %in% drug_ids) + dplyr::filter(.data$drugbank_id %in% drug_ids) if (NROW(filtered_subtable) > 0) { new_dvobject[[name]] <- filtered_subtable } @@ -115,7 +118,7 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { sub_table <- dvobject$references$drugs[[name]] if (is.data.frame(sub_table) && "drugbank_id" %in% names(sub_table)) { filtered_subtable <- sub_table %>% - dplyr::filter(drugbank_id %in% drug_ids) + dplyr::filter(.data$drugbank_id %in% drug_ids) if (NROW(filtered_subtable) > 0) { new_dvobject$references$drugs[[name]] <- filtered_subtable } @@ -186,7 +189,8 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { #' @param ingredient_ids A character vector of RxNorm CUIs (ingredients) to keep. #' #' @export -#' @importFrom dplyr .data filter pull +#' @importFrom dplyr filter pull +#' @importFrom rlang .data #' #' @return A new, smaller dvobject with the same structure. #' @family utils @@ -202,20 +206,20 @@ subset_onsides_dvobject <- function(dvobject, ingredient_ids) { message("Subsetting OnSIDES: Identifying all related keys...") # Find all products containing our target ingredients relevant_product_ids <- dvobject$vocab_rxnorm_ingredient_to_product %>% - dplyr::filter(ingredient_id %in% ingredient_ids) %>% - dplyr::pull(product_id) %>% + dplyr::filter(.data$ingredient_id %in% ingredient_ids) %>% + dplyr::pull(.data$product_id) %>% unique() # Find all labels associated with those products relevant_label_ids <- dvobject$product_to_rxnorm %>% - dplyr::filter(rxnorm_product_id %in% relevant_product_ids) %>% - dplyr::pull(label_id) %>% + dplyr::filter(.data$rxnorm_product_id %in% relevant_product_ids) %>% + dplyr::pull(.data$label_id) %>% unique() # --- 2. Filter the main data tables --- message("Filtering main OnSIDES data tables...") product_adverse_effect <- dvobject$product_adverse_effect %>% - dplyr::filter(product_label_id %in% relevant_label_ids) + dplyr::filter(.data$product_label_id %in% relevant_label_ids) if (NROW(product_adverse_effect) > 0) { new_dvobject$product_adverse_effect <- product_adverse_effect @@ -223,7 +227,7 @@ subset_onsides_dvobject <- function(dvobject, ingredient_ids) { if ("high_confidence" %in% names(dvobject)) { high_confidence <- dvobject$high_confidence %>% - dplyr::filter(ingredient_id %in% ingredient_ids) + dplyr::filter(.data$ingredient_id %in% ingredient_ids) if (NROW(high_confidence) > 0) { new_dvobject$high_confidence <- high_confidence @@ -233,21 +237,21 @@ subset_onsides_dvobject <- function(dvobject, ingredient_ids) { # --- 3. Filter the "bridge" and vocabulary tables to keep the subset lean --- message("Filtering vocabulary and mapping tables...") product_label <- dvobject$product_label %>% - dplyr::filter(label_id %in% relevant_label_ids) + dplyr::filter(.data$label_id %in% relevant_label_ids) if (NROW(product_label) > 0) { new_dvobject$product_label <- product_label } product_to_rxnorm <- dvobject$product_to_rxnorm %>% - dplyr::filter(label_id %in% relevant_label_ids) + dplyr::filter(.data$label_id %in% relevant_label_ids) if (NROW(product_to_rxnorm) > 0) { new_dvobject$product_to_rxnorm <- product_to_rxnorm } vocab_rxnorm_ingredient_to_product <- dvobject$vocab_rxnorm_ingredient_to_product %>% - dplyr::filter(ingredient_id %in% ingredient_ids) + dplyr::filter(.data$ingredient_id %in% ingredient_ids) if (NROW(vocab_rxnorm_ingredient_to_product) > 0) { new_dvobject$vocab_rxnorm_ingredient_to_product <- vocab_rxnorm_ingredient_to_product @@ -257,21 +261,21 @@ subset_onsides_dvobject <- function(dvobject, ingredient_ids) { relevant_meddra_ids <- new_dvobject$product_adverse_effect$effect_meddra_id %>% unique() vocab_meddra_adverse_effect <- dvobject$vocab_meddra_adverse_effect %>% - dplyr::filter(meddra_id %in% relevant_meddra_ids) + dplyr::filter(.data$meddra_id %in% relevant_meddra_ids) if (NROW(vocab_meddra_adverse_effect) > 0) { new_dvobject$vocab_meddra_adverse_effect <- vocab_meddra_adverse_effect } vocab_rxnorm_ingredient <- dvobject$vocab_rxnorm_ingredient %>% - dplyr::filter(rxnorm_id %in% ingredient_ids) + dplyr::filter(.data$rxnorm_id %in% ingredient_ids) if (NROW(vocab_rxnorm_ingredient) > 0) { new_dvobject$vocab_rxnorm_ingredient <- vocab_rxnorm_ingredient } vocab_rxnorm_product <- dvobject$vocab_rxnorm_product %>% - dplyr::filter(rxnorm_id %in% relevant_product_ids) + dplyr::filter(.data$rxnorm_id %in% relevant_product_ids) if (NROW(vocab_rxnorm_product) > 0) { new_dvobject$vocab_rxnorm_product <- vocab_rxnorm_product From 2708444a07f18951d73ff7024af240210f59588c Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 14 Dec 2025 18:31:52 +0200 Subject: [PATCH 25/57] #176, Added two sides parser --- .github/workflows/rhub.yaml | 95 +++++++++++++++++++++++++++++++++++++ NAMESPACE | 2 + R/nsides_parsers.R | 57 ++++++++++++++++++++++ R/onsides_parser.R | 1 + man/parseTWOSIDES.Rd | 45 ++++++++++++++++++ 5 files changed, 200 insertions(+) create mode 100644 .github/workflows/rhub.yaml create mode 100644 R/nsides_parsers.R create mode 100644 man/parseTWOSIDES.Rd diff --git a/.github/workflows/rhub.yaml b/.github/workflows/rhub.yaml new file mode 100644 index 0000000..74ec7b0 --- /dev/null +++ b/.github/workflows/rhub.yaml @@ -0,0 +1,95 @@ +# R-hub's generic GitHub Actions workflow file. It's canonical location is at +# https://github.com/r-hub/actions/blob/v1/workflows/rhub.yaml +# You can update this file to a newer version using the rhub2 package: +# +# rhub::rhub_setup() +# +# It is unlikely that you need to modify this file manually. + +name: R-hub +run-name: "${{ github.event.inputs.id }}: ${{ github.event.inputs.name || format('Manually run by {0}', github.triggering_actor) }}" + +on: + workflow_dispatch: + inputs: + config: + description: 'A comma separated list of R-hub platforms to use.' + type: string + default: 'linux,windows,macos' + name: + description: 'Run name. You can leave this empty now.' + type: string + id: + description: 'Unique ID. You can leave this empty now.' + type: string + +jobs: + + setup: + runs-on: ubuntu-latest + outputs: + containers: ${{ steps.rhub-setup.outputs.containers }} + platforms: ${{ steps.rhub-setup.outputs.platforms }} + + steps: + # NO NEED TO CHECKOUT HERE + - uses: r-hub/actions/setup@v1 + with: + config: ${{ github.event.inputs.config }} + id: rhub-setup + + linux-containers: + needs: setup + if: ${{ needs.setup.outputs.containers != '[]' }} + runs-on: ubuntu-latest + name: ${{ matrix.config.label }} + strategy: + fail-fast: false + matrix: + config: ${{ fromJson(needs.setup.outputs.containers) }} + container: + image: ${{ matrix.config.container }} + + steps: + - uses: r-hub/actions/checkout@v1 + - uses: r-hub/actions/platform-info@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + - uses: r-hub/actions/setup-deps@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + - uses: r-hub/actions/run-check@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + + other-platforms: + needs: setup + if: ${{ needs.setup.outputs.platforms != '[]' }} + runs-on: ${{ matrix.config.os }} + name: ${{ matrix.config.label }} + strategy: + fail-fast: false + matrix: + config: ${{ fromJson(needs.setup.outputs.platforms) }} + + steps: + - uses: r-hub/actions/checkout@v1 + - uses: r-hub/actions/setup-r@v1 + with: + job-config: ${{ matrix.config.job-config }} + token: ${{ secrets.RHUB_TOKEN }} + - uses: r-hub/actions/platform-info@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + - uses: r-hub/actions/setup-deps@v1 + with: + job-config: ${{ matrix.config.job-config }} + token: ${{ secrets.RHUB_TOKEN }} + - uses: r-hub/actions/run-check@v1 + with: + job-config: ${{ matrix.config.job-config }} + token: ${{ secrets.RHUB_TOKEN }} diff --git a/NAMESPACE b/NAMESPACE index a85bf8e..8991267 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -6,6 +6,7 @@ export(drug_node_options) export(merge_drugbank_onsides) export(parseDrugBank) export(parseOnSIDES) +export(parseTWOSIDES) export(references_node_options) export(show_dvobject_metadata) export(subset_drugbank_dvobject) @@ -36,6 +37,7 @@ importFrom(purrr,is_empty) importFrom(purrr,is_null) importFrom(purrr,map_chr) importFrom(purrr,map_df) +importFrom(rlang,.data) importFrom(tibble,as_tibble) importFrom(tibble,as_tibble_row) importFrom(tibble,tibble) diff --git a/R/nsides_parsers.R b/R/nsides_parsers.R new file mode 100644 index 0000000..118b66f --- /dev/null +++ b/R/nsides_parsers.R @@ -0,0 +1,57 @@ +#' Parse the TWOSIDES Drug-Drug Interaction Database +#' +#' Reads the \href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} data file, which contains adverse event data for pairs of +#' drugs taken concurrently (N=2 interactions). +#' +#' \href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} is a database of drug-drug interaction safety signals +#' mined from the FDA's Adverse Event Reporting System using the same +#' approach as is used to generate OffSIDES. +#' +#' Database fields as follow: +#' \describe{ +#' \item{drug_1_rxnorn_id}{RxNORM identifier for drug 1} +#' \item{drug_1_concept_name}{RxNORM name string for drug 1} +#' \item{drug_2_rxnorm_id}{RxNORM identifier for drug 2} +#' \item{drug_2_concept_name}{RxNORM name string for drug 3} +#' \item{condition_meddra_id}{MedDRA identifier for the side effect} +#' \item{condition_concpet_name}{MedDRA name string for the side effect} +#' \item{A}{The number of reports for the pair of drugs that report the side effect} +#' \item{B}{The number of reports for the pair of drugs that do not report the side effect} +#' \item{C}{The number of reports for other PSM matched drugs (including perhaps the single versions of drug 1 or drug 2) that report the side effect} +#' \item{D}{The number of reports for other PSM matched drugs and other side effects} +#' \item{PRR}{Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D))} +#' \item{PRR_error}{Error estimate of the PRR} +#' \item{mean_reporting_frequency}{Proportion of reports for the drug that report the side effect, A/(A+B)} +#' } +#' +#' @param twosides_file_path Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). +#' @param db_version used twoside version (default = NULL) +#' @param db_exported_date used twoside release date (default = NULL) +#' +#' @return A dvobject of class `TWOSIDESDB` containing the `drug_drug_interactions` +#' data frame and associated metadata. +#' +#' @export +#' @importFrom data.table fread +parseTWOSIDES <- function(twosides_file_path, + db_version = NULL, + db_exported_date = NULL) { + if (!file.exists(twosides_file_path)) { + stop("TWOSIDES file not found at path: ", twosides_file_path) + } + + message("Parsing TWOSIDES drug-drug interaction data...") + twosides_data <- data.table::fread(twosides_file_path) + message("Parsing complete.") + + twosides_db <- init_dvobject() + twosides_db$drug_drug_interactions <- twosides_data + + twosides_db <- add_database_info( + dvobject = twosides_db, + db_type = "TWOSIDESDB", + db_version = db_version, + db_exported_date = db_exported_date) + + twosides_db +} diff --git a/R/onsides_parser.R b/R/onsides_parser.R index d92bf7d..b81a4a9 100644 --- a/R/onsides_parser.R +++ b/R/onsides_parser.R @@ -64,4 +64,5 @@ parseOnSIDES <- function(dataDir, db_type = "OnSIDES", db_version = db_version, db_exported_date = db_exported_date) + db_tables } diff --git a/man/parseTWOSIDES.Rd b/man/parseTWOSIDES.Rd new file mode 100644 index 0000000..637cfbd --- /dev/null +++ b/man/parseTWOSIDES.Rd @@ -0,0 +1,45 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/nsides_parsers.R +\name{parseTWOSIDES} +\alias{parseTWOSIDES} +\title{Parse the TWOSIDES Drug-Drug Interaction Database} +\usage{ +parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL) +} +\arguments{ +\item{twosides_file_path}{Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz').} + +\item{db_version}{used twoside version (default = NULL)} + +\item{db_exported_date}{used twoside release date (default = NULL)} +} +\value{ +A dvobject of class `TWOSIDESDB` containing the `drug_drug_interactions` + data frame and associated metadata. +} +\description{ +Reads the \href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} data file, which contains adverse event data for pairs of +drugs taken concurrently (N=2 interactions). +} +\details{ +\href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} is a database of drug-drug interaction safety signals +mined from the FDA's Adverse Event Reporting System using the same +approach as is used to generate OffSIDES. + +Database fields as follow: +\describe{ +\item{drug_1_rxnorn_id}{RxNORM identifier for drug 1} +\item{drug_1_concept_name}{RxNORM name string for drug 1} +\item{drug_2_rxnorm_id}{RxNORM identifier for drug 2} +\item{drug_2_concept_name}{RxNORM name string for drug 3} +\item{condition_meddra_id}{MedDRA identifier for the side effect} +\item{condition_concpet_name}{MedDRA name string for the side effect} +\item{A}{The number of reports for the pair of drugs that report the side effect} +\item{B}{The number of reports for the pair of drugs that do not report the side effect} +\item{C}{The number of reports for other PSM matched drugs (including perhaps the single versions of drug 1 or drug 2) that report the side effect} +\item{D}{The number of reports for other PSM matched drugs and other side effects} +\item{PRR}{Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D))} +\item{PRR_error}{Error estimate of the PRR} +\item{mean_reporting_frequency}{Proportion of reports for the drug that report the side effect, A/(A+B)} +} +} From c3f953a088d743bf993a663e5b25d810d4b13ec7 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 14 Dec 2025 19:30:02 +0200 Subject: [PATCH 26/57] #176, updated package version --- DESCRIPTION | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/DESCRIPTION b/DESCRIPTION index ad67057..5f8f3da 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,6 +1,6 @@ Package: dbparser Title: Drugs Databases Parser -Version: 2.1.0.9001 +Version: 2.1.0.9002 Authors@R: c( person("Mohammed", "Ali", email = "moh_fcis@yahoo.com", role = c("aut", "cre")), From 68d69044d8e9eac53df1eba17c4e8814c3779812 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sun, 14 Dec 2025 19:30:27 +0200 Subject: [PATCH 27/57] #176, removed unneeded imports --- NAMESPACE | 1 - R/merge_helpers.R | 3 +-- R/utils.R | 8 +++----- 3 files changed, 4 insertions(+), 8 deletions(-) diff --git a/NAMESPACE b/NAMESPACE index 8991267..aefe01e 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -37,7 +37,6 @@ importFrom(purrr,is_empty) importFrom(purrr,is_null) importFrom(purrr,map_chr) importFrom(purrr,map_df) -importFrom(rlang,.data) importFrom(tibble,as_tibble) importFrom(tibble,as_tibble_row) importFrom(tibble,tibble) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index d485c68..b721107 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -20,8 +20,7 @@ #' @return A new dvobject containing the integrated data. #' #' @export -#' @importFrom dplyr filter select rename mutate left_join -#' @importFrom rlang .data +#' @importFrom dplyr filter select rename mutate left_join .data #' #' @examples #' \dontrun{ diff --git a/R/utils.R b/R/utils.R index ffa0889..9492b27 100644 --- a/R/utils.R +++ b/R/utils.R @@ -3,7 +3,7 @@ #' @param component_name componemt name #' @param drug_ids passed drugs ids to subset for #' -#' @importFrom rlang .data +#' @importFrom dplyr .data #' #' @return A new, smaller dvobject with the same structure. #' @noRd @@ -63,8 +63,7 @@ subset_cett_component <- function(component, component_name, drug_ids) { #' @return A new, smaller dvobject with the same structure and attributes. #' #' @export -#' @importFrom dplyr filter -#' @importFrom rlang .data +#' @importFrom dplyr filter .data #' #' @examples #' \dontrun{ @@ -189,8 +188,7 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { #' @param ingredient_ids A character vector of RxNorm CUIs (ingredients) to keep. #' #' @export -#' @importFrom dplyr filter pull -#' @importFrom rlang .data +#' @importFrom dplyr filter pull .data #' #' @return A new, smaller dvobject with the same structure. #' @family utils From 971644c5331c9db04ea233a4ae78391ac45c3a6f Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Thu, 25 Dec 2025 16:36:54 +0200 Subject: [PATCH 28/57] #176, implemented merge_drugbank_onsides method --- NAMESPACE | 2 + R/merge_helpers.R | 121 +++++++++++++++++++++++++++ man/merge_drugbank_twosides.Rd | 25 ++++++ tests/testthat/test_twoside_parser.R | 16 ++++ 4 files changed, 164 insertions(+) create mode 100644 man/merge_drugbank_twosides.Rd create mode 100644 tests/testthat/test_twoside_parser.R diff --git a/NAMESPACE b/NAMESPACE index aefe01e..3334710 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -4,6 +4,7 @@ export(add_database_info) export(cett_nodes_options) export(drug_node_options) export(merge_drugbank_onsides) +export(merge_drugbank_twosides) export(parseDrugBank) export(parseOnSIDES) export(parseTWOSIDES) @@ -24,6 +25,7 @@ importFrom(XML,xmlToList) importFrom(XML,xmlValue) importFrom(data.table,fread) importFrom(dplyr,.data) +importFrom(dplyr,distinct) importFrom(dplyr,filter) importFrom(dplyr,left_join) importFrom(dplyr,mutate) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index b721107..cb150bb 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -123,3 +123,124 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { message("Merge complete.") merged_object } + + +#' Merge a DrugBank dvobject with a TWOSIDES dvobject +#' +#' Integrates drug-drug interaction data from TWOSIDES with the rich mechanistic +#' information from DrugBank. This function is chainable and can accept a raw +#' DrugBank object or an already-merged dvobject. +#' +#' @param db_object A dvobject from `parseDrugBank()` or an existing merged dvobject. +#' @param twosides_db A dvobject from `parseTWOSIDES()`. +#' +#' @return A new, nested dvobject with the TWOSIDES data added. +#' +#' @importFrom dplyr filter select rename mutate left_join .data distinct +#' @export +#' Merge a DrugBank dvobject with a TWOSIDES dvobject +#' +#' Integrates drug-drug interaction data from TWOSIDES with DrugBank. +#' Supports piping and chaining. +#' +#' @param db_object A dvobject from `parseDrugBank()` OR an existing merged +#' dvobject (containing `$drugbank`). +#' @param twosides_db A dvobject from `parseTWOSIDES()`. +#' +#' @export +merge_drugbank_twosides <- function(db_object, twosides_db) { + + # --- Step 0: Input Validation and Hub Detection (Pipe Friendly) --- + if ("drugbank" %in% names(db_object)) { + # Case A: Input is an already-merged object + drugbank_db <- db_object$drugbank + merged_object <- db_object + } else { + # Case B: Input is a raw DrugBank object + drugbank_db <- db_object + merged_object <- init_dvobject() + merged_object$drugbank <- db_object + attr(merged_object, "DrugBankDB") <- attr(drugbank_db, "original_db_info") + } + + # Validate inputs + if (!inherits(drugbank_db, "dvobject") || (!"drugs" %in% names(drugbank_db))) { + stop("`db_object` must contain a valid DrugBank dvobject.") + } + if (!inherits(drugbank_db, "dvobject") || (!"external_identifiers" %in% names(drugbank_db$drugs))) { + stop("`drugbank_db` must contain external_identifiers data.") + } + if (!is.list(twosides_db) || !("drug_drug_interactions" %in% names(twosides_db))) { + stop("`twosides_db` must be a valid dvobject from parseTWOSIDES().") + } + + # --- Step 1: Create Bridge --- + message("Creating DrugBank ID <-> RxCUI mapping table...") + rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% + dplyr::filter(.data$resource == "RxCUI") %>% + dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) %>% + dplyr::distinct() + + # Drug name lookup + drug_name_lookup <- drugbank_db$drugs$general_information %>% + dplyr::select(all_of("drugbank_id"), drug_name = .data$name) + + # --- Step 2: Enrich TWOSIDES Data --- + message("Enriching TWOSIDES data with DrugBank information...") + + # Prepare lookup tables for double joining + rxcui_map_1 <- rxcui_mapping_df %>% dplyr::rename(drugbank_id_1 = .data$drugbank_id) + rxcui_map_2 <- rxcui_mapping_df %>% dplyr::rename(drugbank_id_2 = .data$drugbank_id) + + drug_name_lookup_1 <- drug_name_lookup %>% + dplyr::rename(drug_name_1 = .data$drug_name, drugbank_id_1 = .data$drugbank_id) + drug_name_lookup_2 <- drug_name_lookup %>% + dplyr::rename(drug_name_2 = .data$drug_name, drugbank_id_2 = .data$drugbank_id) + + enriched_ddis <- twosides_db$drug_drug_interactions %>% + # LOGIC CHANGE 1: Union (OR) Filter + # Note the spelling: rxnorn + dplyr::filter((.data$drug_1_rxnorn_id %in% rxcui_mapping_df$rxcui) | + (.data$drug_2_rxnorm_id %in% rxcui_mapping_df$rxcui)) %>% + + # Join for Drug 1 (using 'rxnorn' spelling) + dplyr::left_join(rxcui_map_1, by = c("drug_1_rxnorn_id" = "rxcui")) %>% + dplyr::left_join(drug_name_lookup_1, by = "drugbank_id_1") %>% + + # Join for Drug 2 (Twosides seems to use 'rxnorm' for the second one? Or check if consistent) + # Based on your screenshot, assuming consistent spelling might be safer, + # but check your colnames. Usually data is consistent. + # If the second col is "drug_2_rxnorm_id" (with m), keep as is. + dplyr::left_join(rxcui_map_2, by = c("drug_2_rxnorm_id" = "rxcui")) %>% + dplyr::left_join(drug_name_lookup_2, by = "drugbank_id_2") %>% + + # LOGIC CHANGE 2: Keep if at least one side matched + dplyr::filter(!is.na(.data$drugbank_id_1) | !is.na(.data$drugbank_id_2)) %>% + + # LOGIC CHANGE 3: Fallback names to prevent NAs + dplyr::mutate( + drug_name_1 = dplyr::coalesce(.data$drug_name_1, .data$drug_1_concept_name), + drug_name_2 = dplyr::coalesce(.data$drug_name_2, .data$drug_2_concept_name) + ) + + # --- Step 3: Assemble Final Object --- + # Initialize integrated_data if it doesn't exist + if (is.null(merged_object$integrated_data)) { + merged_object$integrated_data <- list() + } + + # Add the new enriched table + merged_object$integrated_data$drug_drug_interactions <- enriched_ddis + + # Add raw Twosides data + merged_object$twosides <- twosides_db + + # --- Step 4: Metadata --- + attr(merged_object, "TwoSidesDB") <- attr(twosides_db, "original_db_info") + + # Prepend new class + class(merged_object) <- unique(c("DrugBankTWOSIDESDb", class(merged_object))) + + message("Merge complete.") + merged_object +} diff --git a/man/merge_drugbank_twosides.Rd b/man/merge_drugbank_twosides.Rd new file mode 100644 index 0000000..8c83041 --- /dev/null +++ b/man/merge_drugbank_twosides.Rd @@ -0,0 +1,25 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/merge_helpers.R +\name{merge_drugbank_twosides} +\alias{merge_drugbank_twosides} +\title{Merge a DrugBank dvobject with a TWOSIDES dvobject} +\usage{ +merge_drugbank_twosides(db_object, twosides_db, meddra_vocab = NULL) +} +\arguments{ +\item{db_object}{A dvobject from `parseDrugBank()` or an existing merged dvobject.} + +\item{twosides_db}{A dvobject from `parseTWOSIDES()`.} + +\item{meddra_vocab}{Optional. A data frame from OnSIDES (`vocab_meddra_adverse_effect`) +to add human-readable names for side effects. Should have columns `meddra_id` +and `meddra_name`.} +} +\value{ +A new, nested dvobject with the TWOSIDES data added. +} +\description{ +Integrates drug-drug interaction data from TWOSIDES with the rich mechanistic +information from DrugBank. This function is chainable and can accept a raw +DrugBank object or an already-merged dvobject. +} diff --git a/tests/testthat/test_twoside_parser.R b/tests/testthat/test_twoside_parser.R new file mode 100644 index 0000000..d9e214b --- /dev/null +++ b/tests/testthat/test_twoside_parser.R @@ -0,0 +1,16 @@ +context("test parse onside nodes") + +test_that( + desc = "parse two side DB - default params", + code = { + local_edition(3) + expect_snapshot( + expect_error(parseTWOSIDES(twosides_file_path = "data_path"))) + data_path <- dirname(unzip(system.file("onside.zip", + package = "dbparser"))[1]) + onside <- parseOnSIDES(dataDir = data_path) + unlink(data_path, recursive = TRUE) + expect_equal(length(onside), 8) + expect_snapshot(show_dvobject_metadata(onside)) + } +) From 3f126ac02fe3e307e53be0a0974b848f5e6fd9c8 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Thu, 25 Dec 2025 18:13:19 +0200 Subject: [PATCH 29/57] #176, Fixed Metadata info for second database --- R/dvobject_metadata.R | 15 +++++++-------- 1 file changed, 7 insertions(+), 8 deletions(-) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index 59cd518..c157525 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -162,14 +162,13 @@ find_second_database <- function(attrs) { potential_second_db <- setdiff(names(attrs), standard_attrs) if (length(potential_second_db) > 0) { - for (db_name in potential_second_db) { - db_attr <- attrs[[db_name]] - required_fields <- c("db_type", "db_version", "db_exported_date") - - if ((is.list(db_attr)) && (all(required_fields %in% names(db_attr)))) { - result$has_second_db <- TRUE - result$second_db_name <- db_name - } + db_name <- potential_second_db[length(potential_second_db)] + db_attr <- attrs[[db_name]] + required_fields <- c("db_type") + + if ((is.list(db_attr)) && (any(required_fields %in% names(db_attr)))) { + result$has_second_db <- TRUE + result$second_db_name <- db_name } } From 22494be4848ea3cc4dde31227d862caca8c62734 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Thu, 25 Dec 2025 18:26:06 +0200 Subject: [PATCH 30/57] #176, updated onside merger to support pip operation --- R/merge_helpers.R | 57 +++++++++++++++++++-------- tests/testthat/test_merge_functions.R | 2 +- 2 files changed, 41 insertions(+), 18 deletions(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index cb150bb..33420f5 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -13,8 +13,10 @@ #' #' The resulting object allows for powerful queries that span both mechanistic data from #' DrugBank and clinical side-effect data from OnSIDES. +#' Supports piping and chaining with other merge functions. #' -#' @param drugbank_db A dvobject produced by `dbparser::parseDrugBank()`. +#' @param db_object A dvobject from `parseDrugBank()` OR an existing merged +#' dvobject (containing `$drugbank`). #' @param onsides_db A dvobject produced by `dbparser::parseOnSIDES()`. #' #' @return A new dvobject containing the integrated data. @@ -53,18 +55,35 @@ #' #' head(targets_of_interest) #' } -merge_drugbank_onsides <- function(drugbank_db, onsides_db) { - # --- Step 0: Input Validation --- +merge_drugbank_onsides <- function(db_object, onsides_db) { + + # --- Step 0: Input Validation and Hub Detection --- + # This logic enables the Pipe (%>%) and Chaining. + + if ("drugbank" %in% names(db_object)) { + # CASE A: Input is an already-merged object (e.g., passed via pipe from another merge) + drugbank_db <- db_object$drugbank + merged_object <- db_object # Start with existing data to preserve previous merges + } else { + # CASE B: Input is a raw DrugBank object + drugbank_db <- db_object + merged_object <- init_dvobject() + merged_object$drugbank <- db_object + attr(merged_object, "DrugBankDB") <- attr(drugbank_db, "original_db_info") + } + + # Validate the Hub if (!inherits(drugbank_db, "dvobject") || (!"drugs" %in% names(drugbank_db))) { - stop("`drugbank_db` must be a valid dvobject from parseDrugBank().") + stop("`db_object` must contain a valid DrugBank dvobject.") } if (!inherits(drugbank_db, "dvobject") || (!"external_identifiers" %in% names(drugbank_db$drugs))) { - stop("`drugbank_db` dvobject must contain external_identifiers data.") + stop("`drugbank_db` must contain external_identifiers data.") } + # Validate the Spoke if (!inherits(onsides_db, "dvobject") || (!"vocab_rxnorm_ingredient" %in% names(onsides_db))) { stop("`onsides_db` must be a valid dvobject from parseOnSIDES().") @@ -74,7 +93,8 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { message("Creating DrugBank ID <-> RxCUI mapping table...") rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% dplyr::filter(.data$resource == "RxCUI") %>% - dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) + dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) %>% + dplyr::distinct() # --- Step 2: Enrich OnSIDES Tables --- message("Enriching OnSIDES tables with DrugBank IDs...") @@ -93,20 +113,23 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { # --- Step 3: Assemble the Final Merged Object --- message("Assembling final merged object...") - # Start with all of DrugBank's data - merged_object <- init_dvobject() - merged_object$drugbank <- drugbank_db - attr(merged_object, "DrugBankDB") <- attr(drugbank_db, "original_db_info") - merged_object$onsides <- list() - merged_object$integrated_data <- list() + # Add OnSIDES structure (Initialize if needed, but append to existing) + if (is.null(merged_object$onsides)) { + merged_object$onsides <- list() + } - # Add all of OnSIDES's data + # Copy all OnSIDES tables for (name in names(onsides_db)) { merged_object$onsides[[name]] <- onsides_db[[name]] } - # Overwrite the original OnSIDES tables with our new enriched versions - merged_object$vocab_rxnorm_ingredient_enriched <- onsides_ingredient_enriched + # Ensure integrated_data list exists + if (is.null(merged_object$integrated_data)) { + merged_object$integrated_data <- list() + } + + merged_object$integrated_data[["vocab_rxnorm_ingredient_enriched"]] <- onsides_ingredient_enriched + if (exists("onsides_hc_enriched")) { merged_object$integrated_data[["high_confidence_enriched"]] <- onsides_hc_enriched } @@ -117,8 +140,8 @@ merge_drugbank_onsides <- function(drugbank_db, onsides_db) { # Update metadata attr(merged_object, "onSideDB") <- attr(onsides_db, "original_db_info") - # Assign a new class - class(merged_object) <- c("DrugBankOnSIDESDb", class(merged_object)) + # Assign a new class (Prepend to keep existing classes like DrugBankTWOSIDESDb) + class(merged_object) <- unique(c("DrugBankOnSIDESDb", class(merged_object))) message("Merge complete.") merged_object diff --git a/tests/testthat/test_merge_functions.R b/tests/testthat/test_merge_functions.R index e95550d..668a29a 100644 --- a/tests/testthat/test_merge_functions.R +++ b/tests/testthat/test_merge_functions.R @@ -26,7 +26,7 @@ test_that( "`onsides_db` must be a valid dvobject from parseOnSIDES().") all_dbs <- merge_drugbank_onsides( - drugbank_db = drugbank, + db_object = drugbank, onsides_db = onside) expect_snapshot(show_dvobject_metadata(all_dbs)) From e56cd80ca02e484bd4fd15d7b09979048891a47f Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Thu, 25 Dec 2025 18:39:12 +0200 Subject: [PATCH 31/57] #176, fixed documentation --- R/merge_helpers.R | 10 ---------- man/merge_drugbank_onsides.Rd | 6 ++++-- man/merge_drugbank_twosides.Rd | 6 +----- 3 files changed, 5 insertions(+), 17 deletions(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 33420f5..23b3126 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -161,16 +161,6 @@ merge_drugbank_onsides <- function(db_object, onsides_db) { #' #' @importFrom dplyr filter select rename mutate left_join .data distinct #' @export -#' Merge a DrugBank dvobject with a TWOSIDES dvobject -#' -#' Integrates drug-drug interaction data from TWOSIDES with DrugBank. -#' Supports piping and chaining. -#' -#' @param db_object A dvobject from `parseDrugBank()` OR an existing merged -#' dvobject (containing `$drugbank`). -#' @param twosides_db A dvobject from `parseTWOSIDES()`. -#' -#' @export merge_drugbank_twosides <- function(db_object, twosides_db) { # --- Step 0: Input Validation and Hub Detection (Pipe Friendly) --- diff --git a/man/merge_drugbank_onsides.Rd b/man/merge_drugbank_onsides.Rd index f67afc4..705e188 100644 --- a/man/merge_drugbank_onsides.Rd +++ b/man/merge_drugbank_onsides.Rd @@ -4,10 +4,11 @@ \alias{merge_drugbank_onsides} \title{Merge DrugBank and OnSIDES Database Objects} \usage{ -merge_drugbank_onsides(drugbank_db, onsides_db) +merge_drugbank_onsides(db_object, onsides_db) } \arguments{ -\item{drugbank_db}{A dvobject produced by `dbparser::parseDrugBank()`.} +\item{db_object}{A dvobject from `parseDrugBank()` OR an existing merged +dvobject (containing `$drugbank`).} \item{onsides_db}{A dvobject produced by `dbparser::parseOnSIDES()`.} } @@ -28,6 +29,7 @@ This function performs the following key steps: The resulting object allows for powerful queries that span both mechanistic data from DrugBank and clinical side-effect data from OnSIDES. +Supports piping and chaining with other merge functions. } \examples{ \dontrun{ diff --git a/man/merge_drugbank_twosides.Rd b/man/merge_drugbank_twosides.Rd index 8c83041..25e9b87 100644 --- a/man/merge_drugbank_twosides.Rd +++ b/man/merge_drugbank_twosides.Rd @@ -4,16 +4,12 @@ \alias{merge_drugbank_twosides} \title{Merge a DrugBank dvobject with a TWOSIDES dvobject} \usage{ -merge_drugbank_twosides(db_object, twosides_db, meddra_vocab = NULL) +merge_drugbank_twosides(db_object, twosides_db) } \arguments{ \item{db_object}{A dvobject from `parseDrugBank()` or an existing merged dvobject.} \item{twosides_db}{A dvobject from `parseTWOSIDES()`.} - -\item{meddra_vocab}{Optional. A data frame from OnSIDES (`vocab_meddra_adverse_effect`) -to add human-readable names for side effects. Should have columns `meddra_id` -and `meddra_name`.} } \value{ A new, nested dvobject with the TWOSIDES data added. 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z$}+1k5j6)k!Dx79x1xT51;>eY2HO;PWoCxvm(#mbf$+`f5XLF%{US-TZ0Yq@^Vc06 z*}`QVbYSd$AViIzLC{UUQKCk!;>LBD$xH%V1rDbM1cP~JMz2M@9BuqV5+{`bTl)Rs z3Mp1_cf4DwT3X(K5!FD=Y5S_h0t4-!3GSe-K>`&ZeR_S{;tz2Bf3bYdU%ZE9{Kb28 z0f&qK`S-71{w)m)Q(aj6ZJHf>@sqclze(W@4tx|UrFq5+sm!d-dV|6CaI8cD9jpuC zDr^ATq%Rk09OzANc*H^lH-Mbyc6!@1!1MMKC%cMMg(kIw(V{3!=>IQJO9u$9&}(Zz z#{d8vjRF8rO928D0~7!V00;oEm6= Date: Thu, 25 Dec 2025 19:23:37 +0200 Subject: [PATCH 33/57] - Added twosides unit tests, #176 --- tests/testthat/_snaps/merge_functions.md | 2 +- tests/testthat/_snaps/twoside_parser.md | 22 ++++++++++++++++++++++ tests/testthat/test_merge_functions.R | 10 +++++----- tests/testthat/test_twoside_parser.R | 11 ++++++----- 4 files changed, 34 insertions(+), 11 deletions(-) create mode 100644 tests/testthat/_snaps/twoside_parser.md diff --git a/tests/testthat/_snaps/merge_functions.md b/tests/testthat/_snaps/merge_functions.md index 1d4850f..2f949b3 100644 --- a/tests/testthat/_snaps/merge_functions.md +++ b/tests/testthat/_snaps/merge_functions.md @@ -77,7 +77,7 @@ onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb onsides$vocab_rxnorm_product 17 3 4.9 Kb + integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb integrated_data$high_confidence_enriched 2 3 1.6 Kb integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb - vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb diff --git a/tests/testthat/_snaps/twoside_parser.md b/tests/testthat/_snaps/twoside_parser.md new file mode 100644 index 0000000..22f7bb9 --- /dev/null +++ b/tests/testthat/_snaps/twoside_parser.md @@ -0,0 +1,22 @@ +# parse two side DB - default params + + Code + expect_error(parseTWOSIDES(twosides_file_path = "data_path")) + +--- + + Code + show_dvobject_metadata(twoside) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 1 0 217.6 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original TWOSIDESDB Unknown Unknown + + === DATA.FRAMES === + Path Rows Cols Size + drug_drug_interactions 1706 13 216.6 Kb + diff --git a/tests/testthat/test_merge_functions.R b/tests/testthat/test_merge_functions.R index 668a29a..69be241 100644 --- a/tests/testthat/test_merge_functions.R +++ b/tests/testthat/test_merge_functions.R @@ -9,19 +9,19 @@ test_that( onside <- readRDS(system.file("onside.RDS", package = "dbparser")) expect_error(merge_drugbank_onsides( - drugbank_db = list(), + db_object = list(), onsides_db = onside), - "`drugbank_db` must be a valid dvobject from parseDrugBank().") + "`db_object` must contain a valid DrugBank dvobject.") invalid_drugbank <- drugbank invalid_drugbank$drugs$external_identifiers <- NULL expect_error(merge_drugbank_onsides( - drugbank_db = invalid_drugbank, + db_object = invalid_drugbank, onsides_db = onside), - "`drugbank_db` dvobject must contain external_identifiers data.") + "`drugbank_db` must contain external_identifiers data.") expect_error(merge_drugbank_onsides( - drugbank_db = drugbank, + db_object = drugbank, onsides_db = list()), "`onsides_db` must be a valid dvobject from parseOnSIDES().") diff --git a/tests/testthat/test_twoside_parser.R b/tests/testthat/test_twoside_parser.R index d9e214b..a56871e 100644 --- a/tests/testthat/test_twoside_parser.R +++ b/tests/testthat/test_twoside_parser.R @@ -6,11 +6,12 @@ test_that( local_edition(3) expect_snapshot( expect_error(parseTWOSIDES(twosides_file_path = "data_path"))) - data_path <- dirname(unzip(system.file("onside.zip", - package = "dbparser"))[1]) - onside <- parseOnSIDES(dataDir = data_path) + data_path <- unzip(system.file("twoside_raw.zip", + package = "dbparser")) + twoside <- parseTWOSIDES(twosides_file_path = data_path) unlink(data_path, recursive = TRUE) - expect_equal(length(onside), 8) - expect_snapshot(show_dvobject_metadata(onside)) + expect_equal(length(twoside), 1) + expect_equal(dim(twoside$drug_drug_interactions), c(1706, 13)) + expect_snapshot(show_dvobject_metadata(twoside)) } ) From 1f305ab577e519067bbe76eb3c9a9bb7b8a20fc6 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Fri, 26 Dec 2025 09:49:14 +0200 Subject: [PATCH 34/57] #176, added twosides unit tests --- R/merge_helpers.R | 1 + tests/testthat/_snaps/merge_functions.md | 74 ++++++++++++++++++++++ tests/testthat/test_merge_functions.R | 80 ++++++++++++++++++++++-- 3 files changed, 149 insertions(+), 6 deletions(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 23b3126..aaec63f 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -192,6 +192,7 @@ merge_drugbank_twosides <- function(db_object, twosides_db) { rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% dplyr::filter(.data$resource == "RxCUI") %>% dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) %>% + dplyr::mutate(rxcui = as.integer(rxcui)) %>% dplyr::distinct() # Drug name lookup diff --git a/tests/testthat/_snaps/merge_functions.md b/tests/testthat/_snaps/merge_functions.md index 2f949b3..c10b006 100644 --- a/tests/testthat/_snaps/merge_functions.md +++ b/tests/testthat/_snaps/merge_functions.md @@ -81,3 +81,77 @@ integrated_data$high_confidence_enriched 2 3 1.6 Kb integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb +# merge drugbank and twoside + + Code + show_dvobject_metadata(all_dbs) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 DrugBankTWOSIDESDb, dvobject 57 3 2 Mb + + === DATABASE METADATA === + Database Type Version Export_Date + First Database DrugBank 5.1 2025-01-02 + Second Database TWOSIDESDB Unknown Unknown + + === DATA.FRAMES === + Path Rows Cols Size + drugbank$drugs$general_information 2 15 8 Kb + drugbank$drugs$drug_classification 2 9 3.8 Kb + drugbank$drugs$synonyms 15 4 3.6 Kb + drugbank$drugs$pharmacology 2 12 18.1 Kb + drugbank$drugs$international_brands 9 3 2.7 Kb + drugbank$drugs$mixtures 5 3 2 Kb + drugbank$drugs$packagers 35 3 6.2 Kb + drugbank$drugs$manufacturers 13 4 2.9 Kb + drugbank$drugs$prices 16 5 4.6 Kb + drugbank$drugs$categories 58 3 9.2 Kb + drugbank$drugs$dosages 189 4 17.4 Kb + drugbank$drugs$atc_codes 4 10 4.3 Kb + drugbank$drugs$patents 35 6 8.6 Kb + drugbank$drugs$drug_interactions 1645 4 514.7 Kb + drugbank$drugs$sequences 1 3 1.3 Kb + drugbank$drugs$calculated_properties 26 4 5.6 Kb + drugbank$drugs$experimental_properties 5 4 2.4 Kb + drugbank$drugs$external_identifiers 30 3 4.7 Kb + drugbank$drugs$pdb_entries 19 2 2.4 Kb + drugbank$drugs$affected_organisms 2 2 1.2 Kb + drugbank$drugs$groups 4 2 1.3 Kb + drugbank$drugs$external_links 5 3 2.1 Kb + drugbank$salts 2 8 2.8 Kb + drugbank$products 190 19 68.6 Kb + drugbank$references$drugs$articles 13 4 6.3 Kb + drugbank$references$drugs$links 11 4 6.1 Kb + drugbank$references$carriers$books 1 4 1.6 Kb + drugbank$references$carriers$articles 15 4 5.4 Kb + drugbank$references$enzymes$books 33 4 8.2 Kb + drugbank$references$enzymes$articles 1573 4 485.5 Kb + drugbank$references$enzymes$links 615 4 164.4 Kb + drugbank$references$enzymes$attachments 55 4 20 Kb + drugbank$references$targets$articles 101 4 27.4 Kb + drugbank$references$targets$links 14 4 7.1 Kb + drugbank$cett$carriers$general_information 1 6 1.9 Kb + drugbank$cett$carriers$actions 2 2 1.2 Kb + drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb + drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb + drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb + drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb + drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb + drugbank$cett$enzymes$general_information 2 8 2.6 Kb + drugbank$cett$enzymes$actions 7 2 1.5 Kb + drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb + drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb + drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb + drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb + drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb + drugbank$cett$targets$general_information 4 6 2.6 Kb + drugbank$cett$targets$actions 10 2 1.9 Kb + drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb + drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb + drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb + drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb + drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb + integrated_data$drug_drug_interactions 1706 17 300.9 Kb + twosides$drug_drug_interactions 1706 13 216.6 Kb + diff --git a/tests/testthat/test_merge_functions.R b/tests/testthat/test_merge_functions.R index 69be241..e85b6cf 100644 --- a/tests/testthat/test_merge_functions.R +++ b/tests/testthat/test_merge_functions.R @@ -1,9 +1,7 @@ context("test different merge functions") +local_edition(3) -test_that( - desc = "merge drugbank and onside", - code = { - local_edition(3) +test_that("merge drugbank and onside", { drugbank <- readRDS(system.file("two_drugs.RDS", package = "dbparser")) onside <- readRDS(system.file("onside.RDS", @@ -30,5 +28,75 @@ test_that( onsides_db = onside) expect_snapshot(show_dvobject_metadata(all_dbs)) - } -) +}) + + +test_that("merge drugbank and twoside", { + drugbank <- readRDS(system.file("two_drugs.RDS", + package = "dbparser")) + data_path <- unzip(system.file("twoside_raw.zip", + package = "dbparser")) + twoside <- parseTWOSIDES(twosides_file_path = data_path) + + expect_error(merge_drugbank_twosides( + db_object = list(), + twosides_db = list()), + "`db_object` must contain a valid DrugBank dvobject.") + + invalid_drugbank <- drugbank + invalid_drugbank$drugs$external_identifiers <- NULL + expect_error(merge_drugbank_twosides( + db_object = invalid_drugbank, + twosides_db = list()), + "`drugbank_db` must contain external_identifiers data.") + + expect_error(merge_drugbank_twosides( + db_object = drugbank, + twosides_db = list()), + "`twosides_db` must be a valid dvobject from parseTWOSIDES().") + + all_dbs <- merge_drugbank_twosides( + db_object = drugbank, + twosides_db = twoside) + expect_snapshot(show_dvobject_metadata(all_dbs)) + unlink(data_path, recursive = TRUE) + +}) + + +test_that("merge chain", { + drugbank <- readRDS(system.file("two_drugs.RDS", + package = "dbparser")) + data_path <- unzip(system.file("twoside_raw.zip", + package = "dbparser")) + onside <- readRDS(system.file("onside.RDS", + package = "dbparser")) + twoside <- parseTWOSIDES(twosides_file_path = data_path) + unlink(data_path, recursive = TRUE) + + final_db_1 <- drugbank %>% + merge_drugbank_onsides(onsides_db = onside) %>% + merge_drugbank_twosides(twosides_db = twoside) + + final_db_2 <- drugbank %>% + merge_drugbank_twosides(twosides_db = twoside) %>% + merge_drugbank_onsides(onsides_db = onside) + + expect_all_true(class(final_db_1) %in% class(final_db_2)) + expect_true(length(class(final_db_1)) == length(class(final_db_2))) + + expect_all_true(names(final_db_1) %in% names(final_db_2)) + expect_true(length(names(final_db_1)) == length(names(final_db_2))) + + expect_all_true(names(final_db_1$drugbank) %in% names(final_db_2$drugbank)) + expect_true(length(names(final_db_1$drugbank)) == length(names(final_db_2$drugbank))) + + expect_all_true(names(final_db_1$onsides) %in% names(final_db_2$onsides)) + expect_true(length(names(final_db_1$onsides)) == length(names(final_db_2$onsides))) + + expect_all_true(names(final_db_1$twosides) %in% names(final_db_2$twosides)) + expect_true(length(names(final_db_1$twosides)) == length(names(final_db_2$twosides))) + + expect_all_true(names(final_db_1$integrated_data) %in% names(final_db_2$integrated_data)) + expect_true(length(names(final_db_1$integrated_data)) == length(names(final_db_2$integrated_data))) +}) From 7badf895ca85050e6a6ab728c4db41f6c6289b4e Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Fri, 26 Dec 2025 10:12:45 +0200 Subject: [PATCH 35/57] - Fixed documentation, #176 --- vignettes/drugbank_nside.Rmd | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/vignettes/drugbank_nside.Rmd b/vignettes/drugbank_nside.Rmd index 9ef620c..698859d 100644 --- a/vignettes/drugbank_nside.Rmd +++ b/vignettes/drugbank_nside.Rmd @@ -109,7 +109,7 @@ Using the retrieved RxCUI, we query the onsides slot of our merged object to fin ```{r adverse_events} # 1. Get the ingredient name from vocab_rxnorm_ingredients -ingredient_name <- merged_db$vocab_rxnorm_ingredient_enriched %>% +ingredient_name <- merged_db$integrated_data$vocab_rxnorm_ingredient_enriched %>% filter(rxnorm_id == target_rxcui) %>% pull(rxnorm_name) @@ -207,7 +207,7 @@ mapping_df_2 <- merged_db$integrated_data$DrugBank_RxCUI_Mapping %>% target_rxcui_2 <- mapping_df_2$rxcui[1] # Get ingredient name -ingredient_name_2 <- merged_db$vocab_rxnorm_ingredient_enriched %>% +ingredient_name_2 <- merged_db$integrated_data$vocab_rxnorm_ingredient_enriched %>% filter(rxnorm_id == target_rxcui_2) %>% pull(rxnorm_name) From 9b62a57f400746359b7f3aa9b46b75277a74f34e Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Fri, 26 Dec 2025 10:22:48 +0200 Subject: [PATCH 36/57] - Fixed CMD check warning, #176 --- R/merge_helpers.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index aaec63f..56e99e3 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -192,7 +192,7 @@ merge_drugbank_twosides <- function(db_object, twosides_db) { rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% dplyr::filter(.data$resource == "RxCUI") %>% dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) %>% - dplyr::mutate(rxcui = as.integer(rxcui)) %>% + dplyr::mutate(rxcui = as.integer(.data$rxcui)) %>% dplyr::distinct() # Drug name lookup From 1fd1f54c227f6079a1b6948cabd1bb0c3d2a209d Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Fri, 26 Dec 2025 10:31:19 +0200 Subject: [PATCH 37/57] - Added twosides documentation --- vignettes/drugbank_nside.Rmd | 389 ++++++++++++++--------------------- 1 file changed, 153 insertions(+), 236 deletions(-) diff --git a/vignettes/drugbank_nside.Rmd b/vignettes/drugbank_nside.Rmd index 698859d..aa9a6a1 100644 --- a/vignettes/drugbank_nside.Rmd +++ b/vignettes/drugbank_nside.Rmd @@ -1,8 +1,8 @@ --- -title: "Integrating DrugBank and OnSIDES with dbparser for Pharmacovigilance Analysis" +title: "Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES" output: rmarkdown::html_vignette vignette: > - %\VignetteIndexEntry{Integrating DrugBank and OnSIDES for Pharmacovigilance Analysis} + %\VignetteIndexEntry{Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES} %\VignetteEngine{knitr::rmarkdown} %\VignetteEncoding{UTF-8} --- @@ -18,11 +18,15 @@ knitr::opts_chunk$set( ## Introduction -In modern pharmacovigilance, the ability to link a drug's molecular mechanism of action with real-world adverse event data is crucial. **DrugBank** provides rich data on drug targets, enzymes, and pathways, while **OnSIDES** provides a massive database of adverse drug events extracted from FDA drug labels. +In modern pharmacovigilance, analyzing drugs in isolation is often insufficient. Patients frequently take multiple medications, leading to complex **Drug-Drug Interactions (DDIs)**. -The `dbparser` package now bridges these two worlds. This vignette demonstrates how to use the new `merge_drugbank_onsides()` function to create an integrated dataset, using the `show_dvobject_metadata()` function to inspect the data structure at every step. +The `dbparser` package now provides a unified framework to analyze the complete safety profile of a drug: -We will perform a scientific case study on **Leuprolide**, linking its biological target to its reported real-world side effects. +1. **Mechanism:** Biological targets and pathways from **DrugBank**. +2. **Phenotype (Single Drug):** Real-world adverse events from **OnSIDES**. +3. **Polypharmacy (Combinations):** Interaction risks from **TWOSIDES**. + +This vignette demonstrates the complete workflow: loading all three databases, merging them into a single `dvobject`, and performing a scientific case study on the interaction between **Leuprolide** and **Calcitriol**. ## Prerequisites @@ -36,15 +40,12 @@ library(data.table) ## 1. Loading and Inspecting Data -To demonstrate the functionality, we will use the curated sample data files included in the dbparser package. +We will use the curated sample data files included in the `dbparser` package to demonstrate the workflow. -### 1.1 Load DrugBank Data -First, we load the DrugBank sample (two_drugs.RDS) and inspect its metadata to verify the presence of mechanistic data (targets, enzymes, etc.). +### 1.1 Load DrugBank (The Hub) +First, we load the mechanistic data. ```{r load_drugbank} -# In a real analysis: -# drugbank_db <- parseDrugBank("path/to/drugbank.xml") -# # Load sample DrugBank data included in the package drugbank_path <- system.file("two_drugs.RDS", package = "dbparser") drugbank_db <- readRDS(drugbank_path) @@ -53,13 +54,10 @@ drugbank_db <- readRDS(drugbank_path) show_dvobject_metadata(drugbank_db) ``` -### 1.2 Load OnSIDES Data - -Next, we load the OnSIDES sample (onside.RDS). This contains the raw label and adverse effect tables. - +### 1.2 Load OnSIDES (Single-Drug Labels) +Next, we load the adverse event data extracted from FDA labels. ```{r load_onside} -# onsides_db <- parseOnSIDES("path/to/onsides_csvs/") # Load sample OnSIDES data included in the package onsides_path <- system.file("onside.RDS", package = "dbparser") onsides_db <- readRDS(onsides_path) @@ -68,85 +66,88 @@ onsides_db <- readRDS(onsides_path) show_dvobject_metadata(onsides_db) ``` +### 1.3 Load TWOSIDES (Drug Interactions) +Finally, we load the dataset containing adverse events reported when two drugs are taken simultaneously. + +```{r load_twosides} +# Load sample TWOSIDES data included in the package +twosides_path <- system.file("twoside_raw.zip", package = "dbparser") + +if(file.exists(twosides_path)) { + twosides_db <- parseTWOSIDES(twosides_path) +} else { + # Fallback for demonstration if file is not yet in the build + # Mocking structure similar to actual TWOSIDES output + twosides_db <- list(drug_drug_interactions = data.table( + drug_1_rxnorm_id = "42375", drug_1_concept_name = "Leuprolide", + drug_2_rxnorm_id = "1894", drug_2_concept_name = "Calcitriol", + condition_meddra_id = "10002034", condition_concept_name = "Anaemia", + PRR = "13.33", mean_reporting_frequency = "0.12" + )) + class(twosides_db) <- c("TWOSIDESDb", "dvobject", "list") + attr(twosides_db, "original_db_info") <- list(type="TWOSIDES", version="2.0") +} -## 2. Merging the Databases +# Review structure +show_dvobject_metadata(twosides_db) +``` -We now use `merge_drugbank_onsides()` to fuse these two objects. This function automatically generates a mapping layer (using RxNorm CUIs) to link DrugBank IDs to OnSIDES label IDs. +## 2. Merging the Databases (Chaining) -```{r merging_dbs} -# Create the merged database object -merged_db <- merge_drugbank_onsides(drugbank_db, onsides_db) +We integrate the databases in a chain. First, we merge OnSIDES into DrugBank, and then we merge TWOSIDES into the result. This creates a single "Hub and Spoke" object centered on DrugBank. -# Review merged_db object using 'show_dvobject_metadata' method -# Note the appearance of 'integrated_data' and 'vocab_rxnorm_ingredients' -show_dvobject_metadata(merged_db) -``` +```{r merging_dbs} +# Step 1: Merge DrugBank + OnSIDES +db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) -> Note: The `integrated_data` slot contains the `DrugBank_RxCUI_Mapping` table, which acts as the "bridge" allowing us to cross from biological mechanisms to clinical side effects. +# Step 2: Merge Result + TWOSIDES +# The function is chainable and automatically detects the existing data +final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) -## 3. Scientific Case Study: Leuprolide (DB00007) +# Review final object structure +# Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' +show_dvobject_metadata(final_db) +``` -**Scientific Context:** Leuprolide is a synthetic analog of gonadotropin-releasing hormone (GnRH). We want to extract its real-world adverse events from OnSIDES and correlate them with its identification in DrugBank. +## 3. Single Drug Analysis: Leuprolide (DB00007) -### 3.1 Retrieve the Cross-Reference Key -We start by finding the link between the DrugBank ID (`DB00007`) and the RxNorm ID required to search the OnSIDES tables +**Scientific Context:** Leuprolide is a GnRH analog. We first establish its baseline side effect profile from OnSIDES. ```{r find_link} target_drug_id <- "DB00007" # Leuprolide -# Access the mapping generated by the merge function -mapping_df <- merged_db$integrated_data$DrugBank_RxCUI_Mapping %>% +# 1. Get the RxNorm ID from the bridge table +mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id) target_rxcui <- mapping_df$rxcui[1] - print(paste0("DrugBank ID: ", target_drug_id, " maps to RxNorm CUI: ", target_rxcui)) ``` -### 3.2 Extract Adverse Events - -Using the retrieved RxCUI, we query the onsides slot of our merged object to find relevant labels and aggregate side effects. +### 3.1 Extract Baseline Adverse Events (OnSIDES) ```{r adverse_events} -# 1. Get the ingredient name from vocab_rxnorm_ingredients -ingredient_name <- merged_db$integrated_data$vocab_rxnorm_ingredient_enriched %>% - filter(rxnorm_id == target_rxcui) %>% - pull(rxnorm_name) - -print(paste("Ingredient name:", ingredient_name)) - -# 2. Find product RxCUIs that contain this ingredient (by name matching) -product_rxcuis <- merged_db$onsides$vocab_rxnorm_ingredient_to_product %>% +# 1. Find product labels linked to this ingredient +product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui) %>% pull(product_id) -print(paste("Found", length(product_rxcuis), "product formulations")) - -# 3. Now link to labels via product_to_rxnorm -target_label_ids <- merged_db$onsides$product_to_rxnorm %>% +target_label_ids <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis) %>% pull(label_id) -print(paste("Found", length(target_label_ids), "labels")) - -# 4. Extract adverse events for these labels -ae_data <- merged_db$onsides$product_adverse_effect %>% - filter(product_label_id %in% target_label_ids) - -print(paste("Total adverse event records:", NROW(ae_data))) - -# 5. Summarize top adverse events by MedDRA ID -ae_summary <- ae_data %>% +# 2. Extract and summarize events +ae_summary <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% - left_join(merged_db$onsides$vocab_meddra_adverse_effect, + left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c("effect_meddra_id" = "meddra_id")) %>% select(effect_meddra_id, meddra_name, Count) -# Handle NAs: For missing MedDRA names, we'll add them manually for top events -# In production, you'd use the complete MedDRA dictionary +# Fill NAs for demo purposes (if vocab is incomplete in sample) ae_summary <- ae_summary %>% mutate(meddra_name = case_when( effect_meddra_id == 10033336 ~ "Pain", @@ -161,220 +162,136 @@ ae_summary <- ae_summary %>% print(ae_summary) ``` +## 4. Single Drug Analysis: Calcitriol (DB00136) -### 3.3 Retrieve Mechanistic Context -To complete the analysis, we pull the biological targets of Leuprolide from the drugbank slot. - -```{r context} -targets <- merged_db$drugbank$cett$targets$general_information %>% - filter(drugbank_id == target_drug_id) %>% - select(name) - -print(paste("Mechanism Target:", targets$name[1])) -``` - - -### 3.4 Visualization -Finally, we use canvasXpress to visualize the side effect profile. This plot represents the seamless integration of data: selecting a drug by its DrugBank ID (Mechanism) and viewing its OnSIDES (Phenotype) data. - -```{r visualization} -cx_data <- data.frame(Count = ae_summary$Count) -rownames(cx_data) <- ae_summary$Adverse_Event - -canvasXpress( - data = t(cx_data), - graphType = "Bar", - title = "Integrated Analysis: Leuprolide (DB00007)", - subtitle = paste("Mechanism:", targets$name[1]), - xAxisTitle = "Frequency in OnSIDES Labels", - yAxisTitle = "Adverse Event", - showLegend = FALSE -) -``` - - -## 4. Second Scientific Case Study: Leuprolide (DB00007) -Let's analyze the second drug in our sample data to demonstrate reproducibility. +We repeat the process for Calcitriol to establish its baseline. ```{r second_case} -# Analyze Calcitriol (Vitamin D analog) target_drug_id_2 <- "DB00136" # Get RxCUI -mapping_df_2 <- merged_db$integrated_data$DrugBank_RxCUI_Mapping %>% +mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id_2) - target_rxcui_2 <- mapping_df_2$rxcui[1] -# Get ingredient name -ingredient_name_2 <- merged_db$integrated_data$vocab_rxnorm_ingredient_enriched %>% - filter(rxnorm_id == target_rxcui_2) %>% - pull(rxnorm_name) - -print(paste("Analyzing:", ingredient_name_2)) - -# Get products -product_rxcuis_2 <- merged_db$onsides$vocab_rxnorm_ingredient_to_product %>% +# Get Products & Labels +product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui_2) %>% pull(product_id) - -# Get labels -target_label_ids_2 <- merged_db$onsides$product_to_rxnorm %>% +target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis_2) %>% pull(label_id) -# Extract adverse events -ae_data_2 <- merged_db$onsides$product_adverse_effect %>% - filter(product_label_id %in% target_label_ids_2) - -# Summarize -ae_summary_2 <- ae_data_2 %>% +# Summarize Events +ae_summary_2 <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids_2) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% - left_join(merged_db$onsides$vocab_meddra_adverse_effect, + left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c("effect_meddra_id" = "meddra_id")) %>% - select(effect_meddra_id, meddra_name, Count) + select(effect_meddra_id, meddra_name, Count) %>% + mutate(meddra_name = ifelse(is.na(meddra_name), paste0("MedDRA_", effect_meddra_id), meddra_name)) %>% + rename(Adverse_Event = meddra_name) +``` -# Fill NAs if needed -ae_summary_2 <- ae_summary_2 %>% - mutate(meddra_name = case_when( - is.na(meddra_name) ~ paste0("MedDRA_", effect_meddra_id), - TRUE ~ meddra_name - )) +## 5. Polypharmacy Analysis: Drug-Drug Interactions -print(ae_summary_2) +**New Insight:** What happens when **Leuprolide** and **Calcitriol** are taken together? -# Get target info -targets_2 <- merged_db$drugbank$cett$targets$general_information %>% - filter(drugbank_id == target_drug_id_2) %>% - select(name) +We query the `integrated_data$drug_drug_interactions` table, which was populated by `merge_drugbank_twosides`. This table allows us to look up interactions by DrugBank ID, using the enriched columns provided by the merge. -print(paste("Primary Target:", targets_2$name[1])) +```{r interaction_analysis} +# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) +interaction_data <- final_db$integrated_data$drug_drug_interactions %>% + filter( + (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | + (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) + ) %>% + arrange(desc(as.numeric(PRR))) %>% + select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) + +print(interaction_data) ``` -## 5. Comparative Analysis +### 5.1 Visualization of Interaction Risks + +We can visualize the specific adverse events associated with this combination, ranked by their **Proportional Reporting Ratio (PRR)** (a measure of signal strength). + +```{r viz_interaction} +if(nrow(interaction_data) > 0) { + # Prepare data for canvasXpress + cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) + rownames(cx_int_data) <- interaction_data$condition_concept_name + + canvasXpress( + data = t(cx_int_data), + graphType = "Bar", + title = "Polypharmacy Risks: Leuprolide + Calcitriol", + subtitle = "Data from TWOSIDES", + xAxisTitle = "Signal Strength (PRR)", + yAxisTitle = "Adverse Event", + showLegend = FALSE + ) +} else { + print("No interaction data found for this specific pair in the sample dataset.") +} +``` -Now let's compare the adverse event profiles of both drugs side-by-side. +## 6. Comparative Overview + +Finally, we can view the single-drug profiles alongside the interaction profile to see if new risks emerge. ```{r comparative_analysis} -# Prepare comparison data - handle NAs in names first -ae_summary <- ae_summary %>% - mutate(Adverse_Event = ifelse(is.na(Adverse_Event) | Adverse_Event == "NA", - paste0("Unknown_", effect_meddra_id), - Adverse_Event)) %>% - mutate(Drug = "Leuprolide") %>% - select(Adverse_Event, Count, Drug) - -ae_summary_2 <- ae_summary_2 %>% - mutate(meddra_name = ifelse(is.na(meddra_name) | meddra_name == "NA", - paste0("Unknown_", effect_meddra_id), - meddra_name)) %>% - rename(Adverse_Event = meddra_name) %>% - mutate(Drug = "Calcitriol") %>% - select(Adverse_Event, Count, Drug) - -# Combine and select top 5 for each drug -combined_ae <- bind_rows(ae_summary, ae_summary_2) %>% - group_by(Drug) %>% - slice_max(Count, n = 5) %>% +# 1. Prepare Single Drug Data +s1 <- ae_summary %>% + mutate(Type = "Leuprolide (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +s2 <- ae_summary_2 %>% + mutate(Type = "Calcitriol (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +# 2. Prepare Interaction Data (Show Top 5) +# Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, +# so we visualize them to show relative importance within their own context. +s3 <- interaction_data %>% + head(5) %>% + mutate(Type = "Interaction (PRR)", Value = as.numeric(PRR)) %>% + select(Adverse_Event = condition_concept_name, Value, Type) + +# 3. Combine +combined_data <- bind_rows(s1, s2, s3) %>% + group_by(Type) %>% + slice_max(Value, n = 5) %>% ungroup() -# Reshape for canvasXpress -comparison_matrix <- combined_ae %>% - pivot_wider(names_from = Drug, values_from = Count, values_fill = 0) +# 4. Reshape for Matrix +comparison_matrix <- combined_data %>% + pivot_wider(names_from = Type, values_from = Value, values_fill = 0) -# Create matrix format cx_compare <- as.data.frame(comparison_matrix[, -1]) rownames(cx_compare) <- comparison_matrix$Adverse_Event -print(cx_compare) - - -# Visualization +# 5. Plot canvasXpress( data = cx_compare, - graphType = "BarLine", - title = "Comparative Adverse Event Profiles", - subtitle = "Leuprolide vs Calcitriol", - xAxisTitle = "Frequency", + graphType = "Bar", + title = "Safety Profile Comparison", + subtitle = "Single Drug Frequencies vs. Interaction PRR", + xAxisTitle = "Value", yAxisTitle = "Adverse Event", - legendPosition = "topRight" + legendPosition = "right" ) ``` -## 7. Statistical Enrichment Analysis -Let's identify which adverse events are significantly enriched in drugs targeting specific protein families. - -```{r enrichment_analysis} -# Get all drugs with target information -all_targets <- merged_db$drugbank$cett$targets$general_information %>% - select(drugbank_id, name, organism) - -# Simplify target names to protein families -all_targets <- all_targets %>% - mutate(protein_family = case_when( - grepl("receptor", name, ignore.case = TRUE) ~ "Receptor", - grepl("enzyme", name, ignore.case = TRUE) ~ "Enzyme", - grepl("transporter", name, ignore.case = TRUE) ~ "Transporter", - TRUE ~ "Other" - )) - -# For this example, let's focus on the "Receptor" class -receptor_drugs <- all_targets %>% - filter(protein_family == "Receptor") %>% - pull(drugbank_id) %>% - unique() - -print(paste("Found", length(receptor_drugs), "drugs targeting receptors")) +## 7. Conclusion -# Get all adverse events for receptor-targeting drugs -receptor_rxcui <- merged_db$integrated_data$DrugBank_RxCUI_Mapping %>% - filter(drugbank_id %in% receptor_drugs) %>% - pull(rxcui) - -# Map to products and labels -receptor_products <- merged_db$onsides$vocab_rxnorm_ingredient_to_product %>% - filter(ingredient_id %in% receptor_rxcui) %>% - pull(product_id) - -receptor_labels <- merged_db$onsides$product_to_rxnorm %>% - filter(rxnorm_product_id %in% receptor_products) %>% - pull(label_id) - -# Get adverse events -receptor_ae_data <- merged_db$onsides$product_adverse_effect %>% - filter(product_label_id %in% receptor_labels) - -# Calculate enrichment (frequency comparison) -receptor_ae_summary <- receptor_ae_data %>% - group_by(effect_meddra_id) %>% - summarise(Receptor_Count = n()) %>% - arrange(desc(Receptor_Count)) %>% - head(10) %>% - left_join(merged_db$onsides$vocab_meddra_adverse_effect, - by = c("effect_meddra_id" = "meddra_id")) %>% - mutate(meddra_name = ifelse(is.na(meddra_name), - paste0("MedDRA_", effect_meddra_id), - meddra_name)) - -print(receptor_ae_summary) - -# Visualize enriched adverse events -cx_enrichment <- data.frame(Count = receptor_ae_summary$Receptor_Count) -rownames(cx_enrichment) <- receptor_ae_summary$meddra_name - -canvasXpress( - data = t(cx_enrichment), - graphType = "Bar", - title = "Enriched Adverse Events: Receptor-Targeting Drugs", - xAxisTitle = "Frequency Across All Receptor Drugs", - yAxisTitle = "Adverse Event", - showLegend = FALSE -) -``` +This analysis highlights the power of the `dbparser` integration ecosystem: -## 8. Conclusion -This vignette demonstrated the power of the merge_drugbank_onsides() function for integrating mechanistic and real-world pharmacovigilance data +1. **DrugBank** provided the identity and mechanism of Leuprolide and Calcitriol. +2. **OnSIDES** quantified their individual side effects (e.g., Pain, Hot Flushes). +3. **TWOSIDES** revealed specific risks when the drugs are combined (e.g., Anaemia). +By chaining `merge_drugbank_onsides` and `merge_drugbank_twosides`, researchers can perform comprehensive safety assessments across mechanistic, real-world, and polypharmacy domains in just a few lines of R code. From e6ad2222a86147d1c506e9f7235dd71d1e80c40f Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 12:08:04 +0200 Subject: [PATCH 38/57] - Updated readme, #185 --- README.Rmd | 60 ++++++++++++++++++++++++++++++---- README.md | 96 ++++++++++++++++++++++++++++++++++++++++++------------ 2 files changed, 129 insertions(+), 27 deletions(-) diff --git a/README.Rmd b/README.Rmd index 4cde390..307df3b 100644 --- a/README.Rmd +++ b/README.Rmd @@ -28,32 +28,44 @@ library(ggplot2) ## Overview Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only -two databases together such as [DrugBank](https://go.drugbank.com/) and [KEGG](https://www.genome.jp/kegg/). +two databases together such as [DrugBank](https://go.drugbank.com/), [OnSIDES](https://onsidesdb.org/), and [TWOSIDES](https://tatonettilab.org/resources/nsides/). -Hence, `dbparser` package aims to parse different public drugs databases as [DrugBank](https://go.drugbank.com/) or [KEGG](https://www.genome.jp/kegg/) into +Hence, `dbparser` package aims to parse different public drugs databases into a single and unified format R object called `dvobject` (stands for drugverse object). +With recent updates, `dbparser` has evolved into an **integration engine**, allowing you to merge mechanistic data (DrugBank) with real-world phenotypic data (OnSIDES) and drug-drug interaction risks (TWOSIDES). + That should help in: - working with single data object and not multiple databases in different formats, - using R analysis capabilities easily on drugs data, - ease of transferring data between researchers after performing required data -analysis or `dvobject` and storing results in the same object in a very easy manner +analysis or `dvobject` and storing results in the same object in a very easy manner. ### dvobject Structure `dvobject` introduces a unified and compressed format of drugs data. -It is an R list object that contains one or more of the following sub-lists: +It is an R list object. +**For a single database (e.g., DrugBank):** +It contains one or more of the following sub-lists: - **drugs**: list of data.frames that contain drugs information (i.e. synonyms, classifications, ...) and it is the only mandatory list - **salts**: data.frame contains drugs salts information - **products**: data.frame of commercially available drugs products in the world - **references**: data.frame of articles, links and textbooks about drugs or CETT data - **cett**: list of data.frames contain targets, enzymes, carriers and transporters information +**For a merged database (Integrated Pharmacovigilance):** +When databases are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, the `dvobject` becomes a nested structure containing: +- **drugbank**: The mechanistic hub. +- **onsides**: The side-effect data (from FDA labels). +- **twosides**: The drug-drug interaction data. +- **integrated_data**: Enriched tables that bridge the databases (e.g., linking DrugBank IDs to OnSIDES adverse events). +- **metadata**: Detailed provenance for all contained datasets. + ## Drug Databases Parsers are available for the following databases (it is in progress list) -### DrugBank +### 1. DrugBank [DrugBank](https://go.drugbank.com/) database is a comprehensive, freely accessible, online database containing information on drugs and drug @@ -72,7 +84,7 @@ The `dbparser` package parses the DrugBank XML database into `R` tibbles that ca If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the `dbdataset` -[package](https://interstellar-consultation-services.github.io/dbdataset/), which contains +[package](https://interstellar-egypt.github.io/dbdataset/), which contains the DrugBank database already parsed into `dvobject`. Note that this is a large package that exceeds the limit set by CRAN. It is only available on GitHub. @@ -81,6 +93,42 @@ successfully. If you find errors with these versions or any other version please submit an issue [here](https://github.com/ropensci/dbparser/issues). +### 2. OnSIDES (The Phenotype) +[OnSIDES](https://onsidesdb.org/) provides adverse drug events extracted from thousands of FDA drug labels using machine learning. +* **Parser:** `parseOnSIDES()` +* **Input:** Directory containing OnSIDES CSV files. + +### 3. TWOSIDES (Polypharmacy) +[TWOSIDES](https://tatonettilab.org/resources/nsides/) provides data on drug-drug interactions and the adverse events that arise when two drugs are taken together. +* **Parser:** `parseTWOSIDES()` +* **Input:** The `TWOSIDES.csv.gz` file. + +## Quick Start: Integration Pipeline + +The power of `dbparser` lies in its ability to chain parsers and mergers together. Here is how you can build a complete pharmacovigilance dataset: + +```r +library(dbparser) +library(dplyr) + +# 1. Parse the raw databases +drugbank_db <- parseDrugBank("data/drugbank.xml") +onsides_db <- parseOnSIDES("data/onsides/") +twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz") + +# 2. Build the Integrated Knowledge Graph +# DrugBank serves as the hub. We chain the merges. +final_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# 3. Analyze Results +# Example: Accessing the enriched drug-drug interaction table +head(final_db$integrated_data$drug_drug_interactions) +``` + +For a detailed case study, please refer to the [Integrated Pharmacovigilance Vignette](https://docs.ropensci.org/dbparser/articles/integrated_pharmacovigilance.html). + ## Installation You can install the released version of dbparser from diff --git a/README.md b/README.md index 36f84ee..2248c03 100644 --- a/README.md +++ b/README.md @@ -22,13 +22,17 @@ Practices](https://bestpractices.coreinfrastructure.org/projects/3311/badge)](ht Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only two databases together such as -[DrugBank](https://go.drugbank.com/) and -[KEGG](https://www.genome.jp/kegg/). +[DrugBank](https://go.drugbank.com/), [OnSIDES](https://onsidesdb.org/), +and [TWOSIDES](https://tatonettilab.org/resources/nsides/). Hence, `dbparser` package aims to parse different public drugs databases -as [DrugBank](https://go.drugbank.com/) or -[KEGG](https://www.genome.jp/kegg/) into single and unified format R -object called `dvobject` (stands for drugverse object). +into a single and unified format R object called `dvobject` (stands for +drugverse object). + +With recent updates, `dbparser` has evolved into an **integration +engine**, allowing you to merge mechanistic data (DrugBank) with +real-world phenotypic data (OnSIDES) and drug-drug interaction risks +(TWOSIDES). That should help in: @@ -37,30 +41,37 @@ That should help in: - using R analysis capabilities easily on drugs data, - ease of transferring data between researchers after performing required data analysis or `dvobject` and storing results in the same - object in a very easy manner + object in a very easy manner. ### dvobject Structure `dvobject` introduces a unified and compressed format of drugs data. It -is an R list object that contains one or more of the following -sub-lists: - -- **drugs**: list of data.frames that contain drugs information - (i.e. synonyms, classifications, …) and it is the only mandatory list -- **salts**: data.frame contains drugs salts information -- **products**: data.frame of commercially available drugs products in - the world -- **references**: data.frame of articles, links and textbooks about - drugs or CETT data -- **cett**: list of data.frames contain targets, enzymes, carriers and - transporters information +is an R list object. + +**For a single database (e.g., DrugBank):** It contains one or more of +the following sub-lists: - **drugs**: list of data.frames that contain +drugs information (i.e. synonyms, classifications, …) and it is the only +mandatory list - **salts**: data.frame contains drugs salts +information - **products**: data.frame of commercially available drugs +products in the world - **references**: data.frame of articles, links +and textbooks about drugs or CETT data - **cett**: list of data.frames +contain targets, enzymes, carriers and transporters information + +**For a merged database (Integrated Pharmacovigilance):** When databases +are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, +the `dvobject` becomes a nested structure containing: - **drugbank**: +The mechanistic hub. - **onsides**: The side-effect data (from FDA +labels). - **twosides**: The drug-drug interaction data. - +**integrated_data**: Enriched tables that bridge the databases (e.g., +linking DrugBank IDs to OnSIDES adverse events). - **metadata**: +Detailed provenance for all contained datasets. ## Drug Databases Parsers are available for the following databases (it is in progress list) -### DrugBank +### 1. DrugBank [DrugBank](https://go.drugbank.com/) database is a comprehensive, freely accessible, online database containing information on drugs and drug @@ -93,6 +104,49 @@ successfully. If you find errors with these versions or any other version please submit an issue [here](https://github.com/ropensci/dbparser/issues). +### 2. OnSIDES (The Phenotype) + +[OnSIDES](https://onsidesdb.org/) provides adverse drug events extracted +from thousands of FDA drug labels using machine learning. \* **Parser:** +`parseOnSIDES()` \* **Input:** Directory containing OnSIDES CSV files. + +### 3. TWOSIDES (Polypharmacy) + +[TWOSIDES](https://tatonettilab.org/resources/nsides/) provides data on +drug-drug interactions and the adverse events that arise when two drugs +are taken together. \* **Parser:** `parseTWOSIDES()` \* **Input:** The +`TWOSIDES.csv.gz` file. + +## Quick Start: Integration Pipeline + +The power of `dbparser` lies in its ability to chain parsers and mergers +together. Here is how you can build a complete pharmacovigilance +dataset: + +``` r +library(dbparser) +library(dplyr) + +# 1. Parse the raw databases +drugbank_db <- parseDrugBank("data/drugbank.xml") +onsides_db <- parseOnSIDES("data/onsides/") +twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz") + +# 2. Build the Integrated Knowledge Graph +# DrugBank serves as the hub. We chain the merges. +final_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# 3. Analyze Results +# Example: Accessing the enriched drug-drug interaction table +head(final_db$integrated_data$drug_drug_interactions) +``` + +For a detailed case study, please refer to the [Integrated +Pharmacovigilance +Vignette](https://docs.ropensci.org/dbparser/articles/integrated_pharmacovigilance.html). + ## Installation You can install the released version of dbparser from @@ -134,7 +188,7 @@ citation("dbparser") #> To cite dbparser in publications use: #> #> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. -#> R package version 2.0.3. +#> R package version 2.1.0.9002. #> #> A BibTeX entry for LaTeX users is #> @@ -142,7 +196,7 @@ citation("dbparser") #> title = {DrugBank Database XML Parser}, #> author = {Mohammed Ali and Ali Ezzat}, #> organization = {Interstellar for Consultinc inc.}, -#> note = {R package version 2.0.3}, +#> note = {R package version 2.1.0.9002}, #> url = {https://CRAN.R-project.org/package=dbparser}, #> } ``` From 6f8b661290d330a9d326614e01b0dcc1a3a52c7b Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 12:32:54 +0200 Subject: [PATCH 39/57] - Updated NEWS, #185 --- NEWS.md | 55 ++++++++++++++++++++++++++++++++++++++++++++++++++++++- 1 file changed, 54 insertions(+), 1 deletion(-) diff --git a/NEWS.md b/NEWS.md index 700c5cb..bd764bc 100644 --- a/NEWS.md +++ b/NEWS.md @@ -1,4 +1,57 @@ -# dbparser (development version) +# dbparser + +# dbparser 2.2.0 + +This is a major feature release focused on expanding `dbparser`'s capabilities into real-world pharmacovigilance and drug-drug interaction analysis. The integration engine has been formalized around a "Hub and Spoke" model, with DrugBank acting as the central hub. + +## NEW FEATURES + +* **New Parser: `parseOnSIDES()`** + * Parses the relational CSV files from the OnSIDES database, a modern resource for adverse drug events extracted from FDA labels. + * Returns a `dvobject` containing the 7 core relational tables and an optional `high_confidence` summary table. + +* **New Parser: `parseTWOSIDES()`** + * Parses the TWOSIDES database, the leading resource for drug-drug interaction (DDI) adverse event signals from real-world data. + * Returns a `dvobject` containing the `drug_drug_interactions` table. + * The parser correctly handles known column name misspellings in the source data (e.g., `drug_1_rxnorn_id`). + +* **New Integration Function: `merge_drugbank_onsides()`** + * Merges a DrugBank `dvobject` with an OnSIDES `dvobject`. + * Automatically creates an enriched `integrated_data` list, linking OnSIDES data to DrugBank IDs via RxNorm CUIs. + * The function is **chainable**, meaning it can be used in a `%>%` pipeline after other merge functions. + +* **New Integration Function: `merge_drugbank_twosides()`** + * Merges a DrugBank `dvobject` with a TWOSIDES `dvobject`. + * Performs a "double join" to enrich both drugs in an interaction pair with their DrugBank IDs and names. + * Uses a robust "union" logic to keep interactions even if only one of the two drugs is present in the input DrugBank object. + * The function is also **chainable**. +* **Subset a DrugBank dvobject function: `subset_drugbank_dvobject()`** + * Intelligently filters a DrugBank dvobject to retain only the data associated with a specified list of drugbank_ids. It correctly handles the deep, +multi-level nested structure of the entire object, including the complex relationships within the `cett` list. +* **Subset an OnSIDES dvobject function: `subset_onsides_dvobject()`** + * Intelligently filters an OnSIDES dvobject by cascading filters through the +relational tables, ensuring the final subset is self-consistent. +* **Adding metadata to existing `dvobject` objects using function: `add_database_info()`** +* **Major enhancements to function `show_dvobject_metadata()`** + * Displays information about passed dbobject object including basic info, + database metadata, and all data.frames contained within nested lists. + +* Run `vignette("dbparser_2_2", package = "dbparser")` for more info + +## DOCUMENTATION + +* **New Vignette: "Integrated Pharmacovigilance"** + * A comprehensive new tutorial demonstrating a full, three-way integration of DrugBank, OnSIDES, and TWOSIDES. + * Includes a complete scientific case study analyzing single-drug vs. polypharmacy risks. + * Introduces a reproducible example workflow using a pre-computed RDS data object hosted externally to keep the package lightweight. + * Run `vignette("drugbank_nside", package = "dbparser")` for more info +* Updated existing vignette and package Readme with enhanced examples + +## BUG FIXES & MINOR IMPROVEMENTS + +* Several minor fixes are done + +--- # dbparser 2.0.3 From c69840cb4eb08cf92ee7f0b40f3458c4f5c78424 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 13:31:35 +0200 Subject: [PATCH 40/57] - Added dbparser vignettes, #185 --- vignettes/dbparser_2_2.Rmd | 55 ++++++++++++++++++++++++++++++++++++++ 1 file changed, 55 insertions(+) create mode 100644 vignettes/dbparser_2_2.Rmd diff --git a/vignettes/dbparser_2_2.Rmd b/vignettes/dbparser_2_2.Rmd new file mode 100644 index 0000000..875e6d0 --- /dev/null +++ b/vignettes/dbparser_2_2.Rmd @@ -0,0 +1,55 @@ +--- +title: "Introducing dbparser 2.2.0" +output: rmarkdown::html_vignette +vignette: > + %\VignetteIndexEntry{Introducing dbparser 2.2.0} + %\VignetteEngine{knitr::rmarkdown} + %\VignetteEncoding{UTF-8} +--- +Data in computational pharmacology is often siloed. We have databases that tell us *what* a drug is (DrugBank), databases that tell us *what side effects* it causes (OnSIDES), and databases that tell us *how it interacts* with other drugs (TWOSIDES). + +Connecting these silos has historically been a painful process of manual mapping and ad-hoc scripting. Today, we are releasing `dbparser` 2.2.0 to solve this problem once and for all. + +#### The "Hub and Spoke" Architecture + +Version 2.2.0 moves beyond simple XML parsing. We have re-engineered the package around a "Hub and Spoke" integration model: + +* **The Hub:** DrugBank serves as the anchor, providing the stable molecular definitions. +* **The Spokes:** OnSIDES and TWOSIDES provide the phenotypic and clinical layers. + +We introduced specific functions to bridge these worlds. The new `merge_drugbank_onsides()` and `merge_drugbank_twosides()` functions don't just combine lists; they perform intelligent "double joins" and ID mapping (using RxNorm CUIs) to ensure that your molecular data is correctly linked to clinical outcomes. + +#### Pipeline-Ready Pharmacovigilance + +One of our main design goals was usability. The new merge functions are "chainable," meaning they integrate seamlessly with the `tidyverse`. You can now build a massive, multi-domain pharmacovigilance dataset in three lines of R code: + +```r +library(dbparser) +library(dplyr) + +final_db <- parseDrugBank("data/drugbank.xml") %>% + merge_drugbank_onsides(parseOnSIDES("data/onsides/")) %>% + merge_drugbank_twosides(parseTWOSIDES("data/twosides.csv.gz")) +``` + +The result is a unified `dvobject` (DrugVerse Object) that contains mechanistic data, label data, and interaction data, all enriched with common identifiers. + +#### New Tools for Reproducibility + +To support developers and educators, we also exposed our internal subsetting engines (`subset_drugbank_dvobject` and `subset_onsides_dvobject`). These schema-aware functions allow you to slice massive databases into consistent, shareable micro-datasets—perfect for creating unit tests or teaching materials. + +#### A Scientific Case Study + +To demonstrate the power of this new workflow, we included a comprehensive new vignette: **[Integrated Pharmacovigilance](drugbank_nside.html)** + +In this tutorial, we perform a live analysis of **Leuprolide** (a hormone therapy) and **Calcitriol** (Vitamin D). We define their individual side effect profiles using OnSIDES, and then use the new TWOSIDES integration to quantify the specific risks—such as Anaemia—that arise when these two drugs are prescribed together. + +#### Availability + +`dbparser` 2.2.0 is available now. You can install it from GitHub to get the latest features immediately, in case it is not available on CRAN yet. + +```r +devtools::install_github("ropensci/dbparser") +``` + +We look forward to seeing what the community builds with these new capabilities! From 6ccb2c53cb80445184fd5fd68b8a1a0aeb992864 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 13:52:21 +0200 Subject: [PATCH 41/57] - Enhanced dbparser vignettes, #185 --- vignettes/dbparser.Rmd | 144 +++++++++++++++++++++-------------------- 1 file changed, 75 insertions(+), 69 deletions(-) diff --git a/vignettes/dbparser.Rmd b/vignettes/dbparser.Rmd index 6034c82..a7666e2 100644 --- a/vignettes/dbparser.Rmd +++ b/vignettes/dbparser.Rmd @@ -1,10 +1,10 @@ --- -title: "DrugBank Database XML Parser" +title: "Unlocking DrugBank: Parsing and Visualizing Mechanistic Data" author: "Mohammed Ali" date: "`r Sys.Date()`" output: rmarkdown::html_vignette vignette: > - %\VignetteIndexEntry{DrugBank Database XML Parser} + %\VignetteIndexEntry{Unlocking DrugBank: Parsing and Visualizing Mechanistic Data} %\VignetteEngine{knitr::rmarkdown} %\VignetteEncoding{UTF-8} --- @@ -14,125 +14,131 @@ knitr::opts_chunk$set( collapse = TRUE, comment = "#>", fig.path = "docs/articles/", - out.width = "100%" + out.width = "100%", + warning = FALSE, + message = FALSE ) ``` ## Introduction -The main purpose of the `dbparser` package is to parse the -[DrugBank](https://go.drugbank.com/) database which is downloadable in XML format -from [this link](https://go.drugbank.com/releases/latest). The parsed data can -then be explored and analyzed as desired by the user. -In this tutorial, we will see how to use `dbparser` along with `dplyr` and -`ggplot2` along with other libraries to do simple drug analysis -## Loading and Parsing the Data +The **DrugBank** database is the global gold standard for drug information, containing rich data on chemical structures, pharmacology, and molecular targets. However, the raw data is provided as a massive, complex XML file that is difficult to use in statistical analysis. -Before starting the code we are assuming the following: +`dbparser` solves this problem. It transforms that complex XML into a **Drugverse Object (`dvobject`)**—a structured collection of R data frames ready for analysis. -- user already downloaded *DrugBank* xml database file based on the -[Read Me](https://docs.ropensci.org/dbparser/) instructions or the above note, -- user saved the downloaded database in working directory as `C:\`. -- user named the downloaded xml file **drugbank.xml**. +In this tutorial, we will demonstrate how to: -Now we can loads the `drugs` info, `drug groups` info and `drug targets` -actions info. +1. Parse the database. +2. Explore the data structure. +3. Visualize key insights using `dplyr` and `canvasXpress`. -```{r eval=T} -## load dbparser package +## 1. Loading Data + +### The Parsing Workflow +In a real-world scenario, you would parse the full XML database (downloaded from [DrugBank](https://go.drugbank.com/releases/latest)) using `parseDrugBank()`. + +```r +library(dbparser) + +# Parse the full XML file (this creates a dvobject) +# drugbank_db <- parseDrugBank("drugbank_full_database.xml") +``` + +### Loading Sample Data +For this vignette, we will load curated sample datasets included in the package. These represent specific tables that would be found inside the full `dvobject`. + +```{r load_data} suppressPackageStartupMessages({ library(tidyr) library(dplyr) - library(canvasXpress) library(tibble) + library(canvasXpress) library(dbparser) }) - -## load drugs data +# Load sample tables representing parts of the parsed dvobject drugs <- readRDS(system.file("drugs.RDS", package = "dbparser")) - -## load drug groups data drug_groups <- readRDS(system.file("drug_groups.RDS", package = "dbparser")) - -## load drug targets actions data drug_targets_actions <- readRDS(system.file("targets_actions.RDS", package = "dbparser")) ``` +## 2. Analysis: The Drug Landscape -## Exploring the data - -Following is an example involving a quick look at a few aspects of the parsed -data. First we look at the proportions of `biotech` and `small-molecule` drugs -in the data. +What does the universe of approved drugs look like? Let's analyze the composition of the database by drug type (Small Molecule vs. Biotech). -```{r eval=T} -## view proportions of the different drug types (biotech vs. small molecule) +```{r analysis_type} +# Prepare data: Count drugs by type type_stat <- drugs %>% - select(type) %>% group_by(type) %>% - summarise(count = n()) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% column_to_rownames("type") +# Visualize canvasXpress( data = type_stat, - graphOrientation = "vertical", graphType = "Bar", + title = "Composition of DrugBank: Drug Types", showSampleNames = FALSE, - title ="Drugs Type Distribution", - xAxisTitle = "Count" + legendPosition = "right" ) ``` +## 3. Analysis: Approval Status -Below, we view the different `drug_groups` in the data and how prevalent they -are. +Drugs are categorized into groups such as "approved", "investigational", or "experimental". How does the complexity (Biotech vs. Small Molecule) differ across these groups? -```{r eval=T} -## view proportions of the different drug types for each drug group -type_stat <- drugs %>% - full_join(drug_groups, by = c("drugbank_id")) %>% - select(type, group) %>% +```{r analysis_groups} +# Prepare data: Cross-tabulate Type vs Group +group_stat <- drugs %>% + full_join(drug_groups, by = "drugbank_id") %>% group_by(type, group) %>% - summarise(count = n()) %>% - pivot_wider(names_from = group, values_from = count) %>% + summarise(count = n(), .groups = 'drop') %>% + pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% column_to_rownames("type") +# Visualize with a Stacked Bar Chart canvasXpress( - data = type_stat, + data = group_stat, graphType = "Stacked", - legendColumns = 2, + graphOrientation = "horizontal", + title = "Drug Types by Approval Status", + xAxisTitle = "Number of Drugs", legendPosition = "bottom", - title ="Drug Type Distribution per Drug Group", - xAxisTitle = "Quantity", - xAxis2Show = TRUE, - xAxisShow = FALSE, - smpTitle = "Drug Group") + xAxis2Show = FALSE +) ``` -Finally, we look at the `drug_targets_actions` to observe their proportions as -well. +## 4. Analysis: Molecular Mechanisms +One of DrugBank's most valuable features is the detailed information on how drugs interact with their targets (Proteins, Enzymes, etc.). Are drugs mostly inhibitors, agonists, or antagonists? -```{r eval=T} -## get counts of the different target actions in the data -targetActionCounts <- - drug_targets_actions %>% +```{r analysis_targets} +# Prepare data: Top 10 most common Mechanisms of Action +targetActionCounts <- drug_targets_actions %>% group_by(action) %>% - summarise(count = n()) %>% - arrange(desc(count)) %>% - top_n(10) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + slice_head(n = 10) %>% column_to_rownames("action") -## get bar chart of the 10 most occurring target actions in the data +# Visualize canvasXpress( data = targetActionCounts, graphType = "Bar", - legendColumns = 2, - legendPosition = "bottom", - title = "Target Actions Distribution", + graphOrientation = "vertical", + colorBy = "Count", + title = "Top 10 Mechanisms of Action", + xAxisTitle = "Number of Interactions", showSampleNames = FALSE, - xAxis2Show = TRUE, - xAxisShow = FALSE) + legendPosition = "none" +) ``` +## 5. Next Steps: Integrated Pharmacovigilance + +Now that you have mastered the mechanistic data in DrugBank, you can combine it with real-world data! + +`dbparser` now supports **OnSIDES** (Adverse Events) and **TWOSIDES** (Drug-Drug Interactions). + +Check out the **[Integrated Pharmacovigilance Vignette](integrated_pharmacovigilance.html)** to learn how to merge these databases to perform polypharmacy risk analysis. From d442b1d847c0fafd3c0d42cd244ac3c206e4ffa4 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 13:55:02 +0200 Subject: [PATCH 42/57] - Updated package version, #186 --- DESCRIPTION | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/DESCRIPTION b/DESCRIPTION index 5f8f3da..4643dfb 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,6 +1,6 @@ Package: dbparser Title: Drugs Databases Parser -Version: 2.1.0.9002 +Version: 2.2.0 Authors@R: c( person("Mohammed", "Ali", email = "moh_fcis@yahoo.com", role = c("aut", "cre")), From dee750e83c5d34aad92957a1b712f9ab17d3c80c Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 15:15:21 +0200 Subject: [PATCH 43/57] #186, update package website --- R/dvobject_metadata.R | 2 + R/merge_helpers.R | 2 + R/nsides_parsers.R | 1 + R/onsides_parser.R | 1 + R/utils.R | 4 +- README.Rmd | 6 +- README.md | 50 +- _pkgdown.yml | 26 +- docs/404.html | 141 +-- docs/CODE_OF_CONDUCT.html | 109 +- docs/CONTRIBUTING.html | 129 +-- docs/LICENSE-text.html | 108 +- docs/articles/dbparser.html | 335 +++---- docs/articles/index.html | 111 +- docs/authors.html | 139 ++- docs/index.html | 233 +++-- docs/news/index.html | 187 ++-- docs/pkgdown.js | 218 ++-- docs/pkgdown.yml | 12 +- docs/reference/articles.html | 124 +-- docs/reference/attachments.html | 124 +-- docs/reference/books.html | 127 +-- docs/reference/carriers.html | 263 +---- docs/reference/carriers_actions.html | 270 +---- docs/reference/carriers_articles.html | 271 +---- docs/reference/carriers_links.html | 264 +---- docs/reference/carriers_polypeptides_go.html | 278 +---- .../carriers_polypeptides_pfams.html | 272 +---- docs/reference/carriers_polypeptides_syn.html | 274 +---- docs/reference/carriers_textbooks.html | 268 +---- docs/reference/cett_actions_doc.html | 124 +-- docs/reference/cett_doc.html | 128 +-- docs/reference/cett_ex_identity_doc.html | 130 +-- docs/reference/cett_go_doc.html | 130 +-- docs/reference/cett_nodes_options.html | 138 ++- docs/reference/cett_poly_doc.html | 127 +-- docs/reference/cett_poly_pfms_doc.html | 127 +-- docs/reference/cett_poly_syn_doc.html | 127 +-- docs/reference/dbparser.html | 145 ++- docs/reference/drug_affected_organisms.html | 127 +-- docs/reference/drug_ahfs_codes.html | 124 +-- docs/reference/drug_atc_codes.html | 133 +-- docs/reference/drug_calc_prop.html | 128 +-- docs/reference/drug_categories.html | 124 +-- docs/reference/drug_classification.html | 127 +-- docs/reference/drug_dosages.html | 124 +-- docs/reference/drug_ex_identity.html | 127 +-- docs/reference/drug_exp_prop.html | 124 +-- docs/reference/drug_external_links.html | 124 +-- docs/reference/drug_food_interactions.html | 124 +-- docs/reference/drug_general_information.html | 127 +-- docs/reference/drug_groups.html | 127 +-- docs/reference/drug_interactions.html | 129 +-- docs/reference/drug_intern_brand.html | 128 +-- docs/reference/drug_manufacturers.html | 127 +-- docs/reference/drug_mixtures.html | 127 +-- docs/reference/drug_node_options.html | 138 ++- docs/reference/drug_packagers.html | 124 +-- docs/reference/drug_patents.html | 136 +-- docs/reference/drug_pathway.html | 127 +-- docs/reference/drug_pathway_drugs.html | 124 +-- docs/reference/drug_pathway_enzyme.html | 124 +-- docs/reference/drug_pdb_entries.html | 124 +-- docs/reference/drug_pharmacology.html | 127 +-- docs/reference/drug_prices.html | 124 +-- docs/reference/drug_products.html | 127 +-- docs/reference/drug_reactions.html | 130 +-- docs/reference/drug_reactions_enzymes.html | 124 +-- docs/reference/drug_salts.html | 128 +-- docs/reference/drug_sequences.html | 128 +-- .../reference/drug_snp_adverse_reactions.html | 127 +-- docs/reference/drug_snp_effects.html | 128 +-- docs/reference/drug_syn.html | 124 +-- docs/reference/enzymes.html | 261 +---- docs/reference/enzymes_actions.html | 265 +---- docs/reference/enzymes_articles.html | 267 +---- docs/reference/enzymes_links.html | 261 +---- docs/reference/enzymes_textbooks.html | 268 +---- docs/reference/index.html | 249 +++-- docs/reference/init_dvobject.html | 130 +-- docs/reference/links.html | 127 +-- docs/reference/parseDrugBank.html | 160 ++- docs/reference/parse_cett_node.html | 127 +-- docs/reference/parse_drug_nodes.html | 132 +-- docs/reference/parse_references_node.html | 124 +-- docs/reference/read_drugbank_xml_db.html | 139 ++- docs/reference/references_node_options.html | 138 ++- docs/reference/show_dvobject_metadata.html | 167 ++- docs/reference/targets.html | 261 +---- docs/reference/targets_actions.html | 264 +---- docs/reference/targets_articles.html | 267 +---- docs/reference/targets_links.html | 265 +---- docs/reference/targets_textbooks.html | 268 +---- docs/reference/transporters.html | 265 +---- docs/reference/transporters_actions.html | 265 +---- docs/reference/transporters_articles.html | 266 +---- docs/reference/transporters_links.html | 267 +---- .../transporters_polypep_ex_ident.html | 276 +---- docs/reference/transporters_textbooks.html | 272 +---- docs/sitemap.xml | 949 +++++------------- man/add_database_info.Rd | 7 + man/cett_nodes_options.Rd | 1 + man/drug_node_options.Rd | 1 + man/merge_drugbank_onsides.Rd | 5 + man/merge_drugbank_twosides.Rd | 5 + man/parseDrugBank.Rd | 1 + man/parseOnSIDES.Rd | 8 + man/parseTWOSIDES.Rd | 9 + man/references_node_options.Rd | 3 +- man/show_dvobject_metadata.Rd | 7 + man/subset_drugbank_dvobject.Rd | 6 +- man/subset_onsides_dvobject.Rd | 6 +- 112 files changed, 4362 insertions(+), 12237 deletions(-) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index c157525..b790271 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -21,6 +21,7 @@ init_dvobject <- function() { #' @param db_exported_date database official export date #' #' @return dvobject +#' @family utility #' @export #' @importFrom dplyr .data filter select rename mutate left_join add_database_info <- function(dvobject, @@ -56,6 +57,7 @@ add_database_info <- function(dvobject, #' } #' #' @export +#' @family utility #' @importFrom utils object.size show_dvobject_metadata <- function(obj, return_df = FALSE) { # Initialize return variable diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 56e99e3..25f4b3c 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -22,6 +22,7 @@ #' @return A new dvobject containing the integrated data. #' #' @export +#' @family mergers #' @importFrom dplyr filter select rename mutate left_join .data #' #' @examples @@ -160,6 +161,7 @@ merge_drugbank_onsides <- function(db_object, onsides_db) { #' @return A new, nested dvobject with the TWOSIDES data added. #' #' @importFrom dplyr filter select rename mutate left_join .data distinct +#' @family mergers #' @export merge_drugbank_twosides <- function(db_object, twosides_db) { diff --git a/R/nsides_parsers.R b/R/nsides_parsers.R index 118b66f..4f8485c 100644 --- a/R/nsides_parsers.R +++ b/R/nsides_parsers.R @@ -32,6 +32,7 @@ #' data frame and associated metadata. #' #' @export +#' @family parsers #' @importFrom data.table fread parseTWOSIDES <- function(twosides_file_path, db_version = NULL, diff --git a/R/onsides_parser.R b/R/onsides_parser.R index b81a4a9..12678ae 100644 --- a/R/onsides_parser.R +++ b/R/onsides_parser.R @@ -16,6 +16,7 @@ #' @family parsers #' #' @export +#' @family parsers #' @importFrom data.table fread parseOnSIDES <- function(dataDir, include_high_confidence = TRUE, diff --git a/R/utils.R b/R/utils.R index 9492b27..fd8cd70 100644 --- a/R/utils.R +++ b/R/utils.R @@ -71,7 +71,7 @@ subset_cett_component <- function(component, component_name, drug_ids) { #' one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, #' drug_ids = "DB00001") #' } -#' @family utils +#' @family utility subset_drugbank_dvobject <- function(dvobject, drug_ids) { new_dvobject <- NULL @@ -191,7 +191,7 @@ subset_drugbank_dvobject <- function(dvobject, drug_ids) { #' @importFrom dplyr filter pull .data #' #' @return A new, smaller dvobject with the same structure. -#' @family utils +#' @family utility subset_onsides_dvobject <- function(dvobject, ingredient_ids) { new_dvobject <- NULL diff --git a/README.Rmd b/README.Rmd index 307df3b..2747104 100644 --- a/README.Rmd +++ b/README.Rmd @@ -21,9 +21,9 @@ library(ggplot2) [![Project Status: Active – The project has reached a stable, usable state and is being actively developed.](https://www.repostatus.org/badges/latest/active.svg)](https://www.repostatus.org/#active) [![Lifecycle: stable](https://img.shields.io/badge/lifecycle-stable-brightgreen.svg)](https://lifecycle.r-lib.org/articles/stages.html) [![metacran downloads](https://cranlogs.r-pkg.org/badges/grand-total/dbparser)](https://cran.r-project.org/package=dbparser) -[![](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) +[![Rdoc Documentation](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) [![CII Best Practices](https://bestpractices.coreinfrastructure.org/projects/3311/badge)](https://bestpractices.coreinfrastructure.org/projects/3311) -[![](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) +[![rOpenSci Peer-Reviewed](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) ## Overview Drugs databases vary too much in their formats and structures which making related @@ -48,6 +48,7 @@ It is an R list object. **For a single database (e.g., DrugBank):** It contains one or more of the following sub-lists: + - **drugs**: list of data.frames that contain drugs information (i.e. synonyms, classifications, ...) and it is the only mandatory list - **salts**: data.frame contains drugs salts information - **products**: data.frame of commercially available drugs products in the world @@ -56,6 +57,7 @@ It contains one or more of the following sub-lists: **For a merged database (Integrated Pharmacovigilance):** When databases are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, the `dvobject` becomes a nested structure containing: + - **drugbank**: The mechanistic hub. - **onsides**: The side-effect data (from FDA labels). - **twosides**: The drug-drug interaction data. diff --git a/README.md b/README.md index 2248c03..02f0f6b 100644 --- a/README.md +++ b/README.md @@ -12,10 +12,12 @@ developed.](https://www.repostatus.org/badges/latest/active.svg)](https://www.re stable](https://img.shields.io/badge/lifecycle-stable-brightgreen.svg)](https://lifecycle.r-lib.org/articles/stages.html) [![metacran downloads](https://cranlogs.r-pkg.org/badges/grand-total/dbparser)](https://cran.r-project.org/package=dbparser) -[![](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) +[![Rdoc +Documentation](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) [![CII Best Practices](https://bestpractices.coreinfrastructure.org/projects/3311/badge)](https://bestpractices.coreinfrastructure.org/projects/3311) -[![](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) +[![rOpenSci +Peer-Reviewed](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) ## Overview @@ -49,22 +51,28 @@ That should help in: is an R list object. **For a single database (e.g., DrugBank):** It contains one or more of -the following sub-lists: - **drugs**: list of data.frames that contain -drugs information (i.e. synonyms, classifications, …) and it is the only -mandatory list - **salts**: data.frame contains drugs salts -information - **products**: data.frame of commercially available drugs -products in the world - **references**: data.frame of articles, links -and textbooks about drugs or CETT data - **cett**: list of data.frames -contain targets, enzymes, carriers and transporters information +the following sub-lists: + +- **drugs**: list of data.frames that contain drugs information + (i.e. synonyms, classifications, …) and it is the only mandatory list +- **salts**: data.frame contains drugs salts information +- **products**: data.frame of commercially available drugs products in + the world +- **references**: data.frame of articles, links and textbooks about + drugs or CETT data +- **cett**: list of data.frames contain targets, enzymes, carriers and + transporters information **For a merged database (Integrated Pharmacovigilance):** When databases are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, -the `dvobject` becomes a nested structure containing: - **drugbank**: -The mechanistic hub. - **onsides**: The side-effect data (from FDA -labels). - **twosides**: The drug-drug interaction data. - -**integrated_data**: Enriched tables that bridge the databases (e.g., -linking DrugBank IDs to OnSIDES adverse events). - **metadata**: -Detailed provenance for all contained datasets. +the `dvobject` becomes a nested structure containing: + +- **drugbank**: The mechanistic hub. +- **onsides**: The side-effect data (from FDA labels). +- **twosides**: The drug-drug interaction data. +- **integrated_data**: Enriched tables that bridge the databases (e.g., + linking DrugBank IDs to OnSIDES adverse events). +- **metadata**: Detailed provenance for all contained datasets. ## Drug Databases @@ -94,10 +102,10 @@ more details. If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the `dbdataset` -[package](https://interstellar-consultation-services.github.io/dbdataset/), -which contains the DrugBank database already parsed into `dvobject`. -Note that this is a large package that exceeds the limit set by CRAN. It -is only available on GitHub. +[package](https://interstellar-egypt.github.io/dbdataset/), which +contains the DrugBank database already parsed into `dvobject`. Note that +this is a large package that exceeds the limit set by CRAN. It is only +available on GitHub. `dbparser` is tested against DrugBank versions *5.1.0* through *5.1.12* successfully. If you find errors with these versions or any other @@ -188,7 +196,7 @@ citation("dbparser") #> To cite dbparser in publications use: #> #> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. -#> R package version 2.1.0.9002. +#> R package version 2.2.0. #> #> A BibTeX entry for LaTeX users is #> @@ -196,7 +204,7 @@ citation("dbparser") #> title = {DrugBank Database XML Parser}, #> author = {Mohammed Ali and Ali Ezzat}, #> organization = {Interstellar for Consultinc inc.}, -#> note = {R package version 2.1.0.9002}, +#> note = {R package version 2.2.0}, #> url = {https://CRAN.R-project.org/package=dbparser}, #> } ``` diff --git a/_pkgdown.yml b/_pkgdown.yml index 7cbf2dc..d177f4d 100644 --- a/_pkgdown.yml +++ b/_pkgdown.yml @@ -1,17 +1,19 @@ +template: + bootstrap: 5 + bootswatch: flatly + +url: https://docs.ropensci.org/dbparser + navbar: + bg: primary structure: - left: - - home - - intro - - reference - - articles - - tutorials - - news - right: github + left: [intro, reference, articles, news] + right: [search, github] components: home: icon: fas fa-home fa-lg href: index.html + aria-label: "Home" reference: text: Reference href: reference/index.html @@ -21,6 +23,10 @@ navbar: news: text: Changelog href: news/index.html + github: + icon: fab fa-github + href: https://github.com/ropensci/dbparser + aria-label: "GitHub" reference: - title: "Drugs Databases Parser" @@ -31,6 +37,10 @@ reference: desc: "Different functions to handle dvobject" contents: - has_concept("utility") +- title: "Merge functions" + desc: "Different functions to merge different types of dvobjects" + contents: + - has_concept("mergers") authors: Mohammed Ali: diff --git a/docs/404.html b/docs/404.html index f0b3f1a..c5b7e94 100644 --- a/docs/404.html +++ b/docs/404.html @@ -4,116 +4,85 @@ - + Page not found (404) • dbparser - - - - - - - - - - - - - - + + + + + + + + + + + - - - -
-
-
-
-

Page not found (404)

+
+
+
+
+

Page not found (404)

+
Content not found. Please use links in the navbar. -
- - - +
- -
- - + diff --git a/docs/CODE_OF_CONDUCT.html b/docs/CODE_OF_CONDUCT.html index fc4fcc6..4098416 100644 --- a/docs/CODE_OF_CONDUCT.html +++ b/docs/CODE_OF_CONDUCT.html @@ -1,58 +1,40 @@ -Contributor Covenant Code of Conduct • dbparser - - -
-
-
-
-

Contributor Covenant Code of Conduct

+ + + +
+
+
+
+

Contributor Covenant Code of Conduct

+ Source: CODE_OF_CONDUCT.md
@@ -97,30 +79,23 @@

Attribution

- +
-
- - diff --git a/docs/CONTRIBUTING.html b/docs/CONTRIBUTING.html index a5deca6..ca08cad 100644 --- a/docs/CONTRIBUTING.html +++ b/docs/CONTRIBUTING.html @@ -1,58 +1,40 @@ -Contributing to dbparser • dbparser - - -
-
- - - -
-
-
-

Contributing to dbparser

+ +
+
+
+

Contributing to dbparser

+ Source: CONTRIBUTING.md
@@ -68,35 +50,35 @@

Code of conductHow you can contribute

There are several ways you can contribute to this project. If you want to know more about why and how to contribute to open source projects like this one, see this Open Source Guide.

-

Share the love ❤️

+

Share the love ❤️

Think dbparser is useful? Let others discover it, by telling them in person, via Twitter or a blog post.

-

Using dbparser for a paper you are writing? Consider citing it.

+

Using dbparser for a paper you are writing? Consider citing it.

-

Ask a question ⁉️

-

Using our_package and got stuck? Browse the documentation to see if you can find a solution. Still stuck? Post your question as an issue on GitHub. While we cannot offer user support, we’ll try to do our best to address it, as questions often lead to better documentation or the discovery of bugs.

+

Ask a question ⁉️

+

Using our_package and got stuck? Browse the documentation to see if you can find a solution. Still stuck? Post your question as an issue on GitHub. While we cannot offer user support, we’ll try to do our best to address it, as questions often lead to better documentation or the discovery of bugs.

Want to ask a question in private? Contact the package maintainer by email.

-

Propose an idea 💡

-

Have an idea for a new our_package feature? Take a look at the documentation and issue list to see if it isn’t included or suggested yet. If not, suggest your idea as an issue on GitHub. While we can’t promise to implement your idea, it helps to:

+

Propose an idea 💡

+

Have an idea for a new our_package feature? Take a look at the documentation and issue list to see if it isn’t included or suggested yet. If not, suggest your idea as an issue on GitHub. While we can’t promise to implement your idea, it helps to:

  • Explain in detail how it would work.
  • Keep the scope as narrow as possible.

See below if you want to contribute code for your idea as well.

-

Report a bug 🐛

+

Report a bug 🐛

Using our_package and discovered a bug? That’s annoying! Don’t let others have the same experience and report it as an issue on GitHub so we can fix it. A good bug report makes it easier for us to do so, so please include:

  • Your operating system name and version (e.g. Mac OS 10.13.6).
  • Any details about your local setup that might be helpful in troubleshooting.
  • Detailed steps to reproduce the bug.
-

Improve the documentation 📖

+

Improve the documentation 📖

Noticed a typo on the website? Think a function could use a better example? Good documentation makes all the difference, so your help to improve it is very welcome!

The website

-

This website is generated with pkgdown. That means we don’t have to write any html: content is pulled together from documentation in the code, vignettes, Markdown files, the package DESCRIPTION and _pkgdown.yml settings. If you know your way around pkgdown, you can propose a file change to improve documentation. If not, report an issue and we can point you in the right direction.

+

This website is generated with pkgdown. That means we don’t have to write any html: content is pulled together from documentation in the code, vignettes, Markdown files, the package DESCRIPTION and _pkgdown.yml settings. If you know your way around pkgdown, you can propose a file change to improve documentation. If not, report an issue and we can point you in the right direction.

Function documentation

@@ -108,7 +90,7 @@

Function documentation

-

Contribute code 📝

+

Contribute code 📝

Care to fix bugs or implement new functionality for our_package? Awesome! 👏 Have a look at the issue list and leave a comment on the things you want to work on. See also the development guidelines below.

@@ -129,30 +111,23 @@

Development guidelines

-
+
- +
-
- - diff --git a/docs/LICENSE-text.html b/docs/LICENSE-text.html index 3559559..fd539db 100644 --- a/docs/LICENSE-text.html +++ b/docs/LICENSE-text.html @@ -1,88 +1,62 @@ -License • dbparser - - -
-
-
-
-

License

YEAR: 2018
 COPYRIGHT HOLDER: Mohammed Ali, Ali Ezzat
-
+
- +
-
- - diff --git a/docs/articles/dbparser.html b/docs/articles/dbparser.html index d970bc9..309e7dc 100644 --- a/docs/articles/dbparser.html +++ b/docs/articles/dbparser.html @@ -4,94 +4,72 @@ - -DrugBank Database XML Parser • dbparser - - - - - - - - - - - - - - - + +Unlocking DrugBank: Parsing and Visualizing Mechanistic Data • dbparser + + + + + + + + + + - - + + Skip to contents -
-
-
-
-
-

DrugBank Database XML Parser

+ +
+
+

Unlocking DrugBank: Parsing and Visualizing Mechanistic Data

Mohammed Ali

-

2024-04-20

+

2025-12-27

Source: vignettes/dbparser.Rmd - - +
dbparser.Rmd
@@ -99,154 +77,171 @@

2024-04-20

Introduction

-

The main purpose of the dbparser package is to parse the -DrugBank database which is -downloadable in XML format from this link. The parsed -data can then be explored and analyzed as desired by the user. In this -tutorial, we will see how to use dbparser along with -dplyr and ggplot2 along with other libraries -to do simple drug analysis

+

The DrugBank database is the global gold standard +for drug information, containing rich data on chemical structures, +pharmacology, and molecular targets. However, the raw data is provided +as a massive, complex XML file that is difficult to use in statistical +analysis.

+

dbparser solves this problem. It transforms that complex +XML into a Drugverse Object (dvobject)—a +structured collection of R data frames ready for analysis.

+

In this tutorial, we will demonstrate how to:

+
    +
  1. Parse the database.
    2. +
  2. Explore the data structure.
    3. +
  3. Visualize key insights using dplyr and +canvasXpress.
    4. +
-

Loading and Parsing the Data +

1. Loading Data

-

Before starting the code we are assuming the following:

-
    -
  • user already downloaded DrugBank xml database file based on -the Read Me -instructions or the above note,
    • -
  • user saved the downloaded database in working directory as -C:\.
    • -
  • user named the downloaded xml file -drugbank.xml.
    • -
-

Now we can loads the drugs info, -drug groups info and drug targets actions -info.

+
+

The Parsing Workflow +

+

In a real-world scenario, you would parse the full XML database +(downloaded from DrugBank) using +parseDrugBank().

-## load dbparser package
-suppressPackageStartupMessages({
+library(dbparser)
+
+# Parse the full XML file (this creates a dvobject)
+# drugbank_db <- parseDrugBank("drugbank_full_database.xml")
+
+
+

Loading Sample Data +

+

For this vignette, we will load curated sample datasets included in +the package. These represent specific tables that would be found inside +the full dvobject.

+
+suppressPackageStartupMessages({
   library(tidyr)
   library(dplyr)
-  library(canvasXpress)
   library(tibble)
-  library(dbparser)
+  library(canvasXpress)
+  library(dbparser)
 })
 
-
-## load drugs data
+# Load sample tables representing parts of the parsed dvobject
 drugs <- readRDS(system.file("drugs.RDS", package = "dbparser"))
-
-## load drug groups data
 drug_groups <- readRDS(system.file("drug_groups.RDS", package = "dbparser"))
-
-## load drug targets actions data
 drug_targets_actions <- readRDS(system.file("targets_actions.RDS", package = "dbparser"))
+
-

Exploring the data +

2. Analysis: The Drug Landscape

-

Following is an example involving a quick look at a few aspects of -the parsed data. First we look at the proportions of -biotech and small-molecule drugs in the -data.

-
-## view proportions of the different drug types (biotech vs. small molecule)
+
What does the universe of approved drugs look like? Let’s analyze the
+composition of the database by drug type (Small Molecule
+vs. Biotech).

+
+# Prepare data: Count drugs by type
 type_stat <- drugs %>% 
-  select(type) %>% 
   group_by(type) %>% 
-  summarise(count = n()) %>% 
+  summarise(Count = n()) %>% 
+  arrange(desc(Count)) %>% 
   column_to_rownames("type")
 
+# Visualize
 canvasXpress(
   data             = type_stat,
-  graphOrientation = "vertical",
   graphType        = "Bar",
+  title            = "Composition of DrugBank: Drug Types",
   showSampleNames  = FALSE,
-  title            ="Drugs Type Distribution",
-  xAxisTitle       = "Count"
+  legendPosition   = "right"
 )

-

-
Below, we view the different drug_groups in the data and
-how prevalent they are.

-
-## view proportions of the different drug types for each drug group
-type_stat <- drugs %>% 
-  full_join(drug_groups, by = c("drugbank_id")) %>% 
-  select(type, group) %>% 
+

+
+

+

+
3. Analysis: Approval Status
+

+
Drugs are categorized into groups such as “approved”,
+“investigational”, or “experimental”. How does the complexity (Biotech
+vs. Small Molecule) differ across these groups?

+
+# Prepare data: Cross-tabulate Type vs Group
+group_stat <- drugs %>% 
+  full_join(drug_groups, by = "drugbank_id") %>% 
   group_by(type, group) %>% 
-  summarise(count = n()) %>% 
-  pivot_wider(names_from = group, values_from = count) %>% 
+  summarise(count = n(), .groups = 'drop') %>% 
+  pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% 
   column_to_rownames("type")
-#> `summarise()` has grouped output by 'type'. You can override using the
-#> `.groups` argument.
 
+# Visualize with a Stacked Bar Chart
 canvasXpress(
-  data           = type_stat,
+  data           = group_stat,
   graphType      = "Stacked",
-  legendColumns  = 2,
+  graphOrientation = "horizontal",
+  title          = "Drug Types by Approval Status",
+  xAxisTitle     = "Number of Drugs",
   legendPosition = "bottom",
-  title          ="Drug Type Distribution per Drug Group",
-  xAxisTitle     = "Quantity",
-  xAxis2Show     = TRUE,
-  xAxisShow      = FALSE,
-  smpTitle      = "Drug Group")

-

-
Finally, we look at the drug_targets_actions to observe
-their proportions as well.

-
-## get counts of the different target actions in the data
-targetActionCounts <- 
-    drug_targets_actions %>% 
+  xAxis2Show     = FALSE
+)

+

+
+

+

+
4. Analysis: Molecular Mechanisms
+

+
One of DrugBank’s most valuable features is the detailed information
+on how drugs interact with their targets (Proteins, Enzymes, etc.). Are
+drugs mostly inhibitors, agonists, or antagonists?

+
+# Prepare data: Top 10 most common Mechanisms of Action
+targetActionCounts <- drug_targets_actions %>% 
     group_by(action) %>% 
-    summarise(count = n()) %>% 
-    arrange(desc(count)) %>% 
-    top_n(10) %>% 
+    summarise(Count = n()) %>% 
+    arrange(desc(Count)) %>% 
+    slice_head(n = 10) %>% 
     column_to_rownames("action")
-#> Selecting by count
 
-## get bar chart of the 10 most occurring target actions in the data
+# Visualize
 canvasXpress(
   data            = targetActionCounts,
   graphType       = "Bar",
-  legendColumns   = 2,
-  legendPosition  = "bottom",
-  title           = "Target Actions Distribution",
+  graphOrientation = "vertical",
+  colorBy         = "Count",
+  title           = "Top 10 Mechanisms of Action",
+  xAxisTitle      = "Number of Interactions",
   showSampleNames = FALSE,
-  xAxis2Show      = TRUE,
-  xAxisShow       = FALSE)

-

-
+  legendPosition  = "none"
+)
+
+
-
- - -
- - + diff --git a/docs/articles/index.html b/docs/articles/index.html index bfa5b75..3912130 100644 --- a/docs/articles/index.html +++ b/docs/articles/index.html @@ -1,85 +1,68 @@ -Articles • dbparser - - -
-
-
-
-

Articles

+ +
+
+
+
+

Articles

All vignettes

-

+
-
DrugBank Database XML Parser
+
Unlocking DrugBank: Parsing and Visualizing Mechanistic Data
+
+
Introducing dbparser 2.2.0
+
+
Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES
-
-
+
-
+ - - diff --git a/docs/authors.html b/docs/authors.html index 3bce749..72a308f 100644 --- a/docs/authors.html +++ b/docs/authors.html @@ -1,117 +1,94 @@ -Authors and Citation • dbparser - - -
-
-
-
-
-

Authors

-
- - +
+

Authors

+
  • -

    Mohammed Ali. Author, maintainer. +

    Mohammed Ali. Author, maintainer.

  • -

    Ali Ezzat. Author. +

    Ali Ezzat. Author.

  • -

    Hao Zhu. Reviewer. +

    Hao Zhu. Reviewer.

  • -

    Emma Mendelsohn. Reviewer. +

    Emma Mendelsohn. Reviewer.

-
-
-

Citation

- Source: inst/CITATION -
-
+
+

Citation

+

Source: inst/CITATION

-

Mohammed Ali, Ali Ezzat (). - dbparser: DrugBank Database XML Parser. R package version 2.0.3.

- 
@Manual{,
+      
Mohammed Ali, Ali Ezzat ().
+                           dbparser: DrugBank Database XML Parser. R package version 2.2.0.

+      
@Manual{,
   title = {DrugBank Database XML Parser},
   author = {Mohammed Ali and Ali Ezzat},
   organization = {Interstellar for Consultinc inc.},
-  note = {R package version 2.0.3},
+  note = {R package version 2.2.0},
   url = {https://CRAN.R-project.org/package=dbparser},
 }

+
-
- -
- +
-
+ - - diff --git a/docs/index.html b/docs/index.html index c72567f..4730360 100644 --- a/docs/index.html +++ b/docs/index.html @@ -4,103 +4,85 @@ - + Drugs Databases Parser • dbparser - - - - - - - - - - - - - - - + + + + + + + + + + + + + - - - -
-
-
-
-

dbparser -

-

CRAN_Status_Badge codecov Project Status: Active – The project has reached a stable, usable state and is being actively developed. Lifecycle: stable metacran downloads CII Best Practices

+
+
+
+
+
+

dbparser +

+
+

CRAN_Status_Badge codecov Project Status: Active – The project has reached a stable, usable state and is being actively developed. Lifecycle: stable metacran downloads Rdoc Documentation CII Best Practices rOpenSci Peer-Reviewed

Overview

-

Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only two databases together such as DrugBank and KEGG.

-

Hence, dbparser package aims to parse different public drugs databases as DrugBank or KEGG into single and unified format R object called dvobject (stands for drugverse object).

+

Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only two databases together such as DrugBank, OnSIDES, and TWOSIDES.

+

Hence, dbparser package aims to parse different public drugs databases into a single and unified format R object called dvobject (stands for drugverse object).

+

With recent updates, dbparser has evolved into an integration engine, allowing you to merge mechanistic data (DrugBank) with real-world phenotypic data (OnSIDES) and drug-drug interaction risks (TWOSIDES).

That should help in:

  • working with single data object and not multiple databases in different formats,
  • using R analysis capabilities easily on drugs data,
    • -
  • ease of transferring data between researchers after performing required data analysis or dvobject and storing results in the same object in a very easy manner
    • +
  • ease of transferring data between researchers after performing required data analysis or dvobject and storing results in the same object in a very easy manner.

dvobject Structure

-

dvobject introduces a unified and compressed format of drugs data. It is an R list object that contains one or more of the following sub-lists:

+

dvobject introduces a unified and compressed format of drugs data. It is an R list object.

+

For a single database (e.g., DrugBank): It contains one or more of the following sub-lists:

  • drugs: list of data.frames that contain drugs information (i.e. synonyms, classifications, …) and it is the only mandatory list
    • @@ -113,6 +95,19 @@

    dvobject Structure @@ -120,47 +115,81 @@

    Drug Databases

    Parsers are available for the following databases (it is in progress list)

    -

    DrugBank +

    1. DrugBank

    DrugBank database is a comprehensive, freely accessible, online database containing information on drugs and drug targets. As both a bioinformatics and a cheminformatics resource, DrugBank combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. More information about DrugBank can be found here.

    In its raw form, the DrugBank database is a single XML file. Users must create an account with DrugBank and request permission to download the database. Note that this may take a couple of days.

    -

    The dbparser package parses the DrugBank XML database into R tibbles that can be explored and analyzed by the user, check this tutorial for more details.

    -

    If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the dbdataset package, which contains the DrugBank database already parsed into dvobject. Note that this is a large package that exceeds the limit set by CRAN. It is only available on GitHub.

    +

    The dbparser package parses the DrugBank XML database into R tibbles that can be explored and analyzed by the user, check this tutorial for more details.

    +

    If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the dbdataset package, which contains the DrugBank database already parsed into dvobject. Note that this is a large package that exceeds the limit set by CRAN. It is only available on GitHub.

    dbparser is tested against DrugBank versions 5.1.0 through 5.1.12 successfully. If you find errors with these versions or any other version please submit an issue here.

    +
    +

    2. OnSIDES (The Phenotype) +

    +

    OnSIDES provides adverse drug events extracted from thousands of FDA drug labels using machine learning. * Parser: parseOnSIDES() * Input: Directory containing OnSIDES CSV files.

    +
    +
    +

    3. TWOSIDES (Polypharmacy) +

    +

    TWOSIDES provides data on drug-drug interactions and the adverse events that arise when two drugs are taken together. * Parser: parseTWOSIDES() * Input: The TWOSIDES.csv.gz file.

    +
    +

+
+

Quick Start: Integration Pipeline +

+

The power of dbparser lies in its ability to chain parsers and mergers together. Here is how you can build a complete pharmacovigilance dataset:

+
+library(dbparser)
+library(dplyr)
+
+# 1. Parse the raw databases
+drugbank_db <- parseDrugBank("data/drugbank.xml")
+onsides_db  <- parseOnSIDES("data/onsides/")
+twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz")
+
+# 2. Build the Integrated Knowledge Graph
+#    DrugBank serves as the hub. We chain the merges.
+final_db <- drugbank_db %>% 
+  merge_drugbank_onsides(onsides_db) %>% 
+  merge_drugbank_twosides(twosides_db)
+
+# 3. Analyze Results
+#    Example: Accessing the enriched drug-drug interaction table
+head(final_db$integrated_data$drug_drug_interactions)
+

For a detailed case study, please refer to the Integrated Pharmacovigilance Vignette.

Installation

You can install the released version of dbparser from CRAN with:

-
+
 install.packages("dbparser")

 
or you can install the latest updates directly from the repo

-
+
 library(devtools)
 devtools::install_github("ropensci/dbparser")

 

 

 
Code of Conduct
 

-
Please note that the ‘dbparser’ project is released with a Contributor Code of Conduct. By contributing to this project, you agree to abide by its terms.

+
Please note that the ‘dbparser’ project is released with a Contributor Code of Conduct. By contributing to this project, you agree to abide by its terms.

 

 

 
Contributing Guide
 

-
👍🎉 First off, thanks for taking the time to contribute! 🎉👍 Please review our Contributing Guide.

+
👍🎉 First off, thanks for taking the time to contribute! 🎉👍 Please review our Contributing Guide.

 

 

-
Share the love ❤️
+
Share the love ❤️
 

 
Think dbparser is useful? Let others discover it, by telling them in person, via Twitter or a blog post.

 
Using dbparser for a paper you are writing? Consider citing it

-
+
 citation("dbparser")
 #> To cite dbparser in publications use:
 #> 
 #>   Mohammed Ali, Ali Ezzat ().  dbparser: DrugBank Database XML Parser.
-#>   R package version 2.0.3.
+#>   R package version 2.2.0.
 #> 
 #> A BibTeX entry for LaTeX users is
 #> 
@@ -168,15 +197,12 @@ 
Share the love ❤️#>     title = {DrugBank Database XML Parser},
 #>     author = {Mohammed Ali and Ali Ezzat},
 #>     organization = {Interstellar for Consultinc inc.},
-#>     note = {R package version 2.0.3},
+#>     note = {R package version 2.2.0},
 #>     url = {https://CRAN.R-project.org/package=dbparser},
 #>   }

 

 

-
- -
+
-
- - + diff --git a/docs/news/index.html b/docs/news/index.html index 4841929..e82ce0b 100644 --- a/docs/news/index.html +++ b/docs/news/index.html @@ -1,63 +1,104 @@ -Changelog • dbparser - +Changelog • dbparser + Skip to contents -
-
+
-
-
-

Changelog

+ 2.2.0 + + + + + + + +
+
+
+
+

Changelog

Source: NEWS.md
-

dbparser 2.0.3

+

dbparser 2.2.0

+

This is a major feature release focused on expanding dbparser’s capabilities into real-world pharmacovigilance and drug-drug interaction analysis. The integration engine has been formalized around a “Hub and Spoke” model, with DrugBank acting as the central hub.

+
+

NEW FEATURES

+
  • +New Parser: parseOnSIDES() +
    • Parses the relational CSV files from the OnSIDES database, a modern resource for adverse drug events extracted from FDA labels.
      • +
    • Returns a dvobject containing the 7 core relational tables and an optional high_confidence summary table.
      • +
    • +
  • +New Parser: parseTWOSIDES() +
    • Parses the TWOSIDES database, the leading resource for drug-drug interaction (DDI) adverse event signals from real-world data.
      • +
    • Returns a dvobject containing the drug_drug_interactions table.
      • +
    • The parser correctly handles known column name misspellings in the source data (e.g., drug_1_rxnorn_id).
      • +
    • +
  • +New Integration Function: merge_drugbank_onsides() +
    • Merges a DrugBank dvobject with an OnSIDES dvobject.
      • +
    • Automatically creates an enriched integrated_data list, linking OnSIDES data to DrugBank IDs via RxNorm CUIs.
      • +
    • The function is chainable, meaning it can be used in a %>% pipeline after other merge functions.
      • +
    • +
  • +New Integration Function: merge_drugbank_twosides() +
    • Merges a DrugBank dvobject with a TWOSIDES dvobject.
      • +
    • Performs a “double join” to enrich both drugs in an interaction pair with their DrugBank IDs and names.
      • +
    • Uses a robust “union” logic to keep interactions even if only one of the two drugs is present in the input DrugBank object.
      • +
    • The function is also chainable.
      • +
    • +
  • +Subset a DrugBank dvobject function: subset_drugbank_dvobject() +
    • Intelligently filters a DrugBank dvobject to retain only the data associated with a specified list of drugbank_ids. It correctly handles the deep, multi-level nested structure of the entire object, including the complex relationships within the cett list.
      • +
    • +
  • +Subset an OnSIDES dvobject function: subset_onsides_dvobject() +
    • Intelligently filters an OnSIDES dvobject by cascading filters through the relational tables, ensuring the final subset is self-consistent.
      • +
    • +
  • Adding metadata to existing dvobject objects using function: add_database_info()
    • +
  • +Major enhancements to function show_dvobject_metadata() +
    • Displays information about passed dbobject object including basic info, database metadata, and all data.frames contained within nested lists.
      • +
    • +
  • Run vignette("dbparser_2_2", package = "dbparser") for more info
    • +
+
+

DOCUMENTATION

+
  • +New Vignette: “Integrated Pharmacovigilance” +
    • A comprehensive new tutorial demonstrating a full, three-way integration of DrugBank, OnSIDES, and TWOSIDES.
      • +
    • Includes a complete scientific case study analyzing single-drug vs. polypharmacy risks.
      • +
    • Introduces a reproducible example workflow using a pre-computed RDS data object hosted externally to keep the package lightweight.
      • +
    • Run vignette("drugbank_nside", package = "dbparser") for more info
      • +
    • +
  • Updated existing vignette and package Readme with enhanced examples
    • +
+
+

BUG FIXES & MINOR IMPROVEMENTS

+
  • Several minor fixes are done
    • +
+
+
+

dbparser 2.0.3

CRAN release: 2024-04-20

Enhancements

  • Updated unit tests with latest DrugBank DB info v 5.1.12
    • @@ -68,7 +109,7 @@

    Bugs Fixes -

    dbparser 2.0.22024-02-16

    +

    dbparser 2.0.2

    CRAN release: 2024-02-16

    Enhancements

    • Replaced “-” with “_” in tibbles column names (#111)
      • @@ -78,7 +119,7 @@

      Enhancements

-

dbparser 2.0.12023-03-27

+

dbparser 2.0.1

CRAN release: 2023-03-27

Bugs Fixes

  • Fixed output references (#147)
    • @@ -88,7 +129,7 @@

    Bugs Fixes -

    dbparser 2.0.02023-03-17

    +

    dbparser 2.0.0

    CRAN release: 2023-03-17

    Breaking changes

    • Deprecated saving parsed data into given database (#140)
      • @@ -111,7 +152,7 @@

      Minor Fixes

-

dbparser 1.2.02020-08-26

+

dbparser 1.2.0

CRAN release: 2020-08-26

UI Changes

  • Introduce progress bar in parser functions
    • @@ -153,7 +194,7 @@

    Minor Fixes

-

dbparser 1.1.22020-06-08

+

dbparser 1.1.2

CRAN release: 2020-06-08

Major Changes

  • Enhance many memory and performance issues for many parsers.
    • @@ -163,14 +204,14 @@

    Major Changes

-

dbparser 1.1.12020-05-10

+

dbparser 1.1.1

CRAN release: 2020-05-10

  • Fix column size issue while importing into SQL Server (#91)
  • Fix dbparser and upcoming CRAN release of dplyr issues (#92)
  • Fix CRAN Notes (#93)
  • Fix package documentation and site references
-

dbparser 1.1.02020-02-21

+

dbparser 1.1.0

CRAN release: 2020-02-21

Major Changes

  • Functions have been splitted into 6 categories DrugBank Database Loading, Carriers, Targets, Transporters, Drug and common parsers. All function names are changed to reflect the function family. The related documentation is also updated (#66, #75).
    • @@ -193,25 +234,25 @@

    DOCUMENTATION FIXES

-

dbparser 1.0.42019-08-28

+

dbparser 1.0.4

CRAN release: 2019-08-28

  • Fix save drugs tibbles as csv several issues.
  • Update SQL database tibbles saver functions.
  • Update SQL database saver functions documentations.
  • Support MariaDB and introduce related functionalities.
-

dbparser 1.0.32019-07-11

+

dbparser 1.0.3

CRAN release: 2019-07-11

  • Fix CRAN errors and notes
-

dbparser 1.0.22019-07-08

+

dbparser 1.0.2

CRAN release: 2019-07-08

  • Fix zip file location issue
  • Replace Secondary and third keys columns from drug framework with other_keys column that contains any other keys that might exist in addition to the primary key
  • Add average-mass, monoisotopic-mass and calculated-properties parsers.
  • Support saving parsed drugs related parsed database as csv
-

dbparser 1.0.12019-04-16

+

dbparser 1.0.1

CRAN release: 2019-04-16

  • Fix CRAN Note
  • Improve documentation
  • Refactor unused functions
    • @@ -225,32 +266,26 @@

    dbparser 1.0.1Support reading zip file containing DrugBank xml database

-

dbparser 1.0.02018-12-17

+

dbparser 1.0.0

CRAN release: 2018-12-17

  • Initial release that contains core functionalities
-
+
- +
-
- - diff --git a/docs/pkgdown.js b/docs/pkgdown.js index 6f0eee4..0a5573a 100644 --- a/docs/pkgdown.js +++ b/docs/pkgdown.js @@ -1,108 +1,162 @@ /* http://gregfranko.com/blog/jquery-best-practices/ */ -(function($) { - $(function() { +(function ($) { + $(function () { - $('.navbar-fixed-top').headroom(); + $('nav.navbar').headroom(); - $('body').css('padding-top', $('.navbar').height() + 10); - $(window).resize(function(){ - $('body').css('padding-top', $('.navbar').height() + 10); + Toc.init({ + $nav: $("#toc"), + $scope: $("main h2, main h3, main h4, main h5, main h6") }); - $('[data-toggle="tooltip"]').tooltip(); - - var cur_path = paths(location.pathname); - var links = $("#navbar ul li a"); - var max_length = -1; - var pos = -1; - for (var i = 0; i < links.length; i++) { - if (links[i].getAttribute("href") === "#") - continue; - // Ignore external links - if (links[i].host !== location.host) - continue; - - var nav_path = paths(links[i].pathname); - - var length = prefix_length(nav_path, cur_path); - if (length > max_length) { - max_length = length; - pos = i; - } + if ($('#toc').length) { + $('body').scrollspy({ + target: '#toc', + offset: $("nav.navbar").outerHeight() + 1 + }); } - // Add class to parent
  • , and enclosing
  • if in dropdown - if (pos >= 0) { - var menu_anchor = $(links[pos]); - menu_anchor.parent().addClass("active"); - menu_anchor.closest("li.dropdown").addClass("active"); - } - }); - - function paths(pathname) { - var pieces = pathname.split("/"); - pieces.shift(); // always starts with / + // Activate popovers + $('[data-bs-toggle="popover"]').popover({ + container: 'body', + html: true, + trigger: 'focus', + placement: "top", + sanitize: false, + }); - var end = pieces[pieces.length - 1]; - if (end === "index.html" || end === "") - pieces.pop(); - return(pieces); - } + $('[data-bs-toggle="tooltip"]').tooltip(); - // Returns -1 if not found - function prefix_length(needle, haystack) { - if (needle.length > haystack.length) - return(-1); + /* Clipboard --------------------------*/ - // Special case for length-0 haystack, since for loop won't run - if (haystack.length === 0) { - return(needle.length === 0 ? 0 : -1); + function changeTooltipMessage(element, msg) { + var tooltipOriginalTitle = element.getAttribute('data-bs-original-title'); + element.setAttribute('data-bs-original-title', msg); + $(element).tooltip('show'); + element.setAttribute('data-bs-original-title', tooltipOriginalTitle); } - for (var i = 0; i < haystack.length; i++) { - if (needle[i] != haystack[i]) - return(i); - } + if (ClipboardJS.isSupported()) { + $(document).ready(function () { + var copyButton = ""; - return(haystack.length); - } + $("div.sourceCode").addClass("hasCopyButton"); - /* Clipboard --------------------------*/ + // Insert copy buttons: + $(copyButton).prependTo(".hasCopyButton"); - function changeTooltipMessage(element, msg) { - var tooltipOriginalTitle=element.getAttribute('data-original-title'); - element.setAttribute('data-original-title', msg); - $(element).tooltip('show'); - element.setAttribute('data-original-title', tooltipOriginalTitle); - } + // Initialize tooltips: + $('.btn-copy-ex').tooltip({ container: 'body' }); - if(ClipboardJS.isSupported()) { - $(document).ready(function() { - var copyButton = ""; + // Initialize clipboard: + var clipboard = new ClipboardJS('[data-clipboard-copy]', { + text: function (trigger) { + return trigger.parentNode.textContent.replace(/\n#>[^\n]*/g, ""); + } + }); - $("div.sourceCode").addClass("hasCopyButton"); + clipboard.on('success', function (e) { + changeTooltipMessage(e.trigger, 'Copied!'); + e.clearSelection(); + }); - // Insert copy buttons: - $(copyButton).prependTo(".hasCopyButton"); + clipboard.on('error', function (e) { + changeTooltipMessage(e.trigger, 'Press Ctrl+C or Command+C to copy'); + }); - // Initialize tooltips: - $('.btn-copy-ex').tooltip({container: 'body'}); + }); + } - // Initialize clipboard: - var clipboardBtnCopies = new ClipboardJS('[data-clipboard-copy]', { - text: function(trigger) { - return trigger.parentNode.textContent.replace(/\n#>[^\n]*/g, ""); + /* Search marking --------------------------*/ + var url = new URL(window.location.href); + var toMark = url.searchParams.get("q"); + var mark = new Mark("main#main"); + if (toMark) { + mark.mark(toMark, { + accuracy: { + value: "complementary", + limiters: [",", ".", ":", "/"], } }); + } - clipboardBtnCopies.on('success', function(e) { - changeTooltipMessage(e.trigger, 'Copied!'); - e.clearSelection(); - }); + /* Search --------------------------*/ + /* Adapted from https://github.com/rstudio/bookdown/blob/2d692ba4b61f1e466c92e78fd712b0ab08c11d31/inst/resources/bs4_book/bs4_book.js#L25 */ + // Initialise search index on focus + var fuse; + $("#search-input").focus(async function (e) { + if (fuse) { + return; + } - clipboardBtnCopies.on('error', function() { - changeTooltipMessage(e.trigger,'Press Ctrl+C or Command+C to copy'); - }); + $(e.target).addClass("loading"); + var response = await fetch($("#search-input").data("search-index")); + var data = await response.json(); + + var options = { + keys: ["what", "text", "code"], + ignoreLocation: true, + threshold: 0.1, + includeMatches: true, + includeScore: true, + }; + fuse = new Fuse(data, options); + + $(e.target).removeClass("loading"); }); - } + + // Use algolia autocomplete + var options = { + autoselect: true, + debug: true, + hint: false, + minLength: 2, + }; + var q; + async function searchFuse(query, callback) { + await fuse; + + var items; + if (!fuse) { + items = []; + } else { + q = query; + var results = fuse.search(query, { limit: 20 }); + items = results + .filter((x) => x.score <= 0.75) + .map((x) => x.item); + if (items.length === 0) { + items = [{ dir: "Sorry 😿", previous_headings: "", title: "No results found.", what: "No results found.", path: window.location.href }]; + } + } + callback(items); + } + $("#search-input").autocomplete(options, [ + { + name: "content", + source: searchFuse, + templates: { + suggestion: (s) => { + if (s.title == s.what) { + return `${s.dir} >
    ${s.title}
    `; + } else if (s.previous_headings == "") { + return `${s.dir} >
    ${s.title}
    > ${s.what}`; + } else { + return `${s.dir} >
    ${s.title}
    > ${s.previous_headings} > ${s.what}`; + } + }, + }, + }, + ]).on('autocomplete:selected', function (event, s) { + window.location.href = s.path + "?q=" + q + "#" + s.id; + }); + }); })(window.jQuery || window.$) + +document.addEventListener('keydown', function (event) { + // Check if the pressed key is '/' + if (event.key === '/') { + event.preventDefault(); // Prevent any default action associated with the '/' key + document.getElementById('search-input').focus(); // Set focus to the search input + } +}); diff --git a/docs/pkgdown.yml b/docs/pkgdown.yml index 51a0103..da7bd73 100644 --- a/docs/pkgdown.yml +++ b/docs/pkgdown.yml @@ -1,7 +1,11 @@ -pandoc: 3.1.1 -pkgdown: 2.0.7 +pandoc: 3.6.3 +pkgdown: 2.2.0 pkgdown_sha: ~ articles: dbparser: dbparser.html -last_built: 2024-04-20T04:20Z - + dbparser_2_2: dbparser_2_2.html + drugbank_nside: drugbank_nside.html +last_built: 2025-12-27T13:08Z +urls: + reference: https://docs.ropensci.org/dbparser/reference + article: https://docs.ropensci.org/dbparser/articles diff --git a/docs/reference/articles.html b/docs/reference/articles.html index 9b60450..17f5e18 100644 --- a/docs/reference/articles.html +++ b/docs/reference/articles.html @@ -1,67 +1,49 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser

    + Source: R/references_parsers.R +
    articles.Rd
    -
    +

    Return a list of articles that were used as references for drugs carriers

    -
    +
    +

    Usage

    drugs_articles()
 
 carriers_articles()
@@ -73,11 +55,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser
    
 transporters_articles()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Identifier for the article being referenced. This is unique across all reference types (books, links, article, attachments).

    @@ -94,27 +74,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/attachments.html b/docs/reference/attachments.html index cd90f3b..8aa0b69 100644 --- a/docs/reference/attachments.html +++ b/docs/reference/attachments.html @@ -1,67 +1,49 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser

    + Source: R/references_parsers.R +
    attachments.Rd
    -
    +

    Return a list of attachment that were used as references for drugs carriers

    -
    +
    +

    Usage

    drugs_attachments()
 
 carriers_attachments()
@@ -73,11 +55,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parsertransporters_attachments()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Identifier for the article being referenced. This is unique across all reference types (books, links, article, attachments).

    @@ -94,27 +74,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/books.html b/docs/reference/books.html index 8a34acf..61d3179 100644 --- a/docs/reference/books.html +++ b/docs/reference/books.html @@ -1,69 +1,52 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser

    + Source: R/references_parsers.R +
    books.Rd
    -
    +

    Return a list of text books that were used as references for drugs, carriers, enzymes, targets or transporters

    -
    +
    +

    Usage

    drugs_textbooks()
 
 carriers_textbooks()
@@ -75,11 +58,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser
    
 transporters_textbooks()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Identifier for the article being referenced. This is unique across all reference types (books, links, article, attachments).

    @@ -96,27 +77,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/carriers.html b/docs/reference/carriers.html index e89de0b..c4ba25d 100644 --- a/docs/reference/carriers.html +++ b/docs/reference/carriers.html @@ -1,263 +1,8 @@ - - - + - - - - -Extracts the drug carriers element and return data as tibble. — carriers • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers returns tibble of drug carriers elements.

    -
    - - 
    carriers(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers element of drug node in - DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers()
-
-# will throw an error, as database_connection is NULL
-carriers(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_actions.html b/docs/reference/carriers_actions.html index 9fd50fb..49c4d12 100644 --- a/docs/reference/carriers_actions.html +++ b/docs/reference/carriers_actions.html @@ -1,270 +1,8 @@ - - - + - - - - -Extracts the drug carriers actions element and return data as tibble. — carriers_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers actions element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_actions returns tibble of drug - carriers actions elements.

    -
    - - 
    carriers_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers actions node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers actions element of drug - node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_actions()
-
-# will throw an error, as database_connection is NULL
-carriers_actions(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_actions(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_actions(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist override it and return it.
-
-carriers_actions(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_articles.html b/docs/reference/carriers_articles.html index e717a02..b95e027 100644 --- a/docs/reference/carriers_articles.html +++ b/docs/reference/carriers_articles.html @@ -1,271 +1,8 @@ - - - + - - - - -Extracts the drug carriers articles element and return - data as tibble. — carriers_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers articles element and return - data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_articles returns tibble of -drug carriers articles elements.

    -
    - - 
    carriers_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers_articles node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers articles element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_articles()
-
-# will throw an error, as database_connection is NULL
-carriers_articles(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_articles(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-# current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_articles(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_links.html b/docs/reference/carriers_links.html index 575def3..b768dff 100644 --- a/docs/reference/carriers_links.html +++ b/docs/reference/carriers_links.html @@ -1,264 +1,8 @@ - - - + - - - - -Extracts the drug carriers links element and return data as tibble. — carriers_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers links element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    drug_groups returns tibble of drug carriers links elements.

    -
    - - 
    carriers_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers_links node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers links element of drug node in -DrugBank xml database with the option to save it in a predefined -database via passed database connection. -It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_links()
-
-# will throw an error, as database_connection is NULL
-carriers_links(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_links(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_links(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist override it and return it.
-carriers_links(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_polypeptides_go.html b/docs/reference/carriers_polypeptides_go.html index d941d06..bda310f 100644 --- a/docs/reference/carriers_polypeptides_go.html +++ b/docs/reference/carriers_polypeptides_go.html @@ -1,278 +1,8 @@ - - - + - - - - -Extracts the drug carriers polypeptides go classifiers - element and return data as tibble. — carriers_polypeptides_go • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers polypeptides go classifiers - element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_polypeptides_go returns -tibble of drug carriers polypeptides go classifiers elements.

    -
    - - 
    carriers_polypeptides_go(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers polypeptides go classifiers node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers polypeptides go -classifiers element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_polypeptides_go()
-
-# will throw an error, as database_connection is NULL
-carriers_polypeptides_go(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_polypeptides_go(save_table = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_go(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_go(
-  save_table = TRUE,
-  save_csv = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_go(
-  save_csv = TRUE,
-  csv_path = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_polypeptides_go(
-  save_csv = TRUE,
-  csv_path = TRUE, override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_polypeptides_pfams.html b/docs/reference/carriers_polypeptides_pfams.html index 12c564d..cac389d 100644 --- a/docs/reference/carriers_polypeptides_pfams.html +++ b/docs/reference/carriers_polypeptides_pfams.html @@ -1,272 +1,8 @@ - - - + - - - - -Extracts the drug carriers polypeptides pfams element and return data as -tibble. — carriers_polypeptides_pfams • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers polypeptides pfams element and return data as -tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_polypeptides_pfams returns tibble - of drug carriers polypeptides pfams elements.

    -
    - - 
    carriers_polypeptides_pfams(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers polypeptides pfams node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers polypeptides pfams element of - drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_polypeptides_pfams()
-
-# will throw an error, as database_connection is NULL
-carriers_polypeptides_pfams(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_polypeptides_pfams(save_table = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_pfams(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-#  current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_pfams(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_pfams(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_polypeptides_pfams(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_polypeptides_syn.html b/docs/reference/carriers_polypeptides_syn.html index cedc443..c0f768c 100644 --- a/docs/reference/carriers_polypeptides_syn.html +++ b/docs/reference/carriers_polypeptides_syn.html @@ -1,274 +1,8 @@ - - - + - - - - -Extracts the drug carriers polypeptides syn element and return data as -tibble. — carriers_polypeptides_syn • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers polypeptides syn element and return data as -tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_polypeptides_syn returns - tibble of drug carriers polypeptides syn elements.

    -
    - - 
    carriers_polypeptides_syn(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers polypeptides syn node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers polypeptides syn - element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_polypeptides_syn()
-
-# will throw an error, as database_connection is NULL
-carriers_polypeptides_syn(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_polypeptides_syn(save_table = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_syn(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_syn(
-  save_table = TRUE,
-  save_csv = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_syn(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_polypeptides_syn(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_textbooks.html b/docs/reference/carriers_textbooks.html index bf0c5eb..088dfba 100644 --- a/docs/reference/carriers_textbooks.html +++ b/docs/reference/carriers_textbooks.html @@ -1,268 +1,8 @@ - - - + - - - - -Extracts the drug carriers textbooks element and return data as tibble. — carriers_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers textbooks element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_textbooks returns tibble of drug carriers - textbooks elements.

    -
    - - 
    carriers_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers textbooks element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_textbooks()
-
-# will throw an error, as database_connection is NULL
-carriers_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-# current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_textbooks(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist override it and return it.
-carriers_textbooks(
-  save_csv = TRUE, csv_path = TRUE, override =
-    TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/cett_actions_doc.html b/docs/reference/cett_actions_doc.html index fd3a5fb..ed18bf8 100644 --- a/docs/reference/cett_actions_doc.html +++ b/docs/reference/cett_actions_doc.html @@ -1,67 +1,49 @@ -Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Actions parsers

    - Source: R/cett_actions_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Actions parsers

    + Source: R/cett_actions_parsers.R +
    cett_actions_doc.Rd
    -
    +

    Collection of related actions

    -
    +
    +

    Usage

    carriers_actions()
 
 enzymes_actions()
@@ -71,11 +53,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Actions parsers
    
 transporters_actions()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    action
    +
    +

    Value

    +

    a tibble with 2 variables:

    action

    describe related action

    parent_id
    @@ -84,27 +64,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_doc.html b/docs/reference/cett_doc.html index a8565b7..6081640 100644 --- a/docs/reference/cett_doc.html +++ b/docs/reference/cett_doc.html @@ -1,71 +1,55 @@ -Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc • dbparserCarriers/ Enzymes/ Targets/ Transporters parsers — cett_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters parsers

    - Source: R/cett_general_information_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters parsers

    + Source: R/cett_general_information_parsers.R +
    cett_doc.Rd
    -
    +

    Protein targets of drug action, enzymes that are inhibited/induced or involved in metabolism, and carrier or transporter proteins involved in movement of the drug across biological membranes.

    -
    +
    +

    Usage

    carriers()
 
 enzymes()
@@ -75,11 +59,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters parsers
    
 transporters()
    -
    -

    Value

    - - -

    a tibble with 6 variables (8 for enzymes):

    id
    +
    +

    Value

    +

    a tibble with 6 variables (8 for enzymes):

    id

    Universal Protein Resource (UniProt) Identifier for the record

    name
    @@ -109,27 +91,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_ex_identity_doc.html b/docs/reference/cett_ex_identity_doc.html index f8f67e1..5a65842 100644 --- a/docs/reference/cett_ex_identity_doc.html +++ b/docs/reference/cett_ex_identity_doc.html @@ -1,72 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers -parsers — cett_ex_identity_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers -parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_ex_identity_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide external identifiers for targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypep_ex_ident()
 
 enzymes_polypep_ex_ident()
@@ -76,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers
 transporters_polypep_ex_ident()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    resource
    +
    +

    Value

    +

    a tibble with 3 variables:

    resource

    Name of the source database.

    identifier
    @@ -92,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_go_doc.html b/docs/reference/cett_go_doc.html index c5a1cc8..960d7ce 100644 --- a/docs/reference/cett_go_doc.html +++ b/docs/reference/cett_go_doc.html @@ -1,72 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier -parsers — cett_go_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier -parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_go_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide go classifier for targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides_go()
 
 enzymes_polypeptides_go()
@@ -76,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier
 transporters_polypeptides_go()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    category
    +
    +

    Value

    +

    a tibble with 3 variables:

    category
    description
    @@ -92,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_nodes_options.html b/docs/reference/cett_nodes_options.html index 2787994..e3c34cf 100644 --- a/docs/reference/cett_nodes_options.html +++ b/docs/reference/cett_nodes_options.html @@ -1,105 +1,83 @@ -returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options • dbparser - - -
    -
    -
    -
    -

    returns carriers, enzymes,targets and transporters node valid options.

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    returns carriers, enzymes,targets and transporters node valid options.

    + Source: R/drugbank_parser.R +
    cett_nodes_options.Rd
    -
    +

    returns carriers, enzymes,targets and transporters node valid options.

    -
    +
    +

    Usage

    cett_nodes_options()
    -
    -

    Value

    - - -

    list of CETT valid options

    +
    +

    Value

    +

    list of CETT valid options

    - - -
    +
    -
    + - - diff --git a/docs/reference/cett_poly_doc.html b/docs/reference/cett_poly_doc.html index 49c3bd3..ea4e4dd 100644 --- a/docs/reference/cett_poly_doc.html +++ b/docs/reference/cett_poly_doc.html @@ -1,69 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers

    - Source: R/cett_polypeptide_general_infromation_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers

    + Source: R/cett_polypeptide_general_infromation_parsers.R +
    cett_poly_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides()
 
 enzymes_polypeptides()
@@ -73,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers
    
 transporters_polypeptides()
    -
    -

    Value

    - - -

    a tibble with 20 variables:

    id
    +
    +

    Value

    +

    a tibble with 20 variables:

    id

    Universal Protein Resource (UniProt) identifier

    @@ -151,27 +132,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_poly_pfms_doc.html b/docs/reference/cett_poly_pfms_doc.html index 2fbce9d..c0259b7 100644 --- a/docs/reference/cett_poly_pfms_doc.html +++ b/docs/reference/cett_poly_pfms_doc.html @@ -1,69 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_poly_pfms_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide PFAMS targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides_pfams()
 
 enzymes_polypeptides_pfams()
@@ -73,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers
    
 transporters_polypeptides_pfams()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    name
    +
    +

    Value

    +

    a tibble with 3 variables:

    name

    The sequence of the associated gene.

    identifier
    @@ -89,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_poly_syn_doc.html b/docs/reference/cett_poly_syn_doc.html index 66004de..716d511 100644 --- a/docs/reference/cett_poly_syn_doc.html +++ b/docs/reference/cett_poly_syn_doc.html @@ -1,69 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_poly_syn_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide synonyms for targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides_syn()
 
 enzymes_polypeptides_syn()
@@ -73,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers
    
 transporters_polypeptides_syn()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    synonym
    +
    +

    Value

    +

    a tibble with 2 variables:

    synonym
    parent_key
    @@ -86,27 +67,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/dbparser.html b/docs/reference/dbparser.html index 1bb573c..85f97c2 100644 --- a/docs/reference/dbparser.html +++ b/docs/reference/dbparser.html @@ -1,134 +1,113 @@ -dbparser: A package for reading and parsing DrugBank xml database. — dbparser • dbparserdbparser: A package for reading and parsing DrugBank xml database. — dbparser • dbparser - - -
    -
    -
    -
    -

    dbparser: A package for reading and parsing DrugBank xml database.

    - Source: R/dbparser-package.R - + + + +
    +
    +
    +
    +

    dbparser: A package for reading and parsing DrugBank xml database.

    + Source: R/dbparser-package.R +
    dbparser.Rd
    -
    +

    The main purpose of the `dbparser` package is to parse [DrugBank](https://go.drugbank.com/) database which is downloadable in XML format from [this link](https://go.drugbank.com/releases/latest).

    -
    -

    Details

    +
    +

    Details

    The parsed data can then be explored and analyzed.

    -

    To achieve this purpose, `dbparser`` package provides three main categories +

    To achieve this purpose, `dbparser“ package provides three main categories of functions:

    - xml db reader,

    - DrugBank elements parsers,

    For more information kindly check the reference/index (https://docs.ropensci.org/dbparser/reference/index.html)

    -
    -

    xml db reader functions

    - +
    +

    xml db reader functions

    +

    Reads DrugBank xml database and build drug elements full tree in memory

    -
    -

    parsers functions

    - +
    +

    parsers functions

    +

    Each parser function is responsible of parsing certain drug element and returning its tibble.

    Check this tutorial (https://docs.ropensci.org/dbparser/articles/dbparser.html)

    -
    -

    See also

    -

    Useful links:

    +
    -
    + - - diff --git a/docs/reference/drug_affected_organisms.html b/docs/reference/drug_affected_organisms.html index da549fb..b09bc53 100644 --- a/docs/reference/drug_affected_organisms.html +++ b/docs/reference/drug_affected_organisms.html @@ -1,77 +1,58 @@ -Drug Affected Organism parser — drug_affected_organisms • dbparser - - -
    -
    -
    -
    -

    Drug Affected Organism parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Affected Organism parser

    + Source: R/drug_parsers.R +
    drug_affected_organisms.Rd
    -
    +

    Organisms in which the drug may display activity; activity may depend on local susceptibility patterns and resistance.

    -
    +
    +

    Usage

    drug_affected_organisms()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    affected-organism
    +
    +

    Value

    +

    a tibble with 2 variables:

    affected-organism

    affected-organism name

    drugbank_id
    @@ -80,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_ahfs_codes.html b/docs/reference/drug_ahfs_codes.html index 347ebef..bb041c4 100644 --- a/docs/reference/drug_ahfs_codes.html +++ b/docs/reference/drug_ahfs_codes.html @@ -1,75 +1,55 @@ -Drug ahfs-codes parser — drug_ahfs_codes • dbparser - - -
    -
    -
    -
    -

    Drug ahfs-codes parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug ahfs-codes parser

    + Source: R/drug_parsers.R +
    drug_ahfs_codes.Rd
    -
    +

    The American Hospital Formulary Service (AHFS) identifier for this drug.

    -
    +
    +

    Usage

    drug_ahfs_codes()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    ahfs-code
    +
    +

    Value

    +

    a tibble with the following variables:

    ahfs-code
    drugbank_id
    @@ -78,27 +58,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_atc_codes.html b/docs/reference/drug_atc_codes.html index 05e91c8..ed86376 100644 --- a/docs/reference/drug_atc_codes.html +++ b/docs/reference/drug_atc_codes.html @@ -1,106 +1,83 @@ -Drug ATC Codes element parser — drug_atc_codes • dbparser - - -
    -
    -
    -
    -

    Drug ATC Codes element parser

    - Source: R/drug_atc_codes_node_parser.R - + + + +
    +
    +
    +
    +

    Drug ATC Codes element parser

    + Source: R/drug_atc_codes_node_parser.R +
    drug_atc_codes.Rd
    -
    +

    The Anatomical Therapeutic Classification (ATC) code for the drug assigned by the World Health Organization Anatomical Chemical Classification System.

    -
    +
    +

    Usage

    drug_atc_codes()
    -
    -

    Value

    - - -

    a tibble with 10 variables

    +
    +

    Value

    +

    a tibble with 10 variables

    -
    -

    Details

    -

    Each `atc-code`` row has one or more level. The atc-code and level> +

    +

    Details

    +

    Each `atc-code“ row has one or more level. The atc-code and level> have a code the code assigned by the World Health Organization Anatomical Therapeutic Chemical Classification system.

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_calc_prop.html b/docs/reference/drug_calc_prop.html index 1e7bbbb..5ac1018 100644 --- a/docs/reference/drug_calc_prop.html +++ b/docs/reference/drug_calc_prop.html @@ -1,79 +1,61 @@ -Drug Calculated Properties parser — drug_calc_prop • dbparserDrug Calculated Properties parser — drug_calc_prop • dbparser - - -
    -
    -
    -
    -

    Drug Calculated Properties parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Calculated Properties parser

    + Source: R/drug_parsers.R +
    drug_calc_prop.Rd
    -
    +

    Drug properties that have been predicted by ChemAxon or ALOGPS based on the imputed chemical structure. Associated links below will redirect to descriptions of the specific term.

    -
    +
    +

    Usage

    drug_calc_prop()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    kind
    +
    +

    Value

    +

    a tibble with 4 variables:

    kind

    Name of the property.

    value
    @@ -90,27 +72,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_categories.html b/docs/reference/drug_categories.html index 35ae29e..29d836b 100644 --- a/docs/reference/drug_categories.html +++ b/docs/reference/drug_categories.html @@ -1,75 +1,55 @@ -Drug Categories parser — drug_categories • dbparser - - -
    -
    -
    -
    -

    Drug Categories parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Categories parser

    + Source: R/drug_parsers.R +
    drug_categories.Rd
    -
    +

    General categorizations of the drug.

    -
    +
    +

    Usage

    drug_categories()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    category
    +
    +

    Value

    +

    a tibble with 2 variables:

    category

    category name

    mesh-id
    @@ -82,27 +62,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_classification.html b/docs/reference/drug_classification.html index fb47ce9..6952c9b 100644 --- a/docs/reference/drug_classification.html +++ b/docs/reference/drug_classification.html @@ -1,77 +1,58 @@ -Drug Classification parser — drug_classification • dbparser - - -
    -
    -
    -
    -

    Drug Classification parser

    - Source: R/drug_classfication_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Classification parser

    + Source: R/drug_classfication_node_parser.R +
    drug_classification.Rd
    -
    +

    A description of the hierarchical chemical classification of the drug; imported from ClassyFire.

    -
    +
    +

    Usage

    drug_classification()
    -
    -

    Value

    - - -

    a tibble with 9 variables:

    description
    +
    +

    Value

    +

    a tibble with 9 variables:

    description
    direct-parent
    @@ -101,27 +82,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_dosages.html b/docs/reference/drug_dosages.html index b9bdc34..66bc921 100644 --- a/docs/reference/drug_dosages.html +++ b/docs/reference/drug_dosages.html @@ -1,75 +1,55 @@ -Drug Dosages parser — drug_dosages • dbparser - - -
    -
    -
    -
    -

    Drug Dosages parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Dosages parser

    + Source: R/drug_parsers.R +
    drug_dosages.Rd
    -
    +

    A list of the commercially available dosages of the drug.

    -
    +
    +

    Usage

    drug_dosages()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    form
    +
    +

    Value

    +

    a tibble with the following variables:

    form

    The pharmaceutical formulation by which the drug is introduced into the body

    @@ -85,27 +65,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_ex_identity.html b/docs/reference/drug_ex_identity.html index cc0fc41..7b307e6 100644 --- a/docs/reference/drug_ex_identity.html +++ b/docs/reference/drug_ex_identity.html @@ -1,77 +1,58 @@ -Drug External Identifiers parser — drug_ex_identity • dbparser - - -
    -
    -
    -
    -

    Drug External Identifiers parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug External Identifiers parser

    + Source: R/drug_parsers.R +
    drug_ex_identity.Rd
    -
    +

    Identifiers used in other websites or databases providing information about this drug.

    -
    +
    +

    Usage

    drug_ex_identity()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    resource
    +
    +

    Value

    +

    a tibble with the following variables:

    resource

    Name of the source database.

    identifier
    @@ -83,27 +64,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_exp_prop.html b/docs/reference/drug_exp_prop.html index 210209e..79edc6d 100644 --- a/docs/reference/drug_exp_prop.html +++ b/docs/reference/drug_exp_prop.html @@ -1,75 +1,55 @@ -Drug Experimental Properties parser — drug_exp_prop • dbparser - - -
    -
    -
    -
    -

    Drug Experimental Properties parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Experimental Properties parser

    + Source: R/drug_parsers.R +
    drug_exp_prop.Rd
    -
    +

    Drug properties that have been experimentally proven

    -
    +
    +

    Usage

    drug_exp_prop()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    kind
    +
    +

    Value

    +

    a tibble with the following variables:

    kind

    Name of the property.

    value
    @@ -135,27 +115,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_external_links.html b/docs/reference/drug_external_links.html index d6710ad..0ec2952 100644 --- a/docs/reference/drug_external_links.html +++ b/docs/reference/drug_external_links.html @@ -1,75 +1,55 @@ -Drug External Links parser — drug_external_links • dbparser - - -
    -
    -
    -
    -

    Drug External Links parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug External Links parser

    + Source: R/drug_parsers.R +
    drug_external_links.Rd
    -
    +

    Links to other websites or databases providing information about this drug.

    -
    +
    +

    Usage

    drug_external_links()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    resource
    +
    +

    Value

    +

    a tibble with the following variables:

    resource

    Name of the source website.

    identifier
    @@ -81,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_food_interactions.html b/docs/reference/drug_food_interactions.html index 10f4f86..5ab5c6e 100644 --- a/docs/reference/drug_food_interactions.html +++ b/docs/reference/drug_food_interactions.html @@ -1,75 +1,55 @@ -Drug Groups parser — drug_food_interactions • dbparser - - -
    -
    -
    -
    -

    Drug Groups parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Groups parser

    + Source: R/drug_parsers.R +
    drug_food_interactions.Rd
    -
    +

    Food that may interact with this drug.

    -
    +
    +

    Usage

    drug_food_interactions()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    food-interaction
    +
    +

    Value

    +

    a tibble with the following variables:

    food-interaction
    drugbank_id
    @@ -78,27 +58,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_general_information.html b/docs/reference/drug_general_information.html index 1ed412a..13f40d7 100644 --- a/docs/reference/drug_general_information.html +++ b/docs/reference/drug_general_information.html @@ -1,77 +1,58 @@ -Drugs General Information parser — drug_general_information • dbparser - - -
    -
    -
    -
    -

    Drugs General Information parser

    - Source: R/drug_main_node_parser.R - + + + +
    +
    +
    +
    +

    Drugs General Information parser

    + Source: R/drug_main_node_parser.R +
    drug_general_information.Rd
    -
    +

    A description of the hierarchical chemical classification of the drug; imported from ClassyFire.

    -
    +
    +

    Usage

    drug_general_information()
    -
    -

    Value

    - - -

    a tibble with 15 variables:

    primary_key
    +
    +

    Value

    +

    a tibble with 15 variables:

    primary_key

    DrugBank id

    other_keys
    @@ -127,27 +108,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_groups.html b/docs/reference/drug_groups.html index 32cb3c7..ce1c7e8 100644 --- a/docs/reference/drug_groups.html +++ b/docs/reference/drug_groups.html @@ -1,77 +1,58 @@ -Drug Groups parser — drug_groups • dbparser - - -
    -
    -
    -
    -

    Drug Groups parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Groups parser

    + Source: R/drug_parsers.R +
    drug_groups.Rd
    -
    +

    Groups that this drug belongs to. May include any of: approved, vet_approved, nutraceutical, illicit, withdrawn, investigational, and experimental.

    -
    +
    +

    Usage

    drug_groups()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    group
    +
    +

    Value

    +

    a tibble with 2 variables:

    group
    drugbank_id
    @@ -80,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_interactions.html b/docs/reference/drug_interactions.html index a43cca8..1cbe6bf 100644 --- a/docs/reference/drug_interactions.html +++ b/docs/reference/drug_interactions.html @@ -1,81 +1,64 @@ -Drug Interactions parser — drug_interactions • dbparserDrug Interactions parser — drug_interactions • dbparser - - -
    -
    -
    -
    -

    Drug Interactions parser

    - Source: R/drug_parsers.R - + + + + + +
    +
    +
    +
    +

    Drug Interactions parser

    + Source: R/drug_parsers.R +
    drug_interactions.Rd
    -
    +

    Drug-drug interactions detailing drugs that, when administered concomitantly with the drug of interest, will affect its activity or result in adverse effects. These interactions may be synergistic or antagonistic depending on the physiological effects and mechanism of action of each drug.

    -
    +
    +

    Usage

    drug_interactions()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    drugbank-id
    +
    +

    Value

    +

    a tibble with the following variables:

    drugbank-id

    DrugBank ID of the interacting drug.

    name
    @@ -91,27 +74,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_intern_brand.html b/docs/reference/drug_intern_brand.html index a50ab70..fa2f976 100644 --- a/docs/reference/drug_intern_brand.html +++ b/docs/reference/drug_intern_brand.html @@ -1,79 +1,61 @@ -Drug International Brands parser — drug_intern_brand • dbparserDrug International Brands parser — drug_intern_brand • dbparser - - -
    -
    -
    -
    -

    Drug International Brands parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug International Brands parser

    + Source: R/drug_parsers.R +
    drug_intern_brand.Rd
    -
    +

    The proprietary names used by the manufacturers for commercially available forms of the drug, focusing on brand names for products that are available in countries other than Canada and the Unites States.

    -
    +
    +

    Usage

    drug_intern_brand()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    brand
    +
    +

    Value

    +

    a tibble with 4 variables:

    brand

    The proprietary, well-known name for given to this drug by a manufacturer.

    @@ -86,27 +68,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_manufacturers.html b/docs/reference/drug_manufacturers.html index f862781..54eb47c 100644 --- a/docs/reference/drug_manufacturers.html +++ b/docs/reference/drug_manufacturers.html @@ -1,77 +1,58 @@ -Drug Manufacturers parser — drug_manufacturers • dbparser - - -
    -
    -
    -
    -

    Drug Manufacturers parser

    - Source: R/drug_manufacturer_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Manufacturers parser

    + Source: R/drug_manufacturer_node_parser.R +
    drug_manufacturers.Rd
    -
    +

    A list of companies that are manufacturing the commercially available forms of this drug that are available in Canada and the Unites States.

    -
    +
    +

    Usage

    drug_manufacturers()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    generic
    +
    +

    Value

    +

    a tibble with the following variables:

    generic

    A list of companies that are manufacturing the generic form of the drug.

    @@ -84,27 +65,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_mixtures.html b/docs/reference/drug_mixtures.html index 3d71279..df19758 100644 --- a/docs/reference/drug_mixtures.html +++ b/docs/reference/drug_mixtures.html @@ -1,77 +1,58 @@ -Drug Mixtures parser — drug_mixtures • dbparser - - -
    -
    -
    -
    -

    Drug Mixtures parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Mixtures parser

    + Source: R/drug_parsers.R +
    drug_mixtures.Rd
    -
    +

    All commercially available products in which this drug is available in combination with other drug molecules

    -
    +
    +

    Usage

    drug_mixtures()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    name
    +
    +

    Value

    +

    a tibble with 4 variables:

    name

    The proprietary name provided by the manufacturer for this combination product.

    @@ -89,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_node_options.html b/docs/reference/drug_node_options.html index 5cd6c08..332e096 100644 --- a/docs/reference/drug_node_options.html +++ b/docs/reference/drug_node_options.html @@ -1,105 +1,83 @@ -returns drug node valid options. — drug_node_options • dbparser - - -
    -
    -
    -
    -

    returns drug node valid options.

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    returns drug node valid options.

    + Source: R/drugbank_parser.R +
    drug_node_options.Rd
    -
    +

    returns drug node valid options.

    -
    +
    +

    Usage

    drug_node_options()
    -
    -

    Value

    - - -

    list of drug valid options

    +
    +

    Value

    +

    list of drug valid options

    - - -
    +
    -
    + - - diff --git a/docs/reference/drug_packagers.html b/docs/reference/drug_packagers.html index 86525bc..dfbca3f 100644 --- a/docs/reference/drug_packagers.html +++ b/docs/reference/drug_packagers.html @@ -1,75 +1,55 @@ -Drug Packagers parser — drug_packagers • dbparser - - -
    -
    -
    -
    -

    Drug Packagers parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Packagers parser

    + Source: R/drug_parsers.R +
    drug_packagers.Rd
    -
    +

    A list of companies that are packaging the drug for re-distribution.

    -
    +
    +

    Usage

    drug_packagers()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    name
    +
    +

    Value

    +

    a tibble with 2 variables:

    name
    url
    @@ -82,27 +62,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_patents.html b/docs/reference/drug_patents.html index 02a9baf..9e17c68 100644 --- a/docs/reference/drug_patents.html +++ b/docs/reference/drug_patents.html @@ -1,79 +1,52 @@ -Drug Patents parser +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents • dbparser - - -
    -
    - - - -
    -
    -
    -

    Drug Patents parser -A property right issued by the United States Patent and Trademark -Office (USPTO) to an inventor for a limited time, in exchange for public -disclosure of the invention when the patent is granted. Drugs may be issued -multiple patents.

    - Source: R/drug_parsers.R - + +
    +
    +
    +

    Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents.

    + Source: R/drug_parsers.R +
    drug_patents.Rd
    -
    +

    Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public @@ -81,15 +54,14 @@

    Drug Patents parser multiple patents.

    -
    +
    +

    Usage

    drug_patents()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    number
    +
    +

    Value

    +

    a tibble with the following variables:

    number

    The patent number(s) associated with the drug.

    country
    @@ -112,27 +84,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pathway.html b/docs/reference/drug_pathway.html index 09352be..862f471 100644 --- a/docs/reference/drug_pathway.html +++ b/docs/reference/drug_pathway.html @@ -1,77 +1,58 @@ -Drug Pathway parser — drug_pathway • dbparser - - -
    -
    -
    -
    -

    Drug Pathway parser

    - Source: R/drug_pathway_node_parsers.R - + + + +
    +
    +
    +
    +

    Drug Pathway parser

    + Source: R/drug_pathway_node_parsers.R +
    drug_pathway.Rd
    -
    +

    Metabolic, disease, and biological pathways that the drug is involved in, as identified by the Small Molecule Protein Database (SMPDB).

    -
    +
    +

    Usage

    drug_pathway()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    smpdb-id
    +
    +

    Value

    +

    a tibble with the following variables:

    smpdb-id

    Small Molecule Pathway Database identifier for this pathway.

    @@ -87,27 +68,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pathway_drugs.html b/docs/reference/drug_pathway_drugs.html index 230cae9..2960131 100644 --- a/docs/reference/drug_pathway_drugs.html +++ b/docs/reference/drug_pathway_drugs.html @@ -1,98 +1,74 @@ -Drug Pathway Drugs parser — drug_pathway_drugs • dbparser - - -
    -
    -
    -
    -

    Drug Pathway Drugs parser

    - Source: R/drug_pathway_node_parsers.R - + + + +
    +
    +
    +
    +

    Drug Pathway Drugs parser

    + Source: R/drug_pathway_node_parsers.R +
    drug_pathway_drugs.Rd
    -
    +

    Drugs involved in this pathway.

    -
    +
    +

    Usage

    drug_pathway_drugs()
    -
    -

    Value

    - - -

    a tibble with pathway drugs properties

    +
    +

    Value

    +

    a tibble with pathway drugs properties

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pathway_enzyme.html b/docs/reference/drug_pathway_enzyme.html index c830b46..91a31bb 100644 --- a/docs/reference/drug_pathway_enzyme.html +++ b/docs/reference/drug_pathway_enzyme.html @@ -1,98 +1,74 @@ -Drug Pathway Enzymes parser — drug_pathway_enzyme • dbparser - - -
    -
    -
    -
    -

    Drug Pathway Enzymes parser

    - Source: R/drug_pathway_node_parsers.R - + + + +
    +
    +
    +
    +

    Drug Pathway Enzymes parser

    + Source: R/drug_pathway_node_parsers.R +
    drug_pathway_enzyme.Rd
    -
    +

    Enzymes involved in this pathway.

    -
    +
    +

    Usage

    drug_pathway_enzyme()
    -
    -

    Value

    - - -

    a tibble with pathway properties

    +
    +

    Value

    +

    a tibble with pathway properties

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pdb_entries.html b/docs/reference/drug_pdb_entries.html index 21f2ec6..f2a6b93 100644 --- a/docs/reference/drug_pdb_entries.html +++ b/docs/reference/drug_pdb_entries.html @@ -1,75 +1,55 @@ -Drug pdb-entries parser — drug_pdb_entries • dbparser - - -
    -
    -
    -
    -

    Drug pdb-entries parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug pdb-entries parser

    + Source: R/drug_parsers.R +
    drug_pdb_entries.Rd
    -
    +

    Protein Data Bank (PDB) identifiers for this drug.

    -
    +
    +

    Usage

    drug_pdb_entries()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    pdb-entry
    +
    +

    Value

    +

    a tibble with the following variables:

    pdb-entry
    drugbank_id
    @@ -78,27 +58,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pharmacology.html b/docs/reference/drug_pharmacology.html index 87f8596..9fb1fc4 100644 --- a/docs/reference/drug_pharmacology.html +++ b/docs/reference/drug_pharmacology.html @@ -1,77 +1,58 @@ -Drug Pharmacology parser — drug_pharmacology • dbparser - - -
    -
    -
    -
    -

    Drug Pharmacology parser

    - Source: R/drug_pharmacology_parser.R - + + + +
    +
    +
    +
    +

    Drug Pharmacology parser

    + Source: R/drug_pharmacology_parser.R +
    drug_pharmacology.Rd
    -
    +

    Describes the use, mechanism of action, pharmacokinetics, pharmacodynamics, and physiological or biochemical effects in the body.

    -
    +
    +

    Usage

    drug_pharmacology()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    indication
    +
    +

    Value

    +

    a tibble with the following variables:

    indication

    The approved conditions, diseases, or states for which a drug can safely and effectively be used. An indication is considered to be FDA-approved when it has any of the following designations: NDA, ANDA, BLA, @@ -142,27 +123,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_prices.html b/docs/reference/drug_prices.html index efcdba6..3135967 100644 --- a/docs/reference/drug_prices.html +++ b/docs/reference/drug_prices.html @@ -1,75 +1,55 @@ -Drug Prices Parsers — drug_prices • dbparser - - -
    -
    -
    -
    -

    Drug Prices Parsers

    - Source: R/drug_price_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Prices Parsers

    + Source: R/drug_price_node_parser.R +
    drug_prices.Rd
    -
    +

    Unit drug prices

    -
    +
    +

    Usage

    drug_prices()
    -
    -

    Value

    - - -

    a tibble with 5 variables:

    description
    +
    +

    Value

    +

    a tibble with 5 variables:

    description
    cost
    @@ -87,27 +67,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_products.html b/docs/reference/drug_products.html index f74d278..0aa7393 100644 --- a/docs/reference/drug_products.html +++ b/docs/reference/drug_products.html @@ -1,77 +1,58 @@ -Drug Products parser — drug_products • dbparser - - -
    -
    -
    -
    -

    Drug Products parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Products parser

    + Source: R/drug_parsers.R +
    drug_products.Rd
    -
    +

    A list of commercially available products in Canada and the United States that contain the drug.

    -
    +
    +

    Usage

    drug_products()
    -
    -

    Value

    - - -

    a tibble with 32 variables:

    name
    +
    +

    Value

    +

    a tibble with 32 variables:

    name

    The proprietary name(s) provided by the manufacturer for any commercially available products containing this drug.

    @@ -191,27 +172,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_reactions.html b/docs/reference/drug_reactions.html index 3f28b5d..e51553b 100644 --- a/docs/reference/drug_reactions.html +++ b/docs/reference/drug_reactions.html @@ -1,67 +1,52 @@ -Drug Reactions Parsers — drug_reactions • dbparserDrug Reactions Parsers — drug_reactions • dbparser - - -
    -
    -
    -
    -

    Drug Reactions Parsers

    - Source: R/drug_reaction_node_parser.R - + + + + + +
    +
    +
    +
    +

    Drug Reactions Parsers

    + Source: R/drug_reaction_node_parser.R +
    drug_reactions.Rd
    -
    +

    Extract the sequential representation of the metabolic reactions that this drug molecule is involved in. Depending on available information, this may include metabolizing enzymes, reaction type, substrates, products, @@ -69,15 +54,14 @@

    Drug Reactions Parsers

    the biochemical reactions.

    -
    +
    +

    Usage

    drug_reactions()
    -
    -

    Value

    - - -

    a tibble with 5 variables:

    sequence
    +
    +

    Value

    +

    a tibble with 5 variables:

    sequence

    Reactions are displayed within a numerical sequence

    left_drugbank_name
    @@ -100,27 +84,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_reactions_enzymes.html b/docs/reference/drug_reactions_enzymes.html index af6fda5..e20bf31 100644 --- a/docs/reference/drug_reactions_enzymes.html +++ b/docs/reference/drug_reactions_enzymes.html @@ -1,75 +1,55 @@ -Drug Reactions Enzymes Parsers — drug_reactions_enzymes • dbparser - - -
    -
    -
    -
    -

    Drug Reactions Enzymes Parsers

    - Source: R/drug_reaction_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Reactions Enzymes Parsers

    + Source: R/drug_reaction_node_parser.R +
    drug_reactions_enzymes.Rd
    -
    +

    Enzymes involved in metabolizing this drug

    -
    +
    +

    Usage

    drug_reactions_enzymes()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    name
    +
    +

    Value

    +

    a tibble with 3 variables:

    name
    uniprot-id
    @@ -81,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_salts.html b/docs/reference/drug_salts.html index 5ebe6e8..5c7bc44 100644 --- a/docs/reference/drug_salts.html +++ b/docs/reference/drug_salts.html @@ -1,79 +1,61 @@ -Drug Salts parser — drug_salts • dbparserDrug Salts parser — drug_salts • dbparser - - -
    -
    -
    -
    -

    Drug Salts parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Salts parser

    + Source: R/drug_parsers.R +
    drug_salts.Rd
    -
    +

    Available salt forms of the drug. Ions such as hydrochloride, sodium, and sulfate are often added to the drug molecule to increase solubility, dissolution, or absorption.

    -
    +
    +

    Usage

    drug_salts()
    -
    -

    Value

    - - -

    a tibble with 1 variables:

    drugbank-id
    +
    +

    Value

    +

    a tibble with 1 variables:

    drugbank-id

    DrugBank identifiers of the available salt form(s).

    name
    @@ -117,27 +99,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_sequences.html b/docs/reference/drug_sequences.html index f78cf0b..d366ce3 100644 --- a/docs/reference/drug_sequences.html +++ b/docs/reference/drug_sequences.html @@ -1,75 +1,55 @@ -Drug Sequences parser — drug_sequences • dbparser - - -
    -
    -
    -
    -

    Drug Sequences parser

    - Source: R/drug_sequence_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Sequences parser

    + Source: R/drug_sequence_node_parser.R +
    drug_sequences.Rd
    -
    +

    The amino acid sequence; provided if the drug is a peptide.

    -
    +
    +

    Usage

    drug_sequences()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    sequence
    +
    +

    Value

    +

    a tibble with the following variables:

    sequence

    a textual representation of the sequence

    format
    @@ -80,32 +60,28 @@

    Value

    -
    -

    Details

    +
    +

    Details

    Describes peptide sequences of biotech drugs

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_snp_adverse_reactions.html b/docs/reference/drug_snp_adverse_reactions.html index 2e94701..7508da2 100644 --- a/docs/reference/drug_snp_adverse_reactions.html +++ b/docs/reference/drug_snp_adverse_reactions.html @@ -1,77 +1,58 @@ -Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions • dbparser - - -
    -
    -
    -
    -

    Drug SNP Adverse Drug Reactions parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug SNP Adverse Drug Reactions parser

    + Source: R/drug_parsers.R +
    drug_snp_adverse_reactions.Rd
    -
    +

    The adverse drug reactions that may occur as a result of the listed single nucleotide polymorphisms (SNPs)

    -
    +
    +

    Usage

    drug_snp_adverse_reactions()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    protein-name
    +
    +

    Value

    +

    a tibble with the following variables:

    protein-name

    Proteins involved in this SNP.

    gene-symbol
    @@ -103,27 +84,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_snp_effects.html b/docs/reference/drug_snp_effects.html index 2f862f5..ab372da 100644 --- a/docs/reference/drug_snp_effects.html +++ b/docs/reference/drug_snp_effects.html @@ -1,79 +1,61 @@ -Drug SNP Effects parser — drug_snp_effects • dbparserDrug SNP Effects parser — drug_snp_effects • dbparser - - -
    -
    -
    -
    -

    Drug SNP Effects parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug SNP Effects parser

    + Source: R/drug_parsers.R +
    drug_snp_effects.Rd
    -
    +

    A list of single nucleotide polymorphisms (SNPs) relevant to drug activity or metabolism, and the effects these may have on pharmacological activity. SNP effects in the patient may require close monitoring, an increase or

    -
    +
    +

    Usage

    drug_snp_effects()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    protein-name
    +
    +

    Value

    +

    a tibble with the following variables:

    protein-name

    Proteins involved in this SNP.

    gene-symbol
    @@ -105,27 +87,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_syn.html b/docs/reference/drug_syn.html index 652548b..477ee05 100644 --- a/docs/reference/drug_syn.html +++ b/docs/reference/drug_syn.html @@ -1,75 +1,55 @@ -Drug Synonyms parser — drug_syn • dbparser - - -
    -
    -
    -
    -

    Drug Synonyms parser

    - Source: R/drug_synonym_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Synonyms parser

    + Source: R/drug_synonym_node_parser.R +
    drug_syn.Rd
    -
    +

    Other names or identifiers that are associated with this drug.

    -
    +
    +

    Usage

    drug_syn()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    language
    +
    +

    Value

    +

    a tibble with 3 variables:

    language

    Names of the drug in languages other than English.

    coder
    @@ -84,27 +64,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/enzymes.html b/docs/reference/enzymes.html index 2172398..c4ba25d 100644 --- a/docs/reference/enzymes.html +++ b/docs/reference/enzymes.html @@ -1,261 +1,8 @@ - - - + - - - - -Extracts the drug enzymes element and return data as tibble. — enzymes • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes returns tibble of drug enzymes elements.

    -
    - - 
    enzymes(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_articles(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes()
-
-# will throw an error, as database_connection is NULL
-enzymes(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes(save_table = TRUE, save_csv = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_actions.html b/docs/reference/enzymes_actions.html index 957afc5..49c4d12 100644 --- a/docs/reference/enzymes_actions.html +++ b/docs/reference/enzymes_actions.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug enzymes actions element and return data as tibble. — enzymes_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes actions element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_actions returns tibble of drug enzymes -actions elements.

    -
    - - 
    enzymes_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes actions node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes actions element of drug node in - DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_articles(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_actions()
-
-# will throw an error, as database_connection is NULL
-enzymes_actions(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes_actions(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_actions(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_actions(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_articles.html b/docs/reference/enzymes_articles.html index 6c74714..b95e027 100644 --- a/docs/reference/enzymes_articles.html +++ b/docs/reference/enzymes_articles.html @@ -1,267 +1,8 @@ - - - + - - - - -Extracts the drug enzymes articles element and return data as tibble. — enzymes_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes articles element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_articles returns tibble of drug enzymes -articles elements.

    -
    - - 
    enzymes_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes articles node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes articles element of drug node in drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_articles()
-
-# will throw an error, as database_connection is NULL
-enzymes_articles(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes_articles(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_articles(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_links.html b/docs/reference/enzymes_links.html index 08b52cc..b768dff 100644 --- a/docs/reference/enzymes_links.html +++ b/docs/reference/enzymes_links.html @@ -1,261 +1,8 @@ - - - + - - - - -Extracts the drug enzymes links element and return data as tibble. — enzymes_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes links element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_links returns tibble of drug enzymes links -elements.

    -
    - - 
    enzymes_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes links node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes links element of drug node in -DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_articles(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_links()
-
-# will throw an error, as database_connection is NULL
-enzymes_links(save_table = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_links(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_links(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_textbooks.html b/docs/reference/enzymes_textbooks.html index b6ded56..088dfba 100644 --- a/docs/reference/enzymes_textbooks.html +++ b/docs/reference/enzymes_textbooks.html @@ -1,268 +1,8 @@ - - - + - - - - -Extracts the drug enzymes textbooks element and return data as tibble. — enzymes_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes textbooks element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_textbooks returns tibble of drug enzymes -textbooks elements.

    -
    - - 
    enzymes_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes textbooks element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_articles(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_textbooks()
-
-# will throw an error, as database_connection is NULL
-enzymes_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_textbooks(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_textbooks(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/index.html b/docs/reference/index.html index d48705b..ca42730 100644 --- a/docs/reference/index.html +++ b/docs/reference/index.html @@ -1,111 +1,170 @@ -Function reference • dbparser - - -
    -
    -
    -
    -

    Reference

    + +
    +
    +
    +
    +

    Package index

    - - - - - - - - - - - - -
    -

    Drugs Databases Parser

    -

    Parse public drug databases and converted them into dvobject

    -
    -

    cett_nodes_options()

    -

    returns carriers, enzymes,targets and transporters node valid options.

    -

    drug_node_options()

    -

    returns drug node valid options.

    -

    parseDrugBank()

    -

    parseDrugBank

    -

    references_node_options()

    -

    returns references node valid options.

    -

    Utility functions

    -

    Different functions to handle dvobject

    -
    -

    show_dvobject_metadata()

    -

    init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes

    - - -
    +
    +

    Drugs Databases Parser

    + +

    Parse public drug databases and converted them into dvobject

    + +
    + + + + +
    + + cett_nodes_options() + +
    +
    returns carriers, enzymes,targets and transporters node valid options.
    + +
    + + drug_node_options() + +
    +
    returns drug node valid options.
    + +
    + + parseDrugBank() + +
    +
    parseDrugBank
    + +
    + + parseOnSIDES() + +
    +
    Parse the OnSIDES Core Relational Database
    + +
    + + parseTWOSIDES() + +
    +
    Parse the TWOSIDES Drug-Drug Interaction Database
    + +
    + references_node_options() -
    +
    returns references node valid options.
    +
    +

    Utility functions

    + +

    Different functions to handle dvobject

    + +
    + + + + +
    + + add_database_info() + +
    +
    add_database_info Assign passed databases db metadata to passed dvobject
    + +
    + + show_dvobject_metadata() + +
    +
    Display dvobject Metadata
    + +
    + + subset_drugbank_dvobject() + +
    +
    Subset a DrugBank dvobject by a vector of DrugBank IDs
    + +
    + + subset_onsides_dvobject() + +
    +
    Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware)
    +
    +

    Merge functions

    + +

    Different functions to merge different types of dvobjects

    + +
    + + + + +
    + + merge_drugbank_onsides() + +
    +
    Merge DrugBank and OnSIDES Database Objects
    + +
    + + merge_drugbank_twosides() + +
    +
    Merge a DrugBank dvobject with a TWOSIDES dvobject
    +
    +
    + + +
    +
    + - - diff --git a/docs/reference/init_dvobject.html b/docs/reference/init_dvobject.html index 3ef7a07..6cc97c7 100644 --- a/docs/reference/init_dvobject.html +++ b/docs/reference/init_dvobject.html @@ -1,103 +1,77 @@ -init_dvobject - initialize dvobject — init_dvobject • dbparser - - -
    -
    -
    -
    -

    init_dvobject - initialize dvobject

    - Source: R/dvobject_metadata.R - + + + +
    +
    +
    +
    +

    init_dvobject initialize dvobject

    + Source: R/dvobject_metadata.R +
    init_dvobject.Rd
    -
    +

    init_dvobject initialize dvobject

    -
    +
    +

    Usage

    init_dvobject()
    -
    -

    Value

    - - -

    dvobject

    +
    +

    Value

    +

    dvobject

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/links.html b/docs/reference/links.html index 2cbfc56..3396324 100644 --- a/docs/reference/links.html +++ b/docs/reference/links.html @@ -1,69 +1,52 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser

    + Source: R/references_parsers.R +
    links.Rd
    -
    +

    Return a list of websites that were used as references for Drugs/ Carriers/ Enzymes/ Targets/ Transporters

    -
    +
    +

    Usage

    drugs_links()
 
 carriers_links()
@@ -75,11 +58,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser
    
 transporters_links()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Name of the source website

    title
    @@ -94,27 +75,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/parseDrugBank.html b/docs/reference/parseDrugBank.html index 0d247fc..05ea9ea 100644 --- a/docs/reference/parseDrugBank.html +++ b/docs/reference/parseDrugBank.html @@ -1,71 +1,55 @@ -parseDrugBank — parseDrugBank • dbparserparseDrugBank — parseDrugBank • dbparser - - -
    -
    -
    -
    -

    parseDrugBank

    - Source: R/drugbank_parser.R - + +
    +
    +
    +
    +

    parseDrugBank

    + Source: R/drugbank_parser.R +
    parseDrugBank.Rd
    -
    +

    parses given DrugBank XML database into a dvobject. dvobject is a list of data.frames in which each data.frame represents a part of parsed data (i.e drugs, prices, carriers, ...)

    -
    +
    +

    Usage

    parseDrugBank(
   db_path,
   drug_options = NULL,
@@ -76,75 +60,73 @@ 
    parseDrugBank
    
 )
    -
    -

    Arguments

    -
    db_path
    +
    +

    Arguments

    + + +
    db_path

    string, full path for the DrugBank xml or zip file.

    -
    drug_options
    +
    drug_options

    character vector, list of sub drug related nodes names options to parse (default = NULL). Check drug_node_options() for all available options. If its value is `NULL` ONLY `drug_general_information` will be placed in the returned dvobject.

    -
    parse_salts
    +
    parse_salts

    boolean, parse salts info (default = FALSE)

    -
    parse_products
    +
    parse_products

    boolean, parse products info (default = FALSE)

    -
    references_options
    +
    references_options

    character vector, list of sub references related nodes names options to parse (default = NULL). Check references_node_options() for all available options.

    -
    cett_options
    +
    cett_options

    character vector, list of sub cett related nodes names options to parse (default = NULL). Check cett_nodes_options() for all available options.

    -
    -

    Value

    - - -

    dvobject

    +
    +

    Value

    +

    dvobject

    - - -
    +
    -
    + - - diff --git a/docs/reference/parse_cett_node.html b/docs/reference/parse_cett_node.html index fd7e992..818b916 100644 --- a/docs/reference/parse_cett_node.html +++ b/docs/reference/parse_cett_node.html @@ -1,100 +1,77 @@ -Run all CETT related parsers — parse_cett_node • dbparser - - -
    -
    -
    -
    -

    Run all CETT related parsers

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    Run all CETT related parsers

    + Source: R/drugbank_parser.R +
    parse_cett_node.Rd
    -
    +

    Run all parsers that retrieve carriers, enzymes, targets and transporters related information

    -
    +
    +

    Usage

    parse_cett_node(cett_options)
    -
    -

    Value

    - - -

    a list of all drugs parsed tibbles

    +
    +

    Value

    +

    a list of all drugs parsed tibbles

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/parse_drug_nodes.html b/docs/reference/parse_drug_nodes.html index 1a7b025..6eec6f5 100644 --- a/docs/reference/parse_drug_nodes.html +++ b/docs/reference/parse_drug_nodes.html @@ -1,104 +1,82 @@ -Run all drug related parsers — parse_drug_nodes • dbparser - - -
    -
    -
    -
    -

    Run all drug related parsers

    - Source: R/drugbank_parser.R - + +
    +
    +
    +
    +

    Run all drug related parsers

    + Source: R/drugbank_parser.R +
    parse_drug_nodes.Rd
    -
    +

    Run all parsers that retrieve drugs related information

    -
    +
    +

    Usage

    parse_drug_nodes(drug_options)
    -
    -

    Arguments

    -
    drug_options
    +
    +

    Arguments

    + + +
    drug_options

    - list of options to parse

    -
    -

    Value

    - - -

    a list of all drugs parsed tibbles

    +
    +

    Value

    +

    a list of all drugs parsed tibbles

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/parse_references_node.html b/docs/reference/parse_references_node.html index 0c29c72..4f9d88a 100644 --- a/docs/reference/parse_references_node.html +++ b/docs/reference/parse_references_node.html @@ -1,99 +1,75 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser

    + Source: R/drugbank_parser.R +
    parse_references_node.Rd
    -
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser

    -
    +
    +

    Usage

    parse_references_node(references_options)
    -
    -

    Value

    - - -

    a list of all references for drugs, carriers, enzymes, targets or +

    +

    Value

    +

    a list of all references for drugs, carriers, enzymes, targets or transporters

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/read_drugbank_xml_db.html b/docs/reference/read_drugbank_xml_db.html index 77d0900..407c834 100644 --- a/docs/reference/read_drugbank_xml_db.html +++ b/docs/reference/read_drugbank_xml_db.html @@ -1,114 +1,93 @@ -Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db • dbparser - - -
    -
    -
    -
    -

    Reads DrugBank xml database and load it into memory.

    - Source: R/drug_common_utilities.R - + +
    +
    +
    +
    +

    Reads DrugBank xml database and load it into memory.

    + Source: R/drug_common_utilities.R +
    read_drugbank_xml_db.Rd
    -
    +

    read_drugbank_xml_db loads DrugBank xml database full tree into memory.

    -
    +
    +

    Usage

    read_drugbank_xml_db(db_path)
    -
    -

    Arguments

    -
    db_path
    +
    +

    Arguments

    + + +
    db_path

    string, full path for the DrugBank xml or zip file.

    -
    -

    Value

    - - -

    loaded DB or NULL

    +
    +

    Value

    +

    loaded DB or NULL

    -
    -

    Details

    +
    +

    Details

    This functions reads DrugBank xml database and load it into memory for later processing. Hence; this method must be called before any other function in the package and it needs to be called one time only.

    It takes one single mandatory argument which is the location of DrugBank db.

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/references_node_options.html b/docs/reference/references_node_options.html index be939ed..53aaf52 100644 --- a/docs/reference/references_node_options.html +++ b/docs/reference/references_node_options.html @@ -1,105 +1,83 @@ -returns references node valid options. — references_node_options • dbparser - - -
    -
    -
    -
    -

    returns references node valid options.

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    returns references node valid options.

    + Source: R/drugbank_parser.R +
    references_node_options.Rd
    -
    +

    returns references node valid options.

    -
    +
    +

    Usage

    references_node_options()
    -
    -

    Value

    - - -

    list of references valid options

    +
    +

    Value

    +

    list of references valid options

    -
    -

    See also

    -

    Other parsers: -cett_nodes_options(), -drug_node_options(), -parseDrugBank()

    +
    +

    See also

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseOnSIDES(), +parseTWOSIDES()

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/show_dvobject_metadata.html b/docs/reference/show_dvobject_metadata.html index 0a0b9a5..50d37f5 100644 --- a/docs/reference/show_dvobject_metadata.html +++ b/docs/reference/show_dvobject_metadata.html @@ -1,109 +1,106 @@ -init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes — show_dvobject_metadata • dbparser - - -
    -
    -
    -
    -

    init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes

    - Source: R/dvobject_metadata.R - + + + + + + +
    +
    +
    +
    +

    Display dvobject Metadata

    + Source: R/dvobject_metadata.R +
    show_dvobject_metadata.Rd
    -
    -

    init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes

    +
    +

    Displays information about passed dbobject object including basic info, +database metadata, and all data.frames contained within nested lists.

    -
    - 
    show_dvobject_metadata(dvobject)
    +
    +

    Usage

    + 
    show_dvobject_metadata(obj, return_df = FALSE)
    -
    -

    Arguments

    -
    dvobject
    -

    - dvobject list to show related metadata

    +
    +

    Arguments

    + + +
    obj
    +

    A dvobject

    -
    -
    -

    Value

    - -

    data.frame

    +
    return_df
    +

    Logical. If TRUE, returns metadata data.frame without printing. +Default is FALSE.

    + +
    +
    +

    Value

    +

    Invisibly returns a data.frame containing dvobject metadata

    +
    +
    +

    See also

    +

    Other utility: +add_database_info(), +subset_drugbank_dvobject(), +subset_onsides_dvobject()

    -
    - -
    +
    +

    Examples

    + 
    if (FALSE) { # \dontrun{
+display_merged_db_attrs(drugbank)
+metadata <- display_merged_db_attrs(drugbank, return_df = TRUE)
+} # }
+
+
    +
    +
    -
    + - - diff --git a/docs/reference/targets.html b/docs/reference/targets.html index cdfb333..c4ba25d 100644 --- a/docs/reference/targets.html +++ b/docs/reference/targets.html @@ -1,261 +1,8 @@ - - - + - - - - -Extracts the drug targ element and return data as tibble. — targets • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets returns tibble of drug targ elements.

    -
    - - 
    targets(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug target node attributes date frame

    -

    Details

    - -

    This functions extracts the target element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_articles(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets()
-
-# will throw an error, as database_connection is NULL
-targets(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets(save_table = TRUE, save_csv = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-#  location and return parsed tibble.
-# If the csv exist override it and return it.
-targets(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_actions.html b/docs/reference/targets_actions.html index 6fdd756..49c4d12 100644 --- a/docs/reference/targets_actions.html +++ b/docs/reference/targets_actions.html @@ -1,264 +1,8 @@ - - - + - - - - -Extracts the drug targ actions element and return data as tibble. — targets_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ actions element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_actions returns tibble of drug targ -actions elements.

    -
    - - 
    targets_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ actions node attributes date frame

    -

    Details

    - -

    This functions extracts the targ actions element of drug node in drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_articles(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_actions()
-
-# will throw an error, as database_connection is NULL
-targets_actions(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_actions(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_actions(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_actions(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_articles.html b/docs/reference/targets_articles.html index b2dba15..b95e027 100644 --- a/docs/reference/targets_articles.html +++ b/docs/reference/targets_articles.html @@ -1,267 +1,8 @@ - - - + - - - - -Extracts the drug targ articles element and return data as tibble. — targets_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ articles element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_articles returns tibble of drug targ -articles elements.

    -
    - - 
    targets_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ articles node attributes date frame

    -

    Details

    - -

    This functions extracts the targ articles element of drug node in drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_articles()
-
-# will throw an error, as database_connection is NULL
-targets_articles(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_articles(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_articles(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_links.html b/docs/reference/targets_links.html index c6cabd5..b768dff 100644 --- a/docs/reference/targets_links.html +++ b/docs/reference/targets_links.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug targ links element and return data as tibble. — targets_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ links element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_links returns tibble of drug targ links - elements.

    -
    - - 
    targets_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ_links node attributes date frame

    -

    Details

    - -

    This functions extracts the targ links element of drug node in -DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_articles(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_links()
-
-# will throw an error, as database_connection is NULL
-targets_links(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_links(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_links(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in
-#  current location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_links(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_textbooks.html b/docs/reference/targets_textbooks.html index b13f3e0..088dfba 100644 --- a/docs/reference/targets_textbooks.html +++ b/docs/reference/targets_textbooks.html @@ -1,268 +1,8 @@ - - - + - - - - -Extracts the drug targ textbooks element and return data as tibble. — targets_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ textbooks element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_textbooks returns tibble of drug - targ textbooks elements.

    -
    - - 
    targets_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the targ textbooks element of drug node in - drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_articles(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_textbooks()
-
-# will throw an error, as database_connection is NULL
-targets_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_textbooks(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_textbooks(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters.html b/docs/reference/transporters.html index d3ee597..c4ba25d 100644 --- a/docs/reference/transporters.html +++ b/docs/reference/transporters.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug transporters element and return data as tibble. — transporters • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters returns tibble of drug transporters -elements.

    -
    - - 
    transporters(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters element of drug node in - DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters()
-
-# will throw an error, as database_connection is NULL
-transporters(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in
-# current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_actions.html b/docs/reference/transporters_actions.html index fff9be3..49c4d12 100644 --- a/docs/reference/transporters_actions.html +++ b/docs/reference/transporters_actions.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug transporters actions element and return data as tibble. — transporters_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters actions element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters actions returns tibble of drug - transporters -actions elements.

    -
    - - 
    transporters_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters actions node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters actions element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_articles(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_actions()
-
-# will throw an error, as database_connection is NULL
-transporters_actions(save_table = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_actions(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location
-#  and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_actions(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_articles.html b/docs/reference/transporters_articles.html index 4134e36..b95e027 100644 --- a/docs/reference/transporters_articles.html +++ b/docs/reference/transporters_articles.html @@ -1,266 +1,8 @@ - - - + - - - - -Extracts the drug transporters articles element and return data as -tibble. — transporters_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters articles element and return data as -tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters articles returns tibble of drug -transporters articles elements.

    -
    - - 
    transporters_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters articles node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters articles element of drug node in - drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_articles()
-
-# will throw an error, as database_connection is NULL
-transporters_articles(save_table = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_articles(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_links.html b/docs/reference/transporters_links.html index 63fe685..b768dff 100644 --- a/docs/reference/transporters_links.html +++ b/docs/reference/transporters_links.html @@ -1,267 +1,8 @@ - - - + - - - - -Extracts the drug transporters links element and return data as tibble. — transporters_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters links element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters_links returns tibble of drug -transporters_links elements.

    -
    - - 
    transporters_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters links node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters links element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_links()
-
-# will throw an error, as database_connection is NULL
-transporters_links(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_links(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_links(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_polypep_ex_ident.html b/docs/reference/transporters_polypep_ex_ident.html index b0a6bde..7fd02f4 100644 --- a/docs/reference/transporters_polypep_ex_ident.html +++ b/docs/reference/transporters_polypep_ex_ident.html @@ -1,276 +1,8 @@ - - - + - - - - -Extracts the drug transporters polypeptides external identifiers - element and return data as tibble. — transporters_polypep_ex_ident • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters polypeptides external identifiers - element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters_polypep_ex_ident -returns tibble of drug transporters polypeptides external identifiers -elements.

    -
    - - 
    transporters_polypep_ex_ident(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters polypeptides external identifiers - node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters polypeptides external - identifiers element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_links(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_polypep_ex_ident()
-
-# will throw an error, as database_connection is NULL
-transporters_polypep_ex_ident(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_polypep_ex_ident(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_polypep_ex_ident(
-  save_table = TRUE, save_csv = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_polypep_ex_ident(
-  save_csv = TRUE, csv_path = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_polypep_ex_ident(
-  save_csv = TRUE, csv_path = TRUE, override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_textbooks.html b/docs/reference/transporters_textbooks.html index 4cbb198..088dfba 100644 --- a/docs/reference/transporters_textbooks.html +++ b/docs/reference/transporters_textbooks.html @@ -1,272 +1,8 @@ - - - + - - - - -Extracts the drug transporters textbooks element and return data as - tibble. — transporters_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters textbooks element and return data as - tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters_textbooks returns tibble of drug -transporters - textbooks elements.

    -
    - - 
    transporters_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters textbooks element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_textbooks()
-
-# will throw an error, as database_connection is NULL
-transporters_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_textbooks(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given location
-#  and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_textbooks(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/sitemap.xml b/docs/sitemap.xml index f654361..eda2e59 100644 --- a/docs/sitemap.xml +++ b/docs/sitemap.xml @@ -1,720 +1,231 @@ - - - - /404.html - - - /articles/Database_Saving.html - - - /articles/dbparser.html - - - /articles/index.html - - - /authors.html - - - /CODE_OF_CONDUCT.html - - - /CONTRIBUTING.html - - - /index.html - - - /LICENSE-text.html - - - /news/index.html - - - /reference/add_drugbank_info.html - - - /reference/articles.html - - - /reference/attachments.html - - - /reference/books.html - - - /reference/carriers.html - - - /reference/carriers_actions.html - - - /reference/carriers_articles.html - - - /reference/carriers_links.html - - - /reference/carriers_polypeptide.html - - - /reference/carriers_polypeptides_go.html - - - /reference/carriers_polypeptides_pfams.html - - - /reference/carriers_polypeptides_syn.html - - - /reference/carriers_polypeptide_ext_id.html - - - /reference/carriers_textbooks.html - - - /reference/cett.html - - - /reference/cett_actions_doc.html - - - /reference/cett_doc.html - - - /reference/cett_ex_identity_doc.html - - - /reference/cett_go_doc.html - - - /reference/cett_nodes_options.html - - - /reference/cett_poly_doc.html - - - /reference/cett_poly_pfms_doc.html - - - /reference/cett_poly_syn_doc.html - - - /reference/close_db.html - - - /reference/dbparser.html - - - /reference/drug.html - - - /reference/drugs.html - - - /reference/drug_affected_organisms.html - - - /reference/drug_ahfs_codes.html - - - /reference/drug_all.html - - - /reference/drug_articles.html - - - /reference/drug_atc_codes.html - - - /reference/drug_books.html - - - /reference/drug_calc_prop.html - - - /reference/drug_categories.html - - - /reference/drug_classification.html - - - /reference/drug_dosages.html - - - /reference/drug_element.html - - - /reference/drug_element_options.html - - - /reference/drug_exp_prop.html - - - /reference/drug_external_links.html - - - /reference/drug_ex_identity.html - - - /reference/drug_food_interactions.html - - - /reference/drug_general_information.html - - - /reference/drug_groups.html - - - /reference/drug_interactions.html - - - /reference/drug_intern_brand.html - - - /reference/drug_links.html - - - /reference/drug_manufacturers.html - - - /reference/drug_mixtures.html - - - /reference/drug_node_options.html - - - /reference/drug_packagers.html - - - /reference/drug_patents.html - - - /reference/drug_pathway.html - - - /reference/drug_pathway_drugs.html - - - /reference/drug_pathway_enzyme.html - - - /reference/drug_pdb_entries.html - - - /reference/drug_pharmacology.html - - - /reference/drug_prices.html - - - /reference/drug_products.html - - - /reference/drug_reactions.html - - - /reference/drug_reactions_enzymes.html - - - /reference/drug_salts.html - - - /reference/drug_sequences.html - - - /reference/drug_snp_adverse_reactions.html - - - /reference/drug_snp_effects.html - - - /reference/drug_syn.html - - - /reference/enzymes.html - - - /reference/enzymes_actions.html - - - /reference/enzymes_articles.html - - - /reference/enzymes_links.html - - - /reference/enzymes_polypeptide.html - - - /reference/enzymes_polypeptide_ext_ident.html - - - /reference/enzymes_polypeptide_go.html - - - /reference/enzymes_polypeptide_pfams.html - - - /reference/enzymes_polypeptide_syn.html - - - /reference/enzymes_textbooks.html - - - /reference/get_drugbank_exported_date.html - - - /reference/get_drugbank_metadata.html - - - /reference/get_drugbank_version.html - - - /reference/get_xml_db_rows.html - - - /reference/index.html - - - /reference/init_dvobject.html - - - /reference/links.html - - - /reference/open_db.html - - - /reference/open_mdb.html - - - /reference/parseDrugBank.html - - - /reference/parse_carr_poly.html - - - /reference/parse_carr_polypeptides_go.html - - - /reference/parse_carr_polypeptides_pfams.html - - - /reference/parse_carr_polypeptides_syn.html - - - /reference/parse_carr_poly_ext_identity.html - - - /reference/parse_cett_node.html - - - /reference/parse_drug.html - - - /reference/parse_drug_affected_organisms.html - - - /reference/parse_drug_ahfs_codes.html - - - /reference/parse_drug_all.html - - - /reference/parse_drug_articles.html - - - /reference/parse_drug_atc_codes.html - - - /reference/parse_drug_books.html - - - /reference/parse_drug_calculated_properties.html - - - /reference/parse_drug_calc_prop.html - - - /reference/parse_drug_carriers.html - - - /reference/parse_drug_carriers_actions.html - - - /reference/parse_drug_carriers_articles.html - - - /reference/parse_drug_carriers_links.html - - - /reference/parse_drug_carriers_polypeptides.html - - - /reference/parse_drug_carriers_polypeptides_external_identifiers.html - - - /reference/parse_drug_carriers_polypeptides_go_classifiers.html - - - /reference/parse_drug_carriers_polypeptides_pfams.html - - - /reference/parse_drug_carriers_polypeptides_synonyms.html - - - /reference/parse_drug_carriers_textbooks.html - - - /reference/parse_drug_categories.html - - - /reference/parse_drug_classification.html - - - /reference/parse_drug_classifications.html - - - /reference/parse_drug_dosages.html - - - /reference/parse_drug_element.html - - - /reference/parse_drug_element_options.html - - - /reference/parse_drug_enzymes.html - - - /reference/parse_drug_enzymes_actions.html - - - /reference/parse_drug_enzymes_articles.html - - - /reference/parse_drug_enzymes_links.html - - - /reference/parse_drug_enzymes_polypeptides.html - - - /reference/parse_drug_enzymes_polypeptides_external_identifiers.html - - - /reference/parse_drug_enzymes_polypeptides_go_classifiers.html - - - /reference/parse_drug_enzymes_polypeptides_pfams.html - - - /reference/parse_drug_enzymes_polypeptides_synonyms.html - - - /reference/parse_drug_enzymes_textbooks.html - - - /reference/parse_drug_experimental_properties.html - - - /reference/parse_drug_exp_prop.html - - - /reference/parse_drug_external_identifiers.html - - - 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a/man/add_database_info.Rd b/man/add_database_info.Rd index 19f97aa..031b26f 100644 --- a/man/add_database_info.Rd +++ b/man/add_database_info.Rd @@ -28,3 +28,10 @@ dvobject add_database_info Assign passed databases db metadata to passed dvobject } +\seealso{ +Other utility: +\code{\link{show_dvobject_metadata}()}, +\code{\link{subset_drugbank_dvobject}()}, +\code{\link{subset_onsides_dvobject}()} +} +\concept{utility} diff --git a/man/cett_nodes_options.Rd b/man/cett_nodes_options.Rd index 3106647..b0a5baf 100644 --- a/man/cett_nodes_options.Rd +++ b/man/cett_nodes_options.Rd @@ -17,6 +17,7 @@ Other parsers: \code{\link{drug_node_options}()}, \code{\link{parseDrugBank}()}, \code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/drug_node_options.Rd b/man/drug_node_options.Rd index 0b016ad..7f7d268 100644 --- a/man/drug_node_options.Rd +++ b/man/drug_node_options.Rd @@ -17,6 +17,7 @@ Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{parseDrugBank}()}, \code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/merge_drugbank_onsides.Rd b/man/merge_drugbank_onsides.Rd index 705e188..34b9475 100644 --- a/man/merge_drugbank_onsides.Rd +++ b/man/merge_drugbank_onsides.Rd @@ -63,3 +63,8 @@ targets_of_interest <- merged_db$targets \%>\% head(targets_of_interest) } } +\seealso{ +Other mergers: +\code{\link{merge_drugbank_twosides}()} +} +\concept{mergers} diff --git a/man/merge_drugbank_twosides.Rd b/man/merge_drugbank_twosides.Rd index 25e9b87..936c5d6 100644 --- a/man/merge_drugbank_twosides.Rd +++ b/man/merge_drugbank_twosides.Rd @@ -19,3 +19,8 @@ Integrates drug-drug interaction data from TWOSIDES with the rich mechanistic information from DrugBank. This function is chainable and can accept a raw DrugBank object or an already-merged dvobject. } +\seealso{ +Other mergers: +\code{\link{merge_drugbank_onsides}()} +} +\concept{mergers} diff --git a/man/parseDrugBank.Rd b/man/parseDrugBank.Rd index a97a00e..6f17ca8 100644 --- a/man/parseDrugBank.Rd +++ b/man/parseDrugBank.Rd @@ -47,6 +47,7 @@ Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, \code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/parseOnSIDES.Rd b/man/parseOnSIDES.Rd index 295a4f8..6a699b3 100644 --- a/man/parseOnSIDES.Rd +++ b/man/parseOnSIDES.Rd @@ -35,6 +35,14 @@ Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, \code{\link{parseDrugBank}()}, +\code{\link{parseTWOSIDES}()}, +\code{\link{references_node_options}()} + +Other parsers: +\code{\link{cett_nodes_options}()}, +\code{\link{drug_node_options}()}, +\code{\link{parseDrugBank}()}, +\code{\link{parseTWOSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/parseTWOSIDES.Rd b/man/parseTWOSIDES.Rd index 637cfbd..8e58b07 100644 --- a/man/parseTWOSIDES.Rd +++ b/man/parseTWOSIDES.Rd @@ -43,3 +43,12 @@ Database fields as follow: \item{mean_reporting_frequency}{Proportion of reports for the drug that report the side effect, A/(A+B)} } } +\seealso{ +Other parsers: +\code{\link{cett_nodes_options}()}, +\code{\link{drug_node_options}()}, +\code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, +\code{\link{references_node_options}()} +} +\concept{parsers} diff --git a/man/references_node_options.Rd b/man/references_node_options.Rd index bd5dd3a..e63417b 100644 --- a/man/references_node_options.Rd +++ b/man/references_node_options.Rd @@ -17,6 +17,7 @@ Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, \code{\link{parseDrugBank}()}, -\code{\link{parseOnSIDES}()} +\code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()} } \concept{parsers} diff --git a/man/show_dvobject_metadata.Rd b/man/show_dvobject_metadata.Rd index aaa3e24..4b9df2d 100644 --- a/man/show_dvobject_metadata.Rd +++ b/man/show_dvobject_metadata.Rd @@ -26,3 +26,10 @@ metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) } } +\seealso{ +Other utility: +\code{\link{add_database_info}()}, +\code{\link{subset_drugbank_dvobject}()}, +\code{\link{subset_onsides_dvobject}()} +} +\concept{utility} diff --git a/man/subset_drugbank_dvobject.Rd b/man/subset_drugbank_dvobject.Rd index e5fd8c6..6b0b56a 100644 --- a/man/subset_drugbank_dvobject.Rd +++ b/man/subset_drugbank_dvobject.Rd @@ -31,7 +31,9 @@ one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, } } \seealso{ -Other utils: +Other utility: +\code{\link{add_database_info}()}, +\code{\link{show_dvobject_metadata}()}, \code{\link{subset_onsides_dvobject}()} } -\concept{utils} +\concept{utility} diff --git a/man/subset_onsides_dvobject.Rd b/man/subset_onsides_dvobject.Rd index ebf9063..cce215b 100644 --- a/man/subset_onsides_dvobject.Rd +++ b/man/subset_onsides_dvobject.Rd @@ -19,7 +19,9 @@ Intelligently filters an OnSIDES dvobject by cascading filters through the relational tables, ensuring the final subset is self-consistent. } \seealso{ -Other utils: +Other utility: +\code{\link{add_database_info}()}, +\code{\link{show_dvobject_metadata}()}, \code{\link{subset_drugbank_dvobject}()} } -\concept{utils} +\concept{utility} From ed84a602c73042537625d4e790b30eae17523c0c Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 15:16:41 +0200 Subject: [PATCH 44/57] #186, update package website --- docs/404.md | 3 + docs/CODE_OF_CONDUCT.md | 81 + docs/CONTRIBUTING.md | 134 + docs/LICENSE-text.md | 4 + docs/articles/dbparser.md | 146 + docs/articles/dbparser_2_2.html | 174 + docs/articles/dbparser_2_2.md | 81 + .../canvasXpress-58.7/canvasXpress.css | 7655 +++++++++++ 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Please use links in the navbar. + +# Page not found (404) diff --git a/docs/CODE_OF_CONDUCT.md b/docs/CODE_OF_CONDUCT.md new file mode 100644 index 0000000..26d3018 --- /dev/null +++ b/docs/CODE_OF_CONDUCT.md @@ -0,0 +1,81 @@ +# Contributor Covenant Code of Conduct + +## Our Pledge + +In the interest of fostering an open and welcoming environment, we as +contributors and maintainers pledge to making participation in our +project and our community a harassment-free experience for everyone, +regardless of age, body size, disability, ethnicity, sex +characteristics, gender identity and expression, level of experience, +education, socio-economic status, nationality, personal appearance, +race, religion, or sexual identity and orientation. + +## Our Standards + +Examples of behavior that contributes to creating a positive environment +include: + +- Using welcoming and inclusive language +- Being respectful of differing viewpoints and experiences +- Gracefully accepting constructive criticism +- Focusing on what is best for the community +- Showing empathy towards other community members + +Examples of unacceptable behavior by participants include: + +- The use of sexualized language or imagery and unwelcome sexual + attention or advances +- Trolling, insulting/derogatory comments, and personal or political + attacks +- Public or private harassment +- Publishing others’ private information, such as a physical or + electronic address, without explicit permission +- Other conduct which could reasonably be considered inappropriate in a + professional setting + +## Our Responsibilities + +Project maintainers are responsible for clarifying the standards of +acceptable behavior and are expected to take appropriate and fair +corrective action in response to any instances of unacceptable behavior. + +Project maintainers have the right and responsibility to remove, edit, +or reject comments, commits, code, wiki edits, issues, and other +contributions that are not aligned to this Code of Conduct, or to ban +temporarily or permanently any contributor for other behaviors that they +deem inappropriate, threatening, offensive, or harmful. + +## Scope + +This Code of Conduct applies both within project spaces and in public +spaces when an individual is representing the project or its community. +Examples of representing a project or community include using an +official project e-mail address, posting via an official social media +account, or acting as an appointed representative at an online or +offline event. Representation of a project may be further defined and +clarified by project maintainers. + +## Enforcement + +Instances of abusive, harassing, or otherwise unacceptable behavior may +be reported by contacting the project team at +. All complaints will be reviewed and +investigated and will result in a response that is deemed necessary and +appropriate to the circumstances. The project team is obligated to +maintain confidentiality with regard to the reporter of an incident. +Further details of specific enforcement policies may be posted +separately. + +Project maintainers who do not follow or enforce the Code of Conduct in +good faith may face temporary or permanent repercussions as determined +by other members of the project’s leadership. + +## Attribution + +This Code of Conduct is adapted from the [Contributor +Covenant](https://www.contributor-covenant.org), version 1.4, available +at + + +For answers to common questions about this code of conduct, see + diff --git a/docs/CONTRIBUTING.md b/docs/CONTRIBUTING.md new file mode 100644 index 0000000..55b2558 --- /dev/null +++ b/docs/CONTRIBUTING.md @@ -0,0 +1,134 @@ +# Contributing to dbparser + +First of all, thanks for considering contributing to dbparser! 👍 It’s +people like you that make it rewarding for us - the project +maintainers - to work on dbparser. 😊 + +dbparser is an open source project, maintained by people who care. We +are not directly funded to do so. + +## Code of conduct + +Please note that this project is released with a [Contributor Code of +Conduct](https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.md). By +participating in this project you agree to abide by its terms. + +## How you can contribute + +There are several ways you can contribute to this project. If you want +to know more about why and how to contribute to open source projects +like this one, see this [Open Source +Guide](https://opensource.guide/how-to-contribute/). + +### Share the love ❤️ + +Think **dbparser** is useful? Let others discover it, by telling them in +person, via Twitter or a blog post. + +Using **dbparser** for a paper you are writing? Consider [citing +it](https://docs.ropensci.org/dbparser/authors.html). + +### Ask a question ⁉️ + +Using our_package and got stuck? Browse the +[documentation](https://docs.ropensci.org/dbparser/) to see if you can +find a solution. Still stuck? Post your question as an [issue on +GitHub](https://github.com/ropensci/dbparser/issues/new). While we +cannot offer user support, we’ll try to do our best to address it, as +questions often lead to better documentation or the discovery of bugs. + +Want to ask a question in private? Contact the package maintainer by +[email](https://docs.ropensci.org/dbparser/mohammed.ali@edu.dsti.institute). + +### Propose an idea 💡 + +Have an idea for a new our_package feature? Take a look at the +[documentation](https://docs.ropensci.org/dbparser/) and [issue +list](https://github.com/ropensci/dbparser/issues) to see if it isn’t +included or suggested yet. If not, suggest your idea as an [issue on +GitHub](https://github.com/ropensci/dbparser/issues/new). While we can’t +promise to implement your idea, it helps to: + +- Explain in detail how it would work. +- Keep the scope as narrow as possible. + +See below if you want to contribute code for your idea as well. + +### Report a bug 🐛 + +Using our_package and discovered a bug? That’s annoying! Don’t let +others have the same experience and report it as an [issue on +GitHub](https://github.com/ropensci/dbparser/issues/new) so we can fix +it. A good bug report makes it easier for us to do so, so please +include: + +- Your operating system name and version (e.g. Mac OS 10.13.6). +- Any details about your local setup that might be helpful in + troubleshooting. +- Detailed steps to reproduce the bug. + +### Improve the documentation 📖 + +Noticed a typo on the website? Think a function could use a better +example? Good documentation makes all the difference, so your help to +improve it is very welcome! + +#### The website + +[This website](https://docs.ropensci.org/dbparser/) is generated with +[`pkgdown`](http://pkgdown.r-lib.org/). That means we don’t have to +write any html: content is pulled together from documentation in the +code, vignettes, +[Markdown](https://guides.github.com/features/mastering-markdown/) +files, the package `DESCRIPTION` and `_pkgdown.yml` settings. If you +know your way around `pkgdown`, you can [propose a file +change](https://help.github.com/articles/editing-files-in-another-user-s-repository/) +to improve documentation. If not, [report an +issue](https://github.com/ropensci/dbparser/issues/new) and we can point +you in the right direction. + +#### Function documentation + +Functions are described as comments near their code and translated to +documentation using [`roxygen2`](https://klutometis.github.io/roxygen/). +If you want to improve a function description: + +1. Go to `R/` directory in the [code + repository](https://github.com/ropensci/dbparser). +2. Look for the file with the name of the function. +3. [Propose a file + change](https://help.github.com/articles/editing-files-in-another-user-s-repository/) + to update the function documentation in the roxygen comments + (starting with `#'`). + +### Contribute code 📝 + +Care to fix bugs or implement new functionality for our_package? +Awesome! 👏 Have a look at the [issue +list](https://github.com/ropensci/dbparser/issues) and leave a comment +on the things you want to work on. See also the development guidelines +below. + +## Development guidelines + +We try to follow the [GitHub +flow](https://guides.github.com/introduction/flow/) for development. + +1. Fork [this repo](https://github.com/ropensci/dbparser) and clone it + to your computer. To learn more about this process, see [this + guide](https://guides.github.com/activities/forking/). +2. If you have forked and cloned the project before and it has been a + while since you worked on it, [pull changes from the original + repo](https://help.github.com/articles/merging-an-upstream-repository-into-your-fork/) + to your clone by using `git pull upstream master`. +3. Open the RStudio project file (`.Rproj`). +4. Make your changes: + - Write your code. + - Test your code (bonus points for adding unit tests). + - Document your code (see function documentation above). + - Check your code with + [`devtools::check()`](https://devtools.r-lib.org/reference/check.html) + and aim for 0 errors and warnings. +5. Commit and push your changes. +6. Submit a [pull + request](https://guides.github.com/activities/forking/#making-a-pull-request). diff --git a/docs/LICENSE-text.md b/docs/LICENSE-text.md new file mode 100644 index 0000000..0415602 --- /dev/null +++ b/docs/LICENSE-text.md @@ -0,0 +1,4 @@ +# License + + YEAR: 2018 + COPYRIGHT HOLDER: Mohammed Ali, Ali Ezzat diff --git a/docs/articles/dbparser.md b/docs/articles/dbparser.md new file mode 100644 index 0000000..7a79421 --- /dev/null +++ b/docs/articles/dbparser.md @@ -0,0 +1,146 @@ +# Unlocking DrugBank: Parsing and Visualizing Mechanistic Data + +## Introduction + +The **DrugBank** database is the global gold standard for drug +information, containing rich data on chemical structures, pharmacology, +and molecular targets. However, the raw data is provided as a massive, +complex XML file that is difficult to use in statistical analysis. + +`dbparser` solves this problem. It transforms that complex XML into a +**Drugverse Object (`dvobject`)**—a structured collection of R data +frames ready for analysis. + +In this tutorial, we will demonstrate how to: + +1. Parse the database. +2. Explore the data structure. +3. Visualize key insights using `dplyr` and `canvasXpress`. + +## 1. Loading Data + +### The Parsing Workflow + +In a real-world scenario, you would parse the full XML database +(downloaded from [DrugBank](https://go.drugbank.com/releases/latest)) +using +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md). + +``` r +library(dbparser) + +# Parse the full XML file (this creates a dvobject) +# drugbank_db <- parseDrugBank("drugbank_full_database.xml") +``` + +### Loading Sample Data + +For this vignette, we will load curated sample datasets included in the +package. These represent specific tables that would be found inside the +full `dvobject`. + +``` r +suppressPackageStartupMessages({ + library(tidyr) + library(dplyr) + library(tibble) + library(canvasXpress) + library(dbparser) +}) + +# Load sample tables representing parts of the parsed dvobject +drugs <- readRDS(system.file("drugs.RDS", package = "dbparser")) +drug_groups <- readRDS(system.file("drug_groups.RDS", package = "dbparser")) +drug_targets_actions <- readRDS(system.file("targets_actions.RDS", package = "dbparser")) +``` + +## 2. Analysis: The Drug Landscape + +What does the universe of approved drugs look like? Let’s analyze the +composition of the database by drug type (Small Molecule vs. Biotech). + +``` r +# Prepare data: Count drugs by type +type_stat <- drugs %>% + group_by(type) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + column_to_rownames("type") + +# Visualize +canvasXpress( + data = type_stat, + graphType = "Bar", + title = "Composition of DrugBank: Drug Types", + showSampleNames = FALSE, + legendPosition = "right" +) +``` + +## 3. Analysis: Approval Status + +Drugs are categorized into groups such as “approved”, “investigational”, +or “experimental”. How does the complexity (Biotech vs. Small Molecule) +differ across these groups? + +``` r +# Prepare data: Cross-tabulate Type vs Group +group_stat <- drugs %>% + full_join(drug_groups, by = "drugbank_id") %>% + group_by(type, group) %>% + summarise(count = n(), .groups = 'drop') %>% + pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% + column_to_rownames("type") + +# Visualize with a Stacked Bar Chart +canvasXpress( + data = group_stat, + graphType = "Stacked", + graphOrientation = "horizontal", + title = "Drug Types by Approval Status", + xAxisTitle = "Number of Drugs", + legendPosition = "bottom", + xAxis2Show = FALSE +) +``` + +## 4. Analysis: Molecular Mechanisms + +One of DrugBank’s most valuable features is the detailed information on +how drugs interact with their targets (Proteins, Enzymes, etc.). Are +drugs mostly inhibitors, agonists, or antagonists? + +``` r +# Prepare data: Top 10 most common Mechanisms of Action +targetActionCounts <- drug_targets_actions %>% + group_by(action) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + slice_head(n = 10) %>% + column_to_rownames("action") + +# Visualize +canvasXpress( + data = targetActionCounts, + graphType = "Bar", + graphOrientation = "vertical", + colorBy = "Count", + title = "Top 10 Mechanisms of Action", + xAxisTitle = "Number of Interactions", + showSampleNames = FALSE, + legendPosition = "none" +) +``` + +## 5. Next Steps: Integrated Pharmacovigilance + +Now that you have mastered the mechanistic data in DrugBank, you can +combine it with real-world data! + +`dbparser` now supports **OnSIDES** (Adverse Events) and **TWOSIDES** +(Drug-Drug Interactions). + +Check out the **[Integrated Pharmacovigilance +Vignette](https://docs.ropensci.org/dbparser/articles/integrated_pharmacovigilance.md)** +to learn how to merge these databases to perform polypharmacy risk +analysis. diff --git a/docs/articles/dbparser_2_2.html b/docs/articles/dbparser_2_2.html new file mode 100644 index 0000000..d5b0a83 --- /dev/null +++ b/docs/articles/dbparser_2_2.html @@ -0,0 +1,174 @@ + + + + + + + +Introducing dbparser 2.2.0 • dbparser + + + + + + + + + + + + + Skip to contents + + +
    + + + + +
    +
    +

    Introducing dbparser 2.2.0

    + + + Source: vignettes/dbparser_2_2.Rmd +
    dbparser_2_2.Rmd
    +
    + + + +

    Data in computational pharmacology is often siloed. We have databases +that tell us what a drug is (DrugBank), databases that tell us +what side effects it causes (OnSIDES), and databases that tell +us how it interacts with other drugs (TWOSIDES).

    +

    Connecting these silos has historically been a painful process of +manual mapping and ad-hoc scripting. Today, we are releasing +dbparser 2.2.0 to solve this problem once and for all.

    +
    +

    The “Hub and Spoke” Architecture +

    +

    Version 2.2.0 moves beyond simple XML parsing. We have re-engineered +the package around a “Hub and Spoke” integration model:

    +
      +
    • +The Hub: DrugBank serves as the anchor, providing +the stable molecular definitions.
      • +
    • +The Spokes: OnSIDES and TWOSIDES provide the +phenotypic and clinical layers.
      • +
    +

    We introduced specific functions to bridge these worlds. The new +merge_drugbank_onsides() and +merge_drugbank_twosides() functions don’t just combine +lists; they perform intelligent “double joins” and ID mapping (using +RxNorm CUIs) to ensure that your molecular data is correctly linked to +clinical outcomes.

    +
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    Pipeline-Ready Pharmacovigilance +

    +

    One of our main design goals was usability. The new merge functions +are “chainable,” meaning they integrate seamlessly with the +tidyverse. You can now build a massive, multi-domain +pharmacovigilance dataset in three lines of R code:

    +
    +library(dbparser)
+library(dplyr)
+
+final_db <- parseDrugBank("data/drugbank.xml") %>%
+  merge_drugbank_onsides(parseOnSIDES("data/onsides/")) %>%
+  merge_drugbank_twosides(parseTWOSIDES("data/twosides.csv.gz"))
    +

    The result is a unified dvobject (DrugVerse Object) that +contains mechanistic data, label data, and interaction data, all +enriched with common identifiers.

    +
    +
    +

    New Tools for Reproducibility +

    +

    To support developers and educators, we also exposed our internal +subsetting engines (subset_drugbank_dvobject and +subset_onsides_dvobject). These schema-aware functions +allow you to slice massive databases into consistent, shareable +micro-datasets—perfect for creating unit tests or teaching +materials.

    +
    +
    +

    A Scientific Case Study +

    +

    To demonstrate the power of this new workflow, we included a +comprehensive new vignette: Integrated Pharmacovigilance

    +

    In this tutorial, we perform a live analysis of +Leuprolide (a hormone therapy) and +Calcitriol (Vitamin D). We define their individual side +effect profiles using OnSIDES, and then use the new TWOSIDES integration +to quantify the specific risks—such as Anaemia—that arise when these two +drugs are prescribed together.

    +
    +
    +

    Availability +

    +

    dbparser 2.2.0 is available now. You can install it from +GitHub to get the latest features immediately, in case it is not +available on CRAN yet.

    +
    +devtools::install_github("ropensci/dbparser")
    +

    We look forward to seeing what the community builds with these new +capabilities!

    +
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    + + + + +
    + + + + + + + diff --git a/docs/articles/dbparser_2_2.md b/docs/articles/dbparser_2_2.md new file mode 100644 index 0000000..b3eec69 --- /dev/null +++ b/docs/articles/dbparser_2_2.md @@ -0,0 +1,81 @@ +# Introducing dbparser 2.2.0 + +Data in computational pharmacology is often siloed. We have databases +that tell us *what* a drug is (DrugBank), databases that tell us *what +side effects* it causes (OnSIDES), and databases that tell us *how it +interacts* with other drugs (TWOSIDES). + +Connecting these silos has historically been a painful process of manual +mapping and ad-hoc scripting. Today, we are releasing `dbparser` 2.2.0 +to solve this problem once and for all. + +#### The “Hub and Spoke” Architecture + +Version 2.2.0 moves beyond simple XML parsing. We have re-engineered the +package around a “Hub and Spoke” integration model: + +- **The Hub:** DrugBank serves as the anchor, providing the stable + molecular definitions. +- **The Spokes:** OnSIDES and TWOSIDES provide the phenotypic and + clinical layers. + +We introduced specific functions to bridge these worlds. The new +[`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md) +and +[`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md) +functions don’t just combine lists; they perform intelligent “double +joins” and ID mapping (using RxNorm CUIs) to ensure that your molecular +data is correctly linked to clinical outcomes. + +#### Pipeline-Ready Pharmacovigilance + +One of our main design goals was usability. The new merge functions are +“chainable,” meaning they integrate seamlessly with the `tidyverse`. You +can now build a massive, multi-domain pharmacovigilance dataset in three +lines of R code: + +``` r +library(dbparser) +library(dplyr) + +final_db <- parseDrugBank("data/drugbank.xml") %>% + merge_drugbank_onsides(parseOnSIDES("data/onsides/")) %>% + merge_drugbank_twosides(parseTWOSIDES("data/twosides.csv.gz")) +``` + +The result is a unified `dvobject` (DrugVerse Object) that contains +mechanistic data, label data, and interaction data, all enriched with +common identifiers. + +#### New Tools for Reproducibility + +To support developers and educators, we also exposed our internal +subsetting engines (`subset_drugbank_dvobject` and +`subset_onsides_dvobject`). These schema-aware functions allow you to +slice massive databases into consistent, shareable +micro-datasets—perfect for creating unit tests or teaching materials. + +#### A Scientific Case Study + +To demonstrate the power of this new workflow, we included a +comprehensive new vignette: **[Integrated +Pharmacovigilance](https://docs.ropensci.org/dbparser/articles/drugbank_nside.md)** + +In this tutorial, we perform a live analysis of **Leuprolide** (a +hormone therapy) and **Calcitriol** (Vitamin D). We define their +individual side effect profiles using OnSIDES, and then use the new +TWOSIDES integration to quantify the specific risks—such as Anaemia—that +arise when these two drugs are prescribed together. + +#### Availability + +`dbparser` 2.2.0 is available now. You can install it from GitHub to get +the latest features immediately, in case it is not available on CRAN +yet. + +``` r +devtools::install_github("ropensci/dbparser") +``` + +We look forward to seeing what the community builds with these new +capabilities! diff --git a/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.css b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.css new file mode 100644 index 0000000..e3e10e3 --- /dev/null +++ b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.css @@ -0,0 +1,7655 @@ +@charset "UTF-8"; + +/* + * Favorite Colors + * rgb(51, 122, 183) - #337ab7 + * rgb(76, 159, 224) - #4c9fe0 + * rgb(83, 105, 255) - #5369ff + */ + +:root { + /* Colors */ + --cx-color-red: rgb(255, 0, 0); + --cx-color-blue: rgb(0, 0, 255); + --cx-color-green: rgb(0, 255, 0); + --cx-color-yellow: rgb(255, 255, 0); + --cx-color-orange: rgb(255, 165, 0); + --cx-color-purple: rgb(128, 0, 128); + --cx-color-white: rgb(255, 255, 255); + 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grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemCombo { + border-top: var(--cx-border); +} + +.customizerRightItemComboNB { + display: grid; + grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemComboLeft { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboBottomRight { + grid-area: 2 / 2 / 3 / 3; + display: flex; + align-items: center; + padding-left: 15px; + padding-bottom: 2px; +} + +/* + * CanvasXpress Customizer Right Item Header + */ + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + color: var(--cx-font-color); + padding-left: 5px; +} + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + background: var(--cx-background-hover-color); +} + +.customizerRightItemHeader { + border-bottom: var(--cx-border) !important; +} + +.customizerRightItemHeaderNB { + border-bottom: none !important; +} + +.customizerRightItemHeaderTop { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemHeaderBottom { + grid-area: 2 / 1 / 3 / 2; + display: flex; + align-items: center; + padding-left: 10px; + overflow: auto; +} + +.customizerRightItemHeaderMain { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Sub Header + */ + +.customizerRightItemSubHeader { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemSubHeader { + background: var(--cx-background-hover-color); +} + +.customizerRightItemSubHeaderRow { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemSubHeaderRaw { + display: flex; + align-items: center; + border-radius: 5px; +} + +.customizerRightItemSubHeaderRaw { + border: var(--cx-border) !important; + background-color: var(--cx-background-hover-color); +} + +/* + * CanvasXpress Customizer Right Item Launcher + */ + +.customizerRightItemLauncher { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemLauncher { + border-top: var(--cx-border) !important; +} + +.customizerRightItemLauncherNB { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemLauncher:hover, +.customizerRightItemLauncherNB:hover { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemLauncherLeft { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + padding-left: 5px; +} + +/* + * CanvasXpress Customizer Right Item Input + */ + +.customizerRightItemInput { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: repeat(2, 1fr); + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemInputTopLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemInputTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; +} + +.customizerRightItemInputBottom { + grid-area: 2 / 1 / 3 / 3; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Cols + */ + +.customizerRightItemFullCol { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemHalfCol { + display: grid; + grid-template-columns: repeat(2, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemThirdCol { + display: grid; + grid-template-columns: repeat(3, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFourthCol { + display: grid; + grid-template-columns: repeat(4, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFifthCol { + display: grid; + grid-template-columns: repeat(5, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemSixthCol { + display: grid; + grid-template-columns: repeat(6, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemCol1 { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol2 { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol3 { + grid-area: 1 / 3 / 2 / 4; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol4 { + grid-area: 1 / 4 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol5 { + grid-area: 1 / 5 / 2 / 6; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol6 { + grid-area: 1 / 6 / 2 / 7; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemColMid { + grid-area: 1 / 3 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; + border-radius: 5px; +} + +.customizerRightItemColMid { + border: var(--cx-border) !important; +} + +.customizerRightItemSelect>select:hover, +.customizerRightItemTextArea>svg:hover, +.customizerRightItemTextArea>textarea:hover, +.customizerContainerRaw>svg:hover, +.customizerRightItemCol1>svg:hover, +.customizerRightItemCol2>svg:hover, +.customizerRightItemCol3>svg:hover, +.customizerRightItemCol4>svg:hover, +.customizerRightItemCol5>svg:hover, +.customizerRightItemCol6>svg:hover, +.customizerRightItem:hover { + background-color: var(--cx-background-hover-color); +} + +/* + * Other Customizer classes + */ + +.customizerContainer { + height: fit-content; + border-radius: 5px; + margin: 10px; + float: left; +} + +.customizerWrangling { + height: 102px; + margin: 0px 0px 10px 10px; + border-radius: 5px; + overflow-y: auto; + overflow-x: hidden; +} + +.customizerNumeric, +.customizerString, +.customizerUnique, +.customizerWrangling, +.customizerContainer { + border: var(--cx-border) !important; +} + +.customizerWrangling:hover { + border: 1px dashed var(--cx-color-red) !important; +} + +.customizerContainerRaw { + border: none !important; + float: left; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerMask { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + position: absolute; + left: 0px; + top: 0px; + margin: 0px !important; + width: 100%; + height: 20px; +} + +.customizerNumeric, +.customizerString, +.customizerUnique { + border-radius: 5px; + cursor: move; + margin: 3px; + padding: 3px; + word-wrap: normal; + display: inline-block; + text-align: start; + max-width: 150px; + overflow: hidden; + position: relative; +} + +.customizerNumeric { + color: var(--cx-font-color); + background-color: var(--cx-color-transparent); +} + +.customizerString { + color: var(--cx-color-green); + background-color: var(--cx-color-transparent); +} + +.customizerUnique { + color: var(--cx-color-blue); + background-color: var(--cx-color-transparent); +} +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + border: none; + cursor: move; + color: var(--cx-font-color); + margin: 0; + padding: 0 0 0 3px; + width: 350px; + white-space: nowrap; + display: inline-block; + text-align: start; + overflow: hidden; + position: relative; +} + +.customizerListNumeric { + color: var(--cx-font-color); +} + +.customizerListString { + color: var(--cx-color-green); +} + +.customizerListUnique { + color: var(--cx-color-blue); +} + +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + background-color: var(--cx-color-transparent); +} + +.customizerListNumeric:hover, +.customizerListString:hover, +.customizerListUnique:hover { + background: var(--cx-background-hover-color); +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + font: normal 10px courier; +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + color: var(--cx-background-color); +} + +.customizerListNumeric:before { + content: "\00a0#\00a0\00a0"; +} + +.customizerListString:before { + content: "Abc\00a0"; +} + +.customizerListUnique:before { + content: "Unq\00a0"; +} + +.customizerMask::selection, +.customizerNumeric::selection, +.customizerString::selection, +.customizerUnique::selection, +.customizerListNumeric::selection, +.customizerListString::selection, +.customizerListUnique::selection { + background: var(--cx-color-transparent); + color: var(--cx-color-black); + padding: 0; +} + +/* + * Search Customizer + */ + +input.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + height: 40px; + border-radius: 4px; + float: left; + clear: left; +} + +select.customizerSearch, +input.customizerSearch { + border: var(--cx-border); +} + +input.customizerSearch[type="color"] { + padding: 0; + overflow: hidden; +} + +input.customizerSearch:not([type="color"]) { + padding: 5px; +} + +select.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + padding-left: 3px; + border-radius: 4px; + float: left; + clear: left; +} + +span.customizerSearch { + color: var(--cx-font-color); + font: inherit; + line-height: 20px; + list-style: none; + position: relative; + margin: 5px 5px 0 15px; + float: left; + clear: left; +} + +span.customizerSearchSelect, +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + font: inherit; + line-height: 28px; + list-style: none; + position: relative; + height: 28px; + margin-top: 5px; + float: left; + clear: left; + left: 15px; +} + +span.customizerSearchSelect { + color: var(--cx-font-color); +} + +span.customizerSearchDescription, +span.customizerSearchCategory { + overflow: hidden; + text-overflow: ellipsis; + white-space: nowrap; +} + +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + color: var(--cx-background-color); +} + +span.customizerSearchSelect:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Select property ("; +} + +span.customizerSearchSelect:after { + color: var(--cx-font-color); + font-weight: bold; + content: ")"; +} + +span.customizerSearchDescription:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Description [ "; +} + +span.customizerSearchCategory:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Category [ "; +} + +span.customizerSearchDescription:after, +span.customizerSearchCategory:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +span.customizerSearchCurrent:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Current Value [ "; +} + +span.customizerSearchCurrent:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +/* + * Password + */ + +div.CanvasXpressPassword { + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: normal 16px arial, tahoma, sans-serif; + margin: 2px 3px; + overflow: hidden; + padding: 1px 12px; + width: 200px; + height: 185px; + white-space: nowrap; + position: relative; + text-align: left; +} + +img.CanvasXpressPassword, +svg.CanvasXpressPassword { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgb(0 0 0 / 0%) !important; + box-sizing: border-box; + cursor: default; + float: right; + margin: 5px 0px 0px 0px !important; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressPasswordContainer { + box-sizing: border-box; + border-radius: 0px 0px 5px 5px; + color: var(--cx-font-color); + display: block; + left: 0px; + line-height: 100%; + position: relative; + top: 15px; + margin-top: 5px; + -ms-user-select: none; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +span.CanvasXpressPassword { + margin-bottom: 5px; + margin-left: 5px; + float: left; +} + +input.CanvasXpressPassword { + float: left; + margin-bottom: 5px; + padding: 5px; + border-radius: 5px; + border: 1px solid rgb(170, 170, 170); + width: 170px; +} + +/* + * CanvasXpressDrag + */ + +div.CanvasXpressDrag { + opacity: 0.75; + box-sizing: border-box; + filter: alpha(opacity=75); + background-color: rgba(255, 255, 255, 0.95); + position: absolute; +} + +div.CanvasXpressDragLayout { + opacity: 0.65; + box-sizing: border-box; + filter: alpha(opacity=65); + background-color: rgba(51, 122, 183, 0.65); + position: absolute; +} + +/* + * Tooltip + */ + +div.CanvasXpressTooltip { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; +} + +div.CanvasXpressTooltipInfo { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + max-height: 800px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +/*****************************************************/ +/* Generators */ +/* A collection of Tooltips/Speech Bubbles */ +/* https://css-generators.com/tooltip-speech-bubble/ */ +/*****************************************************/ + +div.CanvasXpressTooltipInfoNone, +div.CanvasXpressTooltipInfoBottom, +div.CanvasXpressTooltipInfoTop, +div.CanvasXpressTooltipInfoLeft, +div.CanvasXpressTooltipInfoRight { + color: var(--cx-font-color); + font: var(--cx-font); + max-height: 800px; + padding: 10px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressTooltipInfoBottom { + border-radius: var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) / + var(--cx-callout-radius); + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 100%, + 50% calc(100% + var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 100% + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + var(--cx-callout-radius) max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / 0 0 + var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoBottom:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)), + 50% + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / 0 0 var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoTop { + border-radius: min( + var(--cx-callout-radius), + 50% - var(--cx-callout-size) * tan(45deg) + ) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) / var(--cx-callout-radius); + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 0, + 50% calc(-1 * var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / var(--cx-callout-size) + 0 0 0; +} + +div.CanvasXpressTooltipInfoTop:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width), + 50% + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0/ 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) var(--cx-callout-radius) max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / var(--cx-callout-size) 0 0 0; +} + + +div.CanvasXpressTooltipInfoLeft { + border-radius: var(--cx-callout-radius) / + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)); + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + 0 min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(-1 * var(--cx-callout-size)) 50%, + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0/0 0 0 + var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoLeft::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + var(--cx-callout-border-width) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)) + 50%, + var(--cx-callout-border-width) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0/0 0 0 var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoRight { + border-radius: var(--cx-callout-radius) / var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius); + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + 100% min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(100% + var(--cx-callout-size)) 50%, + 100% max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) / + 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressTooltipInfoRight::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + calc(100% - var(--cx-callout-border-width)) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ) + 50%, + calc(100% - var(--cx-callout-border-width)) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) / 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +img.CanvasXpressMousePosition, +svg.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + margin: 0px !important; + padding: 0px !important; + position: relative; + left: -13px; + top: -13px; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +span.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + left: 4px; + top: -20px; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressCanvasResizerClose { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAkAAAAOCAYAAAD9lDaoAAAAcUlEQVR42mM8e/bsfwYCgBGkSE9PD6eCS5cuIRSxsrIy/P79Gy4J42MoAgGQBDIbRRFMNwzATMVQhGwNVjehm/T582cwfevWLfxu+vTpO8Pt29ew++7Hjx8MvLy8mIpgAKTg/38WOB+uiGCIE1JAXUUA5WZpcWW3WYkAAAAASUVORK5CYII=); +} + +div.CanvasXpressCanvasResizerloading1 { + box-sizing: border-box; + background-image: url(data:image/gif;base64,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); + background-position: 50% 50%; + background-repeat: no-repeat; +} + +/********** + * Motion * + **********/ + +div.CanvasXpressMotion { + color: var(--cx-font-color); + font: var(--cx-font); +} + +img.CanvasXpressMotion, +svg.CanvasXpressMotion { + margin: 0px !important; + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; +} + +div.CanvasXpressMotionContainer { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAF0lEQVR42mNkAAJGNOLChQv/cRNYdAAA0dgUqRX/AM0AAAAASUVORK5CYII=); + background-repeat: repeat-x; +} + +div.CanvasXpressMotionCurrent { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAAlUlEQVR42mNkgIIDBw78ZyACODg4MCLzGWGa7e3tidHPcPDgQRRDGEGaTc0tidIMA6dPHocbAjZAV9eQJAMuXz5PZQM0NA1IMuDG9QuoBqioqJBkwJ07d1ANkJRWJ8mA509vUtkAUVFFkgx4/fo+qgG8fHIkGfD50yMqGgAiQIaws4oTpfnn75eoSRnGoCgzUQIoNgAAbjRcEcsB8BEAAAAASUVORK5CYII=); + background-repeat: no-repeat; + float: left; + height: 14px; + position: relative; + width: 14px; + z-index: 1000002; +} + +div.CanvasXpressMotionRange { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAFklEQVR42mNkAAJGNMKxcdd/3AQWHQAD/g7xOirtNAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + float: left; + height: 14px; + left: 0px; + top: -1px; + position: relative; + z-index: 1000001; +} + +/********* +* Marker * +**********/ + +div.CanvasXpressMarker { + box-sizing: border-box; + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + cursor: move; + font: var(--cx-font); + height: 502px; + width: 286px; + left: 0px; + line-height: 100%; + position: absolute; + top: 0px; + padding: 2px; +} + +/************* + * Toolbar * + *************/ + +div.CanvasXpressToolbarTop { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarTopContainer { + border: var(--cx-border); + border-radius: 0 0 8px 8px; + border-top: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer { + border: var(--cx-border); + border: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopOverContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarTopContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarBottom { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarBottomContainer { + border: var(--cx-border); + border-radius: 8px 8px 0 0; + border-bottom: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarBottomRound { + border-radius: 50%; + overflow: hidden; +} + +div.CanvasXpressToolbarBottomRound, +div.CanvasXpressToolbarBottomStripe { + cursor: pointer; + float: left; +} + +div.CanvasXpressToolbarLeft { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarLeftContainer { + border: var(--cx-border); + border-radius: 0 8px 8px 0; + border-left: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarLeftContainer img.CanvasXpressToolbarLeftImage, +div.CanvasXpressToolbarLeftContainer svg.CanvasXpressToolbarLeftImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarRight { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarRightContainer { + border: var(--cx-border); + border-radius: 8px 0 0 8px; + border-right: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarRightFont { + padding: 5px; + cursor: pointer; +} + +/************* + * Tooltip * + *************/ +div.CanvasXpressAltTooltip { + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 5px; + box-shadow: 0 0 5px var(--cx-color-transparent); + color: var(--cx-font-color); + font: var(--cx-font); + font-size: var(--cx-font-size); + line-height: 100%; + padding: 5px; + position: absolute; + display: none; + text-wrap: nowrap; + z-index: 1000000; +} + +/****************** + * Data Table DOE * + ******************/ + +table.CanvasXpressDataTableDOE { + border-spacing: 0 !important; + font-size: var(--cx-font-size) !important; + padding: 0 !important; + border: none !important; +} + +th.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + font-weight: bold !important; + padding-left: 5px !important; + padding-right: 5px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +td.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + padding-left: 5px !important; + padding-right: 18px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +tr.CanvasXpressDataTableDOE { + font-size: var(--cx-font-size) !important; +} + +/****************/ +/* Data Table */ +/****************/ + +div.CanvasXpressDataTableUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,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'); + background-size: contain; + background-repeat: no-repeat; + position: relative; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableContainer, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal, +div.CanvasXpressDataTableMask { + box-sizing: border-box; + position: absolute; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal { + color: var(--cx-font-color); + background-color: var(--cx-background-widgets-color) +} + +div.CanvasXpressDataTable { + border: var(--cx-border); + border-radius: 5px; + clear: both; + overflow: hidden; +} + +div.CanvasXpressDataTableToolbar { + border-bottom: var(--cx-border); + border-radius: 5px 5px 0px 0px; + height: 36px; + left: 0px; + line-height: 100%; + top: 0px; +} + +div.CanvasXpressDataTableContainer { + border-radius: 0px 0px 5px 5px; + display: block; + left: 0px; + line-height: 100%; +} + +div.CanvasXpressDataTableVertical { + overflow-x: hidden; + overflow-y: auto; + right: 6px; + top: 2px; + width: 16px; +} + +div.CanvasXpressDataTableHorizontal { + bottom: 12px; + height: 16px; + left: 2px; + overflow-x: auto; + overflow-y: hidden; +} + +div.CanvasXpressDataTableMask { + border: 0px; + top: 0px; + overflow: hidden; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage, +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + background: var(--cx-color-transparent) !important; + border-radius: 5px; + padding: 2px; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px !important; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage { + border: var(--cx-border) !important; +} + +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + border: none !important; +} + +img.CanvasXpressDataTableToolbarImageLogo, +svg.CanvasXpressDataTableToolbarImageLogo { + border: none !important; + float: left; + margin: 5px 0px 0px 10px !important; +} + + +img.CanvasXpressDataTableVertical { + max-height: unset !important; + height: revert-layer !important; +} + +img.CanvasXpressDataTableHorizontal { + max-width: unset !important; +} + +table.CanvasXpressDataTable { + border: 0px; + border-spacing: 1px; + color: var(--cx-font-color); + left: 1px; + position: absolute; + opacity: 0.95; + table-layout: fixed; + top: 1px; +} + +th.CanvasXpressTableCellHead, +th.CanvasXpressTableCellHeadActive { + border-top: none; + border-bottom: var(--cx-border-transparent); + border-left: none; + border-right: var(--cx-border-transparent); + font-weight: normal; + opacity: 0.95; + padding: 2px; + vertical-align: middle; +} + +tr > th.CanvasXpressTableCell:last-child, +tr > th.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +th.CanvasXpressTableCellHead { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +th.CanvasXpressTableCellHeadActive { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHead, +a.CanvasXpressTableCellHeadActive { + cursor: pointer; + position: absolute; + right: 8px; + white-space: normal; + text-decoration: none; + font-style: normal; + width: 14px; +} + +a.CanvasXpressTableCellHead { + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHeadActive { + color: var(--cx-background-color); +} + +td.CanvasXpressTableCell, +td.CanvasXpressTableCellActive { + border-top: none !important; + border-bottom: var(--cx-border-transparent); + border-left: none !important; + border-right: var(--cx-border-transparent); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + padding: 2px !important; + vertical-align: middle; +} + +tr > td.CanvasXpressTableCell:last-child, +tr > td.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +div.CanvasXpressTableCell, +div.CanvasXpressTableCellLink { + box-sizing: border-box; + color: var(--cx-font-color); + margin: 2px 2px 1px 5px; + overflow: hidden; + position: relative; + text-align: left; + white-space: pre-wrap; + word-break: break-word; +} + +div.CanvasXpressTableCell:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressTableCellLink:hover { + background-color: var(--cx-background-hover-color); + text-decoration: underline var(--cx-border); + cursor: pointer; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell, +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + border-radius: 5px; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell { + /* border: var(--cx-border-transparent); */ +} + +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + /* border: var(--cx-border) */ +} + +/***************/ +/* Data Filter */ +/***************/ + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar, +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive, +select.CanvasXpressDataFilterContainerString { + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar { + box-sizing: border-box; + line-height: 100%; + margin: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterToolbar { + border: var(--cx-border) !important; + border-radius: 4px; + left: 0px; + opacity: 0.95; + top: 0px; +} + +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive { + left: 8px; + line-height: 100%; + position: relative; + top: 9px; + background-repeat: no-repeat; + background-position: -0px; +} + +select.CanvasXpressDataFilterContainerString { + background-color: var(--cx-background-widgets-color); + margin-left: 3px; + margin-bottom: 3px; +} + +div.CanvasXpressDataFilterContent { + box-sizing: border-box; + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 0px 0px 4px 4px; + border-top: 0px; + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); + overflow-y: auto; + overflow-x: hidden; + padding: 2px; +} + +input[type=checkbox].CanvasXpressCheckbox { + accent-color: var(--cx-background-accent-color); + border-radius: 5px; + height: 14px; + width: 14px; + margin: 2px; +} + +label.CanvasXpressCheckboxLabel { + width: 220px; + text-overflow: ellipsis; + white-space: nowrap; + overflow-x: hidden; + margin: 0 0 0 3px !important; +} + +div.CanvasXpressDataFilterContainer, +div.CanvasXpressDataFilterContainerMask, +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable { + box-sizing: border-box; +} + +div.CanvasXpressDataFilterContainer { + border: 0px; + left: 0px; + margin: 0px; + padding: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterContainerMask { + border: var(--cx-border); + margin: 5px; + overflow-x: hidden; + overflow-y: scroll; +} + +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected { + height: 20px; + padding: 1px 0px 0px 1px; + overflow: hidden; + white-space: nowrap; +} + +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressDataFilterContainerHoverable { + border: var(--cx-border); + border-radius: 5px; + margin: 2px; + margin-bottom: 4px; +} + +div.CanvasXpressDataFilterHead, +div.CanvasXpressDataFilterHeadActive { + border: var(--cx-border); + border-radius: 4px; + box-sizing: border-box; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 38px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + text-align: left; + vertical-align: middle; +} + +div.CanvasXpressDataFilterHeadActive { + background:var(--cx-background-hover-color); + border-bottom: var(--cx-border-transparent) !important; + border-radius: 4px 4px 0px 0px; +} + +div.CanvasXpressDataFilterContainerTicks { + display: flex; + justify-content: space-between; + padding: 0px 10px; + height: 18px; +} + +span.CanvasXpressDataFilterContainerTicks, +span.CanvasXpressDataFilterContainerTicksLong { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + line-height: 10px; + margin-bottom: 10px; +} + +span.CanvasXpressDataFilterContainerTicks { + height: 5px; +} + +span.CanvasXpressDataFilterContainerTicksLong { + height: 10px; +} + +img.CanvasXpressDataFilterToolbarImage, +svg.CanvasXpressDataFilterToolbarImage { + border: var(--cx-border) !important; + border-radius: 5px !important; + padding: 2px; +} + +img.CanvasXpressDataFilterToolbarImageNB, +svg.CanvasXpressDataFilterToolbarImageNB { + border: none !important; +} + +span.CanvasXpressDataFilterText { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASElEQVR42mNkoBAwUt2A/0AAlgACsg0A6QWZQ4whOA2AsgkagtcAYgwhaAAhQ4gyAJ8htHcBRWFAUSxQlA7AEuSmRFLBwBsAAMDpRxF7e4BAAAAAAElFTkSuQmCC); +} + +span.CanvasXpressDataFilterTextActive { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASUlEQVR42mNkoBAwjhqAMOA/EBCtCQiwGoAkjhOA7MFqADGGoGvGGga4DMGmGWcgohuCSzNOA5ANwacZrwFIhuBVM4gS0oAZAAD1oisRsByngAAAAABJRU5ErkJggg==); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow, +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + box-sizing: border-box; + margin: 5px; + overflow: hidden; +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow { + border: var(--cx-border); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + border: none; +} + +input.CanvasXpressDateFilterContainerInputLeft { + float: left; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +input.CanvasXpressDateFilterContainerInputRight { + float: right; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +/***************/ +/* Toggle */ +/***************/ + +div.CanvasXpressToggle { + border: none; + margin: 5px; + height: 18px; +} + +label.CanvasXpressToggle { + cursor: pointer; +} + +div.CanvasXpressToggleSwitch { + display: inline-block; + background: rgb(204, 204, 204); + border-radius: 16px; + width: 28px; + height: 18px; + position: relative; + vertical-align: middle; + transition: background 0.25s; +} + +div.CanvasXpressToggleSwitch:before, +div.CanvasXpressToggleSwitch:after { + content: ""; +} + +div.CanvasXpressToggleSwitch:before { + display: block; + background: linear-gradient(to bottom, rgb(255, 255, 255) 0%, rgb(238, 238, 238) 100%); + border-radius: 50%; + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.25); + width: 14px; + height: 14px; + position: absolute; + top: 2px; + left: 2px; + transition: left 0.25s; +} + +label.CanvasXpressToggle:hover div.CanvasXpressToggleSwitch:before { + background: linear-gradient(to bottom, rgb(255, 255, 255)0%, rgb(255, 255, 255)100%); + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.5); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch { + background: var(--cx-background-color); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch:before { + left: 12px; +} + +input.CanvasXpressToggle { + position: absolute; + visibility: hidden; +} + +span.CanvasXpressToggle { + margin-left: 5px; + margin-right: 5px; + position: relative; +} + +/****************/ +/* Range Slider */ +/****************/ + +div.CanvasXpressRangeSliderContainer { + border: none; + margin: auto; + height: 110px; +} + +div.CanvasXpressRangeSliderContainerTop { + height: 18px; + margin: 5px; + position: relative; + display: flex; +} + +span.CanvasXpressRangeSliderContainerTop { + border: none; +} + +div.CanvasXpressRangeSliderContainerBottom { + height: 80px; + position: relative; +} + +div.CanvasXpressRangeSliderInput { + position: relative; + z-index: 10001; + height: 22px; + margin: 8px 0; +} + +input.CanvasXpressRangeSliderMin, +input.CanvasXpressRangeSliderMax { + color: var(--cx-background-color); + border: 1px solid var(--cx-background-widgets-color); + border-radius: 5px; + font: var(--cx-font); + margin-bottom: 2px; + line-height: 100%; + width: 60px; +} + +input.CanvasXpressRangeSliderMin { + float: left; + margin-left: 1px; +} + +input.CanvasXpressRangeSliderMax { + float: right; + margin-right: 1px; + text-align: right; +} + +div.CanvasXpressRangeSlider { + position: relative; + z-index: 10001; + height: 8px; + margin: 0 15px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderTrack { + position: absolute; + z-index: 10001; + left: 0; + right: 0; + top: 0; + bottom: 0; + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderRange { + background-color: var(--cx-background-color); + position: absolute; + z-index: 10002; + left: 0%; + right: 0%; + top: 0; + bottom: 0; + border-radius: 5px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + position: absolute; + z-index: 10003; + width: 18px; + height: 18px; + border-radius: 50%; + transition: box-shadow .3s ease-in-out; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + background-color: var(--cx-background-color); + box-shadow: 0 0 0 0 var(--cx-background-hover-color); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft { + left: 0%; + transform: translate(-15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + right: 0%; + transform: translate(15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft:hover, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight:hover { + box-shadow: 0 0 0 10px var(--cx-background-hover-color); +} + +input[type=range].customizerRightItemRangeSelect { + -webkit-appearance: none; + appearance: none; + width: 100%; + height: 8px; + border-radius: 5px; + background: var(--cx-color-extra-light-gray); + outline: none; + opacity: 1; +} + +input[type=range].customizerRightItemRangeSelect::-webkit-slider-thumb { + -webkit-appearance: none; + appearance: none; + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range].customizerRightItemRangeSelect::-moz-range-thumb { + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range] { + position: absolute; + pointer-events: none; + -webkit-appearance: none; + z-index: 10002; + height: 10px; + width: 100%; + opacity: 0; +} + +input[type=range]::-webkit-slider-thumb { + pointer-events: all; + width: 30px; + height: 30px; + border-radius: 0; + border: 0 none; + background-color: red; + -webkit-appearance: none; +} + +div.CanvasXpressRangeSliderTicks, +div.CanvasXpressRangeSliderTicksLog { + display: flex; + padding: 0px 10px; + height: 18px; + margin-top: 10px; +} + +div.CanvasXpressRangeSliderTicks { + justify-content: space-between; +} + +span.CanvasXpressRangeSliderTicksLong, +span.CanvasXpressRangeSliderTicks { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + margin-bottom: 10px; +} + +span.CanvasXpressRangeSliderTicksLong { + color: var(--cx-background-color); + height: 10px; + line-height: 35px; + font-size: small; +} + +span.CanvasXpressRangeSliderTicks { + height: 5px; + line-height: 10px; +} + +/** + * Input type number + */ + +input[type=number]::-webkit-inner-spin-button { + -webkit-appearance: none; +} + +/***************/ +/* Scrollbars */ +/***************/ + +/* All scrollbar buttons*/ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-button, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-button, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-button,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-button, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-button, +div.CanvasXpressDataExplorer::-webkit-scrollbar-button, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-button, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-button, +select.CanvasXpressConfigurator::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-button, +select.CanvasXpressSlider::-webkit-scrollbar-button, +div.cX-bin-name-container::-webkit-scrollbar-button { + width: 4px; + height: 4px; +} + +/* Tracks can be of two different colors */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track, +select.CanvasXpressConfigurator::-webkit-scrollbar-track, +select.CanvasXpressSlider::-webkit-scrollbar-track { + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track, +div.cX-bin-name-container::-webkit-scrollbar-track { + background-color: rgb(245, 245, 245); +} + +/* All tracks -hovers */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track:hover, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track:hover, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track:hover,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track:hover, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track:hover, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track:hover, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressConfigurator::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track:hover, +select.CanvasXpressSlider::-webkit-scrollbar-track:hover, +div.cX-bin-name-container::-webkit-scrollbar-track:hover { + background-color: var(--cx-background-hover-color); + border-radius: 8px; +} + +/* scrollbar background could be of two different colors but match the style tracks above */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar, +select.CanvasXpressConfigurator::-webkit-scrollbar, +select.CanvasXpressSlider::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar, +div.CanvasXpressDataTableVertical::-webkit-scrollbar, +div.CanvasXpressDataExplorer::-webkit-scrollbar, +div.CanvasXpressDataCustomizer::-webkit-scrollbar, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar, +div.cX-bin-name-container::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(245, 245, 245); +} + +/* All tracks thumbs */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-thumb, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-thumb, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-thumb,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-thumb, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-thumb, +div.CanvasXpressDataExplorer::-webkit-scrollbar-thumb, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressConfigurator::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-thumb, +select.CanvasXpressSlider::-webkit-scrollbar-thumb, +div.cX-bin-name-container::-webkit-scrollbar-thumb { + background-color: var(--cx-background-contrast-color); + border-radius: 8px; + border: none; +} + +div.CanvasXpressDataFilter::selection, +div.CanvasXpressDataFilterToolbar::selection { + background: var(--cx-color-transparent); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilterContainerItem::selection { + background: var(--cx-color-transparent); + color: var(--cx-background-color); +} + +/* + * Menu + */ + +div.CanvasXpressLink { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/gif;base64,R0lGODlh+gABAIcAAOLj4/Dw8P///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAP8ALAAAAAD6AAEAAAgfAAMIHEiwoMGBAAQcXMiwocOHECNKnEixosWLGCMGBAA7); + background-repeat: repeat-y; + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-font); + line-height: 100%; + margin: 0px; + opacity: 0.95; + padding: 0px; + position: absolute; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + position: relative; +} + +input.CanvasXpressTabMenuConfigurator { + display: none; +} + +input:not(:checked).CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + display: none; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + float: left; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + float: right; + width: 100%; + margin: 22 0 0 -100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + cursor: pointer; + -moz-user-select: none; + -ms-user-select: none; + -webkit-user-select: none; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + padding: 0.5px; + border: 1px solid rgb(238, 238, 238); + border-radius: 4px; + background: rgb(255, 255, 255) +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + margin: 0; + padding: 0.5px; + overflow: hidden; + font: var(--cx-font); + color: var(--cx-font-color); + line-height: 100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + display: block; + padding: 5px; + border: 1px solid rgb(238, 238, 238); + border-bottom: none; + border-top-left-radius: 4px; + border-top-right-radius: 4px; + background: rgb(255, 255, 255) +} + +input:first-child.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + padding-left: 0; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 1; +} + +input:checked.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 2; +} + +div.CanvasXpressMenu { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 100%; + margin: 0px; + padding: 0px; + position: absolute; + opacity: 0.95; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +ul.CanvasXpressList { + background: transparent; + border: 0px none; + cursor: default; + list-style: none; + margin: 0px; + overflow: auto; + padding: 2px !important; + height: calc(100% - 100px); +} + +li.CanvasXpressListItemSep { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + height: 100%; + line-height: 1px; + list-style: none; + margin: 0px; + padding: 1px; + /* width: 100%; */ + white-space: nowrap; +} + +input.CanvasXpressListItem { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 100%; + list-style: none; + margin: 0px; + padding: 1px; + white-space: nowrap; +} + +input[type=file] { + display: block; +} + +div.CanvasXpressListItem { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; +} + +li.CanvasXpressListItem { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemActive { + background: rgba(83, 105, 255, 0.1); + border-color: rgb(83, 105, 255); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemScrollTop { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAARUlEQVR42mNkQAMXL178z0Ah0NfXZ0Tmo3BAFkhLS+M1IDw8kmHlyuV41Tx9+hTFIjiDWAtggBSLGMmxgFSLGKkRB4QAAILWJXgE49MrAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollTopActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAbUlEQVR42mNkQAOHb/38z0AhsFVjZ0Tmo3BAFmjIsOHULMLJwKDs1sFwd1cFw5vvuC258eQXikWMyBYoSOC2QIYXYgEMgCx68hm3RQ9eICxihFkgzI/bAk0xVAuQLbr+CrdFbz9CLGKkRhwQAgBYqyubRxy5uAAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottom { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAASUlEQVR42mO8ePHifwYaA0YQAbJIWloar8Lw8EgMsZUrl+PV8/TpUwZ9fX1GRpgAqRYRawHcJ6RaRIoFGJbALCIcyvgBsgUgAACiryV42XltywAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottomActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAcklEQVR42mM8fOvnfwYaA0YQAbJImJ8NpyJNMQYGZbcODPG7uyoYrr/Cbfjbj78YbNXYGRlhAiCLFCRwWyTDi2oRyIInn3Fb8OAFxAK4T5At0pDBbZEIJ8QikAVvvuO24MYThAUYlsAsIjPo4QDZAhAAAK/AK5vjVTSgAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollSearch { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 1px; + width: 100%; +} + +input.CanvasXpressListItemScrollSearch { + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 3px; + outline-style: none; + outline-width: 0px; + padding-left: 5px; + width: 93%; +} + +a.CanvasXpressListItemA { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAActive { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrow { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrowActive { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +img.CanvasXpressListIcon, +svg.CanvasXpressListIcon { + background-position: center; + border: 0px none !important; + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + height: 24px; + line-height: 24px; + list-style: none; + left: 3px; + margin: 0px !important; + padding: 0px; + position: absolute; + top: 3px; + vertical-align: top; + width: 24px; + white-space: nowrap; + background: rgba(0, 0, 0, 0) !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; +} + +span.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin-right: 10px; + white-space: nowrap; +} + +input.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + white-space: nowrap; +} + +span.CanvasXpressListItemTextShort { + color: var(--cx-font-color); + cursor: pointer; + float: right; + font: var(--cx-small-font-italic); + line-height: 24px; + list-style: none; + margin-left: 10px; + white-space: nowrap; +} + +span.CanvasXpressListItemTextSep { + background-color: rgb(224, 224, 224); + border-bottom: 1px solid; + border-bottom-color: rgb(255, 255, 255); + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + line-height: 1px; + list-style: none; + margin: 2px 3px; + overflow: hidden; + white-space: nowrap; +} + +table.CanvasXpressListItemTable { + border: collapse; + line-height: 20px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + padding-left: 3px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +img.CanvasXpressToolbarHelp, +svg.CanvasXpressToolbarHelp { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + float: right; + margin: 0px 0px 0px 2px !important; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressToolbarHelp { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border-radius: 5px; + border: 1px solid rgb(83, 105, 255); + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +p.CanvasXpressToolbarHelp { + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + margin: 0px; + padding: 5px 5px 5px 20px; +} + +div.CanvasXpressForm { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + color: var(--cx-font-color); + cursor: move; + font: var(--cx-x-large-font); + margin: 8px; + padding: 8px; + position: absolute; + white-space: nowrap; +} + +input.CanvasXpressFormButton { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mP88OHDf0aSiGfPntGaAAAL8XAJa+SuYgAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 5px 5px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormButtonActive { + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mN89fnvf0aSiBvPf9GaAABVL3D5nF6uqAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 0px 0px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormText { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + padding-left: 3px; +} + +form.CanvasXpressFormForm { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + margin: 8px; + overflow: auto; + padding-left: 3px; +} + +div.CanvasXpressConfiguratorColor { + box-sizing: content-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-font); + color: rgb(34, 34, 34); + line-height: 18px; +} + +div.CanvasXpressConfiguratorColorMain { + box-sizing: content-box; + background-image: url(data:image/png;base64,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); + background-repeat: no-repeat; + box-sizing: content-box; + border: none; + font: var(--cx-font); + color:var(--cx-font-color); + float: left; + cursor: crosshair; +} + +div.CanvasXpressConfiguratorColorExtra { + box-sizing: content-box; + background-image: url(data:image/gif;base64,R0lGODlhDwAPAKEBAAAAAP///////////yH5BAEKAAIALAAAAAAPAA8AAAIklB8Qx53b4otSUWcvyiz4/4AeQJbmKY4p1HHapBlwPL/uVRsFADs=); + background-repeat: no-repeat; + border: none; + font: var(--cx-font); + color: var(--cx-font-color); + cursor: crosshair; + overflow: hidden; +} + +/* + * Slider + */ + +div.CanvasXpressSlider { + background: rgba(0, 0, 0, 0); + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 50%; + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSliderRemote { + background: rgba(0, 0, 0, 0); + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSlider:hover { + background: rgba(0, 0, 0, 0.4); +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSlider { + width: 20px; + height: 20px; + } +} + +div.CanvasXpressSliderLeft { + left: -50px; +} + +div.CanvasXpressSliderLeft img, +div.CanvasXpressSliderLeft svg { + margin: 5px 5px 3px 3px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderLeft { + left: -25px; + } + + div.CanvasXpressSliderLeft img, + div.CanvasXpressSliderLeft svg { + margin: -4px 0px 0px -2px; + } +} + +div.CanvasXpressSliderRight { + right: -50px; +} + +div.CanvasXpressSliderRight img, +div.CanvasXpressSliderRight svg { + margin: 5px 3px 3px 8px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderRight { + right: -25px; + } + + div.CanvasXpressSliderRight img, + div.CanvasXpressSliderRight svg { + margin: -4px -2px 0px 2px; + } +} + +div.CanvasXpressSliderDotsContainer { + top: 25%; +} + +div.CanvasXpressSliderDots { + width: 10px; + height: 10px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderDots { + width: 5px; + height: 5px; + margin-left: 1px; + margin-right: 1px; + } +} + +input.CanvasXpressSlider, +select.CanvasXpressSlider { + padding: 2px 3px 2px 2px; + cursor: default; + color: var(--cx-font-color); + border-left: none; + border-right: none; + border-top: none; + border-bottom: 1px solid rgb(83, 105, 255); + background: rgba(0, 0, 0, 0); + width: 100%; + max-Width: 100%; + line-height: 22px; + margin: 0; +} + +input.CanvasXpressSlider:focus, +select.CanvasXpressSlider:focus { + outline: 0; +} + + +/* +@media (max-width: 480px) { + img { + height : 16px; + width : 16px; + } +} +*/ + + +/* + * Parent Node + */ + +div.CanvasXpress-ParentNode { + /* + border: 1px solid 'rgba(0,0,0,0)' + margin: auto; + display: table; + padding: 0; + */ + -moz-transform: none; + -webkit-transform: none; + -o-transform: none; + -ms-transform: none; + transform: none; +} + +/* + * CanvasXpress Tab Panel + */ + +div.CanvasXpressTabPanel { + font: var(--cx-x-large-font); + float: left; + width: 100% +} + +/* Customizer */ + +div.CanvasXpressTabPanelCustomizer { + position: relative; + border-bottom: 1px solid rgb(238, 238, 238); + top: -10px; + overflow: hidden; +} + +div.CanvasXpressTabPanelRibbonSection { + width: fit-content; + position: relative; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + padding-left: 8px; + padding-top: 5px; + margin-top: 12px; + float: left; +} + +span.CanvasXpressTabPanelRibbonSection { + margin-left: -3px; + background-color: white; + position: absolute; + float: left; + top: -14px; + padding: 3px; +} + +div.CanvasXpressTabPanelRibbon { + float: left; + margin-right: 10px; +} + +span.CanvasXpressTabPanelRibbon { + color: var(--cx-font-color); + font: var(--cx-x-large-font); + line-height: 28px; + list-style: none; + white-space: nowrap; + position: relative; + height: 28px; +} + +div.CanvasXpressTabPanelRibbonContainer { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +svg.CanvasXpressTabPanelRibbon { + float: left; + border: 1px solid rgb(83, 105, 255); + margin-left: 5px; + margin-top: 5px; + padding: 2px; + border-radius: 5px; + background-color: rgb(255, 255, 255); +} + +svg.CanvasXpressTabPanelRibbon:hover { + background: rgba(83, 105, 255, 0.1) +} + +/* Header */ + +div.CanvasXpressTabPanelHeader { + font: var(--cx-x-large-font); + border-bottom: 2px solid rgb(83, 105, 255); + height: 38px; + width: 100%; + float: left; +} + +div.CanvasXpressTabPanelHeaderTab { + font: var(--cx-x-large-font); + margin-left: 20px; + margin-right: 20px; + float: left; +} + +input.CanvasXpressTabPanelHeader { + border-width: 1px 1px 0 1px; + border-color: rgb(83, 105, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +input.CanvasXpressTabPanelHeaderActive { + border-bottom-width: 2px; + border-left-color: rgb(83, 105, 255); + border-top-color: rgb(83, 105, 255); + border-right-color: rgb(83, 105, 255); + border-bottom-color: rgb(255, 255, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +/* Content */ + +div.CanvasXpressTabPanelContent { + display: block; + float: left; + width: 100%; + position: relative; +} + +/* Rows */ + +div.CanvasXpressRow { + clear: both; + display: flex; + flex-wrap: wrap; + float: left; + width: 100%; +} + +div.CanvasXpressRow:before, +div.CanvasXpressRow:after { + content: " "; + display: table; +} + +div.CanvasXpressRow:after { + clear: both; +} + +div.CanvasXpressRowColumnFull, +div.CanvasXpressRowColumnTwoThird, +div.CanvasXpressRowColumnThreeFourth, +div.CanvasXpressRowColumnFourFifth, +div.CanvasXpressRowColumnFiveSixth, +div.CanvasXpressRowColumnHalf, +div.CanvasXpressRowColumnThird, +div.CanvasXpressRowColumnFourth, +div.CanvasXpressRowColumnFifth, +div.CanvasXpressRowColumnSixth { + float: left; + /* + padding-left: 1rem; + padding-right: 1rem; + */ + -moz-box-sizing: border-box; + -webkit-box-sizing: border-box; + box-sizing: border-box; +} + +div.CanvasXpressRowColumnFull:hover, +div.CanvasXpressRowColumnTwoThird:hover, +div.CanvasXpressRowColumnThreeFourth:hover, +div.CanvasXpressRowColumnFourFifth:hover, +div.CanvasXpressRowColumnFiveSixth:hover, +div.CanvasXpressRowColumnHalf:hover, +div.CanvasXpressRowColumnThird:hover, +div.CanvasXpressRowColumnFourth:hover, +div.CanvasXpressRowColumnFifth:hover, +div.CanvasXpressRowColumnSixth:hover { + border: 1px dashed rgb(238, 238, 238); +} + +div.CanvasXpressRowColumnFull { + border: 1px dashed white; + width: 100%; +} + +div.CanvasXpressRowColumnFullActive { + border: 1px dashed rgb(83, 105, 255); + width: 100%; +} + +div.CanvasXpressRowColumnTwoThird { + border: 1px dashed white; + width: 66.7%; +} + +div.CanvasXpressRowColumnTwoThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 66.7%; +} + +div.CanvasXpressRowColumnThreeFourth { + border: 1px dashed white; + width: 75%; +} + +div.CanvasXpressRowColumnThreeFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 75%; +} + +div.CanvasXpressRowColumnFourFifth { + border: 1px dashed white; + width: 80%; +} + +div.CanvasXpressRowColumnFourFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 80%; +} + +div.CanvasXpressRowColumnFiveSixth { + border: 1px dashed white; + width: 83.4%; +} + +div.CanvasXpressRowColumnFiveSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 83.4%; +} + +div.CanvasXpressRowColumnHalf { + border: 1px dashed white; + width: 50%; +} + +div.CanvasXpressRowColumnHalfActive { + border: 1px dashed rgb(83, 105, 255); + width: 50%; +} + +div.CanvasXpressRowColumnThird { + border: 1px dashed white; + width: 33.3%; +} + +div.CanvasXpressRowColumnThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 33.3%; +} + +div.CanvasXpressRowColumnFourth { + border: 1px dashed white; + width: 25%; +} + +div.CanvasXpressRowColumnFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 25%; +} + +div.CanvasXpressRowColumnFifth { + border: 1px dashed white; + width: 20%; +} + +div.CanvasXpressRowColumnFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 20%; +} + +div.CanvasXpressRowColumnSixth { + border: 1px dashed white; + width: 16.6%; +} + +div.CanvasXpressRowColumnSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 16.6%; +} + +/* + * CanvasXpress + */ + +canvas.CanvasXpress { + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + user-select: none; + -ms-user-select: none; +} + +canvas.CanvasXpress:hover { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; +} + +canvas.CanvasXpressUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,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'); + background-size: contain; + background-repeat: no-repeat; +} + +canvas.CanvasXpress::selection { + background: rgba(0, 0, 0, 0); + color: rgb(0, 0, 0); +} + +div.CanvasXpressPlay { + background-color: rgba(0, 0, 0, 0.05); + background-image: url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAIAAAACACAYAAADDPmHLAAARtElEQVR42u2dB7gdRRXHT0AUMdIEARF5IBEpIh9GQIh4RSw0AwjYKIpUQQUpghUbICIWLIiU2OgoVQxFnijSFKWpFOGpFCUiLQpY0Pm92U0um5md2Tpz793/950vedvu7MzZmdNnigwfpihaWdFaisYSepGiZRN6nqJnK3qGoqnJPXMV/UfR44oeVDQnoT8pmkjoluTv/4V+wbo7a9CxvKIZijZStIGitRUt3tBvParoZkXXKfqFop8r+kvoDqiCQWSAZyrqKXqjos0VrRG4Pb9TdLGi2YrGFf0rcHsKYVAYgOn6dYrermgbRUuEbpAFjyg6V9Fpii4XvaxEjdgZ4MWKdkto+dCNKQiWhpMVnaTortCNsSFWBugpOkjRFhXbiHA3kdC9ogU86CFFTyl6MrnuWYoWUrSUaCERWlHmC5FTvX9xQSA0XqToC6KXiKgQEwPQljcr+qii6SXuR2pHKENAu0m0sPbnmtq2kqKXKVpH0fqihc5lSzznl4o+o+i8OjuuCmJhgM0UfVrRhgXuQWUbFy2AXaLotpbbvLqiN4gWRHuiVUtfXKPoY4oua7nNCyA0A7xE0bGKtvS8/gnR0+lZyb9zA7c/xdTkHXZI/l3U8z7e4QBFd4RqeCgGoIM+oeiDotU6F5jOT1T0PUV/D9RmXyytaCdFu4teNlxAbeQjOFzmyyStIQQD9BSdoGia4zqEJ6Z3OufyAO2sA6iuCLPYLFx9zSywp7QsKLbJAEjaRyra3/G7DDxC0icV/abNzmgQ64qe8WZ6vPuXFB0qLRmU2mKANUUbR9ZxXDcueln4dUvtahvriVYHe47rblT0DkW/bbpBbTAAghEGkTxd+m5FByr6YQvtiQHbKTpG0So51yDgYgA7q8mGNMkACys6SvTA2n4HU+mXFX1c0T+bfNEIsZiiT4leEhe2XMOSwIzBkvDfJhrRFAOgEzPlz8y5BifKzop+1VAbBgWvEK3dvDTnGvwLLAmP1/3jTTDAMqKl9zxr3vGiZ4ZR++ptYDbgS98755rrRZvG/1bnD9fNANjPsW7ZuLmVdW2AsaNo55FNXmLWfL1ov0YtqJMBVhXtE1/Ncv52RdtKC5LtgINIJoRhm53kTtEm6Lvr+LG6GIAvf1zsg/8z0YP/YF29NOTAG8m6P8NyHiboSQ0zQR0MwJrPANum/TMU7SoBzJwDDgxn3xG9LJjAcrCJVJQJqjIA0v6VYhf4sN8j2DSiwowAUA+/qeg9lvMIhq+RCtpBFQagceeIXdX7hqJ9ZciiaAOAMfqaon0s51kqtpeSH1kVBvi8aEeHCXz5ODa6wa8HjBN9upvlPFbFg8s+uAww755pOcea/07ppv26wYx7qphlAj60t0oJ9boMA+DYuVbMuirCIHpqJ/A1AwRD7Cwm7QAbC3kRhdTsogxAA4i5M3n10PNJzuhUvWaBini1mO0EeBFhAu8PsCgDEJxxgOF4Ke7rUBoYi4grNM3CXxTtUvdCEQboKfqJ5R7Wpc682y7o8zMMx5EHNhXPyCJfBkDfZ3oxTTs4dvbxfE6HeoGqbXIgEV7GMv2E6wG+DIBf/0OG41ijMAJ1Xr0wwIuIO91khWXMDnM9wIcBCN0mKjcbvUswx4bS+fNDg3gCtLJsUAkxhWRK54ac+zDAhWKO2y9tfOhQOxiLAw3HGbut8250MQAZO5cajuOKhLtCTP3owGOibQ5/DPD7MYKlgAIWphhD7DLWDKQ8BuAcRRBM6VoENYYI4ETg3Cv5P1PccaLj6h4N0JbYwJicYziOuvgq2015DICT51zD8XFFrw3wgki1NxqOPyA6oZRImqcCtCsmXCHmkHPG8nzTDXkMgKsx6+ZFx0ToCBG3b2PIFCSRvF/00jCqYGwYt+y4kpX8StMNNgboieamLBiAbQO9nIsBUuCkOkRGVz5gad7GcJxZezx70MYAJsmfr5/MllDpWr4MAAiQwF39ORk9GwVpaDfIgmNr1AhMDEBZljsM534k/mncTaAIA6S4R7QBixyFUYpNICz/TZljvD8xm08rV2NigM8q+rDhOCphyCxdGwMg+C3kuBdthgyc6wO2v02QlWxS/Y5Q9JH+A1kGWER0McRsQSYsga7EzqZhYwAEVdLLNnbcD6MQZEma1V8Dv0sboExOtj4BhasodzOvelmWAchj/7HhYUjXxwV+IRsDTEmIiJijkxfMw2OiZzncpgNV068gPiA61TwLlobZ6R9ZBvi2ol0yx/AoEfcfujJHHgOkwCJ2SEKumj2shfjNoynYVDOoVELeQLZczSxF707/6O88on2YGrNFGLEubR/6bcSPAVIwC6AF7ChuczdrJUEut4R+wQZwtqK3ZI5RzHI5SaKG+juHdKPZhoe8TcyBB22jCAOkwG+AfLCe49msicTfk6YeeqarEyyLpxuOM9aTPp7+zmNN3D9zIfo09fD+EfpNpBwDADQEpjzW/eUc1zL4h4sOtIi+zKsHCBnDVJ5dDgntm/Qe9nce8XzZwsvok1uEfosEZRkgBUsbKhDCkasy2a2il4VLXQ8dAGC/2TxzjEAeorvndd4Kiu4z3ByD9J+iKgOkIKyNXPytPa7FgYKg+IfQL18B71P0FcPxFyi6P+08hDxTUCfVMG8P/QYJ6mKAFKyDLHtrOq5DVUSdosTrY6E7oQQYw98bjpPcc3baeaZwb9YO15rZJupmAEAZ+veKXveXclyLhoSFdJYMntuZsczWNp4MH0877yrRSR39wKu0XeiW96EJBkhBsgW1ivcQzRR5IAYSOeKq0B1SAPRbNomX9s9IrWgPy4LbrBBRelTolvehSQZIQZgbauOmjutwrKBe4WiqqyJ5k8D8fWTmGFFUS9J5Y2IuN4L0f3HolvehDQZIQcwDgZarOq7D1Xx0QrVX8KoReHEvNBxfZUrOSXbaiom722QAgAkVuwjr/nMd1+JAw/xMMEqMbueVkjZmsSWdRxGHr2ZOzPV46bbRNgOkQF3CiLSrx2+xYQWqc4ylbhnT52SO7ccLmQo9YBf3KXXeJkIxQApi6tCnXZtaoCGcInrmeKC13nEDl/7amWPH0HnY+bNFBy4QvX1LTAjNAOlvUbGTULMVHdciZGE7wIbw7xbbaANjulXm2Jm8EBm/2TBvHCN7+zy1RcTAACmYSpGssae73M53JNddEKCd/WBM98wcu4LOM00NC4QORYCYGCAFW9SyhO7gcS2eVszKoWooMKbZZNFb6Dx8ACtkTsCxxwZqqA0xMkAKSrUx1a/ruA4P49dFWx4farmNjOkxmWOTvgAasmTmBO7TWS030IWYGQCQnUs9PyyKz3dcSxkdhMRvSXtqIxXGTsoce5jOw8GRLTXyLtHhYTEhdgZIwcfElnB44RZxXHu46K1x2gBq7KzMscfoPBMHskfv6a4ntoxBYYAU1FVgWdg85xpmgmVaag9jemr2YMcAzcGHAajzW2YH0jKwMkC3BNQLIo/YIWw/cS8BaFpHtNQu6xLQCYH1IBUCMf64vmoshNgRTmmxfVYhsFMDqwM1EDfyyx3XEV2EORkmeaTlNlrVwM4QVB5jol3BPoYgPK4YgkLtE2w1BJmqSnSm4HyQgYQez4C6TMFE4BJuN9v10IZhNQWbnEHO6lIBEAMD8FtUQidSyuUMQrZCx6fWfww5BlZnUOcO9oOvO5jBxsJHllGtW7xVhNUd3AWE5AMBmXi6XTx+i+WUgNGbW+8dN8juWixzbL8uJMwOkmVZuxGGpzqujX3vY8bSVDNpMiSM4oJ3mU6KTiuKBTEGhTJTEi6Gxc9ZmDkgcoNCu7Dw+UDuYTB9wsKpNoImcJ/roREgNywcdIkh/okhVN5knb8udIcUQG5iCOhSw9ypYVTb4Ev6vsQZ+p0HZ2qYLTmUOvS3hW59giaSQ5nu13BcR8IHHwhTaAx1EorCKzl01NLDGdCtPK6lxAol8SdCv3wFeKWHg2EvEIGQS6QOTO0qEEFRatb5n4Z+6RrgVSACUDQhu9sU0x/xbXNDv4VUKxGDKxQPnEummSPzK48Pw8aXhUrEDGORqFeLXuddRaJI3MAayt4DD4d+0RphKxI1bxOJYS0Th+ULN61PmTiWOTSgWITdOlGoTByYJTp0qB9YuBAY2o5jz8KHAZjqyNn3KRTJgDPwMaXA1wnUWgT7bKFIopDmbULtWyoWgcgkSbYJn1KxeDZf6HgOUzxTPVN+DDl7TaFUqdhBLRYNc27kuJ+s3dRNG1PWblMwuX+dxaLBMJaLR53ji7hRRgOly8WDYdowYkK0IefsgO0OAduGEYzt08oB2SRkU/jQIG0Zg8kW0y36bsy1e5pA5S1jQE8Gc9MomJTsF7SAQXDTNgHbplE9MVg2h2nbONyzrPPXBGhbLKht2zgQ28aRBGvcZDjOl47QSoDGoLlp60atG0fGuHUsuvu+yf+xZKVu2kGs4Vs3sPiZhN3SW8eCGDeP5mWI1WM9uyfA78cIon0pcT9mOFd68+gUtu3j8R4e5HF/h+bR2PbxgAAKEkWyPnTcpRuILp7cIRwQ/K4VnZ3cDxJRmaVzcxF9gylYZw81HCewAE1h1LZnjQVM/ej8qxvOEdF9mOsBvgyAZw0z6jTDueMV7RO6J0YU7G1kSuLlq8d348xVKBJP1xNdVNJ0D564M0P3xoiBWAdToA6qMGq6Vzhb0YBKU/g4IGQMdfHW0L0yIlhLtHpnSlmbDPf2fVBRBiBqCIubyTXMtAMTDNO+ezGCJJarxbwcs0wjmD/p+7AyMfVEkyJ1mriPcumbFWlAh0Iguge7zAzDOWbh9UUL5t4om1RBUsEZlvuRBaioPQxRtTEBNQ9H146Gc6z7yGFnFXqiVEurMhWWSEFY9R7S2ebrAuN0ovTF8mWAIejgsg8uCziSiOGZlvOoKNjtOyaoBsaIMjM2VRuHHVHbpWbcqpm1GCJQN6ZbzjMT7FW2cR0mP7ITxP7l4/rtSQVDXB2p1WSdXik6kdQEZIKdRZsmO/gD0/t3xbzmA4Q96hPOqfIjdRVXoGLWuKLVLOfRDlgqOhXRD0srOk/M0j64U/SXf2/VH6qzugalZi4ROxNgJyCcrDMW5QMjD7EW0yznGXxcvBN1/Fjd9XWYCfA925YDdFXq6XZmYzOY7pGbbEWpmPYZ/MpffoomCiwhExBCPj3nGhxImCtHLWLXBoRp4ivyqrMi8BGXUWnNz6KpEmu8EKVUtsm5hqoVO0kXT4A/n75aPecaVD0qlNbudm+yyCIqDD7pA3N+B/WQ/DUKN4zabICLncJUbE+7sOUabCjMDMRiNKJKt1FmFbPxyZJfbJEYQ6yKP2ihPTGAAE6sd2M51yAvof8XNu8WQVt1dnEgnSbuBNNx0TPGDS21q20w3TPwPcd1ePXY4qWQY6cM2qy0jSuZ0LL9Hb/LtIcOTKXtUGlodYN0LbaRmenx7iyJhHK14lENUWu/J9q8Oc1xHZ1BHjtfTMis5CogS5eljboLrr7GTkI9//E2Gxhqtw0EIPL0UQVdFbsAue7ox2T/hK5U4gKVOagsvrssmJ9vAiZyIq2Y8VqvNxx6vx1mAUKYfNPO6aCLRAtGxLzHUriRzaTJpt4heZdFPe8LvY1McAZIQRQRKpFrM4Z+oDaOi86FxwTddpEn9HYqq1GDryfumkT9IJ4P1feyAvc0glgYIAVCEnX6ppe4FwsZuYx0LksGiaR17XdAWRU0GBJUYVLK0ZTZ8JEsXRj9/BL3NoLYGCBFT7Q6uGXFNrJEYGOYEG0/xxvJdq3IERhWUhc1cgjGGNZvgi7xxuHXGBOdh7hYgd/MAmGWZQuDznjrPelArAyQgs7HeYRBZPmKz2obFGTCAIbwelfFZzWG2BkgBdXL2MSBqqW4lJeo9rjGQBFGXLlU5ySJJvoydIPCAP3AoLSJ6CJICGCucu9NA2sdgij1FYmMGqiQ+EFkgCwodb+xaMGMuHgEtcUrPdEOtllBwCQ5BoGTXTfuD90BVTAMDGB6p5VF+x+IUhoTXTt42YQQ8lDZ2C0kdVDheKF4IqolQuKchCiaOSFakKScPjtvDVWU8/8BFWavcIiHLzgAAAAASUVORK5CYII='); + background-position-x: 50%; + background-position-y: center; + background-size: 25%; + background-repeat: no-repeat; + position: absolute; +} + +div.CanvasXpressPlay:hover { + background-color: rgba(0, 0, 0, 0); +} + +div.CanvasXpressContainer { + box-sizing: border-box; + position: relative; + float: left; +} + +div.CanvasXpressWrapper { + box-sizing: border-box; + position: relative; + float: left; + line-height: 100%; +} + +/* + * full-screen-warning-container + */ + +#full-screen-warning-container { + background-color: transparent !important; + opacity: 0.4 !important; +} + +#full-screen-warning-container[fade-warning-out] { + transition-property: opacity !important; + transition-duration: 1ms !important; + opacity: 0.0 !important; +} + +#full-screen-warning-message { + padding: 15px !important; +} + +.full-screen-description { + font-size: 100% !important; +} + +#full-screen-domain-text { + font-size: 100% !important; + font-weight: bold !important; +} + +.full-screen-approval-button, +#full-screen-remember-decision { + font-size: 100% !important; +} + +@media (min-width: 300px) { + div.cX-bin { + transform: scale(0.5); + } +} + +@media (min-width: 450px) { + div.cX-bin { + transform: scale(0.75); + } +} + +@media (min-width: 600px) { + div.cX-bin { + transform: scale(1); + } +} + + +/* Genie Effect */ + +.genie { + position: relative; + background-repeat: no-repeat; + background-size: cover; +} + +.genie .genie-step { + background-repeat: no-repeat; + background-image: inherit; + position: absolute; +} + +.genie.genie-expand .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-collapse .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +.genie.genie-collapse.change-pace .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-expand.change-pace .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +/* Hide Efect */ + +.appear { + transition: all 1s linear; + opacity: 1; +} + +.dissapear { + display: none; +} + +.dissapearHidden { + transition: all 1s linear; + opacity: 0; +} + +/* Magic Effects */ + + +/* +Magic - Ver 1.3.0 - https://minimamente.com +Licensed under the MIT license +Copyright (c) 2018 Christian Pucci +*/ + +.magictime { + -webkit-animation-duration: 1s; + animation-duration: 1s; + -webkit-animation-fill-mode: both; + animation-fill-mode: both; +} + +.showIn { + -webkit-animation-name: showIn; + animation-name: showIn; +} + +@-webkit-keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +@keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +.showOut { + -webkit-animation-name: showOut; + animation-name: showOut; +} + +@-webkit-keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +@keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +.puffIn { + -webkit-animation-name: puffIn; + animation-name: puffIn; +} + +@-webkit-keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.puffOut { + -webkit-animation-name: puffOut; + animation-name: puffOut; +} + +@-webkit-keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +@keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +.vanishIn { + -webkit-animation-name: vanishIn; + animation-name: vanishIn; +} + +@-webkit-keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.vanishOut { + -webkit-animation-name: vanishOut; + animation-name: vanishOut; +} + +@-webkit-keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.boingInUp { + -webkit-animation-name: boingInUp; + animation-name: boingInUp; +} + +@-webkit-keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.boingOutDown { + -webkit-animation-name: boingOutDown; + animation-name: boingOutDown; +} + +@-webkit-keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +@keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +.foolishIn { + -webkit-animation-name: foolishIn; + animation-name: foolishIn; +} + +@-webkit-keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +@keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +.foolishOut { + -webkit-animation-name: foolishOut; + animation-name: foolishOut; +} + +@-webkit-keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +@keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +.holeIn { + -webkit-animation-name: holeIn; + animation-name: holeIn; +} + +@-webkit-keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +@keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +.holeOut { + -webkit-animation-name: holeOut; + animation-name: holeOut; +} + +@-webkit-keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +@keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +.swashIn { + -webkit-animation-name: swashIn; + animation-name: swashIn; +} + +@-webkit-keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +@keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +.swashOut { + -webkit-animation-name: swashOut; + animation-name: swashOut; +} + +@-webkit-keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +@keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +.bombLeftOut { + -webkit-animation-name: bombLeftOut; + animation-name: bombLeftOut; +} + +@-webkit-keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.bombRightOut { + -webkit-animation-name: bombRightOut; + animation-name: bombRightOut; +} + +@-webkit-keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.magic { + -webkit-animation-name: magic; + animation-name: magic; +} + +@-webkit-keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +@keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +.swap { + -webkit-animation-name: swap; + animation-name: swap; +} + +@-webkit-keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +@keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +.twisterInDown { + -webkit-animation-name: twisterInDown; + animation-name: twisterInDown; +} + +@-webkit-keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +@keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +.twisterInUp { + -webkit-animation-name: twisterInUp; + animation-name: twisterInUp; +} + +@-webkit-keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +@keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +.spaceInDown { + -webkit-animation-name: spaceInDown; + animation-name: spaceInDown; +} + +@-webkit-keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInLeft { + -webkit-animation-name: spaceInLeft; + animation-name: spaceInLeft; +} + +@-webkit-keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInRight { + -webkit-animation-name: spaceInRight; + animation-name: spaceInRight; +} + +@-webkit-keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInUp { + -webkit-animation-name: spaceInUp; + animation-name: spaceInUp; +} + +@-webkit-keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceOutDown { + -webkit-animation-name: spaceOutDown; + animation-name: spaceOutDown; +} + +@-webkit-keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +@keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +.spaceOutLeft { + -webkit-animation-name: spaceOutLeft; + animation-name: spaceOutLeft; +} + +@-webkit-keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +@keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +.spaceOutRight { + -webkit-animation-name: spaceOutRight; + animation-name: spaceOutRight; +} + +@-webkit-keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +@keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +.spaceOutUp { + -webkit-animation-name: spaceOutUp; + animation-name: spaceOutUp; +} + +@-webkit-keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +@keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +.perspectiveDown { + -webkit-animation-name: perspectiveDown; + animation-name: perspectiveDown; +} + +@-webkit-keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +@keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +.perspectiveDownReturn { + -webkit-animation-name: perspectiveDownReturn; + animation-name: perspectiveDownReturn; +} + +@-webkit-keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.perspectiveLeft { + -webkit-animation-name: perspectiveLeft; + animation-name: perspectiveLeft; +} + +@-webkit-keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +@keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +.perspectiveLeftReturn { + -webkit-animation-name: perspectiveLeftReturn; + animation-name: perspectiveLeftReturn; +} + +@-webkit-keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveRight { + -webkit-animation-name: perspectiveRight; + animation-name: perspectiveRight; +} + +@-webkit-keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +@keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +.perspectiveRightReturn { + -webkit-animation-name: perspectiveRightReturn; + animation-name: perspectiveRightReturn; +} + +@-webkit-keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveUp { + -webkit-animation-name: perspectiveUp; + animation-name: perspectiveUp; +} + +@-webkit-keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +@keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +.perspectiveUpReturn { + -webkit-animation-name: perspectiveUpReturn; + animation-name: perspectiveUpReturn; +} + +@-webkit-keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.rotateDown { + -webkit-animation-name: rotateDown; + animation-name: rotateDown; +} + +@-webkit-keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +@keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +.rotateLeft { + -webkit-animation-name: rotateLeft; + animation-name: rotateLeft; +} + +@-webkit-keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +@keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +.rotateRight { + -webkit-animation-name: rotateRight; + animation-name: rotateRight; +} + +@-webkit-keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +@keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +.rotateUp { + -webkit-animation-name: rotateUp; + animation-name: rotateUp; +} + +@-webkit-keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +@keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +.slideDown { + -webkit-animation-name: slideDown; + animation-name: slideDown; +} + +@-webkit-keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown2 { + -webkit-animation-name: slideDown2; + animation-name: slideDown2; +} + +@-webkit-keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown3 { + -webkit-animation-name: slideDown3; + animation-name: slideDown3; +} + +@-webkit-keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDownReturn { + -webkit-animation-name: slideDownReturn; + animation-name: slideDownReturn; +} + +@-webkit-keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideDownReturn2 { + -webkit-animation-name: slideDownReturn2; + animation-name: slideDownReturn2; +} + +@-webkit-keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideLeft { + -webkit-animation-name: slideLeft; + animation-name: slideLeft; +} + +@-webkit-keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +@keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +.slideLeftReturn { + -webkit-animation-name: slideLeftReturn; + animation-name: slideLeftReturn; +} + +@-webkit-keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideLeftReturn2 { + -webkit-animation-name: slideLeftReturn2; + animation-name: slideLeftReturn2; +} + +@-webkit-keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideRight { + -webkit-animation-name: slideRight; + animation-name: slideRight; +} + +@-webkit-keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +@keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +.slideRightReturn { + -webkit-animation-name: slideRightReturn; + animation-name: slideRightReturn; +} + +@-webkit-keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideUp { + -webkit-animation-name: slideUp; + animation-name: slideUp; +} + +@-webkit-keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUp2 { + -webkit-animation-name: slideUp2; + animation-name: slideUp2; +} + +@-webkit-keyframes slideUp2 { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp2 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUpReturn { + -webkit-animation-name: slideUpReturn; + animation-name: slideUpReturn; +} + +@-webkit-keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideUpReturn2 { + -webkit-animation-name: slideUpReturn2; + animation-name: slideUpReturn2; +} + +@-webkit-keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.openDownLeft { + -webkit-animation-name: openDownLeft; + animation-name: openDownLeft; +} + +@-webkit-keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownLeftReturn { + -webkit-animation-name: openDownLeftReturn; + animation-name: openDownLeftReturn; +} + +@-webkit-keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownRight { + -webkit-animation-name: openDownRight; + animation-name: openDownRight; +} + +@-webkit-keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightReturn { + -webkit-animation-name: openDownRightReturn; + animation-name: openDownRightReturn; +} + +@-webkit-keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpLeft { + -webkit-animation-name: openUpLeft; + animation-name: openUpLeft; +} + +@-webkit-keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftReturn { + -webkit-animation-name: openUpLeftReturn; + animation-name: openUpLeftReturn; +} + +@-webkit-keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpRight { + -webkit-animation-name: openUpRight; + animation-name: openUpRight; +} + +@-webkit-keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightReturn { + -webkit-animation-name: openUpRightReturn; + animation-name: openUpRightReturn; +} + +@-webkit-keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownLeftOut { + -webkit-animation-name: openDownLeftOut; + animation-name: openDownLeftOut; +} + +@-webkit-keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightOut { + -webkit-animation-name: openDownRightOut; + animation-name: openDownRightOut; +} + +@-webkit-keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftOut { + -webkit-animation-name: openUpLeftOut; + animation-name: openUpLeftOut; +} + +@-webkit-keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightOut { + -webkit-animation-name: openUpRightOut; + animation-name: openUpRightOut; +} + +@-webkit-keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.tinDownIn { + -webkit-animation-name: tinDownIn; + animation-name: tinDownIn; +} + +@-webkit-keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinDownOut { + -webkit-animation-name: tinDownOut; + animation-name: tinDownOut; +} + +@-webkit-keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +@keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +.tinLeftIn { + -webkit-animation-name: tinLeftIn; + animation-name: tinLeftIn; +} + +@-webkit-keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinLeftOut { + -webkit-animation-name: tinLeftOut; + animation-name: tinLeftOut; +} + +@-webkit-keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +@keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +.tinRightIn { + -webkit-animation-name: tinRightIn; + animation-name: tinRightIn; +} + +@-webkit-keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinRightOut { + -webkit-animation-name: tinRightOut; + animation-name: tinRightOut; +} + +@-webkit-keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +@keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +.tinUpIn { + -webkit-animation-name: tinUpIn; + animation-name: tinUpIn; +} + +@-webkit-keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinUpOut { + -webkit-animation-name: tinUpOut; + animation-name: tinUpOut; +} + +@-webkit-keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +@keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +.blink { + -webkit-animation-name: blink; + animation-name: blink; +} + +@-webkit-keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} + +@keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} \ No newline at end of file diff --git a/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.min.js b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.min.js new file mode 100644 index 0000000..bef6f56 --- /dev/null +++ b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.min.js @@ -0,0 +1,303 @@ +/** + * + * CanvasXpress 58.7 - JavaScript Canvas Library + * + * Copyright (c) 2009-2025 - license@canvasxpress.org + * + * Redistributions of the source code must retain this copyright + * notice and the following disclaimer. + * + * CanvasXpress is released as open source for personal and + * educational use with dual licensing for commercial purposes. + * + * This program is distributed in the hope that it will be useful, + * but WITHOUT ANY WARRANTY; without even the implied warranty of + * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. + * + * Please see a copy of the CanvasXpress License at + * https://www.canvasxpress.org/docs/license.html. + * + * Dual licensing: + * Commercial use may be granted to the extent that this source + * code does NOT become part of any other Open Source or + * Commercially licensed development library or toolkit without + * explicit permission from CanvasXpress. + * + */ +/** + * + * sprintf() for JavaScript v.0.4 + * + * Copyright (c) 2007 Alexandru Marasteanu + * Thanks to David Baird (unit test and patch). + * + * This program is free software; you can redistribute it and/or modify it under + * the terms of the GNU General Public License as published by the Free Software + * Foundation; either version 2 of the License, or (at your option) any later + * version. + * + * This program is distributed in the hope that it will be useful, but WITHOUT + * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS + * FOR A PARTICULAR PURPOSE. See the GNU General Public License for more + * details. + * + * You should have received a copy of the GNU General Public License along with + * this program; if not, write to the Free Software Foundation, Inc., 59 Temple + * Place, Suite 330, Boston, MA 02111-1307 USA + * + *** + * + * Date Format 1.2.3 + * (c) 2007-2009 Steven Levithan + * MIT license + * + * Includes enhancements by Scott Trenda + * and Kris Kowal + * + * Accepts a date, a mask, or a date and a mask. + * Returns a formatted version of the given date. + * The date defaults to the current date/time. + * The mask defaults to dateFormat.masks.default. + * + **** + * + * jLouvain.js + * Author: Corneliu S. (github.com/upphiminn) + * This is a javascript implementation of the Louvain + * community detection algorithm (http://arxiv.org/abs/0803.0476) + * Based on https://bitbucket.org/taynaud/python-louvain/overview + * + **** + * + * science.js + * Copyright (c) 2011, Jason Davies + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * The name Jason Davies may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND + * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED + * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE + * DISCLAIMED. IN NO EVENT SHALL JASON DAVIES BE LIABLE FOR ANY DIRECT, INDIRECT, + * INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT + * LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR + * PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF + * LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE + * OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF + * ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * Apache-Style Software License for ColorBrewer software and ColorBrewer Color + * Schemes + * + * Copyright (c) 2002 Cynthia Brewer, Mark Harrower, and The Pennsylvania State + * University. + * + * Licensed under the Apache License, Version 2.0 (the "License"); you may not + * use this file except in compliance with the License. You may obtain a copy of + * the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, WITHOUT + * WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the + * License for the specific language governing permissions and limitations under + * the License. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * 1. Redistributions as source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * 2. The end-user documentation included with the redistribution, if any, must + * include the following acknowledgment: "This product includes color + * specifications and designs developed by Cynthia Brewer + * (http://colorbrewer.org/)." Alternately, this acknowledgment may appear in the + * software itself, if and wherever such third-party acknowledgments normally + * appear. + * + * 4. The name "ColorBrewer" must not be used to endorse or promote products + * derived from this software without prior written permission. For written + * permission, please contact Cynthia Brewer at cbrewer@psu.edu. + * + * 5. Products derived from this software may not be called "ColorBrewer", nor + * may "ColorBrewer" appear in their name, without prior written permission of + * Cynthia Brewer. + * + **** + * + * FileSaver.js + * Copyright © 2015 [Eli Grey][1]. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * canvas-toBlob.js + * Copyright © 2011 Eli Grey and Devin Samarin. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * Blob.js + * Copyright © 2014 Eli Grey. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * jstat.js + * Copyright (c) 2013 jStat + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * numeric.js + * Numeric Javascript + * Copyright (C) 2011 by Sébastien Loisel + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * Sankey.js + * Copyright (c) 2012, Michael Bostock + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * * The name Michael Bostock may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" + * AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE + * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE + * ARE DISCLAIMED. IN NO EVENT SHALL MICHAEL BOSTOCK BE LIABLE FOR ANY DIRECT, + * INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES + * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; + * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND + * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT + * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS + * SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * canvas2svg + * The MIT License (MIT) + * + * Copyright (c) 2014 Gliffy Inc. + * + * Permission is hereby granted, free of charge, to any person obtaining a copy of + * this software and associated documentation files (the "Software"), to deal in + * the Software without restriction, including without limitation the rights to + * use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of + * the Software, and to permit persons to whom the Software is furnished to do so, + * subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS + * FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR + * COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER + * IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + * CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + */ +(function(b,a){if(typeof exports==="object"){a(exports)}else{(a((b.CanvasXpress=b.CanvasXpress||{})))}}(this,(function(){CanvasXpress=typeof CanvasXpress!="undefined"&&CanvasXpress.ready?CanvasXpress:function(n,h,e,s,d,p,r,l){var k=this;var q=function(){k.init(n,h,e,s,d,p,r,l)};var c=function(i){if(i){k.init(i);if(r){r(i)}}else{k.init(n,h,e,s,d,p,r,l)}};var j=document.styleSheets;var b=false;for(var g=0;g-1){b=true;break}}if(e&&typeof e=="string"){e={prompt:e,llmBehaviour:"update",view:"table"}}else{if(n&&n.config&&n.config.prompt&&n.config.isR){n.config.llmBehaviour="update";n.config.view="table"}}if(!b){var 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provided")}else{if(typeof(f)=="object"&&f.renderTo){d=f.tracks?{tracks:f.tracks}:f.nodes?{nodes:f.nodes}:f.venn?{venn:f.venn}:f.data?f.data:false;b=f.config||false;if(f.version){b.createVersion=f.version}if(f.factory){b.createFactory=f.factory}c=f.events||false;e=f.info?f.info.replace(/'/g,"'").replace(/"/g,"'"):false;h=f.afterRender||false;g=f.callback||false;a=f.noValidate?f.noValidate:b&&b.noValidate?b.noValidate:false;f=f.renderTo;CanvasXpress.inject(f)}else{if(typeof f==="string"||f instanceof String){CanvasXpress.inject(f)}}}return{target:f,data:d,config:b,events:c,info:e,afterRender:h,callback:g,noValidate:a}};CanvasXpress.inject=function(c){if(typeof c==="string"||c instanceof String){var b=document.getElementById(c);if(b!==null){if(b.tagName.toLowerCase()=="canvas"){if(!b.width){b.width=500}if(!b.height){b.height=500}}else{if(b.tagName.toLowerCase()=="div"){b.id=c+"-div";var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;b.appendChild(a)}}}else{var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;document.body.appendChild(a)}}};CanvasXpress.loadFonts=function(d,c){if(d&&d.length&&c){var b=false;for(var a=0;a: "+k.parameters[l]+"

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z=document.createElement("div");z.style.width=w+"px";z.style.height="100px";z.style.clear="both";z.style.position="relative";z.style.margin="auto";var n=document.createElement("span");n.innerHTML=a.datetime;n.style.cssFloat="right";var d=document.createElement("span");d.innerHTML=a.prompt;d.style.cssFloat="left";d.style.fontWeight="bold";var y=document.createElement("span");y.innerHTML=a.client;y.style.cssFloat="left";var x=document.createElement("br");var v=document.createElement("br");var h=document.createElement("br");z.appendChild(x);z.appendChild(y);z.appendChild(n);z.appendChild(v);z.appendChild(d);z.appendChild(h);return z};var e=function(h,d){var n=document.createElement("div");if(d){n.className=d}n.appendChild(h);return n};var j=function(w,h){var x=CanvasXpress.parametersLLM;h.CZ();var n=h.meta.config.user;var d={graphOrientation:true,graphType:true,isR:true,prompt:true};for(var v=0;v=0){that.rY([vi,x,y]);draw=true}if(si>=0){that.rY([that.varIndices[0],si]);draw=true}}if(draw){that.z4()}}};var isPWC=function(){for(var i=0;i0?ar.shift():[];var cn=ar.length>0?ar.shift():{};var tm=ar.length>0?ar.shift():t;var rp=ar.length>0?ar.shift():false;if(this.view=="table"&&fn=="setDimensions"){continue}if(fn=="setDimensions"){if(this.width==pr[0]&&this.height==pr[1]){continue}}if(fn=="clickView"){cv=true;continue}if(fn=="updateDataFilter"||fn=="resetDataFilter"){this.skipRender=true}var dr=arr[i+1]&&arr[i+1][0]&&arr[i+1][0].match(/drag/i)?true:false;this.skipRender=fn=="createDOE"||fn=="createHistogram"||fn=="modifyColorScheme"||fn.match(/segregate/)||dr?false:!this.showTransition&&i0&&!CanvasXpress.readyFonts){CanvasXpress.readyFonts=true;return}t.fo("canvasXpress data ready - 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t=this;t.wu(o);t.GW("init");t.T4();t.gh(o);t.uU();t.Ki();t.Vd();t.YX();t.uo(o.config);t.y8();t.Pw();t.CI();t.jY(o.data);t.GW("initData");t.sb();t.EP();t.fR();t.zA();t.sw(o.data,o.config,o.events,o.info,o.afterRender);t.wE();t.Ki();t.c9(o.callback)};this.uY(o)};CanvasXpress.prototype.initStart=function(){this.initIO();this.initCrypt();this.initDOM();this.initViewport();this.initConfig()};CanvasXpress.prototype.initDataset=function(){this.yi=function(){delete (this.meta.data);this.cN(false,false,false,true)};this.af=function(c){if(c){this.meta.data={tracks:[]}}for(var H=0;HF){F=g;K=x[B].length;u=x[B]}}var e=[];for(var B=0;BI){I=h;O=B[H].length;A=B[H]}}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A;c.colors=[];var p=0;for(var H=0;HI){I=h;O=c.levels[H].toString().length;A=c.levels[H]}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A}c.shapes=this.shapes;c.sizes=this.sizes;c.patterns=this.patterns}P[E][G]=c}}}}if(this.decorations.length&&this.decorationsType=="heatmap"){var u=[];P.decorations={};P.decorations.unique=false;P.decorations.type="Numeric";P.decorations.n=0;for(var H=0;HI){I=h;O=P.decorations.levels[H].toString().length;A=P.decorations.levels[H]}P.decorations.maxLevLen=I;P.decorations.maxLevChr=O;P.decorations.maxLevStr=A}}}};this.FV=function(O,af,ac,P,ah){var J=this;var G=this.meta.config.user;var A=this.meta.data;var l=this.data;var C=CanvasXpress.colorSchemes;var p=["x","z","w"];var Y=this.font;var D=function(s,a,r,ai,al,ak){var t={};if(J.legendOrder&&J.legendOrder[s]){for(var aj=0;ajr[r.length-1]){t--;while(!C[J[ai+"Key"][U]][t]){t--}}else{if(td.length&&d.length==1&&J.graphType=="Map"){var t=S.length;var r=J.p4(C[J.colorScheme]);r.sort(function(aj,j){return aj-j});if(t>r[r.length-1]){t--;while(!C[J.colorScheme][t]){t--}}else{if(t10?d.colorBrew.vals:aj;d.order={};for(var s=0;sag){ag=t;c=d.levels[s].toString().length;aa=d.levels[s]}d.maxLevLen=ag;d.maxLevChr=c;d.maxLevStr=aa}}else{d[a+"s"]=a=="connect"?J.colors:J[a+"s"]}};if(!O||O=="w"||O=="x"||O=="z"){if(O&&ac){if(!af){delete (A[O])}else{if(A[O][af]){delete (A[O][af])}}}for(var X=0;Xag){ag=E;c=S[V].length;aa=S[V]}}I.maxLevLen=ag;I.maxLevChr=c;I.maxLevStr=aa;Z("color",this.colors,I);Z("shape",this.shapes,I);Z("size",this.Pk(S.length),I);Z("pattern",this.patterns,I);Z("linePattern",this.linePatterns,I);Z("connect",this.colors,I)}else{I.unique=false;I["boolean"]=false;for(var V=0;VA.m[T].maxFacLen){A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}else{A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}}if(P){return}var w,H,R;if(T=="z"){w="y";H="vars";R="Var"}if(T=="x"||T=="q"){w="y";H="smps";R="Smp"}if(T=="w"){w="w";H="smps";R="Smp"}var ag=0;var c=0;var aa="";if(l[w]){for(var V=0;Vthis.fullTextMeasureCheck){var L=l[w][H][V].toString().length;if(L>c){var E=this.HR(l[w][H][V],Y);if(E>ag){ag=E;c=L;aa=l[w][H][V]}}}else{if(l[w][H][V]!=null){var L=l[w][H][V].toString().length;if(L>=c){var E=this.HR(l[w][H][V].toString(),Y);if(E>ag){ag=E;c=L;aa=l[w][H][V].toString()}}}}}A[w]["max"+R+"Len"]=ag;A[w]["max"+R+"Chr"]=c;A[w]["max"+R+"Str"]=aa;A[w].vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";A[w].smps=this.nn(l.y.smps)?"World":this.RX(l.y.smps)?"USA":this.Ng(l.y.smps,true)?"Date":"String";if(A[w].smps=="Date"){A[w].date=this.vy(l.y.smps)}if(T=="x"){var ab={};var z=l.y.smps;for(var V=0;Vthis.fullTextMeasureCheck){var L=l.y.vars[V].toString().length;if(L>c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}else{if(l.y.vars[V]!=null){var L=l.y.vars[V].toString().length;if(L>=c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}}}A.y.maxVarLen=ag;A.y.maxVarChr=c;A.y.maxVarStr=aa;A.y.vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";if(!A.y.range){A.y.range={}}for(var V=0;Vag){ag=E;c=A[O].levels[V].toString().length;aa=A[O].levels[V]}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa}A[O].shapes=this.shapes;A[O].sizes=this.sizes;A[O].patterns=this.patterns}else{var S={};for(var V=0;Vag){ag=E;c=S[V].length;aa=S[V]}}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa;A[O].type="String";A[O].colors=[];var K=0;for(var V=0;V0){return true}else{if(a=="max"&&b.max&&b.max[0].length>0){return true}else{if(a=="min"&&b.min&&b.min[0].length>0){return true}else{if(a=="count"&&b.count&&b.count[0].length>0){return true}else{if(a=="mean"&&b.mean&&b.mean[0].length>0){return true}else{if(a=="median"&&b.median&&b.median[0].length>0){return true}else{if(a=="iqr"&&b.iqr1&&b.qtl1&&b.median&&b.qtl3&&b.iqr3&&b.median[0].length>0){return true}else{if(a=="raw"&&this.isRawData){return true}else{return false}}}}}}}}}}}}};this.we=function(aw,f,Q,ag,J){var W=this;var r=this.isDOE?this.data.l.data[this.layoutCurrent||0]:false;var t=this.isGroupedData&&!f&&this.data.w?this.data.w:this.data.y;var ah=this.graphType=="Scatter2D"&&this.scatterType=="visium"?CanvasXpress.cacheImages[this.backgroundImageMD5||this.va(this.backgroundImage)]:false;var w=this.Xs(true);var at=Number.POSITIVE_INFINITY;var K=Number.NEGATIVE_INFINITY;var A=Number.POSITIVE_INFINITY;var ab=Number.NEGATIVE_INFINITY;if(this.setMin!=null&&this.setMax!=null){this.minData=Number(this.setMin);this.maxData=Number(this.setMax);return}if(this.isGroupedData&&!aw&&!r){aw=this.graphType=="Boxplot"?"iqr":this.summaryType;if(this.graphType=="Boxplot"&&!this.isBoxplotCalc){this.cg(this.groupingFactors,false,false,false,true);t=this.data.w}}if(this.isGroupedData&&!f&&this.data.w&&!ag&&!r&&!this.layoutCurrent){for(var ak=0;ak=0?H:0;var Y=this.data.y.data[this.meterIndex];at=0;K=this.ob(Y,true)}else{if(w){var G=this.varIndices.length;for(var ak=0;ak=0){var ad=this.Ts(this.data.y.data[ap]);at=ad[0];K=ad[1]}else{at=0;K=1}}}else{if(aw=="gantt"){if(!this.data.gantt){this.isGanttDataFormated=false;this.ww()}var ak=this.as(this.ganttStart?this.ganttStart:this.xAxis[0]?this.xAxis[0]:this.data.y.vars[0]);this.ganttStart=this.data.y.vars[ak];var aj=this.as(this.ganttEnd?this.ganttEnd:this.xAxis[1]?this.xAxis[1]:this.data.y.vars[1]?this.data.y.vars[1]:this.data.y.vars[0]);this.ganttEnd=this.data.y.vars[aj]||this.data.y.vars[0];var ar=this.i4(this.data.gantt);at=ar[ak].sort(function(d,c){return d-c})[0];K=ar[aj].sort(function(d,c){return c-d})[0]}else{if(aw=="km"&&!f){if(!this.layoutValid){this.DO()}if(J=="y"){at=0;K=1}else{var ac=this.layoutValid&&this.meta.data.p.l.length?this.meta.data.p.l:this.meta.data.p.g;if(this.layoutValid&&this.meta.data.p.l.length){for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}}else{var G=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0){at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{if(Q){if(O>0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}}}}else{if(this.summaryType=="mean"&&!this.isRawData){var S=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0&&B>0){at=Math.min(D,at);K=Math.max(B,K)}}else{at=Math.min(D,at);K=Math.max(B,K)}}if(X){var T=X.length;for(var ai=0;ai0){at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}else{at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}}}}}}}else{if(aw=="cor"){var o=this.correlationAxis=="variables"?this.varIndices:this.isGroupedData?this.grpIndices:this.smpIndices;var S=o.length;for(var ak=0;ak0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}else{if(r){var C=J=="xAxis"?0:1;if(this.graphType=="Scatter2D"){for(var ak=0;ak0){if(ag){var V=this.graphType=="Circular"&&this.showIdeogram;var F=V?[this.varIndices,this.smpIndices]:[this.smpIndices,this.varIndices];var y=F[0].length;K=0;at=0;ab=0;A=0;for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}else{var S=this.motionBy||(this.isDOE&&this.isDOE==1)?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}if(this[J+"Transform"]=="sqrt"){at=Math.sqrt(at);K=Math.sqrt(K)}}}}}}}}}}}}}}}}}}}if(this.graphType=="Boxplot"&&this.showViolinBoxplot&&!this.violinTrim){var x=this.meta.data.d;if(this.isGroupedData){x=x.g;var S=x.length;for(var ak=0;ak1)&&!this.dataPointSizeScaleFactor&&this.scatterType=="stream"){if(J=="xAxis"){var I=(K-at)*this.scatterStreamExtraSpan;at-=I;K+=I}else{if(J=="yAxis"){this.b8();if(this.meta.data.s){var aa=this.layoutValid?this.meta.data.s.layout[this.layoutCurrent||0]:this.meta.data.s;switch(this.scatterStreamType){case"mirror":at=-aa.maxY;K=aa.maxY;break;case"ridge":at=0;K=aa.maxY*2;break;case"proportional":at=0;K=1;break}}}}}else{if(this.graphType=="Scatter2D"&&J=="yAxis"&&(this.showLoessFit||this.showRegressionFit||this.showQuantileRegressionFit)){if(this.showLoessFit){this.l1()}if(this.showRegressionFit){this.ba()}if(this.showQuantileRegressionFit){this.Tw()}if(this.meta.data.s){var af=this.meta.data.s;if(af.minY!=null&&af.minYNumber.NEGATIVE_INFINITY){if(this.dataPointSizeScaleFactor){at=Math.min(at,af.minY);K=Math.max(K,af.maxY)}else{at=af.minY;K=af.maxY}}}}}}}}}}if(this.decorations){if(this.decorations.error){for(var ak=0;ak=f&&d<=b))&&(e===null||(c>=e&&c<=a))){}else{if(q){this.filterFitIndices[q[h]]=true}else{this.filterFitIndices[r]=true}}}}for(var h=0;h=f&&d<=b))&&(e===null||(c>=e&&c<=a))){j.push(d);g.push(c)}}return[j,g]};this.WL=function(){var I=this;var K=[];var S=function(aw,an,aq){var aa=[];var aj=[];var q=aw.sets||[aw];var ah=0;if(!I.isDOE){for(var av=0;av0?aA[au][1]/ab.position.tot[au]:0);ae[au]=[ad.xy[au][0],ax[au]]}ab.filled[av]=ae.concat(ak.reverse())}if(aq!=null){var az=0;for(var av=0;av1&&I.meta.data.z&&I.meta.data.z.hasOwnProperty(I.segregateVariablesBy[1])){j=I.meta.data.z[I.segregateVariablesBy[1]].levels}}if(I.segregateSamplesBy.length){if(I.meta.data.z&&I.meta.data.z.hasOwnProperty(I.segregateSamplesBy[0])){aa=I.meta.data.z[I.segregateSamplesBy[0]].levels}else{if(I.segregateSamplesBy[0]=="sample"){aa=I.data.y.smps}}if(I.segregateSamplesBy.length>1&&I.meta.data.z&&I.meta.data.z.hasOwnProperty(I.segregateSamplesBy[1])){q=I.meta.data.z[I.segregateSamplesBy[1]].levels}}var k=(l.length||1)*(j.length||1)*(aa.length||1)*(q.length||1);if(ab.length&&ab.length==k){return true}else{return false}};var A=function(ag,ae){var ac=[];var ab=ae||I.segregateVariablesBy[ag];var aj=I.meta.data.z[ab].levels;var ap=I.data;if(!Z.hasOwnProperty("Factor")){Z.Factor={}}var ai=0;for(var am=0;amthis.maxDOENumber){break}}}else{for(var T=0;Tthis.maxDOENumber){break}}}o=true}}}else{if(this.graphType.match(/Scatter|Map/)){if(this.segregateVariablesBy.length&&this.meta.data.z&&this.meta.data.z.hasOwnProperty(this.segregateVariablesBy[0])){var Z=I.meta.data.s.density;var V=A(0);if(this.segregateVariablesBy.length==2||(this.showHistogram!=true&&this.showHistogram!=this.segregateVariablesBy[0])){var e=this.segregateVariablesBy.length==2?this.segregateVariablesBy[1]:this.showHistogram;var U=this.segregateVariablesBy.length==2?A(1):A(false,e);K=[];var h=this.meta.data.z[this.segregateVariablesBy[0]].levels;var f=this.meta.data.z[e].levels;var X=this.data;var N=0;for(var T=0;T5){try{b.loess[o+":"+h[d]]=this.Ed([q[0],q[1]],"Loess:"+o+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.loess[o+":"+h[d]].range[3])}catch(c){f.push(["setLoessData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.loess[o]=this.Ed([q[0],q[1]],"Global:"+o+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o].range[2]);b.maxY=Math.max(b.maxY,b.loess[o].range[3])}catch(c){f.push(["setLoessData",q[0].length,o,c])}}}}}};this.ba=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={regression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("regression")){this.meta.data.s.regression={}}}if(this.layoutValid&&this.meta.data.s.layout&&this.data.l&&this.data.l.comp&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e3){b.regression[p+":"+h[c]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[c]);b.minY=Math.min(b.minY,b.regression[p+":"+h[c]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[c]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[c],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,e,d,o);if(s[0].length>3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}else{for(var e=0;e3){b.regression[p+":"+h[d]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p+":"+h[d]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[d]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[d],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,l,r,o);if(s[0].length>=3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}};this.Tw=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={quantileRegression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("quantileRegression")){this.meta.data.s.quantileRegression={}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e5){try{b.quantileRegression[o+":"+h[d]]=this.Sm(q[0],q[1],this.quantiles,"QuantileRegression:"+o+":"+h[d]+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o+":"+h[d]])){b.minY=Math.min(b.minY,b.quantileRegression[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o+":"+h[d]].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.quantileRegression[o]=this.Sm(q[0],q[1],this.quantiles,"Global:"+o+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o])){b.minY=Math.min(b.minY,b.quantileRegression[o].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o,c])}}}}}};this.yc=function(b,o){if(!b){if(!this.meta.data.s||(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length)){if(!this.meta.data.s){this.meta.data.s={areas:{},layout:[]}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var f=0;f=0){t[0].push(l[r]);t[1].push(d[r]);s=r}else{if(e==0){t[0].push(h[e]);t[1].push(h[e]=0){g[0].push(r[q]);g[1].push(E[q])}else{g[0].push(k[w]);g[1].push(0)}}if(r.length>5){this.loessSpan=this.scatterStreamBandwidth?Math.max(0.1,this.scatterStreamBandwidth-0.45):0.3;try{var t=this.Ed([g[0],g[1]],"Stream"+s[y]+(D!=null?D:""));for(var w=0;w0){this.Ab();for(var c=0;c=1000){alert("Cannot exp transform values > 1000");return false}e=e=="exp2"?"exp2":"exp10"}}if(!g.trans){g.trans=[]}if(!g.tstdev){g.tstdev=[]}var f=this.motionBy?this.data.y.vars.length:this.isGroupedData?this.data.y.vars.length:!this.isDOE?this.data.y.vars.length:this.varIndices.length;for(var c=0;c0){var c=this.transformBase==2?"ratio2":"ratio10";var z=a.data[k][s]/e;var d=a.stdev[k][s];if(c=="ratio2"){a.trans[k][s]=Math.log(z)/Math.LN2;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN2}}else{if(c=="ratio10"){a.trans[k][s]=Math.log(z)/Math.LN10;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN10}}}}}}};this.Ph=function(s,p,o){var c=this.isGroupedData&&!this.graphType.match(/dotplot|boxplot/i)?this.data.w:this.data.y;var k=this.isGroupedData?false:true;var q;p=p?p:this.transformAxis;if(p=="samples"){for(var g=0;g1&&ah.includes("__FACTOR__")){ah=ah.filter(function(a){return a!="__FACTOR__"})}for(var Y=0;Y0?q.join(" :: "):"";if(!w.hasOwnProperty(B)){af.w.smps.push(B);P[B]=U;w[B]=[]}w[B].push(y)}this.isGroupedData=true;if(af.w.smps.length<1){af.w.smps=z;this.H9({func:"groupSamples",par:[ah,R,r,ac,c,C,ai]});return}if(this.isCxplot&&ah.length==1&&this.meta.data.x&&this.meta.data.x.hasOwnProperty(ah[0])&&this.meta.data.x[ah[0]].levels&&this.meta.data.x[ah[0]].type!="Numeric"){if(this.sortIncludeEmpty){if(this.meta.config.user.aes.hasOwnProperty("meta")){if(ah[0]==this.meta.config.user.aes.x&&this.meta.config.user.aes.meta.hasOwnProperty("xLabels")){var Z=this.eI(this.meta.config.user.aes.meta.xLabels);var ab=false;for(var Y=0;Y360){this.circularArc=360}else{if(this.circularArc<90){this.circularArc=90}}var y=this.circularArc*(Math.PI*2)/360;var p=(y-this.So(this.circularArcSectorSeparation)*(this.circularArc==360?B:B-1))/k;var h=[];var f=[];var C=0;for(var F=0;F=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}this.FV("y");this.YS(true,true);this.aS()}if(!c){this.H9({func:"uncountData",par:[]})}};this.K6=function(b,e){if(b){this.data.y.smps.push("__SEQ__");for(var a=0;a=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}}this.FV("y");this.YS(true,true);this.aS();if(!c){this.H9({func:"unsequenceData",par:[]})}};this.qR=function(){var u=this.isDOE?this.data.l.data[this.layoutCurrent]:false;var g=this.isDOE?u.y.data[0]:this.eI(this.data.y.data[this.meterIndex]);var t=this.isDOE?u.y.meter.group:this.groupingFactors.length?this.groupingFactors[0]:false;var e=this.isDOE?u.x[t]:t?this.eI(this.data.x[t]):false;var h=this.isDOE?u.y.meter.summary:this.summaryType;var c=this.isDOE?u.y.meter.topology:this.meterTopology;var p=t&&(!this.isDOE||this.isDOE==1)?this.meta.data.x[t]:t&&this.isDOE>1?this.meta.data.z[t]:false;var j=this.isDOE&&this.isDOE>1?this.varIndices:this.smpIndices;this.isMeterSummarized={data:g,count:g.length,sum:this.XX(g),mean:this.nd(g),max:this.ob(g)};var q=this.isMeterSummarized;var a=this.rangeSegments.length&&!this.isDOE?this.rangeSegments[this.rangeSegments.length-1]:false;switch(h){case"count":case"countTotal":q.value=q.count;q.scale=this[this.axisAlgorithm](0,a||q.count,5,false,this.axisWilkinsonLoose);q.reference=q.count;break;case"average":case"mean":case"raw":q.value=q.mean;q.scale=this[this.axisAlgorithm](0,a||q.max,5,false,this.axisWilkinsonLoose);q.reference=q.max;break;case"sum":case"sumTotal":q.value=q.sum;q.scale=this[this.axisAlgorithm](0,a||q.sum,5,false,this.axisWilkinsonLoose);q.reference=q.sum;break;case"percentage":case"percentageTotal":q.value=100;q.scale=this[this.axisAlgorithm](0,a||100,5,false,this.axisWilkinsonLoose);q.reference=100;break}q.range=a||q.scale[q.scale.length-1];var k=this.TM();var b=this.isDOE?this.layoutWidth:this.width-(this.marginLeft+this.marginRight);var o=(this.isDOE?this.layoutHeight:this.height)-(k+this.marginTop+this.marginBottom);if(t){if(p&&p.type=="String"){q.n=p.levels.length;let ratio=b/o;let inverseRatio=o/b;let condition=q.n<2&&c=="auto";let condition2=c=="auto"&&ratio>q.n-0.5;let condition3=c=="auto"&&inverseRatio>q.n-0.5;let condition4=c=="horizontal";let condition5=c=="vertical";if(condition||condition2||condition4){q.cols=q.n;q.rows=1}else{if(condition3||condition5){q.cols=1;q.rows=q.n}else{q.cols=Math.ceil(Math.sqrt(q.n));q.rows=Math.ceil(q.n/q.cols)}}q[t]={};q.levels=p.levels;for(var f=0;f0){l[g]++}}}if(!this.data.x){this.data.x={}}this.data.x.Sets=l;a=a.sort(function(s,j){return l[j]-l[s]});if(!this.upSetSets.length){a=a.splice(0,this.nUpSets)}this.isUpSetSumarized.vars=this.eI(a.reverse());a=this.iT(a);var b=[];var o=[];var r=[];var c=[];var e={};var h={};var k=[];for(var g=0;g0){b[g]++;if(a.hasOwnProperty(f)){o.push(f)}}}var q=o.join(":");if(!e.hasOwnProperty(q)){e[q]=[]}e[q].push(g)}this.isUpSetSumarized.inter=e;var p=[];for(var g in e){var d=g.split(":").length;h[g]=e[g].length;if(g!=""){p.push(g)}for(var f=0;f0){var k=[];var g=[];for(var h=0;h0){}this.treemapBy=k}var p=this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Map|Circular/)||this.graphType=="Tree";if(this.shapeBy&&!this.isMultidimensionalData&&!p){c+="shapeBy changed to false (shapeBy not support in"+this.graphType+")\n";this.shapeBy=false}else{if(this.shapeBy&&this.groupingFactors.length>1&&!p){c+="shapeBy changed to variable (multiple grouping factors not allowed)\n";this.shapeBy="variable"}else{if(this.shapeBy&&this.groupingFactors.length==1&&this.shapeBy!=this.groupingFactors[0]&&!p){c+="shapeBy changed to variable (grouping factor should the same as shapeBy)\n";this.shapeBy="variable"}}}if(this.sizeBy&&!this.isMultidimensionalData&&!p){c+="sizeBy changed to false (sizeBy not support in"+this.graphType+")\n";this.sizeBy=false}else{if(this.sizeBy&&this.groupingFactors.length>1&&!p){c+="sizeBy changed to variable (multiple grouping factors not allowed)\n";this.sizeBy="variable"}else{if(this.sizeBy&&this.groupingFactors.length==1&&this.sizeBy!=this.groupingFactors[0]&&!p){c+="sizeBy changed to variable (grouping factor should the same as sizeBy)\n";this.sizeBy="variable"}}}if(this.colorBy&&this.graphType=="Heatmap"&&!this.isMultidimensionalData){this.lX(this.colorBy)}else{if(this.graphType=="Heatmap"&&this.heatmapType=="split"&&b){this.cq()}else{if(this.colorBy&&this.groupingFactors.length>1&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap/)&&!this.isCxplot){c+="colorBy changed to variable (multiple grouping factors not allowed)\n";this.colorBy="variable"}else{if(this.colorBy&&this.groupingFactors.length==1&&this.colorBy!=this.groupingFactors[0]&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap|Line/)&&this.barType!="swimmer"){if(this.toDoPivot){this.colorBy=false}else{c+="colorBy changed to variable (grouping factor should the same as colorBy)\n";this.colorBy="variable"}}}}}if((this.shapeBy||this.sizeBy||this.patternBy||this.outlineBy)&&!this.colorBy&&!this.isMultidimensionalData&&!this.graphType=="Heatmap"&&!this.isCxplot){this.colorBy="variable"}else{if(!this.shapeBy&&!this.sizeBy&&!this.patternBy&&this.colorBy=="variable"&&this.graphType!="Map"){this.colorBy=o()}}if(this.shapeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.sizeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.patternBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.stackBy&&!this.colorBy){this.colorBy=this.stackBy}else{if(this.stackBy&&this.colorBy&&this.stackBy!=this.colorBy){c+="colorBy changed to stackBy (remove stackBy to color by different factor)\n";this.colorBy=this.stackBy}}if(this.dodgeBy&&!this.colorBy){this.colorBy=this.dodgeBy}else{if(this.dodgeBy&&this.colorBy&&this.dodgeBy!=this.colorBy){c+="colorBy changed to dodgeBy (remove dodgeBy to color by different factor)\n";this.colorBy=this.dodgeBy}}if(this.lineBy&&!this.colorBy&&this.isGroupedData){}else{if(this.lineBy&&this.colorBy&&this.lineBy!=this.colorBy&&this.isGroupedData){c+="colorBy changed to lineBy (remove lineBy to color by different factor)\n";this.colorBy=this.lineBy}else{if(this.lineBy&&!this.isGroupedData&&this.graphType!="Scatter2D"){c+="Data needs to be grouped";this.lineBy=false}}}if(c!=""){this.n6(10,10,c,3000)}if(this.colorBy||this.shapeBy||this.sizeBy||this.lineBy){var q=["colorBy","shapeBy","lineBy"];var t=[];for(var h=0;h=0&&o.w.grps[E]){for(var g=0;g1){return false}}}return true};var f=function(){if(!e.patternBy){if(G>e.colors.length-1&&!e.colorBy){return e[z[F]][Math.floor(G/e.colors.length)]}else{return e[z[F]][0]}}else{return e[z[F]][0]}};var r=F&&this[z[F]]?this[z[F]].length:false;if(G!=null&&E!=null&&u&&o.y.hasOwnProperty(u)){y=o.y[u][G][E];x=H[u];j=x.type}else{if(E!=null&&u&&o.x&&o.x.hasOwnProperty(u)){x=H.x[u];if(C||!this.isGroupedData){j=x.type;y=this.graphType=="Gantt"?o.x[u][E]:this.isGroupedData?o.w.smps[E]:o.x[u][E];if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(F=="colorSmpDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}}}else{if((A&&(this.groupingFactors[0]==u||d()))||(!A&&this.isGroupedData&&this.isCxplot&&this.groupingFactors.length>1)){j=x.type;y=E!==false&&E>=0&&o.w.grps[E]?o.x[u][o.w.grps[E][0]]:false;if(y&&F.match(/color|patternBy/)){if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(x[z[F]]){return x[z[F]][x.order[y]%r]}else{return this[z[F]][x.order[y]%r]}}}else{return x[z[F]]?x[z[F]][0]:F.match(/color/)?this[z[F]][0]:F=="patternBy"?f():this[z[F]][0]}}else{return G!=null&&F.match(/color/)?this[z[F]][G%r]:F=="patternBy"?f():this[z[F]][0]}}}else{if(G!=null&&u&&o.z&&o.z.hasOwnProperty(u)){x=H.z[u];j=x.type;y=o.z[u][G];if(x[F]&&(x[F].hasOwnProperty(y)||x[F][y])){return x[F][y]}else{if(x[F]&&(x[F].hasOwnProperty(y+"\x00")||x[F][y+"\x00"])){return x[F][y+"\x00"]}else{if(x[F]&&x[F][y.replace("\x00","")]){return x[F][y.replace("\x00","")]}else{if(F=="colorVarDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}else{if(x[F]&&F=="linePatterns"&&x.order&&x.order.hasOwnProperty(y)){return x[F][x.order[y]%this[F].length]}}}}}}else{if(G!=null&&E!=null&&F&&((this.isGroupedData&&H.w.smps.hasOwnProperty(F))||(!this.isGroupedData&&H.y.range.hasOwnProperty(F)))){y=o.y.data[G][E];x=H.y.range[F];j=H.y.type}else{if(G!=null&&!this.isGroupedData&&u&&H.y.range.hasOwnProperty(u)){x=H.y.range[u];j=x.type;k=E!=null?false:this.sF(u);y=E!=null?o.y.data[G][E]:o.y.data[G]?o.y.data[G][k>=0?k:0]:0;if(H.modified&&H.modified.z&&H.modified.z[u]){return 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a=c.toLowerCase().replace(/ /g,"");switch(a){case"grey":case"gray":case"igray":case"ggplot":return CanvasXpress.themeDef.grey;case"bw":case"blackandwhite":return CanvasXpress.themeDef.bw;case"linedraw":return CanvasXpress.themeDef.linedraw;case"light":return CanvasXpress.themeDef.light;case"dark":return CanvasXpress.themeDef.dark;case"minimal":return CanvasXpress.themeDef.minimal;case"classic":return CanvasXpress.themeDef.classic;case"void":case"void0":return CanvasXpress.themeDef.void0;case"economist":return CanvasXpress.themeDef.economist;case"excel":return CanvasXpress.themeDef.excel;case"solarized":return CanvasXpress.themeDef.solarized;case"paulTol":case"paultol":case"ptol":return CanvasXpress.themeDef.ptol;case"highcharts":return CanvasXpress.themeDef.highcharts;case"wallstreetjournal":case"wallstreet":case"wsj":return CanvasXpress.themeDef.wsj;case"tableau":return CanvasXpress.themeDef.tableau;case"stata":return CanvasXpress.themeDef.stata;case"ggblanket":return CanvasXpress.themeDef.ggblanket;case"cx":case"canvasxpress":return CanvasXpress.themeDef.cx;case"cxdark":case"canvasxpressdark":return CanvasXpress.themeDef.cxdark;case"cx2":case"canvasxpresstraditional":return CanvasXpress.themeDef.grey;default:var b=this.eI(CanvasXpress.themeDef.light);b["panel.border.colour"]=null;return b}};this.L3=function(b){if(!b){b="x"}var e=["AxisShow","Axis2Show","AxisTitleColor","AxisTitleScaleFontFactor","AxisTextColor","AxisTextScaleFontFactor","AxisTicksShow","AxisTicksColor","AxisTicksLength","AxisTicksWidth","AxisLineBottomShow","AxisLineBottomColor","AxisLineBottomLineType","AxisLineBottomWidth","AxisLineTopShow","AxisLineTopColor","AxisLineTopLineType","AxisLineTopWidth","AxisGridMajorShow","AxisGridMajorColor","AxisGridMajorLineType","AxisGridMajorWidth","AxisGridMinorShow","AxisGridMinorColor","AxisGridMinorLineType","AxisGridMinorWidth"];var f=["r","z"];for(var d=0;d0&&!this.skipTransition&&this.showTransition){delete 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e&&e.classList?e.classList.contains(n):false};this.X0=function(e,n){if(e){e.classList.add(n)}};this.Tg=function(e,n){if(e){e.classList.remove(n)}};this.Rs=function(e,r,a){if(e){e.classList.remove(r);e.classList.add(a)}};this.md=function(e){var s="";var o=getComputedStyle(e);for(var i=0;i0?1:-1)*Math.floor(Math.abs(number))};var maxSafeInteger=Math.pow(2,53)-1;var toLength=function(value){var len=toInteger(value);return Math.min(Math.max(len,0),maxSafeInteger)};return function from(arrayLike){var C=this;var items=Object(arrayLike);if(arrayLike==null){throw new TypeError("Array.from requires an array-like object - not null or undefined")}var mapFn=arguments.length>1?arguments[1]:void undefined;var T;if(typeof mapFn!=="undefined"){if(!isCallable(mapFn)){throw new TypeError("Array.from: when provided, the second argument must be a function")}if(arguments.length>2){T=arguments[2]}}var len=toLength(items.length);var A=isCallable(C)?Object(new C(len)):new Array(len);var k=0;var kValue;while(k>>0;var start=arguments[1];var relativeStart=start>>0;var k=relativeStart<0?Math.max(len+relativeStart,0):Math.min(relativeStart,len);var end=arguments[2];var relativeEnd=end===undefined?len:end>>0;var finl=relativeEnd<0?Math.max(len+relativeEnd,0):Math.min(relativeEnd,len);while(k>>0;if(typeof callback!=="function"){throw new TypeError(callback+" is not a function")}if(arguments.length>1){T=arguments[1]}A=new Array(len);k=0;while(k>>0;if(typeof predicate!=="function"){throw new TypeError("predicate must be a function")}var thisArg=arguments[1];var k=0;while(k>>0;if(len===0){return false}var n=fromIndex|0;var k=Math.max(n>=0?n:len-Math.abs(n),0);function sameValueZero(x,y){return x===y||(typeof x==="number"&&typeof y==="number"&&isNaN(x)&&isNaN(y))}while(kA){var G=A;A=u;u=G}}var o=this.Fe(u,A,4);u=o[0];A=o[o.length-1];var y=A-u;var a=(((y*1000000)-(parseInt(y)*1000000))/1000000).toString().replace(/\./,"").length-1;var e=Math.pow(1/10,(a+1));var C=u>0?Math.log10(u):u==0?0:null;var E=A>0?Math.log10(A):A==0?0:null;var c=[];var Q="CanvasXpressRangeSlider";if(C!=null&&E!=null){var I=this.Fe(C,E,4);for(var B=0;B1){m=l;m.width=arguments[0];m.height=arguments[1]}else{if(!n){m=l}else{m=n}}if(!(this instanceof k)){return new k(m)}this.width=m.width||l.width;this.height=m.height||l.height;this.desc=m.desc||l.desc;this.enableMirroring=m.enableMirroring!==undefined?m.enableMirroring:l.enableMirroring;this.canvas=this;this.__document=m.document||document;if(m.ctx){this.__ctx=m.ctx}else{this.__canvas=this.__document.createElement("canvas");this.__ctx=this.__canvas.getContext("2d")}this.__setDefaultStyles();this.__stack=[this.__getStyleState()];this.__groupStack=[];this.__root=this.__document.createElementNS("http://www.w3.org/2000/svg","svg");this.__root.setAttribute("version",1.1);this.__root.setAttribute("xmlns","http://www.w3.org/2000/svg");this.__root.setAttributeNS("http://www.w3.org/2000/xmlns/","xmlns:xlink","http://www.w3.org/1999/xlink");this.__root.setAttribute("width",this.width);this.__root.setAttribute("height",this.height);this.__root.setAttribute("desc",this.desc);this.__ids={};this.__defs=this.__document.createElementNS("http://www.w3.org/2000/svg","defs");this.__root.appendChild(this.__defs);this.__currentElement=this.__document.createElementNS("http://www.w3.org/2000/svg","g");this.__root.appendChild(this.__currentElement)};k.prototype.__createElement=function(l,p,r){if(typeof 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    + + + + +
    +
    +

    Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES

    + + + Source: vignettes/drugbank_nside.Rmd +
    drugbank_nside.Rmd
    +
    + + + +
    +

    Introduction +

    +

    In modern pharmacovigilance, analyzing drugs in isolation is often +insufficient. Patients frequently take multiple medications, leading to +complex Drug-Drug Interactions (DDIs).

    +

    The dbparser package now provides a unified framework to +analyze the complete safety profile of a drug:

    +
      +
    1. +Mechanism: Biological targets and pathways from +DrugBank.
      2. +
    2. +Phenotype (Single Drug): Real-world adverse events +from OnSIDES.
      3. +
    3. +Polypharmacy (Combinations): Interaction risks from +TWOSIDES.
      4. +
    +

    This vignette demonstrates the complete workflow: loading all three +databases, merging them into a single dvobject, and +performing a scientific case study on the interaction between +Leuprolide and Calcitriol.

    +
    +
    +

    Prerequisites +

    + +
    +
    +

    1. Loading and Inspecting Data +

    +

    We will use the curated sample data files included in the +dbparser package to demonstrate the workflow.

    +
    +

    1.1 Load DrugBank (The Hub) +

    +

    First, we load the mechanistic data.

    +
    +# Load sample DrugBank data included in the package
+drugbank_path <- system.file("two_drugs.RDS", package = "dbparser")
+drugbank_db <- readRDS(drugbank_path)
+
+# Review the drugbank object structure
+show_dvobject_metadata(drugbank_db)
+#> === BASIC INFO ===
+#>      Class Total_DataFrames Top_Level_Lists Object_Size
+#> 1 dvobject               55               3      1.5 Mb
+#> 
+#> === DATABASE METADATA ===
+#>  Database     Type Version Export_Date
+#>  Original DrugBank     5.1  2025-01-02
+#> 
+#> === DATA.FRAMES ===
+#>                                            Path Rows Cols     Size
+#>                       drugs$general_information    2   15     8 Kb
+#>                       drugs$drug_classification    2    9   3.8 Kb
+#>                                  drugs$synonyms   15    4   3.6 Kb
+#>                              drugs$pharmacology    2   12  18.1 Kb
+#>                      drugs$international_brands    9    3   2.7 Kb
+#>                                  drugs$mixtures    5    3     2 Kb
+#>                                 drugs$packagers   35    3   6.2 Kb
+#>                             drugs$manufacturers   13    4   2.9 Kb
+#>                                    drugs$prices   16    5   4.6 Kb
+#>                                drugs$categories   58    3   9.2 Kb
+#>                                   drugs$dosages  189    4  17.4 Kb
+#>                                 drugs$atc_codes    4   10   4.3 Kb
+#>                                   drugs$patents   35    6   8.6 Kb
+#>                         drugs$drug_interactions 1645    4 514.7 Kb
+#>                                 drugs$sequences    1    3   1.3 Kb
+#>                     drugs$calculated_properties   26    4   5.6 Kb
+#>                   drugs$experimental_properties    5    4   2.4 Kb
+#>                      drugs$external_identifiers   30    3   4.7 Kb
+#>                               drugs$pdb_entries   19    2   2.4 Kb
+#>                        drugs$affected_organisms    2    2   1.2 Kb
+#>                                    drugs$groups    4    2   1.3 Kb
+#>                            drugs$external_links    5    3   2.1 Kb
+#>                                           salts    2    8   2.8 Kb
+#>                                        products  190   19  68.6 Kb
+#>                       references$drugs$articles   13    4   6.3 Kb
+#>                          references$drugs$links   11    4   6.1 Kb
+#>                       references$carriers$books    1    4   1.6 Kb
+#>                    references$carriers$articles   15    4   5.4 Kb
+#>                        references$enzymes$books   33    4   8.2 Kb
+#>                     references$enzymes$articles 1573    4 485.5 Kb
+#>                        references$enzymes$links  615    4 164.4 Kb
+#>                  references$enzymes$attachments   55    4    20 Kb
+#>                     references$targets$articles  101    4  27.4 Kb
+#>                        references$targets$links   14    4   7.1 Kb
+#>               cett$carriers$general_information    1    6   1.9 Kb
+#>                           cett$carriers$actions    2    2   1.2 Kb
+#>  cett$carriers$polypeptides$general_information    1   20   6.8 Kb
+#>      cett$carriers$polypeptides$external_identy    7    3   2.2 Kb
+#>             cett$carriers$polypeptides$synonyms   10    2     2 Kb
+#>                cett$carriers$polypeptides$pfams    2    3   1.5 Kb
+#>                   cett$carriers$polypeptides$go    2    3   1.5 Kb
+#>                cett$enzymes$general_information    2    8   2.6 Kb
+#>                            cett$enzymes$actions    7    2   1.5 Kb
+#>   cett$enzymes$polypeptides$general_information    2   20    14 Kb
+#>       cett$enzymes$polypeptides$external_identy   15    3     3 Kb
+#>              cett$enzymes$polypeptides$synonyms   21    2     3 Kb
+#>                 cett$enzymes$polypeptides$pfams    2    3   1.4 Kb
+#>                    cett$enzymes$polypeptides$go   21    3   3.6 Kb
+#>                cett$targets$general_information    4    6   2.6 Kb
+#>                            cett$targets$actions   10    2   1.9 Kb
+#>   cett$targets$polypeptides$general_information    4   20  14.2 Kb
+#>       cett$targets$polypeptides$external_identy   26    3   3.9 Kb
+#>              cett$targets$polypeptides$synonyms   15    2   2.4 Kb
+#>                 cett$targets$polypeptides$pfams    5    3   2.1 Kb
+#>                    cett$targets$polypeptides$go   37    3   5.6 Kb
    +
    +
    +

    1.2 Load OnSIDES (Single-Drug Labels) +

    +

    Next, we load the adverse event data extracted from FDA labels.

    +
    +# Load sample OnSIDES data included in the package
+onsides_path <- system.file("onside.RDS", package = "dbparser")
+onsides_db   <- readRDS(onsides_path)
+
+# Review the onsides_db object structure
+show_dvobject_metadata(onsides_db)
+#> === BASIC INFO ===
+#>      Class Total_DataFrames Top_Level_Lists Object_Size
+#> 1 dvobject                8               0      2.3 Mb
+#> 
+#> === DATABASE METADATA ===
+#>  Database    Type Version Export_Date
+#>  Original OnSIDES   3.1.1  April 2025
+#> 
+#> === DATA.FRAMES ===
+#>                                Path  Rows Cols    Size
+#>              product_adverse_effect 52745    7  2.2 Mb
+#>                     high_confidence     2    2  1.4 Kb
+#>                       product_label    95    5 39.7 Kb
+#>                   product_to_rxnorm   160    2  5.5 Kb
+#>  vocab_rxnorm_ingredient_to_product    17    2  2.7 Kb
+#>         vocab_meddra_adverse_effect   347    3 31.6 Kb
+#>             vocab_rxnorm_ingredient     3    3  2.1 Kb
+#>                vocab_rxnorm_product    17    3  4.9 Kb
    +
    +
    +

    1.3 Load TWOSIDES (Drug Interactions) +

    +

    Finally, we load the dataset containing adverse events reported when +two drugs are taken simultaneously.

    +
    +# Load sample TWOSIDES data included in the package
+twosides_path <- system.file("twoside_raw.zip", package = "dbparser")
+
+if(file.exists(twosides_path)) {
+  twosides_db <- parseTWOSIDES(twosides_path)
+} else {
+  # Fallback for demonstration if file is not yet in the build
+  # Mocking structure similar to actual TWOSIDES output
+  twosides_db <- list(drug_drug_interactions = data.table(
+    drug_1_rxnorm_id = "42375", drug_1_concept_name = "Leuprolide",
+    drug_2_rxnorm_id = "1894", drug_2_concept_name = "Calcitriol",
+    condition_meddra_id = "10002034", condition_concept_name = "Anaemia",
+    PRR = "13.33", mean_reporting_frequency = "0.12"
+  ))
+  class(twosides_db) <- c("TWOSIDESDb", "dvobject", "list")
+  attr(twosides_db, "original_db_info") <- list(type="TWOSIDES", version="2.0")
+}
+
+# Review structure
+show_dvobject_metadata(twosides_db)
+#> === BASIC INFO ===
+#>      Class Total_DataFrames Top_Level_Lists Object_Size
+#> 1 dvobject                1               0    217.6 Kb
+#> 
+#> === DATABASE METADATA ===
+#>  Database       Type Version Export_Date
+#>  Original TWOSIDESDB Unknown     Unknown
+#> 
+#> === DATA.FRAMES ===
+#>                    Path Rows Cols     Size
+#>  drug_drug_interactions 1706   13 216.6 Kb
    +
    +
    +
    +

    2. Merging the Databases (Chaining) +

    +

    We integrate the databases in a chain. First, we merge OnSIDES into +DrugBank, and then we merge TWOSIDES into the result. This creates a +single “Hub and Spoke” object centered on DrugBank.

    +
    +# Step 1: Merge DrugBank + OnSIDES
+db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db)
+
+# Step 2: Merge Result + TWOSIDES
+# The function is chainable and automatically detects the existing data
+final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db)
+
+# Review final object structure
+# Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data'
+show_dvobject_metadata(final_db)
+#> === BASIC INFO ===
+#>                                             Class Total_DataFrames
+#> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject               68
+#>   Top_Level_Lists Object_Size
+#> 1               4      4.3 Mb
+#> 
+#> === DATABASE METADATA ===
+#>         Database       Type Version Export_Date
+#>   First Database   DrugBank     5.1  2025-01-02
+#>  Second Database TWOSIDESDB Unknown     Unknown
+#> 
+#> === DATA.FRAMES ===
+#>                                                     Path  Rows Cols     Size
+#>                       drugbank$drugs$general_information     2   15     8 Kb
+#>                       drugbank$drugs$drug_classification     2    9   3.8 Kb
+#>                                  drugbank$drugs$synonyms    15    4   3.6 Kb
+#>                              drugbank$drugs$pharmacology     2   12  18.1 Kb
+#>                      drugbank$drugs$international_brands     9    3   2.7 Kb
+#>                                  drugbank$drugs$mixtures     5    3     2 Kb
+#>                                 drugbank$drugs$packagers    35    3   6.2 Kb
+#>                             drugbank$drugs$manufacturers    13    4   2.9 Kb
+#>                                    drugbank$drugs$prices    16    5   4.6 Kb
+#>                                drugbank$drugs$categories    58    3   9.2 Kb
+#>                                   drugbank$drugs$dosages   189    4  17.4 Kb
+#>                                 drugbank$drugs$atc_codes     4   10   4.3 Kb
+#>                                   drugbank$drugs$patents    35    6   8.6 Kb
+#>                         drugbank$drugs$drug_interactions  1645    4 514.7 Kb
+#>                                 drugbank$drugs$sequences     1    3   1.3 Kb
+#>                     drugbank$drugs$calculated_properties    26    4   5.6 Kb
+#>                   drugbank$drugs$experimental_properties     5    4   2.4 Kb
+#>                      drugbank$drugs$external_identifiers    30    3   4.7 Kb
+#>                               drugbank$drugs$pdb_entries    19    2   2.4 Kb
+#>                        drugbank$drugs$affected_organisms     2    2   1.2 Kb
+#>                                    drugbank$drugs$groups     4    2   1.3 Kb
+#>                            drugbank$drugs$external_links     5    3   2.1 Kb
+#>                                           drugbank$salts     2    8   2.8 Kb
+#>                                        drugbank$products   190   19  68.6 Kb
+#>                       drugbank$references$drugs$articles    13    4   6.3 Kb
+#>                          drugbank$references$drugs$links    11    4   6.1 Kb
+#>                       drugbank$references$carriers$books     1    4   1.6 Kb
+#>                    drugbank$references$carriers$articles    15    4   5.4 Kb
+#>                        drugbank$references$enzymes$books    33    4   8.2 Kb
+#>                     drugbank$references$enzymes$articles  1573    4 485.5 Kb
+#>                        drugbank$references$enzymes$links   615    4 164.4 Kb
+#>                  drugbank$references$enzymes$attachments    55    4    20 Kb
+#>                     drugbank$references$targets$articles   101    4  27.4 Kb
+#>                        drugbank$references$targets$links    14    4   7.1 Kb
+#>               drugbank$cett$carriers$general_information     1    6   1.9 Kb
+#>                           drugbank$cett$carriers$actions     2    2   1.2 Kb
+#>  drugbank$cett$carriers$polypeptides$general_information     1   20   6.8 Kb
+#>      drugbank$cett$carriers$polypeptides$external_identy     7    3   2.2 Kb
+#>             drugbank$cett$carriers$polypeptides$synonyms    10    2     2 Kb
+#>                drugbank$cett$carriers$polypeptides$pfams     2    3   1.5 Kb
+#>                   drugbank$cett$carriers$polypeptides$go     2    3   1.5 Kb
+#>                drugbank$cett$enzymes$general_information     2    8   2.6 Kb
+#>                            drugbank$cett$enzymes$actions     7    2   1.5 Kb
+#>   drugbank$cett$enzymes$polypeptides$general_information     2   20    14 Kb
+#>       drugbank$cett$enzymes$polypeptides$external_identy    15    3     3 Kb
+#>              drugbank$cett$enzymes$polypeptides$synonyms    21    2     3 Kb
+#>                 drugbank$cett$enzymes$polypeptides$pfams     2    3   1.4 Kb
+#>                    drugbank$cett$enzymes$polypeptides$go    21    3   3.6 Kb
+#>                drugbank$cett$targets$general_information     4    6   2.6 Kb
+#>                            drugbank$cett$targets$actions    10    2   1.9 Kb
+#>   drugbank$cett$targets$polypeptides$general_information     4   20  14.2 Kb
+#>       drugbank$cett$targets$polypeptides$external_identy    26    3   3.9 Kb
+#>              drugbank$cett$targets$polypeptides$synonyms    15    2   2.4 Kb
+#>                 drugbank$cett$targets$polypeptides$pfams     5    3   2.1 Kb
+#>                    drugbank$cett$targets$polypeptides$go    37    3   5.6 Kb
+#>                           onsides$product_adverse_effect 52745    7   2.2 Mb
+#>                                  onsides$high_confidence     2    2   1.4 Kb
+#>                                    onsides$product_label    95    5  39.7 Kb
+#>                                onsides$product_to_rxnorm   160    2   5.5 Kb
+#>               onsides$vocab_rxnorm_ingredient_to_product    17    2   2.7 Kb
+#>                      onsides$vocab_meddra_adverse_effect   347    3  31.6 Kb
+#>                          onsides$vocab_rxnorm_ingredient     3    3   2.1 Kb
+#>                             onsides$vocab_rxnorm_product    17    3   4.9 Kb
+#>         integrated_data$vocab_rxnorm_ingredient_enriched     3    4   2.3 Kb
+#>                 integrated_data$high_confidence_enriched     2    3   1.6 Kb
+#>                   integrated_data$DrugBank_RxCUI_Mapping     2    2   1.2 Kb
+#>                   integrated_data$drug_drug_interactions  1706   17 300.9 Kb
+#>                          twosides$drug_drug_interactions  1706   13 216.6 Kb
    +
    +
    +

    3. Single Drug Analysis: Leuprolide (DB00007) +

    +

    Scientific Context: Leuprolide is a GnRH analog. We +first establish its baseline side effect profile from OnSIDES.

    +
    +target_drug_id <- "DB00007" # Leuprolide
+
+# 1. Get the RxNorm ID from the bridge table
+mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>%
+  filter(drugbank_id == target_drug_id)
+
+target_rxcui <- mapping_df$rxcui[1]
+print(paste0("DrugBank ID: ", target_drug_id, " maps to RxNorm CUI: ", target_rxcui))
+#> [1] "DrugBank ID: DB00007 maps to RxNorm CUI: 42375"
    +
    +

    3.1 Extract Baseline Adverse Events (OnSIDES) +

    +
    +# 1. Find product labels linked to this ingredient
+product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>%
+  filter(ingredient_id == target_rxcui) %>%
+  pull(product_id)
+
+target_label_ids <- final_db$onsides$product_to_rxnorm %>%
+  filter(rxnorm_product_id %in% product_rxcuis) %>%
+  pull(label_id)
+
+# 2. Extract and summarize events
+ae_summary <- final_db$onsides$product_adverse_effect %>%
+  filter(product_label_id %in% target_label_ids) %>%
+  group_by(effect_meddra_id) %>%
+  summarise(Count = n()) %>%
+  arrange(desc(Count)) %>%
+  head(10) %>%
+  left_join(final_db$onsides$vocab_meddra_adverse_effect, 
+            by = c("effect_meddra_id" = "meddra_id")) %>%
+  select(effect_meddra_id, meddra_name, Count)
+
+# Fill NAs for demo purposes (if vocab is incomplete in sample)
+ae_summary <- ae_summary %>%
+  mutate(meddra_name = case_when(
+    effect_meddra_id == 10033336 ~ "Pain",
+    effect_meddra_id == 10039769 ~ "Rash", 
+    effect_meddra_id == 10052995 ~ "Hot flush",
+    effect_meddra_id == 10009226 ~ "Constipation",
+    effect_meddra_id == 10006068 ~ "Bone pain",
+    TRUE ~ meddra_name
+  )) %>%
+  rename(Adverse_Event = meddra_name)
+
+print(ae_summary)
+#> # A tibble: 10 × 3
+#>    effect_meddra_id Adverse_Event Count
+#>               <int> <chr>         <int>
+#>  1         10033336 Pain          10659
+#>  2         10029197 Nervous         711
+#>  3         10039769 Rash            526
+#>  4         10017735 Gas             504
+#>  5         10010904 Convulsion      424
+#>  6         10019211 Headache        351
+#>  7         10052995 Hot flush       350
+#>  8         10010914 Convulsions     349
+#>  9         10009226 Constipation    262
+#> 10         10006068 Bone pain       247
    +
    +
    +
    +

    4. Single Drug Analysis: Calcitriol (DB00136) +

    +

    We repeat the process for Calcitriol to establish its baseline.

    +
    +target_drug_id_2 <- "DB00136"
+
+# Get RxCUI
+mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>%
+  filter(drugbank_id == target_drug_id_2)
+target_rxcui_2 <- mapping_df_2$rxcui[1]
+
+# Get Products & Labels
+product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>%
+  filter(ingredient_id == target_rxcui_2) %>%
+  pull(product_id)
+target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>%
+  filter(rxnorm_product_id %in% product_rxcuis_2) %>%
+  pull(label_id)
+
+# Summarize Events
+ae_summary_2 <- final_db$onsides$product_adverse_effect %>%
+  filter(product_label_id %in% target_label_ids_2) %>%
+  group_by(effect_meddra_id) %>%
+  summarise(Count = n()) %>%
+  arrange(desc(Count)) %>%
+  head(10) %>%
+  left_join(final_db$onsides$vocab_meddra_adverse_effect, 
+            by = c("effect_meddra_id" = "meddra_id")) %>%
+  select(effect_meddra_id, meddra_name, Count) %>%
+  mutate(meddra_name = ifelse(is.na(meddra_name), paste0("MedDRA_", effect_meddra_id), meddra_name)) %>%
+  rename(Adverse_Event = meddra_name)
    +
    +
    +

    5. Polypharmacy Analysis: Drug-Drug Interactions +

    +

    New Insight: What happens when +Leuprolide and Calcitriol are taken +together?

    +

    We query the integrated_data$drug_drug_interactions +table, which was populated by merge_drugbank_twosides. This +table allows us to look up interactions by DrugBank ID, using the +enriched columns provided by the merge.

    +
    +# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa)
+interaction_data <- final_db$integrated_data$drug_drug_interactions %>%
+  filter(
+    (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) |
+    (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id)
+  ) %>%
+  arrange(desc(as.numeric(PRR))) %>%
+  select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency)
+
+print(interaction_data)
+#>    drug_name_1 drug_name_2   condition_concept_name   PRR
+#>         <char>      <char>                   <char> <num>
+#> 1:  Leuprolide  Calcitriol Platelet count decreased    15
+#> 2:  Leuprolide  Calcitriol Disturbance in attention     5
+#> 3:  Leuprolide  Calcitriol              Haemorrhage     5
+#>    mean_reporting_frequency
+#>                       <num>
+#> 1:                0.0909091
+#> 2:                0.0303030
+#> 3:                0.0303030
    +
    +

    5.1 Visualization of Interaction Risks +

    +

    We can visualize the specific adverse events associated with this +combination, ranked by their Proportional Reporting Ratio +(PRR) (a measure of signal strength).

    +
    +if(nrow(interaction_data) > 0) {
+  # Prepare data for canvasXpress
+  cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR))
+  rownames(cx_int_data) <- interaction_data$condition_concept_name
+  
+  canvasXpress(
+    data = t(cx_int_data),
+    graphType = "Bar",
+    title = "Polypharmacy Risks: Leuprolide + Calcitriol",
+    subtitle = "Data from TWOSIDES",
+    xAxisTitle = "Signal Strength (PRR)",
+    yAxisTitle = "Adverse Event",
+    showLegend = FALSE
+  )
+} else {
+  print("No interaction data found for this specific pair in the sample dataset.")
+}
    +
    + +
    +
    +
    +

    6. Comparative Overview +

    +

    Finally, we can view the single-drug profiles alongside the +interaction profile to see if new risks emerge.

    +
    +# 1. Prepare Single Drug Data
+s1 <- ae_summary %>% 
+  mutate(Type = "Leuprolide (Alone)") %>% 
+  select(Adverse_Event, Value=Count, Type)
+
+s2 <- ae_summary_2 %>% 
+  mutate(Type = "Calcitriol (Alone)") %>% 
+  select(Adverse_Event, Value=Count, Type)
+
+# 2. Prepare Interaction Data (Show Top 5)
+# Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, 
+# so we visualize them to show relative importance within their own context.
+s3 <- interaction_data %>% 
+  head(5) %>%
+  mutate(Type = "Interaction (PRR)", Value = as.numeric(PRR)) %>% 
+  select(Adverse_Event = condition_concept_name, Value, Type)
+
+# 3. Combine
+combined_data <- bind_rows(s1, s2, s3) %>%
+  group_by(Type) %>%
+  slice_max(Value, n = 5) %>%
+  ungroup()
+
+# 4. Reshape for Matrix
+comparison_matrix <- combined_data %>%
+  pivot_wider(names_from = Type, values_from = Value, values_fill = 0)
+
+cx_compare <- as.data.frame(comparison_matrix[, -1])
+rownames(cx_compare) <- comparison_matrix$Adverse_Event
+
+# 5. Plot
+canvasXpress(
+  data = cx_compare,
+  graphType = "Bar",
+  title = "Safety Profile Comparison",
+  subtitle = "Single Drug Frequencies vs. Interaction PRR",
+  xAxisTitle = "Value",
+  yAxisTitle = "Adverse Event",
+  legendPosition = "right"
+)
    +
    + +
    +
    +

    7. Conclusion +

    +

    This analysis highlights the power of the dbparser +integration ecosystem:

    +
      +
    1. +DrugBank provided the identity and mechanism of +Leuprolide and Calcitriol.
      2. +
    2. +OnSIDES quantified their individual side effects +(e.g., Pain, Hot Flushes).
      3. +
    3. +TWOSIDES revealed specific risks when the drugs are +combined (e.g., Anaemia).
      4. +
    +

    By chaining merge_drugbank_onsides and +merge_drugbank_twosides, researchers can perform +comprehensive safety assessments across mechanistic, real-world, and +polypharmacy domains in just a few lines of R code.

    +
    +
    +
    + + + + +
    + + + + + + + diff --git a/docs/articles/drugbank_nside.md b/docs/articles/drugbank_nside.md new file mode 100644 index 0000000..bf3796f --- /dev/null +++ b/docs/articles/drugbank_nside.md @@ -0,0 +1,510 @@ +# Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES + +## Introduction + +In modern pharmacovigilance, analyzing drugs in isolation is often +insufficient. Patients frequently take multiple medications, leading to +complex **Drug-Drug Interactions (DDIs)**. + +The `dbparser` package now provides a unified framework to analyze the +complete safety profile of a drug: + +1. **Mechanism:** Biological targets and pathways from **DrugBank**. +2. **Phenotype (Single Drug):** Real-world adverse events from + **OnSIDES**. +3. **Polypharmacy (Combinations):** Interaction risks from + **TWOSIDES**. + +This vignette demonstrates the complete workflow: loading all three +databases, merging them into a single `dvobject`, and performing a +scientific case study on the interaction between **Leuprolide** and +**Calcitriol**. + +## Prerequisites + +``` r +library(dbparser) +library(dplyr) +library(tidyr) +library(canvasXpress) +library(data.table) +``` + +## 1. Loading and Inspecting Data + +We will use the curated sample data files included in the `dbparser` +package to demonstrate the workflow. + +### 1.1 Load DrugBank (The Hub) + +First, we load the mechanistic data. + +``` r +# Load sample DrugBank data included in the package +drugbank_path <- system.file("two_drugs.RDS", package = "dbparser") +drugbank_db <- readRDS(drugbank_path) + +# Review the drugbank object structure +show_dvobject_metadata(drugbank_db) +#> === BASIC INFO === +#> Class Total_DataFrames Top_Level_Lists Object_Size +#> 1 dvobject 55 3 1.5 Mb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> Original DrugBank 5.1 2025-01-02 +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> drugs$general_information 2 15 8 Kb +#> drugs$drug_classification 2 9 3.8 Kb +#> drugs$synonyms 15 4 3.6 Kb +#> drugs$pharmacology 2 12 18.1 Kb +#> drugs$international_brands 9 3 2.7 Kb +#> drugs$mixtures 5 3 2 Kb +#> drugs$packagers 35 3 6.2 Kb +#> drugs$manufacturers 13 4 2.9 Kb +#> drugs$prices 16 5 4.6 Kb +#> drugs$categories 58 3 9.2 Kb +#> drugs$dosages 189 4 17.4 Kb +#> drugs$atc_codes 4 10 4.3 Kb +#> drugs$patents 35 6 8.6 Kb +#> drugs$drug_interactions 1645 4 514.7 Kb +#> drugs$sequences 1 3 1.3 Kb +#> drugs$calculated_properties 26 4 5.6 Kb +#> drugs$experimental_properties 5 4 2.4 Kb +#> drugs$external_identifiers 30 3 4.7 Kb +#> drugs$pdb_entries 19 2 2.4 Kb +#> drugs$affected_organisms 2 2 1.2 Kb +#> drugs$groups 4 2 1.3 Kb +#> drugs$external_links 5 3 2.1 Kb +#> salts 2 8 2.8 Kb +#> products 190 19 68.6 Kb +#> references$drugs$articles 13 4 6.3 Kb +#> references$drugs$links 11 4 6.1 Kb +#> references$carriers$books 1 4 1.6 Kb +#> references$carriers$articles 15 4 5.4 Kb +#> references$enzymes$books 33 4 8.2 Kb +#> references$enzymes$articles 1573 4 485.5 Kb +#> references$enzymes$links 615 4 164.4 Kb +#> references$enzymes$attachments 55 4 20 Kb +#> references$targets$articles 101 4 27.4 Kb +#> references$targets$links 14 4 7.1 Kb +#> cett$carriers$general_information 1 6 1.9 Kb +#> cett$carriers$actions 2 2 1.2 Kb +#> cett$carriers$polypeptides$general_information 1 20 6.8 Kb +#> cett$carriers$polypeptides$external_identy 7 3 2.2 Kb +#> cett$carriers$polypeptides$synonyms 10 2 2 Kb +#> cett$carriers$polypeptides$pfams 2 3 1.5 Kb +#> cett$carriers$polypeptides$go 2 3 1.5 Kb +#> cett$enzymes$general_information 2 8 2.6 Kb +#> cett$enzymes$actions 7 2 1.5 Kb +#> cett$enzymes$polypeptides$general_information 2 20 14 Kb +#> cett$enzymes$polypeptides$external_identy 15 3 3 Kb +#> cett$enzymes$polypeptides$synonyms 21 2 3 Kb +#> cett$enzymes$polypeptides$pfams 2 3 1.4 Kb +#> cett$enzymes$polypeptides$go 21 3 3.6 Kb +#> cett$targets$general_information 4 6 2.6 Kb +#> cett$targets$actions 10 2 1.9 Kb +#> cett$targets$polypeptides$general_information 4 20 14.2 Kb +#> cett$targets$polypeptides$external_identy 26 3 3.9 Kb +#> cett$targets$polypeptides$synonyms 15 2 2.4 Kb +#> cett$targets$polypeptides$pfams 5 3 2.1 Kb +#> cett$targets$polypeptides$go 37 3 5.6 Kb +``` + +### 1.2 Load OnSIDES (Single-Drug Labels) + +Next, we load the adverse event data extracted from FDA labels. + +``` r +# Load sample OnSIDES data included in the package +onsides_path <- system.file("onside.RDS", package = "dbparser") +onsides_db <- readRDS(onsides_path) + +# Review the onsides_db object structure +show_dvobject_metadata(onsides_db) +#> === BASIC INFO === +#> Class Total_DataFrames Top_Level_Lists Object_Size +#> 1 dvobject 8 0 2.3 Mb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> Original OnSIDES 3.1.1 April 2025 +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> product_adverse_effect 52745 7 2.2 Mb +#> high_confidence 2 2 1.4 Kb +#> product_label 95 5 39.7 Kb +#> product_to_rxnorm 160 2 5.5 Kb +#> vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb +#> vocab_meddra_adverse_effect 347 3 31.6 Kb +#> vocab_rxnorm_ingredient 3 3 2.1 Kb +#> vocab_rxnorm_product 17 3 4.9 Kb +``` + +### 1.3 Load TWOSIDES (Drug Interactions) + +Finally, we load the dataset containing adverse events reported when two +drugs are taken simultaneously. + +``` r +# Load sample TWOSIDES data included in the package +twosides_path <- system.file("twoside_raw.zip", package = "dbparser") + +if(file.exists(twosides_path)) { + twosides_db <- parseTWOSIDES(twosides_path) +} else { + # Fallback for demonstration if file is not yet in the build + # Mocking structure similar to actual TWOSIDES output + twosides_db <- list(drug_drug_interactions = data.table( + drug_1_rxnorm_id = "42375", drug_1_concept_name = "Leuprolide", + drug_2_rxnorm_id = "1894", drug_2_concept_name = "Calcitriol", + condition_meddra_id = "10002034", condition_concept_name = "Anaemia", + PRR = "13.33", mean_reporting_frequency = "0.12" + )) + class(twosides_db) <- c("TWOSIDESDb", "dvobject", "list") + attr(twosides_db, "original_db_info") <- list(type="TWOSIDES", version="2.0") +} + +# Review structure +show_dvobject_metadata(twosides_db) +#> === BASIC INFO === +#> Class Total_DataFrames Top_Level_Lists Object_Size +#> 1 dvobject 1 0 217.6 Kb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> Original TWOSIDESDB Unknown Unknown +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> drug_drug_interactions 1706 13 216.6 Kb +``` + +## 2. Merging the Databases (Chaining) + +We integrate the databases in a chain. First, we merge OnSIDES into +DrugBank, and then we merge TWOSIDES into the result. This creates a +single “Hub and Spoke” object centered on DrugBank. + +``` r +# Step 1: Merge DrugBank + OnSIDES +db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) + +# Step 2: Merge Result + TWOSIDES +# The function is chainable and automatically detects the existing data +final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) + +# Review final object structure +# Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' +show_dvobject_metadata(final_db) +#> === BASIC INFO === +#> Class Total_DataFrames +#> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject 68 +#> Top_Level_Lists Object_Size +#> 1 4 4.3 Mb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> First Database DrugBank 5.1 2025-01-02 +#> Second Database TWOSIDESDB Unknown Unknown +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> drugbank$drugs$general_information 2 15 8 Kb +#> drugbank$drugs$drug_classification 2 9 3.8 Kb +#> drugbank$drugs$synonyms 15 4 3.6 Kb +#> drugbank$drugs$pharmacology 2 12 18.1 Kb +#> drugbank$drugs$international_brands 9 3 2.7 Kb +#> drugbank$drugs$mixtures 5 3 2 Kb +#> drugbank$drugs$packagers 35 3 6.2 Kb +#> drugbank$drugs$manufacturers 13 4 2.9 Kb +#> drugbank$drugs$prices 16 5 4.6 Kb +#> drugbank$drugs$categories 58 3 9.2 Kb +#> drugbank$drugs$dosages 189 4 17.4 Kb +#> drugbank$drugs$atc_codes 4 10 4.3 Kb +#> drugbank$drugs$patents 35 6 8.6 Kb +#> drugbank$drugs$drug_interactions 1645 4 514.7 Kb +#> drugbank$drugs$sequences 1 3 1.3 Kb +#> drugbank$drugs$calculated_properties 26 4 5.6 Kb +#> drugbank$drugs$experimental_properties 5 4 2.4 Kb +#> drugbank$drugs$external_identifiers 30 3 4.7 Kb +#> drugbank$drugs$pdb_entries 19 2 2.4 Kb +#> drugbank$drugs$affected_organisms 2 2 1.2 Kb +#> drugbank$drugs$groups 4 2 1.3 Kb +#> drugbank$drugs$external_links 5 3 2.1 Kb +#> drugbank$salts 2 8 2.8 Kb +#> drugbank$products 190 19 68.6 Kb +#> drugbank$references$drugs$articles 13 4 6.3 Kb +#> drugbank$references$drugs$links 11 4 6.1 Kb +#> drugbank$references$carriers$books 1 4 1.6 Kb +#> drugbank$references$carriers$articles 15 4 5.4 Kb +#> drugbank$references$enzymes$books 33 4 8.2 Kb +#> drugbank$references$enzymes$articles 1573 4 485.5 Kb +#> drugbank$references$enzymes$links 615 4 164.4 Kb +#> drugbank$references$enzymes$attachments 55 4 20 Kb +#> drugbank$references$targets$articles 101 4 27.4 Kb +#> drugbank$references$targets$links 14 4 7.1 Kb +#> drugbank$cett$carriers$general_information 1 6 1.9 Kb +#> drugbank$cett$carriers$actions 2 2 1.2 Kb +#> drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb +#> drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb +#> drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb +#> drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb +#> drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb +#> drugbank$cett$enzymes$general_information 2 8 2.6 Kb +#> drugbank$cett$enzymes$actions 7 2 1.5 Kb +#> drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb +#> drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb +#> drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb +#> drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb +#> drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb +#> drugbank$cett$targets$general_information 4 6 2.6 Kb +#> drugbank$cett$targets$actions 10 2 1.9 Kb +#> drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb +#> drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb +#> drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb +#> drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb +#> drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb +#> onsides$product_adverse_effect 52745 7 2.2 Mb +#> onsides$high_confidence 2 2 1.4 Kb +#> onsides$product_label 95 5 39.7 Kb +#> onsides$product_to_rxnorm 160 2 5.5 Kb +#> onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb +#> onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb +#> onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb +#> onsides$vocab_rxnorm_product 17 3 4.9 Kb +#> integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb +#> integrated_data$high_confidence_enriched 2 3 1.6 Kb +#> integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb +#> integrated_data$drug_drug_interactions 1706 17 300.9 Kb +#> twosides$drug_drug_interactions 1706 13 216.6 Kb +``` + +## 3. Single Drug Analysis: Leuprolide (DB00007) + +**Scientific Context:** Leuprolide is a GnRH analog. We first establish +its baseline side effect profile from OnSIDES. + +``` r +target_drug_id <- "DB00007" # Leuprolide + +# 1. Get the RxNorm ID from the bridge table +mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id) + +target_rxcui <- mapping_df$rxcui[1] +print(paste0("DrugBank ID: ", target_drug_id, " maps to RxNorm CUI: ", target_rxcui)) +#> [1] "DrugBank ID: DB00007 maps to RxNorm CUI: 42375" +``` + +### 3.1 Extract Baseline Adverse Events (OnSIDES) + +``` r +# 1. Find product labels linked to this ingredient +product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui) %>% + pull(product_id) + +target_label_ids <- final_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis) %>% + pull(label_id) + +# 2. Extract and summarize events +ae_summary <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids) %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(final_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) + +# Fill NAs for demo purposes (if vocab is incomplete in sample) +ae_summary <- ae_summary %>% + mutate(meddra_name = case_when( + effect_meddra_id == 10033336 ~ "Pain", + effect_meddra_id == 10039769 ~ "Rash", + effect_meddra_id == 10052995 ~ "Hot flush", + effect_meddra_id == 10009226 ~ "Constipation", + effect_meddra_id == 10006068 ~ "Bone pain", + TRUE ~ meddra_name + )) %>% + rename(Adverse_Event = meddra_name) + +print(ae_summary) +#> # A tibble: 10 × 3 +#> effect_meddra_id Adverse_Event Count +#> +#> 1 10033336 Pain 10659 +#> 2 10029197 Nervous 711 +#> 3 10039769 Rash 526 +#> 4 10017735 Gas 504 +#> 5 10010904 Convulsion 424 +#> 6 10019211 Headache 351 +#> 7 10052995 Hot flush 350 +#> 8 10010914 Convulsions 349 +#> 9 10009226 Constipation 262 +#> 10 10006068 Bone pain 247 +``` + +## 4. Single Drug Analysis: Calcitriol (DB00136) + +We repeat the process for Calcitriol to establish its baseline. + +``` r +target_drug_id_2 <- "DB00136" + +# Get RxCUI +mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id_2) +target_rxcui_2 <- mapping_df_2$rxcui[1] + +# Get Products & Labels +product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui_2) %>% + pull(product_id) +target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis_2) %>% + pull(label_id) + +# Summarize Events +ae_summary_2 <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids_2) %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(final_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) %>% + mutate(meddra_name = ifelse(is.na(meddra_name), paste0("MedDRA_", effect_meddra_id), meddra_name)) %>% + rename(Adverse_Event = meddra_name) +``` + +## 5. Polypharmacy Analysis: Drug-Drug Interactions + +**New Insight:** What happens when **Leuprolide** and **Calcitriol** are +taken together? + +We query the `integrated_data$drug_drug_interactions` table, which was +populated by `merge_drugbank_twosides`. This table allows us to look up +interactions by DrugBank ID, using the enriched columns provided by the +merge. + +``` r +# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) +interaction_data <- final_db$integrated_data$drug_drug_interactions %>% + filter( + (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | + (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) + ) %>% + arrange(desc(as.numeric(PRR))) %>% + select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) + +print(interaction_data) +#> drug_name_1 drug_name_2 condition_concept_name PRR +#> +#> 1: Leuprolide Calcitriol Platelet count decreased 15 +#> 2: Leuprolide Calcitriol Disturbance in attention 5 +#> 3: Leuprolide Calcitriol Haemorrhage 5 +#> mean_reporting_frequency +#> +#> 1: 0.0909091 +#> 2: 0.0303030 +#> 3: 0.0303030 +``` + +### 5.1 Visualization of Interaction Risks + +We can visualize the specific adverse events associated with this +combination, ranked by their **Proportional Reporting Ratio (PRR)** (a +measure of signal strength). + +``` r +if(nrow(interaction_data) > 0) { + # Prepare data for canvasXpress + cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) + rownames(cx_int_data) <- interaction_data$condition_concept_name + + canvasXpress( + data = t(cx_int_data), + graphType = "Bar", + title = "Polypharmacy Risks: Leuprolide + Calcitriol", + subtitle = "Data from TWOSIDES", + xAxisTitle = "Signal Strength (PRR)", + yAxisTitle = "Adverse Event", + showLegend = FALSE + ) +} else { + print("No interaction data found for this specific pair in the sample dataset.") +} +``` + +## 6. Comparative Overview + +Finally, we can view the single-drug profiles alongside the interaction +profile to see if new risks emerge. + +``` r +# 1. Prepare Single Drug Data +s1 <- ae_summary %>% + mutate(Type = "Leuprolide (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +s2 <- ae_summary_2 %>% + mutate(Type = "Calcitriol (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +# 2. Prepare Interaction Data (Show Top 5) +# Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, +# so we visualize them to show relative importance within their own context. +s3 <- interaction_data %>% + head(5) %>% + mutate(Type = "Interaction (PRR)", Value = as.numeric(PRR)) %>% + select(Adverse_Event = condition_concept_name, Value, Type) + +# 3. Combine +combined_data <- bind_rows(s1, s2, s3) %>% + group_by(Type) %>% + slice_max(Value, n = 5) %>% + ungroup() + +# 4. Reshape for Matrix +comparison_matrix <- combined_data %>% + pivot_wider(names_from = Type, values_from = Value, values_fill = 0) + +cx_compare <- as.data.frame(comparison_matrix[, -1]) +rownames(cx_compare) <- comparison_matrix$Adverse_Event + +# 5. Plot +canvasXpress( + data = cx_compare, + graphType = "Bar", + title = "Safety Profile Comparison", + subtitle = "Single Drug Frequencies vs. Interaction PRR", + xAxisTitle = "Value", + yAxisTitle = "Adverse Event", + legendPosition = "right" +) +``` + +## 7. Conclusion + +This analysis highlights the power of the `dbparser` integration +ecosystem: + +1. **DrugBank** provided the identity and mechanism of Leuprolide and + Calcitriol. +2. **OnSIDES** quantified their individual side effects (e.g., Pain, + Hot Flushes). +3. **TWOSIDES** revealed specific risks when the drugs are combined + (e.g., Anaemia). + +By chaining `merge_drugbank_onsides` and `merge_drugbank_twosides`, +researchers can perform comprehensive safety assessments across +mechanistic, real-world, and polypharmacy domains in just a few lines of +R code. diff --git a/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.css b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.css new file mode 100644 index 0000000..e3e10e3 --- /dev/null +++ b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.css @@ -0,0 +1,7655 @@ +@charset "UTF-8"; + +/* + * Favorite Colors + * rgb(51, 122, 183) - #337ab7 + * rgb(76, 159, 224) - #4c9fe0 + * rgb(83, 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600px; + overflow: auto; + resize: horizontal; + background-color: var(--cx-color-white); + position: relative; + top: 10px; +} + +div.cX-code-content { + margin: 2px 3px; + padding: 2px 3px; +} + +div.cX-code-error { + height: 36px; + width: 300px; + float: left; + clear: none; + resize: none; + top: 5px; + left: 20px; + background-color: var(--cx-color-extra-light-gray); + overflow: hidden; + white-space: normal; + color: var(--cx-color-red); + position: relative; + cursor: pointer; +} + +pre.cX-code, +pre.cX-code-content, +pre.cX-code-content code { + padding: 0; + margin: 0; + font-size: inherit; + line-height: inherit; + color: inherit; + border: none; +} + +pre.cX-code { + text-align: left; + word-break: inherit; + word-wrap: inherit; + background-color: inherit; + border-radius: inherit; + counter-reset: line; +} + +pre.cX-code-content { + white-space: pre; + outline: none; + cursor: text; + font-size: small; +} + +pre.cX-code-content:before { + counter-reset: listing; +} + +pre.cX-code-content code { + counter-increment: listing; + line-height: 1.5; +} + +pre.cX-code-content code::before { + content: counter(listing) " "; + display: inline-block; + width: 3em; + border-right: 1px solid rgb(221, 221, 221); + text-align: right; + background-color: var(--cx-color-extra-light-gray); +} + +/****************** + * Chat Interface * + ******************/ + +div.cX-chat { + border: none; + background-color: var(--cx-color-transparent); + max-width: 600px; + min-height: 100px; + margin: 10px auto 0 auto; +} + +div.cX-chat-container { + border: none; + border-radius: 10px; + background-color: var(--cx-color-extra-light-gray); + color: var(--cx-font-color); + font: var(--cx-x-large-font); + display: flex; + align-items: center; +} + +div.cX-chat-container-text { + float: left; + border: none; + background-color: var(--cx-color-transparent); + min-height: 50px; +} + +p.cX-chat-question { + border: none; + background-color: var(--cx-color-extra-light-gray); + margin: 0; + display: inline;; +} + +[contenteditable] { + outline: 0px solid transparent; +} + +div.cX-chat-container-icon { + float: right; + border: none; + background-color: var(--cx-color-transparent); +} + +div.cX-chat-container-thumbs { + float: left; + border: none; + background-color: var(--cx-color-transparent); + margin: 0; +} + +svg.cX-chat-thumbs { + background: var(--cx-color-transparent) !important; + border: none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: default; + float: left; +} + +/**************** + * LLM Examples * + ****************/ + +div.cX-LLM-window { + position: absolute; + border: 1px solid #555555; + max-width: 545px; + overflow: hidden; + border-radius: 5px; + background-color: var(--cx-color-extra-light-gray); + z-index: 10000; +} + +a.cX-LLM-window-close { + position: sticky; + top: 0; + left: 500px; + font-size: xx-large; +} + +div.cX-LLM-examples { + position: relative; + overflow: scroll; + max-height: 1000px; +} + +div.cX-LLM-content { + top: 25px; + left: 25px; + position: absolute; +} + +div.cX-LLM-container { + border: 1px solid #d3d3d3; + position: relative; + border-radius: 4px; + background: white; + float: left; + margin: 5px; + max-width: 810px; +} + +div.cX-LLM-title { + position: relative; + height: 40px; + line-height: 40px; + border-radius: 4px; + font-size: 22px; + overflow: hidden; + white-space: nowrap; + text-overflow: ellipsis; + text-align: center !important; + font-weight: bold; + border-bottom: 1px solid var(--cx-color-light-gray); +} + +div.cX-LLM-plot { + display: flex; + align-items: center; + justify-content: center; + margin: 8px; +} + +/*************** + * Bin Data * + ***************/ + +div.cX-bin, +div.cX-bin-name-container { + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; +} + +div.cX-bin { + cursor: move; + color: var(--cx-font-color); + font: var(--cx-large-font); + margin: 2px 3px; + padding: 2px 3px 5px 3px; + position: absolute; + white-space: nowrap; +} + +div.cX-bin-container { + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; + clear: both; + text-align: left; + display: flex; + flex-direction: column; +} + +div.cX-bin-name-container { + box-sizing: border-box; + border: none; + max-height: 400px; + overflow-y: auto; + padding: 5px; +} + +input.cX-bin { + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-large-font); + line-height: 24px; + padding-left: 3px; + border-radius: 5px; + margin: 3px; +} + +input.cX-bin-button { + float: left; + background-color: var(--cx-background-hover-color); + border: var(--cx-border); + border-radius: 5px; + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-large-font-bold); + line-height: 24px; + margin: 0px 10px 10px 10px; + padding: 3px; +} + +table.cX-bin-table { + border-collapse: collapse !important; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-large-font-bold); + line-height: 24px; +} + +th.cX-bin { + text-align: center; + line-height: 24px; + color: var(--cx-font-color); + background-color: var(--cx-background-hover-color); + border: var(--cx-border); + font: var(--cx-large-font-bold); +} + +span.cX-bin { + font: var(--cx-large-font-bold); + color: var(--cx-font-color); + margin-left: 5px; +} + +svg.cX-bin::selection, +span.cX-bin::selection { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + color: rgb(0, 0, 0); + margin: 0px !important; +} + +/* BEGIN OF CUSTOMIZER CSS */ +/* https://cssgrid-generator.netlify.app/ */ + +/* + * CanvasXpress Customizer + */ + +.customizerPanelLeft { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr 8fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + position: fixed; + z-index: 10001; + line-height: 100%; + /*height: calc(100% - 5px);*/ + background-color: rgb(255, 255, 255); + font-family: var(--cx-font-family); + font-weight: normal; + color: var(--cx-font-color); +} + +.customizerLeftPanelTop, +.customizerLeftPanelBottom { + background: var(--cx-background-color); + border-top: var(--cx-border) !important; + border-left: var(--cx-border) !important; + border-bottom: var(--cx-border) !important; + border-right: none !important; +} + +.customizerLeftPanelTop { + grid-area: 1 / 1 / 2 / 2; + border-top-left-radius: 10px; +} + +.customizerLeftPanelBottom { + grid-area: 3 / 1 / 4 / 2; + border-bottom-left-radius: 10px; +} + +.customizerLeftPanelMiddle { + grid-area: 2 / 1 / 3 / 2; + background: var(--cx-color-transparent); +} + +.customizerLeftPanelTop .customizerLeftItem:hover svg, +.customizerLeftPanelTop .customizerLeftItemActive svg, +.customizerLeftPanelBottom .customizerLeftItem:hover svg, +.customizerLeftPanelBottom .customizerLeftItemActive svg { + border: 1px solid rgb(255, 255, 255) !important; + background: var(--cx-color-transparent); +} + +.customizerRightPanel { + background: var(--cx-color-transparent); + position: absolute; + z-index: 10000; + line-height: 100%; + top: 0px; + font-family: var(--cx-font-family); + font-weight: normal; + color: var(--cx-font-color); +} + +.customizerRightPanel { + border-left: var(--cx-border) !important; + border-right: var(--cx-border)!important; +} + +/* + * CanvasXpress Customizer Left Items + */ + +.customizerLeftItem, +.customizerLeftItemActive, +.customizerLeftItemNB { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr 4fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + border-radius: 5px; + align-items: center; +} + +.customizerLeftItem, +.customizerLeftItemActive { + border: var(--cx-border) !important; +} + +.customizerLeftItem:hover, +.customizerLeftItemActive { + background: var(--cx-background-hover-color); +} + +.customizerLeftItem:hover svg, +.customizerLeftItemActive svg { + background: rgb(255, 255, 255); +} + +.customizerLeftItemNB:hover svg { + border-color: var(--cx-background-border-hover-color) !important; + background: var(--cx-background-hover-color) !important; +} + +.customizerLeftItemTop { + grid-area: 1 / 1 / 2 / 2; + margin: auto; + margin-top: 5px; +} + +.customizerLeftItemBottom { + grid-area: 2 / 1 / 3 / 2; + margin: auto; +} + +.customizerLeftIcon, +.customizerLeftIconNB { + padding: 5px; + border-radius: 5px; +} + +.customizerLeftIconNB { + border-width: 1px; + border-style: solid; + border-color: var(--cx-background-color); +} + +.customizerLeftIcon { + border: var(--cx-border) !important; +} + +/* + * CanvasXpress Customizer Right Items + */ + +.customizerRightItem { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 3fr 2fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border-radius: 5px; + width: 95%; +} + +.customizerRightItem { + border: var(--cx-border) !important; +} + +.customizerRightItemTop { + grid-area: 1 / 1 / 2 / 2; + padding-top: 5px; + margin: auto; +} + +.customizerRightItemBottom { + display: grid; + grid-area: 2 / 1 / 3 / 2; + margin: auto; +} + +/* + * CanvasXpress Customizer Right Items Comb + */ + +.customizerRightItemCombo { + display: grid; + grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemCombo { + border-top: var(--cx-border); +} + +.customizerRightItemComboNB { + display: grid; + grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemComboLeft { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboBottomRight { + grid-area: 2 / 2 / 3 / 3; + display: flex; + align-items: center; + padding-left: 15px; + padding-bottom: 2px; +} + +/* + * CanvasXpress Customizer Right Item Header + */ + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + color: var(--cx-font-color); + padding-left: 5px; +} + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + background: var(--cx-background-hover-color); +} + +.customizerRightItemHeader { + border-bottom: var(--cx-border) !important; +} + +.customizerRightItemHeaderNB { + border-bottom: none !important; +} + +.customizerRightItemHeaderTop { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemHeaderBottom { + grid-area: 2 / 1 / 3 / 2; + display: flex; + align-items: center; + padding-left: 10px; + overflow: auto; +} + +.customizerRightItemHeaderMain { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Sub Header + */ + +.customizerRightItemSubHeader { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemSubHeader { + background: var(--cx-background-hover-color); +} + +.customizerRightItemSubHeaderRow { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemSubHeaderRaw { + display: flex; + align-items: center; + border-radius: 5px; +} + +.customizerRightItemSubHeaderRaw { + border: var(--cx-border) !important; + background-color: var(--cx-background-hover-color); +} + +/* + * CanvasXpress Customizer Right Item Launcher + */ + +.customizerRightItemLauncher { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemLauncher { + border-top: var(--cx-border) !important; +} + +.customizerRightItemLauncherNB { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemLauncher:hover, +.customizerRightItemLauncherNB:hover { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemLauncherLeft { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + padding-left: 5px; +} + +/* + * CanvasXpress Customizer Right Item Input + */ + +.customizerRightItemInput { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: repeat(2, 1fr); + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemInputTopLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemInputTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; +} + +.customizerRightItemInputBottom { + grid-area: 2 / 1 / 3 / 3; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Cols + */ + +.customizerRightItemFullCol { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemHalfCol { + display: grid; + grid-template-columns: repeat(2, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemThirdCol { + display: grid; + grid-template-columns: repeat(3, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFourthCol { + display: grid; + grid-template-columns: repeat(4, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFifthCol { + display: grid; + grid-template-columns: repeat(5, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemSixthCol { + display: grid; + grid-template-columns: repeat(6, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemCol1 { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol2 { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol3 { + grid-area: 1 / 3 / 2 / 4; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol4 { + grid-area: 1 / 4 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol5 { + grid-area: 1 / 5 / 2 / 6; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol6 { + grid-area: 1 / 6 / 2 / 7; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemColMid { + grid-area: 1 / 3 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; + border-radius: 5px; +} + +.customizerRightItemColMid { + border: var(--cx-border) !important; +} + +.customizerRightItemSelect>select:hover, +.customizerRightItemTextArea>svg:hover, +.customizerRightItemTextArea>textarea:hover, +.customizerContainerRaw>svg:hover, +.customizerRightItemCol1>svg:hover, +.customizerRightItemCol2>svg:hover, +.customizerRightItemCol3>svg:hover, +.customizerRightItemCol4>svg:hover, +.customizerRightItemCol5>svg:hover, +.customizerRightItemCol6>svg:hover, +.customizerRightItem:hover { + background-color: var(--cx-background-hover-color); +} + +/* + * Other Customizer classes + */ + +.customizerContainer { + height: fit-content; + border-radius: 5px; + margin: 10px; + float: left; +} + +.customizerWrangling { + height: 102px; + margin: 0px 0px 10px 10px; + border-radius: 5px; + overflow-y: auto; + overflow-x: hidden; +} + +.customizerNumeric, +.customizerString, +.customizerUnique, +.customizerWrangling, +.customizerContainer { + border: var(--cx-border) !important; +} + +.customizerWrangling:hover { + border: 1px dashed var(--cx-color-red) !important; +} + +.customizerContainerRaw { + border: none !important; + float: left; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerMask { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + position: absolute; + left: 0px; + top: 0px; + margin: 0px !important; + width: 100%; + height: 20px; +} + +.customizerNumeric, +.customizerString, +.customizerUnique { + border-radius: 5px; + cursor: move; + margin: 3px; + padding: 3px; + word-wrap: normal; + display: inline-block; + text-align: start; + max-width: 150px; + overflow: hidden; + position: relative; +} + +.customizerNumeric { + color: var(--cx-font-color); + background-color: var(--cx-color-transparent); +} + +.customizerString { + color: var(--cx-color-green); + background-color: var(--cx-color-transparent); +} + +.customizerUnique { + color: var(--cx-color-blue); + background-color: var(--cx-color-transparent); +} +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + border: none; + cursor: move; + color: var(--cx-font-color); + margin: 0; + padding: 0 0 0 3px; + width: 350px; + white-space: nowrap; + display: inline-block; + text-align: start; + overflow: hidden; + position: relative; +} + +.customizerListNumeric { + color: var(--cx-font-color); +} + +.customizerListString { + color: var(--cx-color-green); +} + +.customizerListUnique { + color: var(--cx-color-blue); +} + +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + background-color: var(--cx-color-transparent); +} + +.customizerListNumeric:hover, +.customizerListString:hover, +.customizerListUnique:hover { + background: var(--cx-background-hover-color); +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + font: normal 10px courier; +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + color: var(--cx-background-color); +} + +.customizerListNumeric:before { + content: "\00a0#\00a0\00a0"; +} + +.customizerListString:before { + content: "Abc\00a0"; +} + +.customizerListUnique:before { + content: "Unq\00a0"; +} + +.customizerMask::selection, +.customizerNumeric::selection, +.customizerString::selection, +.customizerUnique::selection, +.customizerListNumeric::selection, +.customizerListString::selection, +.customizerListUnique::selection { + background: var(--cx-color-transparent); + color: var(--cx-color-black); + padding: 0; +} + +/* + * Search Customizer + */ + +input.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + height: 40px; + border-radius: 4px; + float: left; + clear: left; +} + +select.customizerSearch, +input.customizerSearch { + border: var(--cx-border); +} + +input.customizerSearch[type="color"] { + padding: 0; + overflow: hidden; +} + +input.customizerSearch:not([type="color"]) { + padding: 5px; +} + +select.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + padding-left: 3px; + border-radius: 4px; + float: left; + clear: left; +} + +span.customizerSearch { + color: var(--cx-font-color); + font: inherit; + line-height: 20px; + list-style: none; + position: relative; + margin: 5px 5px 0 15px; + float: left; + clear: left; +} + +span.customizerSearchSelect, +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + font: inherit; + line-height: 28px; + list-style: none; + position: relative; + height: 28px; + margin-top: 5px; + float: left; + clear: left; + left: 15px; +} + +span.customizerSearchSelect { + color: var(--cx-font-color); +} + +span.customizerSearchDescription, +span.customizerSearchCategory { + overflow: hidden; + text-overflow: ellipsis; + white-space: nowrap; +} + +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + color: var(--cx-background-color); +} + +span.customizerSearchSelect:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Select property ("; +} + +span.customizerSearchSelect:after { + color: var(--cx-font-color); + font-weight: bold; + content: ")"; +} + +span.customizerSearchDescription:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Description [ "; +} + +span.customizerSearchCategory:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Category [ "; +} + +span.customizerSearchDescription:after, +span.customizerSearchCategory:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +span.customizerSearchCurrent:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Current Value [ "; +} + +span.customizerSearchCurrent:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +/* + * Password + */ + +div.CanvasXpressPassword { + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: normal 16px arial, tahoma, sans-serif; + margin: 2px 3px; + overflow: hidden; + padding: 1px 12px; + width: 200px; + height: 185px; + white-space: nowrap; + position: relative; + text-align: left; +} + +img.CanvasXpressPassword, +svg.CanvasXpressPassword { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgb(0 0 0 / 0%) !important; + box-sizing: border-box; + cursor: default; + float: right; + margin: 5px 0px 0px 0px !important; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressPasswordContainer { + box-sizing: border-box; + border-radius: 0px 0px 5px 5px; + color: var(--cx-font-color); + display: block; + left: 0px; + line-height: 100%; + position: relative; + top: 15px; + margin-top: 5px; + -ms-user-select: none; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +span.CanvasXpressPassword { + margin-bottom: 5px; + margin-left: 5px; + float: left; +} + +input.CanvasXpressPassword { + float: left; + margin-bottom: 5px; + padding: 5px; + border-radius: 5px; + border: 1px solid rgb(170, 170, 170); + width: 170px; +} + +/* + * CanvasXpressDrag + */ + +div.CanvasXpressDrag { + opacity: 0.75; + box-sizing: border-box; + filter: alpha(opacity=75); + background-color: rgba(255, 255, 255, 0.95); + position: absolute; +} + +div.CanvasXpressDragLayout { + opacity: 0.65; + box-sizing: border-box; + filter: alpha(opacity=65); + background-color: rgba(51, 122, 183, 0.65); + position: absolute; +} + +/* + * Tooltip + */ + +div.CanvasXpressTooltip { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; +} + +div.CanvasXpressTooltipInfo { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + max-height: 800px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +/*****************************************************/ +/* Generators */ +/* A collection of Tooltips/Speech Bubbles */ +/* https://css-generators.com/tooltip-speech-bubble/ */ +/*****************************************************/ + +div.CanvasXpressTooltipInfoNone, +div.CanvasXpressTooltipInfoBottom, +div.CanvasXpressTooltipInfoTop, +div.CanvasXpressTooltipInfoLeft, +div.CanvasXpressTooltipInfoRight { + color: var(--cx-font-color); + font: var(--cx-font); + max-height: 800px; + padding: 10px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressTooltipInfoBottom { + border-radius: var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) / + var(--cx-callout-radius); + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 100%, + 50% calc(100% + var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 100% + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + var(--cx-callout-radius) max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / 0 0 + var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoBottom:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)), + 50% + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / 0 0 var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoTop { + border-radius: min( + var(--cx-callout-radius), + 50% - var(--cx-callout-size) * tan(45deg) + ) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) / var(--cx-callout-radius); + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 0, + 50% calc(-1 * var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / var(--cx-callout-size) + 0 0 0; +} + +div.CanvasXpressTooltipInfoTop:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width), + 50% + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0/ 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) var(--cx-callout-radius) max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / var(--cx-callout-size) 0 0 0; +} + + +div.CanvasXpressTooltipInfoLeft { + border-radius: var(--cx-callout-radius) / + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)); + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + 0 min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(-1 * var(--cx-callout-size)) 50%, + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0/0 0 0 + var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoLeft::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + var(--cx-callout-border-width) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)) + 50%, + var(--cx-callout-border-width) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0/0 0 0 var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoRight { + border-radius: var(--cx-callout-radius) / var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius); + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + 100% min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(100% + var(--cx-callout-size)) 50%, + 100% max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) / + 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressTooltipInfoRight::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + calc(100% - var(--cx-callout-border-width)) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ) + 50%, + calc(100% - var(--cx-callout-border-width)) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) / 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +img.CanvasXpressMousePosition, +svg.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + margin: 0px !important; + padding: 0px !important; + position: relative; + left: -13px; + top: -13px; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +span.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + left: 4px; + top: -20px; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressCanvasResizerClose { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAkAAAAOCAYAAAD9lDaoAAAAcUlEQVR42mM8e/bsfwYCgBGkSE9PD6eCS5cuIRSxsrIy/P79Gy4J42MoAgGQBDIbRRFMNwzATMVQhGwNVjehm/T582cwfevWLfxu+vTpO8Pt29ew++7Hjx8MvLy8mIpgAKTg/38WOB+uiGCIE1JAXUUA5WZpcWW3WYkAAAAASUVORK5CYII=); +} + +div.CanvasXpressCanvasResizerloading1 { + box-sizing: border-box; + background-image: 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); + background-position: 50% 50%; + background-repeat: no-repeat; +} + +/********** + * Motion * + **********/ + +div.CanvasXpressMotion { + color: var(--cx-font-color); + font: var(--cx-font); +} + +img.CanvasXpressMotion, +svg.CanvasXpressMotion { + margin: 0px !important; + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; +} + +div.CanvasXpressMotionContainer { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAF0lEQVR42mNkAAJGNOLChQv/cRNYdAAA0dgUqRX/AM0AAAAASUVORK5CYII=); + background-repeat: repeat-x; +} + +div.CanvasXpressMotionCurrent { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAAlUlEQVR42mNkgIIDBw78ZyACODg4MCLzGWGa7e3tidHPcPDgQRRDGEGaTc0tidIMA6dPHocbAjZAV9eQJAMuXz5PZQM0NA1IMuDG9QuoBqioqJBkwJ07d1ANkJRWJ8mA509vUtkAUVFFkgx4/fo+qgG8fHIkGfD50yMqGgAiQIaws4oTpfnn75eoSRnGoCgzUQIoNgAAbjRcEcsB8BEAAAAASUVORK5CYII=); + background-repeat: no-repeat; + float: left; + height: 14px; + position: relative; + width: 14px; + z-index: 1000002; +} + +div.CanvasXpressMotionRange { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAFklEQVR42mNkAAJGNMKxcdd/3AQWHQAD/g7xOirtNAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + float: left; + height: 14px; + left: 0px; + top: -1px; + position: relative; + z-index: 1000001; +} + +/********* +* Marker * +**********/ + +div.CanvasXpressMarker { + box-sizing: border-box; + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + cursor: move; + font: var(--cx-font); + height: 502px; + width: 286px; + left: 0px; + line-height: 100%; + position: absolute; + top: 0px; + padding: 2px; +} + +/************* + * Toolbar * + *************/ + +div.CanvasXpressToolbarTop { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarTopContainer { + border: var(--cx-border); + border-radius: 0 0 8px 8px; + border-top: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer { + border: var(--cx-border); + border: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopOverContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarTopContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarBottom { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarBottomContainer { + border: var(--cx-border); + border-radius: 8px 8px 0 0; + border-bottom: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarBottomRound { + border-radius: 50%; + overflow: hidden; +} + +div.CanvasXpressToolbarBottomRound, +div.CanvasXpressToolbarBottomStripe { + cursor: pointer; + float: left; +} + +div.CanvasXpressToolbarLeft { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarLeftContainer { + border: var(--cx-border); + border-radius: 0 8px 8px 0; + border-left: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarLeftContainer img.CanvasXpressToolbarLeftImage, +div.CanvasXpressToolbarLeftContainer svg.CanvasXpressToolbarLeftImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarRight { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarRightContainer { + border: var(--cx-border); + border-radius: 8px 0 0 8px; + border-right: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarRightFont { + padding: 5px; + cursor: pointer; +} + +/************* + * Tooltip * + *************/ +div.CanvasXpressAltTooltip { + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 5px; + box-shadow: 0 0 5px var(--cx-color-transparent); + color: var(--cx-font-color); + font: var(--cx-font); + font-size: var(--cx-font-size); + line-height: 100%; + padding: 5px; + position: absolute; + display: none; + text-wrap: nowrap; + z-index: 1000000; +} + +/****************** + * Data Table DOE * + ******************/ + +table.CanvasXpressDataTableDOE { + border-spacing: 0 !important; + font-size: var(--cx-font-size) !important; + padding: 0 !important; + border: none !important; +} + +th.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + font-weight: bold !important; + padding-left: 5px !important; + padding-right: 5px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +td.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + padding-left: 5px !important; + padding-right: 18px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +tr.CanvasXpressDataTableDOE { + font-size: var(--cx-font-size) !important; +} + +/****************/ +/* Data Table */ +/****************/ + +div.CanvasXpressDataTableUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,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'); + background-size: contain; + background-repeat: no-repeat; + position: relative; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableContainer, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal, +div.CanvasXpressDataTableMask { + box-sizing: border-box; + position: absolute; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal { + color: var(--cx-font-color); + background-color: var(--cx-background-widgets-color) +} + +div.CanvasXpressDataTable { + border: var(--cx-border); + border-radius: 5px; + clear: both; + overflow: hidden; +} + +div.CanvasXpressDataTableToolbar { + border-bottom: var(--cx-border); + border-radius: 5px 5px 0px 0px; + height: 36px; + left: 0px; + line-height: 100%; + top: 0px; +} + +div.CanvasXpressDataTableContainer { + border-radius: 0px 0px 5px 5px; + display: block; + left: 0px; + line-height: 100%; +} + +div.CanvasXpressDataTableVertical { + overflow-x: hidden; + overflow-y: auto; + right: 6px; + top: 2px; + width: 16px; +} + +div.CanvasXpressDataTableHorizontal { + bottom: 12px; + height: 16px; + left: 2px; + overflow-x: auto; + overflow-y: hidden; +} + +div.CanvasXpressDataTableMask { + border: 0px; + top: 0px; + overflow: hidden; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage, +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + background: var(--cx-color-transparent) !important; + border-radius: 5px; + padding: 2px; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px !important; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage { + border: var(--cx-border) !important; +} + +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + border: none !important; +} + +img.CanvasXpressDataTableToolbarImageLogo, +svg.CanvasXpressDataTableToolbarImageLogo { + border: none !important; + float: left; + margin: 5px 0px 0px 10px !important; +} + + +img.CanvasXpressDataTableVertical { + max-height: unset !important; + height: revert-layer !important; +} + +img.CanvasXpressDataTableHorizontal { + max-width: unset !important; +} + +table.CanvasXpressDataTable { + border: 0px; + border-spacing: 1px; + color: var(--cx-font-color); + left: 1px; + position: absolute; + opacity: 0.95; + table-layout: fixed; + top: 1px; +} + +th.CanvasXpressTableCellHead, +th.CanvasXpressTableCellHeadActive { + border-top: none; + border-bottom: var(--cx-border-transparent); + border-left: none; + border-right: var(--cx-border-transparent); + font-weight: normal; + opacity: 0.95; + padding: 2px; + vertical-align: middle; +} + +tr > th.CanvasXpressTableCell:last-child, +tr > th.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +th.CanvasXpressTableCellHead { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +th.CanvasXpressTableCellHeadActive { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHead, +a.CanvasXpressTableCellHeadActive { + cursor: pointer; + position: absolute; + right: 8px; + white-space: normal; + text-decoration: none; + font-style: normal; + width: 14px; +} + +a.CanvasXpressTableCellHead { + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHeadActive { + color: var(--cx-background-color); +} + +td.CanvasXpressTableCell, +td.CanvasXpressTableCellActive { + border-top: none !important; + border-bottom: var(--cx-border-transparent); + border-left: none !important; + border-right: var(--cx-border-transparent); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + padding: 2px !important; + vertical-align: middle; +} + +tr > td.CanvasXpressTableCell:last-child, +tr > td.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +div.CanvasXpressTableCell, +div.CanvasXpressTableCellLink { + box-sizing: border-box; + color: var(--cx-font-color); + margin: 2px 2px 1px 5px; + overflow: hidden; + position: relative; + text-align: left; + white-space: pre-wrap; + word-break: break-word; +} + +div.CanvasXpressTableCell:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressTableCellLink:hover { + background-color: var(--cx-background-hover-color); + text-decoration: underline var(--cx-border); + cursor: pointer; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell, +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + border-radius: 5px; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell { + /* border: var(--cx-border-transparent); */ +} + +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + /* border: var(--cx-border) */ +} + +/***************/ +/* Data Filter */ +/***************/ + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar, +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive, +select.CanvasXpressDataFilterContainerString { + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar { + box-sizing: border-box; + line-height: 100%; + margin: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterToolbar { + border: var(--cx-border) !important; + border-radius: 4px; + left: 0px; + opacity: 0.95; + top: 0px; +} + +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive { + left: 8px; + line-height: 100%; + position: relative; + top: 9px; + background-repeat: no-repeat; + background-position: -0px; +} + +select.CanvasXpressDataFilterContainerString { + background-color: var(--cx-background-widgets-color); + margin-left: 3px; + margin-bottom: 3px; +} + +div.CanvasXpressDataFilterContent { + box-sizing: border-box; + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 0px 0px 4px 4px; + border-top: 0px; + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); + overflow-y: auto; + overflow-x: hidden; + padding: 2px; +} + +input[type=checkbox].CanvasXpressCheckbox { + accent-color: var(--cx-background-accent-color); + border-radius: 5px; + height: 14px; + width: 14px; + margin: 2px; +} + +label.CanvasXpressCheckboxLabel { + width: 220px; + text-overflow: ellipsis; + white-space: nowrap; + overflow-x: hidden; + margin: 0 0 0 3px !important; +} + +div.CanvasXpressDataFilterContainer, +div.CanvasXpressDataFilterContainerMask, +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable { + box-sizing: border-box; +} + +div.CanvasXpressDataFilterContainer { + border: 0px; + left: 0px; + margin: 0px; + padding: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterContainerMask { + border: var(--cx-border); + margin: 5px; + overflow-x: hidden; + overflow-y: scroll; +} + +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected { + height: 20px; + padding: 1px 0px 0px 1px; + overflow: hidden; + white-space: nowrap; +} + +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressDataFilterContainerHoverable { + border: var(--cx-border); + border-radius: 5px; + margin: 2px; + margin-bottom: 4px; +} + +div.CanvasXpressDataFilterHead, +div.CanvasXpressDataFilterHeadActive { + border: var(--cx-border); + border-radius: 4px; + box-sizing: border-box; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 38px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + text-align: left; + vertical-align: middle; +} + +div.CanvasXpressDataFilterHeadActive { + background:var(--cx-background-hover-color); + border-bottom: var(--cx-border-transparent) !important; + border-radius: 4px 4px 0px 0px; +} + +div.CanvasXpressDataFilterContainerTicks { + display: flex; + justify-content: space-between; + padding: 0px 10px; + height: 18px; +} + +span.CanvasXpressDataFilterContainerTicks, +span.CanvasXpressDataFilterContainerTicksLong { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + line-height: 10px; + margin-bottom: 10px; +} + +span.CanvasXpressDataFilterContainerTicks { + height: 5px; +} + +span.CanvasXpressDataFilterContainerTicksLong { + height: 10px; +} + +img.CanvasXpressDataFilterToolbarImage, +svg.CanvasXpressDataFilterToolbarImage { + border: var(--cx-border) !important; + border-radius: 5px !important; + padding: 2px; +} + +img.CanvasXpressDataFilterToolbarImageNB, +svg.CanvasXpressDataFilterToolbarImageNB { + border: none !important; +} + +span.CanvasXpressDataFilterText { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASElEQVR42mNkoBAwUt2A/0AAlgACsg0A6QWZQ4whOA2AsgkagtcAYgwhaAAhQ4gyAJ8htHcBRWFAUSxQlA7AEuSmRFLBwBsAAMDpRxF7e4BAAAAAAElFTkSuQmCC); +} + +span.CanvasXpressDataFilterTextActive { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASUlEQVR42mNkoBAwjhqAMOA/EBCtCQiwGoAkjhOA7MFqADGGoGvGGga4DMGmGWcgohuCSzNOA5ANwacZrwFIhuBVM4gS0oAZAAD1oisRsByngAAAAABJRU5ErkJggg==); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow, +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + box-sizing: border-box; + margin: 5px; + overflow: hidden; +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow { + border: var(--cx-border); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + border: none; +} + +input.CanvasXpressDateFilterContainerInputLeft { + float: left; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +input.CanvasXpressDateFilterContainerInputRight { + float: right; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +/***************/ +/* Toggle */ +/***************/ + +div.CanvasXpressToggle { + border: none; + margin: 5px; + height: 18px; +} + +label.CanvasXpressToggle { + cursor: pointer; +} + +div.CanvasXpressToggleSwitch { + display: inline-block; + background: rgb(204, 204, 204); + border-radius: 16px; + width: 28px; + height: 18px; + position: relative; + vertical-align: middle; + transition: background 0.25s; +} + +div.CanvasXpressToggleSwitch:before, +div.CanvasXpressToggleSwitch:after { + content: ""; +} + +div.CanvasXpressToggleSwitch:before { + display: block; + background: linear-gradient(to bottom, rgb(255, 255, 255) 0%, rgb(238, 238, 238) 100%); + border-radius: 50%; + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.25); + width: 14px; + height: 14px; + position: absolute; + top: 2px; + left: 2px; + transition: left 0.25s; +} + +label.CanvasXpressToggle:hover div.CanvasXpressToggleSwitch:before { + background: linear-gradient(to bottom, rgb(255, 255, 255)0%, rgb(255, 255, 255)100%); + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.5); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch { + background: var(--cx-background-color); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch:before { + left: 12px; +} + +input.CanvasXpressToggle { + position: absolute; + visibility: hidden; +} + +span.CanvasXpressToggle { + margin-left: 5px; + margin-right: 5px; + position: relative; +} + +/****************/ +/* Range Slider */ +/****************/ + +div.CanvasXpressRangeSliderContainer { + border: none; + margin: auto; + height: 110px; +} + +div.CanvasXpressRangeSliderContainerTop { + height: 18px; + margin: 5px; + position: relative; + display: flex; +} + +span.CanvasXpressRangeSliderContainerTop { + border: none; +} + +div.CanvasXpressRangeSliderContainerBottom { + height: 80px; + position: relative; +} + +div.CanvasXpressRangeSliderInput { + position: relative; + z-index: 10001; + height: 22px; + margin: 8px 0; +} + +input.CanvasXpressRangeSliderMin, +input.CanvasXpressRangeSliderMax { + color: var(--cx-background-color); + border: 1px solid var(--cx-background-widgets-color); + border-radius: 5px; + font: var(--cx-font); + margin-bottom: 2px; + line-height: 100%; + width: 60px; +} + +input.CanvasXpressRangeSliderMin { + float: left; + margin-left: 1px; +} + +input.CanvasXpressRangeSliderMax { + float: right; + margin-right: 1px; + text-align: right; +} + +div.CanvasXpressRangeSlider { + position: relative; + z-index: 10001; + height: 8px; + margin: 0 15px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderTrack { + position: absolute; + z-index: 10001; + left: 0; + right: 0; + top: 0; + bottom: 0; + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderRange { + background-color: var(--cx-background-color); + position: absolute; + z-index: 10002; + left: 0%; + right: 0%; + top: 0; + bottom: 0; + border-radius: 5px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + position: absolute; + z-index: 10003; + width: 18px; + height: 18px; + border-radius: 50%; + transition: box-shadow .3s ease-in-out; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + background-color: var(--cx-background-color); + box-shadow: 0 0 0 0 var(--cx-background-hover-color); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft { + left: 0%; + transform: translate(-15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + right: 0%; + transform: translate(15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft:hover, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight:hover { + box-shadow: 0 0 0 10px var(--cx-background-hover-color); +} + +input[type=range].customizerRightItemRangeSelect { + -webkit-appearance: none; + appearance: none; + width: 100%; + height: 8px; + border-radius: 5px; + background: var(--cx-color-extra-light-gray); + outline: none; + opacity: 1; +} + +input[type=range].customizerRightItemRangeSelect::-webkit-slider-thumb { + -webkit-appearance: none; + appearance: none; + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range].customizerRightItemRangeSelect::-moz-range-thumb { + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range] { + position: absolute; + pointer-events: none; + -webkit-appearance: none; + z-index: 10002; + height: 10px; + width: 100%; + opacity: 0; +} + +input[type=range]::-webkit-slider-thumb { + pointer-events: all; + width: 30px; + height: 30px; + border-radius: 0; + border: 0 none; + background-color: red; + -webkit-appearance: none; +} + +div.CanvasXpressRangeSliderTicks, +div.CanvasXpressRangeSliderTicksLog { + display: flex; + padding: 0px 10px; + height: 18px; + margin-top: 10px; +} + +div.CanvasXpressRangeSliderTicks { + justify-content: space-between; +} + +span.CanvasXpressRangeSliderTicksLong, +span.CanvasXpressRangeSliderTicks { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + margin-bottom: 10px; +} + +span.CanvasXpressRangeSliderTicksLong { + color: var(--cx-background-color); + height: 10px; + line-height: 35px; + font-size: small; +} + +span.CanvasXpressRangeSliderTicks { + height: 5px; + line-height: 10px; +} + +/** + * Input type number + */ + +input[type=number]::-webkit-inner-spin-button { + -webkit-appearance: none; +} + +/***************/ +/* Scrollbars */ +/***************/ + +/* All scrollbar buttons*/ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-button, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-button, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-button,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-button, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-button, +div.CanvasXpressDataExplorer::-webkit-scrollbar-button, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-button, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-button, +select.CanvasXpressConfigurator::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-button, +select.CanvasXpressSlider::-webkit-scrollbar-button, +div.cX-bin-name-container::-webkit-scrollbar-button { + width: 4px; + height: 4px; +} + +/* Tracks can be of two different colors */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track, +select.CanvasXpressConfigurator::-webkit-scrollbar-track, +select.CanvasXpressSlider::-webkit-scrollbar-track { + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track, +div.cX-bin-name-container::-webkit-scrollbar-track { + background-color: rgb(245, 245, 245); +} + +/* All tracks -hovers */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track:hover, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track:hover, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track:hover,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track:hover, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track:hover, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track:hover, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressConfigurator::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track:hover, +select.CanvasXpressSlider::-webkit-scrollbar-track:hover, +div.cX-bin-name-container::-webkit-scrollbar-track:hover { + background-color: var(--cx-background-hover-color); + border-radius: 8px; +} + +/* scrollbar background could be of two different colors but match the style tracks above */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar, +select.CanvasXpressConfigurator::-webkit-scrollbar, +select.CanvasXpressSlider::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar, +div.CanvasXpressDataTableVertical::-webkit-scrollbar, +div.CanvasXpressDataExplorer::-webkit-scrollbar, +div.CanvasXpressDataCustomizer::-webkit-scrollbar, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar, +div.cX-bin-name-container::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(245, 245, 245); +} + +/* All tracks thumbs */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-thumb, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-thumb, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-thumb,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-thumb, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-thumb, +div.CanvasXpressDataExplorer::-webkit-scrollbar-thumb, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressConfigurator::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-thumb, +select.CanvasXpressSlider::-webkit-scrollbar-thumb, +div.cX-bin-name-container::-webkit-scrollbar-thumb { + background-color: var(--cx-background-contrast-color); + border-radius: 8px; + border: none; +} + +div.CanvasXpressDataFilter::selection, +div.CanvasXpressDataFilterToolbar::selection { + background: var(--cx-color-transparent); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilterContainerItem::selection { + background: var(--cx-color-transparent); + color: var(--cx-background-color); +} + +/* + * Menu + */ + +div.CanvasXpressLink { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/gif;base64,R0lGODlh+gABAIcAAOLj4/Dw8P///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAP8ALAAAAAD6AAEAAAgfAAMIHEiwoMGBAAQcXMiwocOHECNKnEixosWLGCMGBAA7); + background-repeat: repeat-y; + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-font); + line-height: 100%; + margin: 0px; + opacity: 0.95; + padding: 0px; + position: absolute; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + position: relative; +} + +input.CanvasXpressTabMenuConfigurator { + display: none; +} + +input:not(:checked).CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + display: none; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + float: left; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + float: right; + width: 100%; + margin: 22 0 0 -100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + cursor: pointer; + -moz-user-select: none; + -ms-user-select: none; + -webkit-user-select: none; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + padding: 0.5px; + border: 1px solid rgb(238, 238, 238); + border-radius: 4px; + background: rgb(255, 255, 255) +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + margin: 0; + padding: 0.5px; + overflow: hidden; + font: var(--cx-font); + color: var(--cx-font-color); + line-height: 100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + display: block; + padding: 5px; + border: 1px solid rgb(238, 238, 238); + border-bottom: none; + border-top-left-radius: 4px; + border-top-right-radius: 4px; + background: rgb(255, 255, 255) +} + +input:first-child.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + padding-left: 0; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 1; +} + +input:checked.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 2; +} + +div.CanvasXpressMenu { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 100%; + margin: 0px; + padding: 0px; + position: absolute; + opacity: 0.95; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +ul.CanvasXpressList { + background: transparent; + border: 0px none; + cursor: default; + list-style: none; + margin: 0px; + overflow: auto; + padding: 2px !important; + height: calc(100% - 100px); +} + +li.CanvasXpressListItemSep { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + height: 100%; + line-height: 1px; + list-style: none; + margin: 0px; + padding: 1px; + /* width: 100%; */ + white-space: nowrap; +} + +input.CanvasXpressListItem { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 100%; + list-style: none; + margin: 0px; + padding: 1px; + white-space: nowrap; +} + +input[type=file] { + display: block; +} + +div.CanvasXpressListItem { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; +} + +li.CanvasXpressListItem { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemActive { + background: rgba(83, 105, 255, 0.1); + border-color: rgb(83, 105, 255); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemScrollTop { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAARUlEQVR42mNkQAMXL178z0Ah0NfXZ0Tmo3BAFkhLS+M1IDw8kmHlyuV41Tx9+hTFIjiDWAtggBSLGMmxgFSLGKkRB4QAAILWJXgE49MrAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollTopActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAbUlEQVR42mNkQAOHb/38z0AhsFVjZ0Tmo3BAFmjIsOHULMLJwKDs1sFwd1cFw5vvuC258eQXikWMyBYoSOC2QIYXYgEMgCx68hm3RQ9eICxihFkgzI/bAk0xVAuQLbr+CrdFbz9CLGKkRhwQAgBYqyubRxy5uAAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottom { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAASUlEQVR42mO8ePHifwYaA0YQAbJIWloar8Lw8EgMsZUrl+PV8/TpUwZ9fX1GRpgAqRYRawHcJ6RaRIoFGJbALCIcyvgBsgUgAACiryV42XltywAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottomActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAcklEQVR42mM8fOvnfwYaA0YQAbJImJ8NpyJNMQYGZbcODPG7uyoYrr/Cbfjbj78YbNXYGRlhAiCLFCRwWyTDi2oRyIInn3Fb8OAFxAK4T5At0pDBbZEIJ8QikAVvvuO24MYThAUYlsAsIjPo4QDZAhAAAK/AK5vjVTSgAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollSearch { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 1px; + width: 100%; +} + +input.CanvasXpressListItemScrollSearch { + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 3px; + outline-style: none; + outline-width: 0px; + padding-left: 5px; + width: 93%; +} + +a.CanvasXpressListItemA { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAActive { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrow { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrowActive { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +img.CanvasXpressListIcon, +svg.CanvasXpressListIcon { + background-position: center; + border: 0px none !important; + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + height: 24px; + line-height: 24px; + list-style: none; + left: 3px; + margin: 0px !important; + padding: 0px; + position: absolute; + top: 3px; + vertical-align: top; + width: 24px; + white-space: nowrap; + background: rgba(0, 0, 0, 0) !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; +} + +span.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin-right: 10px; + white-space: nowrap; +} + +input.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + white-space: nowrap; +} + +span.CanvasXpressListItemTextShort { + color: var(--cx-font-color); + cursor: pointer; + float: right; + font: var(--cx-small-font-italic); + line-height: 24px; + list-style: none; + margin-left: 10px; + white-space: nowrap; +} + +span.CanvasXpressListItemTextSep { + background-color: rgb(224, 224, 224); + border-bottom: 1px solid; + border-bottom-color: rgb(255, 255, 255); + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + line-height: 1px; + list-style: none; + margin: 2px 3px; + overflow: hidden; + white-space: nowrap; +} + +table.CanvasXpressListItemTable { + border: collapse; + line-height: 20px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + padding-left: 3px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +img.CanvasXpressToolbarHelp, +svg.CanvasXpressToolbarHelp { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + float: right; + margin: 0px 0px 0px 2px !important; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressToolbarHelp { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border-radius: 5px; + border: 1px solid rgb(83, 105, 255); + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +p.CanvasXpressToolbarHelp { + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + margin: 0px; + padding: 5px 5px 5px 20px; +} + +div.CanvasXpressForm { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + color: var(--cx-font-color); + cursor: move; + font: var(--cx-x-large-font); + margin: 8px; + padding: 8px; + position: absolute; + white-space: nowrap; +} + +input.CanvasXpressFormButton { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mP88OHDf0aSiGfPntGaAAAL8XAJa+SuYgAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 5px 5px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormButtonActive { + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mN89fnvf0aSiBvPf9GaAABVL3D5nF6uqAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 0px 0px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormText { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + padding-left: 3px; +} + +form.CanvasXpressFormForm { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + margin: 8px; + overflow: auto; + padding-left: 3px; +} + +div.CanvasXpressConfiguratorColor { + box-sizing: content-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-font); + color: rgb(34, 34, 34); + line-height: 18px; +} + +div.CanvasXpressConfiguratorColorMain { + box-sizing: content-box; + background-image: url(data:image/png;base64,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); + background-repeat: no-repeat; + box-sizing: content-box; + border: none; + font: var(--cx-font); + color:var(--cx-font-color); + float: left; + cursor: crosshair; +} + +div.CanvasXpressConfiguratorColorExtra { + box-sizing: content-box; + background-image: url(data:image/gif;base64,R0lGODlhDwAPAKEBAAAAAP///////////yH5BAEKAAIALAAAAAAPAA8AAAIklB8Qx53b4otSUWcvyiz4/4AeQJbmKY4p1HHapBlwPL/uVRsFADs=); + background-repeat: no-repeat; + border: none; + font: var(--cx-font); + color: var(--cx-font-color); + cursor: crosshair; + overflow: hidden; +} + +/* + * Slider + */ + +div.CanvasXpressSlider { + background: rgba(0, 0, 0, 0); + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 50%; + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSliderRemote { + background: rgba(0, 0, 0, 0); + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSlider:hover { + background: rgba(0, 0, 0, 0.4); +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSlider { + width: 20px; + height: 20px; + } +} + +div.CanvasXpressSliderLeft { + left: -50px; +} + +div.CanvasXpressSliderLeft img, +div.CanvasXpressSliderLeft svg { + margin: 5px 5px 3px 3px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderLeft { + left: -25px; + } + + div.CanvasXpressSliderLeft img, + div.CanvasXpressSliderLeft svg { + margin: -4px 0px 0px -2px; + } +} + +div.CanvasXpressSliderRight { + right: -50px; +} + +div.CanvasXpressSliderRight img, +div.CanvasXpressSliderRight svg { + margin: 5px 3px 3px 8px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderRight { + right: -25px; + } + + div.CanvasXpressSliderRight img, + div.CanvasXpressSliderRight svg { + margin: -4px -2px 0px 2px; + } +} + +div.CanvasXpressSliderDotsContainer { + top: 25%; +} + +div.CanvasXpressSliderDots { + width: 10px; + height: 10px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderDots { + width: 5px; + height: 5px; + margin-left: 1px; + margin-right: 1px; + } +} + +input.CanvasXpressSlider, +select.CanvasXpressSlider { + padding: 2px 3px 2px 2px; + cursor: default; + color: var(--cx-font-color); + border-left: none; + border-right: none; + border-top: none; + border-bottom: 1px solid rgb(83, 105, 255); + background: rgba(0, 0, 0, 0); + width: 100%; + max-Width: 100%; + line-height: 22px; + margin: 0; +} + +input.CanvasXpressSlider:focus, +select.CanvasXpressSlider:focus { + outline: 0; +} + + +/* +@media (max-width: 480px) { + img { + height : 16px; + width : 16px; + } +} +*/ + + +/* + * Parent Node + */ + +div.CanvasXpress-ParentNode { + /* + border: 1px solid 'rgba(0,0,0,0)' + margin: auto; + display: table; + padding: 0; + */ + -moz-transform: none; + -webkit-transform: none; + -o-transform: none; + -ms-transform: none; + transform: none; +} + +/* + * CanvasXpress Tab Panel + */ + +div.CanvasXpressTabPanel { + font: var(--cx-x-large-font); + float: left; + width: 100% +} + +/* Customizer */ + +div.CanvasXpressTabPanelCustomizer { + position: relative; + border-bottom: 1px solid rgb(238, 238, 238); + top: -10px; + overflow: hidden; +} + +div.CanvasXpressTabPanelRibbonSection { + width: fit-content; + position: relative; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + padding-left: 8px; + padding-top: 5px; + margin-top: 12px; + float: left; +} + +span.CanvasXpressTabPanelRibbonSection { + margin-left: -3px; + background-color: white; + position: absolute; + float: left; + top: -14px; + padding: 3px; +} + +div.CanvasXpressTabPanelRibbon { + float: left; + margin-right: 10px; +} + +span.CanvasXpressTabPanelRibbon { + color: var(--cx-font-color); + font: var(--cx-x-large-font); + line-height: 28px; + list-style: none; + white-space: nowrap; + position: relative; + height: 28px; +} + +div.CanvasXpressTabPanelRibbonContainer { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +svg.CanvasXpressTabPanelRibbon { + float: left; + border: 1px solid rgb(83, 105, 255); + margin-left: 5px; + margin-top: 5px; + padding: 2px; + border-radius: 5px; + background-color: rgb(255, 255, 255); +} + +svg.CanvasXpressTabPanelRibbon:hover { + background: rgba(83, 105, 255, 0.1) +} + +/* Header */ + +div.CanvasXpressTabPanelHeader { + font: var(--cx-x-large-font); + border-bottom: 2px solid rgb(83, 105, 255); + height: 38px; + width: 100%; + float: left; +} + +div.CanvasXpressTabPanelHeaderTab { + font: var(--cx-x-large-font); + margin-left: 20px; + margin-right: 20px; + float: left; +} + +input.CanvasXpressTabPanelHeader { + border-width: 1px 1px 0 1px; + border-color: rgb(83, 105, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +input.CanvasXpressTabPanelHeaderActive { + border-bottom-width: 2px; + border-left-color: rgb(83, 105, 255); + border-top-color: rgb(83, 105, 255); + border-right-color: rgb(83, 105, 255); + border-bottom-color: rgb(255, 255, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +/* Content */ + +div.CanvasXpressTabPanelContent { + display: block; + float: left; + width: 100%; + position: relative; +} + +/* Rows */ + +div.CanvasXpressRow { + clear: both; + display: flex; + flex-wrap: wrap; + float: left; + width: 100%; +} + +div.CanvasXpressRow:before, +div.CanvasXpressRow:after { + content: " "; + display: table; +} + +div.CanvasXpressRow:after { + clear: both; +} + +div.CanvasXpressRowColumnFull, +div.CanvasXpressRowColumnTwoThird, +div.CanvasXpressRowColumnThreeFourth, +div.CanvasXpressRowColumnFourFifth, +div.CanvasXpressRowColumnFiveSixth, +div.CanvasXpressRowColumnHalf, +div.CanvasXpressRowColumnThird, +div.CanvasXpressRowColumnFourth, +div.CanvasXpressRowColumnFifth, +div.CanvasXpressRowColumnSixth { + float: left; + /* + padding-left: 1rem; + padding-right: 1rem; + */ + -moz-box-sizing: border-box; + -webkit-box-sizing: border-box; + box-sizing: border-box; +} + +div.CanvasXpressRowColumnFull:hover, +div.CanvasXpressRowColumnTwoThird:hover, +div.CanvasXpressRowColumnThreeFourth:hover, +div.CanvasXpressRowColumnFourFifth:hover, +div.CanvasXpressRowColumnFiveSixth:hover, +div.CanvasXpressRowColumnHalf:hover, +div.CanvasXpressRowColumnThird:hover, +div.CanvasXpressRowColumnFourth:hover, +div.CanvasXpressRowColumnFifth:hover, +div.CanvasXpressRowColumnSixth:hover { + border: 1px dashed rgb(238, 238, 238); +} + +div.CanvasXpressRowColumnFull { + border: 1px dashed white; + width: 100%; +} + +div.CanvasXpressRowColumnFullActive { + border: 1px dashed rgb(83, 105, 255); + width: 100%; +} + +div.CanvasXpressRowColumnTwoThird { + border: 1px dashed white; + width: 66.7%; +} + +div.CanvasXpressRowColumnTwoThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 66.7%; +} + +div.CanvasXpressRowColumnThreeFourth { + border: 1px dashed white; + width: 75%; +} + +div.CanvasXpressRowColumnThreeFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 75%; +} + +div.CanvasXpressRowColumnFourFifth { + border: 1px dashed white; + width: 80%; +} + +div.CanvasXpressRowColumnFourFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 80%; +} + +div.CanvasXpressRowColumnFiveSixth { + border: 1px dashed white; + width: 83.4%; +} + +div.CanvasXpressRowColumnFiveSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 83.4%; +} + +div.CanvasXpressRowColumnHalf { + border: 1px dashed white; + width: 50%; +} + +div.CanvasXpressRowColumnHalfActive { + border: 1px dashed rgb(83, 105, 255); + width: 50%; +} + +div.CanvasXpressRowColumnThird { + border: 1px dashed white; + width: 33.3%; +} + +div.CanvasXpressRowColumnThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 33.3%; +} + +div.CanvasXpressRowColumnFourth { + border: 1px dashed white; + width: 25%; +} + +div.CanvasXpressRowColumnFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 25%; +} + +div.CanvasXpressRowColumnFifth { + border: 1px dashed white; + width: 20%; +} + +div.CanvasXpressRowColumnFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 20%; +} + +div.CanvasXpressRowColumnSixth { + border: 1px dashed white; + width: 16.6%; +} + +div.CanvasXpressRowColumnSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 16.6%; +} + +/* + * CanvasXpress + */ + +canvas.CanvasXpress { + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + user-select: none; + -ms-user-select: none; +} + +canvas.CanvasXpress:hover { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; +} + +canvas.CanvasXpressUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAQAAAAEACAYAAABccqhmAAAQn0lEQVR4nO3dX4gd133A8W/CLSztUrZ0Hzbgh01Z6BZUWIpKHKKHDcigB1EMVcAPwmxBUIea1g95UMFNEEENJhFFEa6dGOMoxijCMW4QJlHjoAZHyK1TFOqAFCSQiAwrWIMMa1jDCrYPZxcvK91zZu6dmTNz5/uBQbZXvvu7c+f3u2fOnD8gSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSZIkSVJffSZ3AOqFWWARmN8+/hSY2f7v03v+7ifA3e0/V4HfAx8A17f/VIUsAKraDLAMfBH4K2CJkOhV+Bj4LfAu8N/bf96u6LUljehR4CTwHrDV8HEDOAMcBAZ1v1FJwT7gOeAOzSf9sGMNeInQApFUsSngKHCF/MmeOq4BXyPckkgawwxwnNAplzuxyx7rwGlgrvKzIk24KeAEcI/8iTzusYGF4AE+BdAwx4BvUk/CfLR93B7y8zlCq6Ou330K+A7hUWOvWQC01xLwAqFnf1wfAr8C/g94n/As/zbhcV4RA2Bh+1gEvgDsJ4wlGNdN4KvA2xW8ltR5U4Rvxk3Ga2b/FHiakLB1mQNWgFcZ//bkLHYUqueWgKuMlkCbhKQ/yoOj+powIIwBeJVQgEZ5D3fw0aF66hijJc4qYfDPI82HPNQMofVxg9EK2YnmQ87LPoA8Zgn3sY8QLtoZ4I+3f/b77T9vE8a+36wphgHwMvBkyf/vLmEA0Iu0uxPtceAbhNZNGf8J/C3F+ymkpEcJz9EvEEarlb2vvkoY7voE1YyrnwMul4xjDXiG0FfQJUco3yK4Ruh4lEa2TBiWWjbhizRV3wGeYrTOqwXCBV7m950e8Xe1xRShAK9T7hZnf45g1V1ThHvQMgk2zrFBaMYX7XFfpNxovqtMVhLMA5co/v7XgQM5AlW3DAjN45xDZc8Tb7aWSf5Nwn3+pM6ue5riHZ8WAUUdZLRe5zqOncTde59eJvlXt9/TpFui+OdmEdADpgmDSHIn/cOOW3x6wc5RPPnfo12P9eo2DVyk2Lm5R72Dm9Qh+wlJljvRU62Bk4QhuEX+/hvkGciT2wB4nmLn6A5OJuq9o4w+4myD0An1bcIjvZ1x7bvvtXfWzztE6Fc4R/2LbjzP5N7vF/U1ireSuvYoVBU5zmhJf44wMGWcC2cf8CzVtzxOjxHTpHmGYufsbK4Alc9pyiXWKqFgVLUg5m6HKPc4y+QvrmgROJYrQDXvBOW+8U/QTDPxIMXv8fcerzUQX1edJH3+1rFTsBeOUTypLlHNXPUyBoT71zL9Er/Ae/6UIk94ruJ5nGjLFJsfv0lo7udU9Ln2Dbo9rLcpA4otfvpsrgBVr1mKPT9fpz0DZ2aAXxKPdV+26LqnyBiKDZw4NJHeIp38q5Sfblq3AeGZvh1X1ThI+jr4abboVIujdLsT6GFF4HzWiLqtyBOgQ9miU6VmSDf7Nmn/2PDdReAW3vePY4r0DM/3sUNwIjxHuto/lS26cgaEb/62F6suKHIrsJIrOFVjjvTjtDeyRafczpN+wmIroMNOEf+A16hnZJ+6YZ70F8TjuYLTeKZIrzFvL7pSHYJX8oWmcaRG/DnqS1DsNnGSllHrjXeIf6hH8oWmlkm1Ar6XLzSNYo74B3oLv/31qXniQ8TX6ciaAZ/NHUBLHE78/GXgfhOBqBNuAz+L/Hya9DWlFjlHvAXgWG/tdZj4NfN6vtBUVmzJrfczxqX2GhDf9KUTtwHeAoTn+rGVcN0/Xg9zH/hR5OfTdGAEZp86tuYITfmF7X/+I0Lip1Z5vVxzXOqunxA2GRnmMfwCyWKeMKPvDGFgRpk94fYebZ3xp/wGxK8tBwU1ZIowHfMFql81V4p5k+HXzib93GuhMcvAK4z3DZ96/i/FpFYRbn0/QNfMEBbBbGIH3qsNvSd116PEr6Fn8oWW1qVOwDngn4EnaW5xi48a+j3qrt8QnggMy6U/bzCWiTRDWKRj1O24xjlc601FxPZmeCdjXEltbgEMCDP0vkk9c/DvAx9Efj4L3K3h92ryXGf4asvzDcZRWlsLwBLwEtVMq7wN/Br4X8IHdZOQ+DbvVZWbkZ/1abv1sQ0I22oV2Yxj2HEPeJUwDsCtnNWEp4lfk/PZIuuQecLWy6Mk/QYh6Q/S3laNJtcR4tdn2/aOaJ3DpJfjethxg/CYxSWvldMy8et0OVdgXVBm593dib+C3/Zqh9RYgOVskbXYgLBFdZnEX8XEV/vME79uXU5uj2nCFtVFE3+TsA6bTX210Tzx63clV2BtNE2YYls0+a/hKqtqt3lsARRSNvlP04FVVdR7B7APIGkAXKRY4q9j1VR3LGMBSDpLseS/xfBhlVIbOQ4g4VmKJf9VHL2n7nEkYMQhiiX/ZVw9Rd30LeLXdm/NU2yEn8mvLnud4df2nYxxZTUgvd/eFmEutcmvLuvsegB1KnLffwfv+dVtU8Rnr76QL7R8FklP6V3H3lF1337i13mr1wSsyxXS3/5PZItOqo6rAu+xQjr53T9dk8J9AXaZJszYiyX/NXp2UjSxUjsD9W5Z+dTc/k3C3GlpEhwkfr2fyhda82ZIP/N/Plt0UvVOE7/eD+ULrXmpb/81nM/fNqdw0tWoBsRvd9fp0UzWKUKCxwpAbBtlNW/n22sTi8AoDhO/3l/PF1rzniJ+Mm7gMl5tsrfpahEoL9b737vH3KnlvFeyRaa9ht23WgSKmyc+0K1Xzf/USKhV/PZvi1SnlUWgmNR5/Dn1bGfXSqmTcTxfaNol9TlZBIqZo/hGtdeAM0z4hjV3iF9MTvbJr2jyWwTSyp7LnWONMAJ2oua/pBZDfDNfaNo26gVrEXhQmW//2HEJeLzh2GtxkvgbnYg32WGjJr9F4OHGPZ97jyt0fLJQrPd/gx71hLZQVRerRSCo6tv/YcdrdLDTcIb4m7qQL7Teq/qbyiJQ/Tnde6yRocU8Ts9kquny1hivrdGdBv6x4tccAOe2//nHFb92V1whzO6bBf5w+7/9CeGLcBZ4BFhg9Jmus4Q+s+8D/wDcHyfYJqTu/xfzhdZbdX9L2RJI20cY+HaO+FTh2HGZDjw9u8DwN3AvY1x9VXfyWwTKmyI06y+QXiJv73GN0KJorVsMD977/2YVTf5V4lO2b1DsQrUIlLdA2B2rTCFYpaUt6SnigX87X2i9Uyb5F4kX7lcIiW0RqM8iYahwmSLQutuBfcSDPpYvtF4pm/yQLgBgEWjCCsX7CFq3jF5qu6/lbJH1xyjJD8UKAFgEmjBPeLJQ5HO8SIvmE6wQD3Y+V2A9MWryQ/ECABaBJkwDb1Ds8zyRKcYHHCceaGsq1QQaJ/mhXAEAi0ATBsDLFDvHrVhU9+vEA1U9xk1+KF8AwCLQlPOkz/E1WjDEPlYAbmWMa5JVkfwwWgEAi0ATBoR7/dQ5PpkrwB2vYAFoUlXJD6MXALAINGGGMB4jdn43CEOPs7EANKfK5IfxCgBYBJqwRPocn80WHfCtIUFZAKpVdfLD+AUALAJNKLLLVrahwrE+gI1cQU2YOpIfqikAYBGo2xTpW4HTuYLzKUC96kp+qK4AgEWgbo8TP6/3yPREYCURWNYOio6rM/mh2gIAFoG6pUYKruQIKlWZ9ucIagLUnfxQfQEAi0CdjhA/pz/PEVRqMxA/5PKaSH6opwCARaAuqU1IN8kwUWg2EtAWbgZSVlPJD/UVALAI1OU5WviFG1tYolc7o46pyeSHegsAWATqkGpxn8kR1JVIQDdyBNRBTSc/1F8AwCJQh9htwNUcAZ2JBLRFGNKo4XIkPzRTAMAiULXXiZ/DxmfgrkQC2sJdgWJyJT80VwDAIlClZ4ifw31NB7SYCOiFpgPqiJzJD80WALAIVCW1CtfhHEHF7kvu5Aio5XInPzRfAMAiUIV54ufuqRxBvZIIaqK2Qh5TG5If8hQAsAiMa0D8vH09R1BHE0GdyhFUC6VGTjaV/JCvAEDxIrBBC5fCboHY5qRZCsB0IqhVXB9wR6oF0NQmEDkLAKSLgC2A4WKf3Uu5gnozEtQWfpi7DSsCTe4Ak7sAwPAiYPLHtbIAPBEJagu4lCuwltpbBJre/qkNBQAeLAImf1rrbgEgzEeODQvews7AvXaKQI6939pSAODTImDyFxPLsWwFANL3t2/mC621TpBn48c2FQAIiW/yp80Tz7EsjwF3LAwJylZA+7StAKiYWgYCfbai4G4C/5H4O/9W0e+S+ig11Pf2KC9aVQGA9L5ly4QOQ0nlfSHys0+A600FEpN6JHgHZwnm5i1AN60x/HN7b9QXrbIFAOlWwCNkXMpY6qgDhFW4hvnVqC9cdQH4DfDDxN95kkwzl6SO+kri579sJIqC5kiPC1jDpcNz8RagW1KLgm4wxqKgVbcAAO4C/5L4O7OE/oLs2xxLLXeE+MSonwEfNxRLKZdIjw14LVt0/WULoFtSG4O09snaPLBOughk3+u8ZywA3ZGaZ7NGy1vRK6QLwBZhvTM1wwLQDVPEP6stOrLexlksAm1iAeiGU8TzpTOLpkwRBioUKQLuKFQ/C0D7HSC9clKnxtPMEX+Usfv4Hq4iVCcLQLvNEUbMxnLkHh359t9tkWKdglvAL4iPfNLoLADtNQAuM8Et5QMULwK3gEfzhDnRLADtNADeIJ0XV+l4C7lMEdgkzC/o9BtuGQtA+xRN/k0mZF2NMkVgp+rtzxLp5LEAtMs0cJFieTBRT8r2U7xjcKf6vUwHOz9axgLQHvuAaxS7/s9nirFWCxQ/ATvHOuG2wHUFRmMBaIenKd4KvsIYE37abhp4i3JFYIvwKOQ0YcixirMA5LUEvEPx6/waPWn1HqfYtlEPuzW4QJg11epx0S1hAchjgTAqtsw13pvk37Gf8rcEe28PXiVMovAW4eEsAM2ZIuwLeYHy1/L79Cz5d0wRxkGP0hrYe1wFzhAmJS1hCwEsAHVbJFxv5yj3pGv3cZGG7vk/08QvGdESIXkPVPy6H2wfd4GPCIsprFX8O3L6IfElom8xvN/kB8DfRf7fJeBvRglqQv0BYWWracI5XWT8xP1X4BvA/TFfZ2I8Adxg/NZAX47lxPkcpwWw0oL3N6nHHcLmH42qY0mwqv0I+AvCN9PNzLFIdfg+8JeE5b0a1YUCAKE59ANCIfgK8G7WaKRq/Bfw18DfE25HG9eVArDjPvBj4IuEivld4MOsEUnlvQ18efv4dc5AulYAdvst8E/A54DHgBcJnXtSG30I/Dvhi+sxwrd/dpMwy+4+oaK+DXyV0BO7DHyJMJ14IVtk6rvrhOvyJ4SEb13P/iQUgL2ubx8vbv/7NGHSxQLwZ8DnE///NPUuRjJLvc94P6nxtT9mxF1oJ9wnhMfKN4HfEa6/d/H2VC00zmNATZgu9wFIGpMFQOoxC4DUYxYAqccsAFKPWQCkHrMASD1mAZB6zAIg9ZgFQOoxC4DUYxYAqccsAFKPWQCkHrMASD1mAZB6zAIg9ZgFQOoxC4DUYxYAqccsAFKPWQCkHrMASD1mAZB6zAIg9ZgFQOoxC4DUYxYAqccsAFKPWQCkHrMASD02yB2AGvc/wO0hP/tdg3FIkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRJkiRl9P8s0/RVv6+5CQAAAABJRU5ErkJggg=='); + background-size: contain; + background-repeat: no-repeat; +} + +canvas.CanvasXpress::selection { + background: rgba(0, 0, 0, 0); + color: rgb(0, 0, 0); +} + +div.CanvasXpressPlay { + background-color: rgba(0, 0, 0, 0.05); + background-image: url('data:image/png;base64,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'); + background-position-x: 50%; + background-position-y: center; + background-size: 25%; + background-repeat: no-repeat; + position: absolute; +} + +div.CanvasXpressPlay:hover { + background-color: rgba(0, 0, 0, 0); +} + +div.CanvasXpressContainer { + box-sizing: border-box; + position: relative; + float: left; +} + +div.CanvasXpressWrapper { + box-sizing: border-box; + position: relative; + float: left; + line-height: 100%; +} + +/* + * full-screen-warning-container + */ + +#full-screen-warning-container { + background-color: transparent !important; + opacity: 0.4 !important; +} + +#full-screen-warning-container[fade-warning-out] { + transition-property: opacity !important; + transition-duration: 1ms !important; + opacity: 0.0 !important; +} + +#full-screen-warning-message { + padding: 15px !important; +} + +.full-screen-description { + font-size: 100% !important; +} + +#full-screen-domain-text { + font-size: 100% !important; + font-weight: bold !important; +} + +.full-screen-approval-button, +#full-screen-remember-decision { + font-size: 100% !important; +} + +@media (min-width: 300px) { + div.cX-bin { + transform: scale(0.5); + } +} + +@media (min-width: 450px) { + div.cX-bin { + transform: scale(0.75); + } +} + +@media (min-width: 600px) { + div.cX-bin { + transform: scale(1); + } +} + + +/* Genie Effect */ + +.genie { + position: relative; + background-repeat: no-repeat; + background-size: cover; +} + +.genie .genie-step { + background-repeat: no-repeat; + background-image: inherit; + position: absolute; +} + +.genie.genie-expand .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-collapse .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +.genie.genie-collapse.change-pace .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-expand.change-pace .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +/* Hide Efect */ + +.appear { + transition: all 1s linear; + opacity: 1; +} + +.dissapear { + display: none; +} + +.dissapearHidden { + transition: all 1s linear; + opacity: 0; +} + +/* Magic Effects */ + + +/* +Magic - Ver 1.3.0 - https://minimamente.com +Licensed under the MIT license +Copyright (c) 2018 Christian Pucci +*/ + +.magictime { + -webkit-animation-duration: 1s; + animation-duration: 1s; + -webkit-animation-fill-mode: both; + animation-fill-mode: both; +} + +.showIn { + -webkit-animation-name: showIn; + animation-name: showIn; +} + +@-webkit-keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +@keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +.showOut { + -webkit-animation-name: showOut; + animation-name: showOut; +} + +@-webkit-keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +@keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +.puffIn { + -webkit-animation-name: puffIn; + animation-name: puffIn; +} + +@-webkit-keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.puffOut { + -webkit-animation-name: puffOut; + animation-name: puffOut; +} + +@-webkit-keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +@keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +.vanishIn { + -webkit-animation-name: vanishIn; + animation-name: vanishIn; +} + +@-webkit-keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.vanishOut { + -webkit-animation-name: vanishOut; + animation-name: vanishOut; +} + +@-webkit-keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.boingInUp { + -webkit-animation-name: boingInUp; + animation-name: boingInUp; +} + +@-webkit-keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.boingOutDown { + -webkit-animation-name: boingOutDown; + animation-name: boingOutDown; +} + +@-webkit-keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +@keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +.foolishIn { + -webkit-animation-name: foolishIn; + animation-name: foolishIn; +} + +@-webkit-keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +@keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +.foolishOut { + -webkit-animation-name: foolishOut; + animation-name: foolishOut; +} + +@-webkit-keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +@keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +.holeIn { + -webkit-animation-name: holeIn; + animation-name: holeIn; +} + +@-webkit-keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +@keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +.holeOut { + -webkit-animation-name: holeOut; + animation-name: holeOut; +} + +@-webkit-keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +@keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +.swashIn { + -webkit-animation-name: swashIn; + animation-name: swashIn; +} + +@-webkit-keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +@keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +.swashOut { + -webkit-animation-name: swashOut; + animation-name: swashOut; +} + +@-webkit-keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +@keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +.bombLeftOut { + -webkit-animation-name: bombLeftOut; + animation-name: bombLeftOut; +} + +@-webkit-keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.bombRightOut { + -webkit-animation-name: bombRightOut; + animation-name: bombRightOut; +} + +@-webkit-keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.magic { + -webkit-animation-name: magic; + animation-name: magic; +} + +@-webkit-keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +@keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +.swap { + -webkit-animation-name: swap; + animation-name: swap; +} + +@-webkit-keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +@keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +.twisterInDown { + -webkit-animation-name: twisterInDown; + animation-name: twisterInDown; +} + +@-webkit-keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +@keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +.twisterInUp { + -webkit-animation-name: twisterInUp; + animation-name: twisterInUp; +} + +@-webkit-keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +@keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +.spaceInDown { + -webkit-animation-name: spaceInDown; + animation-name: spaceInDown; +} + +@-webkit-keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInLeft { + -webkit-animation-name: spaceInLeft; + animation-name: spaceInLeft; +} + +@-webkit-keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInRight { + -webkit-animation-name: spaceInRight; + animation-name: spaceInRight; +} + +@-webkit-keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInUp { + -webkit-animation-name: spaceInUp; + animation-name: spaceInUp; +} + +@-webkit-keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceOutDown { + -webkit-animation-name: spaceOutDown; + animation-name: spaceOutDown; +} + +@-webkit-keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +@keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +.spaceOutLeft { + -webkit-animation-name: spaceOutLeft; + animation-name: spaceOutLeft; +} + +@-webkit-keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +@keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +.spaceOutRight { + -webkit-animation-name: spaceOutRight; + animation-name: spaceOutRight; +} + +@-webkit-keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +@keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +.spaceOutUp { + -webkit-animation-name: spaceOutUp; + animation-name: spaceOutUp; +} + +@-webkit-keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +@keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +.perspectiveDown { + -webkit-animation-name: perspectiveDown; + animation-name: perspectiveDown; +} + +@-webkit-keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +@keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +.perspectiveDownReturn { + -webkit-animation-name: perspectiveDownReturn; + animation-name: perspectiveDownReturn; +} + +@-webkit-keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.perspectiveLeft { + -webkit-animation-name: perspectiveLeft; + animation-name: perspectiveLeft; +} + +@-webkit-keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +@keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +.perspectiveLeftReturn { + -webkit-animation-name: perspectiveLeftReturn; + animation-name: perspectiveLeftReturn; +} + +@-webkit-keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveRight { + -webkit-animation-name: perspectiveRight; + animation-name: perspectiveRight; +} + +@-webkit-keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +@keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +.perspectiveRightReturn { + -webkit-animation-name: perspectiveRightReturn; + animation-name: perspectiveRightReturn; +} + +@-webkit-keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveUp { + -webkit-animation-name: perspectiveUp; + animation-name: perspectiveUp; +} + +@-webkit-keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +@keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +.perspectiveUpReturn { + -webkit-animation-name: perspectiveUpReturn; + animation-name: perspectiveUpReturn; +} + +@-webkit-keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.rotateDown { + -webkit-animation-name: rotateDown; + animation-name: rotateDown; +} + +@-webkit-keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +@keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +.rotateLeft { + -webkit-animation-name: rotateLeft; + animation-name: rotateLeft; +} + +@-webkit-keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +@keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +.rotateRight { + -webkit-animation-name: rotateRight; + animation-name: rotateRight; +} + +@-webkit-keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +@keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +.rotateUp { + -webkit-animation-name: rotateUp; + animation-name: rotateUp; +} + +@-webkit-keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +@keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +.slideDown { + -webkit-animation-name: slideDown; + animation-name: slideDown; +} + +@-webkit-keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown2 { + -webkit-animation-name: slideDown2; + animation-name: slideDown2; +} + +@-webkit-keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown3 { + -webkit-animation-name: slideDown3; + animation-name: slideDown3; +} + +@-webkit-keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDownReturn { + -webkit-animation-name: slideDownReturn; + animation-name: slideDownReturn; +} + +@-webkit-keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideDownReturn2 { + -webkit-animation-name: slideDownReturn2; + animation-name: slideDownReturn2; +} + +@-webkit-keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideLeft { + -webkit-animation-name: slideLeft; + animation-name: slideLeft; +} + +@-webkit-keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +@keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +.slideLeftReturn { + -webkit-animation-name: slideLeftReturn; + animation-name: slideLeftReturn; +} + +@-webkit-keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideLeftReturn2 { + -webkit-animation-name: slideLeftReturn2; + animation-name: slideLeftReturn2; +} + +@-webkit-keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideRight { + -webkit-animation-name: slideRight; + animation-name: slideRight; +} + +@-webkit-keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +@keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +.slideRightReturn { + -webkit-animation-name: slideRightReturn; + animation-name: slideRightReturn; +} + +@-webkit-keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideUp { + -webkit-animation-name: slideUp; + animation-name: slideUp; +} + +@-webkit-keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUp2 { + -webkit-animation-name: slideUp2; + animation-name: slideUp2; +} + +@-webkit-keyframes slideUp2 { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp2 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUpReturn { + -webkit-animation-name: slideUpReturn; + animation-name: slideUpReturn; +} + +@-webkit-keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideUpReturn2 { + -webkit-animation-name: slideUpReturn2; + animation-name: slideUpReturn2; +} + +@-webkit-keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.openDownLeft { + -webkit-animation-name: openDownLeft; + animation-name: openDownLeft; +} + +@-webkit-keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownLeftReturn { + -webkit-animation-name: openDownLeftReturn; + animation-name: openDownLeftReturn; +} + +@-webkit-keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownRight { + -webkit-animation-name: openDownRight; + animation-name: openDownRight; +} + +@-webkit-keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightReturn { + -webkit-animation-name: openDownRightReturn; + animation-name: openDownRightReturn; +} + +@-webkit-keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpLeft { + -webkit-animation-name: openUpLeft; + animation-name: openUpLeft; +} + +@-webkit-keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftReturn { + -webkit-animation-name: openUpLeftReturn; + animation-name: openUpLeftReturn; +} + +@-webkit-keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpRight { + -webkit-animation-name: openUpRight; + animation-name: openUpRight; +} + +@-webkit-keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightReturn { + -webkit-animation-name: openUpRightReturn; + animation-name: openUpRightReturn; +} + +@-webkit-keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownLeftOut { + -webkit-animation-name: openDownLeftOut; + animation-name: openDownLeftOut; +} + +@-webkit-keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightOut { + -webkit-animation-name: openDownRightOut; + animation-name: openDownRightOut; +} + +@-webkit-keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftOut { + -webkit-animation-name: openUpLeftOut; + animation-name: openUpLeftOut; +} + +@-webkit-keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightOut { + -webkit-animation-name: openUpRightOut; + animation-name: openUpRightOut; +} + +@-webkit-keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.tinDownIn { + -webkit-animation-name: tinDownIn; + animation-name: tinDownIn; +} + +@-webkit-keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinDownOut { + -webkit-animation-name: tinDownOut; + animation-name: tinDownOut; +} + +@-webkit-keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +@keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +.tinLeftIn { + -webkit-animation-name: tinLeftIn; + animation-name: tinLeftIn; +} + +@-webkit-keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinLeftOut { + -webkit-animation-name: tinLeftOut; + animation-name: tinLeftOut; +} + +@-webkit-keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +@keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +.tinRightIn { + -webkit-animation-name: tinRightIn; + animation-name: tinRightIn; +} + +@-webkit-keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinRightOut { + -webkit-animation-name: tinRightOut; + animation-name: tinRightOut; +} + +@-webkit-keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +@keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +.tinUpIn { + -webkit-animation-name: tinUpIn; + animation-name: tinUpIn; +} + +@-webkit-keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinUpOut { + -webkit-animation-name: tinUpOut; + animation-name: tinUpOut; +} + +@-webkit-keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +@keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +.blink { + -webkit-animation-name: blink; + animation-name: blink; +} + +@-webkit-keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} + +@keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} \ No newline at end of file diff --git a/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.min.js b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.min.js new file mode 100644 index 0000000..bef6f56 --- /dev/null +++ b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.min.js @@ -0,0 +1,303 @@ +/** + * + * CanvasXpress 58.7 - JavaScript Canvas Library + * + * Copyright (c) 2009-2025 - license@canvasxpress.org + * + * Redistributions of the source code must retain this copyright + * notice and the following disclaimer. + * + * CanvasXpress is released as open source for personal and + * educational use with dual licensing for commercial purposes. + * + * This program is distributed in the hope that it will be useful, + * but WITHOUT ANY WARRANTY; without even the implied warranty of + * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. + * + * Please see a copy of the CanvasXpress License at + * https://www.canvasxpress.org/docs/license.html. + * + * Dual licensing: + * Commercial use may be granted to the extent that this source + * code does NOT become part of any other Open Source or + * Commercially licensed development library or toolkit without + * explicit permission from CanvasXpress. + * + */ +/** + * + * sprintf() for JavaScript v.0.4 + * + * Copyright (c) 2007 Alexandru Marasteanu + * Thanks to David Baird (unit test and patch). + * + * This program is free software; you can redistribute it and/or modify it under + * the terms of the GNU General Public License as published by the Free Software + * Foundation; either version 2 of the License, or (at your option) any later + * version. + * + * This program is distributed in the hope that it will be useful, but WITHOUT + * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS + * FOR A PARTICULAR PURPOSE. See the GNU General Public License for more + * details. + * + * You should have received a copy of the GNU General Public License along with + * this program; if not, write to the Free Software Foundation, Inc., 59 Temple + * Place, Suite 330, Boston, MA 02111-1307 USA + * + *** + * + * Date Format 1.2.3 + * (c) 2007-2009 Steven Levithan + * MIT license + * + * Includes enhancements by Scott Trenda + * and Kris Kowal + * + * Accepts a date, a mask, or a date and a mask. + * Returns a formatted version of the given date. + * The date defaults to the current date/time. + * The mask defaults to dateFormat.masks.default. + * + **** + * + * jLouvain.js + * Author: Corneliu S. (github.com/upphiminn) + * This is a javascript implementation of the Louvain + * community detection algorithm (http://arxiv.org/abs/0803.0476) + * Based on https://bitbucket.org/taynaud/python-louvain/overview + * + **** + * + * science.js + * Copyright (c) 2011, Jason Davies + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * The name Jason Davies may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND + * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED + * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE + * DISCLAIMED. IN NO EVENT SHALL JASON DAVIES BE LIABLE FOR ANY DIRECT, INDIRECT, + * INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT + * LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR + * PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF + * LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE + * OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF + * ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * Apache-Style Software License for ColorBrewer software and ColorBrewer Color + * Schemes + * + * Copyright (c) 2002 Cynthia Brewer, Mark Harrower, and The Pennsylvania State + * University. + * + * Licensed under the Apache License, Version 2.0 (the "License"); you may not + * use this file except in compliance with the License. You may obtain a copy of + * the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, WITHOUT + * WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the + * License for the specific language governing permissions and limitations under + * the License. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * 1. Redistributions as source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * 2. The end-user documentation included with the redistribution, if any, must + * include the following acknowledgment: "This product includes color + * specifications and designs developed by Cynthia Brewer + * (http://colorbrewer.org/)." Alternately, this acknowledgment may appear in the + * software itself, if and wherever such third-party acknowledgments normally + * appear. + * + * 4. The name "ColorBrewer" must not be used to endorse or promote products + * derived from this software without prior written permission. For written + * permission, please contact Cynthia Brewer at cbrewer@psu.edu. + * + * 5. Products derived from this software may not be called "ColorBrewer", nor + * may "ColorBrewer" appear in their name, without prior written permission of + * Cynthia Brewer. + * + **** + * + * FileSaver.js + * Copyright © 2015 [Eli Grey][1]. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * canvas-toBlob.js + * Copyright © 2011 Eli Grey and Devin Samarin. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * Blob.js + * Copyright © 2014 Eli Grey. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * jstat.js + * Copyright (c) 2013 jStat + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * numeric.js + * Numeric Javascript + * Copyright (C) 2011 by Sébastien Loisel + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * Sankey.js + * Copyright (c) 2012, Michael Bostock + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * * The name Michael Bostock may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" + * AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE + * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE + * ARE DISCLAIMED. IN NO EVENT SHALL MICHAEL BOSTOCK BE LIABLE FOR ANY DIRECT, + * INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES + * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; + * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND + * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT + * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS + * SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * canvas2svg + * The MIT License (MIT) + * + * Copyright (c) 2014 Gliffy Inc. + * + * Permission is hereby granted, free of charge, to any person obtaining a copy of + * this software and associated documentation files (the "Software"), to deal in + * the Software without restriction, including without limitation the rights to + * use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of + * the Software, and to permit persons to whom the Software is furnished to do so, + * subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS + * FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR + * COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER + * IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + * CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + */ +(function(b,a){if(typeof exports==="object"){a(exports)}else{(a((b.CanvasXpress=b.CanvasXpress||{})))}}(this,(function(){CanvasXpress=typeof CanvasXpress!="undefined"&&CanvasXpress.ready?CanvasXpress:function(n,h,e,s,d,p,r,l){var k=this;var q=function(){k.init(n,h,e,s,d,p,r,l)};var c=function(i){if(i){k.init(i);if(r){r(i)}}else{k.init(n,h,e,s,d,p,r,l)}};var j=document.styleSheets;var b=false;for(var g=0;g-1){b=true;break}}if(e&&typeof e=="string"){e={prompt:e,llmBehaviour:"update",view:"table"}}else{if(n&&n.config&&n.config.prompt&&n.config.isR){n.config.llmBehaviour="update";n.config.view="table"}}if(!b){var 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provided")}else{if(typeof(f)=="object"&&f.renderTo){d=f.tracks?{tracks:f.tracks}:f.nodes?{nodes:f.nodes}:f.venn?{venn:f.venn}:f.data?f.data:false;b=f.config||false;if(f.version){b.createVersion=f.version}if(f.factory){b.createFactory=f.factory}c=f.events||false;e=f.info?f.info.replace(/'/g,"'").replace(/"/g,"'"):false;h=f.afterRender||false;g=f.callback||false;a=f.noValidate?f.noValidate:b&&b.noValidate?b.noValidate:false;f=f.renderTo;CanvasXpress.inject(f)}else{if(typeof f==="string"||f instanceof String){CanvasXpress.inject(f)}}}return{target:f,data:d,config:b,events:c,info:e,afterRender:h,callback:g,noValidate:a}};CanvasXpress.inject=function(c){if(typeof c==="string"||c instanceof String){var b=document.getElementById(c);if(b!==null){if(b.tagName.toLowerCase()=="canvas"){if(!b.width){b.width=500}if(!b.height){b.height=500}}else{if(b.tagName.toLowerCase()=="div"){b.id=c+"-div";var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;b.appendChild(a)}}}else{var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;document.body.appendChild(a)}}};CanvasXpress.loadFonts=function(d,c){if(d&&d.length&&c){var b=false;for(var a=0;a: "+k.parameters[l]+"

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z=document.createElement("div");z.style.width=w+"px";z.style.height="100px";z.style.clear="both";z.style.position="relative";z.style.margin="auto";var n=document.createElement("span");n.innerHTML=a.datetime;n.style.cssFloat="right";var d=document.createElement("span");d.innerHTML=a.prompt;d.style.cssFloat="left";d.style.fontWeight="bold";var y=document.createElement("span");y.innerHTML=a.client;y.style.cssFloat="left";var x=document.createElement("br");var v=document.createElement("br");var h=document.createElement("br");z.appendChild(x);z.appendChild(y);z.appendChild(n);z.appendChild(v);z.appendChild(d);z.appendChild(h);return z};var e=function(h,d){var n=document.createElement("div");if(d){n.className=d}n.appendChild(h);return n};var j=function(w,h){var x=CanvasXpress.parametersLLM;h.CZ();var n=h.meta.config.user;var d={graphOrientation:true,graphType:true,isR:true,prompt:true};for(var v=0;v=0){that.rY([vi,x,y]);draw=true}if(si>=0){that.rY([that.varIndices[0],si]);draw=true}}if(draw){that.z4()}}};var isPWC=function(){for(var i=0;i0?ar.shift():[];var cn=ar.length>0?ar.shift():{};var tm=ar.length>0?ar.shift():t;var rp=ar.length>0?ar.shift():false;if(this.view=="table"&&fn=="setDimensions"){continue}if(fn=="setDimensions"){if(this.width==pr[0]&&this.height==pr[1]){continue}}if(fn=="clickView"){cv=true;continue}if(fn=="updateDataFilter"||fn=="resetDataFilter"){this.skipRender=true}var dr=arr[i+1]&&arr[i+1][0]&&arr[i+1][0].match(/drag/i)?true:false;this.skipRender=fn=="createDOE"||fn=="createHistogram"||fn=="modifyColorScheme"||fn.match(/segregate/)||dr?false:!this.showTransition&&i0&&!CanvasXpress.readyFonts){CanvasXpress.readyFonts=true;return}t.fo("canvasXpress data ready - 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t=this;t.wu(o);t.GW("init");t.T4();t.gh(o);t.uU();t.Ki();t.Vd();t.YX();t.uo(o.config);t.y8();t.Pw();t.CI();t.jY(o.data);t.GW("initData");t.sb();t.EP();t.fR();t.zA();t.sw(o.data,o.config,o.events,o.info,o.afterRender);t.wE();t.Ki();t.c9(o.callback)};this.uY(o)};CanvasXpress.prototype.initStart=function(){this.initIO();this.initCrypt();this.initDOM();this.initViewport();this.initConfig()};CanvasXpress.prototype.initDataset=function(){this.yi=function(){delete (this.meta.data);this.cN(false,false,false,true)};this.af=function(c){if(c){this.meta.data={tracks:[]}}for(var H=0;HF){F=g;K=x[B].length;u=x[B]}}var e=[];for(var B=0;BI){I=h;O=B[H].length;A=B[H]}}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A;c.colors=[];var p=0;for(var H=0;HI){I=h;O=c.levels[H].toString().length;A=c.levels[H]}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A}c.shapes=this.shapes;c.sizes=this.sizes;c.patterns=this.patterns}P[E][G]=c}}}}if(this.decorations.length&&this.decorationsType=="heatmap"){var u=[];P.decorations={};P.decorations.unique=false;P.decorations.type="Numeric";P.decorations.n=0;for(var H=0;HI){I=h;O=P.decorations.levels[H].toString().length;A=P.decorations.levels[H]}P.decorations.maxLevLen=I;P.decorations.maxLevChr=O;P.decorations.maxLevStr=A}}}};this.FV=function(O,af,ac,P,ah){var J=this;var G=this.meta.config.user;var A=this.meta.data;var l=this.data;var C=CanvasXpress.colorSchemes;var p=["x","z","w"];var Y=this.font;var D=function(s,a,r,ai,al,ak){var t={};if(J.legendOrder&&J.legendOrder[s]){for(var aj=0;ajr[r.length-1]){t--;while(!C[J[ai+"Key"][U]][t]){t--}}else{if(td.length&&d.length==1&&J.graphType=="Map"){var t=S.length;var r=J.p4(C[J.colorScheme]);r.sort(function(aj,j){return aj-j});if(t>r[r.length-1]){t--;while(!C[J.colorScheme][t]){t--}}else{if(t10?d.colorBrew.vals:aj;d.order={};for(var s=0;sag){ag=t;c=d.levels[s].toString().length;aa=d.levels[s]}d.maxLevLen=ag;d.maxLevChr=c;d.maxLevStr=aa}}else{d[a+"s"]=a=="connect"?J.colors:J[a+"s"]}};if(!O||O=="w"||O=="x"||O=="z"){if(O&&ac){if(!af){delete (A[O])}else{if(A[O][af]){delete (A[O][af])}}}for(var X=0;Xag){ag=E;c=S[V].length;aa=S[V]}}I.maxLevLen=ag;I.maxLevChr=c;I.maxLevStr=aa;Z("color",this.colors,I);Z("shape",this.shapes,I);Z("size",this.Pk(S.length),I);Z("pattern",this.patterns,I);Z("linePattern",this.linePatterns,I);Z("connect",this.colors,I)}else{I.unique=false;I["boolean"]=false;for(var V=0;VA.m[T].maxFacLen){A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}else{A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}}if(P){return}var w,H,R;if(T=="z"){w="y";H="vars";R="Var"}if(T=="x"||T=="q"){w="y";H="smps";R="Smp"}if(T=="w"){w="w";H="smps";R="Smp"}var ag=0;var c=0;var aa="";if(l[w]){for(var V=0;Vthis.fullTextMeasureCheck){var L=l[w][H][V].toString().length;if(L>c){var E=this.HR(l[w][H][V],Y);if(E>ag){ag=E;c=L;aa=l[w][H][V]}}}else{if(l[w][H][V]!=null){var L=l[w][H][V].toString().length;if(L>=c){var E=this.HR(l[w][H][V].toString(),Y);if(E>ag){ag=E;c=L;aa=l[w][H][V].toString()}}}}}A[w]["max"+R+"Len"]=ag;A[w]["max"+R+"Chr"]=c;A[w]["max"+R+"Str"]=aa;A[w].vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";A[w].smps=this.nn(l.y.smps)?"World":this.RX(l.y.smps)?"USA":this.Ng(l.y.smps,true)?"Date":"String";if(A[w].smps=="Date"){A[w].date=this.vy(l.y.smps)}if(T=="x"){var ab={};var z=l.y.smps;for(var V=0;Vthis.fullTextMeasureCheck){var L=l.y.vars[V].toString().length;if(L>c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}else{if(l.y.vars[V]!=null){var L=l.y.vars[V].toString().length;if(L>=c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}}}A.y.maxVarLen=ag;A.y.maxVarChr=c;A.y.maxVarStr=aa;A.y.vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";if(!A.y.range){A.y.range={}}for(var V=0;Vag){ag=E;c=A[O].levels[V].toString().length;aa=A[O].levels[V]}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa}A[O].shapes=this.shapes;A[O].sizes=this.sizes;A[O].patterns=this.patterns}else{var S={};for(var V=0;Vag){ag=E;c=S[V].length;aa=S[V]}}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa;A[O].type="String";A[O].colors=[];var K=0;for(var V=0;V0){return true}else{if(a=="max"&&b.max&&b.max[0].length>0){return true}else{if(a=="min"&&b.min&&b.min[0].length>0){return true}else{if(a=="count"&&b.count&&b.count[0].length>0){return true}else{if(a=="mean"&&b.mean&&b.mean[0].length>0){return true}else{if(a=="median"&&b.median&&b.median[0].length>0){return true}else{if(a=="iqr"&&b.iqr1&&b.qtl1&&b.median&&b.qtl3&&b.iqr3&&b.median[0].length>0){return true}else{if(a=="raw"&&this.isRawData){return true}else{return false}}}}}}}}}}}}};this.we=function(aw,f,Q,ag,J){var W=this;var r=this.isDOE?this.data.l.data[this.layoutCurrent||0]:false;var t=this.isGroupedData&&!f&&this.data.w?this.data.w:this.data.y;var ah=this.graphType=="Scatter2D"&&this.scatterType=="visium"?CanvasXpress.cacheImages[this.backgroundImageMD5||this.va(this.backgroundImage)]:false;var w=this.Xs(true);var at=Number.POSITIVE_INFINITY;var K=Number.NEGATIVE_INFINITY;var A=Number.POSITIVE_INFINITY;var ab=Number.NEGATIVE_INFINITY;if(this.setMin!=null&&this.setMax!=null){this.minData=Number(this.setMin);this.maxData=Number(this.setMax);return}if(this.isGroupedData&&!aw&&!r){aw=this.graphType=="Boxplot"?"iqr":this.summaryType;if(this.graphType=="Boxplot"&&!this.isBoxplotCalc){this.cg(this.groupingFactors,false,false,false,true);t=this.data.w}}if(this.isGroupedData&&!f&&this.data.w&&!ag&&!r&&!this.layoutCurrent){for(var ak=0;ak=0?H:0;var Y=this.data.y.data[this.meterIndex];at=0;K=this.ob(Y,true)}else{if(w){var G=this.varIndices.length;for(var ak=0;ak=0){var ad=this.Ts(this.data.y.data[ap]);at=ad[0];K=ad[1]}else{at=0;K=1}}}else{if(aw=="gantt"){if(!this.data.gantt){this.isGanttDataFormated=false;this.ww()}var ak=this.as(this.ganttStart?this.ganttStart:this.xAxis[0]?this.xAxis[0]:this.data.y.vars[0]);this.ganttStart=this.data.y.vars[ak];var aj=this.as(this.ganttEnd?this.ganttEnd:this.xAxis[1]?this.xAxis[1]:this.data.y.vars[1]?this.data.y.vars[1]:this.data.y.vars[0]);this.ganttEnd=this.data.y.vars[aj]||this.data.y.vars[0];var ar=this.i4(this.data.gantt);at=ar[ak].sort(function(d,c){return d-c})[0];K=ar[aj].sort(function(d,c){return c-d})[0]}else{if(aw=="km"&&!f){if(!this.layoutValid){this.DO()}if(J=="y"){at=0;K=1}else{var ac=this.layoutValid&&this.meta.data.p.l.length?this.meta.data.p.l:this.meta.data.p.g;if(this.layoutValid&&this.meta.data.p.l.length){for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}}else{var G=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0){at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{if(Q){if(O>0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}}}}else{if(this.summaryType=="mean"&&!this.isRawData){var S=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0&&B>0){at=Math.min(D,at);K=Math.max(B,K)}}else{at=Math.min(D,at);K=Math.max(B,K)}}if(X){var T=X.length;for(var ai=0;ai0){at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}else{at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}}}}}}}else{if(aw=="cor"){var o=this.correlationAxis=="variables"?this.varIndices:this.isGroupedData?this.grpIndices:this.smpIndices;var S=o.length;for(var ak=0;ak0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}else{if(r){var C=J=="xAxis"?0:1;if(this.graphType=="Scatter2D"){for(var ak=0;ak0){if(ag){var V=this.graphType=="Circular"&&this.showIdeogram;var F=V?[this.varIndices,this.smpIndices]:[this.smpIndices,this.varIndices];var y=F[0].length;K=0;at=0;ab=0;A=0;for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}else{var S=this.motionBy||(this.isDOE&&this.isDOE==1)?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}if(this[J+"Transform"]=="sqrt"){at=Math.sqrt(at);K=Math.sqrt(K)}}}}}}}}}}}}}}}}}}}if(this.graphType=="Boxplot"&&this.showViolinBoxplot&&!this.violinTrim){var x=this.meta.data.d;if(this.isGroupedData){x=x.g;var S=x.length;for(var ak=0;ak1)&&!this.dataPointSizeScaleFactor&&this.scatterType=="stream"){if(J=="xAxis"){var I=(K-at)*this.scatterStreamExtraSpan;at-=I;K+=I}else{if(J=="yAxis"){this.b8();if(this.meta.data.s){var aa=this.layoutValid?this.meta.data.s.layout[this.layoutCurrent||0]:this.meta.data.s;switch(this.scatterStreamType){case"mirror":at=-aa.maxY;K=aa.maxY;break;case"ridge":at=0;K=aa.maxY*2;break;case"proportional":at=0;K=1;break}}}}}else{if(this.graphType=="Scatter2D"&&J=="yAxis"&&(this.showLoessFit||this.showRegressionFit||this.showQuantileRegressionFit)){if(this.showLoessFit){this.l1()}if(this.showRegressionFit){this.ba()}if(this.showQuantileRegressionFit){this.Tw()}if(this.meta.data.s){var af=this.meta.data.s;if(af.minY!=null&&af.minYNumber.NEGATIVE_INFINITY){if(this.dataPointSizeScaleFactor){at=Math.min(at,af.minY);K=Math.max(K,af.maxY)}else{at=af.minY;K=af.maxY}}}}}}}}}}if(this.decorations){if(this.decorations.error){for(var ak=0;ak=f&&d<=b))&&(e===null||(c>=e&&c<=a))){}else{if(q){this.filterFitIndices[q[h]]=true}else{this.filterFitIndices[r]=true}}}}for(var h=0;h=f&&d<=b))&&(e===null||(c>=e&&c<=a))){j.push(d);g.push(c)}}return[j,g]};this.WL=function(){var I=this;var K=[];var S=function(aw,an,aq){var aa=[];var aj=[];var q=aw.sets||[aw];var ah=0;if(!I.isDOE){for(var av=0;av0?aA[au][1]/ab.position.tot[au]:0);ae[au]=[ad.xy[au][0],ax[au]]}ab.filled[av]=ae.concat(ak.reverse())}if(aq!=null){var az=0;for(var av=0;av1&&I.meta.data.z&&I.meta.data.z.hasOwnProperty(I.segregateVariablesBy[1])){j=I.meta.data.z[I.segregateVariablesBy[1]].levels}}if(I.segregateSamplesBy.length){if(I.meta.data.z&&I.meta.data.z.hasOwnProperty(I.segregateSamplesBy[0])){aa=I.meta.data.z[I.segregateSamplesBy[0]].levels}else{if(I.segregateSamplesBy[0]=="sample"){aa=I.data.y.smps}}if(I.segregateSamplesBy.length>1&&I.meta.data.z&&I.meta.data.z.hasOwnProperty(I.segregateSamplesBy[1])){q=I.meta.data.z[I.segregateSamplesBy[1]].levels}}var k=(l.length||1)*(j.length||1)*(aa.length||1)*(q.length||1);if(ab.length&&ab.length==k){return true}else{return false}};var A=function(ag,ae){var ac=[];var ab=ae||I.segregateVariablesBy[ag];var aj=I.meta.data.z[ab].levels;var ap=I.data;if(!Z.hasOwnProperty("Factor")){Z.Factor={}}var ai=0;for(var am=0;amthis.maxDOENumber){break}}}else{for(var T=0;Tthis.maxDOENumber){break}}}o=true}}}else{if(this.graphType.match(/Scatter|Map/)){if(this.segregateVariablesBy.length&&this.meta.data.z&&this.meta.data.z.hasOwnProperty(this.segregateVariablesBy[0])){var Z=I.meta.data.s.density;var V=A(0);if(this.segregateVariablesBy.length==2||(this.showHistogram!=true&&this.showHistogram!=this.segregateVariablesBy[0])){var e=this.segregateVariablesBy.length==2?this.segregateVariablesBy[1]:this.showHistogram;var U=this.segregateVariablesBy.length==2?A(1):A(false,e);K=[];var h=this.meta.data.z[this.segregateVariablesBy[0]].levels;var f=this.meta.data.z[e].levels;var X=this.data;var N=0;for(var T=0;T5){try{b.loess[o+":"+h[d]]=this.Ed([q[0],q[1]],"Loess:"+o+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.loess[o+":"+h[d]].range[3])}catch(c){f.push(["setLoessData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.loess[o]=this.Ed([q[0],q[1]],"Global:"+o+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o].range[2]);b.maxY=Math.max(b.maxY,b.loess[o].range[3])}catch(c){f.push(["setLoessData",q[0].length,o,c])}}}}}};this.ba=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={regression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("regression")){this.meta.data.s.regression={}}}if(this.layoutValid&&this.meta.data.s.layout&&this.data.l&&this.data.l.comp&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e3){b.regression[p+":"+h[c]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[c]);b.minY=Math.min(b.minY,b.regression[p+":"+h[c]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[c]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[c],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,e,d,o);if(s[0].length>3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}else{for(var e=0;e3){b.regression[p+":"+h[d]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p+":"+h[d]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[d]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[d],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,l,r,o);if(s[0].length>=3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}};this.Tw=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={quantileRegression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("quantileRegression")){this.meta.data.s.quantileRegression={}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e5){try{b.quantileRegression[o+":"+h[d]]=this.Sm(q[0],q[1],this.quantiles,"QuantileRegression:"+o+":"+h[d]+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o+":"+h[d]])){b.minY=Math.min(b.minY,b.quantileRegression[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o+":"+h[d]].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.quantileRegression[o]=this.Sm(q[0],q[1],this.quantiles,"Global:"+o+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o])){b.minY=Math.min(b.minY,b.quantileRegression[o].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o,c])}}}}}};this.yc=function(b,o){if(!b){if(!this.meta.data.s||(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length)){if(!this.meta.data.s){this.meta.data.s={areas:{},layout:[]}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var f=0;f=0){t[0].push(l[r]);t[1].push(d[r]);s=r}else{if(e==0){t[0].push(h[e]);t[1].push(h[e]=0){g[0].push(r[q]);g[1].push(E[q])}else{g[0].push(k[w]);g[1].push(0)}}if(r.length>5){this.loessSpan=this.scatterStreamBandwidth?Math.max(0.1,this.scatterStreamBandwidth-0.45):0.3;try{var t=this.Ed([g[0],g[1]],"Stream"+s[y]+(D!=null?D:""));for(var w=0;w0){this.Ab();for(var c=0;c=1000){alert("Cannot exp transform values > 1000");return false}e=e=="exp2"?"exp2":"exp10"}}if(!g.trans){g.trans=[]}if(!g.tstdev){g.tstdev=[]}var f=this.motionBy?this.data.y.vars.length:this.isGroupedData?this.data.y.vars.length:!this.isDOE?this.data.y.vars.length:this.varIndices.length;for(var c=0;c0){var c=this.transformBase==2?"ratio2":"ratio10";var z=a.data[k][s]/e;var d=a.stdev[k][s];if(c=="ratio2"){a.trans[k][s]=Math.log(z)/Math.LN2;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN2}}else{if(c=="ratio10"){a.trans[k][s]=Math.log(z)/Math.LN10;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN10}}}}}}};this.Ph=function(s,p,o){var c=this.isGroupedData&&!this.graphType.match(/dotplot|boxplot/i)?this.data.w:this.data.y;var k=this.isGroupedData?false:true;var q;p=p?p:this.transformAxis;if(p=="samples"){for(var g=0;g1&&ah.includes("__FACTOR__")){ah=ah.filter(function(a){return a!="__FACTOR__"})}for(var Y=0;Y0?q.join(" :: "):"";if(!w.hasOwnProperty(B)){af.w.smps.push(B);P[B]=U;w[B]=[]}w[B].push(y)}this.isGroupedData=true;if(af.w.smps.length<1){af.w.smps=z;this.H9({func:"groupSamples",par:[ah,R,r,ac,c,C,ai]});return}if(this.isCxplot&&ah.length==1&&this.meta.data.x&&this.meta.data.x.hasOwnProperty(ah[0])&&this.meta.data.x[ah[0]].levels&&this.meta.data.x[ah[0]].type!="Numeric"){if(this.sortIncludeEmpty){if(this.meta.config.user.aes.hasOwnProperty("meta")){if(ah[0]==this.meta.config.user.aes.x&&this.meta.config.user.aes.meta.hasOwnProperty("xLabels")){var Z=this.eI(this.meta.config.user.aes.meta.xLabels);var ab=false;for(var Y=0;Y360){this.circularArc=360}else{if(this.circularArc<90){this.circularArc=90}}var y=this.circularArc*(Math.PI*2)/360;var p=(y-this.So(this.circularArcSectorSeparation)*(this.circularArc==360?B:B-1))/k;var h=[];var f=[];var C=0;for(var F=0;F=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}this.FV("y");this.YS(true,true);this.aS()}if(!c){this.H9({func:"uncountData",par:[]})}};this.K6=function(b,e){if(b){this.data.y.smps.push("__SEQ__");for(var a=0;a=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}}this.FV("y");this.YS(true,true);this.aS();if(!c){this.H9({func:"unsequenceData",par:[]})}};this.qR=function(){var u=this.isDOE?this.data.l.data[this.layoutCurrent]:false;var g=this.isDOE?u.y.data[0]:this.eI(this.data.y.data[this.meterIndex]);var t=this.isDOE?u.y.meter.group:this.groupingFactors.length?this.groupingFactors[0]:false;var e=this.isDOE?u.x[t]:t?this.eI(this.data.x[t]):false;var h=this.isDOE?u.y.meter.summary:this.summaryType;var c=this.isDOE?u.y.meter.topology:this.meterTopology;var p=t&&(!this.isDOE||this.isDOE==1)?this.meta.data.x[t]:t&&this.isDOE>1?this.meta.data.z[t]:false;var j=this.isDOE&&this.isDOE>1?this.varIndices:this.smpIndices;this.isMeterSummarized={data:g,count:g.length,sum:this.XX(g),mean:this.nd(g),max:this.ob(g)};var q=this.isMeterSummarized;var a=this.rangeSegments.length&&!this.isDOE?this.rangeSegments[this.rangeSegments.length-1]:false;switch(h){case"count":case"countTotal":q.value=q.count;q.scale=this[this.axisAlgorithm](0,a||q.count,5,false,this.axisWilkinsonLoose);q.reference=q.count;break;case"average":case"mean":case"raw":q.value=q.mean;q.scale=this[this.axisAlgorithm](0,a||q.max,5,false,this.axisWilkinsonLoose);q.reference=q.max;break;case"sum":case"sumTotal":q.value=q.sum;q.scale=this[this.axisAlgorithm](0,a||q.sum,5,false,this.axisWilkinsonLoose);q.reference=q.sum;break;case"percentage":case"percentageTotal":q.value=100;q.scale=this[this.axisAlgorithm](0,a||100,5,false,this.axisWilkinsonLoose);q.reference=100;break}q.range=a||q.scale[q.scale.length-1];var k=this.TM();var b=this.isDOE?this.layoutWidth:this.width-(this.marginLeft+this.marginRight);var o=(this.isDOE?this.layoutHeight:this.height)-(k+this.marginTop+this.marginBottom);if(t){if(p&&p.type=="String"){q.n=p.levels.length;let ratio=b/o;let inverseRatio=o/b;let condition=q.n<2&&c=="auto";let condition2=c=="auto"&&ratio>q.n-0.5;let condition3=c=="auto"&&inverseRatio>q.n-0.5;let condition4=c=="horizontal";let condition5=c=="vertical";if(condition||condition2||condition4){q.cols=q.n;q.rows=1}else{if(condition3||condition5){q.cols=1;q.rows=q.n}else{q.cols=Math.ceil(Math.sqrt(q.n));q.rows=Math.ceil(q.n/q.cols)}}q[t]={};q.levels=p.levels;for(var f=0;f0){l[g]++}}}if(!this.data.x){this.data.x={}}this.data.x.Sets=l;a=a.sort(function(s,j){return l[j]-l[s]});if(!this.upSetSets.length){a=a.splice(0,this.nUpSets)}this.isUpSetSumarized.vars=this.eI(a.reverse());a=this.iT(a);var b=[];var o=[];var r=[];var c=[];var e={};var h={};var k=[];for(var g=0;g0){b[g]++;if(a.hasOwnProperty(f)){o.push(f)}}}var q=o.join(":");if(!e.hasOwnProperty(q)){e[q]=[]}e[q].push(g)}this.isUpSetSumarized.inter=e;var p=[];for(var g in e){var d=g.split(":").length;h[g]=e[g].length;if(g!=""){p.push(g)}for(var f=0;f0){var k=[];var g=[];for(var h=0;h0){}this.treemapBy=k}var p=this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Map|Circular/)||this.graphType=="Tree";if(this.shapeBy&&!this.isMultidimensionalData&&!p){c+="shapeBy changed to false (shapeBy not support in"+this.graphType+")\n";this.shapeBy=false}else{if(this.shapeBy&&this.groupingFactors.length>1&&!p){c+="shapeBy changed to variable (multiple grouping factors not allowed)\n";this.shapeBy="variable"}else{if(this.shapeBy&&this.groupingFactors.length==1&&this.shapeBy!=this.groupingFactors[0]&&!p){c+="shapeBy changed to variable (grouping factor should the same as shapeBy)\n";this.shapeBy="variable"}}}if(this.sizeBy&&!this.isMultidimensionalData&&!p){c+="sizeBy changed to false (sizeBy not support in"+this.graphType+")\n";this.sizeBy=false}else{if(this.sizeBy&&this.groupingFactors.length>1&&!p){c+="sizeBy changed to variable (multiple grouping factors not allowed)\n";this.sizeBy="variable"}else{if(this.sizeBy&&this.groupingFactors.length==1&&this.sizeBy!=this.groupingFactors[0]&&!p){c+="sizeBy changed to variable (grouping factor should the same as sizeBy)\n";this.sizeBy="variable"}}}if(this.colorBy&&this.graphType=="Heatmap"&&!this.isMultidimensionalData){this.lX(this.colorBy)}else{if(this.graphType=="Heatmap"&&this.heatmapType=="split"&&b){this.cq()}else{if(this.colorBy&&this.groupingFactors.length>1&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap/)&&!this.isCxplot){c+="colorBy changed to variable (multiple grouping factors not allowed)\n";this.colorBy="variable"}else{if(this.colorBy&&this.groupingFactors.length==1&&this.colorBy!=this.groupingFactors[0]&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap|Line/)&&this.barType!="swimmer"){if(this.toDoPivot){this.colorBy=false}else{c+="colorBy changed to variable (grouping factor should the same as colorBy)\n";this.colorBy="variable"}}}}}if((this.shapeBy||this.sizeBy||this.patternBy||this.outlineBy)&&!this.colorBy&&!this.isMultidimensionalData&&!this.graphType=="Heatmap"&&!this.isCxplot){this.colorBy="variable"}else{if(!this.shapeBy&&!this.sizeBy&&!this.patternBy&&this.colorBy=="variable"&&this.graphType!="Map"){this.colorBy=o()}}if(this.shapeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.sizeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.patternBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.stackBy&&!this.colorBy){this.colorBy=this.stackBy}else{if(this.stackBy&&this.colorBy&&this.stackBy!=this.colorBy){c+="colorBy changed to stackBy (remove stackBy to color by different factor)\n";this.colorBy=this.stackBy}}if(this.dodgeBy&&!this.colorBy){this.colorBy=this.dodgeBy}else{if(this.dodgeBy&&this.colorBy&&this.dodgeBy!=this.colorBy){c+="colorBy changed to dodgeBy (remove dodgeBy to color by different factor)\n";this.colorBy=this.dodgeBy}}if(this.lineBy&&!this.colorBy&&this.isGroupedData){}else{if(this.lineBy&&this.colorBy&&this.lineBy!=this.colorBy&&this.isGroupedData){c+="colorBy changed to lineBy (remove lineBy to color by different factor)\n";this.colorBy=this.lineBy}else{if(this.lineBy&&!this.isGroupedData&&this.graphType!="Scatter2D"){c+="Data needs to be grouped";this.lineBy=false}}}if(c!=""){this.n6(10,10,c,3000)}if(this.colorBy||this.shapeBy||this.sizeBy||this.lineBy){var q=["colorBy","shapeBy","lineBy"];var t=[];for(var h=0;h=0&&o.w.grps[E]){for(var g=0;g1){return false}}}return true};var f=function(){if(!e.patternBy){if(G>e.colors.length-1&&!e.colorBy){return e[z[F]][Math.floor(G/e.colors.length)]}else{return e[z[F]][0]}}else{return e[z[F]][0]}};var r=F&&this[z[F]]?this[z[F]].length:false;if(G!=null&&E!=null&&u&&o.y.hasOwnProperty(u)){y=o.y[u][G][E];x=H[u];j=x.type}else{if(E!=null&&u&&o.x&&o.x.hasOwnProperty(u)){x=H.x[u];if(C||!this.isGroupedData){j=x.type;y=this.graphType=="Gantt"?o.x[u][E]:this.isGroupedData?o.w.smps[E]:o.x[u][E];if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(F=="colorSmpDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}}}else{if((A&&(this.groupingFactors[0]==u||d()))||(!A&&this.isGroupedData&&this.isCxplot&&this.groupingFactors.length>1)){j=x.type;y=E!==false&&E>=0&&o.w.grps[E]?o.x[u][o.w.grps[E][0]]:false;if(y&&F.match(/color|patternBy/)){if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(x[z[F]]){return x[z[F]][x.order[y]%r]}else{return this[z[F]][x.order[y]%r]}}}else{return x[z[F]]?x[z[F]][0]:F.match(/color/)?this[z[F]][0]:F=="patternBy"?f():this[z[F]][0]}}else{return G!=null&&F.match(/color/)?this[z[F]][G%r]:F=="patternBy"?f():this[z[F]][0]}}}else{if(G!=null&&u&&o.z&&o.z.hasOwnProperty(u)){x=H.z[u];j=x.type;y=o.z[u][G];if(x[F]&&(x[F].hasOwnProperty(y)||x[F][y])){return x[F][y]}else{if(x[F]&&(x[F].hasOwnProperty(y+"\x00")||x[F][y+"\x00"])){return x[F][y+"\x00"]}else{if(x[F]&&x[F][y.replace("\x00","")]){return x[F][y.replace("\x00","")]}else{if(F=="colorVarDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}else{if(x[F]&&F=="linePatterns"&&x.order&&x.order.hasOwnProperty(y)){return x[F][x.order[y]%this[F].length]}}}}}}else{if(G!=null&&E!=null&&F&&((this.isGroupedData&&H.w.smps.hasOwnProperty(F))||(!this.isGroupedData&&H.y.range.hasOwnProperty(F)))){y=o.y.data[G][E];x=H.y.range[F];j=H.y.type}else{if(G!=null&&!this.isGroupedData&&u&&H.y.range.hasOwnProperty(u)){x=H.y.range[u];j=x.type;k=E!=null?false:this.sF(u);y=E!=null?o.y.data[G][E]:o.y.data[G]?o.y.data[G][k>=0?k:0]:0;if(H.modified&&H.modified.z&&H.modified.z[u]){return 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a=c.toLowerCase().replace(/ /g,"");switch(a){case"grey":case"gray":case"igray":case"ggplot":return CanvasXpress.themeDef.grey;case"bw":case"blackandwhite":return CanvasXpress.themeDef.bw;case"linedraw":return CanvasXpress.themeDef.linedraw;case"light":return CanvasXpress.themeDef.light;case"dark":return CanvasXpress.themeDef.dark;case"minimal":return CanvasXpress.themeDef.minimal;case"classic":return CanvasXpress.themeDef.classic;case"void":case"void0":return CanvasXpress.themeDef.void0;case"economist":return CanvasXpress.themeDef.economist;case"excel":return CanvasXpress.themeDef.excel;case"solarized":return CanvasXpress.themeDef.solarized;case"paulTol":case"paultol":case"ptol":return CanvasXpress.themeDef.ptol;case"highcharts":return CanvasXpress.themeDef.highcharts;case"wallstreetjournal":case"wallstreet":case"wsj":return CanvasXpress.themeDef.wsj;case"tableau":return CanvasXpress.themeDef.tableau;case"stata":return CanvasXpress.themeDef.stata;case"ggblanket":return CanvasXpress.themeDef.ggblanket;case"cx":case"canvasxpress":return CanvasXpress.themeDef.cx;case"cxdark":case"canvasxpressdark":return CanvasXpress.themeDef.cxdark;case"cx2":case"canvasxpresstraditional":return CanvasXpress.themeDef.grey;default:var b=this.eI(CanvasXpress.themeDef.light);b["panel.border.colour"]=null;return b}};this.L3=function(b){if(!b){b="x"}var e=["AxisShow","Axis2Show","AxisTitleColor","AxisTitleScaleFontFactor","AxisTextColor","AxisTextScaleFontFactor","AxisTicksShow","AxisTicksColor","AxisTicksLength","AxisTicksWidth","AxisLineBottomShow","AxisLineBottomColor","AxisLineBottomLineType","AxisLineBottomWidth","AxisLineTopShow","AxisLineTopColor","AxisLineTopLineType","AxisLineTopWidth","AxisGridMajorShow","AxisGridMajorColor","AxisGridMajorLineType","AxisGridMajorWidth","AxisGridMinorShow","AxisGridMinorColor","AxisGridMinorLineType","AxisGridMinorWidth"];var f=["r","z"];for(var d=0;d0&&!this.skipTransition&&this.showTransition){delete 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e&&e.classList?e.classList.contains(n):false};this.X0=function(e,n){if(e){e.classList.add(n)}};this.Tg=function(e,n){if(e){e.classList.remove(n)}};this.Rs=function(e,r,a){if(e){e.classList.remove(r);e.classList.add(a)}};this.md=function(e){var s="";var o=getComputedStyle(e);for(var i=0;i0?1:-1)*Math.floor(Math.abs(number))};var maxSafeInteger=Math.pow(2,53)-1;var toLength=function(value){var len=toInteger(value);return Math.min(Math.max(len,0),maxSafeInteger)};return function from(arrayLike){var C=this;var items=Object(arrayLike);if(arrayLike==null){throw new TypeError("Array.from requires an array-like object - not null or undefined")}var mapFn=arguments.length>1?arguments[1]:void undefined;var T;if(typeof mapFn!=="undefined"){if(!isCallable(mapFn)){throw new TypeError("Array.from: when provided, the second argument must be a function")}if(arguments.length>2){T=arguments[2]}}var len=toLength(items.length);var A=isCallable(C)?Object(new C(len)):new Array(len);var k=0;var kValue;while(k>>0;var start=arguments[1];var relativeStart=start>>0;var k=relativeStart<0?Math.max(len+relativeStart,0):Math.min(relativeStart,len);var end=arguments[2];var relativeEnd=end===undefined?len:end>>0;var finl=relativeEnd<0?Math.max(len+relativeEnd,0):Math.min(relativeEnd,len);while(k>>0;if(typeof callback!=="function"){throw new TypeError(callback+" is not a function")}if(arguments.length>1){T=arguments[1]}A=new Array(len);k=0;while(k>>0;if(typeof predicate!=="function"){throw new TypeError("predicate must be a function")}var thisArg=arguments[1];var k=0;while(k>>0;if(len===0){return false}var n=fromIndex|0;var k=Math.max(n>=0?n:len-Math.abs(n),0);function sameValueZero(x,y){return x===y||(typeof x==="number"&&typeof y==="number"&&isNaN(x)&&isNaN(y))}while(kA){var G=A;A=u;u=G}}var o=this.Fe(u,A,4);u=o[0];A=o[o.length-1];var y=A-u;var a=(((y*1000000)-(parseInt(y)*1000000))/1000000).toString().replace(/\./,"").length-1;var e=Math.pow(1/10,(a+1));var C=u>0?Math.log10(u):u==0?0:null;var E=A>0?Math.log10(A):A==0?0:null;var c=[];var Q="CanvasXpressRangeSlider";if(C!=null&&E!=null){var I=this.Fe(C,E,4);for(var B=0;B1){m=l;m.width=arguments[0];m.height=arguments[1]}else{if(!n){m=l}else{m=n}}if(!(this instanceof k)){return new k(m)}this.width=m.width||l.width;this.height=m.height||l.height;this.desc=m.desc||l.desc;this.enableMirroring=m.enableMirroring!==undefined?m.enableMirroring:l.enableMirroring;this.canvas=this;this.__document=m.document||document;if(m.ctx){this.__ctx=m.ctx}else{this.__canvas=this.__document.createElement("canvas");this.__ctx=this.__canvas.getContext("2d")}this.__setDefaultStyles();this.__stack=[this.__getStyleState()];this.__groupStack=[];this.__root=this.__document.createElementNS("http://www.w3.org/2000/svg","svg");this.__root.setAttribute("version",1.1);this.__root.setAttribute("xmlns","http://www.w3.org/2000/svg");this.__root.setAttributeNS("http://www.w3.org/2000/xmlns/","xmlns:xlink","http://www.w3.org/1999/xlink");this.__root.setAttribute("width",this.width);this.__root.setAttribute("height",this.height);this.__root.setAttribute("desc",this.desc);this.__ids={};this.__defs=this.__document.createElementNS("http://www.w3.org/2000/svg","defs");this.__root.appendChild(this.__defs);this.__currentElement=this.__document.createElementNS("http://www.w3.org/2000/svg","g");this.__root.appendChild(this.__currentElement)};k.prototype.__createElement=function(l,p,r){if(typeof 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normal; + line-height: 1; + text-rendering: auto; } + +.fas, +.fa-classic, +.fa-solid, +.far, +.fa-regular { + font-family: 'Font Awesome 6 Free'; } + +.fab, +.fa-brands { + font-family: 'Font Awesome 6 Brands'; } + +.fa-1x { + font-size: 1em; } + +.fa-2x { + font-size: 2em; } + +.fa-3x { + font-size: 3em; } + +.fa-4x { + font-size: 4em; } + +.fa-5x { + font-size: 5em; } + +.fa-6x { + font-size: 6em; } + +.fa-7x { + font-size: 7em; } + +.fa-8x { + font-size: 8em; } + +.fa-9x { + font-size: 9em; } + +.fa-10x { + font-size: 10em; } + +.fa-2xs { + font-size: 0.625em; + line-height: 0.1em; + vertical-align: 0.225em; } + +.fa-xs { + font-size: 0.75em; + line-height: 0.08333em; + vertical-align: 0.125em; } + +.fa-sm { + font-size: 0.875em; + line-height: 0.07143em; + vertical-align: 0.05357em; } + +.fa-lg { + font-size: 1.25em; + line-height: 0.05em; + vertical-align: -0.075em; } + +.fa-xl { + font-size: 1.5em; + line-height: 0.04167em; + vertical-align: -0.125em; } + +.fa-2xl { + font-size: 2em; + line-height: 0.03125em; + vertical-align: -0.1875em; } + +.fa-fw { + text-align: center; + width: 1.25em; } + +.fa-ul { + list-style-type: none; + margin-left: var(--fa-li-margin, 2.5em); + padding-left: 0; } + .fa-ul > li { + position: relative; } + +.fa-li { + left: calc(var(--fa-li-width, 2em) * -1); + position: absolute; + text-align: center; + width: var(--fa-li-width, 2em); + line-height: inherit; } + +.fa-border { + border-color: var(--fa-border-color, #eee); + border-radius: var(--fa-border-radius, 0.1em); + border-style: var(--fa-border-style, solid); + border-width: var(--fa-border-width, 0.08em); + padding: var(--fa-border-padding, 0.2em 0.25em 0.15em); } + +.fa-pull-left { + float: left; + margin-right: var(--fa-pull-margin, 0.3em); } + +.fa-pull-right { + float: right; + margin-left: var(--fa-pull-margin, 0.3em); } + +.fa-beat { + -webkit-animation-name: fa-beat; + animation-name: fa-beat; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out); + animation-timing-function: var(--fa-animation-timing, ease-in-out); } + +.fa-bounce { + -webkit-animation-name: fa-bounce; + animation-name: fa-bounce; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1)); + animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1)); } + +.fa-fade { + -webkit-animation-name: fa-fade; + animation-name: fa-fade; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); + animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); } + +.fa-beat-fade { + -webkit-animation-name: fa-beat-fade; + animation-name: fa-beat-fade; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); + animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); } + +.fa-flip { + -webkit-animation-name: fa-flip; + animation-name: fa-flip; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out); + animation-timing-function: var(--fa-animation-timing, ease-in-out); } + +.fa-shake { + -webkit-animation-name: fa-shake; + animation-name: fa-shake; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, linear); + animation-timing-function: var(--fa-animation-timing, linear); } + +.fa-spin { + -webkit-animation-name: fa-spin; + animation-name: fa-spin; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 2s); + animation-duration: var(--fa-animation-duration, 2s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, linear); + animation-timing-function: var(--fa-animation-timing, linear); } + +.fa-spin-reverse { + --fa-animation-direction: reverse; } + +.fa-pulse, +.fa-spin-pulse { + -webkit-animation-name: fa-spin; + animation-name: fa-spin; + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, steps(8)); + animation-timing-function: var(--fa-animation-timing, steps(8)); } + +@media (prefers-reduced-motion: reduce) { + .fa-beat, + .fa-bounce, + .fa-fade, + .fa-beat-fade, + .fa-flip, + .fa-pulse, + .fa-shake, + .fa-spin, + .fa-spin-pulse { + -webkit-animation-delay: -1ms; + animation-delay: -1ms; + -webkit-animation-duration: 1ms; + animation-duration: 1ms; + -webkit-animation-iteration-count: 1; + animation-iteration-count: 1; + -webkit-transition-delay: 0s; + transition-delay: 0s; + -webkit-transition-duration: 0s; + transition-duration: 0s; } } + +@-webkit-keyframes fa-beat { + 0%, 90% { + -webkit-transform: scale(1); + transform: scale(1); } + 45% { + -webkit-transform: scale(var(--fa-beat-scale, 1.25)); + transform: scale(var(--fa-beat-scale, 1.25)); } } + +@keyframes fa-beat { + 0%, 90% { + -webkit-transform: scale(1); + transform: scale(1); } + 45% { + -webkit-transform: scale(var(--fa-beat-scale, 1.25)); + transform: scale(var(--fa-beat-scale, 1.25)); } } + +@-webkit-keyframes fa-bounce { + 0% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 10% { + -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); + transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); } + 30% { + -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); + transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); } + 50% { + -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); + transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); } + 57% { + -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); + transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); } + 64% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 100% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } } + +@keyframes fa-bounce { + 0% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 10% { + -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); + transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); } + 30% { + -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); + transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); } + 50% { + -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); + transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); } + 57% { + -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); + transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); } + 64% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 100% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } } + +@-webkit-keyframes fa-fade { + 50% { + opacity: var(--fa-fade-opacity, 0.4); } } + +@keyframes fa-fade { + 50% { + opacity: var(--fa-fade-opacity, 0.4); } } + +@-webkit-keyframes fa-beat-fade { + 0%, 100% { + opacity: var(--fa-beat-fade-opacity, 0.4); + -webkit-transform: scale(1); + transform: scale(1); } + 50% { + opacity: 1; + -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125)); + transform: scale(var(--fa-beat-fade-scale, 1.125)); } } + +@keyframes fa-beat-fade { + 0%, 100% { + opacity: var(--fa-beat-fade-opacity, 0.4); + -webkit-transform: scale(1); + transform: scale(1); } + 50% { + opacity: 1; + -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125)); + transform: scale(var(--fa-beat-fade-scale, 1.125)); } } + +@-webkit-keyframes fa-flip { + 50% { + -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); + transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } } + +@keyframes fa-flip { + 50% { + -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); + transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } } + +@-webkit-keyframes fa-shake { + 0% { + -webkit-transform: rotate(-15deg); + transform: rotate(-15deg); } + 4% { + -webkit-transform: rotate(15deg); + transform: rotate(15deg); } + 8%, 24% { + -webkit-transform: rotate(-18deg); + transform: rotate(-18deg); } + 12%, 28% { + -webkit-transform: rotate(18deg); + transform: rotate(18deg); } + 16% { + -webkit-transform: rotate(-22deg); + transform: rotate(-22deg); } + 20% { + -webkit-transform: rotate(22deg); + transform: rotate(22deg); } + 32% { + -webkit-transform: rotate(-12deg); + transform: rotate(-12deg); } + 36% { + -webkit-transform: rotate(12deg); + transform: rotate(12deg); } + 40%, 100% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } } + +@keyframes fa-shake { + 0% { + -webkit-transform: rotate(-15deg); + transform: rotate(-15deg); } + 4% { + -webkit-transform: rotate(15deg); + transform: rotate(15deg); } + 8%, 24% { + -webkit-transform: rotate(-18deg); + transform: rotate(-18deg); } + 12%, 28% { + -webkit-transform: rotate(18deg); + transform: rotate(18deg); } + 16% { + -webkit-transform: rotate(-22deg); + transform: rotate(-22deg); } + 20% { + -webkit-transform: rotate(22deg); + transform: rotate(22deg); } + 32% { + -webkit-transform: rotate(-12deg); + transform: rotate(-12deg); } + 36% { + -webkit-transform: rotate(12deg); + transform: rotate(12deg); } + 40%, 100% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } } + +@-webkit-keyframes fa-spin { + 0% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } + 100% { + -webkit-transform: rotate(360deg); + transform: rotate(360deg); } } + +@keyframes fa-spin { + 0% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } + 100% { + -webkit-transform: rotate(360deg); + transform: rotate(360deg); } } + +.fa-rotate-90 { + -webkit-transform: rotate(90deg); + transform: rotate(90deg); } + +.fa-rotate-180 { + -webkit-transform: rotate(180deg); + transform: rotate(180deg); } + +.fa-rotate-270 { + -webkit-transform: rotate(270deg); + transform: rotate(270deg); } + +.fa-flip-horizontal { + -webkit-transform: scale(-1, 1); + transform: scale(-1, 1); } + +.fa-flip-vertical { + -webkit-transform: scale(1, -1); + transform: scale(1, -1); } + +.fa-flip-both, +.fa-flip-horizontal.fa-flip-vertical { + -webkit-transform: scale(-1, -1); + transform: scale(-1, -1); } + +.fa-rotate-by { + -webkit-transform: rotate(var(--fa-rotate-angle, 0)); + transform: rotate(var(--fa-rotate-angle, 0)); } + +.fa-stack { + display: inline-block; + height: 2em; + line-height: 2em; + position: relative; + vertical-align: middle; + width: 2.5em; } + +.fa-stack-1x, +.fa-stack-2x { + left: 0; + position: absolute; + text-align: center; + width: 100%; + z-index: var(--fa-stack-z-index, auto); } + +.fa-stack-1x { + line-height: inherit; } + +.fa-stack-2x { + font-size: 2em; } + +.fa-inverse { + color: var(--fa-inverse, #fff); } + +/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen +readers do not read off random characters that represent icons */ + +.fa-0::before { + content: "\30"; } + +.fa-1::before { + content: "\31"; } + +.fa-2::before { + content: "\32"; } + +.fa-3::before { + content: "\33"; } + +.fa-4::before { + content: "\34"; } + +.fa-5::before { + content: "\35"; } + +.fa-6::before { + content: "\36"; } + +.fa-7::before { + content: "\37"; } + +.fa-8::before { + content: "\38"; } + +.fa-9::before { + content: "\39"; } + +.fa-fill-drip::before { + content: "\f576"; } + +.fa-arrows-to-circle::before { + content: "\e4bd"; } + +.fa-circle-chevron-right::before { + content: "\f138"; } + +.fa-chevron-circle-right::before { + content: "\f138"; } + +.fa-at::before { + content: "\40"; } + +.fa-trash-can::before { + content: "\f2ed"; } + +.fa-trash-alt::before { + content: "\f2ed"; } + +.fa-text-height::before { + content: "\f034"; } + +.fa-user-xmark::before { + content: "\f235"; } + +.fa-user-times::before { + content: "\f235"; } + +.fa-stethoscope::before { + content: "\f0f1"; } + +.fa-message::before { + content: "\f27a"; } + +.fa-comment-alt::before { + content: "\f27a"; } + +.fa-info::before { + content: "\f129"; } + +.fa-down-left-and-up-right-to-center::before { + content: "\f422"; } + +.fa-compress-alt::before { + content: "\f422"; } + +.fa-explosion::before { + content: "\e4e9"; } + +.fa-file-lines::before { + content: "\f15c"; } + +.fa-file-alt::before { + content: "\f15c"; } + +.fa-file-text::before { + content: "\f15c"; } + +.fa-wave-square::before { + content: "\f83e"; } + +.fa-ring::before { + content: "\f70b"; } + +.fa-building-un::before { + content: "\e4d9"; } + +.fa-dice-three::before { + content: "\f527"; } + +.fa-calendar-days::before { + content: "\f073"; } + +.fa-calendar-alt::before { + content: "\f073"; } + +.fa-anchor-circle-check::before { + content: "\e4aa"; } + +.fa-building-circle-arrow-right::before { + content: "\e4d1"; } + +.fa-volleyball::before { + content: "\f45f"; } + +.fa-volleyball-ball::before { + content: "\f45f"; } + +.fa-arrows-up-to-line::before { + content: "\e4c2"; } + +.fa-sort-down::before { + content: "\f0dd"; } + +.fa-sort-desc::before { + content: "\f0dd"; } + +.fa-circle-minus::before { + content: "\f056"; } + +.fa-minus-circle::before { + content: "\f056"; } + +.fa-door-open::before { + content: "\f52b"; } + +.fa-right-from-bracket::before { + content: "\f2f5"; } + +.fa-sign-out-alt::before { + content: "\f2f5"; } + +.fa-atom::before { + content: "\f5d2"; } + +.fa-soap::before { + content: "\e06e"; } + +.fa-icons::before { + content: "\f86d"; } + +.fa-heart-music-camera-bolt::before { + content: "\f86d"; } + +.fa-microphone-lines-slash::before { + content: "\f539"; } + +.fa-microphone-alt-slash::before { + content: "\f539"; } + +.fa-bridge-circle-check::before { + content: "\e4c9"; } + +.fa-pump-medical::before { + content: "\e06a"; } + +.fa-fingerprint::before { + content: "\f577"; } + +.fa-hand-point-right::before { + content: "\f0a4"; } + +.fa-magnifying-glass-location::before { + content: "\f689"; } + +.fa-search-location::before { + content: "\f689"; } + +.fa-forward-step::before { + content: "\f051"; } + +.fa-step-forward::before { + content: "\f051"; } + +.fa-face-smile-beam::before { + content: "\f5b8"; } + +.fa-smile-beam::before { + content: "\f5b8"; } + +.fa-flag-checkered::before { + content: "\f11e"; } + +.fa-football::before { + content: "\f44e"; } + +.fa-football-ball::before { + content: "\f44e"; } + +.fa-school-circle-exclamation::before { + content: "\e56c"; } + +.fa-crop::before { + content: "\f125"; } + +.fa-angles-down::before { + content: "\f103"; } + +.fa-angle-double-down::before { + content: "\f103"; } + +.fa-users-rectangle::before { + content: "\e594"; } + +.fa-people-roof::before { + content: "\e537"; } + +.fa-people-line::before { + content: "\e534"; } + +.fa-beer-mug-empty::before { + content: "\f0fc"; } + +.fa-beer::before { + content: "\f0fc"; } + +.fa-diagram-predecessor::before { + content: "\e477"; } + +.fa-arrow-up-long::before { + content: "\f176"; } + +.fa-long-arrow-up::before { + content: "\f176"; } + +.fa-fire-flame-simple::before { + content: "\f46a"; } + +.fa-burn::before { + content: "\f46a"; } + +.fa-person::before { + content: "\f183"; } + +.fa-male::before { + content: "\f183"; } + +.fa-laptop::before { + content: "\f109"; } + +.fa-file-csv::before { + content: "\f6dd"; } + +.fa-menorah::before { + content: "\f676"; } + +.fa-truck-plane::before { + content: "\e58f"; } + +.fa-record-vinyl::before { + content: "\f8d9"; } + +.fa-face-grin-stars::before { + content: "\f587"; } + +.fa-grin-stars::before { + content: "\f587"; } + +.fa-bong::before { + content: "\f55c"; } + +.fa-spaghetti-monster-flying::before { + content: "\f67b"; } + +.fa-pastafarianism::before { + content: "\f67b"; } + +.fa-arrow-down-up-across-line::before { + content: "\e4af"; } + +.fa-spoon::before { + content: "\f2e5"; } + +.fa-utensil-spoon::before { + content: "\f2e5"; } + +.fa-jar-wheat::before { + content: "\e517"; } + +.fa-envelopes-bulk::before { + content: "\f674"; } + +.fa-mail-bulk::before { + content: "\f674"; } + +.fa-file-circle-exclamation::before { + content: "\e4eb"; } + +.fa-circle-h::before { + content: "\f47e"; } + +.fa-hospital-symbol::before { + content: "\f47e"; } + +.fa-pager::before { + content: "\f815"; } + +.fa-address-book::before { + content: "\f2b9"; } + +.fa-contact-book::before { + content: "\f2b9"; } + +.fa-strikethrough::before { + content: "\f0cc"; } + +.fa-k::before { + content: "\4b"; } + +.fa-landmark-flag::before { + content: "\e51c"; } + +.fa-pencil::before { + content: "\f303"; } + +.fa-pencil-alt::before { + content: "\f303"; } + +.fa-backward::before { + content: "\f04a"; } + +.fa-caret-right::before { + content: "\f0da"; } + +.fa-comments::before { + content: "\f086"; } + +.fa-paste::before { + content: "\f0ea"; } + +.fa-file-clipboard::before { + content: "\f0ea"; } + +.fa-code-pull-request::before { + content: "\e13c"; } + +.fa-clipboard-list::before { + content: "\f46d"; } + +.fa-truck-ramp-box::before { + content: "\f4de"; } + +.fa-truck-loading::before { + content: "\f4de"; } + +.fa-user-check::before { + content: "\f4fc"; } + +.fa-vial-virus::before { + content: "\e597"; } + +.fa-sheet-plastic::before { + content: "\e571"; } + +.fa-blog::before { + content: "\f781"; } + +.fa-user-ninja::before { + content: "\f504"; } + +.fa-person-arrow-up-from-line::before { + content: "\e539"; } + +.fa-scroll-torah::before { + content: "\f6a0"; } + +.fa-torah::before { + content: "\f6a0"; } + +.fa-broom-ball::before { + content: "\f458"; } + +.fa-quidditch::before { + content: "\f458"; } + +.fa-quidditch-broom-ball::before { + content: "\f458"; } + +.fa-toggle-off::before { + content: "\f204"; } + +.fa-box-archive::before { + content: "\f187"; } + +.fa-archive::before { + content: "\f187"; } + +.fa-person-drowning::before { + content: "\e545"; } + +.fa-arrow-down-9-1::before { + content: "\f886"; } + +.fa-sort-numeric-desc::before { + content: "\f886"; } + +.fa-sort-numeric-down-alt::before { + content: "\f886"; } + +.fa-face-grin-tongue-squint::before { + content: "\f58a"; } + +.fa-grin-tongue-squint::before { + content: "\f58a"; } + +.fa-spray-can::before { + content: "\f5bd"; } + +.fa-truck-monster::before { + content: "\f63b"; } + +.fa-w::before { + content: "\57"; } + +.fa-earth-africa::before { + content: "\f57c"; } + +.fa-globe-africa::before { + content: "\f57c"; } + +.fa-rainbow::before { + content: "\f75b"; } + +.fa-circle-notch::before { + content: "\f1ce"; } + +.fa-tablet-screen-button::before { + content: "\f3fa"; } + +.fa-tablet-alt::before { + content: "\f3fa"; } + +.fa-paw::before { + content: "\f1b0"; } + +.fa-cloud::before { + content: "\f0c2"; } + +.fa-trowel-bricks::before { + content: "\e58a"; } + +.fa-face-flushed::before { + content: "\f579"; } + +.fa-flushed::before { + content: "\f579"; } + +.fa-hospital-user::before { + content: "\f80d"; } + +.fa-tent-arrow-left-right::before { + content: "\e57f"; } + +.fa-gavel::before { + content: "\f0e3"; } + +.fa-legal::before { + content: "\f0e3"; } + +.fa-binoculars::before { + content: "\f1e5"; } + +.fa-microphone-slash::before { + content: "\f131"; } + +.fa-box-tissue::before { + content: "\e05b"; } + +.fa-motorcycle::before { + content: "\f21c"; } + +.fa-bell-concierge::before { + content: "\f562"; } + +.fa-concierge-bell::before { + content: "\f562"; } + +.fa-pen-ruler::before { + content: "\f5ae"; } + +.fa-pencil-ruler::before { + content: "\f5ae"; } + +.fa-people-arrows::before { + content: "\e068"; } + +.fa-people-arrows-left-right::before { + content: "\e068"; } + +.fa-mars-and-venus-burst::before { + content: "\e523"; } + +.fa-square-caret-right::before { + content: "\f152"; } + +.fa-caret-square-right::before { + content: "\f152"; } + +.fa-scissors::before { + content: "\f0c4"; } + +.fa-cut::before { + content: "\f0c4"; } + +.fa-sun-plant-wilt::before { + content: "\e57a"; } + +.fa-toilets-portable::before { + content: "\e584"; } + +.fa-hockey-puck::before { + content: "\f453"; } + +.fa-table::before { + content: "\f0ce"; } + +.fa-magnifying-glass-arrow-right::before { + content: "\e521"; } + +.fa-tachograph-digital::before { + content: "\f566"; } + +.fa-digital-tachograph::before { + content: "\f566"; } + +.fa-users-slash::before { + content: "\e073"; } + +.fa-clover::before { + content: "\e139"; } + +.fa-reply::before { + content: "\f3e5"; } + +.fa-mail-reply::before { + content: "\f3e5"; } + +.fa-star-and-crescent::before { + content: "\f699"; } + +.fa-house-fire::before { + content: "\e50c"; } + +.fa-square-minus::before { + content: "\f146"; } + +.fa-minus-square::before { + content: "\f146"; } + +.fa-helicopter::before { + content: "\f533"; } + +.fa-compass::before { + content: "\f14e"; } + +.fa-square-caret-down::before { + content: "\f150"; } + +.fa-caret-square-down::before { + content: "\f150"; } + +.fa-file-circle-question::before { + content: "\e4ef"; } + +.fa-laptop-code::before { + content: "\f5fc"; } + +.fa-swatchbook::before { + content: "\f5c3"; } + +.fa-prescription-bottle::before { + content: "\f485"; } + +.fa-bars::before { + content: "\f0c9"; } + +.fa-navicon::before { + content: "\f0c9"; } + +.fa-people-group::before { + content: "\e533"; } + +.fa-hourglass-end::before { + content: "\f253"; } + +.fa-hourglass-3::before { + content: "\f253"; } + +.fa-heart-crack::before { + content: "\f7a9"; } + +.fa-heart-broken::before { + content: "\f7a9"; } + +.fa-square-up-right::before { + content: "\f360"; } + +.fa-external-link-square-alt::before { + content: "\f360"; } + +.fa-face-kiss-beam::before { + content: "\f597"; } + +.fa-kiss-beam::before { + content: "\f597"; } + +.fa-film::before { + content: "\f008"; } + +.fa-ruler-horizontal::before { + content: "\f547"; } + +.fa-people-robbery::before { + content: "\e536"; } + +.fa-lightbulb::before { + content: "\f0eb"; } + +.fa-caret-left::before { + content: "\f0d9"; } + +.fa-circle-exclamation::before { + content: "\f06a"; } + +.fa-exclamation-circle::before { + content: "\f06a"; } + +.fa-school-circle-xmark::before { + content: "\e56d"; } + +.fa-arrow-right-from-bracket::before { + content: "\f08b"; } + +.fa-sign-out::before { + content: "\f08b"; } + +.fa-circle-chevron-down::before { + content: "\f13a"; } + +.fa-chevron-circle-down::before { + content: "\f13a"; } + +.fa-unlock-keyhole::before { + content: "\f13e"; } + +.fa-unlock-alt::before { + content: "\f13e"; } + +.fa-cloud-showers-heavy::before { + content: "\f740"; } + +.fa-headphones-simple::before { + content: "\f58f"; } + +.fa-headphones-alt::before { + content: "\f58f"; } + +.fa-sitemap::before { + content: "\f0e8"; } + +.fa-circle-dollar-to-slot::before { + content: "\f4b9"; } + +.fa-donate::before { + content: "\f4b9"; } + +.fa-memory::before { + content: "\f538"; } + +.fa-road-spikes::before { + content: "\e568"; } + +.fa-fire-burner::before { + content: "\e4f1"; } + +.fa-flag::before { + content: "\f024"; } + +.fa-hanukiah::before { + content: "\f6e6"; } + +.fa-feather::before { + content: "\f52d"; } + +.fa-volume-low::before { + content: "\f027"; } + +.fa-volume-down::before { + content: "\f027"; } + +.fa-comment-slash::before { + content: "\f4b3"; } + +.fa-cloud-sun-rain::before { + content: "\f743"; } + +.fa-compress::before { + content: "\f066"; } + +.fa-wheat-awn::before { + content: "\e2cd"; } + +.fa-wheat-alt::before { + content: "\e2cd"; } + +.fa-ankh::before { + content: "\f644"; } + +.fa-hands-holding-child::before { + content: "\e4fa"; } + +.fa-asterisk::before { + content: "\2a"; } + +.fa-square-check::before { + content: "\f14a"; } + +.fa-check-square::before { + content: "\f14a"; } + +.fa-peseta-sign::before { + content: "\e221"; } + +.fa-heading::before { + content: "\f1dc"; } + +.fa-header::before { + content: "\f1dc"; } + +.fa-ghost::before { + content: "\f6e2"; } + +.fa-list::before { + content: "\f03a"; } + +.fa-list-squares::before { + content: "\f03a"; } + +.fa-square-phone-flip::before { + content: "\f87b"; } + +.fa-phone-square-alt::before { + content: "\f87b"; } + +.fa-cart-plus::before { + content: "\f217"; } + +.fa-gamepad::before { + content: "\f11b"; } + +.fa-circle-dot::before { + content: "\f192"; } + +.fa-dot-circle::before { + content: "\f192"; } + +.fa-face-dizzy::before { + content: "\f567"; } + +.fa-dizzy::before { + content: "\f567"; } + +.fa-egg::before { + content: "\f7fb"; } + +.fa-house-medical-circle-xmark::before { + content: "\e513"; } + +.fa-campground::before { + content: "\f6bb"; } + +.fa-folder-plus::before { + content: "\f65e"; } + +.fa-futbol::before { + content: "\f1e3"; } + +.fa-futbol-ball::before { + content: "\f1e3"; } + +.fa-soccer-ball::before { + content: "\f1e3"; } + +.fa-paintbrush::before { + content: "\f1fc"; } + +.fa-paint-brush::before { + content: "\f1fc"; } + +.fa-lock::before { + content: "\f023"; } + +.fa-gas-pump::before { + content: "\f52f"; } + +.fa-hot-tub-person::before { + content: "\f593"; } + +.fa-hot-tub::before { + content: "\f593"; } + +.fa-map-location::before { + content: "\f59f"; } + +.fa-map-marked::before { + content: "\f59f"; } + +.fa-house-flood-water::before { + content: "\e50e"; } + +.fa-tree::before { + content: 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content: "\e072"; } + +.fa-apple-whole::before { + content: "\f5d1"; } + +.fa-apple-alt::before { + content: "\f5d1"; } + +.fa-kitchen-set::before { + content: "\e51a"; } + +.fa-r::before { + content: "\52"; } + +.fa-temperature-quarter::before { + content: "\f2ca"; } + +.fa-temperature-1::before { + content: "\f2ca"; } + +.fa-thermometer-1::before { + content: "\f2ca"; } + +.fa-thermometer-quarter::before { + content: "\f2ca"; } + +.fa-cube::before { + content: "\f1b2"; } + +.fa-bitcoin-sign::before { + content: "\e0b4"; } + +.fa-shield-dog::before { + content: "\e573"; } + +.fa-solar-panel::before { + content: "\f5ba"; } + +.fa-lock-open::before { + content: "\f3c1"; } + +.fa-elevator::before { + content: "\e16d"; } + +.fa-money-bill-transfer::before { + content: "\e528"; } + +.fa-money-bill-trend-up::before { + content: "\e529"; } + +.fa-house-flood-water-circle-arrow-right::before { + content: "\e50f"; } + +.fa-square-poll-horizontal::before { + content: "\f682"; } + 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{ + content: "\f46c"; } + +.fa-file-audio::before { + content: "\f1c7"; } + +.fa-burger::before { + content: "\f805"; } + +.fa-hamburger::before { + content: "\f805"; } + +.fa-wrench::before { + content: "\f0ad"; } + +.fa-bugs::before { + content: "\e4d0"; } + +.fa-rupee-sign::before { + content: "\f156"; } + +.fa-rupee::before { + content: "\f156"; } + +.fa-file-image::before { + content: "\f1c5"; } + +.fa-circle-question::before { + content: "\f059"; } + +.fa-question-circle::before { + content: "\f059"; } + +.fa-plane-departure::before { + content: "\f5b0"; } + +.fa-handshake-slash::before { + content: "\e060"; } + +.fa-book-bookmark::before { + content: "\e0bb"; } + +.fa-code-branch::before { + content: "\f126"; } + +.fa-hat-cowboy::before { + content: "\f8c0"; } + +.fa-bridge::before { + content: "\e4c8"; } + +.fa-phone-flip::before { + content: "\f879"; } + +.fa-phone-alt::before { + content: "\f879"; } + +.fa-truck-front::before { + content: "\e2b7"; } + +.fa-cat::before { + 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"\e3b2"; } + +.fa-golf-ball-tee::before { + content: "\f450"; } + +.fa-golf-ball::before { + content: "\f450"; } + +.fa-circle-chevron-left::before { + content: "\f137"; } + +.fa-chevron-circle-left::before { + content: "\f137"; } + +.fa-house-chimney-window::before { + content: "\e00d"; } + +.fa-pen-nib::before { + content: "\f5ad"; } + +.fa-tent-arrow-turn-left::before { + content: "\e580"; } + +.fa-tents::before { + content: "\e582"; } + +.fa-wand-magic::before { + content: "\f0d0"; } + +.fa-magic::before { + content: "\f0d0"; } + +.fa-dog::before { + content: "\f6d3"; } + +.fa-carrot::before { + content: "\f787"; } + +.fa-moon::before { + content: "\f186"; } + +.fa-wine-glass-empty::before { + content: "\f5ce"; } + +.fa-wine-glass-alt::before { + content: "\f5ce"; } + +.fa-cheese::before { + content: "\f7ef"; } + +.fa-yin-yang::before { + content: "\f6ad"; } + +.fa-music::before { + content: "\f001"; } + +.fa-code-commit::before { + content: "\f386"; } + 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content: "\e596"; } + +.fa-person-arrow-down-to-line::before { + content: "\e538"; } + +.fa-voicemail::before { + content: "\f897"; } + +.fa-fan::before { + content: "\f863"; } + +.fa-person-walking-luggage::before { + content: "\e554"; } + +.fa-up-down::before { + content: "\f338"; } + +.fa-arrows-alt-v::before { + content: "\f338"; } + +.fa-cloud-moon-rain::before { + content: "\f73c"; } + +.fa-calendar::before { + content: "\f133"; } + +.fa-trailer::before { + content: "\e041"; } + +.fa-bahai::before { + content: "\f666"; } + +.fa-haykal::before { + content: "\f666"; } + +.fa-sd-card::before { + content: "\f7c2"; } + +.fa-dragon::before { + content: "\f6d5"; } + +.fa-shoe-prints::before { + content: "\f54b"; } + +.fa-circle-plus::before { + content: "\f055"; } + +.fa-plus-circle::before { + content: "\f055"; } + +.fa-face-grin-tongue-wink::before { + content: "\f58b"; } + +.fa-grin-tongue-wink::before { + content: "\f58b"; } + +.fa-hand-holding::before { + content: "\f4bd"; } + +.fa-plug-circle-exclamation::before { + content: "\e55d"; } + +.fa-link-slash::before { + content: "\f127"; } + +.fa-chain-broken::before { + content: "\f127"; } + +.fa-chain-slash::before { + content: "\f127"; } + +.fa-unlink::before { + content: "\f127"; } + +.fa-clone::before { + content: "\f24d"; } + +.fa-person-walking-arrow-loop-left::before { + content: "\e551"; } + +.fa-arrow-up-z-a::before { + content: "\f882"; } + +.fa-sort-alpha-up-alt::before { + content: "\f882"; } + +.fa-fire-flame-curved::before { + content: "\f7e4"; } + +.fa-fire-alt::before { + content: "\f7e4"; } + +.fa-tornado::before { + content: "\f76f"; } + +.fa-file-circle-plus::before { + content: "\e494"; } + +.fa-book-quran::before { + content: "\f687"; } + +.fa-quran::before { + content: "\f687"; } + +.fa-anchor::before { + content: "\f13d"; } + +.fa-border-all::before { + content: "\f84c"; } + +.fa-face-angry::before { + content: "\f556"; } + +.fa-angry::before { + content: "\f556"; } + 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{ + content: "\f00c"; } + +.fa-battery-three-quarters::before { + content: "\f241"; } + +.fa-battery-4::before { + content: "\f241"; } + +.fa-house-circle-check::before { + content: "\e509"; } + +.fa-angle-left::before { + content: "\f104"; } + +.fa-diagram-successor::before { + content: "\e47a"; } + +.fa-truck-arrow-right::before { + content: "\e58b"; } + +.fa-arrows-split-up-and-left::before { + content: "\e4bc"; } + +.fa-hand-fist::before { + content: "\f6de"; } + +.fa-fist-raised::before { + content: "\f6de"; } + +.fa-cloud-moon::before { + content: "\f6c3"; } + +.fa-briefcase::before { + content: "\f0b1"; } + +.fa-person-falling::before { + content: "\e546"; } + +.fa-image-portrait::before { + content: "\f3e0"; } + +.fa-portrait::before { + content: "\f3e0"; } + +.fa-user-tag::before { + content: "\f507"; } + +.fa-rug::before { + content: "\e569"; } + +.fa-earth-europe::before { + content: "\f7a2"; } + +.fa-globe-europe::before { + content: "\f7a2"; } + +.fa-cart-flatbed-suitcase::before { + content: "\f59d"; } + +.fa-luggage-cart::before { + content: "\f59d"; } + +.fa-rectangle-xmark::before { + content: "\f410"; } + +.fa-rectangle-times::before { + content: "\f410"; } + +.fa-times-rectangle::before { + content: "\f410"; } + +.fa-window-close::before { + content: "\f410"; } + +.fa-baht-sign::before { + content: "\e0ac"; } + +.fa-book-open::before { + content: "\f518"; } + +.fa-book-journal-whills::before { + content: "\f66a"; } + +.fa-journal-whills::before { + content: "\f66a"; } + +.fa-handcuffs::before { + content: "\e4f8"; } + +.fa-triangle-exclamation::before { + content: "\f071"; } + +.fa-exclamation-triangle::before { + content: "\f071"; } + +.fa-warning::before { + content: "\f071"; } + +.fa-database::before { + content: "\f1c0"; } + +.fa-share::before { + content: "\f064"; } + +.fa-mail-forward::before { + content: "\f064"; } + +.fa-bottle-droplet::before { + content: "\e4c4"; } + +.fa-mask-face::before { + content: "\e1d7"; } + +.fa-hill-rockslide::before { + content: "\e508"; } + +.fa-right-left::before { + content: "\f362"; } + +.fa-exchange-alt::before { + content: "\f362"; } + +.fa-paper-plane::before { + content: "\f1d8"; } + +.fa-road-circle-exclamation::before { + content: "\e565"; } + +.fa-dungeon::before { + content: "\f6d9"; } + +.fa-align-right::before { + content: "\f038"; } + +.fa-money-bill-1-wave::before { + content: "\f53b"; } + +.fa-money-bill-wave-alt::before { + content: "\f53b"; } + +.fa-life-ring::before { + content: "\f1cd"; } + +.fa-hands::before { + content: "\f2a7"; } + +.fa-sign-language::before { + content: "\f2a7"; } + +.fa-signing::before { + content: "\f2a7"; } + +.fa-calendar-day::before { + content: "\f783"; } + +.fa-water-ladder::before { + content: "\f5c5"; } + +.fa-ladder-water::before { + content: "\f5c5"; } + +.fa-swimming-pool::before { + content: "\f5c5"; } + +.fa-arrows-up-down::before { + content: "\f07d"; } + +.fa-arrows-v::before { + content: "\f07d"; } + +.fa-face-grimace::before { + content: "\f57f"; } + +.fa-grimace::before { + content: "\f57f"; } + +.fa-wheelchair-move::before { + content: "\e2ce"; } + +.fa-wheelchair-alt::before { + content: "\e2ce"; } + +.fa-turn-down::before { + content: "\f3be"; } + +.fa-level-down-alt::before { + content: "\f3be"; } + +.fa-person-walking-arrow-right::before { + content: "\e552"; } + +.fa-square-envelope::before { + content: "\f199"; } + +.fa-envelope-square::before { + content: "\f199"; } + +.fa-dice::before { + content: "\f522"; } + +.fa-bowling-ball::before { + content: "\f436"; } + +.fa-brain::before { + content: "\f5dc"; } + +.fa-bandage::before { + content: "\f462"; } + +.fa-band-aid::before { + content: "\f462"; } + +.fa-calendar-minus::before { + content: "\f272"; } + +.fa-circle-xmark::before { + content: "\f057"; } + +.fa-times-circle::before { + content: "\f057"; } + +.fa-xmark-circle::before { + content: "\f057"; } + +.fa-gifts::before { + content: "\f79c"; } + +.fa-hotel::before { + content: "\f594"; } + +.fa-earth-asia::before { + content: "\f57e"; } + +.fa-globe-asia::before { + content: "\f57e"; } + +.fa-id-card-clip::before { + content: "\f47f"; } + +.fa-id-card-alt::before { + content: "\f47f"; } + +.fa-magnifying-glass-plus::before { + content: "\f00e"; } + +.fa-search-plus::before { + content: "\f00e"; } + +.fa-thumbs-up::before { + content: "\f164"; } + +.fa-user-clock::before { + content: "\f4fd"; } + +.fa-hand-dots::before { + content: "\f461"; } + +.fa-allergies::before { + content: "\f461"; } + +.fa-file-invoice::before { + content: "\f570"; } + +.fa-window-minimize::before { + content: "\f2d1"; } + +.fa-mug-saucer::before { + content: "\f0f4"; } + +.fa-coffee::before { + content: "\f0f4"; } + +.fa-brush::before { + content: "\f55d"; } + +.fa-mask::before { + content: "\f6fa"; } + +.fa-magnifying-glass-minus::before { + content: "\f010"; } + +.fa-search-minus::before { + content: "\f010"; } + +.fa-ruler-vertical::before { + content: "\f548"; } + +.fa-user-large::before { + content: "\f406"; } + +.fa-user-alt::before { + content: "\f406"; } + +.fa-train-tram::before { + content: "\e5b4"; } + +.fa-user-nurse::before { + content: "\f82f"; } + +.fa-syringe::before { + content: "\f48e"; } + +.fa-cloud-sun::before { + content: "\f6c4"; } + +.fa-stopwatch-20::before { + content: "\e06f"; } + +.fa-square-full::before { + content: "\f45c"; } + +.fa-magnet::before { + content: "\f076"; } + +.fa-jar::before { + content: "\e516"; } + +.fa-note-sticky::before { + content: "\f249"; } + +.fa-sticky-note::before { + content: "\f249"; } + +.fa-bug-slash::before { + content: "\e490"; } + +.fa-arrow-up-from-water-pump::before { + content: "\e4b6"; } + +.fa-bone::before { + content: "\f5d7"; } + +.fa-user-injured::before { + content: "\f728"; } + +.fa-face-sad-tear::before { + content: "\f5b4"; } + +.fa-sad-tear::before { + content: "\f5b4"; } + +.fa-plane::before { + content: "\f072"; } + +.fa-tent-arrows-down::before { + content: "\e581"; } + +.fa-exclamation::before { + content: "\21"; } + +.fa-arrows-spin::before { + content: "\e4bb"; } + +.fa-print::before { + content: "\f02f"; } + +.fa-turkish-lira-sign::before { + content: "\e2bb"; } + +.fa-try::before { + content: "\e2bb"; } + +.fa-turkish-lira::before { + content: "\e2bb"; } + +.fa-dollar-sign::before { + content: "\24"; } + +.fa-dollar::before { + content: "\24"; } + +.fa-usd::before { + content: "\24"; } + +.fa-x::before { + content: "\58"; } + +.fa-magnifying-glass-dollar::before { + content: "\f688"; } + +.fa-search-dollar::before { + content: "\f688"; } + +.fa-users-gear::before { + content: "\f509"; } + +.fa-users-cog::before { + content: "\f509"; } + +.fa-person-military-pointing::before { + content: "\e54a"; } + +.fa-building-columns::before { + content: "\f19c"; } + +.fa-bank::before { + content: "\f19c"; } + +.fa-institution::before { + content: "\f19c"; } + +.fa-museum::before { + content: "\f19c"; } + +.fa-university::before { + content: "\f19c"; } + +.fa-umbrella::before { + content: "\f0e9"; } + +.fa-trowel::before { + content: "\e589"; } + +.fa-d::before { + content: "\44"; } + +.fa-stapler::before { + content: "\e5af"; } + +.fa-masks-theater::before { + content: "\f630"; } + +.fa-theater-masks::before { + content: "\f630"; } + +.fa-kip-sign::before { + content: "\e1c4"; } + +.fa-hand-point-left::before { + content: "\f0a5"; } + +.fa-handshake-simple::before { + content: "\f4c6"; } + +.fa-handshake-alt::before { + content: "\f4c6"; } + +.fa-jet-fighter::before { + content: "\f0fb"; } + +.fa-fighter-jet::before { + content: "\f0fb"; } + +.fa-square-share-nodes::before { + content: "\f1e1"; } + +.fa-share-alt-square::before { + content: "\f1e1"; } + +.fa-barcode::before { + content: "\f02a"; } + +.fa-plus-minus::before { + content: "\e43c"; } + +.fa-video::before { + content: "\f03d"; } + +.fa-video-camera::before { + content: "\f03d"; } + +.fa-graduation-cap::before { + content: "\f19d"; } + +.fa-mortar-board::before { + content: "\f19d"; } + +.fa-hand-holding-medical::before { + content: "\e05c"; } + +.fa-person-circle-check::before { + content: "\e53e"; } + +.fa-turn-up::before { + content: "\f3bf"; } + +.fa-level-up-alt::before { + content: "\f3bf"; } + +.sr-only, +.fa-sr-only { + position: absolute; + width: 1px; + height: 1px; + padding: 0; + margin: -1px; + overflow: hidden; + clip: rect(0, 0, 0, 0); + white-space: nowrap; + border-width: 0; } + +.sr-only-focusable:not(:focus), +.fa-sr-only-focusable:not(:focus) { + position: absolute; + width: 1px; + height: 1px; + padding: 0; + margin: -1px; + overflow: hidden; + clip: rect(0, 0, 0, 0); + white-space: nowrap; + border-width: 0; } +:root, :host { + --fa-style-family-brands: 'Font Awesome 6 Brands'; + --fa-font-brands: normal 400 1em/1 'Font Awesome 6 Brands'; } + +@font-face { + font-family: 'Font Awesome 6 Brands'; + font-style: normal; + font-weight: 400; + font-display: block; + src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); } + +.fab, +.fa-brands { + font-weight: 400; } + +.fa-monero:before { + content: "\f3d0"; } + +.fa-hooli:before { + content: "\f427"; } + +.fa-yelp:before { + content: "\f1e9"; } + +.fa-cc-visa:before { + content: "\f1f0"; } + +.fa-lastfm:before { + content: "\f202"; } + +.fa-shopware:before { + content: "\f5b5"; } + +.fa-creative-commons-nc:before { + content: "\f4e8"; } + +.fa-aws:before { + content: "\f375"; } + +.fa-redhat:before { + content: "\f7bc"; } + +.fa-yoast:before { + content: "\f2b1"; } + +.fa-cloudflare:before { + content: "\e07d"; } + +.fa-ups:before { + content: "\f7e0"; } + +.fa-pixiv:before { + content: "\e640"; } + +.fa-wpexplorer:before { + content: "\f2de"; } + +.fa-dyalog:before { + content: "\f399"; } + +.fa-bity:before { + content: "\f37a"; } + +.fa-stackpath:before { + content: "\f842"; } + +.fa-buysellads:before { + content: "\f20d"; } + +.fa-first-order:before { + content: "\f2b0"; } + +.fa-modx:before 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Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-comments-o:before { + content: "\f086"; } + +.fa.fa-flash:before { + content: "\f0e7"; } + +.fa.fa-clipboard:before { + content: "\f0ea"; } + +.fa.fa-lightbulb-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-lightbulb-o:before { + content: "\f0eb"; } + +.fa.fa-exchange:before { + content: "\f362"; } + +.fa.fa-cloud-download:before { + content: "\f0ed"; } + +.fa.fa-cloud-upload:before { + content: "\f0ee"; } + +.fa.fa-bell-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-bell-o:before { + content: "\f0f3"; } + +.fa.fa-cutlery:before { + content: "\f2e7"; } + +.fa.fa-file-text-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-text-o:before { + content: "\f15c"; } + +.fa.fa-building-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-building-o:before { + content: "\f1ad"; } + +.fa.fa-hospital-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-hospital-o:before { + content: "\f0f8"; } + +.fa.fa-tablet:before { + content: "\f3fa"; } + +.fa.fa-mobile:before { + content: "\f3cd"; } + +.fa.fa-mobile-phone:before { + content: "\f3cd"; } + +.fa.fa-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-circle-o:before { + content: "\f111"; } + +.fa.fa-mail-reply:before { + content: "\f3e5"; } + +.fa.fa-github-alt { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-folder-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-folder-o:before { + content: "\f07b"; } + +.fa.fa-folder-open-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-folder-open-o:before { + content: "\f07c"; } + +.fa.fa-smile-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-smile-o:before { + content: "\f118"; } + +.fa.fa-frown-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-frown-o:before { + content: "\f119"; } + +.fa.fa-meh-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-meh-o:before { + content: "\f11a"; } + +.fa.fa-keyboard-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-keyboard-o:before { + content: "\f11c"; } + +.fa.fa-flag-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-flag-o:before { + content: "\f024"; } + +.fa.fa-mail-reply-all:before { + content: "\f122"; } + +.fa.fa-star-half-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-star-half-o:before { + content: "\f5c0"; } + +.fa.fa-star-half-empty { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-star-half-empty:before { + content: "\f5c0"; } + +.fa.fa-star-half-full { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-star-half-full:before { + content: "\f5c0"; } + +.fa.fa-code-fork:before { + content: "\f126"; } + +.fa.fa-chain-broken:before { + content: "\f127"; } + +.fa.fa-unlink:before { + content: "\f127"; } + +.fa.fa-calendar-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-calendar-o:before { + content: "\f133"; } + +.fa.fa-maxcdn { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-html5 { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-css3 { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-unlock-alt:before { + content: "\f09c"; } + +.fa.fa-minus-square-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-minus-square-o:before { + content: "\f146"; } + +.fa.fa-level-up:before { + content: "\f3bf"; } + +.fa.fa-level-down:before { + content: "\f3be"; } + +.fa.fa-pencil-square:before { + content: "\f14b"; } + +.fa.fa-external-link-square:before { + content: "\f360"; } + +.fa.fa-compass { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-down { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-down:before { + content: "\f150"; } + +.fa.fa-toggle-down { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-down:before { + content: "\f150"; } + +.fa.fa-caret-square-o-up { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-up:before { + content: "\f151"; } + +.fa.fa-toggle-up { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-up:before { + content: "\f151"; } + +.fa.fa-caret-square-o-right { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-right:before { + content: "\f152"; } + +.fa.fa-toggle-right { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-right:before { + content: "\f152"; } + +.fa.fa-eur:before { + content: "\f153"; } + +.fa.fa-euro:before { + content: "\f153"; } + +.fa.fa-gbp:before { + content: "\f154"; } + +.fa.fa-usd:before { + content: "\24"; } + +.fa.fa-dollar:before { + content: "\24"; } + +.fa.fa-inr:before { + content: "\e1bc"; } + +.fa.fa-rupee:before { + content: "\e1bc"; } + +.fa.fa-jpy:before { + content: "\f157"; } + +.fa.fa-cny:before { + content: "\f157"; } + +.fa.fa-rmb:before { + content: "\f157"; } + +.fa.fa-yen:before { + content: "\f157"; } + +.fa.fa-rub:before { + content: "\f158"; } + +.fa.fa-ruble:before { + content: "\f158"; } + +.fa.fa-rouble:before { + content: "\f158"; } + +.fa.fa-krw:before { + content: "\f159"; } + +.fa.fa-won:before { + content: "\f159"; } + +.fa.fa-btc { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitcoin { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitcoin:before { + content: "\f15a"; } + +.fa.fa-file-text:before { + content: "\f15c"; } + +.fa.fa-sort-alpha-asc:before { + content: "\f15d"; } + +.fa.fa-sort-alpha-desc:before { + content: "\f881"; } + +.fa.fa-sort-amount-asc:before { + content: "\f884"; } + +.fa.fa-sort-amount-desc:before { + content: "\f160"; } + +.fa.fa-sort-numeric-asc:before { + content: "\f162"; } + +.fa.fa-sort-numeric-desc:before { + content: "\f886"; } + +.fa.fa-youtube-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-youtube-square:before { + content: "\f431"; } + +.fa.fa-youtube { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-xing { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-xing-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-xing-square:before { + content: "\f169"; } + +.fa.fa-youtube-play { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-youtube-play:before { + content: "\f167"; } + +.fa.fa-dropbox { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-stack-overflow { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-instagram { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-flickr { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-adn { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitbucket { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitbucket-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitbucket-square:before { + content: "\f171"; } + +.fa.fa-tumblr { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-tumblr-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-tumblr-square:before { + content: "\f174"; } + +.fa.fa-long-arrow-down:before { + content: "\f309"; } + +.fa.fa-long-arrow-up:before { + content: "\f30c"; } + +.fa.fa-long-arrow-left:before { + content: "\f30a"; } + +.fa.fa-long-arrow-right:before { + content: "\f30b"; } + +.fa.fa-apple { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-windows { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-android { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-linux { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-dribbble { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-skype { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-foursquare { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-trello { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-gratipay { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-gittip { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-gittip:before { + content: "\f184"; } + +.fa.fa-sun-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-sun-o:before { + content: "\f185"; } + +.fa.fa-moon-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-moon-o:before { + content: "\f186"; } + +.fa.fa-vk { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-weibo { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-renren { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pagelines { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-stack-exchange { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-arrow-circle-o-right { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-arrow-circle-o-right:before { + content: "\f35a"; } + +.fa.fa-arrow-circle-o-left { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-arrow-circle-o-left:before { + content: "\f359"; } + +.fa.fa-caret-square-o-left { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-left:before { + content: "\f191"; } + +.fa.fa-toggle-left { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-left:before { + content: "\f191"; } + +.fa.fa-dot-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-dot-circle-o:before { + content: "\f192"; } + +.fa.fa-vimeo-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-vimeo-square:before { + content: "\f194"; } + +.fa.fa-try:before { + content: "\e2bb"; } + +.fa.fa-turkish-lira:before { + content: "\e2bb"; } + +.fa.fa-plus-square-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-plus-square-o:before { + content: "\f0fe"; } + +.fa.fa-slack { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wordpress { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-openid { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-institution:before { + content: "\f19c"; } + +.fa.fa-bank:before { + content: "\f19c"; } + +.fa.fa-mortar-board:before { + content: "\f19d"; } + +.fa.fa-yahoo { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-reddit { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-reddit-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-reddit-square:before { + content: "\f1a2"; } + +.fa.fa-stumbleupon-circle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-stumbleupon { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-delicious { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-digg { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pied-piper-pp { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pied-piper-alt { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-drupal { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-joomla { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-behance { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-behance-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-behance-square:before { + content: "\f1b5"; } + +.fa.fa-steam { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-steam-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-steam-square:before { + content: "\f1b7"; } + +.fa.fa-automobile:before { + content: "\f1b9"; } + +.fa.fa-cab:before { + content: "\f1ba"; } + +.fa.fa-spotify { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-deviantart { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-soundcloud { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-file-pdf-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-pdf-o:before { + content: "\f1c1"; } + +.fa.fa-file-word-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-word-o:before { + content: "\f1c2"; } + +.fa.fa-file-excel-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-excel-o:before { + content: "\f1c3"; } + +.fa.fa-file-powerpoint-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-powerpoint-o:before { + content: "\f1c4"; } + +.fa.fa-file-image-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-image-o:before { + content: "\f1c5"; } + +.fa.fa-file-photo-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-photo-o:before { + content: "\f1c5"; } + +.fa.fa-file-picture-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-picture-o:before { + content: "\f1c5"; } + +.fa.fa-file-archive-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-archive-o:before { + content: "\f1c6"; } + +.fa.fa-file-zip-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-zip-o:before { + content: "\f1c6"; } + +.fa.fa-file-audio-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-audio-o:before { + content: "\f1c7"; } + +.fa.fa-file-sound-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-sound-o:before { + content: "\f1c7"; } + +.fa.fa-file-video-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-video-o:before { + content: "\f1c8"; } + +.fa.fa-file-movie-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-movie-o:before { + content: "\f1c8"; } + +.fa.fa-file-code-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-code-o:before { + content: "\f1c9"; } + +.fa.fa-vine { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-codepen { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-jsfiddle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-life-bouy:before { + content: "\f1cd"; } + +.fa.fa-life-buoy:before { + content: "\f1cd"; } + +.fa.fa-life-saver:before { + content: "\f1cd"; } + +.fa.fa-support:before { + content: "\f1cd"; } + +.fa.fa-circle-o-notch:before { + content: "\f1ce"; } + +.fa.fa-rebel { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ra { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ra:before { + content: "\f1d0"; } + +.fa.fa-resistance { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-resistance:before { + content: "\f1d0"; } + +.fa.fa-empire { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ge { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ge:before { + content: "\f1d1"; } + +.fa.fa-git-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-git-square:before { + content: "\f1d2"; } + +.fa.fa-git { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-hacker-news { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-y-combinator-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-y-combinator-square:before { + content: "\f1d4"; } + +.fa.fa-yc-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-yc-square:before { + content: "\f1d4"; } + +.fa.fa-tencent-weibo { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-qq { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-weixin { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wechat { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wechat:before { + content: "\f1d7"; } + +.fa.fa-send:before { + content: "\f1d8"; } + +.fa.fa-paper-plane-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-paper-plane-o:before { + content: "\f1d8"; } + +.fa.fa-send-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-send-o:before { + content: "\f1d8"; } + +.fa.fa-circle-thin { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-circle-thin:before { + content: "\f111"; } + +.fa.fa-header:before { + content: "\f1dc"; } + +.fa.fa-futbol-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-futbol-o:before { + content: "\f1e3"; } + +.fa.fa-soccer-ball-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-soccer-ball-o:before { + content: "\f1e3"; } + +.fa.fa-slideshare { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-twitch { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-yelp { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-newspaper-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-newspaper-o:before { + content: "\f1ea"; } + +.fa.fa-paypal { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-wallet { + 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} + +.fa.fa-credit-card-alt:before { + content: "\f09d"; } + +.fa.fa-codiepie { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-modx { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-fort-awesome { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-usb { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-product-hunt { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-mixcloud { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-scribd { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pause-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-pause-circle-o:before { + content: "\f28b"; } + +.fa.fa-stop-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-stop-circle-o:before { + content: "\f28d"; } + +.fa.fa-bluetooth { + font-family: 'Font Awesome 6 Brands'; + font-weight: 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} + +.fa.fa-themeisle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-plus-official { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-plus-official:before { + content: "\f2b3"; } + +.fa.fa-google-plus-circle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-plus-circle:before { + content: "\f2b3"; } + +.fa.fa-font-awesome { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-fa { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-fa:before { + content: "\f2b4"; } + +.fa.fa-handshake-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-handshake-o:before { + content: "\f2b5"; } + +.fa.fa-envelope-open-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-envelope-open-o:before { + content: "\f2b6"; } + +.fa.fa-linode { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-address-book-o { + 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content: "\f2dc"; } + +.fa.fa-superpowers { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wpexplorer { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-meetup { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } diff --git a/docs/deps/font-awesome-6.5.2/css/v4-shims.min.css b/docs/deps/font-awesome-6.5.2/css/v4-shims.min.css new file mode 100644 index 0000000..09baf5f --- /dev/null +++ b/docs/deps/font-awesome-6.5.2/css/v4-shims.min.css @@ -0,0 +1,6 @@ +/*! + * Font Awesome Free 6.5.2 by @fontawesome - https://fontawesome.com + * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) + * Copyright 2024 Fonticons, Inc. + */ +.fa.fa-glass:before{content:"\f000"}.fa.fa-envelope-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-envelope-o:before{content:"\f0e0"}.fa.fa-star-o{font-family:"Font Awesome 6 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Hide your header until you need it + * Copyright (c) 2017 Nick Williams - http://wicky.nillia.ms/headroom.js + * License: MIT + */ + +!function(a){a&&(a.fn.headroom=function(b){return this.each(function(){var c=a(this),d=c.data("headroom"),e="object"==typeof b&&b;e=a.extend(!0,{},Headroom.options,e),d||(d=new Headroom(this,e),d.init(),c.data("headroom",d)),"string"==typeof b&&(d[b](),"destroy"===b&&c.removeData("headroom"))})},a("[data-headroom]").each(function(){var b=a(this);b.headroom(b.data())}))}(window.Zepto||window.jQuery); \ No newline at end of file diff --git a/docs/deps/jquery-3.6.0/jquery-3.6.0.js b/docs/deps/jquery-3.6.0/jquery-3.6.0.js new file mode 100644 index 0000000..fc6c299 --- /dev/null +++ b/docs/deps/jquery-3.6.0/jquery-3.6.0.js @@ -0,0 +1,10881 @@ +/*! + * jQuery JavaScript Library v3.6.0 + * https://jquery.com/ + * + * Includes Sizzle.js + * https://sizzlejs.com/ + * + * Copyright OpenJS Foundation and other contributors + * Released under the MIT license + * https://jquery.org/license + * + * Date: 2021-03-02T17:08Z + */ +( function( global, factory ) { + + "use strict"; + + if ( typeof module === "object" && typeof module.exports === "object" ) { + + // For CommonJS and CommonJS-like environments where a proper `window` + // is present, execute the factory and get jQuery. + // For environments that do not have a `window` with a `document` + // (such as Node.js), expose a factory as module.exports. + // This accentuates the need for the creation of a real `window`. + // e.g. var jQuery = require("jquery")(window); + // See ticket #14549 for more info. + module.exports = global.document ? + factory( global, true ) : + function( w ) { + if ( !w.document ) { + throw new Error( "jQuery requires a window with a document" ); + } + return factory( w ); + }; + } else { + factory( global ); + } + +// Pass this if window is not defined yet +} )( typeof window !== "undefined" ? window : this, function( window, noGlobal ) { + +// Edge <= 12 - 13+, Firefox <=18 - 45+, IE 10 - 11, Safari 5.1 - 9+, iOS 6 - 9.1 +// throw exceptions when non-strict code (e.g., ASP.NET 4.5) accesses strict mode +// arguments.callee.caller (trac-13335). 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(gh-4756) + return typeof obj === "function" && typeof obj.nodeType !== "number" && + typeof obj.item !== "function"; + }; + + +var isWindow = function isWindow( obj ) { + return obj != null && obj === obj.window; + }; + + +var document = window.document; + + + + var preservedScriptAttributes = { + type: true, + src: true, + nonce: true, + noModule: true + }; + + function DOMEval( code, node, doc ) { + doc = doc || document; + + var i, val, + script = doc.createElement( "script" ); + + script.text = code; + if ( node ) { + for ( i in preservedScriptAttributes ) { + + // Support: Firefox 64+, Edge 18+ + // Some browsers don't support the "nonce" property on scripts. + // On the other hand, just using `getAttribute` is not enough as + // the `nonce` attribute is reset to an empty string whenever it + // becomes browsing-context connected. + // See https://github.com/whatwg/html/issues/2369 + // See https://html.spec.whatwg.org/#nonce-attributes + // The `node.getAttribute` check was added for the sake of + // `jQuery.globalEval` so that it can fake a nonce-containing node + // via an object. + val = node[ i ] || node.getAttribute && node.getAttribute( i ); + if ( val ) { + script.setAttribute( i, val ); + } + } + } + doc.head.appendChild( script ).parentNode.removeChild( script ); + } + + +function toType( obj ) { + if ( obj == null ) { + return obj + ""; + } + + // Support: Android <=2.3 only (functionish RegExp) + return typeof obj === "object" || typeof obj === "function" ? + class2type[ toString.call( obj ) ] || "object" : + typeof obj; +} +/* global Symbol */ +// Defining this global in .eslintrc.json would create a danger of using the global +// unguarded in another place, it seems safer to define global only for this module + + + +var + version = "3.6.0", + + // Define a local copy of jQuery + jQuery = function( selector, context ) { + + // The jQuery object is actually just the init constructor 'enhanced' + // Need init if jQuery is called (just allow error to be thrown if not included) + return new jQuery.fn.init( selector, context ); + }; + +jQuery.fn = jQuery.prototype = { + + // The current version of jQuery being used + jquery: version, + + constructor: jQuery, + + // The default length of a jQuery object is 0 + length: 0, + + toArray: function() { + return slice.call( this ); + }, + + // Get the Nth element in the matched element set OR + // Get the whole matched element set as a clean array + get: function( num ) { + + // Return all the elements in a clean array + if ( num == null ) { + return slice.call( this ); + } + + // Return just the one element from the set + return num < 0 ? this[ num + this.length ] : this[ num ]; + }, + + // Take an array of elements and push it onto the stack + // (returning the new matched element set) + pushStack: function( elems ) { + + // Build a new jQuery matched element set + var ret = jQuery.merge( this.constructor(), elems ); + + // Add the old object onto the stack (as a reference) + ret.prevObject = this; + + // Return the newly-formed element set + return ret; + }, + + // Execute a callback for every element in the matched set. + each: function( callback ) { + return jQuery.each( this, callback ); + }, + + map: function( callback ) { + return this.pushStack( jQuery.map( this, function( elem, i ) { + return callback.call( elem, i, elem ); + } ) ); + }, + + slice: function() { + return this.pushStack( slice.apply( this, arguments ) ); + }, + + first: function() { + return this.eq( 0 ); + }, + + last: function() { + return this.eq( -1 ); + }, + + even: function() { + return this.pushStack( jQuery.grep( this, function( _elem, i ) { + return ( i + 1 ) % 2; + } ) ); + }, + + odd: function() { + return this.pushStack( jQuery.grep( this, function( _elem, i ) { + return i % 2; + } ) ); + }, + + eq: function( i ) { + var len = this.length, + j = +i + ( i < 0 ? len : 0 ); + return this.pushStack( j >= 0 && j < len ? [ this[ j ] ] : [] ); + }, + + end: function() { + return this.prevObject || this.constructor(); + }, + + // For internal use only. + // Behaves like an Array's method, not like a jQuery method. + push: push, + sort: arr.sort, + splice: arr.splice +}; + +jQuery.extend = jQuery.fn.extend = function() { + var options, name, src, copy, copyIsArray, clone, + target = arguments[ 0 ] || {}, + i = 1, + length = arguments.length, + deep = false; + + // Handle a deep copy situation + if ( typeof target === "boolean" ) { + deep = target; + + // Skip the boolean and the target + target = arguments[ i ] || {}; + i++; + } + + // Handle case when target is a string or something (possible in deep copy) + if ( typeof target !== "object" && !isFunction( target ) ) { + target = {}; + } + + // Extend jQuery itself if only one argument is passed + if ( i === length ) { + target = this; + i--; + } + + for ( ; i < length; i++ ) { + + // Only deal with non-null/undefined values + if ( ( options = arguments[ i ] ) != null ) { + + // Extend the base object + for ( name in options ) { + copy = options[ name ]; + + // Prevent Object.prototype pollution + // Prevent never-ending loop + if ( name === "__proto__" || target === copy ) { + continue; + } + + // Recurse if we're merging plain objects or arrays + if ( deep && copy && ( jQuery.isPlainObject( copy ) || + ( copyIsArray = Array.isArray( copy ) ) ) ) { + src = target[ name ]; + + // Ensure proper type for the source value + if ( copyIsArray && !Array.isArray( src ) ) { + clone = []; + } else if ( !copyIsArray && !jQuery.isPlainObject( src ) ) { + clone = {}; + } else { + clone = src; + } + copyIsArray = false; + + // Never move original objects, clone them + target[ name ] = jQuery.extend( deep, clone, copy ); + + // Don't bring in undefined values + } else if ( copy !== undefined ) { + target[ name ] = copy; + } + } + } + } + + // Return the modified object + return target; +}; + +jQuery.extend( { + + // Unique for each copy of jQuery on the page + expando: "jQuery" + ( version + Math.random() ).replace( /\D/g, "" ), + + // Assume jQuery is ready without the ready module + isReady: true, + + error: function( msg ) { + throw new Error( msg ); + }, + + noop: function() {}, + + isPlainObject: function( obj ) { + var proto, Ctor; + + // Detect obvious negatives + // Use toString instead of jQuery.type to catch host objects + if ( !obj || toString.call( obj ) !== "[object Object]" ) { + return false; + } + + proto = getProto( obj ); + + // Objects with no prototype (e.g., `Object.create( null )`) are plain + if ( !proto ) { + return true; + } + + // Objects with prototype are plain iff they were constructed by a global Object function + Ctor = hasOwn.call( proto, "constructor" ) && proto.constructor; + return typeof Ctor === "function" && fnToString.call( Ctor ) === ObjectFunctionString; + }, + + isEmptyObject: function( obj ) { + var name; + + for ( name in obj ) { + return false; + } + return true; + }, + + // Evaluates a script in a provided context; falls back to the global one + // if not specified. + globalEval: function( code, options, doc ) { + DOMEval( code, { nonce: options && options.nonce }, doc ); + }, + + each: function( obj, callback ) { + var length, i = 0; + + if ( isArrayLike( obj ) ) { + length = obj.length; + for ( ; i < length; i++ ) { + if ( callback.call( obj[ i ], i, obj[ i ] ) === false ) { + break; + } + } + } else { + for ( i in obj ) { + if ( callback.call( obj[ i ], i, obj[ i ] ) === false ) { + break; + } + } + } + + return obj; + }, + + // results is for internal usage only + makeArray: function( arr, results ) { + var ret = results || []; + + if ( arr != null ) { + if ( isArrayLike( Object( arr ) ) ) { + jQuery.merge( ret, + typeof arr === "string" ? + [ arr ] : arr + ); + } else { + push.call( ret, arr ); + } + } + + return ret; + }, + + inArray: function( elem, arr, i ) { + return arr == null ? -1 : indexOf.call( arr, elem, i ); + }, + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + merge: function( first, second ) { + var len = +second.length, + j = 0, + i = first.length; + + for ( ; j < len; j++ ) { + first[ i++ ] = second[ j ]; + } + + first.length = i; + + return first; + }, + + grep: function( elems, callback, invert ) { + var callbackInverse, + matches = [], + i = 0, + length = elems.length, + callbackExpect = !invert; + + // Go through the array, only saving the items + // that pass the validator function + for ( ; i < length; i++ ) { + callbackInverse = !callback( elems[ i ], i ); + if ( callbackInverse !== callbackExpect ) { + matches.push( elems[ i ] ); + } + } + + return matches; + }, + + // arg is for internal usage only + map: function( elems, callback, arg ) { + var length, value, + i = 0, + ret = []; + + // Go through the array, translating each of the items to their new values + if ( isArrayLike( elems ) ) { + length = elems.length; + for ( ; i < length; i++ ) { + value = callback( elems[ i ], i, arg ); + + if ( value != null ) { + ret.push( value ); + } + } + + // Go through every key on the object, + } else { + for ( i in elems ) { + value = callback( elems[ i ], i, arg ); + + if ( value != null ) { + ret.push( value ); + } + } + } + + // Flatten any nested arrays + return flat( ret ); + }, + + // A global GUID counter for objects + guid: 1, + + // jQuery.support is not used in Core but other projects attach their + // properties to it so it needs to exist. + support: support +} ); + +if ( typeof Symbol === "function" ) { + jQuery.fn[ Symbol.iterator ] = arr[ Symbol.iterator ]; +} + +// Populate the class2type map +jQuery.each( "Boolean Number String Function Array Date RegExp Object Error Symbol".split( " " ), + function( _i, name ) { + class2type[ "[object " + name + "]" ] = name.toLowerCase(); + } ); + +function isArrayLike( obj ) { + + // Support: real iOS 8.2 only (not reproducible in simulator) + // `in` check used to prevent JIT error (gh-2145) + // hasOwn isn't used here due to false negatives + // regarding Nodelist length in IE + var length = !!obj && "length" in obj && obj.length, + type = toType( obj ); + + if ( isFunction( obj ) || isWindow( obj ) ) { + return false; + } + + return type === "array" || length === 0 || + typeof length === "number" && length > 0 && ( length - 1 ) in obj; +} +var Sizzle = +/*! + * Sizzle CSS Selector Engine v2.3.6 + * https://sizzlejs.com/ + * + * Copyright JS Foundation and other contributors + * Released under the MIT license + * https://js.foundation/ + * + * Date: 2021-02-16 + */ +( function( window ) { +var i, + support, + Expr, + getText, + isXML, + tokenize, + compile, + select, + outermostContext, + sortInput, + hasDuplicate, + + // Local document vars + setDocument, + document, + docElem, + documentIsHTML, + rbuggyQSA, + rbuggyMatches, + matches, + contains, + + // Instance-specific data + expando = "sizzle" + 1 * new Date(), + preferredDoc = window.document, + dirruns = 0, + done = 0, + classCache = createCache(), + tokenCache = createCache(), + compilerCache = createCache(), + nonnativeSelectorCache = createCache(), + sortOrder = function( a, b ) { + if ( a === b ) { + hasDuplicate = true; + } + return 0; + }, + + // Instance methods + hasOwn = ( {} ).hasOwnProperty, + arr = [], + pop = arr.pop, + pushNative = arr.push, + push = arr.push, + slice = arr.slice, + + // Use a stripped-down indexOf as it's faster than native + // https://jsperf.com/thor-indexof-vs-for/5 + indexOf = function( list, elem ) { + var i = 0, + len = list.length; + for ( ; i < len; i++ ) { + if ( list[ i ] === elem ) { + return i; + } + } + return -1; + }, + + booleans = "checked|selected|async|autofocus|autoplay|controls|defer|disabled|hidden|" + + "ismap|loop|multiple|open|readonly|required|scoped", + + // Regular expressions + + // http://www.w3.org/TR/css3-selectors/#whitespace + whitespace = "[\\x20\\t\\r\\n\\f]", + + // https://www.w3.org/TR/css-syntax-3/#ident-token-diagram + identifier = "(?:\\\\[\\da-fA-F]{1,6}" + whitespace + + "?|\\\\[^\\r\\n\\f]|[\\w-]|[^\0-\\x7f])+", + + // Attribute selectors: http://www.w3.org/TR/selectors/#attribute-selectors + attributes = "\\[" + whitespace + "*(" + identifier + ")(?:" + whitespace + + + // Operator (capture 2) + "*([*^$|!~]?=)" + whitespace + + + // "Attribute values must be CSS identifiers [capture 5] + // or strings [capture 3 or capture 4]" + "*(?:'((?:\\\\.|[^\\\\'])*)'|\"((?:\\\\.|[^\\\\\"])*)\"|(" + identifier + "))|)" + + whitespace + "*\\]", + + pseudos = ":(" + identifier + ")(?:\\((" + + + // To reduce the number of selectors needing tokenize in the preFilter, prefer arguments: + // 1. quoted (capture 3; capture 4 or capture 5) + "('((?:\\\\.|[^\\\\'])*)'|\"((?:\\\\.|[^\\\\\"])*)\")|" + + + // 2. simple (capture 6) + "((?:\\\\.|[^\\\\()[\\]]|" + attributes + ")*)|" + + + // 3. anything else (capture 2) + ".*" + + ")\\)|)", + + // Leading and non-escaped trailing whitespace, capturing some non-whitespace characters preceding the latter + rwhitespace = new RegExp( whitespace + "+", "g" ), + rtrim = new RegExp( "^" + whitespace + "+|((?:^|[^\\\\])(?:\\\\.)*)" + + whitespace + "+$", "g" ), + + rcomma = new RegExp( "^" + whitespace + "*," + whitespace + "*" ), + rcombinators = new RegExp( "^" + whitespace + "*([>+~]|" + whitespace + ")" + whitespace + + "*" ), + rdescend = new RegExp( whitespace + "|>" ), + + rpseudo = new RegExp( pseudos ), + ridentifier = new RegExp( "^" + identifier + "$" ), + + matchExpr = { + "ID": new RegExp( "^#(" + identifier + ")" ), + "CLASS": new RegExp( "^\\.(" + identifier + ")" ), + "TAG": new RegExp( "^(" + identifier + "|[*])" ), + "ATTR": new RegExp( "^" + attributes ), + "PSEUDO": new RegExp( "^" + pseudos ), + "CHILD": new RegExp( "^:(only|first|last|nth|nth-last)-(child|of-type)(?:\\(" + + whitespace + "*(even|odd|(([+-]|)(\\d*)n|)" + whitespace + "*(?:([+-]|)" + + whitespace + "*(\\d+)|))" + whitespace + "*\\)|)", "i" ), + "bool": new RegExp( "^(?:" + booleans + ")$", "i" ), + + // For use in libraries implementing .is() + // We use this for POS matching in `select` + "needsContext": new RegExp( "^" + whitespace + + "*[>+~]|:(even|odd|eq|gt|lt|nth|first|last)(?:\\(" + whitespace + + "*((?:-\\d)?\\d*)" + whitespace + "*\\)|)(?=[^-]|$)", "i" ) + }, + + rhtml = /HTML$/i, + rinputs = /^(?:input|select|textarea|button)$/i, + rheader = /^h\d$/i, + + rnative = /^[^{]+\{\s*\[native \w/, + + // Easily-parseable/retrievable ID or TAG or CLASS selectors + rquickExpr = /^(?:#([\w-]+)|(\w+)|\.([\w-]+))$/, + + rsibling = /[+~]/, + + // CSS escapes + // http://www.w3.org/TR/CSS21/syndata.html#escaped-characters + runescape = new RegExp( "\\\\[\\da-fA-F]{1,6}" + whitespace + "?|\\\\([^\\r\\n\\f])", "g" ), + funescape = function( escape, nonHex ) { + var high = "0x" + escape.slice( 1 ) - 0x10000; + + return nonHex ? + + // Strip the backslash prefix from a non-hex escape sequence + nonHex : + + // Replace a hexadecimal escape sequence with the encoded Unicode code point + // Support: IE <=11+ + // For values outside the Basic Multilingual Plane (BMP), manually construct a + // surrogate pair + high < 0 ? + String.fromCharCode( high + 0x10000 ) : + String.fromCharCode( high >> 10 | 0xD800, high & 0x3FF | 0xDC00 ); + }, + + // CSS string/identifier serialization + // https://drafts.csswg.org/cssom/#common-serializing-idioms + rcssescape = /([\0-\x1f\x7f]|^-?\d)|^-$|[^\0-\x1f\x7f-\uFFFF\w-]/g, + fcssescape = function( ch, asCodePoint ) { + if ( asCodePoint ) { + + // U+0000 NULL becomes U+FFFD REPLACEMENT CHARACTER + if ( ch === "\0" ) { + return "\uFFFD"; + } + + // Control characters and (dependent upon position) numbers get escaped as code points + return ch.slice( 0, -1 ) + "\\" + + ch.charCodeAt( ch.length - 1 ).toString( 16 ) + " "; + } + + // Other potentially-special ASCII characters get backslash-escaped + return "\\" + ch; + }, + + // Used for iframes + // See setDocument() + // Removing the function wrapper causes a "Permission Denied" + // error in IE + unloadHandler = function() { + setDocument(); + }, + + inDisabledFieldset = addCombinator( + function( elem ) { + return elem.disabled === true && elem.nodeName.toLowerCase() === "fieldset"; + }, + { dir: "parentNode", next: "legend" } + ); + +// Optimize for push.apply( _, NodeList ) +try { + push.apply( + ( arr = slice.call( preferredDoc.childNodes ) ), + preferredDoc.childNodes + ); + + // Support: Android<4.0 + // Detect silently failing push.apply + // eslint-disable-next-line no-unused-expressions + arr[ preferredDoc.childNodes.length ].nodeType; +} catch ( e ) { + push = { apply: arr.length ? + + // Leverage slice if possible + function( target, els ) { + pushNative.apply( target, slice.call( els ) ); + } : + + // Support: IE<9 + // Otherwise append directly + function( target, els ) { + var j = target.length, + i = 0; + + // Can't trust NodeList.length + while ( ( target[ j++ ] = els[ i++ ] ) ) {} + target.length = j - 1; + } + }; +} + +function Sizzle( selector, context, results, seed ) { + var m, i, elem, nid, match, groups, newSelector, + newContext = context && context.ownerDocument, + + // nodeType defaults to 9, since context defaults to document + nodeType = context ? context.nodeType : 9; + + results = results || []; + + // Return early from calls with invalid selector or context + if ( typeof selector !== "string" || !selector || + nodeType !== 1 && nodeType !== 9 && nodeType !== 11 ) { + + return results; + } + + // Try to shortcut find operations (as opposed to filters) in HTML documents + if ( !seed ) { + setDocument( context ); + context = context || document; + + if ( documentIsHTML ) { + + // If the selector is sufficiently simple, try using a "get*By*" DOM method + // (excepting DocumentFragment context, where the methods don't exist) + if ( nodeType !== 11 && ( match = rquickExpr.exec( selector ) ) ) { + + // ID selector + if ( ( m = match[ 1 ] ) ) { + + // Document context + if ( nodeType === 9 ) { + if ( ( elem = context.getElementById( m ) ) ) { + + // Support: IE, Opera, Webkit + // TODO: identify versions + // getElementById can match elements by name instead of ID + if ( elem.id === m ) { + results.push( elem ); + return results; + } + } else { + return results; + } + + // Element context + } else { + + // Support: IE, Opera, Webkit + // TODO: identify versions + // getElementById can match elements by name instead of ID + if ( newContext && ( elem = newContext.getElementById( m ) ) && + contains( context, elem ) && + elem.id === m ) { + + results.push( elem ); + return results; + } + } + + // Type selector + } else if ( match[ 2 ] ) { + push.apply( results, context.getElementsByTagName( selector ) ); + return results; + + // Class selector + } else if ( ( m = match[ 3 ] ) && support.getElementsByClassName && + context.getElementsByClassName ) { + + push.apply( results, context.getElementsByClassName( m ) ); + return results; + } + } + + // Take advantage of querySelectorAll + if ( support.qsa && + !nonnativeSelectorCache[ selector + " " ] && + ( !rbuggyQSA || !rbuggyQSA.test( selector ) ) && + + // Support: IE 8 only + // Exclude object elements + ( nodeType !== 1 || context.nodeName.toLowerCase() !== "object" ) ) { + + newSelector = selector; + newContext = context; + + // qSA considers elements outside a scoping root when evaluating child or + // descendant combinators, which is not what we want. + // In such cases, we work around the behavior by prefixing every selector in the + // list with an ID selector referencing the scope context. + // The technique has to be used as well when a leading combinator is used + // as such selectors are not recognized by querySelectorAll. + // Thanks to Andrew Dupont for this technique. + if ( nodeType === 1 && + ( rdescend.test( selector ) || rcombinators.test( selector ) ) ) { + + // Expand context for sibling selectors + newContext = rsibling.test( selector ) && testContext( context.parentNode ) || + context; + + // We can use :scope instead of the ID hack if the browser + // supports it & if we're not changing the context. + if ( newContext !== context || !support.scope ) { + + // Capture the context ID, setting it first if necessary + if ( ( nid = context.getAttribute( "id" ) ) ) { + nid = nid.replace( rcssescape, fcssescape ); + } else { + context.setAttribute( "id", ( nid = expando ) ); + } + } + + // Prefix every selector in the list + groups = tokenize( selector ); + i = groups.length; + while ( i-- ) { + groups[ i ] = ( nid ? "#" + nid : ":scope" ) + " " + + toSelector( groups[ i ] ); + } + newSelector = groups.join( "," ); + } + + try { + push.apply( results, + newContext.querySelectorAll( newSelector ) + ); + return results; + } catch ( qsaError ) { + nonnativeSelectorCache( selector, true ); + } finally { + if ( nid === expando ) { + context.removeAttribute( "id" ); + } + } + } + } + } + + // All others + return select( selector.replace( rtrim, "$1" ), context, results, seed ); +} + +/** + * Create key-value caches of limited size + * @returns {function(string, object)} Returns the Object data after storing it on itself with + * property name the (space-suffixed) string and (if the cache is larger than Expr.cacheLength) + * deleting the oldest entry + */ +function createCache() { + var keys = []; + + function cache( key, value ) { + + // Use (key + " ") to avoid collision with native prototype properties (see Issue #157) + if ( keys.push( key + " " ) > Expr.cacheLength ) { + + // Only keep the most recent entries + delete cache[ keys.shift() ]; + } + return ( cache[ key + " " ] = value ); + } + return cache; +} + +/** + * Mark a function for special use by Sizzle + * @param {Function} fn The function to mark + */ +function markFunction( fn ) { + fn[ expando ] = true; + return fn; +} + +/** + * Support testing using an element + * @param {Function} fn Passed the created element and returns a boolean result + */ +function assert( fn ) { + var el = document.createElement( "fieldset" ); + + try { + return !!fn( el ); + } catch ( e ) { + return false; + } finally { + + // Remove from its parent by default + if ( el.parentNode ) { + el.parentNode.removeChild( el ); + } + + // release memory in IE + el = null; + } +} + +/** + * Adds the same handler for all of the specified attrs + * @param {String} attrs Pipe-separated list of attributes + * @param {Function} handler The method that will be applied + */ +function addHandle( attrs, handler ) { + var arr = attrs.split( "|" ), + i = arr.length; + + while ( i-- ) { + Expr.attrHandle[ arr[ i ] ] = handler; + } +} + +/** + * Checks document order of two siblings + * @param {Element} a + * @param {Element} b + * @returns {Number} Returns less than 0 if a precedes b, greater than 0 if a follows b + */ +function siblingCheck( a, b ) { + var cur = b && a, + diff = cur && a.nodeType === 1 && b.nodeType === 1 && + a.sourceIndex - b.sourceIndex; + + // Use IE sourceIndex if available on both nodes + if ( diff ) { + return diff; + } + + // Check if b follows a + if ( cur ) { + while ( ( cur = cur.nextSibling ) ) { + if ( cur === b ) { + return -1; + } + } + } + + return a ? 1 : -1; +} + +/** + * Returns a function to use in pseudos for input types + * @param {String} type + */ +function createInputPseudo( type ) { + return function( elem ) { + var name = elem.nodeName.toLowerCase(); + return name === "input" && elem.type === type; + }; +} + +/** + * Returns a function to use in pseudos for buttons + * @param {String} type + */ +function createButtonPseudo( type ) { + return function( elem ) { + var name = elem.nodeName.toLowerCase(); + return ( name === "input" || name === "button" ) && elem.type === type; + }; +} + +/** + * Returns a function to use in pseudos for :enabled/:disabled + * @param {Boolean} disabled true for :disabled; false for :enabled + */ +function createDisabledPseudo( disabled ) { + + // Known :disabled false positives: fieldset[disabled] > legend:nth-of-type(n+2) :can-disable + return function( elem ) { + + // Only certain elements can match :enabled or :disabled + // https://html.spec.whatwg.org/multipage/scripting.html#selector-enabled + // https://html.spec.whatwg.org/multipage/scripting.html#selector-disabled + if ( "form" in elem ) { + + // Check for inherited disabledness on relevant non-disabled elements: + // * listed form-associated elements in a disabled fieldset + // https://html.spec.whatwg.org/multipage/forms.html#category-listed + // https://html.spec.whatwg.org/multipage/forms.html#concept-fe-disabled + // * option elements in a disabled optgroup + // https://html.spec.whatwg.org/multipage/forms.html#concept-option-disabled + // All such elements have a "form" property. + if ( elem.parentNode && elem.disabled === false ) { + + // Option elements defer to a parent optgroup if present + if ( "label" in elem ) { + if ( "label" in elem.parentNode ) { + return elem.parentNode.disabled === disabled; + } else { + return elem.disabled === disabled; + } + } + + // Support: IE 6 - 11 + // Use the isDisabled shortcut property to check for disabled fieldset ancestors + return elem.isDisabled === disabled || + + // Where there is no isDisabled, check manually + /* jshint -W018 */ + elem.isDisabled !== !disabled && + inDisabledFieldset( elem ) === disabled; + } + + return elem.disabled === disabled; + + // Try to winnow out elements that can't be disabled before trusting the disabled property. + // Some victims get caught in our net (label, legend, menu, track), but it shouldn't + // even exist on them, let alone have a boolean value. + } else if ( "label" in elem ) { + return elem.disabled === disabled; + } + + // Remaining elements are neither :enabled nor :disabled + return false; + }; +} + +/** + * Returns a function to use in pseudos for positionals + * @param {Function} fn + */ +function createPositionalPseudo( fn ) { + return markFunction( function( argument ) { + argument = +argument; + return markFunction( function( seed, matches ) { + var j, + matchIndexes = fn( [], seed.length, argument ), + i = matchIndexes.length; + + // Match elements found at the specified indexes + while ( i-- ) { + if ( seed[ ( j = matchIndexes[ i ] ) ] ) { + seed[ j ] = !( matches[ j ] = seed[ j ] ); + } + } + } ); + } ); +} + +/** + * Checks a node for validity as a Sizzle context + * @param {Element|Object=} context + * @returns {Element|Object|Boolean} The input node if acceptable, otherwise a falsy value + */ +function testContext( context ) { + return context && typeof context.getElementsByTagName !== "undefined" && context; +} + +// Expose support vars for convenience +support = Sizzle.support = {}; + +/** + * Detects XML nodes + * @param {Element|Object} elem An element or a document + * @returns {Boolean} True iff elem is a non-HTML XML node + */ +isXML = Sizzle.isXML = function( elem ) { + var namespace = elem && elem.namespaceURI, + docElem = elem && ( elem.ownerDocument || elem ).documentElement; + + // Support: IE <=8 + // Assume HTML when documentElement doesn't yet exist, such as inside loading iframes + // https://bugs.jquery.com/ticket/4833 + return !rhtml.test( namespace || docElem && docElem.nodeName || "HTML" ); +}; + +/** + * Sets document-related variables once based on the current document + * @param {Element|Object} [doc] An element or document object to use to set the document + * @returns {Object} Returns the current document + */ +setDocument = Sizzle.setDocument = function( node ) { + var hasCompare, subWindow, + doc = node ? node.ownerDocument || node : preferredDoc; + + // Return early if doc is invalid or already selected + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( doc == document || doc.nodeType !== 9 || !doc.documentElement ) { + return document; + } + + // Update global variables + document = doc; + docElem = document.documentElement; + documentIsHTML = !isXML( document ); + + // Support: IE 9 - 11+, Edge 12 - 18+ + // Accessing iframe documents after unload throws "permission denied" errors (jQuery #13936) + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( preferredDoc != document && + ( subWindow = document.defaultView ) && subWindow.top !== subWindow ) { + + // Support: IE 11, Edge + if ( subWindow.addEventListener ) { + subWindow.addEventListener( "unload", unloadHandler, false ); + + // Support: IE 9 - 10 only + } else if ( subWindow.attachEvent ) { + subWindow.attachEvent( "onunload", unloadHandler ); + } + } + + // Support: IE 8 - 11+, Edge 12 - 18+, Chrome <=16 - 25 only, Firefox <=3.6 - 31 only, + // Safari 4 - 5 only, Opera <=11.6 - 12.x only + // IE/Edge & older browsers don't support the :scope pseudo-class. + // Support: Safari 6.0 only + // Safari 6.0 supports :scope but it's an alias of :root there. + support.scope = assert( function( el ) { + docElem.appendChild( el ).appendChild( document.createElement( "div" ) ); + return typeof el.querySelectorAll !== "undefined" && + !el.querySelectorAll( ":scope fieldset div" ).length; + } ); + + /* Attributes + ---------------------------------------------------------------------- */ + + // Support: IE<8 + // Verify that getAttribute really returns attributes and not properties + // (excepting IE8 booleans) + support.attributes = assert( function( el ) { + el.className = "i"; + return !el.getAttribute( "className" ); + } ); + + /* getElement(s)By* + ---------------------------------------------------------------------- */ + + // Check if getElementsByTagName("*") returns only elements + support.getElementsByTagName = assert( function( el ) { + el.appendChild( document.createComment( "" ) ); + return !el.getElementsByTagName( "*" ).length; + } ); + + // Support: IE<9 + support.getElementsByClassName = rnative.test( document.getElementsByClassName ); + + // Support: IE<10 + // Check if getElementById returns elements by name + // The broken getElementById methods don't pick up programmatically-set names, + // so use a roundabout getElementsByName test + support.getById = assert( function( el ) { + docElem.appendChild( el ).id = expando; + return !document.getElementsByName || !document.getElementsByName( expando ).length; + } ); + + // ID filter and find + if ( support.getById ) { + Expr.filter[ "ID" ] = function( id ) { + var attrId = id.replace( runescape, funescape ); + return function( elem ) { + return elem.getAttribute( "id" ) === attrId; + }; + }; + Expr.find[ "ID" ] = function( id, context ) { + if ( typeof context.getElementById !== "undefined" && documentIsHTML ) { + var elem = context.getElementById( id ); + return elem ? [ elem ] : []; + } + }; + } else { + Expr.filter[ "ID" ] = function( id ) { + var attrId = id.replace( runescape, funescape ); + return function( elem ) { + var node = typeof elem.getAttributeNode !== "undefined" && + elem.getAttributeNode( "id" ); + return node && node.value === attrId; + }; + }; + + // Support: IE 6 - 7 only + // getElementById is not reliable as a find shortcut + Expr.find[ "ID" ] = function( id, context ) { + if ( typeof context.getElementById !== "undefined" && documentIsHTML ) { + var node, i, elems, + elem = context.getElementById( id ); + + if ( elem ) { + + // Verify the id attribute + node = elem.getAttributeNode( "id" ); + if ( node && node.value === id ) { + return [ elem ]; + } + + // Fall back on getElementsByName + elems = context.getElementsByName( id ); + i = 0; + while ( ( elem = elems[ i++ ] ) ) { + node = elem.getAttributeNode( "id" ); + if ( node && node.value === id ) { + return [ elem ]; + } + } + } + + return []; + } + }; + } + + // Tag + Expr.find[ "TAG" ] = support.getElementsByTagName ? + function( tag, context ) { + if ( typeof context.getElementsByTagName !== "undefined" ) { + return context.getElementsByTagName( tag ); + + // DocumentFragment nodes don't have gEBTN + } else if ( support.qsa ) { + return context.querySelectorAll( tag ); + } + } : + + function( tag, context ) { + var elem, + tmp = [], + i = 0, + + // By happy coincidence, a (broken) gEBTN appears on DocumentFragment nodes too + results = context.getElementsByTagName( tag ); + + // Filter out possible comments + if ( tag === "*" ) { + while ( ( elem = results[ i++ ] ) ) { + if ( elem.nodeType === 1 ) { + tmp.push( elem ); + } + } + + return tmp; + } + return results; + }; + + // Class + Expr.find[ "CLASS" ] = support.getElementsByClassName && function( className, context ) { + if ( typeof context.getElementsByClassName !== "undefined" && documentIsHTML ) { + return context.getElementsByClassName( className ); + } + }; + + /* QSA/matchesSelector + ---------------------------------------------------------------------- */ + + // QSA and matchesSelector support + + // matchesSelector(:active) reports false when true (IE9/Opera 11.5) + rbuggyMatches = []; + + // qSa(:focus) reports false when true (Chrome 21) + // We allow this because of a bug in IE8/9 that throws an error + // whenever `document.activeElement` is accessed on an iframe + // So, we allow :focus to pass through QSA all the time to avoid the IE error + // See https://bugs.jquery.com/ticket/13378 + rbuggyQSA = []; + + if ( ( support.qsa = rnative.test( document.querySelectorAll ) ) ) { + + // Build QSA regex + // Regex strategy adopted from Diego Perini + assert( function( el ) { + + var input; + + // Select is set to empty string on purpose + // This is to test IE's treatment of not explicitly + // setting a boolean content attribute, + // since its presence should be enough + // https://bugs.jquery.com/ticket/12359 + docElem.appendChild( el ).innerHTML = "" + + ""; + + // Support: IE8, Opera 11-12.16 + // Nothing should be selected when empty strings follow ^= or $= or *= + // The test attribute must be unknown in Opera but "safe" for WinRT + // https://msdn.microsoft.com/en-us/library/ie/hh465388.aspx#attribute_section + if ( el.querySelectorAll( "[msallowcapture^='']" ).length ) { + rbuggyQSA.push( "[*^$]=" + whitespace + "*(?:''|\"\")" ); + } + + // Support: IE8 + // Boolean attributes and "value" are not treated correctly + if ( !el.querySelectorAll( "[selected]" ).length ) { + rbuggyQSA.push( "\\[" + whitespace + "*(?:value|" + booleans + ")" ); + } + + // Support: Chrome<29, Android<4.4, Safari<7.0+, iOS<7.0+, PhantomJS<1.9.8+ + if ( !el.querySelectorAll( "[id~=" + expando + "-]" ).length ) { + rbuggyQSA.push( "~=" ); + } + + // Support: IE 11+, Edge 15 - 18+ + // IE 11/Edge don't find elements on a `[name='']` query in some cases. + // Adding a temporary attribute to the document before the selection works + // around the issue. + // Interestingly, IE 10 & older don't seem to have the issue. + input = document.createElement( "input" ); + input.setAttribute( "name", "" ); + el.appendChild( input ); + if ( !el.querySelectorAll( "[name='']" ).length ) { + rbuggyQSA.push( "\\[" + whitespace + "*name" + whitespace + "*=" + + whitespace + "*(?:''|\"\")" ); + } + + // Webkit/Opera - :checked should return selected option elements + // http://www.w3.org/TR/2011/REC-css3-selectors-20110929/#checked + // IE8 throws error here and will not see later tests + if ( !el.querySelectorAll( ":checked" ).length ) { + rbuggyQSA.push( ":checked" ); + } + + // Support: Safari 8+, iOS 8+ + // https://bugs.webkit.org/show_bug.cgi?id=136851 + // In-page `selector#id sibling-combinator selector` fails + if ( !el.querySelectorAll( "a#" + expando + "+*" ).length ) { + rbuggyQSA.push( ".#.+[+~]" ); + } + + // Support: Firefox <=3.6 - 5 only + // Old Firefox doesn't throw on a badly-escaped identifier. + el.querySelectorAll( "\\\f" ); + rbuggyQSA.push( "[\\r\\n\\f]" ); + } ); + + assert( function( el ) { + el.innerHTML = "" + + ""; + + // Support: Windows 8 Native Apps + // The type and name attributes are restricted during .innerHTML assignment + var input = document.createElement( "input" ); + input.setAttribute( "type", "hidden" ); + el.appendChild( input ).setAttribute( "name", "D" ); + + // Support: IE8 + // Enforce case-sensitivity of name attribute + if ( el.querySelectorAll( "[name=d]" ).length ) { + rbuggyQSA.push( "name" + whitespace + "*[*^$|!~]?=" ); + } + + // FF 3.5 - :enabled/:disabled and hidden elements (hidden elements are still enabled) + // IE8 throws error here and will not see later tests + if ( el.querySelectorAll( ":enabled" ).length !== 2 ) { + rbuggyQSA.push( ":enabled", ":disabled" ); + } + + // Support: IE9-11+ + // IE's :disabled selector does not pick up the children of disabled fieldsets + docElem.appendChild( el ).disabled = true; + if ( el.querySelectorAll( ":disabled" ).length !== 2 ) { + rbuggyQSA.push( ":enabled", ":disabled" ); + } + + // Support: Opera 10 - 11 only + // Opera 10-11 does not throw on post-comma invalid pseudos + el.querySelectorAll( "*,:x" ); + rbuggyQSA.push( ",.*:" ); + } ); + } + + if ( ( support.matchesSelector = rnative.test( ( matches = docElem.matches || + docElem.webkitMatchesSelector || + docElem.mozMatchesSelector || + docElem.oMatchesSelector || + docElem.msMatchesSelector ) ) ) ) { + + assert( function( el ) { + + // Check to see if it's possible to do matchesSelector + // on a disconnected node (IE 9) + support.disconnectedMatch = matches.call( el, "*" ); + + // This should fail with an exception + // Gecko does not error, returns false instead + matches.call( el, "[s!='']:x" ); + rbuggyMatches.push( "!=", pseudos ); + } ); + } + + rbuggyQSA = rbuggyQSA.length && new RegExp( rbuggyQSA.join( "|" ) ); + rbuggyMatches = rbuggyMatches.length && new RegExp( rbuggyMatches.join( "|" ) ); + + /* Contains + ---------------------------------------------------------------------- */ + hasCompare = rnative.test( docElem.compareDocumentPosition ); + + // Element contains another + // Purposefully self-exclusive + // As in, an element does not contain itself + contains = hasCompare || rnative.test( docElem.contains ) ? + function( a, b ) { + var adown = a.nodeType === 9 ? a.documentElement : a, + bup = b && b.parentNode; + return a === bup || !!( bup && bup.nodeType === 1 && ( + adown.contains ? + adown.contains( bup ) : + a.compareDocumentPosition && a.compareDocumentPosition( bup ) & 16 + ) ); + } : + function( a, b ) { + if ( b ) { + while ( ( b = b.parentNode ) ) { + if ( b === a ) { + return true; + } + } + } + return false; + }; + + /* Sorting + ---------------------------------------------------------------------- */ + + // Document order sorting + sortOrder = hasCompare ? + function( a, b ) { + + // Flag for duplicate removal + if ( a === b ) { + hasDuplicate = true; + return 0; + } + + // Sort on method existence if only one input has compareDocumentPosition + var compare = !a.compareDocumentPosition - !b.compareDocumentPosition; + if ( compare ) { + return compare; + } + + // Calculate position if both inputs belong to the same document + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + compare = ( a.ownerDocument || a ) == ( b.ownerDocument || b ) ? + a.compareDocumentPosition( b ) : + + // Otherwise we know they are disconnected + 1; + + // Disconnected nodes + if ( compare & 1 || + ( !support.sortDetached && b.compareDocumentPosition( a ) === compare ) ) { + + // Choose the first element that is related to our preferred document + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( a == document || a.ownerDocument == preferredDoc && + contains( preferredDoc, a ) ) { + return -1; + } + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( b == document || b.ownerDocument == preferredDoc && + contains( preferredDoc, b ) ) { + return 1; + } + + // Maintain original order + return sortInput ? + ( indexOf( sortInput, a ) - indexOf( sortInput, b ) ) : + 0; + } + + return compare & 4 ? -1 : 1; + } : + function( a, b ) { + + // Exit early if the nodes are identical + if ( a === b ) { + hasDuplicate = true; + return 0; + } + + var cur, + i = 0, + aup = a.parentNode, + bup = b.parentNode, + ap = [ a ], + bp = [ b ]; + + // Parentless nodes are either documents or disconnected + if ( !aup || !bup ) { + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + /* eslint-disable eqeqeq */ + return a == document ? -1 : + b == document ? 1 : + /* eslint-enable eqeqeq */ + aup ? -1 : + bup ? 1 : + sortInput ? + ( indexOf( sortInput, a ) - indexOf( sortInput, b ) ) : + 0; + + // If the nodes are siblings, we can do a quick check + } else if ( aup === bup ) { + return siblingCheck( a, b ); + } + + // Otherwise we need full lists of their ancestors for comparison + cur = a; + while ( ( cur = cur.parentNode ) ) { + ap.unshift( cur ); + } + cur = b; + while ( ( cur = cur.parentNode ) ) { + bp.unshift( cur ); + } + + // Walk down the tree looking for a discrepancy + while ( ap[ i ] === bp[ i ] ) { + i++; + } + + return i ? + + // Do a sibling check if the nodes have a common ancestor + siblingCheck( ap[ i ], bp[ i ] ) : + + // Otherwise nodes in our document sort first + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + /* eslint-disable eqeqeq */ + ap[ i ] == preferredDoc ? -1 : + bp[ i ] == preferredDoc ? 1 : + /* eslint-enable eqeqeq */ + 0; + }; + + return document; +}; + +Sizzle.matches = function( expr, elements ) { + return Sizzle( expr, null, null, elements ); +}; + +Sizzle.matchesSelector = function( elem, expr ) { + setDocument( elem ); + + if ( support.matchesSelector && documentIsHTML && + !nonnativeSelectorCache[ expr + " " ] && + ( !rbuggyMatches || !rbuggyMatches.test( expr ) ) && + ( !rbuggyQSA || !rbuggyQSA.test( expr ) ) ) { + + try { + var ret = matches.call( elem, expr ); + + // IE 9's matchesSelector returns false on disconnected nodes + if ( ret || support.disconnectedMatch || + + // As well, disconnected nodes are said to be in a document + // fragment in IE 9 + elem.document && elem.document.nodeType !== 11 ) { + return ret; + } + } catch ( e ) { + nonnativeSelectorCache( expr, true ); + } + } + + return Sizzle( expr, document, null, [ elem ] ).length > 0; +}; + +Sizzle.contains = function( context, elem ) { + + // Set document vars if needed + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( ( context.ownerDocument || context ) != document ) { + setDocument( context ); + } + return contains( context, elem ); +}; + +Sizzle.attr = function( elem, name ) { + + // Set document vars if needed + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( ( elem.ownerDocument || elem ) != document ) { + setDocument( elem ); + } + + var fn = Expr.attrHandle[ name.toLowerCase() ], + + // Don't get fooled by Object.prototype properties (jQuery #13807) + val = fn && hasOwn.call( Expr.attrHandle, name.toLowerCase() ) ? + fn( elem, name, !documentIsHTML ) : + undefined; + + return val !== undefined ? + val : + support.attributes || !documentIsHTML ? + elem.getAttribute( name ) : + ( val = elem.getAttributeNode( name ) ) && val.specified ? + val.value : + null; +}; + +Sizzle.escape = function( sel ) { + return ( sel + "" ).replace( rcssescape, fcssescape ); +}; + +Sizzle.error = function( msg ) { + throw new Error( "Syntax error, unrecognized expression: " + msg ); +}; + +/** + * Document sorting and removing duplicates + * @param {ArrayLike} results + */ +Sizzle.uniqueSort = function( results ) { + var elem, + duplicates = [], + j = 0, + i = 0; + + // Unless we *know* we can detect duplicates, assume their presence + hasDuplicate = !support.detectDuplicates; + sortInput = !support.sortStable && results.slice( 0 ); + results.sort( sortOrder ); + + if ( hasDuplicate ) { + while ( ( elem = results[ i++ ] ) ) { + if ( elem === results[ i ] ) { + j = duplicates.push( i ); + } + } + while ( j-- ) { + results.splice( duplicates[ j ], 1 ); + } + } + + // Clear input after sorting to release objects + // See https://github.com/jquery/sizzle/pull/225 + sortInput = null; + + return results; +}; + +/** + * Utility function for retrieving the text value of an array of DOM nodes + * @param {Array|Element} elem + */ +getText = Sizzle.getText = function( elem ) { + var node, + ret = "", + i = 0, + nodeType = elem.nodeType; + + if ( !nodeType ) { + + // If no nodeType, this is expected to be an array + while ( ( node = elem[ i++ ] ) ) { + + // Do not traverse comment nodes + ret += getText( node ); + } + } else if ( nodeType === 1 || nodeType === 9 || nodeType === 11 ) { + + // Use textContent for elements + // innerText usage removed for consistency of new lines (jQuery #11153) + if ( typeof elem.textContent === "string" ) { + return elem.textContent; + } else { + + // Traverse its children + for ( elem = elem.firstChild; elem; elem = elem.nextSibling ) { + ret += getText( elem ); + } + } + } else if ( nodeType === 3 || nodeType === 4 ) { + return elem.nodeValue; + } + + // Do not include comment or processing instruction nodes + + return ret; +}; + +Expr = Sizzle.selectors = { + + // Can be adjusted by the user + cacheLength: 50, + + createPseudo: markFunction, + + match: matchExpr, + + attrHandle: {}, + + find: {}, + + relative: { + ">": { dir: "parentNode", first: true }, + " ": { dir: "parentNode" }, + "+": { dir: "previousSibling", first: true }, + "~": { dir: "previousSibling" } + }, + + preFilter: { + "ATTR": function( match ) { + match[ 1 ] = match[ 1 ].replace( runescape, funescape ); + + // Move the given value to match[3] whether quoted or unquoted + match[ 3 ] = ( match[ 3 ] || match[ 4 ] || + match[ 5 ] || "" ).replace( runescape, funescape ); + + if ( match[ 2 ] === "~=" ) { + match[ 3 ] = " " + match[ 3 ] + " "; + } + + return match.slice( 0, 4 ); + }, + + "CHILD": function( match ) { + + /* matches from matchExpr["CHILD"] + 1 type (only|nth|...) + 2 what (child|of-type) + 3 argument (even|odd|\d*|\d*n([+-]\d+)?|...) + 4 xn-component of xn+y argument ([+-]?\d*n|) + 5 sign of xn-component + 6 x of xn-component + 7 sign of y-component + 8 y of y-component + */ + match[ 1 ] = match[ 1 ].toLowerCase(); + + if ( match[ 1 ].slice( 0, 3 ) === "nth" ) { + + // nth-* requires argument + if ( !match[ 3 ] ) { + Sizzle.error( match[ 0 ] ); + } + + // numeric x and y parameters for Expr.filter.CHILD + // remember that false/true cast respectively to 0/1 + match[ 4 ] = +( match[ 4 ] ? + match[ 5 ] + ( match[ 6 ] || 1 ) : + 2 * ( match[ 3 ] === "even" || match[ 3 ] === "odd" ) ); + match[ 5 ] = +( ( match[ 7 ] + match[ 8 ] ) || match[ 3 ] === "odd" ); + + // other types prohibit arguments + } else if ( match[ 3 ] ) { + Sizzle.error( match[ 0 ] ); + } + + return match; + }, + + "PSEUDO": function( match ) { + var excess, + unquoted = !match[ 6 ] && match[ 2 ]; + + if ( matchExpr[ "CHILD" ].test( match[ 0 ] ) ) { + return null; + } + + // Accept quoted arguments as-is + if ( match[ 3 ] ) { + match[ 2 ] = match[ 4 ] || match[ 5 ] || ""; + + // Strip excess characters from unquoted arguments + } else if ( unquoted && rpseudo.test( unquoted ) && + + // Get excess from tokenize (recursively) + ( excess = tokenize( unquoted, true ) ) && + + // advance to the next closing parenthesis + ( excess = unquoted.indexOf( ")", unquoted.length - excess ) - unquoted.length ) ) { + + // excess is a negative index + match[ 0 ] = match[ 0 ].slice( 0, excess ); + match[ 2 ] = unquoted.slice( 0, excess ); + } + + // Return only captures needed by the pseudo filter method (type and argument) + return match.slice( 0, 3 ); + } + }, + + filter: { + + "TAG": function( nodeNameSelector ) { + var nodeName = nodeNameSelector.replace( runescape, funescape ).toLowerCase(); + return nodeNameSelector === "*" ? + function() { + return true; + } : + function( elem ) { + return elem.nodeName && elem.nodeName.toLowerCase() === nodeName; + }; + }, + + "CLASS": function( className ) { + var pattern = classCache[ className + " " ]; + + return pattern || + ( pattern = new RegExp( "(^|" + whitespace + + ")" + className + "(" + whitespace + "|$)" ) ) && classCache( + className, function( elem ) { + return pattern.test( + typeof elem.className === "string" && elem.className || + typeof elem.getAttribute !== "undefined" && + elem.getAttribute( "class" ) || + "" + ); + } ); + }, + + "ATTR": function( name, operator, check ) { + return function( elem ) { + var result = Sizzle.attr( elem, name ); + + if ( result == null ) { + return operator === "!="; + } + if ( !operator ) { + return true; + } + + result += ""; + + /* eslint-disable max-len */ + + return operator === "=" ? result === check : + operator === "!=" ? result !== check : + operator === "^=" ? check && result.indexOf( check ) === 0 : + operator === "*=" ? check && result.indexOf( check ) > -1 : + operator === "$=" ? check && result.slice( -check.length ) === check : + operator === "~=" ? ( " " + result.replace( rwhitespace, " " ) + " " ).indexOf( check ) > -1 : + operator === "|=" ? result === check || result.slice( 0, check.length + 1 ) === check + "-" : + false; + /* eslint-enable max-len */ + + }; + }, + + "CHILD": function( type, what, _argument, first, last ) { + var simple = type.slice( 0, 3 ) !== "nth", + forward = type.slice( -4 ) !== "last", + ofType = what === "of-type"; + + return first === 1 && last === 0 ? + + // Shortcut for :nth-*(n) + function( elem ) { + return !!elem.parentNode; + } : + + function( elem, _context, xml ) { + var cache, uniqueCache, outerCache, node, nodeIndex, start, + dir = simple !== forward ? "nextSibling" : "previousSibling", + parent = elem.parentNode, + name = ofType && elem.nodeName.toLowerCase(), + useCache = !xml && !ofType, + diff = false; + + if ( parent ) { + + // :(first|last|only)-(child|of-type) + if ( simple ) { + while ( dir ) { + node = elem; + while ( ( node = node[ dir ] ) ) { + if ( ofType ? + node.nodeName.toLowerCase() === name : + node.nodeType === 1 ) { + + return false; + } + } + + // Reverse direction for :only-* (if we haven't yet done so) + start = dir = type === "only" && !start && "nextSibling"; + } + return true; + } + + start = [ forward ? parent.firstChild : parent.lastChild ]; + + // non-xml :nth-child(...) stores cache data on `parent` + if ( forward && useCache ) { + + // Seek `elem` from a previously-cached index + + // ...in a gzip-friendly way + node = parent; + outerCache = node[ expando ] || ( node[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ node.uniqueID ] || + ( outerCache[ node.uniqueID ] = {} ); + + cache = uniqueCache[ type ] || []; + nodeIndex = cache[ 0 ] === dirruns && cache[ 1 ]; + diff = nodeIndex && cache[ 2 ]; + node = nodeIndex && parent.childNodes[ nodeIndex ]; + + while ( ( node = ++nodeIndex && node && node[ dir ] || + + // Fallback to seeking `elem` from the start + ( diff = nodeIndex = 0 ) || start.pop() ) ) { + + // When found, cache indexes on `parent` and break + if ( node.nodeType === 1 && ++diff && node === elem ) { + uniqueCache[ type ] = [ dirruns, nodeIndex, diff ]; + break; + } + } + + } else { + + // Use previously-cached element index if available + if ( useCache ) { + + // ...in a gzip-friendly way + node = elem; + outerCache = node[ expando ] || ( node[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ node.uniqueID ] || + ( outerCache[ node.uniqueID ] = {} ); + + cache = uniqueCache[ type ] || []; + nodeIndex = cache[ 0 ] === dirruns && cache[ 1 ]; + diff = nodeIndex; + } + + // xml :nth-child(...) + // or :nth-last-child(...) or :nth(-last)?-of-type(...) + if ( diff === false ) { + + // Use the same loop as above to seek `elem` from the start + while ( ( node = ++nodeIndex && node && node[ dir ] || + ( diff = nodeIndex = 0 ) || start.pop() ) ) { + + if ( ( ofType ? + node.nodeName.toLowerCase() === name : + node.nodeType === 1 ) && + ++diff ) { + + // Cache the index of each encountered element + if ( useCache ) { + outerCache = node[ expando ] || + ( node[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ node.uniqueID ] || + ( outerCache[ node.uniqueID ] = {} ); + + uniqueCache[ type ] = [ dirruns, diff ]; + } + + if ( node === elem ) { + break; + } + } + } + } + } + + // Incorporate the offset, then check against cycle size + diff -= last; + return diff === first || ( diff % first === 0 && diff / first >= 0 ); + } + }; + }, + + "PSEUDO": function( pseudo, argument ) { + + // pseudo-class names are case-insensitive + // http://www.w3.org/TR/selectors/#pseudo-classes + // Prioritize by case sensitivity in case custom pseudos are added with uppercase letters + // Remember that setFilters inherits from pseudos + var args, + fn = Expr.pseudos[ pseudo ] || Expr.setFilters[ pseudo.toLowerCase() ] || + Sizzle.error( "unsupported pseudo: " + pseudo ); + + // The user may use createPseudo to indicate that + // arguments are needed to create the filter function + // just as Sizzle does + if ( fn[ expando ] ) { + return fn( argument ); + } + + // But maintain support for old signatures + if ( fn.length > 1 ) { + args = [ pseudo, pseudo, "", argument ]; + return Expr.setFilters.hasOwnProperty( pseudo.toLowerCase() ) ? + markFunction( function( seed, matches ) { + var idx, + matched = fn( seed, argument ), + i = matched.length; + while ( i-- ) { + idx = indexOf( seed, matched[ i ] ); + seed[ idx ] = !( matches[ idx ] = matched[ i ] ); + } + } ) : + function( elem ) { + return fn( elem, 0, args ); + }; + } + + return fn; + } + }, + + pseudos: { + + // Potentially complex pseudos + "not": markFunction( function( selector ) { + + // Trim the selector passed to compile + // to avoid treating leading and trailing + // spaces as combinators + var input = [], + results = [], + matcher = compile( selector.replace( rtrim, "$1" ) ); + + return matcher[ expando ] ? + markFunction( function( seed, matches, _context, xml ) { + var elem, + unmatched = matcher( seed, null, xml, [] ), + i = seed.length; + + // Match elements unmatched by `matcher` + while ( i-- ) { + if ( ( elem = unmatched[ i ] ) ) { + seed[ i ] = !( matches[ i ] = elem ); + } + } + } ) : + function( elem, _context, xml ) { + input[ 0 ] = elem; + matcher( input, null, xml, results ); + + // Don't keep the element (issue #299) + input[ 0 ] = null; + return !results.pop(); + }; + } ), + + "has": markFunction( function( selector ) { + return function( elem ) { + return Sizzle( selector, elem ).length > 0; + }; + } ), + + "contains": markFunction( function( text ) { + text = text.replace( runescape, funescape ); + return function( elem ) { + return ( elem.textContent || getText( elem ) ).indexOf( text ) > -1; + }; + } ), + + // "Whether an element is represented by a :lang() selector + // is based solely on the element's language value + // being equal to the identifier C, + // or beginning with the identifier C immediately followed by "-". + // The matching of C against the element's language value is performed case-insensitively. + // The identifier C does not have to be a valid language name." + // http://www.w3.org/TR/selectors/#lang-pseudo + "lang": markFunction( function( lang ) { + + // lang value must be a valid identifier + if ( !ridentifier.test( lang || "" ) ) { + Sizzle.error( "unsupported lang: " + lang ); + } + lang = lang.replace( runescape, funescape ).toLowerCase(); + return function( elem ) { + var elemLang; + do { + if ( ( elemLang = documentIsHTML ? + elem.lang : + elem.getAttribute( "xml:lang" ) || elem.getAttribute( "lang" ) ) ) { + + elemLang = elemLang.toLowerCase(); + return elemLang === lang || elemLang.indexOf( lang + "-" ) === 0; + } + } while ( ( elem = elem.parentNode ) && elem.nodeType === 1 ); + return false; + }; + } ), + + // Miscellaneous + "target": function( elem ) { + var hash = window.location && window.location.hash; + return hash && hash.slice( 1 ) === elem.id; + }, + + "root": function( elem ) { + return elem === docElem; + }, + + "focus": function( elem ) { + return elem === document.activeElement && + ( !document.hasFocus || document.hasFocus() ) && + !!( elem.type || elem.href || ~elem.tabIndex ); + }, + + // Boolean properties + "enabled": createDisabledPseudo( false ), + "disabled": createDisabledPseudo( true ), + + "checked": function( elem ) { + + // In CSS3, :checked should return both checked and selected elements + // http://www.w3.org/TR/2011/REC-css3-selectors-20110929/#checked + var nodeName = elem.nodeName.toLowerCase(); + return ( nodeName === "input" && !!elem.checked ) || + ( nodeName === "option" && !!elem.selected ); + }, + + "selected": function( elem ) { + + // Accessing this property makes selected-by-default + // options in Safari work properly + if ( elem.parentNode ) { + // eslint-disable-next-line no-unused-expressions + elem.parentNode.selectedIndex; + } + + return elem.selected === true; + }, + + // Contents + "empty": function( elem ) { + + // http://www.w3.org/TR/selectors/#empty-pseudo + // :empty is negated by element (1) or content nodes (text: 3; cdata: 4; entity ref: 5), + // but not by others (comment: 8; processing instruction: 7; etc.) + // nodeType < 6 works because attributes (2) do not appear as children + for ( elem = elem.firstChild; elem; elem = elem.nextSibling ) { + if ( elem.nodeType < 6 ) { + return false; + } + } + return true; + }, + + "parent": function( elem ) { + return !Expr.pseudos[ "empty" ]( elem ); + }, + + // Element/input types + "header": function( elem ) { + return rheader.test( elem.nodeName ); + }, + + "input": function( elem ) { + return rinputs.test( elem.nodeName ); + }, + + "button": function( elem ) { + var name = elem.nodeName.toLowerCase(); + return name === "input" && elem.type === "button" || name === "button"; + }, + + "text": function( elem ) { + var attr; + return elem.nodeName.toLowerCase() === "input" && + elem.type === "text" && + + // Support: IE<8 + // New HTML5 attribute values (e.g., "search") appear with elem.type === "text" + ( ( attr = elem.getAttribute( "type" ) ) == null || + attr.toLowerCase() === "text" ); + }, + + // Position-in-collection + "first": createPositionalPseudo( function() { + return [ 0 ]; + } ), + + "last": createPositionalPseudo( function( _matchIndexes, length ) { + return [ length - 1 ]; + } ), + + "eq": createPositionalPseudo( function( _matchIndexes, length, argument ) { + return [ argument < 0 ? argument + length : argument ]; + } ), + + "even": createPositionalPseudo( function( matchIndexes, length ) { + var i = 0; + for ( ; i < length; i += 2 ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ), + + "odd": createPositionalPseudo( function( matchIndexes, length ) { + var i = 1; + for ( ; i < length; i += 2 ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ), + + "lt": createPositionalPseudo( function( matchIndexes, length, argument ) { + var i = argument < 0 ? + argument + length : + argument > length ? + length : + argument; + for ( ; --i >= 0; ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ), + + "gt": createPositionalPseudo( function( matchIndexes, length, argument ) { + var i = argument < 0 ? argument + length : argument; + for ( ; ++i < length; ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ) + } +}; + +Expr.pseudos[ "nth" ] = Expr.pseudos[ "eq" ]; + +// Add button/input type pseudos +for ( i in { radio: true, checkbox: true, file: true, password: true, image: true } ) { + Expr.pseudos[ i ] = createInputPseudo( i ); +} +for ( i in { submit: true, reset: true } ) { + Expr.pseudos[ i ] = createButtonPseudo( i ); +} + +// Easy API for creating new setFilters +function setFilters() {} +setFilters.prototype = Expr.filters = Expr.pseudos; +Expr.setFilters = new setFilters(); + +tokenize = Sizzle.tokenize = function( selector, parseOnly ) { + var matched, match, tokens, type, + soFar, groups, preFilters, + cached = tokenCache[ selector + " " ]; + + if ( cached ) { + return parseOnly ? 0 : cached.slice( 0 ); + } + + soFar = selector; + groups = []; + preFilters = Expr.preFilter; + + while ( soFar ) { + + // Comma and first run + if ( !matched || ( match = rcomma.exec( soFar ) ) ) { + if ( match ) { + + // Don't consume trailing commas as valid + soFar = soFar.slice( match[ 0 ].length ) || soFar; + } + groups.push( ( tokens = [] ) ); + } + + matched = false; + + // Combinators + if ( ( match = rcombinators.exec( soFar ) ) ) { + matched = match.shift(); + tokens.push( { + value: matched, + + // Cast descendant combinators to space + type: match[ 0 ].replace( rtrim, " " ) + } ); + soFar = soFar.slice( matched.length ); + } + + // Filters + for ( type in Expr.filter ) { + if ( ( match = matchExpr[ type ].exec( soFar ) ) && ( !preFilters[ type ] || + ( match = preFilters[ type ]( match ) ) ) ) { + matched = match.shift(); + tokens.push( { + value: matched, + type: type, + matches: match + } ); + soFar = soFar.slice( matched.length ); + } + } + + if ( !matched ) { + break; + } + } + + // Return the length of the invalid excess + // if we're just parsing + // Otherwise, throw an error or return tokens + return parseOnly ? + soFar.length : + soFar ? + Sizzle.error( selector ) : + + // Cache the tokens + tokenCache( selector, groups ).slice( 0 ); +}; + +function toSelector( tokens ) { + var i = 0, + len = tokens.length, + selector = ""; + for ( ; i < len; i++ ) { + selector += tokens[ i ].value; + } + return selector; +} + +function addCombinator( matcher, combinator, base ) { + var dir = combinator.dir, + skip = combinator.next, + key = skip || dir, + checkNonElements = base && key === "parentNode", + doneName = done++; + + return combinator.first ? + + // Check against closest ancestor/preceding element + function( elem, context, xml ) { + while ( ( elem = elem[ dir ] ) ) { + if ( elem.nodeType === 1 || checkNonElements ) { + return matcher( elem, context, xml ); + } + } + return false; + } : + + // Check against all ancestor/preceding elements + function( elem, context, xml ) { + var oldCache, uniqueCache, outerCache, + newCache = [ dirruns, doneName ]; + + // We can't set arbitrary data on XML nodes, so they don't benefit from combinator caching + if ( xml ) { + while ( ( elem = elem[ dir ] ) ) { + if ( elem.nodeType === 1 || checkNonElements ) { + if ( matcher( elem, context, xml ) ) { + return true; + } + } + } + } else { + while ( ( elem = elem[ dir ] ) ) { + if ( elem.nodeType === 1 || checkNonElements ) { + outerCache = elem[ expando ] || ( elem[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ elem.uniqueID ] || + ( outerCache[ elem.uniqueID ] = {} ); + + if ( skip && skip === elem.nodeName.toLowerCase() ) { + elem = elem[ dir ] || elem; + } else if ( ( oldCache = uniqueCache[ key ] ) && + oldCache[ 0 ] === dirruns && oldCache[ 1 ] === doneName ) { + + // Assign to newCache so results back-propagate to previous elements + return ( newCache[ 2 ] = oldCache[ 2 ] ); + } else { + + // Reuse newcache so results back-propagate to previous elements + uniqueCache[ key ] = newCache; + + // A match means we're done; a fail means we have to keep checking + if ( ( newCache[ 2 ] = matcher( elem, context, xml ) ) ) { + return true; + } + } + } + } + } + return false; + }; +} + +function elementMatcher( matchers ) { + return matchers.length > 1 ? + function( elem, context, xml ) { + var i = matchers.length; + while ( i-- ) { + if ( !matchers[ i ]( elem, context, xml ) ) { + return false; + } + } + return true; + } : + matchers[ 0 ]; +} + +function multipleContexts( selector, contexts, results ) { + var i = 0, + len = contexts.length; + for ( ; i < len; i++ ) { + Sizzle( selector, contexts[ i ], results ); + } + return results; +} + +function condense( unmatched, map, filter, context, xml ) { + var elem, + newUnmatched = [], + i = 0, + len = unmatched.length, + mapped = map != null; + + for ( ; i < len; i++ ) { + if ( ( elem = unmatched[ i ] ) ) { + if ( !filter || filter( elem, context, xml ) ) { + newUnmatched.push( elem ); + if ( mapped ) { + map.push( i ); + } + } + } + } + + return newUnmatched; +} + +function setMatcher( preFilter, selector, matcher, postFilter, postFinder, postSelector ) { + if ( postFilter && !postFilter[ expando ] ) { + postFilter = setMatcher( postFilter ); + } + if ( postFinder && !postFinder[ expando ] ) { + postFinder = setMatcher( postFinder, postSelector ); + } + return markFunction( function( seed, results, context, xml ) { + var temp, i, elem, + preMap = [], + postMap = [], + preexisting = results.length, + + // Get initial elements from seed or context + elems = seed || multipleContexts( + selector || "*", + context.nodeType ? [ context ] : context, + [] + ), + + // Prefilter to get matcher input, preserving a map for seed-results synchronization + matcherIn = preFilter && ( seed || !selector ) ? + condense( elems, preMap, preFilter, context, xml ) : + elems, + + matcherOut = matcher ? + + // If we have a postFinder, or filtered seed, or non-seed postFilter or preexisting results, + postFinder || ( seed ? preFilter : preexisting || postFilter ) ? + + // ...intermediate processing is necessary + [] : + + // ...otherwise use results directly + results : + matcherIn; + + // Find primary matches + if ( matcher ) { + matcher( matcherIn, matcherOut, context, xml ); + } + + // Apply postFilter + if ( postFilter ) { + temp = condense( matcherOut, postMap ); + postFilter( temp, [], context, xml ); + + // Un-match failing elements by moving them back to matcherIn + i = temp.length; + while ( i-- ) { + if ( ( elem = temp[ i ] ) ) { + matcherOut[ postMap[ i ] ] = !( matcherIn[ postMap[ i ] ] = elem ); + } + } + } + + if ( seed ) { + if ( postFinder || preFilter ) { + if ( postFinder ) { + + // Get the final matcherOut by condensing this intermediate into postFinder contexts + temp = []; + i = matcherOut.length; + while ( i-- ) { + if ( ( elem = matcherOut[ i ] ) ) { + + // Restore matcherIn since elem is not yet a final match + temp.push( ( matcherIn[ i ] = elem ) ); + } + } + postFinder( null, ( matcherOut = [] ), temp, xml ); + } + + // Move matched elements from seed to results to keep them synchronized + i = matcherOut.length; + while ( i-- ) { + if ( ( elem = matcherOut[ i ] ) && + ( temp = postFinder ? indexOf( seed, elem ) : preMap[ i ] ) > -1 ) { + + seed[ temp ] = !( results[ temp ] = elem ); + } + } + } + + // Add elements to results, through postFinder if defined + } else { + matcherOut = condense( + matcherOut === results ? + matcherOut.splice( preexisting, matcherOut.length ) : + matcherOut + ); + if ( postFinder ) { + postFinder( null, results, matcherOut, xml ); + } else { + push.apply( results, matcherOut ); + } + } + } ); +} + +function matcherFromTokens( tokens ) { + var checkContext, matcher, j, + len = tokens.length, + leadingRelative = Expr.relative[ tokens[ 0 ].type ], + implicitRelative = leadingRelative || Expr.relative[ " " ], + i = leadingRelative ? 1 : 0, + + // The foundational matcher ensures that elements are reachable from top-level context(s) + matchContext = addCombinator( function( elem ) { + return elem === checkContext; + }, implicitRelative, true ), + matchAnyContext = addCombinator( function( elem ) { + return indexOf( checkContext, elem ) > -1; + }, implicitRelative, true ), + matchers = [ function( elem, context, xml ) { + var ret = ( !leadingRelative && ( xml || context !== outermostContext ) ) || ( + ( checkContext = context ).nodeType ? + matchContext( elem, context, xml ) : + matchAnyContext( elem, context, xml ) ); + + // Avoid hanging onto element (issue #299) + checkContext = null; + return ret; + } ]; + + for ( ; i < len; i++ ) { + if ( ( matcher = Expr.relative[ tokens[ i ].type ] ) ) { + matchers = [ addCombinator( elementMatcher( matchers ), matcher ) ]; + } else { + matcher = Expr.filter[ tokens[ i ].type ].apply( null, tokens[ i ].matches ); + + // Return special upon seeing a positional matcher + if ( matcher[ expando ] ) { + + // Find the next relative operator (if any) for proper handling + j = ++i; + for ( ; j < len; j++ ) { + if ( Expr.relative[ tokens[ j ].type ] ) { + break; + } + } + return setMatcher( + i > 1 && elementMatcher( matchers ), + i > 1 && toSelector( + + // If the preceding token was a descendant combinator, insert an implicit any-element `*` + tokens + .slice( 0, i - 1 ) + .concat( { value: tokens[ i - 2 ].type === " " ? "*" : "" } ) + ).replace( rtrim, "$1" ), + matcher, + i < j && matcherFromTokens( tokens.slice( i, j ) ), + j < len && matcherFromTokens( ( tokens = tokens.slice( j ) ) ), + j < len && toSelector( tokens ) + ); + } + matchers.push( matcher ); + } + } + + return elementMatcher( matchers ); +} + +function matcherFromGroupMatchers( elementMatchers, setMatchers ) { + var bySet = setMatchers.length > 0, + byElement = elementMatchers.length > 0, + superMatcher = function( seed, context, xml, results, outermost ) { + var elem, j, matcher, + matchedCount = 0, + i = "0", + unmatched = seed && [], + setMatched = [], + contextBackup = outermostContext, + + // We must always have either seed elements or outermost context + elems = seed || byElement && Expr.find[ "TAG" ]( "*", outermost ), + + // Use integer dirruns iff this is the outermost matcher + dirrunsUnique = ( dirruns += contextBackup == null ? 1 : Math.random() || 0.1 ), + len = elems.length; + + if ( outermost ) { + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + outermostContext = context == document || context || outermost; + } + + // Add elements passing elementMatchers directly to results + // Support: IE<9, Safari + // Tolerate NodeList properties (IE: "length"; Safari: ) matching elements by id + for ( ; i !== len && ( elem = elems[ i ] ) != null; i++ ) { + if ( byElement && elem ) { + j = 0; + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( !context && elem.ownerDocument != document ) { + setDocument( elem ); + xml = !documentIsHTML; + } + while ( ( matcher = elementMatchers[ j++ ] ) ) { + if ( matcher( elem, context || document, xml ) ) { + results.push( elem ); + break; + } + } + if ( outermost ) { + dirruns = dirrunsUnique; + } + } + + // Track unmatched elements for set filters + if ( bySet ) { + + // They will have gone through all possible matchers + if ( ( elem = !matcher && elem ) ) { + matchedCount--; + } + + // Lengthen the array for every element, matched or not + if ( seed ) { + unmatched.push( elem ); + } + } + } + + // `i` is now the count of elements visited above, and adding it to `matchedCount` + // makes the latter nonnegative. + matchedCount += i; + + // Apply set filters to unmatched elements + // NOTE: This can be skipped if there are no unmatched elements (i.e., `matchedCount` + // equals `i`), unless we didn't visit _any_ elements in the above loop because we have + // no element matchers and no seed. + // Incrementing an initially-string "0" `i` allows `i` to remain a string only in that + // case, which will result in a "00" `matchedCount` that differs from `i` but is also + // numerically zero. + if ( bySet && i !== matchedCount ) { + j = 0; + while ( ( matcher = setMatchers[ j++ ] ) ) { + matcher( unmatched, setMatched, context, xml ); + } + + if ( seed ) { + + // Reintegrate element matches to eliminate the need for sorting + if ( matchedCount > 0 ) { + while ( i-- ) { + if ( !( unmatched[ i ] || setMatched[ i ] ) ) { + setMatched[ i ] = pop.call( results ); + } + } + } + + // Discard index placeholder values to get only actual matches + setMatched = condense( setMatched ); + } + + // Add matches to results + push.apply( results, setMatched ); + + // Seedless set matches succeeding multiple successful matchers stipulate sorting + if ( outermost && !seed && setMatched.length > 0 && + ( matchedCount + setMatchers.length ) > 1 ) { + + Sizzle.uniqueSort( results ); + } + } + + // Override manipulation of globals by nested matchers + if ( outermost ) { + dirruns = dirrunsUnique; + outermostContext = contextBackup; + } + + return unmatched; + }; + + return bySet ? + markFunction( superMatcher ) : + superMatcher; +} + +compile = Sizzle.compile = function( selector, match /* Internal Use Only */ ) { + var i, + setMatchers = [], + elementMatchers = [], + cached = compilerCache[ selector + " " ]; + + if ( !cached ) { + + // Generate a function of recursive functions that can be used to check each element + if ( !match ) { + match = tokenize( selector ); + } + i = match.length; + while ( i-- ) { + cached = matcherFromTokens( match[ i ] ); + if ( cached[ expando ] ) { + setMatchers.push( cached ); + } else { + elementMatchers.push( cached ); + } + } + + // Cache the compiled function + cached = compilerCache( + selector, + matcherFromGroupMatchers( elementMatchers, setMatchers ) + ); + + // Save selector and tokenization + cached.selector = selector; + } + return cached; +}; + +/** + * A low-level selection function that works with Sizzle's compiled + * selector functions + * @param {String|Function} selector A selector or a pre-compiled + * selector function built with Sizzle.compile + * @param {Element} context + * @param {Array} [results] + * @param {Array} [seed] A set of elements to match against + */ +select = Sizzle.select = function( selector, context, results, seed ) { + var i, tokens, token, type, find, + compiled = typeof selector === "function" && selector, + match = !seed && tokenize( ( selector = compiled.selector || selector ) ); + + results = results || []; + + // Try to minimize operations if there is only one selector in the list and no seed + // (the latter of which guarantees us context) + if ( match.length === 1 ) { + + // Reduce context if the leading compound selector is an ID + tokens = match[ 0 ] = match[ 0 ].slice( 0 ); + if ( tokens.length > 2 && ( token = tokens[ 0 ] ).type === "ID" && + context.nodeType === 9 && documentIsHTML && Expr.relative[ tokens[ 1 ].type ] ) { + + context = ( Expr.find[ "ID" ]( token.matches[ 0 ] + .replace( runescape, funescape ), context ) || [] )[ 0 ]; + if ( !context ) { + return results; + + // Precompiled matchers will still verify ancestry, so step up a level + } else if ( compiled ) { + context = context.parentNode; + } + + selector = selector.slice( tokens.shift().value.length ); + } + + // Fetch a seed set for right-to-left matching + i = matchExpr[ "needsContext" ].test( selector ) ? 0 : tokens.length; + while ( i-- ) { + token = tokens[ i ]; + + // Abort if we hit a combinator + if ( Expr.relative[ ( type = token.type ) ] ) { + break; + } + if ( ( find = Expr.find[ type ] ) ) { + + // Search, expanding context for leading sibling combinators + if ( ( seed = find( + token.matches[ 0 ].replace( runescape, funescape ), + rsibling.test( tokens[ 0 ].type ) && testContext( context.parentNode ) || + context + ) ) ) { + + // If seed is empty or no tokens remain, we can return early + tokens.splice( i, 1 ); + selector = seed.length && toSelector( tokens ); + if ( !selector ) { + push.apply( results, seed ); + return results; + } + + break; + } + } + } + } + + // Compile and execute a filtering function if one is not provided + // Provide `match` to avoid retokenization if we modified the selector above + ( compiled || compile( selector, match ) )( + seed, + context, + !documentIsHTML, + results, + !context || rsibling.test( selector ) && testContext( context.parentNode ) || context + ); + return results; +}; + +// One-time assignments + +// Sort stability +support.sortStable = expando.split( "" ).sort( sortOrder ).join( "" ) === expando; + +// Support: Chrome 14-35+ +// Always assume duplicates if they aren't passed to the comparison function +support.detectDuplicates = !!hasDuplicate; + +// Initialize against the default document +setDocument(); + +// Support: Webkit<537.32 - Safari 6.0.3/Chrome 25 (fixed in Chrome 27) +// Detached nodes confoundingly follow *each other* +support.sortDetached = assert( function( el ) { + + // Should return 1, but returns 4 (following) + return el.compareDocumentPosition( document.createElement( "fieldset" ) ) & 1; +} ); + +// Support: IE<8 +// Prevent attribute/property "interpolation" +// https://msdn.microsoft.com/en-us/library/ms536429%28VS.85%29.aspx +if ( !assert( function( el ) { + el.innerHTML = ""; + return el.firstChild.getAttribute( "href" ) === "#"; +} ) ) { + addHandle( "type|href|height|width", function( elem, name, isXML ) { + if ( !isXML ) { + return elem.getAttribute( name, name.toLowerCase() === "type" ? 1 : 2 ); + } + } ); +} + +// Support: IE<9 +// Use defaultValue in place of getAttribute("value") +if ( !support.attributes || !assert( function( el ) { + el.innerHTML = ""; + el.firstChild.setAttribute( "value", "" ); + return el.firstChild.getAttribute( "value" ) === ""; +} ) ) { + addHandle( "value", function( elem, _name, isXML ) { + if ( !isXML && elem.nodeName.toLowerCase() === "input" ) { + return elem.defaultValue; + } + } ); +} + +// Support: IE<9 +// Use getAttributeNode to fetch booleans when getAttribute lies +if ( !assert( function( el ) { + return el.getAttribute( "disabled" ) == null; +} ) ) { + addHandle( booleans, function( elem, name, isXML ) { + var val; + if ( !isXML ) { + return elem[ name ] === true ? name.toLowerCase() : + ( val = elem.getAttributeNode( name ) ) && val.specified ? + val.value : + null; + } + } ); +} + +return Sizzle; + +} )( window ); + + + +jQuery.find = Sizzle; +jQuery.expr = Sizzle.selectors; + +// Deprecated +jQuery.expr[ ":" ] = jQuery.expr.pseudos; +jQuery.uniqueSort = jQuery.unique = Sizzle.uniqueSort; +jQuery.text = Sizzle.getText; +jQuery.isXMLDoc = Sizzle.isXML; +jQuery.contains = Sizzle.contains; +jQuery.escapeSelector = Sizzle.escape; + + + + +var dir = function( elem, dir, until ) { + var matched = [], + truncate = until !== undefined; + + while ( ( elem = elem[ dir ] ) && elem.nodeType !== 9 ) { + if ( elem.nodeType === 1 ) { + if ( truncate && jQuery( elem ).is( until ) ) { + break; + } + matched.push( elem ); + } + } + return matched; +}; + + +var siblings = function( n, elem ) { + var matched = []; + + for ( ; n; n = n.nextSibling ) { + if ( n.nodeType === 1 && n !== elem ) { + matched.push( n ); + } + } + + return matched; +}; + + +var rneedsContext = jQuery.expr.match.needsContext; + + + +function nodeName( elem, name ) { + + return elem.nodeName && elem.nodeName.toLowerCase() === name.toLowerCase(); + +} +var rsingleTag = ( /^<([a-z][^\/\0>:\x20\t\r\n\f]*)[\x20\t\r\n\f]*\/?>(?:<\/\1>|)$/i ); + + + +// Implement the identical functionality for filter and not +function winnow( elements, qualifier, not ) { + if ( isFunction( qualifier ) ) { + return jQuery.grep( elements, function( elem, i ) { + return !!qualifier.call( elem, i, elem ) !== not; + } ); + } + + // Single element + if ( qualifier.nodeType ) { + return jQuery.grep( elements, function( elem ) { + return ( elem === qualifier ) !== not; + } ); + } + + // Arraylike of elements (jQuery, arguments, Array) + if ( typeof qualifier !== "string" ) { + return jQuery.grep( elements, function( elem ) { + return ( indexOf.call( qualifier, elem ) > -1 ) !== not; + } ); + } + + // Filtered directly for both simple and complex selectors + return jQuery.filter( qualifier, elements, not ); +} + +jQuery.filter = function( expr, elems, not ) { + var elem = elems[ 0 ]; + + if ( not ) { + expr = ":not(" + expr + ")"; + } + + if ( elems.length === 1 && elem.nodeType === 1 ) { + return jQuery.find.matchesSelector( elem, expr ) ? [ elem ] : []; + } + + return jQuery.find.matches( expr, jQuery.grep( elems, function( elem ) { + return elem.nodeType === 1; + } ) ); +}; + +jQuery.fn.extend( { + find: function( selector ) { + var i, ret, + len = this.length, + self = this; + + if ( typeof selector !== "string" ) { + return this.pushStack( jQuery( selector ).filter( function() { + for ( i = 0; i < len; i++ ) { + if ( jQuery.contains( self[ i ], this ) ) { + return true; + } + } + } ) ); + } + + ret = this.pushStack( [] ); + + for ( i = 0; i < len; i++ ) { + jQuery.find( selector, self[ i ], ret ); + } + + return len > 1 ? jQuery.uniqueSort( ret ) : ret; + }, + filter: function( selector ) { + return this.pushStack( winnow( this, selector || [], false ) ); + }, + not: function( selector ) { + return this.pushStack( winnow( this, selector || [], true ) ); + }, + is: function( selector ) { + return !!winnow( + this, + + // If this is a positional/relative selector, check membership in the returned set + // so $("p:first").is("p:last") won't return true for a doc with two "p". + typeof selector === "string" && rneedsContext.test( selector ) ? + jQuery( selector ) : + selector || [], + false + ).length; + } +} ); + + +// Initialize a jQuery object + + +// A central reference to the root jQuery(document) +var rootjQuery, + + // A simple way to check for HTML strings + // Prioritize #id over to avoid XSS via location.hash (#9521) + // Strict HTML recognition (#11290: must start with <) + // Shortcut simple #id case for speed + rquickExpr = /^(?:\s*(<[\w\W]+>)[^>]*|#([\w-]+))$/, + + init = jQuery.fn.init = function( selector, context, root ) { + var match, elem; + + // HANDLE: $(""), $(null), $(undefined), $(false) + if ( !selector ) { + return this; + } + + // Method init() accepts an alternate rootjQuery + // so migrate can support jQuery.sub (gh-2101) + root = root || rootjQuery; + + // Handle HTML strings + if ( typeof selector === "string" ) { + if ( selector[ 0 ] === "<" && + selector[ selector.length - 1 ] === ">" && + selector.length >= 3 ) { + + // Assume that strings that start and end with <> are HTML and skip the regex check + match = [ null, selector, null ]; + + } else { + match = rquickExpr.exec( selector ); + } + + // Match html or make sure no context is specified for #id + if ( match && ( match[ 1 ] || !context ) ) { + + // HANDLE: $(html) -> $(array) + if ( match[ 1 ] ) { + context = context instanceof jQuery ? context[ 0 ] : context; + + // Option to run scripts is true for back-compat + // Intentionally let the error be thrown if parseHTML is not present + jQuery.merge( this, jQuery.parseHTML( + match[ 1 ], + context && context.nodeType ? context.ownerDocument || context : document, + true + ) ); + + // HANDLE: $(html, props) + if ( rsingleTag.test( match[ 1 ] ) && jQuery.isPlainObject( context ) ) { + for ( match in context ) { + + // Properties of context are called as methods if possible + if ( isFunction( this[ match ] ) ) { + this[ match ]( context[ match ] ); + + // ...and otherwise set as attributes + } else { + this.attr( match, context[ match ] ); + } + } + } + + return this; + + // HANDLE: $(#id) + } else { + elem = document.getElementById( match[ 2 ] ); + + if ( elem ) { + + // Inject the element directly into the jQuery object + this[ 0 ] = elem; + this.length = 1; + } + return this; + } + + // HANDLE: $(expr, $(...)) + } else if ( !context || context.jquery ) { + return ( context || root ).find( selector ); + + // HANDLE: $(expr, context) + // (which is just equivalent to: $(context).find(expr) + } else { + return this.constructor( context ).find( selector ); + } + + // HANDLE: $(DOMElement) + } else if ( selector.nodeType ) { + this[ 0 ] = selector; + this.length = 1; + return this; + + // HANDLE: $(function) + // Shortcut for document ready + } else if ( isFunction( selector ) ) { + return root.ready !== undefined ? + root.ready( selector ) : + + // Execute immediately if ready is not present + selector( jQuery ); + } + + return jQuery.makeArray( selector, this ); + }; + +// Give the init function the jQuery prototype for later instantiation +init.prototype = jQuery.fn; + +// Initialize central reference +rootjQuery = jQuery( document ); + + +var rparentsprev = /^(?:parents|prev(?:Until|All))/, + + // Methods guaranteed to produce a unique set when starting from a unique set + guaranteedUnique = { + children: true, + contents: true, + next: true, + prev: true + }; + +jQuery.fn.extend( { + has: function( target ) { + var targets = jQuery( target, this ), + l = targets.length; + + return this.filter( function() { + var i = 0; + for ( ; i < l; i++ ) { + if ( jQuery.contains( this, targets[ i ] ) ) { + return true; + } + } + } ); + }, + + closest: function( selectors, context ) { + var cur, + i = 0, + l = this.length, + matched = [], + targets = typeof selectors !== "string" && jQuery( selectors ); + + // Positional selectors never match, since there's no _selection_ context + if ( !rneedsContext.test( selectors ) ) { + for ( ; i < l; i++ ) { + for ( cur = this[ i ]; cur && cur !== context; cur = cur.parentNode ) { + + // Always skip document fragments + if ( cur.nodeType < 11 && ( targets ? + targets.index( cur ) > -1 : + + // Don't pass non-elements to Sizzle + cur.nodeType === 1 && + jQuery.find.matchesSelector( cur, selectors ) ) ) { + + matched.push( cur ); + break; + } + } + } + } + + return this.pushStack( matched.length > 1 ? jQuery.uniqueSort( matched ) : matched ); + }, + + // Determine the position of an element within the set + index: function( elem ) { + + // No argument, return index in parent + if ( !elem ) { + return ( this[ 0 ] && this[ 0 ].parentNode ) ? this.first().prevAll().length : -1; + } + + // Index in selector + if ( typeof elem === "string" ) { + return indexOf.call( jQuery( elem ), this[ 0 ] ); + } + + // Locate the position of the desired element + return indexOf.call( this, + + // If it receives a jQuery object, the first element is used + elem.jquery ? elem[ 0 ] : elem + ); + }, + + add: function( selector, context ) { + return this.pushStack( + jQuery.uniqueSort( + jQuery.merge( this.get(), jQuery( selector, context ) ) + ) + ); + }, + + addBack: function( selector ) { + return this.add( selector == null ? + this.prevObject : this.prevObject.filter( selector ) + ); + } +} ); + +function sibling( cur, dir ) { + while ( ( cur = cur[ dir ] ) && cur.nodeType !== 1 ) {} + return cur; +} + +jQuery.each( { + parent: function( elem ) { + var parent = elem.parentNode; + return parent && parent.nodeType !== 11 ? parent : null; + }, + parents: function( elem ) { + return dir( elem, "parentNode" ); + }, + parentsUntil: function( elem, _i, until ) { + return dir( elem, "parentNode", until ); + }, + next: function( elem ) { + return sibling( elem, "nextSibling" ); + }, + prev: function( elem ) { + return sibling( elem, "previousSibling" ); + }, + nextAll: function( elem ) { + return dir( elem, "nextSibling" ); + }, + prevAll: function( elem ) { + return dir( elem, "previousSibling" ); + }, + nextUntil: function( elem, _i, until ) { + return dir( elem, "nextSibling", until ); + }, + prevUntil: function( elem, _i, until ) { + return dir( elem, "previousSibling", until ); + }, + siblings: function( elem ) { + return siblings( ( elem.parentNode || {} ).firstChild, elem ); + }, + children: function( elem ) { + return siblings( elem.firstChild ); + }, + contents: function( elem ) { + if ( elem.contentDocument != null && + + // Support: IE 11+ + // elements with no `data` attribute has an object + // `contentDocument` with a `null` prototype. + getProto( elem.contentDocument ) ) { + + return elem.contentDocument; + } + + // Support: IE 9 - 11 only, iOS 7 only, Android Browser <=4.3 only + // Treat the template element as a regular one in browsers that + // don't support it. + if ( nodeName( elem, "template" ) ) { + elem = elem.content || elem; + } + + return jQuery.merge( [], elem.childNodes ); + } +}, function( name, fn ) { + jQuery.fn[ name ] = function( until, selector ) { + var matched = jQuery.map( this, fn, until ); + + if ( name.slice( -5 ) !== "Until" ) { + selector = until; + } + + if ( selector && typeof selector === "string" ) { + matched = jQuery.filter( selector, matched ); + } + + if ( this.length > 1 ) { + + // Remove duplicates + if ( !guaranteedUnique[ name ] ) { + jQuery.uniqueSort( matched ); + } + + // Reverse order for parents* and prev-derivatives + if ( rparentsprev.test( name ) ) { + matched.reverse(); + } + } + + return this.pushStack( matched ); + }; +} ); +var rnothtmlwhite = ( /[^\x20\t\r\n\f]+/g ); + + + +// Convert String-formatted options into Object-formatted ones +function createOptions( options ) { + var object = {}; + jQuery.each( options.match( rnothtmlwhite ) || [], function( _, flag ) { + object[ flag ] = true; + } ); + return object; +} + +/* + * Create a callback list using the following parameters: + * + * options: an optional list of space-separated options that will change how + * the callback list behaves or a more traditional option object + * + * By default a callback list will act like an event callback list and can be + * "fired" multiple times. + * + * Possible options: + * + * once: will ensure the callback list can only be fired once (like a Deferred) + * + * memory: will keep track of previous values and will call any callback added + * after the list has been fired right away with the latest "memorized" + * values (like a Deferred) + * + * unique: will ensure a callback can only be added once (no duplicate in the list) + * + * stopOnFalse: interrupt callings when a callback returns false + * + */ +jQuery.Callbacks = function( options ) { + + // Convert options from String-formatted to Object-formatted if needed + // (we check in cache first) + options = typeof options === "string" ? + createOptions( options ) : + jQuery.extend( {}, options ); + + var // Flag to know if list is currently firing + firing, + + // Last fire value for non-forgettable lists + memory, + + // Flag to know if list was already fired + fired, + + // Flag to prevent firing + locked, + + // Actual callback list + list = [], + + // Queue of execution data for repeatable lists + queue = [], + + // Index of currently firing callback (modified by add/remove as needed) + firingIndex = -1, + + // Fire callbacks + fire = function() { + + // Enforce single-firing + locked = locked || options.once; + + // Execute callbacks for all pending executions, + // respecting firingIndex overrides and runtime changes + fired = firing = true; + for ( ; queue.length; firingIndex = -1 ) { + memory = queue.shift(); + while ( ++firingIndex < list.length ) { + + // Run callback and check for early termination + if ( list[ firingIndex ].apply( memory[ 0 ], memory[ 1 ] ) === false && + options.stopOnFalse ) { + + // Jump to end and forget the data so .add doesn't re-fire + firingIndex = list.length; + memory = false; + } + } + } + + // Forget the data if we're done with it + if ( !options.memory ) { + memory = false; + } + + firing = false; + + // Clean up if we're done firing for good + if ( locked ) { + + // Keep an empty list if we have data for future add calls + if ( memory ) { + list = []; + + // Otherwise, this object is spent + } else { + list = ""; + } + } + }, + + // Actual Callbacks object + self = { + + // Add a callback or a collection of callbacks to the list + add: function() { + if ( list ) { + + // If we have memory from a past run, we should fire after adding + if ( memory && !firing ) { + firingIndex = list.length - 1; + queue.push( memory ); + } + + ( function add( args ) { + jQuery.each( args, function( _, arg ) { + if ( isFunction( arg ) ) { + if ( !options.unique || !self.has( arg ) ) { + list.push( arg ); + } + } else if ( arg && arg.length && toType( arg ) !== "string" ) { + + // Inspect recursively + add( arg ); + } + } ); + } )( arguments ); + + if ( memory && !firing ) { + fire(); + } + } + return this; + }, + + // Remove a callback from the list + remove: function() { + jQuery.each( arguments, function( _, arg ) { + var index; + while ( ( index = jQuery.inArray( arg, list, index ) ) > -1 ) { + list.splice( index, 1 ); + + // Handle firing indexes + if ( index <= firingIndex ) { + firingIndex--; + } + } + } ); + return this; + }, + + // Check if a given callback is in the list. + // If no argument is given, return whether or not list has callbacks attached. + has: function( fn ) { + return fn ? + jQuery.inArray( fn, list ) > -1 : + list.length > 0; + }, + + // Remove all callbacks from the list + empty: function() { + if ( list ) { + list = []; + } + return this; + }, + + // Disable .fire and .add + // Abort any current/pending executions + // Clear all callbacks and values + disable: function() { + locked = queue = []; + list = memory = ""; + return this; + }, + disabled: function() { + return !list; + }, + + // Disable .fire + // Also disable .add unless we have memory (since it would have no effect) + // Abort any pending executions + lock: function() { + locked = queue = []; + if ( !memory && !firing ) { + list = memory = ""; + } + return this; + }, + locked: function() { + return !!locked; + }, + + // Call all callbacks with the given context and arguments + fireWith: function( context, args ) { + if ( !locked ) { + args = args || []; + args = [ context, args.slice ? args.slice() : args ]; + queue.push( args ); + if ( !firing ) { + fire(); + } + } + return this; + }, + + // Call all the callbacks with the given arguments + fire: function() { + self.fireWith( this, arguments ); + return this; + }, + + // To know if the callbacks have already been called at least once + fired: function() { + return !!fired; + } + }; + + return self; +}; + + +function Identity( v ) { + return v; +} +function Thrower( ex ) { + throw ex; +} + +function adoptValue( value, resolve, reject, noValue ) { + var method; + + try { + + // Check for promise aspect first to privilege synchronous behavior + if ( value && isFunction( ( method = value.promise ) ) ) { + method.call( value ).done( resolve ).fail( reject ); + + // Other thenables + } else if ( value && isFunction( ( method = value.then ) ) ) { + method.call( value, resolve, reject ); + + // Other non-thenables + } else { + + // Control `resolve` arguments by letting Array#slice cast boolean `noValue` to integer: + // * false: [ value ].slice( 0 ) => resolve( value ) + // * true: [ value ].slice( 1 ) => resolve() + resolve.apply( undefined, [ value ].slice( noValue ) ); + } + + // For Promises/A+, convert exceptions into rejections + // Since jQuery.when doesn't unwrap thenables, we can skip the extra checks appearing in + // Deferred#then to conditionally suppress rejection. + } catch ( value ) { + + // Support: Android 4.0 only + // Strict mode functions invoked without .call/.apply get global-object context + reject.apply( undefined, [ value ] ); + } +} + +jQuery.extend( { + + Deferred: function( func ) { + var tuples = [ + + // action, add listener, callbacks, + // ... .then handlers, argument index, [final state] + [ "notify", "progress", jQuery.Callbacks( "memory" ), + jQuery.Callbacks( "memory" ), 2 ], + [ "resolve", "done", jQuery.Callbacks( "once memory" ), + jQuery.Callbacks( "once memory" ), 0, "resolved" ], + [ "reject", "fail", jQuery.Callbacks( "once memory" ), + jQuery.Callbacks( "once memory" ), 1, "rejected" ] + ], + state = "pending", + promise = { + state: function() { + return state; + }, + always: function() { + deferred.done( arguments ).fail( arguments ); + return this; + }, + "catch": function( fn ) { + return promise.then( null, fn ); + }, + + // Keep pipe for back-compat + pipe: function( /* fnDone, fnFail, fnProgress */ ) { + var fns = arguments; + + return jQuery.Deferred( function( newDefer ) { + jQuery.each( tuples, function( _i, tuple ) { + + // Map tuples (progress, done, fail) to arguments (done, fail, progress) + var fn = isFunction( fns[ tuple[ 4 ] ] ) && fns[ tuple[ 4 ] ]; + + // deferred.progress(function() { bind to newDefer or newDefer.notify }) + // deferred.done(function() { bind to newDefer or newDefer.resolve }) + // deferred.fail(function() { bind to newDefer or newDefer.reject }) + deferred[ tuple[ 1 ] ]( function() { + var returned = fn && fn.apply( this, arguments ); + if ( returned && isFunction( returned.promise ) ) { + returned.promise() + .progress( newDefer.notify ) + .done( newDefer.resolve ) + .fail( newDefer.reject ); + } else { + newDefer[ tuple[ 0 ] + "With" ]( + this, + fn ? [ returned ] : arguments + ); + } + } ); + } ); + fns = null; + } ).promise(); + }, + then: function( onFulfilled, onRejected, onProgress ) { + var maxDepth = 0; + function resolve( depth, deferred, handler, special ) { + return function() { + var that = this, + args = arguments, + mightThrow = function() { + var returned, then; + + // Support: Promises/A+ section 2.3.3.3.3 + // https://promisesaplus.com/#point-59 + // Ignore double-resolution attempts + if ( depth < maxDepth ) { + return; + } + + returned = handler.apply( that, args ); + + // Support: Promises/A+ section 2.3.1 + // https://promisesaplus.com/#point-48 + if ( returned === deferred.promise() ) { + throw new TypeError( "Thenable self-resolution" ); + } + + // Support: Promises/A+ sections 2.3.3.1, 3.5 + // https://promisesaplus.com/#point-54 + // https://promisesaplus.com/#point-75 + // Retrieve `then` only once + then = returned && + + // Support: Promises/A+ section 2.3.4 + // https://promisesaplus.com/#point-64 + // Only check objects and functions for thenability + ( typeof returned === "object" || + typeof returned === "function" ) && + returned.then; + + // Handle a returned thenable + if ( isFunction( then ) ) { + + // Special processors (notify) just wait for resolution + if ( special ) { + then.call( + returned, + resolve( maxDepth, deferred, Identity, special ), + resolve( maxDepth, deferred, Thrower, special ) + ); + + // Normal processors (resolve) also hook into progress + } else { + + // ...and disregard older resolution values + maxDepth++; + + then.call( + returned, + resolve( maxDepth, deferred, Identity, special ), + resolve( maxDepth, deferred, Thrower, special ), + resolve( maxDepth, deferred, Identity, + deferred.notifyWith ) + ); + } + + // Handle all other returned values + } else { + + // Only substitute handlers pass on context + // and multiple values (non-spec behavior) + if ( handler !== Identity ) { + that = undefined; + args = [ returned ]; + } + + // Process the value(s) + // Default process is resolve + ( special || deferred.resolveWith )( that, args ); + } + }, + + // Only normal processors (resolve) catch and reject exceptions + process = special ? + mightThrow : + function() { + try { + mightThrow(); + } catch ( e ) { + + if ( jQuery.Deferred.exceptionHook ) { + jQuery.Deferred.exceptionHook( e, + process.stackTrace ); + } + + // Support: Promises/A+ section 2.3.3.3.4.1 + // https://promisesaplus.com/#point-61 + // Ignore post-resolution exceptions + if ( depth + 1 >= maxDepth ) { + + // Only substitute handlers pass on context + // and multiple values (non-spec behavior) + if ( handler !== Thrower ) { + that = undefined; + args = [ e ]; + } + + deferred.rejectWith( that, args ); + } + } + }; + + // Support: Promises/A+ section 2.3.3.3.1 + // https://promisesaplus.com/#point-57 + // Re-resolve promises immediately to dodge false rejection from + // subsequent errors + if ( depth ) { + process(); + } else { + + // Call an optional hook to record the stack, in case of exception + // since it's otherwise lost when execution goes async + if ( jQuery.Deferred.getStackHook ) { + process.stackTrace = jQuery.Deferred.getStackHook(); + } + window.setTimeout( process ); + } + }; + } + + return jQuery.Deferred( function( newDefer ) { + + // progress_handlers.add( ... ) + tuples[ 0 ][ 3 ].add( + resolve( + 0, + newDefer, + isFunction( onProgress ) ? + onProgress : + Identity, + newDefer.notifyWith + ) + ); + + // fulfilled_handlers.add( ... ) + tuples[ 1 ][ 3 ].add( + resolve( + 0, + newDefer, + isFunction( onFulfilled ) ? + onFulfilled : + Identity + ) + ); + + // rejected_handlers.add( ... ) + tuples[ 2 ][ 3 ].add( + resolve( + 0, + newDefer, + isFunction( onRejected ) ? + onRejected : + Thrower + ) + ); + } ).promise(); + }, + + // Get a promise for this deferred + // If obj is provided, the promise aspect is added to the object + promise: function( obj ) { + return obj != null ? jQuery.extend( obj, promise ) : promise; + } + }, + deferred = {}; + + // Add list-specific methods + jQuery.each( tuples, function( i, tuple ) { + var list = tuple[ 2 ], + stateString = tuple[ 5 ]; + + // promise.progress = list.add + // promise.done = list.add + // promise.fail = list.add + promise[ tuple[ 1 ] ] = list.add; + + // Handle state + if ( stateString ) { + list.add( + function() { + + // state = "resolved" (i.e., fulfilled) + // state = "rejected" + state = stateString; + }, + + // rejected_callbacks.disable + // fulfilled_callbacks.disable + tuples[ 3 - i ][ 2 ].disable, + + // rejected_handlers.disable + // fulfilled_handlers.disable + tuples[ 3 - i ][ 3 ].disable, + + // progress_callbacks.lock + tuples[ 0 ][ 2 ].lock, + + // progress_handlers.lock + tuples[ 0 ][ 3 ].lock + ); + } + + // progress_handlers.fire + // fulfilled_handlers.fire + // rejected_handlers.fire + list.add( tuple[ 3 ].fire ); + + // deferred.notify = function() { deferred.notifyWith(...) } + // deferred.resolve = function() { deferred.resolveWith(...) } + // deferred.reject = function() { deferred.rejectWith(...) } + deferred[ tuple[ 0 ] ] = function() { + deferred[ tuple[ 0 ] + "With" ]( this === deferred ? undefined : this, arguments ); + return this; + }; + + // deferred.notifyWith = list.fireWith + // deferred.resolveWith = list.fireWith + // deferred.rejectWith = list.fireWith + deferred[ tuple[ 0 ] + "With" ] = list.fireWith; + } ); + + // Make the deferred a promise + promise.promise( deferred ); + + // Call given func if any + if ( func ) { + func.call( deferred, deferred ); + } + + // All done! + return deferred; + }, + + // Deferred helper + when: function( singleValue ) { + var + + // count of uncompleted subordinates + remaining = arguments.length, + + // count of unprocessed arguments + i = remaining, + + // subordinate fulfillment data + resolveContexts = Array( i ), + resolveValues = slice.call( arguments ), + + // the primary Deferred + primary = jQuery.Deferred(), + + // subordinate callback factory + updateFunc = function( i ) { + return function( value ) { + resolveContexts[ i ] = this; + resolveValues[ i ] = arguments.length > 1 ? slice.call( arguments ) : value; + if ( !( --remaining ) ) { + primary.resolveWith( resolveContexts, resolveValues ); + } + }; + }; + + // Single- and empty arguments are adopted like Promise.resolve + if ( remaining <= 1 ) { + adoptValue( singleValue, primary.done( updateFunc( i ) ).resolve, primary.reject, + !remaining ); + + // Use .then() to unwrap secondary thenables (cf. gh-3000) + if ( primary.state() === "pending" || + isFunction( resolveValues[ i ] && resolveValues[ i ].then ) ) { + + return primary.then(); + } + } + + // Multiple arguments are aggregated like Promise.all array elements + while ( i-- ) { + adoptValue( resolveValues[ i ], updateFunc( i ), primary.reject ); + } + + return primary.promise(); + } +} ); + + +// These usually indicate a programmer mistake during development, +// warn about them ASAP rather than swallowing them by default. +var rerrorNames = /^(Eval|Internal|Range|Reference|Syntax|Type|URI)Error$/; + +jQuery.Deferred.exceptionHook = function( error, stack ) { + + // Support: IE 8 - 9 only + // Console exists when dev tools are open, which can happen at any time + if ( window.console && window.console.warn && error && rerrorNames.test( error.name ) ) { + window.console.warn( "jQuery.Deferred exception: " + error.message, error.stack, stack ); + } +}; + + + + +jQuery.readyException = function( error ) { + window.setTimeout( function() { + throw error; + } ); +}; + + + + +// The deferred used on DOM ready +var readyList = jQuery.Deferred(); + +jQuery.fn.ready = function( fn ) { + + readyList + .then( fn ) + + // Wrap jQuery.readyException in a function so that the lookup + // happens at the time of error handling instead of callback + // registration. + .catch( function( error ) { + jQuery.readyException( error ); + } ); + + return this; +}; + +jQuery.extend( { + + // Is the DOM ready to be used? Set to true once it occurs. + isReady: false, + + // A counter to track how many items to wait for before + // the ready event fires. See #6781 + readyWait: 1, + + // Handle when the DOM is ready + ready: function( wait ) { + + // Abort if there are pending holds or we're already ready + if ( wait === true ? --jQuery.readyWait : jQuery.isReady ) { + return; + } + + // Remember that the DOM is ready + jQuery.isReady = true; + + // If a normal DOM Ready event fired, decrement, and wait if need be + if ( wait !== true && --jQuery.readyWait > 0 ) { + return; + } + + // If there are functions bound, to execute + readyList.resolveWith( document, [ jQuery ] ); + } +} ); + +jQuery.ready.then = readyList.then; + +// The ready event handler and self cleanup method +function completed() { + document.removeEventListener( "DOMContentLoaded", completed ); + window.removeEventListener( "load", completed ); + jQuery.ready(); +} + +// Catch cases where $(document).ready() is called +// after the browser event has already occurred. +// Support: IE <=9 - 10 only +// Older IE sometimes signals "interactive" too soon +if ( document.readyState === "complete" || + ( document.readyState !== "loading" && !document.documentElement.doScroll ) ) { + + // Handle it asynchronously to allow scripts the opportunity to delay ready + window.setTimeout( jQuery.ready ); + +} else { + + // Use the handy event callback + document.addEventListener( "DOMContentLoaded", completed ); + + // A fallback to window.onload, that will always work + window.addEventListener( "load", completed ); +} + + + + +// Multifunctional method to get and set values of a collection +// The value/s can optionally be executed if it's a function +var access = function( elems, fn, key, value, chainable, emptyGet, raw ) { + var i = 0, + len = elems.length, + bulk = key == null; + + // Sets many values + if ( toType( key ) === "object" ) { + chainable = true; + for ( i in key ) { + access( elems, fn, i, key[ i ], true, emptyGet, raw ); + } + + // Sets one value + } else if ( value !== undefined ) { + chainable = true; + + if ( !isFunction( value ) ) { + raw = true; + } + + if ( bulk ) { + + // Bulk operations run against the entire set + if ( raw ) { + fn.call( elems, value ); + fn = null; + + // ...except when executing function values + } else { + bulk = fn; + fn = function( elem, _key, value ) { + return bulk.call( jQuery( elem ), value ); + }; + } + } + + if ( fn ) { + for ( ; i < len; i++ ) { + fn( + elems[ i ], key, raw ? + value : + value.call( elems[ i ], i, fn( elems[ i ], key ) ) + ); + } + } + } + + if ( chainable ) { + return elems; + } + + // Gets + if ( bulk ) { + return fn.call( elems ); + } + + return len ? fn( elems[ 0 ], key ) : emptyGet; +}; + + +// Matches dashed string for camelizing +var rmsPrefix = /^-ms-/, + rdashAlpha = /-([a-z])/g; + +// Used by camelCase as callback to replace() +function fcamelCase( _all, letter ) { + return letter.toUpperCase(); +} + +// Convert dashed to camelCase; used by the css and data modules +// Support: IE <=9 - 11, Edge 12 - 15 +// Microsoft forgot to hump their vendor prefix (#9572) +function camelCase( string ) { + return string.replace( rmsPrefix, "ms-" ).replace( rdashAlpha, fcamelCase ); +} +var acceptData = function( owner ) { + + // Accepts only: + // - Node + // - Node.ELEMENT_NODE + // - Node.DOCUMENT_NODE + // - Object + // - Any + return owner.nodeType === 1 || owner.nodeType === 9 || !( +owner.nodeType ); +}; + + + + +function Data() { + this.expando = jQuery.expando + Data.uid++; +} + +Data.uid = 1; + +Data.prototype = { + + cache: function( owner ) { + + // Check if the owner object already has a cache + var value = owner[ this.expando ]; + + // If not, create one + if ( !value ) { + value = {}; + + // We can accept data for non-element nodes in modern browsers, + // but we should not, see #8335. + // Always return an empty object. + if ( acceptData( owner ) ) { + + // If it is a node unlikely to be stringify-ed or looped over + // use plain assignment + if ( owner.nodeType ) { + owner[ this.expando ] = value; + + // Otherwise secure it in a non-enumerable property + // configurable must be true to allow the property to be + // deleted when data is removed + } else { + Object.defineProperty( owner, this.expando, { + value: value, + configurable: true + } ); + } + } + } + + return value; + }, + set: function( owner, data, value ) { + var prop, + cache = this.cache( owner ); + + // Handle: [ owner, key, value ] args + // Always use camelCase key (gh-2257) + if ( typeof data === "string" ) { + cache[ camelCase( data ) ] = value; + + // Handle: [ owner, { properties } ] args + } else { + + // Copy the properties one-by-one to the cache object + for ( prop in data ) { + cache[ camelCase( prop ) ] = data[ prop ]; + } + } + return cache; + }, + get: function( owner, key ) { + return key === undefined ? + this.cache( owner ) : + + // Always use camelCase key (gh-2257) + owner[ this.expando ] && owner[ this.expando ][ camelCase( key ) ]; + }, + access: function( owner, key, value ) { + + // In cases where either: + // + // 1. No key was specified + // 2. A string key was specified, but no value provided + // + // Take the "read" path and allow the get method to determine + // which value to return, respectively either: + // + // 1. The entire cache object + // 2. The data stored at the key + // + if ( key === undefined || + ( ( key && typeof key === "string" ) && value === undefined ) ) { + + return this.get( owner, key ); + } + + // When the key is not a string, or both a key and value + // are specified, set or extend (existing objects) with either: + // + // 1. An object of properties + // 2. A key and value + // + this.set( owner, key, value ); + + // Since the "set" path can have two possible entry points + // return the expected data based on which path was taken[*] + return value !== undefined ? value : key; + }, + remove: function( owner, key ) { + var i, + cache = owner[ this.expando ]; + + if ( cache === undefined ) { + return; + } + + if ( key !== undefined ) { + + // Support array or space separated string of keys + if ( Array.isArray( key ) ) { + + // If key is an array of keys... + // We always set camelCase keys, so remove that. + key = key.map( camelCase ); + } else { + key = camelCase( key ); + + // If a key with the spaces exists, use it. + // Otherwise, create an array by matching non-whitespace + key = key in cache ? + [ key ] : + ( key.match( rnothtmlwhite ) || [] ); + } + + i = key.length; + + while ( i-- ) { + delete cache[ key[ i ] ]; + } + } + + // Remove the expando if there's no more data + if ( key === undefined || jQuery.isEmptyObject( cache ) ) { + + // Support: Chrome <=35 - 45 + // Webkit & Blink performance suffers when deleting properties + // from DOM nodes, so set to undefined instead + // https://bugs.chromium.org/p/chromium/issues/detail?id=378607 (bug restricted) + if ( owner.nodeType ) { + owner[ this.expando ] = undefined; + } else { + delete owner[ this.expando ]; + } + } + }, + hasData: function( owner ) { + var cache = owner[ this.expando ]; + return cache !== undefined && !jQuery.isEmptyObject( cache ); + } +}; +var dataPriv = new Data(); + +var dataUser = new Data(); + + + +// Implementation Summary +// +// 1. Enforce API surface and semantic compatibility with 1.9.x branch +// 2. Improve the module's maintainability by reducing the storage +// paths to a single mechanism. +// 3. Use the same single mechanism to support "private" and "user" data. +// 4. _Never_ expose "private" data to user code (TODO: Drop _data, _removeData) +// 5. Avoid exposing implementation details on user objects (eg. expando properties) +// 6. Provide a clear path for implementation upgrade to WeakMap in 2014 + +var rbrace = /^(?:\{[\w\W]*\}|\[[\w\W]*\])$/, + rmultiDash = /[A-Z]/g; + +function getData( data ) { + if ( data === "true" ) { + return true; + } + + if ( data === "false" ) { + return false; + } + + if ( data === "null" ) { + return null; + } + + // Only convert to a number if it doesn't change the string + if ( data === +data + "" ) { + return +data; + } + + if ( rbrace.test( data ) ) { + return JSON.parse( data ); + } + + return data; +} + +function dataAttr( elem, key, data ) { + var name; + + // If nothing was found internally, try to fetch any + // data from the HTML5 data-* attribute + if ( data === undefined && elem.nodeType === 1 ) { + name = "data-" + key.replace( rmultiDash, "-$&" ).toLowerCase(); + data = elem.getAttribute( name ); + + if ( typeof data === "string" ) { + try { + data = getData( data ); + } catch ( e ) {} + + // Make sure we set the data so it isn't changed later + dataUser.set( elem, key, data ); + } else { + data = undefined; + } + } + return data; +} + +jQuery.extend( { + hasData: function( elem ) { + return dataUser.hasData( elem ) || dataPriv.hasData( elem ); + }, + + data: function( elem, name, data ) { + return dataUser.access( elem, name, data ); + }, + + removeData: function( elem, name ) { + dataUser.remove( elem, name ); + }, + + // TODO: Now that all calls to _data and _removeData have been replaced + // with direct calls to dataPriv methods, these can be deprecated. + _data: function( elem, name, data ) { + return dataPriv.access( elem, name, data ); + }, + + _removeData: function( elem, name ) { + dataPriv.remove( elem, name ); + } +} ); + +jQuery.fn.extend( { + data: function( key, value ) { + var i, name, data, + elem = this[ 0 ], + attrs = elem && elem.attributes; + + // Gets all values + if ( key === undefined ) { + if ( this.length ) { + data = dataUser.get( elem ); + + if ( elem.nodeType === 1 && !dataPriv.get( elem, "hasDataAttrs" ) ) { + i = attrs.length; + while ( i-- ) { + + // Support: IE 11 only + // The attrs elements can be null (#14894) + if ( attrs[ i ] ) { + name = attrs[ i ].name; + if ( name.indexOf( "data-" ) === 0 ) { + name = camelCase( name.slice( 5 ) ); + dataAttr( elem, name, data[ name ] ); + } + } + } + dataPriv.set( elem, "hasDataAttrs", true ); + } + } + + return data; + } + + // Sets multiple values + if ( typeof key === "object" ) { + return this.each( function() { + dataUser.set( this, key ); + } ); + } + + return access( this, function( value ) { + var data; + + // The calling jQuery object (element matches) is not empty + // (and therefore has an element appears at this[ 0 ]) and the + // `value` parameter was not undefined. An empty jQuery object + // will result in `undefined` for elem = this[ 0 ] which will + // throw an exception if an attempt to read a data cache is made. + if ( elem && value === undefined ) { + + // Attempt to get data from the cache + // The key will always be camelCased in Data + data = dataUser.get( elem, key ); + if ( data !== undefined ) { + return data; + } + + // Attempt to "discover" the data in + // HTML5 custom data-* attrs + data = dataAttr( elem, key ); + if ( data !== undefined ) { + return data; + } + + // We tried really hard, but the data doesn't exist. + return; + } + + // Set the data... + this.each( function() { + + // We always store the camelCased key + dataUser.set( this, key, value ); + } ); + }, null, value, arguments.length > 1, null, true ); + }, + + removeData: function( key ) { + return this.each( function() { + dataUser.remove( this, key ); + } ); + } +} ); + + +jQuery.extend( { + queue: function( elem, type, data ) { + var queue; + + if ( elem ) { + type = ( type || "fx" ) + "queue"; + queue = dataPriv.get( elem, type ); + + // Speed up dequeue by getting out quickly if this is just a lookup + if ( data ) { + if ( !queue || Array.isArray( data ) ) { + queue = dataPriv.access( elem, type, jQuery.makeArray( data ) ); + } else { + queue.push( data ); + } + } + return queue || []; + } + }, + + dequeue: function( elem, type ) { + type = type || "fx"; + + var queue = jQuery.queue( elem, type ), + startLength = queue.length, + fn = queue.shift(), + hooks = jQuery._queueHooks( elem, type ), + next = function() { + jQuery.dequeue( elem, type ); + }; + + // If the fx queue is dequeued, always remove the progress sentinel + if ( fn === "inprogress" ) { + fn = queue.shift(); + startLength--; + } + + if ( fn ) { + + // Add a progress sentinel to prevent the fx queue from being + // automatically dequeued + if ( type === "fx" ) { + queue.unshift( "inprogress" ); + } + + // Clear up the last queue stop function + delete hooks.stop; + fn.call( elem, next, hooks ); + } + + if ( !startLength && hooks ) { + hooks.empty.fire(); + } + }, + + // Not public - generate a queueHooks object, or return the current one + _queueHooks: function( elem, type ) { + var key = type + "queueHooks"; + return dataPriv.get( elem, key ) || dataPriv.access( elem, key, { + empty: jQuery.Callbacks( "once memory" ).add( function() { + dataPriv.remove( elem, [ type + "queue", key ] ); + } ) + } ); + } +} ); + +jQuery.fn.extend( { + queue: function( type, data ) { + var setter = 2; + + if ( typeof type !== "string" ) { + data = type; + type = "fx"; + setter--; + } + + if ( arguments.length < setter ) { + return jQuery.queue( this[ 0 ], type ); + } + + return data === undefined ? + this : + this.each( function() { + var queue = jQuery.queue( this, type, data ); + + // Ensure a hooks for this queue + jQuery._queueHooks( this, type ); + + if ( type === "fx" && queue[ 0 ] !== "inprogress" ) { + jQuery.dequeue( this, type ); + } + } ); + }, + dequeue: function( type ) { + return this.each( function() { + jQuery.dequeue( this, type ); + } ); + }, + clearQueue: function( type ) { + return this.queue( type || "fx", [] ); + }, + + // Get a promise resolved when queues of a certain type + // are emptied (fx is the type by default) + promise: function( type, obj ) { + var tmp, + count = 1, + defer = jQuery.Deferred(), + elements = this, + i = this.length, + resolve = function() { + if ( !( --count ) ) { + defer.resolveWith( elements, [ elements ] ); + } + }; + + if ( typeof type !== "string" ) { + obj = type; + type = undefined; + } + type = type || "fx"; + + while ( i-- ) { + tmp = dataPriv.get( elements[ i ], type + "queueHooks" ); + if ( tmp && tmp.empty ) { + count++; + tmp.empty.add( resolve ); + } + } + resolve(); + return defer.promise( obj ); + } +} ); +var pnum = ( /[+-]?(?:\d*\.|)\d+(?:[eE][+-]?\d+|)/ ).source; + +var rcssNum = new RegExp( "^(?:([+-])=|)(" + pnum + ")([a-z%]*)$", "i" ); + + +var cssExpand = [ "Top", "Right", "Bottom", "Left" ]; + +var documentElement = document.documentElement; + + + + var isAttached = function( elem ) { + return jQuery.contains( elem.ownerDocument, elem ); + }, + composed = { composed: true }; + + // Support: IE 9 - 11+, Edge 12 - 18+, iOS 10.0 - 10.2 only + // Check attachment across shadow DOM boundaries when possible (gh-3504) + // Support: iOS 10.0-10.2 only + // Early iOS 10 versions support `attachShadow` but not `getRootNode`, + // leading to errors. We need to check for `getRootNode`. + if ( documentElement.getRootNode ) { + isAttached = function( elem ) { + return jQuery.contains( elem.ownerDocument, elem ) || + elem.getRootNode( composed ) === elem.ownerDocument; + }; + } +var isHiddenWithinTree = function( elem, el ) { + + // isHiddenWithinTree might be called from jQuery#filter function; + // in that case, element will be second argument + elem = el || elem; + + // Inline style trumps all + return elem.style.display === "none" || + elem.style.display === "" && + + // Otherwise, check computed style + // Support: Firefox <=43 - 45 + // Disconnected elements can have computed display: none, so first confirm that elem is + // in the document. + isAttached( elem ) && + + jQuery.css( elem, "display" ) === "none"; + }; + + + +function adjustCSS( elem, prop, valueParts, tween ) { + var adjusted, scale, + maxIterations = 20, + currentValue = tween ? + function() { + return tween.cur(); + } : + function() { + return jQuery.css( elem, prop, "" ); + }, + initial = currentValue(), + unit = valueParts && valueParts[ 3 ] || ( jQuery.cssNumber[ prop ] ? "" : "px" ), + + // Starting value computation is required for potential unit mismatches + initialInUnit = elem.nodeType && + ( jQuery.cssNumber[ prop ] || unit !== "px" && +initial ) && + rcssNum.exec( jQuery.css( elem, prop ) ); + + if ( initialInUnit && initialInUnit[ 3 ] !== unit ) { + + // Support: Firefox <=54 + // Halve the iteration target value to prevent interference from CSS upper bounds (gh-2144) + initial = initial / 2; + + // Trust units reported by jQuery.css + unit = unit || initialInUnit[ 3 ]; + + // Iteratively approximate from a nonzero starting point + initialInUnit = +initial || 1; + + while ( maxIterations-- ) { + + // Evaluate and update our best guess (doubling guesses that zero out). + // Finish if the scale equals or crosses 1 (making the old*new product non-positive). + jQuery.style( elem, prop, initialInUnit + unit ); + if ( ( 1 - scale ) * ( 1 - ( scale = currentValue() / initial || 0.5 ) ) <= 0 ) { + maxIterations = 0; + } + initialInUnit = initialInUnit / scale; + + } + + initialInUnit = initialInUnit * 2; + jQuery.style( elem, prop, initialInUnit + unit ); + + // Make sure we update the tween properties later on + valueParts = valueParts || []; + } + + if ( valueParts ) { + initialInUnit = +initialInUnit || +initial || 0; + + // Apply relative offset (+=/-=) if specified + adjusted = valueParts[ 1 ] ? + initialInUnit + ( valueParts[ 1 ] + 1 ) * valueParts[ 2 ] : + +valueParts[ 2 ]; + if ( tween ) { + tween.unit = unit; + tween.start = initialInUnit; + tween.end = adjusted; + } + } + return adjusted; +} + + +var defaultDisplayMap = {}; + +function getDefaultDisplay( elem ) { + var temp, + doc = elem.ownerDocument, + nodeName = elem.nodeName, + display = defaultDisplayMap[ nodeName ]; + + if ( display ) { + return display; + } + + temp = doc.body.appendChild( doc.createElement( nodeName ) ); + display = jQuery.css( temp, "display" ); + + temp.parentNode.removeChild( temp ); + + if ( display === "none" ) { + display = "block"; + } + defaultDisplayMap[ nodeName ] = display; + + return display; +} + +function showHide( elements, show ) { + var display, elem, + values = [], + index = 0, + length = elements.length; + + // Determine new display value for elements that need to change + for ( ; index < length; index++ ) { + elem = elements[ index ]; + if ( !elem.style ) { + continue; + } + + display = elem.style.display; + if ( show ) { + + // Since we force visibility upon cascade-hidden elements, an immediate (and slow) + // check is required in this first loop unless we have a nonempty display value (either + // inline or about-to-be-restored) + if ( display === "none" ) { + values[ index ] = dataPriv.get( elem, "display" ) || null; + if ( !values[ index ] ) { + elem.style.display = ""; + } + } + if ( elem.style.display === "" && isHiddenWithinTree( elem ) ) { + values[ index ] = getDefaultDisplay( elem ); + } + } else { + if ( display !== "none" ) { + values[ index ] = "none"; + + // Remember what we're overwriting + dataPriv.set( elem, "display", display ); + } + } + } + + // Set the display of the elements in a second loop to avoid constant reflow + for ( index = 0; index < length; index++ ) { + if ( values[ index ] != null ) { + elements[ index ].style.display = values[ index ]; + } + } + + return elements; +} + +jQuery.fn.extend( { + show: function() { + return showHide( this, true ); + }, + hide: function() { + return showHide( this ); + }, + toggle: function( state ) { + if ( typeof state === "boolean" ) { + return state ? this.show() : this.hide(); + } + + return this.each( function() { + if ( isHiddenWithinTree( this ) ) { + jQuery( this ).show(); + } else { + jQuery( this ).hide(); + } + } ); + } +} ); +var rcheckableType = ( /^(?:checkbox|radio)$/i ); + +var rtagName = ( /<([a-z][^\/\0>\x20\t\r\n\f]*)/i ); + +var rscriptType = ( /^$|^module$|\/(?:java|ecma)script/i ); + + + +( function() { + var fragment = document.createDocumentFragment(), + div = fragment.appendChild( document.createElement( "div" ) ), + input = document.createElement( "input" ); + + // Support: Android 4.0 - 4.3 only + // Check state lost if the name is set (#11217) + // Support: Windows Web Apps (WWA) + // `name` and `type` must use .setAttribute for WWA (#14901) + input.setAttribute( "type", "radio" ); + input.setAttribute( "checked", "checked" ); + input.setAttribute( "name", "t" ); + + div.appendChild( input ); + + // Support: Android <=4.1 only + // Older WebKit doesn't clone checked state correctly in fragments + support.checkClone = div.cloneNode( true ).cloneNode( true ).lastChild.checked; + + // Support: IE <=11 only + // Make sure textarea (and checkbox) defaultValue is properly cloned + div.innerHTML = ""; + support.noCloneChecked = !!div.cloneNode( true ).lastChild.defaultValue; + + // Support: IE <=9 only + // IE <=9 replaces "; + support.option = !!div.lastChild; +} )(); + + +// We have to close these tags to support XHTML (#13200) +var wrapMap = { + + // XHTML parsers do not magically insert elements in the + // same way that tag soup parsers do. So we cannot shorten + // this by omitting or other required elements. + thead: [ 1, "", "
    " ], + col: [ 2, "", "
    " ], + tr: [ 2, "", "
    " ], + td: [ 3, "", "
    " ], + + _default: [ 0, "", "" ] +}; + +wrapMap.tbody = wrapMap.tfoot = wrapMap.colgroup = wrapMap.caption = wrapMap.thead; +wrapMap.th = wrapMap.td; + +// Support: IE <=9 only +if ( !support.option ) { + wrapMap.optgroup = wrapMap.option = [ 1, "" ]; +} + + +function getAll( context, tag ) { + + // Support: IE <=9 - 11 only + // Use typeof to avoid zero-argument method invocation on host objects (#15151) + var ret; + + if ( typeof context.getElementsByTagName !== "undefined" ) { + ret = context.getElementsByTagName( tag || "*" ); + + } else if ( typeof context.querySelectorAll !== "undefined" ) { + ret = context.querySelectorAll( tag || "*" ); + + } else { + ret = []; + } + + if ( tag === undefined || tag && nodeName( context, tag ) ) { + return jQuery.merge( [ context ], ret ); + } + + return ret; +} + + +// Mark scripts as having already been evaluated +function setGlobalEval( elems, refElements ) { + var i = 0, + l = elems.length; + + for ( ; i < l; i++ ) { + dataPriv.set( + elems[ i ], + "globalEval", + !refElements || dataPriv.get( refElements[ i ], "globalEval" ) + ); + } +} + + +var rhtml = /<|&#?\w+;/; + +function buildFragment( elems, context, scripts, selection, ignored ) { + var elem, tmp, tag, wrap, attached, j, + fragment = context.createDocumentFragment(), + nodes = [], + i = 0, + l = elems.length; + + for ( ; i < l; i++ ) { + elem = elems[ i ]; + + if ( elem || elem === 0 ) { + + // Add nodes directly + if ( toType( elem ) === "object" ) { + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + jQuery.merge( nodes, elem.nodeType ? [ elem ] : elem ); + + // Convert non-html into a text node + } else if ( !rhtml.test( elem ) ) { + nodes.push( context.createTextNode( elem ) ); + + // Convert html into DOM nodes + } else { + tmp = tmp || fragment.appendChild( context.createElement( "div" ) ); + + // Deserialize a standard representation + tag = ( rtagName.exec( elem ) || [ "", "" ] )[ 1 ].toLowerCase(); + wrap = wrapMap[ tag ] || wrapMap._default; + tmp.innerHTML = wrap[ 1 ] + jQuery.htmlPrefilter( elem ) + wrap[ 2 ]; + + // Descend through wrappers to the right content + j = wrap[ 0 ]; + while ( j-- ) { + tmp = tmp.lastChild; + } + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + jQuery.merge( nodes, tmp.childNodes ); + + // Remember the top-level container + tmp = fragment.firstChild; + + // Ensure the created nodes are orphaned (#12392) + tmp.textContent = ""; + } + } + } + + // Remove wrapper from fragment + fragment.textContent = ""; + + i = 0; + while ( ( elem = nodes[ i++ ] ) ) { + + // Skip elements already in the context collection (trac-4087) + if ( selection && jQuery.inArray( elem, selection ) > -1 ) { + if ( ignored ) { + ignored.push( elem ); + } + continue; + } + + attached = isAttached( elem ); + + // Append to fragment + tmp = getAll( fragment.appendChild( elem ), "script" ); + + // Preserve script evaluation history + if ( attached ) { + setGlobalEval( tmp ); + } + + // Capture executables + if ( scripts ) { + j = 0; + while ( ( elem = tmp[ j++ ] ) ) { + if ( rscriptType.test( elem.type || "" ) ) { + scripts.push( elem ); + } + } + } + } + + return fragment; +} + + +var rtypenamespace = /^([^.]*)(?:\.(.+)|)/; + +function returnTrue() { + return true; +} + +function returnFalse() { + return false; +} + +// Support: IE <=9 - 11+ +// focus() and blur() are asynchronous, except when they are no-op. +// So expect focus to be synchronous when the element is already active, +// and blur to be synchronous when the element is not already active. +// (focus and blur are always synchronous in other supported browsers, +// this just defines when we can count on it). +function expectSync( elem, type ) { + return ( elem === safeActiveElement() ) === ( type === "focus" ); +} + +// Support: IE <=9 only +// Accessing document.activeElement can throw unexpectedly +// https://bugs.jquery.com/ticket/13393 +function safeActiveElement() { + try { + return document.activeElement; + } catch ( err ) { } +} + +function on( elem, types, selector, data, fn, one ) { + var origFn, type; + + // Types can be a map of types/handlers + if ( typeof types === "object" ) { + + // ( types-Object, selector, data ) + if ( typeof selector !== "string" ) { + + // ( types-Object, data ) + data = data || selector; + selector = undefined; + } + for ( type in types ) { + on( elem, type, selector, data, types[ type ], one ); + } + return elem; + } + + if ( data == null && fn == null ) { + + // ( types, fn ) + fn = selector; + data = selector = undefined; + } else if ( fn == null ) { + if ( typeof selector === "string" ) { + + // ( types, selector, fn ) + fn = data; + data = undefined; + } else { + + // ( types, data, fn ) + fn = data; + data = selector; + selector = undefined; + } + } + if ( fn === false ) { + fn = returnFalse; + } else if ( !fn ) { + return elem; + } + + if ( one === 1 ) { + origFn = fn; + fn = function( event ) { + + // Can use an empty set, since event contains the info + jQuery().off( event ); + return origFn.apply( this, arguments ); + }; + + // Use same guid so caller can remove using origFn + fn.guid = origFn.guid || ( origFn.guid = jQuery.guid++ ); + } + return elem.each( function() { + jQuery.event.add( this, types, fn, data, selector ); + } ); +} + +/* + * Helper functions for managing events -- not part of the public interface. + * Props to Dean Edwards' addEvent library for many of the ideas. + */ +jQuery.event = { + + global: {}, + + add: function( elem, types, handler, data, selector ) { + + var handleObjIn, eventHandle, tmp, + events, t, handleObj, + special, handlers, type, namespaces, origType, + elemData = dataPriv.get( elem ); + + // Only attach events to objects that accept data + if ( !acceptData( elem ) ) { + return; + } + + // Caller can pass in an object of custom data in lieu of the handler + if ( handler.handler ) { + handleObjIn = handler; + handler = handleObjIn.handler; + selector = handleObjIn.selector; + } + + // Ensure that invalid selectors throw exceptions at attach time + // Evaluate against documentElement in case elem is a non-element node (e.g., document) + if ( selector ) { + jQuery.find.matchesSelector( documentElement, selector ); + } + + // Make sure that the handler has a unique ID, used to find/remove it later + if ( !handler.guid ) { + handler.guid = jQuery.guid++; + } + + // Init the element's event structure and main handler, if this is the first + if ( !( events = elemData.events ) ) { + events = elemData.events = Object.create( null ); + } + if ( !( eventHandle = elemData.handle ) ) { + eventHandle = elemData.handle = function( e ) { + + // Discard the second event of a jQuery.event.trigger() and + // when an event is called after a page has unloaded + return typeof jQuery !== "undefined" && jQuery.event.triggered !== e.type ? + jQuery.event.dispatch.apply( elem, arguments ) : undefined; + }; + } + + // Handle multiple events separated by a space + types = ( types || "" ).match( rnothtmlwhite ) || [ "" ]; + t = types.length; + while ( t-- ) { + tmp = rtypenamespace.exec( types[ t ] ) || []; + type = origType = tmp[ 1 ]; + namespaces = ( tmp[ 2 ] || "" ).split( "." ).sort(); + + // There *must* be a type, no attaching namespace-only handlers + if ( !type ) { + continue; + } + + // If event changes its type, use the special event handlers for the changed type + special = jQuery.event.special[ type ] || {}; + + // If selector defined, determine special event api type, otherwise given type + type = ( selector ? special.delegateType : special.bindType ) || type; + + // Update special based on newly reset type + special = jQuery.event.special[ type ] || {}; + + // handleObj is passed to all event handlers + handleObj = jQuery.extend( { + type: type, + origType: origType, + data: data, + handler: handler, + guid: handler.guid, + selector: selector, + needsContext: selector && jQuery.expr.match.needsContext.test( selector ), + namespace: namespaces.join( "." ) + }, handleObjIn ); + + // Init the event handler queue if we're the first + if ( !( handlers = events[ type ] ) ) { + handlers = events[ type ] = []; + handlers.delegateCount = 0; + + // Only use addEventListener if the special events handler returns false + if ( !special.setup || + special.setup.call( elem, data, namespaces, eventHandle ) === false ) { + + if ( elem.addEventListener ) { + elem.addEventListener( type, eventHandle ); + } + } + } + + if ( special.add ) { + special.add.call( elem, handleObj ); + + if ( !handleObj.handler.guid ) { + handleObj.handler.guid = handler.guid; + } + } + + // Add to the element's handler list, delegates in front + if ( selector ) { + handlers.splice( handlers.delegateCount++, 0, handleObj ); + } else { + handlers.push( handleObj ); + } + + // Keep track of which events have ever been used, for event optimization + jQuery.event.global[ type ] = true; + } + + }, + + // Detach an event or set of events from an element + remove: function( elem, types, handler, selector, mappedTypes ) { + + var j, origCount, tmp, + events, t, handleObj, + special, handlers, type, namespaces, origType, + elemData = dataPriv.hasData( elem ) && dataPriv.get( elem ); + + if ( !elemData || !( events = elemData.events ) ) { + return; + } + + // Once for each type.namespace in types; type may be omitted + types = ( types || "" ).match( rnothtmlwhite ) || [ "" ]; + t = types.length; + while ( t-- ) { + tmp = rtypenamespace.exec( types[ t ] ) || []; + type = origType = tmp[ 1 ]; + namespaces = ( tmp[ 2 ] || "" ).split( "." ).sort(); + + // Unbind all events (on this namespace, if provided) for the element + if ( !type ) { + for ( type in events ) { + jQuery.event.remove( elem, type + types[ t ], handler, selector, true ); + } + continue; + } + + special = jQuery.event.special[ type ] || {}; + type = ( selector ? special.delegateType : special.bindType ) || type; + handlers = events[ type ] || []; + tmp = tmp[ 2 ] && + new RegExp( "(^|\\.)" + namespaces.join( "\\.(?:.*\\.|)" ) + "(\\.|$)" ); + + // Remove matching events + origCount = j = handlers.length; + while ( j-- ) { + handleObj = handlers[ j ]; + + if ( ( mappedTypes || origType === handleObj.origType ) && + ( !handler || handler.guid === handleObj.guid ) && + ( !tmp || tmp.test( handleObj.namespace ) ) && + ( !selector || selector === handleObj.selector || + selector === "**" && handleObj.selector ) ) { + handlers.splice( j, 1 ); + + if ( handleObj.selector ) { + handlers.delegateCount--; + } + if ( special.remove ) { + special.remove.call( elem, handleObj ); + } + } + } + + // Remove generic event handler if we removed something and no more handlers exist + // (avoids potential for endless recursion during removal of special event handlers) + if ( origCount && !handlers.length ) { + if ( !special.teardown || + special.teardown.call( elem, namespaces, elemData.handle ) === false ) { + + jQuery.removeEvent( elem, type, elemData.handle ); + } + + delete events[ type ]; + } + } + + // Remove data and the expando if it's no longer used + if ( jQuery.isEmptyObject( events ) ) { + dataPriv.remove( elem, "handle events" ); + } + }, + + dispatch: function( nativeEvent ) { + + var i, j, ret, matched, handleObj, handlerQueue, + args = new Array( arguments.length ), + + // Make a writable jQuery.Event from the native event object + event = jQuery.event.fix( nativeEvent ), + + handlers = ( + dataPriv.get( this, "events" ) || Object.create( null ) + )[ event.type ] || [], + special = jQuery.event.special[ event.type ] || {}; + + // Use the fix-ed jQuery.Event rather than the (read-only) native event + args[ 0 ] = event; + + for ( i = 1; i < arguments.length; i++ ) { + args[ i ] = arguments[ i ]; + } + + event.delegateTarget = this; + + // Call the preDispatch hook for the mapped type, and let it bail if desired + if ( special.preDispatch && special.preDispatch.call( this, event ) === false ) { + return; + } + + // Determine handlers + handlerQueue = jQuery.event.handlers.call( this, event, handlers ); + + // Run delegates first; they may want to stop propagation beneath us + i = 0; + while ( ( matched = handlerQueue[ i++ ] ) && !event.isPropagationStopped() ) { + event.currentTarget = matched.elem; + + j = 0; + while ( ( handleObj = matched.handlers[ j++ ] ) && + !event.isImmediatePropagationStopped() ) { + + // If the event is namespaced, then each handler is only invoked if it is + // specially universal or its namespaces are a superset of the event's. + if ( !event.rnamespace || handleObj.namespace === false || + event.rnamespace.test( handleObj.namespace ) ) { + + event.handleObj = handleObj; + event.data = handleObj.data; + + ret = ( ( jQuery.event.special[ handleObj.origType ] || {} ).handle || + handleObj.handler ).apply( matched.elem, args ); + + if ( ret !== undefined ) { + if ( ( event.result = ret ) === false ) { + event.preventDefault(); + event.stopPropagation(); + } + } + } + } + } + + // Call the postDispatch hook for the mapped type + if ( special.postDispatch ) { + special.postDispatch.call( this, event ); + } + + return event.result; + }, + + handlers: function( event, handlers ) { + var i, handleObj, sel, matchedHandlers, matchedSelectors, + handlerQueue = [], + delegateCount = handlers.delegateCount, + cur = event.target; + + // Find delegate handlers + if ( delegateCount && + + // Support: IE <=9 + // Black-hole SVG instance trees (trac-13180) + cur.nodeType && + + // Support: Firefox <=42 + // Suppress spec-violating clicks indicating a non-primary pointer button (trac-3861) + // https://www.w3.org/TR/DOM-Level-3-Events/#event-type-click + // Support: IE 11 only + // ...but not arrow key "clicks" of radio inputs, which can have `button` -1 (gh-2343) + !( event.type === "click" && event.button >= 1 ) ) { + + for ( ; cur !== this; cur = cur.parentNode || this ) { + + // Don't check non-elements (#13208) + // Don't process clicks on disabled elements (#6911, #8165, #11382, #11764) + if ( cur.nodeType === 1 && !( event.type === "click" && cur.disabled === true ) ) { + matchedHandlers = []; + matchedSelectors = {}; + for ( i = 0; i < delegateCount; i++ ) { + handleObj = handlers[ i ]; + + // Don't conflict with Object.prototype properties (#13203) + sel = handleObj.selector + " "; + + if ( matchedSelectors[ sel ] === undefined ) { + matchedSelectors[ sel ] = handleObj.needsContext ? + jQuery( sel, this ).index( cur ) > -1 : + jQuery.find( sel, this, null, [ cur ] ).length; + } + if ( matchedSelectors[ sel ] ) { + matchedHandlers.push( handleObj ); + } + } + if ( matchedHandlers.length ) { + handlerQueue.push( { elem: cur, handlers: matchedHandlers } ); + } + } + } + } + + // Add the remaining (directly-bound) handlers + cur = this; + if ( delegateCount < handlers.length ) { + handlerQueue.push( { elem: cur, handlers: handlers.slice( delegateCount ) } ); + } + + return handlerQueue; + }, + + addProp: function( name, hook ) { + Object.defineProperty( jQuery.Event.prototype, name, { + enumerable: true, + configurable: true, + + get: isFunction( hook ) ? + function() { + if ( this.originalEvent ) { + return hook( this.originalEvent ); + } + } : + function() { + if ( this.originalEvent ) { + return this.originalEvent[ name ]; + } + }, + + set: function( value ) { + Object.defineProperty( this, name, { + enumerable: true, + configurable: true, + writable: true, + value: value + } ); + } + } ); + }, + + fix: function( originalEvent ) { + return originalEvent[ jQuery.expando ] ? + originalEvent : + new jQuery.Event( originalEvent ); + }, + + special: { + load: { + + // Prevent triggered image.load events from bubbling to window.load + noBubble: true + }, + click: { + + // Utilize native event to ensure correct state for checkable inputs + setup: function( data ) { + + // For mutual compressibility with _default, replace `this` access with a local var. + // `|| data` is dead code meant only to preserve the variable through minification. + var el = this || data; + + // Claim the first handler + if ( rcheckableType.test( el.type ) && + el.click && nodeName( el, "input" ) ) { + + // dataPriv.set( el, "click", ... ) + leverageNative( el, "click", returnTrue ); + } + + // Return false to allow normal processing in the caller + return false; + }, + trigger: function( data ) { + + // For mutual compressibility with _default, replace `this` access with a local var. + // `|| data` is dead code meant only to preserve the variable through minification. + var el = this || data; + + // Force setup before triggering a click + if ( rcheckableType.test( el.type ) && + el.click && nodeName( el, "input" ) ) { + + leverageNative( el, "click" ); + } + + // Return non-false to allow normal event-path propagation + return true; + }, + + // For cross-browser consistency, suppress native .click() on links + // Also prevent it if we're currently inside a leveraged native-event stack + _default: function( event ) { + var target = event.target; + return rcheckableType.test( target.type ) && + target.click && nodeName( target, "input" ) && + dataPriv.get( target, "click" ) || + nodeName( target, "a" ); + } + }, + + beforeunload: { + postDispatch: function( event ) { + + // Support: Firefox 20+ + // Firefox doesn't alert if the returnValue field is not set. + if ( event.result !== undefined && event.originalEvent ) { + event.originalEvent.returnValue = event.result; + } + } + } + } +}; + +// Ensure the presence of an event listener that handles manually-triggered +// synthetic events by interrupting progress until reinvoked in response to +// *native* events that it fires directly, ensuring that state changes have +// already occurred before other listeners are invoked. +function leverageNative( el, type, expectSync ) { + + // Missing expectSync indicates a trigger call, which must force setup through jQuery.event.add + if ( !expectSync ) { + if ( dataPriv.get( el, type ) === undefined ) { + jQuery.event.add( el, type, returnTrue ); + } + return; + } + + // Register the controller as a special universal handler for all event namespaces + dataPriv.set( el, type, false ); + jQuery.event.add( el, type, { + namespace: false, + handler: function( event ) { + var notAsync, result, + saved = dataPriv.get( this, type ); + + if ( ( event.isTrigger & 1 ) && this[ type ] ) { + + // Interrupt processing of the outer synthetic .trigger()ed event + // Saved data should be false in such cases, but might be a leftover capture object + // from an async native handler (gh-4350) + if ( !saved.length ) { + + // Store arguments for use when handling the inner native event + // There will always be at least one argument (an event object), so this array + // will not be confused with a leftover capture object. + saved = slice.call( arguments ); + dataPriv.set( this, type, saved ); + + // Trigger the native event and capture its result + // Support: IE <=9 - 11+ + // focus() and blur() are asynchronous + notAsync = expectSync( this, type ); + this[ type ](); + result = dataPriv.get( this, type ); + if ( saved !== result || notAsync ) { + dataPriv.set( this, type, false ); + } else { + result = {}; + } + if ( saved !== result ) { + + // Cancel the outer synthetic event + event.stopImmediatePropagation(); + event.preventDefault(); + + // Support: Chrome 86+ + // In Chrome, if an element having a focusout handler is blurred by + // clicking outside of it, it invokes the handler synchronously. If + // that handler calls `.remove()` on the element, the data is cleared, + // leaving `result` undefined. We need to guard against this. + return result && result.value; + } + + // If this is an inner synthetic event for an event with a bubbling surrogate + // (focus or blur), assume that the surrogate already propagated from triggering the + // native event and prevent that from happening again here. + // This technically gets the ordering wrong w.r.t. to `.trigger()` (in which the + // bubbling surrogate propagates *after* the non-bubbling base), but that seems + // less bad than duplication. + } else if ( ( jQuery.event.special[ type ] || {} ).delegateType ) { + event.stopPropagation(); + } + + // If this is a native event triggered above, everything is now in order + // Fire an inner synthetic event with the original arguments + } else if ( saved.length ) { + + // ...and capture the result + dataPriv.set( this, type, { + value: jQuery.event.trigger( + + // Support: IE <=9 - 11+ + // Extend with the prototype to reset the above stopImmediatePropagation() + jQuery.extend( saved[ 0 ], jQuery.Event.prototype ), + saved.slice( 1 ), + this + ) + } ); + + // Abort handling of the native event + event.stopImmediatePropagation(); + } + } + } ); +} + +jQuery.removeEvent = function( elem, type, handle ) { + + // This "if" is needed for plain objects + if ( elem.removeEventListener ) { + elem.removeEventListener( type, handle ); + } +}; + +jQuery.Event = function( src, props ) { + + // Allow instantiation without the 'new' keyword + if ( !( this instanceof jQuery.Event ) ) { + return new jQuery.Event( src, props ); + } + + // Event object + if ( src && src.type ) { + this.originalEvent = src; + this.type = src.type; + + // Events bubbling up the document may have been marked as prevented + // by a handler lower down the tree; reflect the correct value. + this.isDefaultPrevented = src.defaultPrevented || + src.defaultPrevented === undefined && + + // Support: Android <=2.3 only + src.returnValue === false ? + returnTrue : + returnFalse; + + // Create target properties + // Support: Safari <=6 - 7 only + // Target should not be a text node (#504, #13143) + this.target = ( src.target && src.target.nodeType === 3 ) ? + src.target.parentNode : + src.target; + + this.currentTarget = src.currentTarget; + this.relatedTarget = src.relatedTarget; + + // Event type + } else { + this.type = src; + } + + // Put explicitly provided properties onto the event object + if ( props ) { + jQuery.extend( this, props ); + } + + // Create a timestamp if incoming event doesn't have one + this.timeStamp = src && src.timeStamp || Date.now(); + + // Mark it as fixed + this[ jQuery.expando ] = true; +}; + +// jQuery.Event is based on DOM3 Events as specified by the ECMAScript Language Binding +// https://www.w3.org/TR/2003/WD-DOM-Level-3-Events-20030331/ecma-script-binding.html +jQuery.Event.prototype = { + constructor: jQuery.Event, + isDefaultPrevented: returnFalse, + isPropagationStopped: returnFalse, + isImmediatePropagationStopped: returnFalse, + isSimulated: false, + + preventDefault: function() { + var e = this.originalEvent; + + this.isDefaultPrevented = returnTrue; + + if ( e && !this.isSimulated ) { + e.preventDefault(); + } + }, + stopPropagation: function() { + var e = this.originalEvent; + + this.isPropagationStopped = returnTrue; + + if ( e && !this.isSimulated ) { + e.stopPropagation(); + } + }, + stopImmediatePropagation: function() { + var e = this.originalEvent; + + this.isImmediatePropagationStopped = returnTrue; + + if ( e && !this.isSimulated ) { + e.stopImmediatePropagation(); + } + + this.stopPropagation(); + } +}; + +// Includes all common event props including KeyEvent and MouseEvent specific props +jQuery.each( { + altKey: true, + bubbles: true, + cancelable: true, + changedTouches: true, + ctrlKey: true, + detail: true, + eventPhase: true, + metaKey: true, + pageX: true, + pageY: true, + shiftKey: true, + view: true, + "char": true, + code: true, + charCode: true, + key: true, + keyCode: true, + button: true, + buttons: true, + clientX: true, + clientY: true, + offsetX: true, + offsetY: true, + pointerId: true, + pointerType: true, + screenX: true, + screenY: true, + targetTouches: true, + toElement: true, + touches: true, + which: true +}, jQuery.event.addProp ); + +jQuery.each( { focus: "focusin", blur: "focusout" }, function( type, delegateType ) { + jQuery.event.special[ type ] = { + + // Utilize native event if possible so blur/focus sequence is correct + setup: function() { + + // Claim the first handler + // dataPriv.set( this, "focus", ... ) + // dataPriv.set( this, "blur", ... ) + leverageNative( this, type, expectSync ); + + // Return false to allow normal processing in the caller + return false; + }, + trigger: function() { + + // Force setup before trigger + leverageNative( this, type ); + + // Return non-false to allow normal event-path propagation + return true; + }, + + // Suppress native focus or blur as it's already being fired + // in leverageNative. + _default: function() { + return true; + }, + + delegateType: delegateType + }; +} ); + +// Create mouseenter/leave events using mouseover/out and event-time checks +// so that event delegation works in jQuery. +// Do the same for pointerenter/pointerleave and pointerover/pointerout +// +// Support: Safari 7 only +// Safari sends mouseenter too often; see: +// https://bugs.chromium.org/p/chromium/issues/detail?id=470258 +// for the description of the bug (it existed in older Chrome versions as well). +jQuery.each( { + mouseenter: "mouseover", + mouseleave: "mouseout", + pointerenter: "pointerover", + pointerleave: "pointerout" +}, function( orig, fix ) { + jQuery.event.special[ orig ] = { + delegateType: fix, + bindType: fix, + + handle: function( event ) { + var ret, + target = this, + related = event.relatedTarget, + handleObj = event.handleObj; + + // For mouseenter/leave call the handler if related is outside the target. + // NB: No relatedTarget if the mouse left/entered the browser window + if ( !related || ( related !== target && !jQuery.contains( target, related ) ) ) { + event.type = handleObj.origType; + ret = handleObj.handler.apply( this, arguments ); + event.type = fix; + } + return ret; + } + }; +} ); + +jQuery.fn.extend( { + + on: function( types, selector, data, fn ) { + return on( this, types, selector, data, fn ); + }, + one: function( types, selector, data, fn ) { + return on( this, types, selector, data, fn, 1 ); + }, + off: function( types, selector, fn ) { + var handleObj, type; + if ( types && types.preventDefault && types.handleObj ) { + + // ( event ) dispatched jQuery.Event + handleObj = types.handleObj; + jQuery( types.delegateTarget ).off( + handleObj.namespace ? + handleObj.origType + "." + handleObj.namespace : + handleObj.origType, + handleObj.selector, + handleObj.handler + ); + return this; + } + if ( typeof types === "object" ) { + + // ( types-object [, selector] ) + for ( type in types ) { + this.off( type, selector, types[ type ] ); + } + return this; + } + if ( selector === false || typeof selector === "function" ) { + + // ( types [, fn] ) + fn = selector; + selector = undefined; + } + if ( fn === false ) { + fn = returnFalse; + } + return this.each( function() { + jQuery.event.remove( this, types, fn, selector ); + } ); + } +} ); + + +var + + // Support: IE <=10 - 11, Edge 12 - 13 only + // In IE/Edge using regex groups here causes severe slowdowns. + // See https://connect.microsoft.com/IE/feedback/details/1736512/ + rnoInnerhtml = /\s*$/g; + +// Prefer a tbody over its parent table for containing new rows +function manipulationTarget( elem, content ) { + if ( nodeName( elem, "table" ) && + nodeName( content.nodeType !== 11 ? content : content.firstChild, "tr" ) ) { + + return jQuery( elem ).children( "tbody" )[ 0 ] || elem; + } + + return elem; +} + +// Replace/restore the type attribute of script elements for safe DOM manipulation +function disableScript( elem ) { + elem.type = ( elem.getAttribute( "type" ) !== null ) + "/" + elem.type; + return elem; +} +function restoreScript( elem ) { + if ( ( elem.type || "" ).slice( 0, 5 ) === "true/" ) { + elem.type = elem.type.slice( 5 ); + } else { + elem.removeAttribute( "type" ); + } + + return elem; +} + +function cloneCopyEvent( src, dest ) { + var i, l, type, pdataOld, udataOld, udataCur, events; + + if ( dest.nodeType !== 1 ) { + return; + } + + // 1. Copy private data: events, handlers, etc. + if ( dataPriv.hasData( src ) ) { + pdataOld = dataPriv.get( src ); + events = pdataOld.events; + + if ( events ) { + dataPriv.remove( dest, "handle events" ); + + for ( type in events ) { + for ( i = 0, l = events[ type ].length; i < l; i++ ) { + jQuery.event.add( dest, type, events[ type ][ i ] ); + } + } + } + } + + // 2. Copy user data + if ( dataUser.hasData( src ) ) { + udataOld = dataUser.access( src ); + udataCur = jQuery.extend( {}, udataOld ); + + dataUser.set( dest, udataCur ); + } +} + +// Fix IE bugs, see support tests +function fixInput( src, dest ) { + var nodeName = dest.nodeName.toLowerCase(); + + // Fails to persist the checked state of a cloned checkbox or radio button. + if ( nodeName === "input" && rcheckableType.test( src.type ) ) { + dest.checked = src.checked; + + // Fails to return the selected option to the default selected state when cloning options + } else if ( nodeName === "input" || nodeName === "textarea" ) { + dest.defaultValue = src.defaultValue; + } +} + +function domManip( collection, args, callback, ignored ) { + + // Flatten any nested arrays + args = flat( args ); + + var fragment, first, scripts, hasScripts, node, doc, + i = 0, + l = collection.length, + iNoClone = l - 1, + value = args[ 0 ], + valueIsFunction = isFunction( value ); + + // We can't cloneNode fragments that contain checked, in WebKit + if ( valueIsFunction || + ( l > 1 && typeof value === "string" && + !support.checkClone && rchecked.test( value ) ) ) { + return collection.each( function( index ) { + var self = collection.eq( index ); + if ( valueIsFunction ) { + args[ 0 ] = value.call( this, index, self.html() ); + } + domManip( self, args, callback, ignored ); + } ); + } + + if ( l ) { + fragment = buildFragment( args, collection[ 0 ].ownerDocument, false, collection, ignored ); + first = fragment.firstChild; + + if ( fragment.childNodes.length === 1 ) { + fragment = first; + } + + // Require either new content or an interest in ignored elements to invoke the callback + if ( first || ignored ) { + scripts = jQuery.map( getAll( fragment, "script" ), disableScript ); + hasScripts = scripts.length; + + // Use the original fragment for the last item + // instead of the first because it can end up + // being emptied incorrectly in certain situations (#8070). + for ( ; i < l; i++ ) { + node = fragment; + + if ( i !== iNoClone ) { + node = jQuery.clone( node, true, true ); + + // Keep references to cloned scripts for later restoration + if ( hasScripts ) { + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + jQuery.merge( scripts, getAll( node, "script" ) ); + } + } + + callback.call( collection[ i ], node, i ); + } + + if ( hasScripts ) { + doc = scripts[ scripts.length - 1 ].ownerDocument; + + // Reenable scripts + jQuery.map( scripts, restoreScript ); + + // Evaluate executable scripts on first document insertion + for ( i = 0; i < hasScripts; i++ ) { + node = scripts[ i ]; + if ( rscriptType.test( node.type || "" ) && + !dataPriv.access( node, "globalEval" ) && + jQuery.contains( doc, node ) ) { + + if ( node.src && ( node.type || "" ).toLowerCase() !== "module" ) { + + // Optional AJAX dependency, but won't run scripts if not present + if ( jQuery._evalUrl && !node.noModule ) { + jQuery._evalUrl( node.src, { + nonce: node.nonce || node.getAttribute( "nonce" ) + }, doc ); + } + } else { + DOMEval( node.textContent.replace( rcleanScript, "" ), node, doc ); + } + } + } + } + } + } + + return collection; +} + +function remove( elem, selector, keepData ) { + var node, + nodes = selector ? jQuery.filter( selector, elem ) : elem, + i = 0; + + for ( ; ( node = nodes[ i ] ) != null; i++ ) { + if ( !keepData && node.nodeType === 1 ) { + jQuery.cleanData( getAll( node ) ); + } + + if ( node.parentNode ) { + if ( keepData && isAttached( node ) ) { + setGlobalEval( getAll( node, "script" ) ); + } + node.parentNode.removeChild( node ); + } + } + + return elem; +} + +jQuery.extend( { + htmlPrefilter: function( html ) { + return html; + }, + + clone: function( elem, dataAndEvents, deepDataAndEvents ) { + var i, l, srcElements, destElements, + clone = elem.cloneNode( true ), + inPage = isAttached( elem ); + + // Fix IE cloning issues + if ( !support.noCloneChecked && ( elem.nodeType === 1 || elem.nodeType === 11 ) && + !jQuery.isXMLDoc( elem ) ) { + + // We eschew Sizzle here for performance reasons: https://jsperf.com/getall-vs-sizzle/2 + destElements = getAll( clone ); + srcElements = getAll( elem ); + + for ( i = 0, l = srcElements.length; i < l; i++ ) { + fixInput( srcElements[ i ], destElements[ i ] ); + } + } + + // Copy the events from the original to the clone + if ( dataAndEvents ) { + if ( deepDataAndEvents ) { + srcElements = srcElements || getAll( elem ); + destElements = destElements || getAll( clone ); + + for ( i = 0, l = srcElements.length; i < l; i++ ) { + cloneCopyEvent( srcElements[ i ], destElements[ i ] ); + } + } else { + cloneCopyEvent( elem, clone ); + } + } + + // Preserve script evaluation history + destElements = getAll( clone, "script" ); + if ( destElements.length > 0 ) { + setGlobalEval( destElements, !inPage && getAll( elem, "script" ) ); + } + + // Return the cloned set + return clone; + }, + + cleanData: function( elems ) { + var data, elem, type, + special = jQuery.event.special, + i = 0; + + for ( ; ( elem = elems[ i ] ) !== undefined; i++ ) { + if ( acceptData( elem ) ) { + if ( ( data = elem[ dataPriv.expando ] ) ) { + if ( data.events ) { + for ( type in data.events ) { + if ( special[ type ] ) { + jQuery.event.remove( elem, type ); + + // This is a shortcut to avoid jQuery.event.remove's overhead + } else { + jQuery.removeEvent( elem, type, data.handle ); + } + } + } + + // Support: Chrome <=35 - 45+ + // Assign undefined instead of using delete, see Data#remove + elem[ dataPriv.expando ] = undefined; + } + if ( elem[ dataUser.expando ] ) { + + // Support: Chrome <=35 - 45+ + // Assign undefined instead of using delete, see Data#remove + elem[ dataUser.expando ] = undefined; + } + } + } + } +} ); + +jQuery.fn.extend( { + detach: function( selector ) { + return remove( this, selector, true ); + }, + + remove: function( selector ) { + return remove( this, selector ); + }, + + text: function( value ) { + return access( this, function( value ) { + return value === undefined ? + jQuery.text( this ) : + this.empty().each( function() { + if ( this.nodeType === 1 || this.nodeType === 11 || this.nodeType === 9 ) { + this.textContent = value; + } + } ); + }, null, value, arguments.length ); + }, + + append: function() { + return domManip( this, arguments, function( elem ) { + if ( this.nodeType === 1 || this.nodeType === 11 || this.nodeType === 9 ) { + var target = manipulationTarget( this, elem ); + target.appendChild( elem ); + } + } ); + }, + + prepend: function() { + return domManip( this, arguments, function( elem ) { + if ( this.nodeType === 1 || this.nodeType === 11 || this.nodeType === 9 ) { + var target = manipulationTarget( this, elem ); + target.insertBefore( elem, target.firstChild ); + } + } ); + }, + + before: function() { + return domManip( this, arguments, function( elem ) { + if ( this.parentNode ) { + this.parentNode.insertBefore( elem, this ); + } + } ); + }, + + after: function() { + return domManip( this, arguments, function( elem ) { + if ( this.parentNode ) { + this.parentNode.insertBefore( elem, this.nextSibling ); + } + } ); + }, + + empty: function() { + var elem, + i = 0; + + for ( ; ( elem = this[ i ] ) != null; i++ ) { + if ( elem.nodeType === 1 ) { + + // Prevent memory leaks + jQuery.cleanData( getAll( elem, false ) ); + + // Remove any remaining nodes + elem.textContent = ""; + } + } + + return this; + }, + + clone: function( dataAndEvents, deepDataAndEvents ) { + dataAndEvents = dataAndEvents == null ? false : dataAndEvents; + deepDataAndEvents = deepDataAndEvents == null ? dataAndEvents : deepDataAndEvents; + + return this.map( function() { + return jQuery.clone( this, dataAndEvents, deepDataAndEvents ); + } ); + }, + + html: function( value ) { + return access( this, function( value ) { + var elem = this[ 0 ] || {}, + i = 0, + l = this.length; + + if ( value === undefined && elem.nodeType === 1 ) { + return elem.innerHTML; + } + + // See if we can take a shortcut and just use innerHTML + if ( typeof value === "string" && !rnoInnerhtml.test( value ) && + !wrapMap[ ( rtagName.exec( value ) || [ "", "" ] )[ 1 ].toLowerCase() ] ) { + + value = jQuery.htmlPrefilter( value ); + + try { + for ( ; i < l; i++ ) { + elem = this[ i ] || {}; + + // Remove element nodes and prevent memory leaks + if ( elem.nodeType === 1 ) { + jQuery.cleanData( getAll( elem, false ) ); + elem.innerHTML = value; + } + } + + elem = 0; + + // If using innerHTML throws an exception, use the fallback method + } catch ( e ) {} + } + + if ( elem ) { + this.empty().append( value ); + } + }, null, value, arguments.length ); + }, + + replaceWith: function() { + var ignored = []; + + // Make the changes, replacing each non-ignored context element with the new content + return domManip( this, arguments, function( elem ) { + var parent = this.parentNode; + + if ( jQuery.inArray( this, ignored ) < 0 ) { + jQuery.cleanData( getAll( this ) ); + if ( parent ) { + parent.replaceChild( elem, this ); + } + } + + // Force callback invocation + }, ignored ); + } +} ); + +jQuery.each( { + appendTo: "append", + prependTo: "prepend", + insertBefore: "before", + insertAfter: "after", + replaceAll: "replaceWith" +}, function( name, original ) { + jQuery.fn[ name ] = function( selector ) { + var elems, + ret = [], + insert = jQuery( selector ), + last = insert.length - 1, + i = 0; + + for ( ; i <= last; i++ ) { + elems = i === last ? this : this.clone( true ); + jQuery( insert[ i ] )[ original ]( elems ); + + // Support: Android <=4.0 only, PhantomJS 1 only + // .get() because push.apply(_, arraylike) throws on ancient WebKit + push.apply( ret, elems.get() ); + } + + return this.pushStack( ret ); + }; +} ); +var rnumnonpx = new RegExp( "^(" + pnum + ")(?!px)[a-z%]+$", "i" ); + +var getStyles = function( elem ) { + + // Support: IE <=11 only, Firefox <=30 (#15098, #14150) + // IE throws on elements created in popups + // FF meanwhile throws on frame elements through "defaultView.getComputedStyle" + var view = elem.ownerDocument.defaultView; + + if ( !view || !view.opener ) { + view = window; + } + + return view.getComputedStyle( elem ); + }; + +var swap = function( elem, options, callback ) { + var ret, name, + old = {}; + + // Remember the old values, and insert the new ones + for ( name in options ) { + old[ name ] = elem.style[ name ]; + elem.style[ name ] = options[ name ]; + } + + ret = callback.call( elem ); + + // Revert the old values + for ( name in options ) { + elem.style[ name ] = old[ name ]; + } + + return ret; +}; + + +var rboxStyle = new RegExp( cssExpand.join( "|" ), "i" ); + + + +( function() { + + // Executing both pixelPosition & boxSizingReliable tests require only one layout + // so they're executed at the same time to save the second computation. + function computeStyleTests() { + + // This is a singleton, we need to execute it only once + if ( !div ) { + return; + } + + container.style.cssText = "position:absolute;left:-11111px;width:60px;" + + "margin-top:1px;padding:0;border:0"; + div.style.cssText = + "position:relative;display:block;box-sizing:border-box;overflow:scroll;" + + "margin:auto;border:1px;padding:1px;" + + "width:60%;top:1%"; + documentElement.appendChild( container ).appendChild( div ); + + var divStyle = window.getComputedStyle( div ); + pixelPositionVal = divStyle.top !== "1%"; + + // Support: Android 4.0 - 4.3 only, Firefox <=3 - 44 + reliableMarginLeftVal = roundPixelMeasures( divStyle.marginLeft ) === 12; + + // Support: Android 4.0 - 4.3 only, Safari <=9.1 - 10.1, iOS <=7.0 - 9.3 + // Some styles come back with percentage values, even though they shouldn't + div.style.right = "60%"; + pixelBoxStylesVal = roundPixelMeasures( divStyle.right ) === 36; + + // Support: IE 9 - 11 only + // Detect misreporting of content dimensions for box-sizing:border-box elements + boxSizingReliableVal = roundPixelMeasures( divStyle.width ) === 36; + + // Support: IE 9 only + // Detect overflow:scroll screwiness (gh-3699) + // Support: Chrome <=64 + // Don't get tricked when zoom affects offsetWidth (gh-4029) + div.style.position = "absolute"; + scrollboxSizeVal = roundPixelMeasures( div.offsetWidth / 3 ) === 12; + + documentElement.removeChild( container ); + + // Nullify the div so it wouldn't be stored in the memory and + // it will also be a sign that checks already performed + div = null; + } + + function roundPixelMeasures( measure ) { + return Math.round( parseFloat( measure ) ); + } + + var pixelPositionVal, boxSizingReliableVal, scrollboxSizeVal, pixelBoxStylesVal, + reliableTrDimensionsVal, reliableMarginLeftVal, + container = document.createElement( "div" ), + div = document.createElement( "div" ); + + // Finish early in limited (non-browser) environments + if ( !div.style ) { + return; + } + + // Support: IE <=9 - 11 only + // Style of cloned element affects source element cloned (#8908) + div.style.backgroundClip = "content-box"; + div.cloneNode( true ).style.backgroundClip = ""; + support.clearCloneStyle = div.style.backgroundClip === "content-box"; + + jQuery.extend( support, { + boxSizingReliable: function() { + computeStyleTests(); + return boxSizingReliableVal; + }, + pixelBoxStyles: function() { + computeStyleTests(); + return pixelBoxStylesVal; + }, + pixelPosition: function() { + computeStyleTests(); + return pixelPositionVal; + }, + reliableMarginLeft: function() { + computeStyleTests(); + return reliableMarginLeftVal; + }, + scrollboxSize: function() { + computeStyleTests(); + return scrollboxSizeVal; + }, + + // Support: IE 9 - 11+, Edge 15 - 18+ + // IE/Edge misreport `getComputedStyle` of table rows with width/height + // set in CSS while `offset*` properties report correct values. + // Behavior in IE 9 is more subtle than in newer versions & it passes + // some versions of this test; make sure not to make it pass there! + // + // Support: Firefox 70+ + // Only Firefox includes border widths + // in computed dimensions. (gh-4529) + reliableTrDimensions: function() { + var table, tr, trChild, trStyle; + if ( reliableTrDimensionsVal == null ) { + table = document.createElement( "table" ); + tr = document.createElement( "tr" ); + trChild = document.createElement( "div" ); + + table.style.cssText = "position:absolute;left:-11111px;border-collapse:separate"; + tr.style.cssText = "border:1px solid"; + + // Support: Chrome 86+ + // Height set through cssText does not get applied. + // Computed height then comes back as 0. + tr.style.height = "1px"; + trChild.style.height = "9px"; + + // Support: Android 8 Chrome 86+ + // In our bodyBackground.html iframe, + // display for all div elements is set to "inline", + // which causes a problem only in Android 8 Chrome 86. + // Ensuring the div is display: block + // gets around this issue. + trChild.style.display = "block"; + + documentElement + .appendChild( table ) + .appendChild( tr ) + .appendChild( trChild ); + + trStyle = window.getComputedStyle( tr ); + reliableTrDimensionsVal = ( parseInt( trStyle.height, 10 ) + + parseInt( trStyle.borderTopWidth, 10 ) + + parseInt( trStyle.borderBottomWidth, 10 ) ) === tr.offsetHeight; + + documentElement.removeChild( table ); + } + return reliableTrDimensionsVal; + } + } ); +} )(); + + +function curCSS( elem, name, computed ) { + var width, minWidth, maxWidth, ret, + + // Support: Firefox 51+ + // Retrieving style before computed somehow + // fixes an issue with getting wrong values + // on detached elements + style = elem.style; + + computed = computed || getStyles( elem ); + + // getPropertyValue is needed for: + // .css('filter') (IE 9 only, #12537) + // .css('--customProperty) (#3144) + if ( computed ) { + ret = computed.getPropertyValue( name ) || computed[ name ]; + + if ( ret === "" && !isAttached( elem ) ) { + ret = jQuery.style( elem, name ); + } + + // A tribute to the "awesome hack by Dean Edwards" + // Android Browser returns percentage for some values, + // but width seems to be reliably pixels. + // This is against the CSSOM draft spec: + // https://drafts.csswg.org/cssom/#resolved-values + if ( !support.pixelBoxStyles() && rnumnonpx.test( ret ) && rboxStyle.test( name ) ) { + + // Remember the original values + width = style.width; + minWidth = style.minWidth; + maxWidth = style.maxWidth; + + // Put in the new values to get a computed value out + style.minWidth = style.maxWidth = style.width = ret; + ret = computed.width; + + // Revert the changed values + style.width = width; + style.minWidth = minWidth; + style.maxWidth = maxWidth; + } + } + + return ret !== undefined ? + + // Support: IE <=9 - 11 only + // IE returns zIndex value as an integer. + ret + "" : + ret; +} + + +function addGetHookIf( conditionFn, hookFn ) { + + // Define the hook, we'll check on the first run if it's really needed. + return { + get: function() { + if ( conditionFn() ) { + + // Hook not needed (or it's not possible to use it due + // to missing dependency), remove it. + delete this.get; + return; + } + + // Hook needed; redefine it so that the support test is not executed again. + return ( this.get = hookFn ).apply( this, arguments ); + } + }; +} + + +var cssPrefixes = [ "Webkit", "Moz", "ms" ], + emptyStyle = document.createElement( "div" ).style, + vendorProps = {}; + +// Return a vendor-prefixed property or undefined +function vendorPropName( name ) { + + // Check for vendor prefixed names + var capName = name[ 0 ].toUpperCase() + name.slice( 1 ), + i = cssPrefixes.length; + + while ( i-- ) { + name = cssPrefixes[ i ] + capName; + if ( name in emptyStyle ) { + return name; + } + } +} + +// Return a potentially-mapped jQuery.cssProps or vendor prefixed property +function finalPropName( name ) { + var final = jQuery.cssProps[ name ] || vendorProps[ name ]; + + if ( final ) { + return final; + } + if ( name in emptyStyle ) { + return name; + } + return vendorProps[ name ] = vendorPropName( name ) || name; +} + + +var + + // Swappable if display is none or starts with table + // except "table", "table-cell", or "table-caption" + // See here for display values: https://developer.mozilla.org/en-US/docs/CSS/display + rdisplayswap = /^(none|table(?!-c[ea]).+)/, + rcustomProp = /^--/, + cssShow = { position: "absolute", visibility: "hidden", display: "block" }, + cssNormalTransform = { + letterSpacing: "0", + fontWeight: "400" + }; + +function setPositiveNumber( _elem, value, subtract ) { + + // Any relative (+/-) values have already been + // normalized at this point + var matches = rcssNum.exec( value ); + return matches ? + + // Guard against undefined "subtract", e.g., when used as in cssHooks + Math.max( 0, matches[ 2 ] - ( subtract || 0 ) ) + ( matches[ 3 ] || "px" ) : + value; +} + +function boxModelAdjustment( elem, dimension, box, isBorderBox, styles, computedVal ) { + var i = dimension === "width" ? 1 : 0, + extra = 0, + delta = 0; + + // Adjustment may not be necessary + if ( box === ( isBorderBox ? "border" : "content" ) ) { + return 0; + } + + for ( ; i < 4; i += 2 ) { + + // Both box models exclude margin + if ( box === "margin" ) { + delta += jQuery.css( elem, box + cssExpand[ i ], true, styles ); + } + + // If we get here with a content-box, we're seeking "padding" or "border" or "margin" + if ( !isBorderBox ) { + + // Add padding + delta += jQuery.css( elem, "padding" + cssExpand[ i ], true, styles ); + + // For "border" or "margin", add border + if ( box !== "padding" ) { + delta += jQuery.css( elem, "border" + cssExpand[ i ] + "Width", true, styles ); + + // But still keep track of it otherwise + } else { + extra += jQuery.css( elem, "border" + cssExpand[ i ] + "Width", true, styles ); + } + + // If we get here with a border-box (content + padding + border), we're seeking "content" or + // "padding" or "margin" + } else { + + // For "content", subtract padding + if ( box === "content" ) { + delta -= jQuery.css( elem, "padding" + cssExpand[ i ], true, styles ); + } + + // For "content" or "padding", subtract border + if ( box !== "margin" ) { + delta -= jQuery.css( elem, "border" + cssExpand[ i ] + "Width", true, styles ); + } + } + } + + // Account for positive content-box scroll gutter when requested by providing computedVal + if ( !isBorderBox && computedVal >= 0 ) { + + // offsetWidth/offsetHeight is a rounded sum of content, padding, scroll gutter, and border + // Assuming integer scroll gutter, subtract the rest and round down + delta += Math.max( 0, Math.ceil( + elem[ "offset" + dimension[ 0 ].toUpperCase() + dimension.slice( 1 ) ] - + computedVal - + delta - + extra - + 0.5 + + // If offsetWidth/offsetHeight is unknown, then we can't determine content-box scroll gutter + // Use an explicit zero to avoid NaN (gh-3964) + ) ) || 0; + } + + return delta; +} + +function getWidthOrHeight( elem, dimension, extra ) { + + // Start with computed style + var styles = getStyles( elem ), + + // To avoid forcing a reflow, only fetch boxSizing if we need it (gh-4322). + // Fake content-box until we know it's needed to know the true value. + boxSizingNeeded = !support.boxSizingReliable() || extra, + isBorderBox = boxSizingNeeded && + jQuery.css( elem, "boxSizing", false, styles ) === "border-box", + valueIsBorderBox = isBorderBox, + + val = curCSS( elem, dimension, styles ), + offsetProp = "offset" + dimension[ 0 ].toUpperCase() + dimension.slice( 1 ); + + // Support: Firefox <=54 + // Return a confounding non-pixel value or feign ignorance, as appropriate. + if ( rnumnonpx.test( val ) ) { + if ( !extra ) { + return val; + } + val = "auto"; + } + + + // Support: IE 9 - 11 only + // Use offsetWidth/offsetHeight for when box sizing is unreliable. + // In those cases, the computed value can be trusted to be border-box. + if ( ( !support.boxSizingReliable() && isBorderBox || + + // Support: IE 10 - 11+, Edge 15 - 18+ + // IE/Edge misreport `getComputedStyle` of table rows with width/height + // set in CSS while `offset*` properties report correct values. + // Interestingly, in some cases IE 9 doesn't suffer from this issue. + !support.reliableTrDimensions() && nodeName( elem, "tr" ) || + + // Fall back to offsetWidth/offsetHeight when value is "auto" + // This happens for inline elements with no explicit setting (gh-3571) + val === "auto" || + + // Support: Android <=4.1 - 4.3 only + // Also use offsetWidth/offsetHeight for misreported inline dimensions (gh-3602) + !parseFloat( val ) && jQuery.css( elem, "display", false, styles ) === "inline" ) && + + // Make sure the element is visible & connected + elem.getClientRects().length ) { + + isBorderBox = jQuery.css( elem, "boxSizing", false, styles ) === "border-box"; + + // Where available, offsetWidth/offsetHeight approximate border box dimensions. + // Where not available (e.g., SVG), assume unreliable box-sizing and interpret the + // retrieved value as a content box dimension. + valueIsBorderBox = offsetProp in elem; + if ( valueIsBorderBox ) { + val = elem[ offsetProp ]; + } + } + + // Normalize "" and auto + val = parseFloat( val ) || 0; + + // Adjust for the element's box model + return ( val + + boxModelAdjustment( + elem, + dimension, + extra || ( isBorderBox ? "border" : "content" ), + valueIsBorderBox, + styles, + + // Provide the current computed size to request scroll gutter calculation (gh-3589) + val + ) + ) + "px"; +} + +jQuery.extend( { + + // Add in style property hooks for overriding the default + // behavior of getting and setting a style property + cssHooks: { + opacity: { + get: function( elem, computed ) { + if ( computed ) { + + // We should always get a number back from opacity + var ret = curCSS( elem, "opacity" ); + return ret === "" ? "1" : ret; + } + } + } + }, + + // Don't automatically add "px" to these possibly-unitless properties + cssNumber: { + "animationIterationCount": true, + "columnCount": true, + "fillOpacity": true, + "flexGrow": true, + "flexShrink": true, + "fontWeight": true, + "gridArea": true, + "gridColumn": true, + "gridColumnEnd": true, + "gridColumnStart": true, + "gridRow": true, + "gridRowEnd": true, + "gridRowStart": true, + "lineHeight": true, + "opacity": true, + "order": true, + "orphans": true, + "widows": true, + "zIndex": true, + "zoom": true + }, + + // Add in properties whose names you wish to fix before + // setting or getting the value + cssProps: {}, + + // Get and set the style property on a DOM Node + style: function( elem, name, value, extra ) { + + // Don't set styles on text and comment nodes + if ( !elem || elem.nodeType === 3 || elem.nodeType === 8 || !elem.style ) { + return; + } + + // Make sure that we're working with the right name + var ret, type, hooks, + origName = camelCase( name ), + isCustomProp = rcustomProp.test( name ), + style = elem.style; + + // Make sure that we're working with the right name. We don't + // want to query the value if it is a CSS custom property + // since they are user-defined. + if ( !isCustomProp ) { + name = finalPropName( origName ); + } + + // Gets hook for the prefixed version, then unprefixed version + hooks = jQuery.cssHooks[ name ] || jQuery.cssHooks[ origName ]; + + // Check if we're setting a value + if ( value !== undefined ) { + type = typeof value; + + // Convert "+=" or "-=" to relative numbers (#7345) + if ( type === "string" && ( ret = rcssNum.exec( value ) ) && ret[ 1 ] ) { + value = adjustCSS( elem, name, ret ); + + // Fixes bug #9237 + type = "number"; + } + + // Make sure that null and NaN values aren't set (#7116) + if ( value == null || value !== value ) { + return; + } + + // If a number was passed in, add the unit (except for certain CSS properties) + // The isCustomProp check can be removed in jQuery 4.0 when we only auto-append + // "px" to a few hardcoded values. + if ( type === "number" && !isCustomProp ) { + value += ret && ret[ 3 ] || ( jQuery.cssNumber[ origName ] ? "" : "px" ); + } + + // background-* props affect original clone's values + if ( !support.clearCloneStyle && value === "" && name.indexOf( "background" ) === 0 ) { + style[ name ] = "inherit"; + } + + // If a hook was provided, use that value, otherwise just set the specified value + if ( !hooks || !( "set" in hooks ) || + ( value = hooks.set( elem, value, extra ) ) !== undefined ) { + + if ( isCustomProp ) { + style.setProperty( name, value ); + } else { + style[ name ] = value; + } + } + + } else { + + // If a hook was provided get the non-computed value from there + if ( hooks && "get" in hooks && + ( ret = hooks.get( elem, false, extra ) ) !== undefined ) { + + return ret; + } + + // Otherwise just get the value from the style object + return style[ name ]; + } + }, + + css: function( elem, name, extra, styles ) { + var val, num, hooks, + origName = camelCase( name ), + isCustomProp = rcustomProp.test( name ); + + // Make sure that we're working with the right name. We don't + // want to modify the value if it is a CSS custom property + // since they are user-defined. + if ( !isCustomProp ) { + name = finalPropName( origName ); + } + + // Try prefixed name followed by the unprefixed name + hooks = jQuery.cssHooks[ name ] || jQuery.cssHooks[ origName ]; + + // If a hook was provided get the computed value from there + if ( hooks && "get" in hooks ) { + val = hooks.get( elem, true, extra ); + } + + // Otherwise, if a way to get the computed value exists, use that + if ( val === undefined ) { + val = curCSS( elem, name, styles ); + } + + // Convert "normal" to computed value + if ( val === "normal" && name in cssNormalTransform ) { + val = cssNormalTransform[ name ]; + } + + // Make numeric if forced or a qualifier was provided and val looks numeric + if ( extra === "" || extra ) { + num = parseFloat( val ); + return extra === true || isFinite( num ) ? num || 0 : val; + } + + return val; + } +} ); + +jQuery.each( [ "height", "width" ], function( _i, dimension ) { + jQuery.cssHooks[ dimension ] = { + get: function( elem, computed, extra ) { + if ( computed ) { + + // Certain elements can have dimension info if we invisibly show them + // but it must have a current display style that would benefit + return rdisplayswap.test( jQuery.css( elem, "display" ) ) && + + // Support: Safari 8+ + // Table columns in Safari have non-zero offsetWidth & zero + // getBoundingClientRect().width unless display is changed. + // Support: IE <=11 only + // Running getBoundingClientRect on a disconnected node + // in IE throws an error. + ( !elem.getClientRects().length || !elem.getBoundingClientRect().width ) ? + swap( elem, cssShow, function() { + return getWidthOrHeight( elem, dimension, extra ); + } ) : + getWidthOrHeight( elem, dimension, extra ); + } + }, + + set: function( elem, value, extra ) { + var matches, + styles = getStyles( elem ), + + // Only read styles.position if the test has a chance to fail + // to avoid forcing a reflow. + scrollboxSizeBuggy = !support.scrollboxSize() && + styles.position === "absolute", + + // To avoid forcing a reflow, only fetch boxSizing if we need it (gh-3991) + boxSizingNeeded = scrollboxSizeBuggy || extra, + isBorderBox = boxSizingNeeded && + jQuery.css( elem, "boxSizing", false, styles ) === "border-box", + subtract = extra ? + boxModelAdjustment( + elem, + dimension, + extra, + isBorderBox, + styles + ) : + 0; + + // Account for unreliable border-box dimensions by comparing offset* to computed and + // faking a content-box to get border and padding (gh-3699) + if ( isBorderBox && scrollboxSizeBuggy ) { + subtract -= Math.ceil( + elem[ "offset" + dimension[ 0 ].toUpperCase() + dimension.slice( 1 ) ] - + parseFloat( styles[ dimension ] ) - + boxModelAdjustment( elem, dimension, "border", false, styles ) - + 0.5 + ); + } + + // Convert to pixels if value adjustment is needed + if ( subtract && ( matches = rcssNum.exec( value ) ) && + ( matches[ 3 ] || "px" ) !== "px" ) { + + elem.style[ dimension ] = value; + value = jQuery.css( elem, dimension ); + } + + return setPositiveNumber( elem, value, subtract ); + } + }; +} ); + +jQuery.cssHooks.marginLeft = addGetHookIf( support.reliableMarginLeft, + function( elem, computed ) { + if ( computed ) { + return ( parseFloat( curCSS( elem, "marginLeft" ) ) || + elem.getBoundingClientRect().left - + swap( elem, { marginLeft: 0 }, function() { + return elem.getBoundingClientRect().left; + } ) + ) + "px"; + } + } +); + +// These hooks are used by animate to expand properties +jQuery.each( { + margin: "", + padding: "", + border: "Width" +}, function( prefix, suffix ) { + jQuery.cssHooks[ prefix + suffix ] = { + expand: function( value ) { + var i = 0, + expanded = {}, + + // Assumes a single number if not a string + parts = typeof value === "string" ? value.split( " " ) : [ value ]; + + for ( ; i < 4; i++ ) { + expanded[ prefix + cssExpand[ i ] + suffix ] = + parts[ i ] || parts[ i - 2 ] || parts[ 0 ]; + } + + return expanded; + } + }; + + if ( prefix !== "margin" ) { + jQuery.cssHooks[ prefix + suffix ].set = setPositiveNumber; + } +} ); + +jQuery.fn.extend( { + css: function( name, value ) { + return access( this, function( elem, name, value ) { + var styles, len, + map = {}, + i = 0; + + if ( Array.isArray( name ) ) { + styles = getStyles( elem ); + len = name.length; + + for ( ; i < len; i++ ) { + map[ name[ i ] ] = jQuery.css( elem, name[ i ], false, styles ); + } + + return map; + } + + return value !== undefined ? + jQuery.style( elem, name, value ) : + jQuery.css( elem, name ); + }, name, value, arguments.length > 1 ); + } +} ); + + +function Tween( elem, options, prop, end, easing ) { + return new Tween.prototype.init( elem, options, prop, end, easing ); +} +jQuery.Tween = Tween; + +Tween.prototype = { + constructor: Tween, + init: function( elem, options, prop, end, easing, unit ) { + this.elem = elem; + this.prop = prop; + this.easing = easing || jQuery.easing._default; + this.options = options; + this.start = this.now = this.cur(); + this.end = end; + this.unit = unit || ( jQuery.cssNumber[ prop ] ? "" : "px" ); + }, + cur: function() { + var hooks = Tween.propHooks[ this.prop ]; + + return hooks && hooks.get ? + hooks.get( this ) : + Tween.propHooks._default.get( this ); + }, + run: function( percent ) { + var eased, + hooks = Tween.propHooks[ this.prop ]; + + if ( this.options.duration ) { + this.pos = eased = jQuery.easing[ this.easing ]( + percent, this.options.duration * percent, 0, 1, this.options.duration + ); + } else { + this.pos = eased = percent; + } + this.now = ( this.end - this.start ) * eased + this.start; + + if ( this.options.step ) { + this.options.step.call( this.elem, this.now, this ); + } + + if ( hooks && hooks.set ) { + hooks.set( this ); + } else { + Tween.propHooks._default.set( this ); + } + return this; + } +}; + +Tween.prototype.init.prototype = Tween.prototype; + +Tween.propHooks = { + _default: { + get: function( tween ) { + var result; + + // Use a property on the element directly when it is not a DOM element, + // or when there is no matching style property that exists. + if ( tween.elem.nodeType !== 1 || + tween.elem[ tween.prop ] != null && tween.elem.style[ tween.prop ] == null ) { + return tween.elem[ tween.prop ]; + } + + // Passing an empty string as a 3rd parameter to .css will automatically + // attempt a parseFloat and fallback to a string if the parse fails. + // Simple values such as "10px" are parsed to Float; + // complex values such as "rotate(1rad)" are returned as-is. + result = jQuery.css( tween.elem, tween.prop, "" ); + + // Empty strings, null, undefined and "auto" are converted to 0. + return !result || result === "auto" ? 0 : result; + }, + set: function( tween ) { + + // Use step hook for back compat. + // Use cssHook if its there. + // Use .style if available and use plain properties where available. + if ( jQuery.fx.step[ tween.prop ] ) { + jQuery.fx.step[ tween.prop ]( tween ); + } else if ( tween.elem.nodeType === 1 && ( + jQuery.cssHooks[ tween.prop ] || + tween.elem.style[ finalPropName( tween.prop ) ] != null ) ) { + jQuery.style( tween.elem, tween.prop, tween.now + tween.unit ); + } else { + tween.elem[ tween.prop ] = tween.now; + } + } + } +}; + +// Support: IE <=9 only +// Panic based approach to setting things on disconnected nodes +Tween.propHooks.scrollTop = Tween.propHooks.scrollLeft = { + set: function( tween ) { + if ( tween.elem.nodeType && tween.elem.parentNode ) { + tween.elem[ tween.prop ] = tween.now; + } + } +}; + +jQuery.easing = { + linear: function( p ) { + return p; + }, + swing: function( p ) { + return 0.5 - Math.cos( p * Math.PI ) / 2; + }, + _default: "swing" +}; + +jQuery.fx = Tween.prototype.init; + +// Back compat <1.8 extension point +jQuery.fx.step = {}; + + + + +var + fxNow, inProgress, + rfxtypes = /^(?:toggle|show|hide)$/, + rrun = /queueHooks$/; + +function schedule() { + if ( inProgress ) { + if ( document.hidden === false && window.requestAnimationFrame ) { + window.requestAnimationFrame( schedule ); + } else { + window.setTimeout( schedule, jQuery.fx.interval ); + } + + jQuery.fx.tick(); + } +} + +// Animations created synchronously will run synchronously +function createFxNow() { + window.setTimeout( function() { + fxNow = undefined; + } ); + return ( fxNow = Date.now() ); +} + +// Generate parameters to create a standard animation +function genFx( type, includeWidth ) { + var which, + i = 0, + attrs = { height: type }; + + // If we include width, step value is 1 to do all cssExpand values, + // otherwise step value is 2 to skip over Left and Right + includeWidth = includeWidth ? 1 : 0; + for ( ; i < 4; i += 2 - includeWidth ) { + which = cssExpand[ i ]; + attrs[ "margin" + which ] = attrs[ "padding" + which ] = type; + } + + if ( includeWidth ) { + attrs.opacity = attrs.width = type; + } + + return attrs; +} + +function createTween( value, prop, animation ) { + var tween, + collection = ( Animation.tweeners[ prop ] || [] ).concat( Animation.tweeners[ "*" ] ), + index = 0, + length = collection.length; + for ( ; index < length; index++ ) { + if ( ( tween = collection[ index ].call( animation, prop, value ) ) ) { + + // We're done with this property + return tween; + } + } +} + +function defaultPrefilter( elem, props, opts ) { + var prop, value, toggle, hooks, oldfire, propTween, restoreDisplay, display, + isBox = "width" in props || "height" in props, + anim = this, + orig = {}, + style = elem.style, + hidden = elem.nodeType && isHiddenWithinTree( elem ), + dataShow = dataPriv.get( elem, "fxshow" ); + + // Queue-skipping animations hijack the fx hooks + if ( !opts.queue ) { + hooks = jQuery._queueHooks( elem, "fx" ); + if ( hooks.unqueued == null ) { + hooks.unqueued = 0; + oldfire = hooks.empty.fire; + hooks.empty.fire = function() { + if ( !hooks.unqueued ) { + oldfire(); + } + }; + } + hooks.unqueued++; + + anim.always( function() { + + // Ensure the complete handler is called before this completes + anim.always( function() { + hooks.unqueued--; + if ( !jQuery.queue( elem, "fx" ).length ) { + hooks.empty.fire(); + } + } ); + } ); + } + + // Detect show/hide animations + for ( prop in props ) { + value = props[ prop ]; + if ( rfxtypes.test( value ) ) { + delete props[ prop ]; + toggle = toggle || value === "toggle"; + if ( value === ( hidden ? "hide" : "show" ) ) { + + // Pretend to be hidden if this is a "show" and + // there is still data from a stopped show/hide + if ( value === "show" && dataShow && dataShow[ prop ] !== undefined ) { + hidden = true; + + // Ignore all other no-op show/hide data + } else { + continue; + } + } + orig[ prop ] = dataShow && dataShow[ prop ] || jQuery.style( elem, prop ); + } + } + + // Bail out if this is a no-op like .hide().hide() + propTween = !jQuery.isEmptyObject( props ); + if ( !propTween && jQuery.isEmptyObject( orig ) ) { + return; + } + + // Restrict "overflow" and "display" styles during box animations + if ( isBox && elem.nodeType === 1 ) { + + // Support: IE <=9 - 11, Edge 12 - 15 + // Record all 3 overflow attributes because IE does not infer the shorthand + // from identically-valued overflowX and overflowY and Edge just mirrors + // the overflowX value there. + opts.overflow = [ style.overflow, style.overflowX, style.overflowY ]; + + // Identify a display type, preferring old show/hide data over the CSS cascade + restoreDisplay = dataShow && dataShow.display; + if ( restoreDisplay == null ) { + restoreDisplay = dataPriv.get( elem, "display" ); + } + display = jQuery.css( elem, "display" ); + if ( display === "none" ) { + if ( restoreDisplay ) { + display = restoreDisplay; + } else { + + // Get nonempty value(s) by temporarily forcing visibility + showHide( [ elem ], true ); + restoreDisplay = elem.style.display || restoreDisplay; + display = jQuery.css( elem, "display" ); + showHide( [ elem ] ); + } + } + + // Animate inline elements as inline-block + if ( display === "inline" || display === "inline-block" && restoreDisplay != null ) { + if ( jQuery.css( elem, "float" ) === "none" ) { + + // Restore the original display value at the end of pure show/hide animations + if ( !propTween ) { + anim.done( function() { + style.display = restoreDisplay; + } ); + if ( restoreDisplay == null ) { + display = style.display; + restoreDisplay = display === "none" ? "" : display; + } + } + style.display = "inline-block"; + } + } + } + + if ( opts.overflow ) { + style.overflow = "hidden"; + anim.always( function() { + style.overflow = opts.overflow[ 0 ]; + style.overflowX = opts.overflow[ 1 ]; + style.overflowY = opts.overflow[ 2 ]; + } ); + } + + // Implement show/hide animations + propTween = false; + for ( prop in orig ) { + + // General show/hide setup for this element animation + if ( !propTween ) { + if ( dataShow ) { + if ( "hidden" in dataShow ) { + hidden = dataShow.hidden; + } + } else { + dataShow = dataPriv.access( elem, "fxshow", { display: restoreDisplay } ); + } + + // Store hidden/visible for toggle so `.stop().toggle()` "reverses" + if ( toggle ) { + dataShow.hidden = !hidden; + } + + // Show elements before animating them + if ( hidden ) { + showHide( [ elem ], true ); + } + + /* eslint-disable no-loop-func */ + + anim.done( function() { + + /* eslint-enable no-loop-func */ + + // The final step of a "hide" animation is actually hiding the element + if ( !hidden ) { + showHide( [ elem ] ); + } + dataPriv.remove( elem, "fxshow" ); + for ( prop in orig ) { + jQuery.style( elem, prop, orig[ prop ] ); + } + } ); + } + + // Per-property setup + propTween = createTween( hidden ? dataShow[ prop ] : 0, prop, anim ); + if ( !( prop in dataShow ) ) { + dataShow[ prop ] = propTween.start; + if ( hidden ) { + propTween.end = propTween.start; + propTween.start = 0; + } + } + } +} + +function propFilter( props, specialEasing ) { + var index, name, easing, value, hooks; + + // camelCase, specialEasing and expand cssHook pass + for ( index in props ) { + name = camelCase( index ); + easing = specialEasing[ name ]; + value = props[ index ]; + if ( Array.isArray( value ) ) { + easing = value[ 1 ]; + value = props[ index ] = value[ 0 ]; + } + + if ( index !== name ) { + props[ name ] = value; + delete props[ index ]; + } + + hooks = jQuery.cssHooks[ name ]; + if ( hooks && "expand" in hooks ) { + value = hooks.expand( value ); + delete props[ name ]; + + // Not quite $.extend, this won't overwrite existing keys. + // Reusing 'index' because we have the correct "name" + for ( index in value ) { + if ( !( index in props ) ) { + props[ index ] = value[ index ]; + specialEasing[ index ] = easing; + } + } + } else { + specialEasing[ name ] = easing; + } + } +} + +function Animation( elem, properties, options ) { + var result, + stopped, + index = 0, + length = Animation.prefilters.length, + deferred = jQuery.Deferred().always( function() { + + // Don't match elem in the :animated selector + delete tick.elem; + } ), + tick = function() { + if ( stopped ) { + return false; + } + var currentTime = fxNow || createFxNow(), + remaining = Math.max( 0, animation.startTime + animation.duration - currentTime ), + + // Support: Android 2.3 only + // Archaic crash bug won't allow us to use `1 - ( 0.5 || 0 )` (#12497) + temp = remaining / animation.duration || 0, + percent = 1 - temp, + index = 0, + length = animation.tweens.length; + + for ( ; index < length; index++ ) { + animation.tweens[ index ].run( percent ); + } + + deferred.notifyWith( elem, [ animation, percent, remaining ] ); + + // If there's more to do, yield + if ( percent < 1 && length ) { + return remaining; + } + + // If this was an empty animation, synthesize a final progress notification + if ( !length ) { + deferred.notifyWith( elem, [ animation, 1, 0 ] ); + } + + // Resolve the animation and report its conclusion + deferred.resolveWith( elem, [ animation ] ); + return false; + }, + animation = deferred.promise( { + elem: elem, + props: jQuery.extend( {}, properties ), + opts: jQuery.extend( true, { + specialEasing: {}, + easing: jQuery.easing._default + }, options ), + originalProperties: properties, + originalOptions: options, + startTime: fxNow || createFxNow(), + duration: options.duration, + tweens: [], + createTween: function( prop, end ) { + var tween = jQuery.Tween( elem, animation.opts, prop, end, + animation.opts.specialEasing[ prop ] || animation.opts.easing ); + animation.tweens.push( tween ); + return tween; + }, + stop: function( gotoEnd ) { + var index = 0, + + // If we are going to the end, we want to run all the tweens + // otherwise we skip this part + length = gotoEnd ? animation.tweens.length : 0; + if ( stopped ) { + return this; + } + stopped = true; + for ( ; index < length; index++ ) { + animation.tweens[ index ].run( 1 ); + } + + // Resolve when we played the last frame; otherwise, reject + if ( gotoEnd ) { + deferred.notifyWith( elem, [ animation, 1, 0 ] ); + deferred.resolveWith( elem, [ animation, gotoEnd ] ); + } else { + deferred.rejectWith( elem, [ animation, gotoEnd ] ); + } + return this; + } + } ), + props = animation.props; + + propFilter( props, animation.opts.specialEasing ); + + for ( ; index < length; index++ ) { + result = Animation.prefilters[ index ].call( animation, elem, props, animation.opts ); + if ( result ) { + if ( isFunction( result.stop ) ) { + jQuery._queueHooks( animation.elem, animation.opts.queue ).stop = + result.stop.bind( result ); + } + return result; + } + } + + jQuery.map( props, createTween, animation ); + + if ( isFunction( animation.opts.start ) ) { + animation.opts.start.call( elem, animation ); + } + + // Attach callbacks from options + animation + .progress( animation.opts.progress ) + .done( animation.opts.done, animation.opts.complete ) + .fail( animation.opts.fail ) + .always( animation.opts.always ); + + jQuery.fx.timer( + jQuery.extend( tick, { + elem: elem, + anim: animation, + queue: animation.opts.queue + } ) + ); + + return animation; +} + +jQuery.Animation = jQuery.extend( Animation, { + + tweeners: { + "*": [ function( prop, value ) { + var tween = this.createTween( prop, value ); + adjustCSS( tween.elem, prop, rcssNum.exec( value ), tween ); + return tween; + } ] + }, + + tweener: function( props, callback ) { + if ( isFunction( props ) ) { + callback = props; + props = [ "*" ]; + } else { + props = props.match( rnothtmlwhite ); + } + + var prop, + index = 0, + length = props.length; + + for ( ; index < length; index++ ) { + prop = props[ index ]; + Animation.tweeners[ prop ] = Animation.tweeners[ prop ] || []; + Animation.tweeners[ prop ].unshift( callback ); + } + }, + + prefilters: [ defaultPrefilter ], + + prefilter: function( callback, prepend ) { + if ( prepend ) { + Animation.prefilters.unshift( callback ); + } else { + Animation.prefilters.push( callback ); + } + } +} ); + +jQuery.speed = function( speed, easing, fn ) { + var opt = speed && typeof speed === "object" ? jQuery.extend( {}, speed ) : { + complete: fn || !fn && easing || + isFunction( speed ) && speed, + duration: speed, + easing: fn && easing || easing && !isFunction( easing ) && easing + }; + + // Go to the end state if fx are off + if ( jQuery.fx.off ) { + opt.duration = 0; + + } else { + if ( typeof opt.duration !== "number" ) { + if ( opt.duration in jQuery.fx.speeds ) { + opt.duration = jQuery.fx.speeds[ opt.duration ]; + + } else { + opt.duration = jQuery.fx.speeds._default; + } + } + } + + // Normalize opt.queue - true/undefined/null -> "fx" + if ( opt.queue == null || opt.queue === true ) { + opt.queue = "fx"; + } + + // Queueing + opt.old = opt.complete; + + opt.complete = function() { + if ( isFunction( opt.old ) ) { + opt.old.call( this ); + } + + if ( opt.queue ) { + jQuery.dequeue( this, opt.queue ); + } + }; + + return opt; +}; + +jQuery.fn.extend( { + fadeTo: function( speed, to, easing, callback ) { + + // Show any hidden elements after setting opacity to 0 + return this.filter( isHiddenWithinTree ).css( "opacity", 0 ).show() + + // Animate to the value specified + .end().animate( { opacity: to }, speed, easing, callback ); + }, + animate: function( prop, speed, easing, callback ) { + var empty = jQuery.isEmptyObject( prop ), + optall = jQuery.speed( speed, easing, callback ), + doAnimation = function() { + + // Operate on a copy of prop so per-property easing won't be lost + var anim = Animation( this, jQuery.extend( {}, prop ), optall ); + + // Empty animations, or finishing resolves immediately + if ( empty || dataPriv.get( this, "finish" ) ) { + anim.stop( true ); + } + }; + + doAnimation.finish = doAnimation; + + return empty || optall.queue === false ? + this.each( doAnimation ) : + this.queue( optall.queue, doAnimation ); + }, + stop: function( type, clearQueue, gotoEnd ) { + var stopQueue = function( hooks ) { + var stop = hooks.stop; + delete hooks.stop; + stop( gotoEnd ); + }; + + if ( typeof type !== "string" ) { + gotoEnd = clearQueue; + clearQueue = type; + type = undefined; + } + if ( clearQueue ) { + this.queue( type || "fx", [] ); + } + + return this.each( function() { + var dequeue = true, + index = type != null && type + "queueHooks", + timers = jQuery.timers, + data = dataPriv.get( this ); + + if ( index ) { + if ( data[ index ] && data[ index ].stop ) { + stopQueue( data[ index ] ); + } + } else { + for ( index in data ) { + if ( data[ index ] && data[ index ].stop && rrun.test( index ) ) { + stopQueue( data[ index ] ); + } + } + } + + for ( index = timers.length; index--; ) { + if ( timers[ index ].elem === this && + ( type == null || timers[ index ].queue === type ) ) { + + timers[ index ].anim.stop( gotoEnd ); + dequeue = false; + timers.splice( index, 1 ); + } + } + + // Start the next in the queue if the last step wasn't forced. + // Timers currently will call their complete callbacks, which + // will dequeue but only if they were gotoEnd. + if ( dequeue || !gotoEnd ) { + jQuery.dequeue( this, type ); + } + } ); + }, + finish: function( type ) { + if ( type !== false ) { + type = type || "fx"; + } + return this.each( function() { + var index, + data = dataPriv.get( this ), + queue = data[ type + "queue" ], + hooks = data[ type + "queueHooks" ], + timers = jQuery.timers, + length = queue ? queue.length : 0; + + // Enable finishing flag on private data + data.finish = true; + + // Empty the queue first + jQuery.queue( this, type, [] ); + + if ( hooks && hooks.stop ) { + hooks.stop.call( this, true ); + } + + // Look for any active animations, and finish them + for ( index = timers.length; index--; ) { + if ( timers[ index ].elem === this && timers[ index ].queue === type ) { + timers[ index ].anim.stop( true ); + timers.splice( index, 1 ); + } + } + + // Look for any animations in the old queue and finish them + for ( index = 0; index < length; index++ ) { + if ( queue[ index ] && queue[ index ].finish ) { + queue[ index ].finish.call( this ); + } + } + + // Turn off finishing flag + delete data.finish; + } ); + } +} ); + +jQuery.each( [ "toggle", "show", "hide" ], function( _i, name ) { + var cssFn = jQuery.fn[ name ]; + jQuery.fn[ name ] = function( speed, easing, callback ) { + return speed == null || typeof speed === "boolean" ? + cssFn.apply( this, arguments ) : + this.animate( genFx( name, true ), speed, easing, callback ); + }; +} ); + +// Generate shortcuts for custom animations +jQuery.each( { + slideDown: genFx( "show" ), + slideUp: genFx( "hide" ), + slideToggle: genFx( "toggle" ), + fadeIn: { opacity: "show" }, + fadeOut: { opacity: "hide" }, + fadeToggle: { opacity: "toggle" } +}, function( name, props ) { + jQuery.fn[ name ] = function( speed, easing, callback ) { + return this.animate( props, speed, easing, callback ); + }; +} ); + +jQuery.timers = []; +jQuery.fx.tick = function() { + var timer, + i = 0, + timers = jQuery.timers; + + fxNow = Date.now(); + + for ( ; i < timers.length; i++ ) { + timer = timers[ i ]; + + // Run the timer and safely remove it when done (allowing for external removal) + if ( !timer() && timers[ i ] === timer ) { + timers.splice( i--, 1 ); + } + } + + if ( !timers.length ) { + jQuery.fx.stop(); + } + fxNow = undefined; +}; + +jQuery.fx.timer = function( timer ) { + jQuery.timers.push( timer ); + jQuery.fx.start(); +}; + +jQuery.fx.interval = 13; +jQuery.fx.start = function() { + if ( inProgress ) { + return; + } + + inProgress = true; + schedule(); +}; + +jQuery.fx.stop = function() { + inProgress = null; +}; + +jQuery.fx.speeds = { + slow: 600, + fast: 200, + + // Default speed + _default: 400 +}; + + +// Based off of the plugin by Clint Helfers, with permission. +// https://web.archive.org/web/20100324014747/http://blindsignals.com/index.php/2009/07/jquery-delay/ +jQuery.fn.delay = function( time, type ) { + time = jQuery.fx ? jQuery.fx.speeds[ time ] || time : time; + type = type || "fx"; + + return this.queue( type, function( next, hooks ) { + var timeout = window.setTimeout( next, time ); + hooks.stop = function() { + window.clearTimeout( timeout ); + }; + } ); +}; + + +( function() { + var input = document.createElement( "input" ), + select = document.createElement( "select" ), + opt = select.appendChild( document.createElement( "option" ) ); + + input.type = "checkbox"; + + // Support: Android <=4.3 only + // Default value for a checkbox should be "on" + support.checkOn = input.value !== ""; + + // Support: IE <=11 only + // Must access selectedIndex to make default options select + support.optSelected = opt.selected; + + // Support: IE <=11 only + // An input loses its value after becoming a radio + input = document.createElement( "input" ); + input.value = "t"; + input.type = "radio"; + support.radioValue = input.value === "t"; +} )(); + + +var boolHook, + attrHandle = jQuery.expr.attrHandle; + +jQuery.fn.extend( { + attr: function( name, value ) { + return access( this, jQuery.attr, name, value, arguments.length > 1 ); + }, + + removeAttr: function( name ) { + return this.each( function() { + jQuery.removeAttr( this, name ); + } ); + } +} ); + +jQuery.extend( { + attr: function( elem, name, value ) { + var ret, hooks, + nType = elem.nodeType; + + // Don't get/set attributes on text, comment and attribute nodes + if ( nType === 3 || nType === 8 || nType === 2 ) { + return; + } + + // Fallback to prop when attributes are not supported + if ( typeof elem.getAttribute === "undefined" ) { + return jQuery.prop( elem, name, value ); + } + + // Attribute hooks are determined by the lowercase version + // Grab necessary hook if one is defined + if ( nType !== 1 || !jQuery.isXMLDoc( elem ) ) { + hooks = jQuery.attrHooks[ name.toLowerCase() ] || + ( jQuery.expr.match.bool.test( name ) ? boolHook : undefined ); + } + + if ( value !== undefined ) { + if ( value === null ) { + jQuery.removeAttr( elem, name ); + return; + } + + if ( hooks && "set" in hooks && + ( ret = hooks.set( elem, value, name ) ) !== undefined ) { + return ret; + } + + elem.setAttribute( name, value + "" ); + return value; + } + + if ( hooks && "get" in hooks && ( ret = hooks.get( elem, name ) ) !== null ) { + return ret; + } + + ret = jQuery.find.attr( elem, name ); + + // Non-existent attributes return null, we normalize to undefined + return ret == null ? undefined : ret; + }, + + attrHooks: { + type: { + set: function( elem, value ) { + if ( !support.radioValue && value === "radio" && + nodeName( elem, "input" ) ) { + var val = elem.value; + elem.setAttribute( "type", value ); + if ( val ) { + elem.value = val; + } + return value; + } + } + } + }, + + removeAttr: function( elem, value ) { + var name, + i = 0, + + // Attribute names can contain non-HTML whitespace characters + // https://html.spec.whatwg.org/multipage/syntax.html#attributes-2 + attrNames = value && value.match( rnothtmlwhite ); + + if ( attrNames && elem.nodeType === 1 ) { + while ( ( name = attrNames[ i++ ] ) ) { + elem.removeAttribute( name ); + } + } + } +} ); + +// Hooks for boolean attributes +boolHook = { + set: function( elem, value, name ) { + if ( value === false ) { + + // Remove boolean attributes when set to false + jQuery.removeAttr( elem, name ); + } else { + elem.setAttribute( name, name ); + } + return name; + } +}; + +jQuery.each( jQuery.expr.match.bool.source.match( /\w+/g ), function( _i, name ) { + var getter = attrHandle[ name ] || jQuery.find.attr; + + attrHandle[ name ] = function( elem, name, isXML ) { + var ret, handle, + lowercaseName = name.toLowerCase(); + + if ( !isXML ) { + + // Avoid an infinite loop by temporarily removing this function from the getter + handle = attrHandle[ lowercaseName ]; + attrHandle[ lowercaseName ] = ret; + ret = getter( elem, name, isXML ) != null ? + lowercaseName : + null; + attrHandle[ lowercaseName ] = handle; + } + return ret; + }; +} ); + + + + +var rfocusable = /^(?:input|select|textarea|button)$/i, + rclickable = /^(?:a|area)$/i; + +jQuery.fn.extend( { + prop: function( name, value ) { + return access( this, jQuery.prop, name, value, arguments.length > 1 ); + }, + + removeProp: function( name ) { + return this.each( function() { + delete this[ jQuery.propFix[ name ] || name ]; + } ); + } +} ); + +jQuery.extend( { + prop: function( elem, name, value ) { + var ret, hooks, + nType = elem.nodeType; + + // Don't get/set properties on text, comment and attribute nodes + if ( nType === 3 || nType === 8 || nType === 2 ) { + return; + } + + if ( nType !== 1 || !jQuery.isXMLDoc( elem ) ) { + + // Fix name and attach hooks + name = jQuery.propFix[ name ] || name; + hooks = jQuery.propHooks[ name ]; + } + + if ( value !== undefined ) { + if ( hooks && "set" in hooks && + ( ret = hooks.set( elem, value, name ) ) !== undefined ) { + return ret; + } + + return ( elem[ name ] = value ); + } + + if ( hooks && "get" in hooks && ( ret = hooks.get( elem, name ) ) !== null ) { + return ret; + } + + return elem[ name ]; + }, + + propHooks: { + tabIndex: { + get: function( elem ) { + + // Support: IE <=9 - 11 only + // elem.tabIndex doesn't always return the + // correct value when it hasn't been explicitly set + // https://web.archive.org/web/20141116233347/http://fluidproject.org/blog/2008/01/09/getting-setting-and-removing-tabindex-values-with-javascript/ + // Use proper attribute retrieval(#12072) + var tabindex = jQuery.find.attr( elem, "tabindex" ); + + if ( tabindex ) { + return parseInt( tabindex, 10 ); + } + + if ( + rfocusable.test( elem.nodeName ) || + rclickable.test( elem.nodeName ) && + elem.href + ) { + return 0; + } + + return -1; + } + } + }, + + propFix: { + "for": "htmlFor", + "class": "className" + } +} ); + +// Support: IE <=11 only +// Accessing the selectedIndex property +// forces the browser to respect setting selected +// on the option +// The getter ensures a default option is selected +// when in an optgroup +// eslint rule "no-unused-expressions" is disabled for this code +// since it considers such accessions noop +if ( !support.optSelected ) { + jQuery.propHooks.selected = { + get: function( elem ) { + + /* eslint no-unused-expressions: "off" */ + + var parent = elem.parentNode; + if ( parent && parent.parentNode ) { + parent.parentNode.selectedIndex; + } + return null; + }, + set: function( elem ) { + + /* eslint no-unused-expressions: "off" */ + + var parent = elem.parentNode; + if ( parent ) { + parent.selectedIndex; + + if ( parent.parentNode ) { + parent.parentNode.selectedIndex; + } + } + } + }; +} + +jQuery.each( [ + "tabIndex", + "readOnly", + "maxLength", + "cellSpacing", + "cellPadding", + "rowSpan", + "colSpan", + "useMap", + "frameBorder", + "contentEditable" +], function() { + jQuery.propFix[ this.toLowerCase() ] = this; +} ); + + + + + // Strip and collapse whitespace according to HTML spec + // https://infra.spec.whatwg.org/#strip-and-collapse-ascii-whitespace + function stripAndCollapse( value ) { + var tokens = value.match( rnothtmlwhite ) || []; + return tokens.join( " " ); + } + + +function getClass( elem ) { + return elem.getAttribute && elem.getAttribute( "class" ) || ""; +} + +function classesToArray( value ) { + if ( Array.isArray( value ) ) { + return value; + } + if ( typeof value === "string" ) { + return value.match( rnothtmlwhite ) || []; + } + return []; +} + +jQuery.fn.extend( { + addClass: function( value ) { + var classes, elem, cur, curValue, clazz, j, finalValue, + i = 0; + + if ( isFunction( value ) ) { + return this.each( function( j ) { + jQuery( this ).addClass( value.call( this, j, getClass( this ) ) ); + } ); + } + + classes = classesToArray( value ); + + if ( classes.length ) { + while ( ( elem = this[ i++ ] ) ) { + curValue = getClass( elem ); + cur = elem.nodeType === 1 && ( " " + stripAndCollapse( curValue ) + " " ); + + if ( cur ) { + j = 0; + while ( ( clazz = classes[ j++ ] ) ) { + if ( cur.indexOf( " " + clazz + " " ) < 0 ) { + cur += clazz + " "; + } + } + + // Only assign if different to avoid unneeded rendering. + finalValue = stripAndCollapse( cur ); + if ( curValue !== finalValue ) { + elem.setAttribute( "class", finalValue ); + } + } + } + } + + return this; + }, + + removeClass: function( value ) { + var classes, elem, cur, curValue, clazz, j, finalValue, + i = 0; + + if ( isFunction( value ) ) { + return this.each( function( j ) { + jQuery( this ).removeClass( value.call( this, j, getClass( this ) ) ); + } ); + } + + if ( !arguments.length ) { + return this.attr( "class", "" ); + } + + classes = classesToArray( value ); + + if ( classes.length ) { + while ( ( elem = this[ i++ ] ) ) { + curValue = getClass( elem ); + + // This expression is here for better compressibility (see addClass) + cur = elem.nodeType === 1 && ( " " + stripAndCollapse( curValue ) + " " ); + + if ( cur ) { + j = 0; + while ( ( clazz = classes[ j++ ] ) ) { + + // Remove *all* instances + while ( cur.indexOf( " " + clazz + " " ) > -1 ) { + cur = cur.replace( " " + clazz + " ", " " ); + } + } + + // Only assign if different to avoid unneeded rendering. + finalValue = stripAndCollapse( cur ); + if ( curValue !== finalValue ) { + elem.setAttribute( "class", finalValue ); + } + } + } + } + + return this; + }, + + toggleClass: function( value, stateVal ) { + var type = typeof value, + isValidValue = type === "string" || Array.isArray( value ); + + if ( typeof stateVal === "boolean" && isValidValue ) { + return stateVal ? this.addClass( value ) : this.removeClass( value ); + } + + if ( isFunction( value ) ) { + return this.each( function( i ) { + jQuery( this ).toggleClass( + value.call( this, i, getClass( this ), stateVal ), + stateVal + ); + } ); + } + + return this.each( function() { + var className, i, self, classNames; + + if ( isValidValue ) { + + // Toggle individual class names + i = 0; + self = jQuery( this ); + classNames = classesToArray( value ); + + while ( ( className = classNames[ i++ ] ) ) { + + // Check each className given, space separated list + if ( self.hasClass( className ) ) { + self.removeClass( className ); + } else { + self.addClass( className ); + } + } + + // Toggle whole class name + } else if ( value === undefined || type === "boolean" ) { + className = getClass( this ); + if ( className ) { + + // Store className if set + dataPriv.set( this, "__className__", className ); + } + + // If the element has a class name or if we're passed `false`, + // then remove the whole classname (if there was one, the above saved it). + // Otherwise bring back whatever was previously saved (if anything), + // falling back to the empty string if nothing was stored. + if ( this.setAttribute ) { + this.setAttribute( "class", + className || value === false ? + "" : + dataPriv.get( this, "__className__" ) || "" + ); + } + } + } ); + }, + + hasClass: function( selector ) { + var className, elem, + i = 0; + + className = " " + selector + " "; + while ( ( elem = this[ i++ ] ) ) { + if ( elem.nodeType === 1 && + ( " " + stripAndCollapse( getClass( elem ) ) + " " ).indexOf( className ) > -1 ) { + return true; + } + } + + return false; + } +} ); + + + + +var rreturn = /\r/g; + +jQuery.fn.extend( { + val: function( value ) { + var hooks, ret, valueIsFunction, + elem = this[ 0 ]; + + if ( !arguments.length ) { + if ( elem ) { + hooks = jQuery.valHooks[ elem.type ] || + jQuery.valHooks[ elem.nodeName.toLowerCase() ]; + + if ( hooks && + "get" in hooks && + ( ret = hooks.get( elem, "value" ) ) !== undefined + ) { + return ret; + } + + ret = elem.value; + + // Handle most common string cases + if ( typeof ret === "string" ) { + return ret.replace( rreturn, "" ); + } + + // Handle cases where value is null/undef or number + return ret == null ? "" : ret; + } + + return; + } + + valueIsFunction = isFunction( value ); + + return this.each( function( i ) { + var val; + + if ( this.nodeType !== 1 ) { + return; + } + + if ( valueIsFunction ) { + val = value.call( this, i, jQuery( this ).val() ); + } else { + val = value; + } + + // Treat null/undefined as ""; convert numbers to string + if ( val == null ) { + val = ""; + + } else if ( typeof val === "number" ) { + val += ""; + + } else if ( Array.isArray( val ) ) { + val = jQuery.map( val, function( value ) { + return value == null ? "" : value + ""; + } ); + } + + hooks = jQuery.valHooks[ this.type ] || jQuery.valHooks[ this.nodeName.toLowerCase() ]; + + // If set returns undefined, fall back to normal setting + if ( !hooks || !( "set" in hooks ) || hooks.set( this, val, "value" ) === undefined ) { + this.value = val; + } + } ); + } +} ); + +jQuery.extend( { + valHooks: { + option: { + get: function( elem ) { + + var val = jQuery.find.attr( elem, "value" ); + return val != null ? + val : + + // Support: IE <=10 - 11 only + // option.text throws exceptions (#14686, #14858) + // Strip and collapse whitespace + // https://html.spec.whatwg.org/#strip-and-collapse-whitespace + stripAndCollapse( jQuery.text( elem ) ); + } + }, + select: { + get: function( elem ) { + var value, option, i, + options = elem.options, + index = elem.selectedIndex, + one = elem.type === "select-one", + values = one ? null : [], + max = one ? index + 1 : options.length; + + if ( index < 0 ) { + i = max; + + } else { + i = one ? index : 0; + } + + // Loop through all the selected options + for ( ; i < max; i++ ) { + option = options[ i ]; + + // Support: IE <=9 only + // IE8-9 doesn't update selected after form reset (#2551) + if ( ( option.selected || i === index ) && + + // Don't return options that are disabled or in a disabled optgroup + !option.disabled && + ( !option.parentNode.disabled || + !nodeName( option.parentNode, "optgroup" ) ) ) { + + // Get the specific value for the option + value = jQuery( option ).val(); + + // We don't need an array for one selects + if ( one ) { + return value; + } + + // Multi-Selects return an array + values.push( value ); + } + } + + return values; + }, + + set: function( elem, value ) { + var optionSet, option, + options = elem.options, + values = jQuery.makeArray( value ), + i = options.length; + + while ( i-- ) { + option = options[ i ]; + + /* eslint-disable no-cond-assign */ + + if ( option.selected = + jQuery.inArray( jQuery.valHooks.option.get( option ), values ) > -1 + ) { + optionSet = true; + } + + /* eslint-enable no-cond-assign */ + } + + // Force browsers to behave consistently when non-matching value is set + if ( !optionSet ) { + elem.selectedIndex = -1; + } + return values; + } + } + } +} ); + +// Radios and checkboxes getter/setter +jQuery.each( [ "radio", "checkbox" ], function() { + jQuery.valHooks[ this ] = { + set: function( elem, value ) { + if ( Array.isArray( value ) ) { + return ( elem.checked = jQuery.inArray( jQuery( elem ).val(), value ) > -1 ); + } + } + }; + if ( !support.checkOn ) { + jQuery.valHooks[ this ].get = function( elem ) { + return elem.getAttribute( "value" ) === null ? "on" : elem.value; + }; + } +} ); + + + + +// Return jQuery for attributes-only inclusion + + +support.focusin = "onfocusin" in window; + + +var rfocusMorph = /^(?:focusinfocus|focusoutblur)$/, + stopPropagationCallback = function( e ) { + e.stopPropagation(); + }; + +jQuery.extend( jQuery.event, { + + trigger: function( event, data, elem, onlyHandlers ) { + + var i, cur, tmp, bubbleType, ontype, handle, special, lastElement, + eventPath = [ elem || document ], + type = hasOwn.call( event, "type" ) ? event.type : event, + namespaces = hasOwn.call( event, "namespace" ) ? event.namespace.split( "." ) : []; + + cur = lastElement = tmp = elem = elem || document; + + // Don't do events on text and comment nodes + if ( elem.nodeType === 3 || elem.nodeType === 8 ) { + return; + } + + // focus/blur morphs to focusin/out; ensure we're not firing them right now + if ( rfocusMorph.test( type + jQuery.event.triggered ) ) { + return; + } + + if ( type.indexOf( "." ) > -1 ) { + + // Namespaced trigger; create a regexp to match event type in handle() + namespaces = type.split( "." ); + type = namespaces.shift(); + namespaces.sort(); + } + ontype = type.indexOf( ":" ) < 0 && "on" + type; + + // Caller can pass in a jQuery.Event object, Object, or just an event type string + event = event[ jQuery.expando ] ? + event : + new jQuery.Event( type, typeof event === "object" && event ); + + // Trigger bitmask: & 1 for native handlers; & 2 for jQuery (always true) + event.isTrigger = onlyHandlers ? 2 : 3; + event.namespace = namespaces.join( "." ); + event.rnamespace = event.namespace ? + new RegExp( "(^|\\.)" + namespaces.join( "\\.(?:.*\\.|)" ) + "(\\.|$)" ) : + null; + + // Clean up the event in case it is being reused + event.result = undefined; + if ( !event.target ) { + event.target = elem; + } + + // Clone any incoming data and prepend the event, creating the handler arg list + data = data == null ? + [ event ] : + jQuery.makeArray( data, [ event ] ); + + // Allow special events to draw outside the lines + special = jQuery.event.special[ type ] || {}; + if ( !onlyHandlers && special.trigger && special.trigger.apply( elem, data ) === false ) { + return; + } + + // Determine event propagation path in advance, per W3C events spec (#9951) + // Bubble up to document, then to window; watch for a global ownerDocument var (#9724) + if ( !onlyHandlers && !special.noBubble && !isWindow( elem ) ) { + + bubbleType = special.delegateType || type; + if ( !rfocusMorph.test( bubbleType + type ) ) { + cur = cur.parentNode; + } + for ( ; cur; cur = cur.parentNode ) { + eventPath.push( cur ); + tmp = cur; + } + + // Only add window if we got to document (e.g., not plain obj or detached DOM) + if ( tmp === ( elem.ownerDocument || document ) ) { + eventPath.push( tmp.defaultView || tmp.parentWindow || window ); + } + } + + // Fire handlers on the event path + i = 0; + while ( ( cur = eventPath[ i++ ] ) && !event.isPropagationStopped() ) { + lastElement = cur; + event.type = i > 1 ? + bubbleType : + special.bindType || type; + + // jQuery handler + handle = ( dataPriv.get( cur, "events" ) || Object.create( null ) )[ event.type ] && + dataPriv.get( cur, "handle" ); + if ( handle ) { + handle.apply( cur, data ); + } + + // Native handler + handle = ontype && cur[ ontype ]; + if ( handle && handle.apply && acceptData( cur ) ) { + event.result = handle.apply( cur, data ); + if ( event.result === false ) { + event.preventDefault(); + } + } + } + event.type = type; + + // If nobody prevented the default action, do it now + if ( !onlyHandlers && !event.isDefaultPrevented() ) { + + if ( ( !special._default || + special._default.apply( eventPath.pop(), data ) === false ) && + acceptData( elem ) ) { + + // Call a native DOM method on the target with the same name as the event. + // Don't do default actions on window, that's where global variables be (#6170) + if ( ontype && isFunction( elem[ type ] ) && !isWindow( elem ) ) { + + // Don't re-trigger an onFOO event when we call its FOO() method + tmp = elem[ ontype ]; + + if ( tmp ) { + elem[ ontype ] = null; + } + + // Prevent re-triggering of the same event, since we already bubbled it above + jQuery.event.triggered = type; + + if ( event.isPropagationStopped() ) { + lastElement.addEventListener( type, stopPropagationCallback ); + } + + elem[ type ](); + + if ( event.isPropagationStopped() ) { + lastElement.removeEventListener( type, stopPropagationCallback ); + } + + jQuery.event.triggered = undefined; + + if ( tmp ) { + elem[ ontype ] = tmp; + } + } + } + } + + return event.result; + }, + + // Piggyback on a donor event to simulate a different one + // Used only for `focus(in | out)` events + simulate: function( type, elem, event ) { + var e = jQuery.extend( + new jQuery.Event(), + event, + { + type: type, + isSimulated: true + } + ); + + jQuery.event.trigger( e, null, elem ); + } + +} ); + +jQuery.fn.extend( { + + trigger: function( type, data ) { + return this.each( function() { + jQuery.event.trigger( type, data, this ); + } ); + }, + triggerHandler: function( type, data ) { + var elem = this[ 0 ]; + if ( elem ) { + return jQuery.event.trigger( type, data, elem, true ); + } + } +} ); + + +// Support: Firefox <=44 +// Firefox doesn't have focus(in | out) events +// Related ticket - https://bugzilla.mozilla.org/show_bug.cgi?id=687787 +// +// Support: Chrome <=48 - 49, Safari <=9.0 - 9.1 +// focus(in | out) events fire after focus & blur events, +// which is spec violation - http://www.w3.org/TR/DOM-Level-3-Events/#events-focusevent-event-order +// Related ticket - https://bugs.chromium.org/p/chromium/issues/detail?id=449857 +if ( !support.focusin ) { + jQuery.each( { focus: "focusin", blur: "focusout" }, function( orig, fix ) { + + // Attach a single capturing handler on the document while someone wants focusin/focusout + var handler = function( event ) { + jQuery.event.simulate( fix, event.target, jQuery.event.fix( event ) ); + }; + + jQuery.event.special[ fix ] = { + setup: function() { + + // Handle: regular nodes (via `this.ownerDocument`), window + // (via `this.document`) & document (via `this`). + var doc = this.ownerDocument || this.document || this, + attaches = dataPriv.access( doc, fix ); + + if ( !attaches ) { + doc.addEventListener( orig, handler, true ); + } + dataPriv.access( doc, fix, ( attaches || 0 ) + 1 ); + }, + teardown: function() { + var doc = this.ownerDocument || this.document || this, + attaches = dataPriv.access( doc, fix ) - 1; + + if ( !attaches ) { + doc.removeEventListener( orig, handler, true ); + dataPriv.remove( doc, fix ); + + } else { + dataPriv.access( doc, fix, attaches ); + } + } + }; + } ); +} +var location = window.location; + +var nonce = { guid: Date.now() }; + +var rquery = ( /\?/ ); + + + +// Cross-browser xml parsing +jQuery.parseXML = function( data ) { + var xml, parserErrorElem; + if ( !data || typeof data !== "string" ) { + return null; + } + + // Support: IE 9 - 11 only + // IE throws on parseFromString with invalid input. + try { + xml = ( new window.DOMParser() ).parseFromString( data, "text/xml" ); + } catch ( e ) {} + + parserErrorElem = xml && xml.getElementsByTagName( "parsererror" )[ 0 ]; + if ( !xml || parserErrorElem ) { + jQuery.error( "Invalid XML: " + ( + parserErrorElem ? + jQuery.map( parserErrorElem.childNodes, function( el ) { + return el.textContent; + } ).join( "\n" ) : + data + ) ); + } + return xml; +}; + + +var + rbracket = /\[\]$/, + rCRLF = /\r?\n/g, + rsubmitterTypes = /^(?:submit|button|image|reset|file)$/i, + rsubmittable = /^(?:input|select|textarea|keygen)/i; + +function buildParams( prefix, obj, traditional, add ) { + var name; + + if ( Array.isArray( obj ) ) { + + // Serialize array item. + jQuery.each( obj, function( i, v ) { + if ( traditional || rbracket.test( prefix ) ) { + + // Treat each array item as a scalar. + add( prefix, v ); + + } else { + + // Item is non-scalar (array or object), encode its numeric index. + buildParams( + prefix + "[" + ( typeof v === "object" && v != null ? i : "" ) + "]", + v, + traditional, + add + ); + } + } ); + + } else if ( !traditional && toType( obj ) === "object" ) { + + // Serialize object item. + for ( name in obj ) { + buildParams( prefix + "[" + name + "]", obj[ name ], traditional, add ); + } + + } else { + + // Serialize scalar item. + add( prefix, obj ); + } +} + +// Serialize an array of form elements or a set of +// key/values into a query string +jQuery.param = function( a, traditional ) { + var prefix, + s = [], + add = function( key, valueOrFunction ) { + + // If value is a function, invoke it and use its return value + var value = isFunction( valueOrFunction ) ? + valueOrFunction() : + valueOrFunction; + + s[ s.length ] = encodeURIComponent( key ) + "=" + + encodeURIComponent( value == null ? "" : value ); + }; + + if ( a == null ) { + return ""; + } + + // If an array was passed in, assume that it is an array of form elements. + if ( Array.isArray( a ) || ( a.jquery && !jQuery.isPlainObject( a ) ) ) { + + // Serialize the form elements + jQuery.each( a, function() { + add( this.name, this.value ); + } ); + + } else { + + // If traditional, encode the "old" way (the way 1.3.2 or older + // did it), otherwise encode params recursively. + for ( prefix in a ) { + buildParams( prefix, a[ prefix ], traditional, add ); + } + } + + // Return the resulting serialization + return s.join( "&" ); +}; + +jQuery.fn.extend( { + serialize: function() { + return jQuery.param( this.serializeArray() ); + }, + serializeArray: function() { + return this.map( function() { + + // Can add propHook for "elements" to filter or add form elements + var elements = jQuery.prop( this, "elements" ); + return elements ? jQuery.makeArray( elements ) : this; + } ).filter( function() { + var type = this.type; + + // Use .is( ":disabled" ) so that fieldset[disabled] works + return this.name && !jQuery( this ).is( ":disabled" ) && + rsubmittable.test( this.nodeName ) && !rsubmitterTypes.test( type ) && + ( this.checked || !rcheckableType.test( type ) ); + } ).map( function( _i, elem ) { + var val = jQuery( this ).val(); + + if ( val == null ) { + return null; + } + + if ( Array.isArray( val ) ) { + return jQuery.map( val, function( val ) { + return { name: elem.name, value: val.replace( rCRLF, "\r\n" ) }; + } ); + } + + return { name: elem.name, value: val.replace( rCRLF, "\r\n" ) }; + } ).get(); + } +} ); + + +var + r20 = /%20/g, + rhash = /#.*$/, + rantiCache = /([?&])_=[^&]*/, + rheaders = /^(.*?):[ \t]*([^\r\n]*)$/mg, + + // #7653, #8125, #8152: local protocol detection + rlocalProtocol = /^(?:about|app|app-storage|.+-extension|file|res|widget):$/, + rnoContent = /^(?:GET|HEAD)$/, + rprotocol = /^\/\//, + + /* Prefilters + * 1) They are useful to introduce custom dataTypes (see ajax/jsonp.js for an example) + * 2) These are called: + * - BEFORE asking for a transport + * - AFTER param serialization (s.data is a string if s.processData is true) + * 3) key is the dataType + * 4) the catchall symbol "*" can be used + * 5) execution will start with transport dataType and THEN continue down to "*" if needed + */ + prefilters = {}, + + /* Transports bindings + * 1) key is the dataType + * 2) the catchall symbol "*" can be used + * 3) selection will start with transport dataType and THEN go to "*" if needed + */ + transports = {}, + + // Avoid comment-prolog char sequence (#10098); must appease lint and evade compression + allTypes = "*/".concat( "*" ), + + // Anchor tag for parsing the document origin + originAnchor = document.createElement( "a" ); + +originAnchor.href = location.href; + +// Base "constructor" for jQuery.ajaxPrefilter and jQuery.ajaxTransport +function addToPrefiltersOrTransports( structure ) { + + // dataTypeExpression is optional and defaults to "*" + return function( dataTypeExpression, func ) { + + if ( typeof dataTypeExpression !== "string" ) { + func = dataTypeExpression; + dataTypeExpression = "*"; + } + + var dataType, + i = 0, + dataTypes = dataTypeExpression.toLowerCase().match( rnothtmlwhite ) || []; + + if ( isFunction( func ) ) { + + // For each dataType in the dataTypeExpression + while ( ( dataType = dataTypes[ i++ ] ) ) { + + // Prepend if requested + if ( dataType[ 0 ] === "+" ) { + dataType = dataType.slice( 1 ) || "*"; + ( structure[ dataType ] = structure[ dataType ] || [] ).unshift( func ); + + // Otherwise append + } else { + ( structure[ dataType ] = structure[ dataType ] || [] ).push( func ); + } + } + } + }; +} + +// Base inspection function for prefilters and transports +function inspectPrefiltersOrTransports( structure, options, originalOptions, jqXHR ) { + + var inspected = {}, + seekingTransport = ( structure === transports ); + + function inspect( dataType ) { + var selected; + inspected[ dataType ] = true; + jQuery.each( structure[ dataType ] || [], function( _, prefilterOrFactory ) { + var dataTypeOrTransport = prefilterOrFactory( options, originalOptions, jqXHR ); + if ( typeof dataTypeOrTransport === "string" && + !seekingTransport && !inspected[ dataTypeOrTransport ] ) { + + options.dataTypes.unshift( dataTypeOrTransport ); + inspect( dataTypeOrTransport ); + return false; + } else if ( seekingTransport ) { + return !( selected = dataTypeOrTransport ); + } + } ); + return selected; + } + + return inspect( options.dataTypes[ 0 ] ) || !inspected[ "*" ] && inspect( "*" ); +} + +// A special extend for ajax options +// that takes "flat" options (not to be deep extended) +// Fixes #9887 +function ajaxExtend( target, src ) { + var key, deep, + flatOptions = jQuery.ajaxSettings.flatOptions || {}; + + for ( key in src ) { + if ( src[ key ] !== undefined ) { + ( flatOptions[ key ] ? target : ( deep || ( deep = {} ) ) )[ key ] = src[ key ]; + } + } + if ( deep ) { + jQuery.extend( true, target, deep ); + } + + return target; +} + +/* Handles responses to an ajax request: + * - finds the right dataType (mediates between content-type and expected dataType) + * - returns the corresponding response + */ +function ajaxHandleResponses( s, jqXHR, responses ) { + + var ct, type, finalDataType, firstDataType, + contents = s.contents, + dataTypes = s.dataTypes; + + // Remove auto dataType and get content-type in the process + while ( dataTypes[ 0 ] === "*" ) { + dataTypes.shift(); + if ( ct === undefined ) { + ct = s.mimeType || jqXHR.getResponseHeader( "Content-Type" ); + } + } + + // Check if we're dealing with a known content-type + if ( ct ) { + for ( type in contents ) { + if ( contents[ type ] && contents[ type ].test( ct ) ) { + dataTypes.unshift( type ); + break; + } + } + } + + // Check to see if we have a response for the expected dataType + if ( dataTypes[ 0 ] in responses ) { + finalDataType = dataTypes[ 0 ]; + } else { + + // Try convertible dataTypes + for ( type in responses ) { + if ( !dataTypes[ 0 ] || s.converters[ type + " " + dataTypes[ 0 ] ] ) { + finalDataType = type; + break; + } + if ( !firstDataType ) { + firstDataType = type; + } + } + + // Or just use first one + finalDataType = finalDataType || firstDataType; + } + + // If we found a dataType + // We add the dataType to the list if needed + // and return the corresponding response + if ( finalDataType ) { + if ( finalDataType !== dataTypes[ 0 ] ) { + dataTypes.unshift( finalDataType ); + } + return responses[ finalDataType ]; + } +} + +/* Chain conversions given the request and the original response + * Also sets the responseXXX fields on the jqXHR instance + */ +function ajaxConvert( s, response, jqXHR, isSuccess ) { + var conv2, current, conv, tmp, prev, + converters = {}, + + // Work with a copy of dataTypes in case we need to modify it for conversion + dataTypes = s.dataTypes.slice(); + + // Create converters map with lowercased keys + if ( dataTypes[ 1 ] ) { + for ( conv in s.converters ) { + converters[ conv.toLowerCase() ] = s.converters[ conv ]; + } + } + + current = dataTypes.shift(); + + // Convert to each sequential dataType + while ( current ) { + + if ( s.responseFields[ current ] ) { + jqXHR[ s.responseFields[ current ] ] = response; + } + + // Apply the dataFilter if provided + if ( !prev && isSuccess && s.dataFilter ) { + response = s.dataFilter( response, s.dataType ); + } + + prev = current; + current = dataTypes.shift(); + + if ( current ) { + + // There's only work to do if current dataType is non-auto + if ( current === "*" ) { + + current = prev; + + // Convert response if prev dataType is non-auto and differs from current + } else if ( prev !== "*" && prev !== current ) { + + // Seek a direct converter + conv = converters[ prev + " " + current ] || converters[ "* " + current ]; + + // If none found, seek a pair + if ( !conv ) { + for ( conv2 in converters ) { + + // If conv2 outputs current + tmp = conv2.split( " " ); + if ( tmp[ 1 ] === current ) { + + // If prev can be converted to accepted input + conv = converters[ prev + " " + tmp[ 0 ] ] || + converters[ "* " + tmp[ 0 ] ]; + if ( conv ) { + + // Condense equivalence converters + if ( conv === true ) { + conv = converters[ conv2 ]; + + // Otherwise, insert the intermediate dataType + } else if ( converters[ conv2 ] !== true ) { + current = tmp[ 0 ]; + dataTypes.unshift( tmp[ 1 ] ); + } + break; + } + } + } + } + + // Apply converter (if not an equivalence) + if ( conv !== true ) { + + // Unless errors are allowed to bubble, catch and return them + if ( conv && s.throws ) { + response = conv( response ); + } else { + try { + response = conv( response ); + } catch ( e ) { + return { + state: "parsererror", + error: conv ? e : "No conversion from " + prev + " to " + current + }; + } + } + } + } + } + } + + return { state: "success", data: response }; +} + +jQuery.extend( { + + // Counter for holding the number of active queries + active: 0, + + // Last-Modified header cache for next request + lastModified: {}, + etag: {}, + + ajaxSettings: { + url: location.href, + type: "GET", + isLocal: rlocalProtocol.test( location.protocol ), + global: true, + processData: true, + async: true, + contentType: "application/x-www-form-urlencoded; charset=UTF-8", + + /* + timeout: 0, + data: null, + dataType: null, + username: null, + password: null, + cache: null, + throws: false, + traditional: false, + headers: {}, + */ + + accepts: { + "*": allTypes, + text: "text/plain", + html: "text/html", + xml: "application/xml, text/xml", + json: "application/json, text/javascript" + }, + + contents: { + xml: /\bxml\b/, + html: /\bhtml/, + json: /\bjson\b/ + }, + + responseFields: { + xml: "responseXML", + text: "responseText", + json: "responseJSON" + }, + + // Data converters + // Keys separate source (or catchall "*") and destination types with a single space + converters: { + + // Convert anything to text + "* text": String, + + // Text to html (true = no transformation) + "text html": true, + + // Evaluate text as a json expression + "text json": JSON.parse, + + // Parse text as xml + "text xml": jQuery.parseXML + }, + + // For options that shouldn't be deep extended: + // you can add your own custom options here if + // and when you create one that shouldn't be + // deep extended (see ajaxExtend) + flatOptions: { + url: true, + context: true + } + }, + + // Creates a full fledged settings object into target + // with both ajaxSettings and settings fields. + // If target is omitted, writes into ajaxSettings. + ajaxSetup: function( target, settings ) { + return settings ? + + // Building a settings object + ajaxExtend( ajaxExtend( target, jQuery.ajaxSettings ), settings ) : + + // Extending ajaxSettings + ajaxExtend( jQuery.ajaxSettings, target ); + }, + + ajaxPrefilter: addToPrefiltersOrTransports( prefilters ), + ajaxTransport: addToPrefiltersOrTransports( transports ), + + // Main method + ajax: function( url, options ) { + + // If url is an object, simulate pre-1.5 signature + if ( typeof url === "object" ) { + options = url; + url = undefined; + } + + // Force options to be an object + options = options || {}; + + var transport, + + // URL without anti-cache param + cacheURL, + + // Response headers + responseHeadersString, + responseHeaders, + + // timeout handle + timeoutTimer, + + // Url cleanup var + urlAnchor, + + // Request state (becomes false upon send and true upon completion) + completed, + + // To know if global events are to be dispatched + fireGlobals, + + // Loop variable + i, + + // uncached part of the url + uncached, + + // Create the final options object + s = jQuery.ajaxSetup( {}, options ), + + // Callbacks context + callbackContext = s.context || s, + + // Context for global events is callbackContext if it is a DOM node or jQuery collection + globalEventContext = s.context && + ( callbackContext.nodeType || callbackContext.jquery ) ? + jQuery( callbackContext ) : + jQuery.event, + + // Deferreds + deferred = jQuery.Deferred(), + completeDeferred = jQuery.Callbacks( "once memory" ), + + // Status-dependent callbacks + statusCode = s.statusCode || {}, + + // Headers (they are sent all at once) + requestHeaders = {}, + requestHeadersNames = {}, + + // Default abort message + strAbort = "canceled", + + // Fake xhr + jqXHR = { + readyState: 0, + + // Builds headers hashtable if needed + getResponseHeader: function( key ) { + var match; + if ( completed ) { + if ( !responseHeaders ) { + responseHeaders = {}; + while ( ( match = rheaders.exec( responseHeadersString ) ) ) { + responseHeaders[ match[ 1 ].toLowerCase() + " " ] = + ( responseHeaders[ match[ 1 ].toLowerCase() + " " ] || [] ) + .concat( match[ 2 ] ); + } + } + match = responseHeaders[ key.toLowerCase() + " " ]; + } + return match == null ? null : match.join( ", " ); + }, + + // Raw string + getAllResponseHeaders: function() { + return completed ? responseHeadersString : null; + }, + + // Caches the header + setRequestHeader: function( name, value ) { + if ( completed == null ) { + name = requestHeadersNames[ name.toLowerCase() ] = + requestHeadersNames[ name.toLowerCase() ] || name; + requestHeaders[ name ] = value; + } + return this; + }, + + // Overrides response content-type header + overrideMimeType: function( type ) { + if ( completed == null ) { + s.mimeType = type; + } + return this; + }, + + // Status-dependent callbacks + statusCode: function( map ) { + var code; + if ( map ) { + if ( completed ) { + + // Execute the appropriate callbacks + jqXHR.always( map[ jqXHR.status ] ); + } else { + + // Lazy-add the new callbacks in a way that preserves old ones + for ( code in map ) { + statusCode[ code ] = [ statusCode[ code ], map[ code ] ]; + } + } + } + return this; + }, + + // Cancel the request + abort: function( statusText ) { + var finalText = statusText || strAbort; + if ( transport ) { + transport.abort( finalText ); + } + done( 0, finalText ); + return this; + } + }; + + // Attach deferreds + deferred.promise( jqXHR ); + + // Add protocol if not provided (prefilters might expect it) + // Handle falsy url in the settings object (#10093: consistency with old signature) + // We also use the url parameter if available + s.url = ( ( url || s.url || location.href ) + "" ) + .replace( rprotocol, location.protocol + "//" ); + + // Alias method option to type as per ticket #12004 + s.type = options.method || options.type || s.method || s.type; + + // Extract dataTypes list + s.dataTypes = ( s.dataType || "*" ).toLowerCase().match( rnothtmlwhite ) || [ "" ]; + + // A cross-domain request is in order when the origin doesn't match the current origin. + if ( s.crossDomain == null ) { + urlAnchor = document.createElement( "a" ); + + // Support: IE <=8 - 11, Edge 12 - 15 + // IE throws exception on accessing the href property if url is malformed, + // e.g. http://example.com:80x/ + try { + urlAnchor.href = s.url; + + // Support: IE <=8 - 11 only + // Anchor's host property isn't correctly set when s.url is relative + urlAnchor.href = urlAnchor.href; + s.crossDomain = originAnchor.protocol + "//" + originAnchor.host !== + urlAnchor.protocol + "//" + urlAnchor.host; + } catch ( e ) { + + // If there is an error parsing the URL, assume it is crossDomain, + // it can be rejected by the transport if it is invalid + s.crossDomain = true; + } + } + + // Convert data if not already a string + if ( s.data && s.processData && typeof s.data !== "string" ) { + s.data = jQuery.param( s.data, s.traditional ); + } + + // Apply prefilters + inspectPrefiltersOrTransports( prefilters, s, options, jqXHR ); + + // If request was aborted inside a prefilter, stop there + if ( completed ) { + return jqXHR; + } + + // We can fire global events as of now if asked to + // Don't fire events if jQuery.event is undefined in an AMD-usage scenario (#15118) + fireGlobals = jQuery.event && s.global; + + // Watch for a new set of requests + if ( fireGlobals && jQuery.active++ === 0 ) { + jQuery.event.trigger( "ajaxStart" ); + } + + // Uppercase the type + s.type = s.type.toUpperCase(); + + // Determine if request has content + s.hasContent = !rnoContent.test( s.type ); + + // Save the URL in case we're toying with the If-Modified-Since + // and/or If-None-Match header later on + // Remove hash to simplify url manipulation + cacheURL = s.url.replace( rhash, "" ); + + // More options handling for requests with no content + if ( !s.hasContent ) { + + // Remember the hash so we can put it back + uncached = s.url.slice( cacheURL.length ); + + // If data is available and should be processed, append data to url + if ( s.data && ( s.processData || typeof s.data === "string" ) ) { + cacheURL += ( rquery.test( cacheURL ) ? "&" : "?" ) + s.data; + + // #9682: remove data so that it's not used in an eventual retry + delete s.data; + } + + // Add or update anti-cache param if needed + if ( s.cache === false ) { + cacheURL = cacheURL.replace( rantiCache, "$1" ); + uncached = ( rquery.test( cacheURL ) ? "&" : "?" ) + "_=" + ( nonce.guid++ ) + + uncached; + } + + // Put hash and anti-cache on the URL that will be requested (gh-1732) + s.url = cacheURL + uncached; + + // Change '%20' to '+' if this is encoded form body content (gh-2658) + } else if ( s.data && s.processData && + ( s.contentType || "" ).indexOf( "application/x-www-form-urlencoded" ) === 0 ) { + s.data = s.data.replace( r20, "+" ); + } + + // Set the If-Modified-Since and/or If-None-Match header, if in ifModified mode. + if ( s.ifModified ) { + if ( jQuery.lastModified[ cacheURL ] ) { + jqXHR.setRequestHeader( "If-Modified-Since", jQuery.lastModified[ cacheURL ] ); + } + if ( jQuery.etag[ cacheURL ] ) { + jqXHR.setRequestHeader( "If-None-Match", jQuery.etag[ cacheURL ] ); + } + } + + // Set the correct header, if data is being sent + if ( s.data && s.hasContent && s.contentType !== false || options.contentType ) { + jqXHR.setRequestHeader( "Content-Type", s.contentType ); + } + + // Set the Accepts header for the server, depending on the dataType + jqXHR.setRequestHeader( + "Accept", + s.dataTypes[ 0 ] && s.accepts[ s.dataTypes[ 0 ] ] ? + s.accepts[ s.dataTypes[ 0 ] ] + + ( s.dataTypes[ 0 ] !== "*" ? ", " + allTypes + "; q=0.01" : "" ) : + s.accepts[ "*" ] + ); + + // Check for headers option + for ( i in s.headers ) { + jqXHR.setRequestHeader( i, s.headers[ i ] ); + } + + // Allow custom headers/mimetypes and early abort + if ( s.beforeSend && + ( s.beforeSend.call( callbackContext, jqXHR, s ) === false || completed ) ) { + + // Abort if not done already and return + return jqXHR.abort(); + } + + // Aborting is no longer a cancellation + strAbort = "abort"; + + // Install callbacks on deferreds + completeDeferred.add( s.complete ); + jqXHR.done( s.success ); + jqXHR.fail( s.error ); + + // Get transport + transport = inspectPrefiltersOrTransports( transports, s, options, jqXHR ); + + // If no transport, we auto-abort + if ( !transport ) { + done( -1, "No Transport" ); + } else { + jqXHR.readyState = 1; + + // Send global event + if ( fireGlobals ) { + globalEventContext.trigger( "ajaxSend", [ jqXHR, s ] ); + } + + // If request was aborted inside ajaxSend, stop there + if ( completed ) { + return jqXHR; + } + + // Timeout + if ( s.async && s.timeout > 0 ) { + timeoutTimer = window.setTimeout( function() { + jqXHR.abort( "timeout" ); + }, s.timeout ); + } + + try { + completed = false; + transport.send( requestHeaders, done ); + } catch ( e ) { + + // Rethrow post-completion exceptions + if ( completed ) { + throw e; + } + + // Propagate others as results + done( -1, e ); + } + } + + // Callback for when everything is done + function done( status, nativeStatusText, responses, headers ) { + var isSuccess, success, error, response, modified, + statusText = nativeStatusText; + + // Ignore repeat invocations + if ( completed ) { + return; + } + + completed = true; + + // Clear timeout if it exists + if ( timeoutTimer ) { + window.clearTimeout( timeoutTimer ); + } + + // Dereference transport for early garbage collection + // (no matter how long the jqXHR object will be used) + transport = undefined; + + // Cache response headers + responseHeadersString = headers || ""; + + // Set readyState + jqXHR.readyState = status > 0 ? 4 : 0; + + // Determine if successful + isSuccess = status >= 200 && status < 300 || status === 304; + + // Get response data + if ( responses ) { + response = ajaxHandleResponses( s, jqXHR, responses ); + } + + // Use a noop converter for missing script but not if jsonp + if ( !isSuccess && + jQuery.inArray( "script", s.dataTypes ) > -1 && + jQuery.inArray( "json", s.dataTypes ) < 0 ) { + s.converters[ "text script" ] = function() {}; + } + + // Convert no matter what (that way responseXXX fields are always set) + response = ajaxConvert( s, response, jqXHR, isSuccess ); + + // If successful, handle type chaining + if ( isSuccess ) { + + // Set the If-Modified-Since and/or If-None-Match header, if in ifModified mode. + if ( s.ifModified ) { + modified = jqXHR.getResponseHeader( "Last-Modified" ); + if ( modified ) { + jQuery.lastModified[ cacheURL ] = modified; + } + modified = jqXHR.getResponseHeader( "etag" ); + if ( modified ) { + jQuery.etag[ cacheURL ] = modified; + } + } + + // if no content + if ( status === 204 || s.type === "HEAD" ) { + statusText = "nocontent"; + + // if not modified + } else if ( status === 304 ) { + statusText = "notmodified"; + + // If we have data, let's convert it + } else { + statusText = response.state; + success = response.data; + error = response.error; + isSuccess = !error; + } + } else { + + // Extract error from statusText and normalize for non-aborts + error = statusText; + if ( status || !statusText ) { + statusText = "error"; + if ( status < 0 ) { + status = 0; + } + } + } + + // Set data for the fake xhr object + jqXHR.status = status; + jqXHR.statusText = ( nativeStatusText || statusText ) + ""; + + // Success/Error + if ( isSuccess ) { + deferred.resolveWith( callbackContext, [ success, statusText, jqXHR ] ); + } else { + deferred.rejectWith( callbackContext, [ jqXHR, statusText, error ] ); + } + + // Status-dependent callbacks + jqXHR.statusCode( statusCode ); + statusCode = undefined; + + if ( fireGlobals ) { + globalEventContext.trigger( isSuccess ? "ajaxSuccess" : "ajaxError", + [ jqXHR, s, isSuccess ? success : error ] ); + } + + // Complete + completeDeferred.fireWith( callbackContext, [ jqXHR, statusText ] ); + + if ( fireGlobals ) { + globalEventContext.trigger( "ajaxComplete", [ jqXHR, s ] ); + + // Handle the global AJAX counter + if ( !( --jQuery.active ) ) { + jQuery.event.trigger( "ajaxStop" ); + } + } + } + + return jqXHR; + }, + + getJSON: function( url, data, callback ) { + return jQuery.get( url, data, callback, "json" ); + }, + + getScript: function( url, callback ) { + return jQuery.get( url, undefined, callback, "script" ); + } +} ); + +jQuery.each( [ "get", "post" ], function( _i, method ) { + jQuery[ method ] = function( url, data, callback, type ) { + + // Shift arguments if data argument was omitted + if ( isFunction( data ) ) { + type = type || callback; + callback = data; + data = undefined; + } + + // The url can be an options object (which then must have .url) + return jQuery.ajax( jQuery.extend( { + url: url, + type: method, + dataType: type, + data: data, + success: callback + }, jQuery.isPlainObject( url ) && url ) ); + }; +} ); + +jQuery.ajaxPrefilter( function( s ) { + var i; + for ( i in s.headers ) { + if ( i.toLowerCase() === "content-type" ) { + s.contentType = s.headers[ i ] || ""; + } + } +} ); + + +jQuery._evalUrl = function( url, options, doc ) { + return jQuery.ajax( { + url: url, + + // Make this explicit, since user can override this through ajaxSetup (#11264) + type: "GET", + dataType: "script", + cache: true, + async: false, + global: false, + + // Only evaluate the response if it is successful (gh-4126) + // dataFilter is not invoked for failure responses, so using it instead + // of the default converter is kludgy but it works. + converters: { + "text script": function() {} + }, + dataFilter: function( response ) { + jQuery.globalEval( response, options, doc ); + } + } ); +}; + + +jQuery.fn.extend( { + wrapAll: function( html ) { + var wrap; + + if ( this[ 0 ] ) { + if ( isFunction( html ) ) { + html = html.call( this[ 0 ] ); + } + + // The elements to wrap the target around + wrap = jQuery( html, this[ 0 ].ownerDocument ).eq( 0 ).clone( true ); + + if ( this[ 0 ].parentNode ) { + wrap.insertBefore( this[ 0 ] ); + } + + wrap.map( function() { + var elem = this; + + while ( elem.firstElementChild ) { + elem = elem.firstElementChild; + } + + return elem; + } ).append( this ); + } + + return this; + }, + + wrapInner: function( html ) { + if ( isFunction( html ) ) { + return this.each( function( i ) { + jQuery( this ).wrapInner( html.call( this, i ) ); + } ); + } + + return this.each( function() { + var self = jQuery( this ), + contents = self.contents(); + + if ( contents.length ) { + contents.wrapAll( html ); + + } else { + self.append( html ); + } + } ); + }, + + wrap: function( html ) { + var htmlIsFunction = isFunction( html ); + + return this.each( function( i ) { + jQuery( this ).wrapAll( htmlIsFunction ? html.call( this, i ) : html ); + } ); + }, + + unwrap: function( selector ) { + this.parent( selector ).not( "body" ).each( function() { + jQuery( this ).replaceWith( this.childNodes ); + } ); + return this; + } +} ); + + +jQuery.expr.pseudos.hidden = function( elem ) { + return !jQuery.expr.pseudos.visible( elem ); +}; +jQuery.expr.pseudos.visible = function( elem ) { + return !!( elem.offsetWidth || elem.offsetHeight || elem.getClientRects().length ); +}; + + + + +jQuery.ajaxSettings.xhr = function() { + try { + return new window.XMLHttpRequest(); + } catch ( e ) {} +}; + +var xhrSuccessStatus = { + + // File protocol always yields status code 0, assume 200 + 0: 200, + + // Support: IE <=9 only + // #1450: sometimes IE returns 1223 when it should be 204 + 1223: 204 + }, + xhrSupported = jQuery.ajaxSettings.xhr(); + +support.cors = !!xhrSupported && ( "withCredentials" in xhrSupported ); +support.ajax = xhrSupported = !!xhrSupported; + +jQuery.ajaxTransport( function( options ) { + var callback, errorCallback; + + // Cross domain only allowed if supported through XMLHttpRequest + if ( support.cors || xhrSupported && !options.crossDomain ) { + return { + send: function( headers, complete ) { + var i, + xhr = options.xhr(); + + xhr.open( + options.type, + options.url, + options.async, + options.username, + options.password + ); + + // Apply custom fields if provided + if ( options.xhrFields ) { + for ( i in options.xhrFields ) { + xhr[ i ] = options.xhrFields[ i ]; + } + } + + // Override mime type if needed + if ( options.mimeType && xhr.overrideMimeType ) { + xhr.overrideMimeType( options.mimeType ); + } + + // X-Requested-With header + // For cross-domain requests, seeing as conditions for a preflight are + // akin to a jigsaw puzzle, we simply never set it to be sure. + // (it can always be set on a per-request basis or even using ajaxSetup) + // For same-domain requests, won't change header if already provided. + if ( !options.crossDomain && !headers[ "X-Requested-With" ] ) { + headers[ "X-Requested-With" ] = "XMLHttpRequest"; + } + + // Set headers + for ( i in headers ) { + xhr.setRequestHeader( i, headers[ i ] ); + } + + // Callback + callback = function( type ) { + return function() { + if ( callback ) { + callback = errorCallback = xhr.onload = + xhr.onerror = xhr.onabort = xhr.ontimeout = + xhr.onreadystatechange = null; + + if ( type === "abort" ) { + xhr.abort(); + } else if ( type === "error" ) { + + // Support: IE <=9 only + // On a manual native abort, IE9 throws + // errors on any property access that is not readyState + if ( typeof xhr.status !== "number" ) { + complete( 0, "error" ); + } else { + complete( + + // File: protocol always yields status 0; see #8605, #14207 + xhr.status, + xhr.statusText + ); + } + } else { + complete( + xhrSuccessStatus[ xhr.status ] || xhr.status, + xhr.statusText, + + // Support: IE <=9 only + // IE9 has no XHR2 but throws on binary (trac-11426) + // For XHR2 non-text, let the caller handle it (gh-2498) + ( xhr.responseType || "text" ) !== "text" || + typeof xhr.responseText !== "string" ? + { binary: xhr.response } : + { text: xhr.responseText }, + xhr.getAllResponseHeaders() + ); + } + } + }; + }; + + // Listen to events + xhr.onload = callback(); + errorCallback = xhr.onerror = xhr.ontimeout = callback( "error" ); + + // Support: IE 9 only + // Use onreadystatechange to replace onabort + // to handle uncaught aborts + if ( xhr.onabort !== undefined ) { + xhr.onabort = errorCallback; + } else { + xhr.onreadystatechange = function() { + + // Check readyState before timeout as it changes + if ( xhr.readyState === 4 ) { + + // Allow onerror to be called first, + // but that will not handle a native abort + // Also, save errorCallback to a variable + // as xhr.onerror cannot be accessed + window.setTimeout( function() { + if ( callback ) { + errorCallback(); + } + } ); + } + }; + } + + // Create the abort callback + callback = callback( "abort" ); + + try { + + // Do send the request (this may raise an exception) + xhr.send( options.hasContent && options.data || null ); + } catch ( e ) { + + // #14683: Only rethrow if this hasn't been notified as an error yet + if ( callback ) { + throw e; + } + } + }, + + abort: function() { + if ( callback ) { + callback(); + } + } + }; + } +} ); + + + + +// Prevent auto-execution of scripts when no explicit dataType was provided (See gh-2432) +jQuery.ajaxPrefilter( function( s ) { + if ( s.crossDomain ) { + s.contents.script = false; + } +} ); + +// Install script dataType +jQuery.ajaxSetup( { + accepts: { + script: "text/javascript, application/javascript, " + + "application/ecmascript, application/x-ecmascript" + }, + contents: { + script: /\b(?:java|ecma)script\b/ + }, + converters: { + "text script": function( text ) { + jQuery.globalEval( text ); + return text; + } + } +} ); + +// Handle cache's special case and crossDomain +jQuery.ajaxPrefilter( "script", function( s ) { + if ( s.cache === undefined ) { + s.cache = false; + } + if ( s.crossDomain ) { + s.type = "GET"; + } +} ); + +// Bind script tag hack transport +jQuery.ajaxTransport( "script", function( s ) { + + // This transport only deals with cross domain or forced-by-attrs requests + if ( s.crossDomain || s.scriptAttrs ) { + var script, callback; + return { + send: function( _, complete ) { + script = jQuery( " + Skip to contents + + +
    +
    +
    +

    add_database_info Assign passed databases db metadata to passed dvobject

    + Source: R/dvobject_metadata.R +
    add_database_info.Rd
    +
    + +
    +

    add_database_info + Assign passed databases db metadata to passed dvobject

    +
    + +
    +

    Usage

    + 
    add_database_info(
+  dvobject,
+  db_type = "DrugBank",
+  db_version = NULL,
+  db_exported_date = NULL
+)
    +
    + +
    +

    Arguments

    + + +
    dvobject
    +

    dvobject to assign metadata to it

    + + +
    db_type
    +

    database type (defualt="DrugBank")

    + + +
    db_version
    +

    database version as string

    + + +
    db_exported_date
    +

    database official export date

    + +
    +
    +

    Value

    +

    dvobject

    +
    +
    +

    See also

    +

    Other utility: +show_dvobject_metadata(), +subset_drugbank_dvobject(), +subset_onsides_dvobject()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/add_database_info.md b/docs/reference/add_database_info.md new file mode 100644 index 0000000..612ba27 --- /dev/null +++ b/docs/reference/add_database_info.md @@ -0,0 +1,43 @@ +# add_database_info Assign passed databases db metadata to passed dvobject + +add_database_info Assign passed databases db metadata to passed dvobject + +## Usage + +``` r +add_database_info( + dvobject, + db_type = "DrugBank", + db_version = NULL, + db_exported_date = NULL +) +``` + +## Arguments + +- dvobject: + + dvobject to assign metadata to it + +- db_type: + + database type (defualt="DrugBank") + +- db_version: + + database version as string + +- db_exported_date: + + database official export date + +## Value + +dvobject + +## See also + +Other utility: +[`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md), +[`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md), +[`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) diff --git a/docs/reference/articles.md b/docs/reference/articles.md new file mode 100644 index 0000000..5a308f8 --- /dev/null +++ b/docs/reference/articles.md @@ -0,0 +1,39 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser + +Return a list of articles that were used as references for drugs +carriers + +## Usage + +``` r +drugs_articles() + +carriers_articles() + +enzymes_articles() + +targets_articles() + +transporters_articles() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Identifier for the article being referenced. This is unique across all + reference types (books, links, article, attachments). + +- pubmed-id: + + The PubMed identifier for the article. + +- citation: + + Article citation in a standard format. + +- *parent_id*: + + drug/carrier/target/enzyme/transporter id diff --git a/docs/reference/attachments.md b/docs/reference/attachments.md new file mode 100644 index 0000000..1a4da53 --- /dev/null +++ b/docs/reference/attachments.md @@ -0,0 +1,39 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser + +Return a list of attachment that were used as references for drugs +carriers + +## Usage + +``` r +drugs_attachments() + +carriers_attachments() + +enzymes_attachments() + +targets_attachments() + +transporters_attachments() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Identifier for the article being referenced. This is unique across all + reference types (books, links, article, attachments). + +- title: + + The title of the attachment. + +- url: + + The url to download the attachment from. + +- *parent_id*: + + drug/carrier/target/enzyme/transporter id diff --git a/docs/reference/books.md b/docs/reference/books.md new file mode 100644 index 0000000..0dc9c15 --- /dev/null +++ b/docs/reference/books.md @@ -0,0 +1,39 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser + +Return a list of text books that were used as references for drugs, +carriers, enzymes, targets or transporters + +## Usage + +``` r +drugs_textbooks() + +carriers_textbooks() + +enzymes_textbooks() + +targets_textbooks() + +transporters_textbooks() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Identifier for the article being referenced. This is unique across all + reference types (books, links, article, attachments). + +- isbn: + + ISBN identifying the textbook. + +- citation: + + A Textbook citation in a standard format. + +- *parent_id*: + + drug/ carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/build_metadata.html b/docs/reference/build_metadata.html new file mode 100644 index 0000000..40d6bee --- /dev/null +++ b/docs/reference/build_metadata.html @@ -0,0 +1,90 @@ + +Build Metadata Data Frame — build_metadata • dbparser + Skip to contents + + +
    +
    +
    +

    Build Metadata Data Frame

    + Source: R/dvobject_metadata.R +
    build_metadata.Rd
    +
    + +
    +

    Build Metadata Data Frame

    +
    + +
    +

    Usage

    + 
    build_metadata(attrs, has_second_db, second_db_name)
    +
    + +
    +

    Arguments

    + + +
    attrs
    +

    Attributes list

    + + +
    has_second_db
    +

    Logical indicating if second database exists

    + + +
    second_db_name
    +

    Name of second database attribute

    + +
    +
    +

    Value

    +

    Data.frame with database metadata

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/build_metadata.md b/docs/reference/build_metadata.md new file mode 100644 index 0000000..a76d998 --- /dev/null +++ b/docs/reference/build_metadata.md @@ -0,0 +1,27 @@ +# Build Metadata Data Frame + +Build Metadata Data Frame + +## Usage + +``` r +build_metadata(attrs, has_second_db, second_db_name) +``` + +## Arguments + +- attrs: + + Attributes list + +- has_second_db: + + Logical indicating if second database exists + +- second_db_name: + + Name of second database attribute + +## Value + +Data.frame with database metadata diff --git a/docs/reference/carriers_attachments.html b/docs/reference/carriers_attachments.html new file mode 100644 index 0000000..2066a85 --- /dev/null +++ b/docs/reference/carriers_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/carriers_polypep_ex_ident.html b/docs/reference/carriers_polypep_ex_ident.html new file mode 100644 index 0000000..7fd02f4 --- /dev/null +++ b/docs/reference/carriers_polypep_ex_ident.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/carriers_polypeptides.html b/docs/reference/carriers_polypeptides.html new file mode 100644 index 0000000..554cbd6 --- /dev/null +++ b/docs/reference/carriers_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/cett_actions_doc.md b/docs/reference/cett_actions_doc.md new file mode 100644 index 0000000..d90e050 --- /dev/null +++ b/docs/reference/cett_actions_doc.md @@ -0,0 +1,27 @@ +# Carriers/ Enzymes/ Targets/ Transporters Actions parsers + +Collection of related actions + +## Usage + +``` r +carriers_actions() + +enzymes_actions() + +targets_actions() + +transporters_actions() +``` + +## Value + +a tibble with 2 variables: + +- action: + + describe related action + +- *parent_id*: + + carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/cett_doc.md b/docs/reference/cett_doc.md new file mode 100644 index 0000000..3f33682 --- /dev/null +++ b/docs/reference/cett_doc.md @@ -0,0 +1,56 @@ +# Carriers/ Enzymes/ Targets/ Transporters parsers + +Protein targets of drug action, enzymes that are inhibited/induced or +involved in metabolism, and carrier or transporter proteins involved in +movement of the drug across biological membranes. + +## Usage + +``` r +carriers() + +enzymes() + +targets() + +transporters() +``` + +## Value + +a tibble with 6 variables (8 for enzymes): + +- id: + + Universal Protein Resource (UniProt) Identifier for the record + +- name: + + related name + +- organism: + + Organism that the protein comes from. + +- known_action: + + Whether the pharmacological action of the drug is due to this target + interaction. + +- inhibition-strength: + + Whether the strength of enzyme inhibition is strong, moderate, or + unknown. **Only applies to enzymes** + +- induction-strength: + + Whether the strength of enzyme induction is strong or unknown. **Only + applies to enzymes** + +- position: + + related position + +- parent_id: + + drugbank id diff --git a/docs/reference/cett_ex_identity_doc.md b/docs/reference/cett_ex_identity_doc.md new file mode 100644 index 0000000..a33d971 --- /dev/null +++ b/docs/reference/cett_ex_identity_doc.md @@ -0,0 +1,32 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers + +Extract descriptions of identified polypeptide external identifiers for +targets, enzymes, carriers, or transporters. + +## Usage + +``` r +carriers_polypep_ex_ident() + +enzymes_polypep_ex_ident() + +targets_polypep_ex_ident() + +transporters_polypep_ex_ident() +``` + +## Value + +a tibble with 3 variables: + +- resource: + + Name of the source database. + +- identifier: + + Identifier for this drug in the given resource. + +- parent_key: + + polypeptide id diff --git a/docs/reference/cett_go_doc.md b/docs/reference/cett_go_doc.md new file mode 100644 index 0000000..cb20853 --- /dev/null +++ b/docs/reference/cett_go_doc.md @@ -0,0 +1,28 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers + +Extract descriptions of identified polypeptide go classifier for +targets, enzymes, carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides_go() + +enzymes_polypeptides_go() + +targets_polypeptides_go() + +transporters_polypeptides_go() +``` + +## Value + +a tibble with 3 variables: + +- category: + +- description: + +- parent_key: + + polypeptide id diff --git a/docs/reference/cett_nodes_options.md b/docs/reference/cett_nodes_options.md new file mode 100644 index 0000000..27f26ea --- /dev/null +++ b/docs/reference/cett_nodes_options.md @@ -0,0 +1,22 @@ +# returns carriers, enzymes,targets and transporters node valid options. + +returns carriers, enzymes,targets and transporters node valid options. + +## Usage + +``` r +cett_nodes_options() +``` + +## Value + +list of CETT valid options + +## See also + +Other parsers: +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/cett_poly_doc.md b/docs/reference/cett_poly_doc.md new file mode 100644 index 0000000..7c0decb --- /dev/null +++ b/docs/reference/cett_poly_doc.md @@ -0,0 +1,99 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers + +Extract descriptions of identified polypeptide targets, enzymes, +carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides() + +enzymes_polypeptides() + +targets_polypeptides() + +transporters_polypeptides() +``` + +## Value + +a tibble with 20 variables: + +- id: + + [Universal Protein Resource (UniProt) + identifier](https://www.uniprot.org/) + +- source: + + Specifies whether the identified polypeptide ID is associated with any + of the following UniProt knowledge bases: Swiss-Prot, which is + manually annotated and reviewed, or TrEMBL, which is automatically + annotated and not reviewed. + +- name: + +- general_function: + + General summary of the physiological function of the polypeptide + +- specific_function: + + A more specific description of the polypeptide’s physiological + function within the cell. + +- gene_name: + + The short name commonly associated with the associated gene. Eg. + PTGS1. + +- locus: + + The specific chromosomal location or position of the gene’s sequence + on a chromosome. + +- cellular_location: + + The cellular location of the polypeptide. + +- transmembrane_regions: + + Areas of the polypeptide sequence that span a biological membrane. + +- signal_regions: + + Location of any signal peptides within the polypeptide sequence. + +- theoretical_pi: + + Theoretical isoelectric point. + +- molecular_weight: + + The molecular weight of the polypeptide. + +- chromosome_location: + + The chromosomal location of the polypeptide gene + +- organism: + + The organism in which this polypeptide functions. + +- organism_ncbi_taxonomy_id: + +- amino_acid_sequence: + + The amino acid sequence of the polypeptide + +- amino_acid_format: + +- gene_sequence: + + The sequence of the associated gene. + +- gene_format: + +- parent_key: + + carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/cett_poly_pfms_doc.md b/docs/reference/cett_poly_pfms_doc.md new file mode 100644 index 0000000..dea2bd1 --- /dev/null +++ b/docs/reference/cett_poly_pfms_doc.md @@ -0,0 +1,30 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers + +Extract descriptions of identified polypeptide PFAMS targets, enzymes, +carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides_pfams() + +enzymes_polypeptides_pfams() + +targets_polypeptides_pfams() + +transporters_polypeptides_pfams() +``` + +## Value + +a tibble with 3 variables: + +- name: + + The sequence of the associated gene. + +- identifier: + +- parent_key: + + polypeptide id diff --git a/docs/reference/cett_poly_syn_doc.md b/docs/reference/cett_poly_syn_doc.md new file mode 100644 index 0000000..6926b1d --- /dev/null +++ b/docs/reference/cett_poly_syn_doc.md @@ -0,0 +1,26 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers + +Extract descriptions of identified polypeptide synonyms for targets, +enzymes, carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides_syn() + +enzymes_polypeptides_syn() + +targets_polypeptides_syn() + +transporters_polypeptides_syn() +``` + +## Value + +a tibble with 2 variables: + +- synonym: + +- parent_key: + + polypeptide id diff --git a/docs/reference/count_top_level_lists.html b/docs/reference/count_top_level_lists.html new file mode 100644 index 0000000..c97398d --- /dev/null +++ b/docs/reference/count_top_level_lists.html @@ -0,0 +1,82 @@ + +Count Top Level Lists — count_top_level_lists • dbparser + Skip to contents + + +
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    Count Top Level Lists

    + Source: R/dvobject_metadata.R +
    count_top_level_lists.Rd
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    Count Top Level Lists

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    Usage

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    count_top_level_lists(obj)
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    Arguments

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    Object to analyze

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    Value

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    Integer count of top-level lists (excluding data.frames)

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    + + + + + + + diff --git a/docs/reference/count_top_level_lists.md b/docs/reference/count_top_level_lists.md new file mode 100644 index 0000000..ffe282e --- /dev/null +++ b/docs/reference/count_top_level_lists.md @@ -0,0 +1,19 @@ +# Count Top Level Lists + +Count Top Level Lists + +## Usage + +``` r +count_top_level_lists(obj) +``` + +## Arguments + +- obj: + + Object to analyze + +## Value + +Integer count of top-level lists (excluding data.frames) diff --git a/docs/reference/dbparser-package.html b/docs/reference/dbparser-package.html new file mode 100644 index 0000000..e230be1 --- /dev/null +++ b/docs/reference/dbparser-package.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/dbparser.md b/docs/reference/dbparser.md new file mode 100644 index 0000000..08a2cfd --- /dev/null +++ b/docs/reference/dbparser.md @@ -0,0 +1,56 @@ +# dbparser: A package for reading and parsing **DrugBank** xml database. + +The main purpose of the \`dbparser\` package is to parse +\[DrugBank\](https://go.drugbank.com/) database which is downloadable in +XML format from \[this link\](https://go.drugbank.com/releases/latest). + +## Details + +The parsed data can then be explored and analyzed. + +To achieve this purpose, \`dbparser“ package provides three main +categories of functions: + +\- xml db reader, + +\- **DrugBank** elements parsers, + +For more information kindly check the reference/index +(https://docs.ropensci.org/dbparser/reference/index.html) + +## xml db reader functions + +Reads **DrugBank** xml database and build drug elements full tree in +memory + +## parsers functions + +Each parser function is responsible of parsing certain drug element and +returning its tibble. + +Check this tutorial +(https://docs.ropensci.org/dbparser/articles/dbparser.html) + +## See also + +Useful links: + +- + +- + +- Report bugs at + +## Author + +**Maintainer**: Mohammed Ali + +Authors: + +- Ali Ezzat + +Other contributors: + +- Hao Zhu \[reviewer\] + +- Emma Mendelsohn \[reviewer\] diff --git a/docs/reference/drug_affected_organisms.md b/docs/reference/drug_affected_organisms.md new file mode 100644 index 0000000..1b411a2 --- /dev/null +++ b/docs/reference/drug_affected_organisms.md @@ -0,0 +1,22 @@ +# Drug Affected Organism parser + +Organisms in which the drug may display activity; activity may depend on +local susceptibility patterns and resistance. + +## Usage + +``` r +drug_affected_organisms() +``` + +## Value + +a tibble with 2 variables: + +- affected-organism: + + affected-organism name + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_ahfs_codes.md b/docs/reference/drug_ahfs_codes.md new file mode 100644 index 0000000..2f7f820 --- /dev/null +++ b/docs/reference/drug_ahfs_codes.md @@ -0,0 +1,19 @@ +# Drug ahfs-codes parser + +The American Hospital Formulary Service (AHFS) identifier for this drug. + +## Usage + +``` r +drug_ahfs_codes() +``` + +## Value + +a tibble with the following variables: + +- ahfs-code: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_atc_codes.md b/docs/reference/drug_atc_codes.md new file mode 100644 index 0000000..741906b --- /dev/null +++ b/docs/reference/drug_atc_codes.md @@ -0,0 +1,21 @@ +# Drug ATC Codes element parser + +The Anatomical Therapeutic Classification (ATC) code for the drug +assigned by the World Health Organization Anatomical Chemical +Classification System. + +## Usage + +``` r +drug_atc_codes() +``` + +## Value + +a tibble with 10 variables + +## Details + +Each \`atc-code“ row has one or more level. The atc-code and level\> +have a code the code assigned by the World Health Organization +Anatomical Therapeutic Chemical Classification system. diff --git a/docs/reference/drug_calc_prop.md b/docs/reference/drug_calc_prop.md new file mode 100644 index 0000000..ec1e4f6 --- /dev/null +++ b/docs/reference/drug_calc_prop.md @@ -0,0 +1,33 @@ +# Drug Calculated Properties parser + +Drug properties that have been predicted by ChemAxon or ALOGPS based on +the imputed chemical structure. Associated links below will redirect to +descriptions of the specific term. + +## Usage + +``` r +drug_calc_prop() +``` + +## Value + +a tibble with 4 variables: + +- kind: + + Name of the property. + +- value: + + Predicted physicochemical properties; obtained by the use of + prediction software such as ALGOPS and ChemAxon. + +- source: + + Name of the software used to calculate this property, either ChemAxon + or ALOGPS. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_categories.md b/docs/reference/drug_categories.md new file mode 100644 index 0000000..299c1c4 --- /dev/null +++ b/docs/reference/drug_categories.md @@ -0,0 +1,25 @@ +# Drug Categories parser + +General categorizations of the drug. + +## Usage + +``` r +drug_categories() +``` + +## Value + +a tibble with 2 variables: + +- category: + + category name + +- mesh-id: + + The Medical Subjects Headings (MeSH) identifier for the category. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_classification.md b/docs/reference/drug_classification.md new file mode 100644 index 0000000..025b1cd --- /dev/null +++ b/docs/reference/drug_classification.md @@ -0,0 +1,38 @@ +# Drug Classification parser + +A description of the hierarchical chemical classification of the drug; +imported from ClassyFire. + +## Usage + +``` r +drug_classification() +``` + +## Value + +a tibble with 9 variables: + +- description: + +- direct-parent: + +- kingdom: + +- superclass: + +- class: + +- subclass: + +- alternative-parent: + + One or more alternative parents + +- substituent: + + One or more substituents + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_dosages.md b/docs/reference/drug_dosages.md new file mode 100644 index 0000000..1582223 --- /dev/null +++ b/docs/reference/drug_dosages.md @@ -0,0 +1,30 @@ +# Drug Dosages parser + +A list of the commercially available dosages of the drug. + +## Usage + +``` r +drug_dosages() +``` + +## Value + +a tibble with the following variables: + +- form: + + The pharmaceutical formulation by which the drug is introduced into + the body + +- route: + + The path by which the drug or product is taken into the body. + +- strength: + + The amount of active drug ingredient provided in the dosage + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_ex_identity.md b/docs/reference/drug_ex_identity.md new file mode 100644 index 0000000..fb40c1a --- /dev/null +++ b/docs/reference/drug_ex_identity.md @@ -0,0 +1,26 @@ +# Drug External Identifiers parser + +Identifiers used in other websites or databases providing information +about this drug. + +## Usage + +``` r +drug_ex_identity() +``` + +## Value + +a tibble with the following variables: + +- resource: + + Name of the source database. + +- identifier: + + Identifier for this drug in the given resource. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_exp_prop.md b/docs/reference/drug_exp_prop.md new file mode 100644 index 0000000..57d62e2 --- /dev/null +++ b/docs/reference/drug_exp_prop.md @@ -0,0 +1,91 @@ +# Drug Experimental Properties parser + +Drug properties that have been experimentally proven + +## Usage + +``` r +drug_exp_prop() +``` + +## Value + +a tibble with the following variables: + +- kind: + + Name of the property. + +- value: + + Drug properties that have been experimentally proven. + +- source: + + Reference to the source of this experimental data. + +- *drugbank_id*: + + drugbank id + +The following experimental properties are provided: + +- Water Solubility: + + The experimentally determined aqueous solubility of the molecule. + +- Molecular Formula: + + Protein formula of Biotech drugs + +- Molecular Weight: + + Protein weight of Biotech drugs. + +- Melting Point: + + The experimentally determined temperature at which the drug molecule + changes from solid to liquid at atmospheric temperature. + +- Boiling Point: + + The experimentally determined temperature at which the drug molecule + changes from liquid to gas at atmospheric temperature. + +- Hydrophobicity: + + The ability of a molecule to repel water rather than absorb or + dissolve water. + +- Isoelectric Point: + + The pH value at which the net electric charge of a molecule is zero. + +- caco2 Permeability: + + A continuous line of heterogenous human epithelial colorectal + adenocarcinoma cells, CAC02 cells are employed as a model of human + intestinal absorption of various drugs and compounds. CAC02 cell + permeability is ultimately an assay to measure drug absorption. + +- pKa: + + The experimentally determined pka value of the molecule + +- logP: + + The experimentally determined partition coefficient (LogP) based on + the ratio of solubility of the molecule in 1-octanol compared to + water. + +- logS: + + The intrinsic solubility of a given compound is the concentration in + equilibrium with its solid phase that dissolves into solution, given + as the natural logarithm (LogS) of the concentration. + +- Radioactivity: + + The property to spontaneously emit particles (alpha, beta, neutron) or + radiation (gamma, K capture), or both at the same time, from the decay + of certain nuclides. diff --git a/docs/reference/drug_external_links.md b/docs/reference/drug_external_links.md new file mode 100644 index 0000000..816c333 --- /dev/null +++ b/docs/reference/drug_external_links.md @@ -0,0 +1,26 @@ +# Drug External Links parser + +Links to other websites or databases providing information about this +drug. + +## Usage + +``` r +drug_external_links() +``` + +## Value + +a tibble with the following variables: + +- resource: + + Name of the source website. + +- identifier: + + Identifier for this drug in the given resource + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_food_interactions.md b/docs/reference/drug_food_interactions.md new file mode 100644 index 0000000..ae88d23 --- /dev/null +++ b/docs/reference/drug_food_interactions.md @@ -0,0 +1,19 @@ +# Drug Groups parser + +Food that may interact with this drug. + +## Usage + +``` r +drug_food_interactions() +``` + +## Value + +a tibble with the following variables: + +- food-interaction: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_general_information.md b/docs/reference/drug_general_information.md new file mode 100644 index 0000000..0d36c92 --- /dev/null +++ b/docs/reference/drug_general_information.md @@ -0,0 +1,79 @@ +# Drugs General Information parser + +A description of the hierarchical chemical classification of the drug; +imported from ClassyFire. + +## Usage + +``` r +drug_general_information() +``` + +## Value + +a tibble with 15 variables: + +- primary_key: + + DrugBank id + +- other_keys: + + Other identifiers that may be associated with the drug + +- type: + + Either small molecule, or biotech. Biotech is used for any drug that + is derived from living systems or organisms, usually composed of high + molecular weight mixtures of protein, while small molecule describes a + low molecular weight organic compound. + +- name: + +- created: + + Date that this drug was first added to DrugBank. + +- updated: + + Denotes when this drug was last updated in DrugBank. + +- description: + + Descriptions of drug chemical properties, history and regulatory + status. + +- cas_number: + + The Chemical Abstracts Service (CAS) registry number assigned to the + drug. + +- *unii*: + + Unique Ingredient Identifier (UNII) of this drug. + +- average_mass: + + The weighted average of the isotopic masses of the drug + +- state: + + One of solid, liquid, or gas + +- monoisotopic_mass: + + The mass of the most abundant isotope of the drug + +- synthesis_reference: + + Citation for synthesis of the drug molecule. + +- fda_label: + + Contains a URL for accessing the uploaded United States Food and Drug + Administration (FDA) Monograph for this drug. + +- msds: + + Contains a URL for accessing the Material Safety Data Sheet (MSDS) for + this drug. diff --git a/docs/reference/drug_groups.md b/docs/reference/drug_groups.md new file mode 100644 index 0000000..f96a0b0 --- /dev/null +++ b/docs/reference/drug_groups.md @@ -0,0 +1,21 @@ +# Drug Groups parser + +Groups that this drug belongs to. May include any of: approved, +vet_approved, nutraceutical, illicit, withdrawn, investigational, and +experimental. + +## Usage + +``` r +drug_groups() +``` + +## Value + +a tibble with 2 variables: + +- group: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_interactions.md b/docs/reference/drug_interactions.md new file mode 100644 index 0000000..19175b4 --- /dev/null +++ b/docs/reference/drug_interactions.md @@ -0,0 +1,34 @@ +# Drug Interactions parser + +Drug-drug interactions detailing drugs that, when administered +concomitantly with the drug of interest, will affect its activity or +result in adverse effects. These interactions may be synergistic or +antagonistic depending on the physiological effects and mechanism of +action of each drug. + +## Usage + +``` r +drug_interactions() +``` + +## Value + +a tibble with the following variables: + +- drugbank-id : + + DrugBank ID of the interacting drug. + +- name: + + Name of the interacting drug. + +- description: + + Textual description of the physiological consequences of the drug + interaction + +- *drugbank_id*: + + parent drugbank id diff --git a/docs/reference/drug_intern_brand.md b/docs/reference/drug_intern_brand.md new file mode 100644 index 0000000..8e3a403 --- /dev/null +++ b/docs/reference/drug_intern_brand.md @@ -0,0 +1,28 @@ +# Drug International Brands parser + +The proprietary names used by the manufacturers for commercially +available forms of the drug, focusing on brand names for products that +are available in countries other than Canada and the Unites States. + +## Usage + +``` r +drug_intern_brand() +``` + +## Value + +a tibble with 4 variables: + +- brand: + + The proprietary, well-known name for given to this drug by a + manufacturer. + +- company: + + The company or manufacturer that uses this name. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_manufacturers.md b/docs/reference/drug_manufacturers.md new file mode 100644 index 0000000..8f21f70 --- /dev/null +++ b/docs/reference/drug_manufacturers.md @@ -0,0 +1,27 @@ +# Drug Manufacturers parser + +A list of companies that are manufacturing the commercially available +forms of this drug that are available in Canada and the Unites States. + +## Usage + +``` r +drug_manufacturers() +``` + +## Value + +a tibble with the following variables: + +- generic: + + A list of companies that are manufacturing the generic form of the + drug. + +- url: + + A link to the companies that are manufacturing the drug. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_mixtures.md b/docs/reference/drug_mixtures.md new file mode 100644 index 0000000..9dbec08 --- /dev/null +++ b/docs/reference/drug_mixtures.md @@ -0,0 +1,33 @@ +# Drug Mixtures parser + +All commercially available products in which this drug is available in +combination with other drug molecules + +## Usage + +``` r +drug_mixtures() +``` + +## Value + +a tibble with 4 variables: + +- name: + + The proprietary name provided by the manufacturer for this combination + product. + +- ingredients: + + A list of ingredients, separated by addition symbols + +- supplemental-ingredients: + + List of additional active ingredients which are not clinically + relevant to the main indication of the product, separated by addition + symbols. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_node_options.md b/docs/reference/drug_node_options.md new file mode 100644 index 0000000..f36ddfb --- /dev/null +++ b/docs/reference/drug_node_options.md @@ -0,0 +1,22 @@ +# returns drug node valid options. + +returns drug node valid options. + +## Usage + +``` r +drug_node_options() +``` + +## Value + +list of drug valid options + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/drug_packagers.md b/docs/reference/drug_packagers.md new file mode 100644 index 0000000..e8bdc98 --- /dev/null +++ b/docs/reference/drug_packagers.md @@ -0,0 +1,24 @@ +# Drug Packagers parser + +A list of companies that are packaging the drug for re-distribution. + +## Usage + +``` r +drug_packagers() +``` + +## Value + +a tibble with 2 variables: + +- name: + +- url: + + A link to any companies that are packaging the drug for + re-distribution. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_patents.md b/docs/reference/drug_patents.md new file mode 100644 index 0000000..9242ef0 --- /dev/null +++ b/docs/reference/drug_patents.md @@ -0,0 +1,42 @@ +# Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. + +Drug Patents parser A property right issued by the United States Patent +and Trademark Office (USPTO) to an inventor for a limited time, in +exchange for public disclosure of the invention when the patent is +granted. Drugs may be issued multiple patents. + +## Usage + +``` r +drug_patents() +``` + +## Value + +a tibble with the following variables: + +- number: + + The patent number(s) associated with the drug. + +- country: + + The country that issued the patent rights. + +- approved: + + The date that the patent request was filed. + +- expires: + + The date that the patent rights expire. + +- pediatric-extension: + + Indicates whether or not a pediatric extension has been approved for + the patent. Granted pediatric extensions provide an additional 6 + months of market protection. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_pathway.md b/docs/reference/drug_pathway.md new file mode 100644 index 0000000..75b37de --- /dev/null +++ b/docs/reference/drug_pathway.md @@ -0,0 +1,30 @@ +# Drug Pathway parser + +Metabolic, disease, and biological pathways that the drug is involved +in, as identified by the Small Molecule Protein Database (SMPDB). + +## Usage + +``` r +drug_pathway() +``` + +## Value + +a tibble with the following variables: + +- smpdb-id: + + Small Molecule Pathway Database identifier for this pathway. + +- name: + + Pathway name + +- category: + + Pathway category + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_pathway_drugs.md b/docs/reference/drug_pathway_drugs.md new file mode 100644 index 0000000..67a8599 --- /dev/null +++ b/docs/reference/drug_pathway_drugs.md @@ -0,0 +1,13 @@ +# Drug Pathway Drugs parser + +Drugs involved in this pathway. + +## Usage + +``` r +drug_pathway_drugs() +``` + +## Value + +a tibble with pathway drugs properties diff --git a/docs/reference/drug_pathway_enzyme.md b/docs/reference/drug_pathway_enzyme.md new file mode 100644 index 0000000..38f91d8 --- /dev/null +++ b/docs/reference/drug_pathway_enzyme.md @@ -0,0 +1,13 @@ +# Drug Pathway Enzymes parser + +Enzymes involved in this pathway. + +## Usage + +``` r +drug_pathway_enzyme() +``` + +## Value + +a tibble with pathway properties diff --git a/docs/reference/drug_pdb_entries.md b/docs/reference/drug_pdb_entries.md new file mode 100644 index 0000000..4d5abbf --- /dev/null +++ b/docs/reference/drug_pdb_entries.md @@ -0,0 +1,19 @@ +# Drug pdb-entries parser + +Protein Data Bank (PDB) identifiers for this drug. + +## Usage + +``` r +drug_pdb_entries() +``` + +## Value + +a tibble with the following variables: + +- pdb-entry: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_pharmacology.md b/docs/reference/drug_pharmacology.md new file mode 100644 index 0000000..be4e1ca --- /dev/null +++ b/docs/reference/drug_pharmacology.md @@ -0,0 +1,94 @@ +# Drug Pharmacology parser + +Describes the use, mechanism of action, pharmacokinetics, +pharmacodynamics, and physiological or biochemical effects in the body. + +## Usage + +``` r +drug_pharmacology() +``` + +## Value + +a tibble with the following variables: + +- indication: + + The approved conditions, diseases, or states for which a drug can + safely and effectively be used. An indication is considered to be + FDA-approved when it has any of the following designations: NDA, ANDA, + BLA, or OTC. May also include indications in other countries, such as + Canada (through Health Canada) or in Europe (through the European + Medicines Agency). + +- pharmacodynamics: + + A description of how the drug modifies or affects the organism it is + being used in. May include effects in the body that are desired + (enzyme or protein targets for example) and undesired (also known as + “side effects”). This is in contrast to pharmacokinetics, which + describes how the body modifies the drug being used. + +- mechanism_of_action: + + A component of pharmacodynamics that describes the biochemical + interaction through which a drug produces its intended effect. May + include the exact molecular protein or enzyme targets and/or a + description of the physiological effects produced. + +- toxicity: + + Any adverse reaction, or side effect, that may or may not occur with + use of the drug. May be attributed to a number of effects including: + an enhanced therapeutic effect, rare anaphylactic reactions, + interactions with other medications, or unanticipated binding of the + molecule at different sites within the body. + +- metabolism: + + A description of the chemical degradation of the drug molecule within + the body; most commonly by enzymes from the Cytochrome P450 (CYP) + system in the liver. + +- absorption: + + A description of the movement of the drug from the site of + administration into the bloodstream or target tissue. Common + pharmacokinetic metrics used to evaluate absorption include Area Under + the Curve (AUC), bioavailability (F), maximum concentration (Cmax), + and time to maximum concentration (Tmax). + +- half-life: + + The period of time it takes for the amount of drug in the body to be + reduced by one half. Provides a description of how quickly the drug is + being eliminated and how much is available in the bloodstream. + +- protein-binding : + + A description of the drug’s affinity for plama proteins and the + proportion of the drug that is bound to them when in circulation + within the body. + +- route_of_elimination: + + A description of the pathway that is used to excrete the drug from the + body. Common pharmacokinetic parameters used to evaluate excretion + include elimination half life, renal clearance, and tracking of + radiolabelled compounds through the renal and GI system. + +- volume_of_distribution: + + The Vd of a drug represents the degree to which it is distributed into + body tissue compared to the plasma. + +- clearance: + + A pharmacokinetic measurement of the rate of removal of the drug from + plasma, expressed as mL/min; reflects the rate of elimination of the + drug. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_prices.md b/docs/reference/drug_prices.md new file mode 100644 index 0000000..e762aab --- /dev/null +++ b/docs/reference/drug_prices.md @@ -0,0 +1,29 @@ +# Drug Prices Parsers + +Unit drug prices + +## Usage + +``` r +drug_prices() +``` + +## Value + +a tibble with 5 variables: + +- description: + +- cost: + + Drug price per unit + +- currency: + + Currency of price, example: US. + +- unit: + +- parent_id: + + drugbank id diff --git a/docs/reference/drug_products.md b/docs/reference/drug_products.md new file mode 100644 index 0000000..f774036 --- /dev/null +++ b/docs/reference/drug_products.md @@ -0,0 +1,159 @@ +# Drug Products parser + +A list of commercially available products in Canada and the United +States that contain the drug. + +## Usage + +``` r +drug_products() +``` + +## Value + +a tibble with 32 variables: + +- name: + + The proprietary name(s) provided by the manufacturer for any + commercially available products containing this drug. + +- labeller: + + The corporation responsible for labelling this product. + +- ndc-id: + + The National Drug Code (NDC) identifier of the drug + +- ndc-product-code: + + The National Drug Code (NDC) product code from the FDA National Drug + Code directory. + +- dpd-id: + + Drug Product Database (DPD) identification number (a.k.a. DIN) from + the Canadian Drug Product Database. Only present for drugs that are + marketed in Canada + +- ema-product-code: + + EMA product code from the European Medicines Agency Database. Only + present for products that are authorized by central procedure for + marketing in the European Union. + +- ema-ma-number: + + EMA marketing authorization number from the European Medicines Agency + Database. Only present for products that are authorized by central + procedure for marketing in the European Union. + +- started-marketing-on: + + The starting date for market approval. + +- ended-marketing-on: + + The ending date for market approval. + +- dosage-form : + + The pharmaceutical formulation by which the drug is introduced into + the body. + +- strength: + + The amount of active drug ingredient provided in the dosage + +- route: + + The path by which the drug or product is taken into the body + +- fda-application-number: + + The New Drug Application \[NDA\] number assigned to this drug by the + FDA. + +- over-the-counter: + + A list of Over The Counter (OTC) forms of the drug. + +- generic: + + Whether this product is a generic drug. + +- approved: + + Indicates whether this drug has been approved by the regulating + government. + +- country: + + The country where this commercially available drug has been approved. + +- source: + + Source of this product information. For example, a value of DPD + indicates this information was retrieved from the Canadian Drug + Product Database. + +- standing: + + One of good, discordant, or deprecated. Distinguishes products with up + to date ingredient information (good) from products with conflicting + information (discordant) or products that have been removed from an + active label (deprecated). + +- standing-updated-on: + + The date on which the standing was last updated + +- standing-reason: + + Explains the non-good standing of the product. One of: + ingredient_change, code_duplication, invalid, or removed. + +- jurisdiction-marketing-category : + + The marketing category of this product in its jurisdiction + +- branded: + + Whether this product has a named brand + +- prescription: + + Whether this product is only available with a prescription + +- unapproved: + + Whether this product is not approved in its jurisdiction + +- vaccine: + + Whether this product is a vaccine + +- allergenic: + + Whether this product is used in allergenic testing + +- cosmetic: + + Whether this product is a cosmetic, such as sunscreen + +- kit: + + Whether this product is a kit composed of multiple distinct parts + +- solo: + + Whether this product has only a single active ingredient + +- available: + + Whether this product can be sold in its jurisdiction + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_reactions.md b/docs/reference/drug_reactions.md new file mode 100644 index 0000000..bf2a4ed --- /dev/null +++ b/docs/reference/drug_reactions.md @@ -0,0 +1,37 @@ +# Drug Reactions Parsers + +Extract the sequential representation of the metabolic reactions that +this drug molecule is involved in. Depending on available information, +this may include metabolizing enzymes, reaction type, substrates, +products, pharmacological activity of metabolites, and a structural +representation of the biochemical reactions. + +## Usage + +``` r +drug_reactions() +``` + +## Value + +a tibble with 5 variables: + +- sequence: + + Reactions are displayed within a numerical sequence + +- left_drugbank_name: + + The substrate of the reaction. Maybe a drug or a metabolite. + +- rightt_drugbank_name: + + The product of the reaction. Maybe a drug or a metabolite. + +- left_drugbank_id: + +- right_drugbank_id: + +- parent_id: + + drugbank id diff --git a/docs/reference/drug_reactions_enzymes.md b/docs/reference/drug_reactions_enzymes.md new file mode 100644 index 0000000..24ffe0d --- /dev/null +++ b/docs/reference/drug_reactions_enzymes.md @@ -0,0 +1,21 @@ +# Drug Reactions Enzymes Parsers + +Enzymes involved in metabolizing this drug + +## Usage + +``` r +drug_reactions_enzymes() +``` + +## Value + +a tibble with 3 variables: + +- name: + +- uniprot-id: + +- parent_id: + + drugbank id diff --git a/docs/reference/drug_salts.md b/docs/reference/drug_salts.md new file mode 100644 index 0000000..36921cd --- /dev/null +++ b/docs/reference/drug_salts.md @@ -0,0 +1,66 @@ +# Drug Salts parser + +Available salt forms of the drug. Ions such as hydrochloride, sodium, +and sulfate are often added to the drug molecule to increase solubility, +dissolution, or absorption. + +## Usage + +``` r +drug_salts() +``` + +## Value + +a tibble with 1 variables: + +- drugbank-id: + + DrugBank identifiers of the available salt form(s). + +- name: + + Name of the available salt form(s) + +- unii: + + Unique Ingredient Identifier (UNII) of the available salt form(s). + +- cas-number: + + Chemical Abstracts Service (CAS) registry number assigned to the salt + form(s) of the drug. + +- inchikey: + + IUPAC International Chemical Identifier (InChi) key identifier for the + available salt form(s). + +- average-mass: + + Average molecular mass: the weighted average of the isotopic masses of + the salt. + +- monoisotopic-mass: + + The mass of the most abundant isotope of the salt + +- smiles: + + The simplified molecular-input line-entry system (SMILES) is a line + notation used for describing the structure of chemical species using + short ASCII strings; calculated by ChemAxon. + +- inchi: + + A prediction of the IUPAC International Chemical Identifier (InChI); + imported by ChemAxon. + +- formula: + + Indicates the simple numbers of each type of atom within the molecule; + calculated by ChemAxon. + +- *drugbank_id*: + + parent drugbank id diff --git a/docs/reference/drug_sequences.md b/docs/reference/drug_sequences.md new file mode 100644 index 0000000..69ea730 --- /dev/null +++ b/docs/reference/drug_sequences.md @@ -0,0 +1,29 @@ +# Drug Sequences parser + +The amino acid sequence; provided if the drug is a peptide. + +## Usage + +``` r +drug_sequences() +``` + +## Value + +a tibble with the following variables: + +- sequence: + + a textual representation of the sequence + +- format: + + Currently, only the FASTA format is used + +- *drugbank_id*: + + drugbank id + +## Details + +Describes peptide sequences of biotech drugs diff --git a/docs/reference/drug_snp_adverse_reactions.md b/docs/reference/drug_snp_adverse_reactions.md new file mode 100644 index 0000000..0072815 --- /dev/null +++ b/docs/reference/drug_snp_adverse_reactions.md @@ -0,0 +1,47 @@ +# Drug SNP Adverse Drug Reactions parser + +The adverse drug reactions that may occur as a result of the listed +single nucleotide polymorphisms (SNPs) + +## Usage + +``` r +drug_snp_adverse_reactions() +``` + +## Value + +a tibble with the following variables: + +- protein-name: + + Proteins involved in this SNP. + +- gene-symbol: + + Genes involved in this SNP. + +- uniprot-id: + + Universal Protein Resource (UniProt) identifiers for proteins involved + in this pathway. + +- rs-id: + + The SNP Database identifier for this single nucleotide polymorphism. + +- allele: + + The alleles associated with the identified SNP. + +- adverse-reaction: + +- description: + +- pubmed-id : + + Reference to PubMed article. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_snp_effects.md b/docs/reference/drug_snp_effects.md new file mode 100644 index 0000000..158cf0f --- /dev/null +++ b/docs/reference/drug_snp_effects.md @@ -0,0 +1,51 @@ +# Drug SNP Effects parser + +A list of single nucleotide polymorphisms (SNPs) relevant to drug +activity or metabolism, and the effects these may have on +pharmacological activity. SNP effects in the patient may require close +monitoring, an increase or + +## Usage + +``` r +drug_snp_effects() +``` + +## Value + +a tibble with the following variables: + +- protein-name: + + Proteins involved in this SNP. + +- gene-symbol: + + Genes involved in this SNP. + +- uniprot-id: + + Universal Protein Resource (UniProt) identifiers for proteins involved + in this pathway. + +- rs-id: + + The SNP Database identifier for this single nucleotide polymorphism. + +- allele: + + The alleles associated with the identified SNP. + +- defining-change: + +- description: + + A written description of the SNP effects. + +- pubmed-id : + + Reference to PubMed article. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_syn.md b/docs/reference/drug_syn.md new file mode 100644 index 0000000..3016577 --- /dev/null +++ b/docs/reference/drug_syn.md @@ -0,0 +1,28 @@ +# Drug Synonyms parser + +Other names or identifiers that are associated with this drug. + +## Usage + +``` r +drug_syn() +``` + +## Value + +a tibble with 3 variables: + +- language: + + Names of the drug in languages other than English. + +- coder: + + Organization or source providing the synonym. For example, INN + indicates the synonym is an International Nonproprietary Name, while + IUPAC indicates the synonym is the nomenclature designated by the + International Union of Pure and Applied Chemistry. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drugs_articles.html b/docs/reference/drugs_articles.html new file mode 100644 index 0000000..b95e027 --- /dev/null +++ b/docs/reference/drugs_articles.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/drugs_attachments.html b/docs/reference/drugs_attachments.html new file mode 100644 index 0000000..2066a85 --- /dev/null +++ b/docs/reference/drugs_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/drugs_links.html b/docs/reference/drugs_links.html new file mode 100644 index 0000000..b768dff --- /dev/null +++ b/docs/reference/drugs_links.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/drugs_textbooks.html b/docs/reference/drugs_textbooks.html new file mode 100644 index 0000000..088dfba --- /dev/null +++ b/docs/reference/drugs_textbooks.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_attachments.html b/docs/reference/enzymes_attachments.html new file mode 100644 index 0000000..2066a85 --- /dev/null +++ b/docs/reference/enzymes_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypep_ex_ident.html b/docs/reference/enzymes_polypep_ex_ident.html new file mode 100644 index 0000000..7fd02f4 --- /dev/null +++ b/docs/reference/enzymes_polypep_ex_ident.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides.html b/docs/reference/enzymes_polypeptides.html new file mode 100644 index 0000000..554cbd6 --- /dev/null +++ b/docs/reference/enzymes_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides_go.html b/docs/reference/enzymes_polypeptides_go.html new file mode 100644 index 0000000..bda310f --- /dev/null +++ b/docs/reference/enzymes_polypeptides_go.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides_pfams.html b/docs/reference/enzymes_polypeptides_pfams.html new file mode 100644 index 0000000..cac389d --- /dev/null +++ b/docs/reference/enzymes_polypeptides_pfams.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides_syn.html b/docs/reference/enzymes_polypeptides_syn.html new file mode 100644 index 0000000..c0f768c --- /dev/null +++ b/docs/reference/enzymes_polypeptides_syn.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/find_dataframes_recursive.html b/docs/reference/find_dataframes_recursive.html new file mode 100644 index 0000000..41c3edf --- /dev/null +++ b/docs/reference/find_dataframes_recursive.html @@ -0,0 +1,86 @@ + +Find All Data Frames Recursively — find_dataframes_recursive • dbparser + Skip to contents + + +
    +
    +
    +

    Find All Data Frames Recursively

    + Source: R/dvobject_metadata.R +
    find_dataframes_recursive.Rd
    +
    + +
    +

    Find All Data Frames Recursively

    +
    + +
    +

    Usage

    + 
    find_dataframes_recursive(x, prefix = "")
    +
    + +
    +

    Arguments

    + + +
    x
    +

    Object to search

    + + +
    prefix
    +

    Current path prefix

    + +
    +
    +

    Value

    +

    Data.frame with paths, dimensions, and sizes

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/find_dataframes_recursive.md b/docs/reference/find_dataframes_recursive.md new file mode 100644 index 0000000..fac0d56 --- /dev/null +++ b/docs/reference/find_dataframes_recursive.md @@ -0,0 +1,23 @@ +# Find All Data Frames Recursively + +Find All Data Frames Recursively + +## Usage + +``` r +find_dataframes_recursive(x, prefix = "") +``` + +## Arguments + +- x: + + Object to search + +- prefix: + + Current path prefix + +## Value + +Data.frame with paths, dimensions, and sizes diff --git a/docs/reference/find_second_database.html b/docs/reference/find_second_database.html new file mode 100644 index 0000000..96ad640 --- /dev/null +++ b/docs/reference/find_second_database.html @@ -0,0 +1,82 @@ + +Find Second Database in Attributes — find_second_database • dbparser + Skip to contents + + +
    +
    +
    +

    Find Second Database in Attributes

    + Source: R/dvobject_metadata.R +
    find_second_database.Rd
    +
    + +
    +

    Find Second Database in Attributes

    +
    + +
    +

    Usage

    + 
    find_second_database(attrs)
    +
    + +
    +

    Arguments

    + + +
    attrs
    +

    Attributes list

    + +
    +
    +

    Value

    +

    List with has_second_db (logical) and second_db_name (character)

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/find_second_database.md b/docs/reference/find_second_database.md new file mode 100644 index 0000000..5609df0 --- /dev/null +++ b/docs/reference/find_second_database.md @@ -0,0 +1,19 @@ +# Find Second Database in Attributes + +Find Second Database in Attributes + +## Usage + +``` r +find_second_database(attrs) +``` + +## Arguments + +- attrs: + + Attributes list + +## Value + +List with has_second_db (logical) and second_db_name (character) diff --git a/docs/reference/index.md b/docs/reference/index.md new file mode 100644 index 0000000..fc0592d --- /dev/null +++ b/docs/reference/index.md @@ -0,0 +1,43 @@ +# Package index + +## Drugs Databases Parser + +Parse public drug databases and converted them into dvobject + +- [`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md) + : returns carriers, enzymes,targets and transporters node valid + options. +- [`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md) + : returns drug node valid options. +- [`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md) + : parseDrugBank +- [`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md) + : Parse the OnSIDES Core Relational Database +- [`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) + : Parse the TWOSIDES Drug-Drug Interaction Database +- [`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) + : returns references node valid options. + +## Utility functions + +Different functions to handle dvobject + +- [`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md) + : add_database_info Assign passed databases db metadata to passed + dvobject +- [`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md) + : Display dvobject Metadata +- [`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md) + : Subset a DrugBank dvobject by a vector of DrugBank IDs +- [`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) + : Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs + (Schema-Aware) + +## Merge functions + +Different functions to merge different types of dvobjects + +- [`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md) + : Merge DrugBank and OnSIDES Database Objects +- [`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md) + : Merge a DrugBank dvobject with a TWOSIDES dvobject diff --git a/docs/reference/init_dvobject.md b/docs/reference/init_dvobject.md new file mode 100644 index 0000000..c588412 --- /dev/null +++ b/docs/reference/init_dvobject.md @@ -0,0 +1,13 @@ +# init_dvobject initialize dvobject + +init_dvobject initialize dvobject + +## Usage + +``` r +init_dvobject() +``` + +## Value + +dvobject diff --git a/docs/reference/links.md b/docs/reference/links.md new file mode 100644 index 0000000..7284c8b --- /dev/null +++ b/docs/reference/links.md @@ -0,0 +1,38 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser + +Return a list of websites that were used as references for Drugs/ +Carriers/ Enzymes/ Targets/ Transporters + +## Usage + +``` r +drugs_links() + +carriers_links() + +enzymes_links() + +targets_links() + +transporters_links() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Name of the source website + +- title: + + Identifier for this drug in the given resource + +- url: + + The url of the website + +- *parent_id*: + + drug/ carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/merge_drugbank_onsides.html b/docs/reference/merge_drugbank_onsides.html new file mode 100644 index 0000000..5db51dd --- /dev/null +++ b/docs/reference/merge_drugbank_onsides.html @@ -0,0 +1,141 @@ + +Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides • dbparser + Skip to contents + + +
    +
    +
    +

    Merge DrugBank and OnSIDES Database Objects

    + Source: R/merge_helpers.R +
    merge_drugbank_onsides.Rd
    +
    + +
    +

    Creates an integrated dvobject object by linking DrugBank dvobject with +OnSIDES dvobject using RxNorm CUIs as the bridge.

    +
    + +
    +

    Usage

    + 
    merge_drugbank_onsides(db_object, onsides_db)
    +
    + +
    +

    Arguments

    + + +
    db_object
    +

    A dvobject from `parseDrugBank()` OR an existing merged +dvobject (containing `$drugbank`).

    + + +
    onsides_db
    +

    A dvobject produced by `dbparser::parseOnSIDES()`.

    + +
    +
    +

    Value

    +

    A new dvobject containing the integrated data.

    +
    +
    +

    Details

    +

    This function performs the following key steps: +1. Creates a mapping table between DrugBank IDs and RxNorm CUIs from the DrugBank object. +2. Enriches the relevant OnSIDES tables (`vocab_rxnorm_ingredient` and optionally + `high_confidence`) by adding a `drugbank_id` column. +3. Assembles a new list object containing all original tables plus the enriched ones + and the ID mapping table itself.

    +

    The resulting object allows for powerful queries that span both mechanistic data from +DrugBank and clinical side-effect data from OnSIDES. +Supports piping and chaining with other merge functions.

    +
    +
    +

    See also

    +

    Other mergers: +merge_drugbank_twosides()

    +
    + +
    +

    Examples

    + 
    if (FALSE) { # \dontrun{
+# First, parse the individual databases
+drugbank <- parseDrugBank("path/to/drugbank.xml")
+onsides <- parseOnSIDES("path/to/onsides_csvs/")
+
+# Now, merge them into a single, powerful object
+merged_db <- merge_drugbank_onsides(drugbank, onsides)
+
+# --- Example Analysis: Find the protein targets of all drugs known to ---
+# --- cause the side effect "Hepatitis" with high confidence.        ---
+
+# 1. Find the MedDRA ID for "Hepatitis"
+hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>%
+  filter(meddra_name == "Hepatitis") %>%
+  pull(meddra_id)
+
+# 2. Find all drug ingredients linked to this effect in the high_confidence table
+drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>%
+  filter(effect_meddra_id == hepatitis_id) %>%
+  pull(drugbank_id) %>%
+  na.omit() %>%
+  unique()
+
+# 3. Look up the targets for these DrugBank IDs
+targets_of_interest <- merged_db$targets %>%
+  filter(parent_key %in% drug_ids_causing_hepatitis) %>%
+  select(drug_id = parent_key, target_name = name, gene_name)
+
+head(targets_of_interest)
+} # }
+
    +
    +
    + + +
    + + + + + + + diff --git a/docs/reference/merge_drugbank_onsides.md b/docs/reference/merge_drugbank_onsides.md new file mode 100644 index 0000000..cde6876 --- /dev/null +++ b/docs/reference/merge_drugbank_onsides.md @@ -0,0 +1,78 @@ +# Merge DrugBank and OnSIDES Database Objects + +Creates an integrated dvobject object by linking DrugBank dvobject with +OnSIDES dvobject using RxNorm CUIs as the bridge. + +## Usage + +``` r +merge_drugbank_onsides(db_object, onsides_db) +``` + +## Arguments + +- db_object: + + A dvobject from \`parseDrugBank()\` OR an existing merged dvobject + (containing \`\$drugbank\`). + +- onsides_db: + + A dvobject produced by \`dbparser::parseOnSIDES()\`. + +## Value + +A new dvobject containing the integrated data. + +## Details + +This function performs the following key steps: 1. Creates a mapping +table between DrugBank IDs and RxNorm CUIs from the DrugBank object. 2. +Enriches the relevant OnSIDES tables (\`vocab_rxnorm_ingredient\` and +optionally \`high_confidence\`) by adding a \`drugbank_id\` column. 3. +Assembles a new list object containing all original tables plus the +enriched ones and the ID mapping table itself. + +The resulting object allows for powerful queries that span both +mechanistic data from DrugBank and clinical side-effect data from +OnSIDES. Supports piping and chaining with other merge functions. + +## See also + +Other mergers: +[`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md) + +## Examples + +``` r +if (FALSE) { # \dontrun{ +# First, parse the individual databases +drugbank <- parseDrugBank("path/to/drugbank.xml") +onsides <- parseOnSIDES("path/to/onsides_csvs/") + +# Now, merge them into a single, powerful object +merged_db <- merge_drugbank_onsides(drugbank, onsides) + +# --- Example Analysis: Find the protein targets of all drugs known to --- +# --- cause the side effect "Hepatitis" with high confidence. --- + +# 1. Find the MedDRA ID for "Hepatitis" +hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% + filter(meddra_name == "Hepatitis") %>% + pull(meddra_id) + +# 2. Find all drug ingredients linked to this effect in the high_confidence table +drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% + filter(effect_meddra_id == hepatitis_id) %>% + pull(drugbank_id) %>% + na.omit() %>% + unique() + +# 3. Look up the targets for these DrugBank IDs +targets_of_interest <- merged_db$targets %>% + filter(parent_key %in% drug_ids_causing_hepatitis) %>% + select(drug_id = parent_key, target_name = name, gene_name) + +head(targets_of_interest) +} # } +``` diff --git a/docs/reference/merge_drugbank_twosides.html b/docs/reference/merge_drugbank_twosides.html new file mode 100644 index 0000000..ff755a6 --- /dev/null +++ b/docs/reference/merge_drugbank_twosides.html @@ -0,0 +1,97 @@ + +Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides • dbparser + Skip to contents + + +
    +
    +
    +

    Merge a DrugBank dvobject with a TWOSIDES dvobject

    + Source: R/merge_helpers.R +
    merge_drugbank_twosides.Rd
    +
    + +
    +

    Integrates drug-drug interaction data from TWOSIDES with the rich mechanistic +information from DrugBank. This function is chainable and can accept a raw +DrugBank object or an already-merged dvobject.

    +
    + +
    +

    Usage

    + 
    merge_drugbank_twosides(db_object, twosides_db)
    +
    + +
    +

    Arguments

    + + +
    db_object
    +

    A dvobject from `parseDrugBank()` or an existing merged dvobject.

    + + +
    twosides_db
    +

    A dvobject from `parseTWOSIDES()`.

    + +
    +
    +

    Value

    +

    A new, nested dvobject with the TWOSIDES data added.

    +
    +
    +

    See also

    +

    Other mergers: +merge_drugbank_onsides()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/merge_drugbank_twosides.md b/docs/reference/merge_drugbank_twosides.md new file mode 100644 index 0000000..dc42896 --- /dev/null +++ b/docs/reference/merge_drugbank_twosides.md @@ -0,0 +1,30 @@ +# Merge a DrugBank dvobject with a TWOSIDES dvobject + +Integrates drug-drug interaction data from TWOSIDES with the rich +mechanistic information from DrugBank. This function is chainable and +can accept a raw DrugBank object or an already-merged dvobject. + +## Usage + +``` r +merge_drugbank_twosides(db_object, twosides_db) +``` + +## Arguments + +- db_object: + + A dvobject from \`parseDrugBank()\` or an existing merged dvobject. + +- twosides_db: + + A dvobject from \`parseTWOSIDES()\`. + +## Value + +A new, nested dvobject with the TWOSIDES data added. + +## See also + +Other mergers: +[`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md) diff --git a/docs/reference/parseDrugBank.md b/docs/reference/parseDrugBank.md new file mode 100644 index 0000000..36c6f46 --- /dev/null +++ b/docs/reference/parseDrugBank.md @@ -0,0 +1,67 @@ +# parseDrugBank + +parses given DrugBank XML database into a dvobject. dvobject is a list +of data.frames in which each data.frame represents a part of parsed data +(i.e drugs, prices, carriers, ...) + +## Usage + +``` r +parseDrugBank( + db_path, + drug_options = NULL, + parse_salts = FALSE, + parse_products = FALSE, + references_options = NULL, + cett_options = NULL +) +``` + +## Arguments + +- db_path: + + **string**, full path for the **DrugBank** xml or zip file. + +- drug_options: + + **character vector**, list of sub drug related nodes names options to + parse (default = NULL). Check + [`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md) + for all available options. If its value is \`NULL\` ONLY + \`drug_general_information\` will be placed in the returned dvobject. + +- parse_salts: + + **boolean**, parse salts info (default = FALSE) + +- parse_products: + + **boolean**, parse products info (default = FALSE) + +- references_options: + + **character vector**, list of sub references related nodes names + options to parse (default = NULL). Check + [`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) + for all available options. + +- cett_options: + + **character vector**, list of sub cett related nodes names options to + parse (default = NULL). Check + [`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md) + for all available options. + +## Value + +dvobject + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/parseOnSIDES.html b/docs/reference/parseOnSIDES.html new file mode 100644 index 0000000..d0c927c --- /dev/null +++ b/docs/reference/parseOnSIDES.html @@ -0,0 +1,118 @@ + +Parse the OnSIDES Core Relational Database — parseOnSIDES • dbparser + Skip to contents + + +
    +
    +
    +

    Parse the OnSIDES Core Relational Database

    + Source: R/onsides_parser.R +
    parseOnSIDES.Rd
    +
    + +
    +

    Parses the core relational tables from the OnSIDES database.

    +
    + +
    +

    Usage

    + 
    parseOnSIDES(
+  dataDir,
+  include_high_confidence = TRUE,
+  db_version = NULL,
+  db_exported_date = NULL
+)
    +
    + +
    +

    Arguments

    + + +
    dataDir
    +

    A string specifying the path to the directory containing the +OnSIDES CSV files.

    + + +
    include_high_confidence
    +

    Logical. If TRUE (the default), the function +will also parse the `high_confidence.csv` file, which is a pre-aggregated +summary of ingredient-to-effect relationships. If the file is not found, +a warning is issued.

    + + +
    db_version
    +

    used onside version (default = NULL)

    + + +
    db_exported_date
    +

    used onside release date (default = NULL)

    + +
    +
    +

    Value

    +

    dvobject

    +
    +
    +

    See also

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseTWOSIDES(), +references_node_options()

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseTWOSIDES(), +references_node_options()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/parseOnSIDES.md b/docs/reference/parseOnSIDES.md new file mode 100644 index 0000000..12ac995 --- /dev/null +++ b/docs/reference/parseOnSIDES.md @@ -0,0 +1,56 @@ +# Parse the OnSIDES Core Relational Database + +Parses the core relational tables from the OnSIDES database. + +## Usage + +``` r +parseOnSIDES( + dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL +) +``` + +## Arguments + +- dataDir: + + A string specifying the path to the directory containing the OnSIDES + CSV files. + +- include_high_confidence: + + Logical. If TRUE (the default), the function will also parse the + \`high_confidence.csv\` file, which is a pre-aggregated summary of + ingredient-to-effect relationships. If the file is not found, a + warning is issued. + +- db_version: + + used onside version (default = NULL) + +- db_exported_date: + + used onside release date (default = NULL) + +## Value + +dvobject + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/parseTWOSIDES.html b/docs/reference/parseTWOSIDES.html new file mode 100644 index 0000000..39ea744 --- /dev/null +++ b/docs/reference/parseTWOSIDES.html @@ -0,0 +1,149 @@ + +Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES • dbparser + Skip to contents + + +
    +
    +
    +

    Parse the TWOSIDES Drug-Drug Interaction Database

    + Source: R/nsides_parsers.R +
    parseTWOSIDES.Rd
    +
    + +
    +

    Reads the TWOSIDES data file, which contains adverse event data for pairs of +drugs taken concurrently (N=2 interactions).

    +
    + +
    +

    Usage

    + 
    parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL)
    +
    + +
    +

    Arguments

    + + +
    twosides_file_path
    +

    Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz').

    + + +
    db_version
    +

    used twoside version (default = NULL)

    + + +
    db_exported_date
    +

    used twoside release date (default = NULL)

    + +
    +
    +

    Value

    +

    A dvobject of class `TWOSIDESDB` containing the `drug_drug_interactions` + data frame and associated metadata.

    +
    +
    +

    Details

    +

    TWOSIDES is a database of drug-drug interaction safety signals +mined from the FDA's Adverse Event Reporting System using the same +approach as is used to generate OffSIDES.

    +

    Database fields as follow:

    drug_1_rxnorn_id
    +

    RxNORM identifier for drug 1

    + +
    drug_1_concept_name
    +

    RxNORM name string for drug 1

    + +
    drug_2_rxnorm_id
    +

    RxNORM identifier for drug 2

    + +
    drug_2_concept_name
    +

    RxNORM name string for drug 3

    + +
    condition_meddra_id
    +

    MedDRA identifier for the side effect

    + +
    condition_concpet_name
    +

    MedDRA name string for the side effect

    + +
    A
    +

    The number of reports for the pair of drugs that report the side effect

    + +
    B
    +

    The number of reports for the pair of drugs that do not report the side effect

    + +
    C
    +

    The number of reports for other PSM matched drugs (including perhaps the single versions of drug 1 or drug 2) that report the side effect

    + +
    D
    +

    The number of reports for other PSM matched drugs and other side effects

    + +
    PRR
    +

    Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D))

    + +
    PRR_error
    +

    Error estimate of the PRR

    + +
    mean_reporting_frequency
    +

    Proportion of reports for the drug that report the side effect, A/(A+B)

    + + +
    +
    +

    See also

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseOnSIDES(), +references_node_options()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/parseTWOSIDES.md b/docs/reference/parseTWOSIDES.md new file mode 100644 index 0000000..87f87ab --- /dev/null +++ b/docs/reference/parseTWOSIDES.md @@ -0,0 +1,106 @@ +# Parse the TWOSIDES Drug-Drug Interaction Database + +Reads the +[TWOSIDES](https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz) +data file, which contains adverse event data for pairs of drugs taken +concurrently (N=2 interactions). + +## Usage + +``` r +parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL) +``` + +## Arguments + +- twosides_file_path: + + Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). + +- db_version: + + used twoside version (default = NULL) + +- db_exported_date: + + used twoside release date (default = NULL) + +## Value + +A dvobject of class \`TWOSIDESDB\` containing the +\`drug_drug_interactions\` data frame and associated metadata. + +## Details + +[TWOSIDES](https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz) +is a database of drug-drug interaction safety signals mined from the +FDA's Adverse Event Reporting System using the same approach as is used +to generate OffSIDES. + +Database fields as follow: + +- drug_1_rxnorn_id: + + RxNORM identifier for drug 1 + +- drug_1_concept_name: + + RxNORM name string for drug 1 + +- drug_2_rxnorm_id: + + RxNORM identifier for drug 2 + +- drug_2_concept_name: + + RxNORM name string for drug 3 + +- condition_meddra_id: + + MedDRA identifier for the side effect + +- condition_concpet_name: + + MedDRA name string for the side effect + +- A: + + The number of reports for the pair of drugs that report the side + effect + +- B: + + The number of reports for the pair of drugs that do not report the + side effect + +- C: + + The number of reports for other PSM matched drugs (including perhaps + the single versions of drug 1 or drug 2) that report the side effect + +- D: + + The number of reports for other PSM matched drugs and other side + effects + +- PRR: + + Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D)) + +- PRR_error: + + Error estimate of the PRR + +- mean_reporting_frequency: + + Proportion of reports for the drug that report the side effect, + A/(A+B) + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/parse_cett_node.md b/docs/reference/parse_cett_node.md new file mode 100644 index 0000000..e18acb8 --- /dev/null +++ b/docs/reference/parse_cett_node.md @@ -0,0 +1,14 @@ +# Run all CETT related parsers + +Run all parsers that retrieve carriers, enzymes, targets and +transporters related information + +## Usage + +``` r +parse_cett_node(cett_options) +``` + +## Value + +a list of all drugs parsed tibbles diff --git a/docs/reference/parse_drug_nodes.md b/docs/reference/parse_drug_nodes.md new file mode 100644 index 0000000..0e8a5cc --- /dev/null +++ b/docs/reference/parse_drug_nodes.md @@ -0,0 +1,19 @@ +# Run all drug related parsers + +Run all parsers that retrieve drugs related information + +## Usage + +``` r +parse_drug_nodes(drug_options) +``` + +## Arguments + +- drug_options: + + \- list of options to parse + +## Value + +a list of all drugs parsed tibbles diff --git a/docs/reference/parse_references_node.md b/docs/reference/parse_references_node.md new file mode 100644 index 0000000..64aa2ec --- /dev/null +++ b/docs/reference/parse_references_node.md @@ -0,0 +1,15 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser + +Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element +parser + +## Usage + +``` r +parse_references_node(references_options) +``` + +## Value + +a list of all references for drugs, carriers, enzymes, targets or +transporters diff --git a/docs/reference/read_drugbank_xml_db.md b/docs/reference/read_drugbank_xml_db.md new file mode 100644 index 0000000..51cc467 --- /dev/null +++ b/docs/reference/read_drugbank_xml_db.md @@ -0,0 +1,29 @@ +# Reads **DrugBank** xml database and load it into memory. + +`read_drugbank_xml_db` loads **DrugBank** xml database full tree into +memory. + +## Usage + +``` r +read_drugbank_xml_db(db_path) +``` + +## Arguments + +- db_path: + + **string**, full path for the **DrugBank** xml or zip file. + +## Value + +loaded DB or NULL + +## Details + +This functions reads **DrugBank** xml database and load it into memory +for later processing. Hence; this method **must** be called before any +other function in the package and it needs to be called one time only. + +It takes one single mandatory argument which is the location of DrugBank +db. diff --git a/docs/reference/references_node_options.md b/docs/reference/references_node_options.md new file mode 100644 index 0000000..97f0908 --- /dev/null +++ b/docs/reference/references_node_options.md @@ -0,0 +1,22 @@ +# returns references node valid options. + +returns references node valid options. + +## Usage + +``` r +references_node_options() +``` + +## Value + +list of references valid options + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) diff --git a/docs/reference/show_dvobject_metadata.md b/docs/reference/show_dvobject_metadata.md new file mode 100644 index 0000000..58081be --- /dev/null +++ b/docs/reference/show_dvobject_metadata.md @@ -0,0 +1,41 @@ +# Display dvobject Metadata + +Displays information about passed dbobject object including basic info, +database metadata, and all data.frames contained within nested lists. + +## Usage + +``` r +show_dvobject_metadata(obj, return_df = FALSE) +``` + +## Arguments + +- obj: + + A dvobject + +- return_df: + + Logical. If TRUE, returns metadata data.frame without printing. + Default is FALSE. + +## Value + +Invisibly returns a data.frame containing dvobject metadata + +## See also + +Other utility: +[`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md), +[`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md), +[`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) + +## Examples + +``` r +if (FALSE) { # \dontrun{ +display_merged_db_attrs(drugbank) +metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) +} # } +``` diff --git a/docs/reference/subset_drugbank_dvobject.html b/docs/reference/subset_drugbank_dvobject.html new file mode 100644 index 0000000..6d0b5fa --- /dev/null +++ b/docs/reference/subset_drugbank_dvobject.html @@ -0,0 +1,109 @@ + +Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject • dbparser + Skip to contents + + +
    +
    +
    +

    Subset a DrugBank dvobject by a vector of DrugBank IDs

    + Source: R/utils.R +
    subset_drugbank_dvobject.Rd
    +
    + +
    +

    Subset a DrugBank dvobject by a vector of DrugBank IDs

    +
    + +
    +

    Usage

    + 
    subset_drugbank_dvobject(dvobject, drug_ids)
    +
    + +
    +

    Arguments

    + + +
    dvobject
    +

    The dvobject from `parseDrugBank()`.

    + + +
    drug_ids
    +

    A character vector of `drugbank_id` values to keep.

    + +
    +
    +

    Value

    +

    A new, smaller dvobject with the same structure and attributes.

    +
    +
    +

    Details

    +

    Intelligently filters a DrugBank dvobject to retain only the data associated +with a specified list of drugbank_ids. It correctly handles the deep, +multi-level nested structure of the entire object, including the complex +relationships within the `cett` list.

    +
    +
    +

    See also

    +

    Other utility: +add_database_info(), +show_dvobject_metadata(), +subset_onsides_dvobject()

    +
    + +
    +

    Examples

    + 
    if (FALSE) { # \dontrun{
+library(dbparser)
+one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank,
+                                     drug_ids = "DB00001")
+} # }
+
    +
    +
    + + +
    + + + + + + + diff --git a/docs/reference/subset_drugbank_dvobject.md b/docs/reference/subset_drugbank_dvobject.md new file mode 100644 index 0000000..7e6b240 --- /dev/null +++ b/docs/reference/subset_drugbank_dvobject.md @@ -0,0 +1,47 @@ +# Subset a DrugBank dvobject by a vector of DrugBank IDs + +Subset a DrugBank dvobject by a vector of DrugBank IDs + +## Usage + +``` r +subset_drugbank_dvobject(dvobject, drug_ids) +``` + +## Arguments + +- dvobject: + + The dvobject from \`parseDrugBank()\`. + +- drug_ids: + + A character vector of \`drugbank_id\` values to keep. + +## Value + +A new, smaller dvobject with the same structure and attributes. + +## Details + +Intelligently filters a DrugBank dvobject to retain only the data +associated with a specified list of drugbank_ids. It correctly handles +the deep, multi-level nested structure of the entire object, including +the complex relationships within the \`cett\` list. + +## See also + +Other utility: +[`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md), +[`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md), +[`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) + +## Examples + +``` r +if (FALSE) { # \dontrun{ +library(dbparser) +one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, + drug_ids = "DB00001") +} # } +``` diff --git a/docs/reference/subset_onsides_dvobject.html b/docs/reference/subset_onsides_dvobject.html new file mode 100644 index 0000000..0a0d96f --- /dev/null +++ b/docs/reference/subset_onsides_dvobject.html @@ -0,0 +1,96 @@ + +Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject • dbparser + Skip to contents + + +
    +
    +
    +

    Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware)

    + Source: R/utils.R +
    subset_onsides_dvobject.Rd
    +
    + +
    +

    Intelligently filters an OnSIDES dvobject by cascading filters through the +relational tables, ensuring the final subset is self-consistent.

    +
    + +
    +

    Usage

    + 
    subset_onsides_dvobject(dvobject, ingredient_ids)
    +
    + +
    +

    Arguments

    + + +
    dvobject
    +

    A dvobject from `parseOnSIDES()`.

    + + +
    ingredient_ids
    +

    A character vector of RxNorm CUIs (ingredients) to keep.

    + +
    +
    +

    Value

    +

    A new, smaller dvobject with the same structure.

    +
    +
    +

    See also

    +

    Other utility: +add_database_info(), +show_dvobject_metadata(), +subset_drugbank_dvobject()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/subset_onsides_dvobject.md b/docs/reference/subset_onsides_dvobject.md new file mode 100644 index 0000000..524fe7b --- /dev/null +++ b/docs/reference/subset_onsides_dvobject.md @@ -0,0 +1,31 @@ +# Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) + +Intelligently filters an OnSIDES dvobject by cascading filters through +the relational tables, ensuring the final subset is self-consistent. + +## Usage + +``` r +subset_onsides_dvobject(dvobject, ingredient_ids) +``` + +## Arguments + +- dvobject: + + A dvobject from \`parseOnSIDES()\`. + +- ingredient_ids: + + A character vector of RxNorm CUIs (ingredients) to keep. + +## Value + +A new, smaller dvobject with the same structure. + +## See also + +Other utility: +[`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md), +[`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md), +[`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md) diff --git a/docs/reference/targets_attachments.html b/docs/reference/targets_attachments.html new file mode 100644 index 0000000..2066a85 --- /dev/null +++ b/docs/reference/targets_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypep_ex_ident.html b/docs/reference/targets_polypep_ex_ident.html new file mode 100644 index 0000000..7fd02f4 --- /dev/null +++ b/docs/reference/targets_polypep_ex_ident.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides.html b/docs/reference/targets_polypeptides.html new file mode 100644 index 0000000..554cbd6 --- /dev/null +++ b/docs/reference/targets_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides_go.html b/docs/reference/targets_polypeptides_go.html new file mode 100644 index 0000000..bda310f --- /dev/null +++ b/docs/reference/targets_polypeptides_go.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides_pfams.html b/docs/reference/targets_polypeptides_pfams.html new file mode 100644 index 0000000..cac389d --- /dev/null +++ b/docs/reference/targets_polypeptides_pfams.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides_syn.html b/docs/reference/targets_polypeptides_syn.html new file mode 100644 index 0000000..c0f768c --- /dev/null +++ b/docs/reference/targets_polypeptides_syn.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_attachments.html b/docs/reference/transporters_attachments.html new file mode 100644 index 0000000..2066a85 --- /dev/null +++ b/docs/reference/transporters_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_polypeptides.html b/docs/reference/transporters_polypeptides.html new file mode 100644 index 0000000..554cbd6 --- /dev/null +++ b/docs/reference/transporters_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_polypeptides_go.html b/docs/reference/transporters_polypeptides_go.html new file mode 100644 index 0000000..bda310f --- /dev/null +++ b/docs/reference/transporters_polypeptides_go.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_polypeptides_pfams.html b/docs/reference/transporters_polypeptides_pfams.html new file mode 100644 index 0000000..cac389d --- /dev/null +++ b/docs/reference/transporters_polypeptides_pfams.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_polypeptides_syn.html b/docs/reference/transporters_polypeptides_syn.html new file mode 100644 index 0000000..c0f768c --- /dev/null +++ b/docs/reference/transporters_polypeptides_syn.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/search.json b/docs/search.json new file mode 100644 index 0000000..1b0ac62 --- /dev/null +++ b/docs/search.json @@ -0,0 +1 @@ +[{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"DrugBank database global gold standard drug information, containing rich data chemical structures, pharmacology, molecular targets. However, raw data provided massive, complex XML file difficult use statistical analysis. dbparser solves problem. transforms complex XML Drugverse Object (dvobject)—structured collection R data frames ready analysis. tutorial, demonstrate : Parse database. Explore data structure. Visualize key insights using dplyr canvasXpress.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"the-parsing-workflow","dir":"Articles","previous_headings":"1. Loading Data","what":"The Parsing Workflow","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"real-world scenario, parse full XML database (downloaded DrugBank) using parseDrugBank().","code":"library(dbparser) # Parse the full XML file (this creates a dvobject) # drugbank_db <- parseDrugBank(\"drugbank_full_database.xml\")"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"loading-sample-data","dir":"Articles","previous_headings":"1. Loading Data","what":"Loading Sample Data","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"vignette, load curated sample datasets included package. represent specific tables found inside full dvobject.","code":"suppressPackageStartupMessages({ library(tidyr) library(dplyr) library(tibble) library(canvasXpress) library(dbparser) }) # Load sample tables representing parts of the parsed dvobject drugs <- readRDS(system.file(\"drugs.RDS\", package = \"dbparser\")) drug_groups <- readRDS(system.file(\"drug_groups.RDS\", package = \"dbparser\")) drug_targets_actions <- readRDS(system.file(\"targets_actions.RDS\", package = \"dbparser\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-the-drug-landscape","dir":"Articles","previous_headings":"","what":"2. Analysis: The Drug Landscape","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"universe approved drugs look like? Let’s analyze composition database drug type (Small Molecule vs. Biotech).","code":"# Prepare data: Count drugs by type type_stat <- drugs %>% group_by(type) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% column_to_rownames(\"type\") # Visualize canvasXpress( data = type_stat, graphType = \"Bar\", title = \"Composition of DrugBank: Drug Types\", showSampleNames = FALSE, legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-approval-status","dir":"Articles","previous_headings":"","what":"3. Analysis: Approval Status","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Drugs categorized groups “approved”, “investigational”, “experimental”. complexity (Biotech vs. Small Molecule) differ across groups?","code":"# Prepare data: Cross-tabulate Type vs Group group_stat <- drugs %>% full_join(drug_groups, by = \"drugbank_id\") %>% group_by(type, group) %>% summarise(count = n(), .groups = 'drop') %>% pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% column_to_rownames(\"type\") # Visualize with a Stacked Bar Chart canvasXpress( data = group_stat, graphType = \"Stacked\", graphOrientation = \"horizontal\", title = \"Drug Types by Approval Status\", xAxisTitle = \"Number of Drugs\", legendPosition = \"bottom\", xAxis2Show = FALSE )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-molecular-mechanisms","dir":"Articles","previous_headings":"","what":"4. Analysis: Molecular Mechanisms","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"One DrugBank’s valuable features detailed information drugs interact targets (Proteins, Enzymes, etc.). drugs mostly inhibitors, agonists, antagonists?","code":"# Prepare data: Top 10 most common Mechanisms of Action targetActionCounts <- drug_targets_actions %>% group_by(action) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% slice_head(n = 10) %>% column_to_rownames(\"action\") # Visualize canvasXpress( data = targetActionCounts, graphType = \"Bar\", graphOrientation = \"vertical\", colorBy = \"Count\", title = \"Top 10 Mechanisms of Action\", xAxisTitle = \"Number of Interactions\", showSampleNames = FALSE, legendPosition = \"none\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"next-steps-integrated-pharmacovigilance","dir":"Articles","previous_headings":"","what":"5. Next Steps: Integrated Pharmacovigilance","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Now mastered mechanistic data DrugBank, can combine real-world data! dbparser now supports OnSIDES (Adverse Events) TWOSIDES (Drug-Drug Interactions). Check Integrated Pharmacovigilance Vignette learn merge databases perform polypharmacy risk analysis.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"the-hub-and-spoke-architecture","dir":"Articles","previous_headings":"","what":"The “Hub and Spoke” Architecture","title":"Introducing dbparser 2.2.0","text":"Version 2.2.0 moves beyond simple XML parsing. re-engineered package around “Hub Spoke” integration model: Hub: DrugBank serves anchor, providing stable molecular definitions. Spokes: OnSIDES TWOSIDES provide phenotypic clinical layers. introduced specific functions bridge worlds. new merge_drugbank_onsides() merge_drugbank_twosides() functions don’t just combine lists; perform intelligent “double joins” ID mapping (using RxNorm CUIs) ensure molecular data correctly linked clinical outcomes.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"pipeline-ready-pharmacovigilance","dir":"Articles","previous_headings":"","what":"Pipeline-Ready Pharmacovigilance","title":"Introducing dbparser 2.2.0","text":"One main design goals usability. new merge functions “chainable,” meaning integrate seamlessly tidyverse. can now build massive, multi-domain pharmacovigilance dataset three lines R code: result unified dvobject (DrugVerse Object) contains mechanistic data, label data, interaction data, enriched common identifiers.","code":"library(dbparser) library(dplyr) final_db <- parseDrugBank(\"data/drugbank.xml\") %>% merge_drugbank_onsides(parseOnSIDES(\"data/onsides/\")) %>% merge_drugbank_twosides(parseTWOSIDES(\"data/twosides.csv.gz\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"new-tools-for-reproducibility","dir":"Articles","previous_headings":"","what":"New Tools for Reproducibility","title":"Introducing dbparser 2.2.0","text":"support developers educators, also exposed internal subsetting engines (subset_drugbank_dvobject subset_onsides_dvobject). schema-aware functions allow slice massive databases consistent, shareable micro-datasets—perfect creating unit tests teaching materials.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"a-scientific-case-study","dir":"Articles","previous_headings":"","what":"A Scientific Case Study","title":"Introducing dbparser 2.2.0","text":"demonstrate power new workflow, included comprehensive new vignette: Integrated Pharmacovigilance tutorial, perform live analysis Leuprolide (hormone therapy) Calcitriol (Vitamin D). define individual side effect profiles using OnSIDES, use new TWOSIDES integration quantify specific risks—Anaemia—arise two drugs prescribed together.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"availability","dir":"Articles","previous_headings":"","what":"Availability","title":"Introducing dbparser 2.2.0","text":"dbparser 2.2.0 available now. can install GitHub get latest features immediately, case available CRAN yet. look forward seeing community builds new capabilities!","code":"devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"modern pharmacovigilance, analyzing drugs isolation often insufficient. Patients frequently take multiple medications, leading complex Drug-Drug Interactions (DDIs). dbparser package now provides unified framework analyze complete safety profile drug: Mechanism: Biological targets pathways DrugBank. Phenotype (Single Drug): Real-world adverse events OnSIDES. Polypharmacy (Combinations): Interaction risks TWOSIDES. vignette demonstrates complete workflow: loading three databases, merging single dvobject, performing scientific case study interaction Leuprolide Calcitriol.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"prerequisites","dir":"Articles","previous_headings":"","what":"Prerequisites","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"library(dbparser) library(dplyr) library(tidyr) library(canvasXpress) library(data.table)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"loading-and-inspecting-data","dir":"Articles","previous_headings":"","what":"1. Loading and Inspecting Data","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"use curated sample data files included dbparser package demonstrate workflow.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-drugbank-the-hub","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.1 Load DrugBank (The Hub)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"First, load mechanistic data.","code":"# Load sample DrugBank data included in the package drugbank_path <- system.file(\"two_drugs.RDS\", package = \"dbparser\") drugbank_db <- readRDS(drugbank_path) # Review the drugbank object structure show_dvobject_metadata(drugbank_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 55 3 1.5 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original DrugBank 5.1 2025-01-02 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugs$general_information 2 15 8 Kb #> drugs$drug_classification 2 9 3.8 Kb #> drugs$synonyms 15 4 3.6 Kb #> drugs$pharmacology 2 12 18.1 Kb #> drugs$international_brands 9 3 2.7 Kb #> drugs$mixtures 5 3 2 Kb #> drugs$packagers 35 3 6.2 Kb #> drugs$manufacturers 13 4 2.9 Kb #> drugs$prices 16 5 4.6 Kb #> drugs$categories 58 3 9.2 Kb #> drugs$dosages 189 4 17.4 Kb #> drugs$atc_codes 4 10 4.3 Kb #> drugs$patents 35 6 8.6 Kb #> drugs$drug_interactions 1645 4 514.7 Kb #> drugs$sequences 1 3 1.3 Kb #> drugs$calculated_properties 26 4 5.6 Kb #> drugs$experimental_properties 5 4 2.4 Kb #> drugs$external_identifiers 30 3 4.7 Kb #> drugs$pdb_entries 19 2 2.4 Kb #> drugs$affected_organisms 2 2 1.2 Kb #> drugs$groups 4 2 1.3 Kb #> drugs$external_links 5 3 2.1 Kb #> salts 2 8 2.8 Kb #> products 190 19 68.6 Kb #> references$drugs$articles 13 4 6.3 Kb #> references$drugs$links 11 4 6.1 Kb #> references$carriers$books 1 4 1.6 Kb #> references$carriers$articles 15 4 5.4 Kb #> references$enzymes$books 33 4 8.2 Kb #> references$enzymes$articles 1573 4 485.5 Kb #> references$enzymes$links 615 4 164.4 Kb #> references$enzymes$attachments 55 4 20 Kb #> references$targets$articles 101 4 27.4 Kb #> references$targets$links 14 4 7.1 Kb #> cett$carriers$general_information 1 6 1.9 Kb #> cett$carriers$actions 2 2 1.2 Kb #> cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> cett$carriers$polypeptides$synonyms 10 2 2 Kb #> cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> cett$carriers$polypeptides$go 2 3 1.5 Kb #> cett$enzymes$general_information 2 8 2.6 Kb #> cett$enzymes$actions 7 2 1.5 Kb #> cett$enzymes$polypeptides$general_information 2 20 14 Kb #> cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> cett$enzymes$polypeptides$go 21 3 3.6 Kb #> cett$targets$general_information 4 6 2.6 Kb #> cett$targets$actions 10 2 1.9 Kb #> cett$targets$polypeptides$general_information 4 20 14.2 Kb #> cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> cett$targets$polypeptides$pfams 5 3 2.1 Kb #> cett$targets$polypeptides$go 37 3 5.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-onsides-single-drug-labels","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.2 Load OnSIDES (Single-Drug Labels)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Next, load adverse event data extracted FDA labels.","code":"# Load sample OnSIDES data included in the package onsides_path <- system.file(\"onside.RDS\", package = \"dbparser\") onsides_db <- readRDS(onsides_path) # Review the onsides_db object structure show_dvobject_metadata(onsides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 8 0 2.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original OnSIDES 3.1.1 April 2025 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> product_adverse_effect 52745 7 2.2 Mb #> high_confidence 2 2 1.4 Kb #> product_label 95 5 39.7 Kb #> product_to_rxnorm 160 2 5.5 Kb #> vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> vocab_meddra_adverse_effect 347 3 31.6 Kb #> vocab_rxnorm_ingredient 3 3 2.1 Kb #> vocab_rxnorm_product 17 3 4.9 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-twosides-drug-interactions","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.3 Load TWOSIDES (Drug Interactions)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, load dataset containing adverse events reported two drugs taken simultaneously.","code":"# Load sample TWOSIDES data included in the package twosides_path <- system.file(\"twoside_raw.zip\", package = \"dbparser\") if(file.exists(twosides_path)) { twosides_db <- parseTWOSIDES(twosides_path) } else { # Fallback for demonstration if file is not yet in the build # Mocking structure similar to actual TWOSIDES output twosides_db <- list(drug_drug_interactions = data.table( drug_1_rxnorm_id = \"42375\", drug_1_concept_name = \"Leuprolide\", drug_2_rxnorm_id = \"1894\", drug_2_concept_name = \"Calcitriol\", condition_meddra_id = \"10002034\", condition_concept_name = \"Anaemia\", PRR = \"13.33\", mean_reporting_frequency = \"0.12\" )) class(twosides_db) <- c(\"TWOSIDESDb\", \"dvobject\", \"list\") attr(twosides_db, \"original_db_info\") <- list(type=\"TWOSIDES\", version=\"2.0\") } # Review structure show_dvobject_metadata(twosides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 1 0 217.6 Kb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"merging-the-databases-chaining","dir":"Articles","previous_headings":"","what":"2. Merging the Databases (Chaining)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"integrate databases chain. First, merge OnSIDES DrugBank, merge TWOSIDES result. creates single “Hub Spoke” object centered DrugBank.","code":"# Step 1: Merge DrugBank + OnSIDES db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) # Step 2: Merge Result + TWOSIDES # The function is chainable and automatically detects the existing data final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) # Review final object structure # Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' show_dvobject_metadata(final_db) #> === BASIC INFO === #> Class Total_DataFrames #> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject 68 #> Top_Level_Lists Object_Size #> 1 4 4.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> First Database DrugBank 5.1 2025-01-02 #> Second Database TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugbank$drugs$general_information 2 15 8 Kb #> drugbank$drugs$drug_classification 2 9 3.8 Kb #> drugbank$drugs$synonyms 15 4 3.6 Kb #> drugbank$drugs$pharmacology 2 12 18.1 Kb #> drugbank$drugs$international_brands 9 3 2.7 Kb #> drugbank$drugs$mixtures 5 3 2 Kb #> drugbank$drugs$packagers 35 3 6.2 Kb #> drugbank$drugs$manufacturers 13 4 2.9 Kb #> drugbank$drugs$prices 16 5 4.6 Kb #> drugbank$drugs$categories 58 3 9.2 Kb #> drugbank$drugs$dosages 189 4 17.4 Kb #> drugbank$drugs$atc_codes 4 10 4.3 Kb #> drugbank$drugs$patents 35 6 8.6 Kb #> drugbank$drugs$drug_interactions 1645 4 514.7 Kb #> drugbank$drugs$sequences 1 3 1.3 Kb #> drugbank$drugs$calculated_properties 26 4 5.6 Kb #> drugbank$drugs$experimental_properties 5 4 2.4 Kb #> drugbank$drugs$external_identifiers 30 3 4.7 Kb #> drugbank$drugs$pdb_entries 19 2 2.4 Kb #> drugbank$drugs$affected_organisms 2 2 1.2 Kb #> drugbank$drugs$groups 4 2 1.3 Kb #> drugbank$drugs$external_links 5 3 2.1 Kb #> drugbank$salts 2 8 2.8 Kb #> drugbank$products 190 19 68.6 Kb #> drugbank$references$drugs$articles 13 4 6.3 Kb #> drugbank$references$drugs$links 11 4 6.1 Kb #> drugbank$references$carriers$books 1 4 1.6 Kb #> drugbank$references$carriers$articles 15 4 5.4 Kb #> drugbank$references$enzymes$books 33 4 8.2 Kb #> drugbank$references$enzymes$articles 1573 4 485.5 Kb #> drugbank$references$enzymes$links 615 4 164.4 Kb #> drugbank$references$enzymes$attachments 55 4 20 Kb #> drugbank$references$targets$articles 101 4 27.4 Kb #> drugbank$references$targets$links 14 4 7.1 Kb #> drugbank$cett$carriers$general_information 1 6 1.9 Kb #> drugbank$cett$carriers$actions 2 2 1.2 Kb #> drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb #> drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb #> drugbank$cett$enzymes$general_information 2 8 2.6 Kb #> drugbank$cett$enzymes$actions 7 2 1.5 Kb #> drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb #> drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb #> drugbank$cett$targets$general_information 4 6 2.6 Kb #> drugbank$cett$targets$actions 10 2 1.9 Kb #> drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb #> drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb #> drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb #> onsides$product_adverse_effect 52745 7 2.2 Mb #> onsides$high_confidence 2 2 1.4 Kb #> onsides$product_label 95 5 39.7 Kb #> onsides$product_to_rxnorm 160 2 5.5 Kb #> onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb #> onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb #> onsides$vocab_rxnorm_product 17 3 4.9 Kb #> integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb #> integrated_data$high_confidence_enriched 2 3 1.6 Kb #> integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb #> integrated_data$drug_drug_interactions 1706 17 300.9 Kb #> twosides$drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-leuprolide-db00007","dir":"Articles","previous_headings":"","what":"3. Single Drug Analysis: Leuprolide (DB00007)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Scientific Context: Leuprolide GnRH analog. first establish baseline side effect profile OnSIDES.","code":"target_drug_id <- \"DB00007\" # Leuprolide # 1. Get the RxNorm ID from the bridge table mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id) target_rxcui <- mapping_df$rxcui[1] print(paste0(\"DrugBank ID: \", target_drug_id, \" maps to RxNorm CUI: \", target_rxcui)) #> [1] \"DrugBank ID: DB00007 maps to RxNorm CUI: 42375\""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"extract-baseline-adverse-events-onsides","dir":"Articles","previous_headings":"3. Single Drug Analysis: Leuprolide (DB00007)","what":"3.1 Extract Baseline Adverse Events (OnSIDES)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"# 1. Find product labels linked to this ingredient product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui) %>% pull(product_id) target_label_ids <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis) %>% pull(label_id) # 2. Extract and summarize events ae_summary <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) # Fill NAs for demo purposes (if vocab is incomplete in sample) ae_summary <- ae_summary %>% mutate(meddra_name = case_when( effect_meddra_id == 10033336 ~ \"Pain\", effect_meddra_id == 10039769 ~ \"Rash\", effect_meddra_id == 10052995 ~ \"Hot flush\", effect_meddra_id == 10009226 ~ \"Constipation\", effect_meddra_id == 10006068 ~ \"Bone pain\", TRUE ~ meddra_name )) %>% rename(Adverse_Event = meddra_name) print(ae_summary) #> # A tibble: 10 × 3 #> effect_meddra_id Adverse_Event Count #> #> 1 10033336 Pain 10659 #> 2 10029197 Nervous 711 #> 3 10039769 Rash 526 #> 4 10017735 Gas 504 #> 5 10010904 Convulsion 424 #> 6 10019211 Headache 351 #> 7 10052995 Hot flush 350 #> 8 10010914 Convulsions 349 #> 9 10009226 Constipation 262 #> 10 10006068 Bone pain 247"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-calcitriol-db00136","dir":"Articles","previous_headings":"","what":"4. Single Drug Analysis: Calcitriol (DB00136)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"repeat process Calcitriol establish baseline.","code":"target_drug_id_2 <- \"DB00136\" # Get RxCUI mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id_2) target_rxcui_2 <- mapping_df_2$rxcui[1] # Get Products & Labels product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui_2) %>% pull(product_id) target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis_2) %>% pull(label_id) # Summarize Events ae_summary_2 <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids_2) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) %>% mutate(meddra_name = ifelse(is.na(meddra_name), paste0(\"MedDRA_\", effect_meddra_id), meddra_name)) %>% rename(Adverse_Event = meddra_name)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"polypharmacy-analysis-drug-drug-interactions","dir":"Articles","previous_headings":"","what":"5. Polypharmacy Analysis: Drug-Drug Interactions","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"New Insight: happens Leuprolide Calcitriol taken together? query integrated_data$drug_drug_interactions table, populated merge_drugbank_twosides. table allows us look interactions DrugBank ID, using enriched columns provided merge.","code":"# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) interaction_data <- final_db$integrated_data$drug_drug_interactions %>% filter( (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) ) %>% arrange(desc(as.numeric(PRR))) %>% select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) print(interaction_data) #> drug_name_1 drug_name_2 condition_concept_name PRR #> #> 1: Leuprolide Calcitriol Platelet count decreased 15 #> 2: Leuprolide Calcitriol Disturbance in attention 5 #> 3: Leuprolide Calcitriol Haemorrhage 5 #> mean_reporting_frequency #> #> 1: 0.0909091 #> 2: 0.0303030 #> 3: 0.0303030"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"visualization-of-interaction-risks","dir":"Articles","previous_headings":"5. Polypharmacy Analysis: Drug-Drug Interactions","what":"5.1 Visualization of Interaction Risks","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"can visualize specific adverse events associated combination, ranked Proportional Reporting Ratio (PRR) (measure signal strength).","code":"if(nrow(interaction_data) > 0) { # Prepare data for canvasXpress cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) rownames(cx_int_data) <- interaction_data$condition_concept_name canvasXpress( data = t(cx_int_data), graphType = \"Bar\", title = \"Polypharmacy Risks: Leuprolide + Calcitriol\", subtitle = \"Data from TWOSIDES\", xAxisTitle = \"Signal Strength (PRR)\", yAxisTitle = \"Adverse Event\", showLegend = FALSE ) } else { print(\"No interaction data found for this specific pair in the sample dataset.\") }"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"comparative-overview","dir":"Articles","previous_headings":"","what":"6. Comparative Overview","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, can view single-drug profiles alongside interaction profile see new risks emerge.","code":"# 1. Prepare Single Drug Data s1 <- ae_summary %>% mutate(Type = \"Leuprolide (Alone)\") %>% select(Adverse_Event, Value=Count, Type) s2 <- ae_summary_2 %>% mutate(Type = \"Calcitriol (Alone)\") %>% select(Adverse_Event, Value=Count, Type) # 2. Prepare Interaction Data (Show Top 5) # Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, # so we visualize them to show relative importance within their own context. s3 <- interaction_data %>% head(5) %>% mutate(Type = \"Interaction (PRR)\", Value = as.numeric(PRR)) %>% select(Adverse_Event = condition_concept_name, Value, Type) # 3. Combine combined_data <- bind_rows(s1, s2, s3) %>% group_by(Type) %>% slice_max(Value, n = 5) %>% ungroup() # 4. Reshape for Matrix comparison_matrix <- combined_data %>% pivot_wider(names_from = Type, values_from = Value, values_fill = 0) cx_compare <- as.data.frame(comparison_matrix[, -1]) rownames(cx_compare) <- comparison_matrix$Adverse_Event # 5. Plot canvasXpress( data = cx_compare, graphType = \"Bar\", title = \"Safety Profile Comparison\", subtitle = \"Single Drug Frequencies vs. Interaction PRR\", xAxisTitle = \"Value\", yAxisTitle = \"Adverse Event\", legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"conclusion","dir":"Articles","previous_headings":"","what":"7. Conclusion","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"analysis highlights power dbparser integration ecosystem: DrugBank provided identity mechanism Leuprolide Calcitriol. OnSIDES quantified individual side effects (e.g., Pain, Hot Flushes). TWOSIDES revealed specific risks drugs combined (e.g., Anaemia). chaining merge_drugbank_onsides merge_drugbank_twosides, researchers can perform comprehensive safety assessments across mechanistic, real-world, polypharmacy domains just lines R code.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Mohammed Ali. Author, maintainer. Ali Ezzat. Author. Hao Zhu. Reviewer. Emma Mendelsohn. Reviewer.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. R package version 2.2.0.","code":"@Manual{, title = {DrugBank Database XML Parser}, author = {Mohammed Ali and Ali Ezzat}, organization = {Interstellar for Consultinc inc.}, note = {R package version 2.2.0}, url = {https://CRAN.R-project.org/package=dbparser}, }"},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"interest fostering open welcoming environment, contributors maintainers pledge making participation project community harassment-free experience everyone, regardless age, body size, disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, religion, sexual identity orientation.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes creating positive environment include: Using welcoming inclusive language respectful differing viewpoints experiences Gracefully accepting constructive criticism Focusing best community Showing empathy towards community members Examples unacceptable behavior participants include: use sexualized language imagery unwelcome sexual attention advances Trolling, insulting/derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical electronic address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-responsibilities","dir":"","previous_headings":"","what":"Our Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Project maintainers responsible clarifying standards acceptable behavior expected take appropriate fair corrective action response instances unacceptable behavior. Project maintainers right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, ban temporarily permanently contributor behaviors deem inappropriate, threatening, offensive, harmful.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within project spaces public spaces individual representing project community. Examples representing project community include using official project e-mail address, posting via official social media account, acting appointed representative online offline event. Representation project may defined clarified project maintainers.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported contacting project team mohammed.ali@edu.dsti.institute. complaints reviewed investigated result response deemed necessary appropriate circumstances. project team obligated maintain confidentiality regard reporter incident. details specific enforcement policies may posted separately. Project maintainers follow enforce Code Conduct good faith may face temporary permanent repercussions determined members project’s leadership.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 1.4, available https://www.contributor-covenant.org/version/1/4/code--conduct.html answers common questions code conduct, see https://www.contributor-covenant.org/faq","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contributing to dbparser","title":"Contributing to dbparser","text":"First , thanks considering contributing dbparser! 👍 ’s people like make rewarding us - project maintainers - work dbparser. 😊 dbparser open source project, maintained people care. directly funded .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of conduct","title":"Contributing to dbparser","text":"Please note project released Contributor Code Conduct. participating project agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"how-you-can-contribute","dir":"","previous_headings":"","what":"How you can contribute","title":"Contributing to dbparser","text":"several ways can contribute project. want know contribute open source projects like one, see Open Source Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"share-the-love-heart","dir":"","previous_headings":"How you can contribute","what":"Share the love ❤️","title":"Contributing to dbparser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"ask-a-question-interrobang","dir":"","previous_headings":"How you can contribute","what":"Ask a question ⁉️","title":"Contributing to dbparser","text":"Using our_package got stuck? Browse documentation see can find solution. Still stuck? Post question issue GitHub. offer user support, ’ll try best address , questions often lead better documentation discovery bugs. Want ask question private? Contact package maintainer email.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"propose-an-idea-bulb","dir":"","previous_headings":"How you can contribute","what":"Propose an idea 💡","title":"Contributing to dbparser","text":"idea new our_package feature? Take look documentation issue list see isn’t included suggested yet. , suggest idea issue GitHub. can’t promise implement idea, helps : Explain detail work. Keep scope narrow possible. See want contribute code idea well.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"report-a-bug-bug","dir":"","previous_headings":"How you can contribute","what":"Report a bug 🐛","title":"Contributing to dbparser","text":"Using our_package discovered bug? ’s annoying! Don’t let others experience report issue GitHub can fix . good bug report makes easier us , please include: operating system name version (e.g. Mac OS 10.13.6). details local setup might helpful troubleshooting. Detailed steps reproduce bug.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"improve-the-documentation-open_book","dir":"","previous_headings":"How you can contribute","what":"Improve the documentation 📖","title":"Contributing to dbparser","text":"Noticed typo website? Think function use better example? Good documentation makes difference, help improve welcome!","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"the-website","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"The website","title":"Contributing to dbparser","text":"website generated pkgdown. means don’t write html: content pulled together documentation code, vignettes, Markdown files, package DESCRIPTION _pkgdown.yml settings. know way around pkgdown, can propose file change improve documentation. , report issue can point right direction.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"function-documentation","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"Function documentation","title":"Contributing to dbparser","text":"Functions described comments near code translated documentation using roxygen2. want improve function description: Go R/ directory code repository. Look file name function. Propose file change update function documentation roxygen comments (starting #').","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"contribute-code-pencil","dir":"","previous_headings":"How you can contribute","what":"Contribute code 📝","title":"Contributing to dbparser","text":"Care fix bugs implement new functionality our_package? Awesome! 👏 look issue list leave comment things want work . See also development guidelines .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"development-guidelines","dir":"","previous_headings":"","what":"Development guidelines","title":"Contributing to dbparser","text":"try follow GitHub flow development. Fork repo clone computer. learn process, see guide. forked cloned project since worked , pull changes original repo clone using git pull upstream master. Open RStudio project file (.Rproj). Write code. Test code (bonus points adding unit tests). Document code (see function documentation ). Check code devtools::check() aim 0 errors warnings. Commit push changes. Submit pull request.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Drugs Databases Parser","text":"Drugs databases vary much formats structures making related data analysis easy job requires lot efforts work two databases together DrugBank, OnSIDES, TWOSIDES. Hence, dbparser package aims parse different public drugs databases single unified format R object called dvobject (stands drugverse object). recent updates, dbparser evolved integration engine, allowing merge mechanistic data (DrugBank) real-world phenotypic data (OnSIDES) drug-drug interaction risks (TWOSIDES). help : working single data object multiple databases different formats, using R analysis capabilities easily drugs data, ease transferring data researchers performing required data analysis dvobject storing results object easy manner.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"dvobject-structure","dir":"","previous_headings":"Overview","what":"dvobject Structure","title":"Drugs Databases Parser","text":"dvobject introduces unified compressed format drugs data. R list object. single database (e.g., DrugBank): contains one following sub-lists: drugs: list data.frames contain drugs information (.e. synonyms, classifications, …) mandatory list salts: data.frame contains drugs salts information products: data.frame commercially available drugs products world references: data.frame articles, links textbooks drugs CETT data cett: list data.frames contain targets, enzymes, carriers transporters information merged database (Integrated Pharmacovigilance): databases merged using merge_drugbank_onsides merge_drugbank_twosides, dvobject becomes nested structure containing: drugbank: mechanistic hub. onsides: side-effect data (FDA labels). twosides: drug-drug interaction data. integrated_data: Enriched tables bridge databases (e.g., linking DrugBank IDs OnSIDES adverse events). metadata: Detailed provenance contained datasets.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"drug-databases","dir":"","previous_headings":"","what":"Drug Databases","title":"Drugs Databases Parser","text":"Parsers available following databases (progress list)","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_1-drugbank","dir":"","previous_headings":"Drug Databases","what":"1. DrugBank","title":"Drugs Databases Parser","text":"DrugBank database comprehensive, freely accessible, online database containing information drugs drug targets. bioinformatics cheminformatics resource, DrugBank combines detailed drug (.e. chemical, pharmacological pharmaceutical) data comprehensive drug target (.e. sequence, structure, pathway) information. information DrugBank can found . raw form, DrugBank database single XML file. Users must create account DrugBank request permission download database. Note may take couple days. dbparser package parses DrugBank XML database R tibbles can explored analyzed user, check tutorial details. waiting access DrugBank database, intend deep dive data, may wish use dbdataset package, contains DrugBank database already parsed dvobject. Note large package exceeds limit set CRAN. available GitHub. dbparser tested DrugBank versions 5.1.0 5.1.12 successfully. find errors versions version please submit issue .","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_2-onsides-the-phenotype","dir":"","previous_headings":"Drug Databases","what":"2. OnSIDES (The Phenotype)","title":"Drugs Databases Parser","text":"OnSIDES provides adverse drug events extracted thousands FDA drug labels using machine learning. * Parser: parseOnSIDES() * Input: Directory containing OnSIDES CSV files.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_3-twosides-polypharmacy","dir":"","previous_headings":"Drug Databases","what":"3. TWOSIDES (Polypharmacy)","title":"Drugs Databases Parser","text":"TWOSIDES provides data drug-drug interactions adverse events arise two drugs taken together. * Parser: parseTWOSIDES() * Input: TWOSIDES.csv.gz file.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"quick-start-integration-pipeline","dir":"","previous_headings":"","what":"Quick Start: Integration Pipeline","title":"Drugs Databases Parser","text":"power dbparser lies ability chain parsers mergers together. can build complete pharmacovigilance dataset: detailed case study, please refer Integrated Pharmacovigilance Vignette.","code":"library(dbparser) library(dplyr) # 1. Parse the raw databases drugbank_db <- parseDrugBank(\"data/drugbank.xml\") onsides_db <- parseOnSIDES(\"data/onsides/\") twosides_db <- parseTWOSIDES(\"data/TWOSIDES.csv.gz\") # 2. Build the Integrated Knowledge Graph # DrugBank serves as the hub. We chain the merges. final_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db) # 3. Analyze Results # Example: Accessing the enriched drug-drug interaction table head(final_db$integrated_data$drug_drug_interactions)"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Drugs Databases Parser","text":"can install released version dbparser CRAN : can install latest updates directly repo","code":"install.packages(\"dbparser\") library(devtools) devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Drugs Databases Parser","text":"Please note ‘dbparser’ project released Contributor Code Conduct. contributing project, agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"contributing-guide","dir":"","previous_headings":"","what":"Contributing Guide","title":"Drugs Databases Parser","text":"👍🎉 First , thanks taking time contribute! 🎉👍 Please review Contributing Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"share-the-love-heart","dir":"","previous_headings":"","what":"Share the love ❤️","title":"Drugs Databases Parser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing ","code":"citation(\"dbparser\") #> To cite dbparser in publications use: #> #> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. #> R package version 2.2.0. #> #> A BibTeX entry for LaTeX users is #> #> @Manual{, #> title = {DrugBank Database XML Parser}, #> author = {Mohammed Ali and Ali Ezzat}, #> organization = {Interstellar for Consultinc inc.}, #> note = {R package version 2.2.0}, #> url = {https://CRAN.R-project.org/package=dbparser}, #> }"},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":null,"dir":"Reference","previous_headings":"","what":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"add_database_info Assign passed databases db metadata passed dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"","code":"add_database_info( dvobject, db_type = \"DrugBank\", db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject dvobject assign metadata db_type database type (defualt=\"DrugBank\") db_version database version string db_exported_date database official export date","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"Return list articles used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"","code":"drugs_articles() carriers_articles() enzymes_articles() targets_articles() transporters_articles()"},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). pubmed-id PubMed identifier article. citation Article citation standard format. parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"Return list attachment used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"","code":"drugs_attachments() carriers_attachments() enzymes_attachments() targets_attachments() transporters_attachments()"},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). title title attachment. url url download attachment . parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"Return list text books used references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"","code":"drugs_textbooks() carriers_textbooks() enzymes_textbooks() targets_textbooks() transporters_textbooks()"},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). isbn ISBN identifying textbook. citation Textbook citation standard format. parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Build Metadata Data Frame — build_metadata","title":"Build Metadata Data Frame — build_metadata","text":"Build Metadata Data Frame","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Build Metadata Data Frame — build_metadata","text":"","code":"build_metadata(attrs, has_second_db, second_db_name)"},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Build Metadata Data Frame — build_metadata","text":"attrs Attributes list has_second_db Logical indicating second database exists second_db_name Name second database attribute","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Build Metadata Data Frame — build_metadata","text":"Data.frame database metadata","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"Collection related actions","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"","code":"carriers_actions() enzymes_actions() targets_actions() transporters_actions()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"tibble 2 variables: action describe related action parent_id carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"Protein targets drug action, enzymes inhibited/induced involved metabolism, carrier transporter proteins involved movement drug across biological membranes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"","code":"carriers() enzymes() targets() transporters()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"tibble 6 variables (8 enzymes): id Universal Protein Resource (UniProt) Identifier record name related name organism Organism protein comes . known_action Whether pharmacological action drug due target interaction. inhibition-strength Whether strength enzyme inhibition strong, moderate, unknown. applies enzymes induction-strength Whether strength enzyme induction strong unknown. applies enzymes position related position parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"Extract descriptions identified polypeptide external identifiers targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"","code":"carriers_polypep_ex_ident() enzymes_polypep_ex_ident() targets_polypep_ex_ident() transporters_polypep_ex_ident()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"tibble 3 variables: resource Name source database. identifier Identifier drug given resource. parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"Extract descriptions identified polypeptide go classifier targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"","code":"carriers_polypeptides_go() enzymes_polypeptides_go() targets_polypeptides_go() transporters_polypeptides_go()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"tibble 3 variables: category description parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"returns carriers, enzymes,targets transporters node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"","code":"cett_nodes_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"list CETT valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"Extract descriptions identified polypeptide targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"","code":"carriers_polypeptides() enzymes_polypeptides() targets_polypeptides() transporters_polypeptides()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"tibble 20 variables: id Universal Protein Resource (UniProt) identifier source Specifies whether identified polypeptide ID associated following UniProt knowledge bases: Swiss-Prot, manually annotated reviewed, TrEMBL, automatically annotated reviewed. name general_function General summary physiological function polypeptide specific_function specific description polypeptide’s physiological function within cell. gene_name short name commonly associated associated gene. Eg. PTGS1. locus specific chromosomal location position gene’s sequence chromosome. cellular_location cellular location polypeptide. transmembrane_regions Areas polypeptide sequence span biological membrane. signal_regions Location signal peptides within polypeptide sequence. theoretical_pi Theoretical isoelectric point. molecular_weight molecular weight polypeptide. chromosome_location chromosomal location polypeptide gene organism organism polypeptide functions. organism_ncbi_taxonomy_id amino_acid_sequence amino acid sequence polypeptide amino_acid_format gene_sequence sequence associated gene. gene_format parent_key carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"Extract descriptions identified polypeptide PFAMS targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"","code":"carriers_polypeptides_pfams() enzymes_polypeptides_pfams() targets_polypeptides_pfams() transporters_polypeptides_pfams()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"tibble 3 variables: name sequence associated gene. identifier parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"Extract descriptions identified polypeptide synonyms targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"","code":"carriers_polypeptides_syn() enzymes_polypeptides_syn() targets_polypeptides_syn() transporters_polypeptides_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"tibble 2 variables: synonym parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":null,"dir":"Reference","previous_headings":"","what":"Count Top Level Lists — count_top_level_lists","title":"Count Top Level Lists — count_top_level_lists","text":"Count Top Level Lists","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Count Top Level Lists — count_top_level_lists","text":"","code":"count_top_level_lists(obj)"},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Count Top Level Lists — count_top_level_lists","text":"obj Object analyze","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Count Top Level Lists — count_top_level_lists","text":"Integer count top-level lists (excluding data.frames)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":null,"dir":"Reference","previous_headings":"","what":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"main purpose `dbparser` package parse [DrugBank](https://go.drugbank.com/) database downloadable XML format [link](https://go.drugbank.com/releases/latest).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parsed data can explored analyzed. achieve purpose, `dbparser“ package provides three main categories functions: - xml db reader, - DrugBank elements parsers, information kindly check reference/index (https://docs.ropensci.org/dbparser/reference/index.html)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"xml-db-reader-functions","dir":"Reference","previous_headings":"","what":"xml db reader functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Reads DrugBank xml database build drug elements full tree memory","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"parsers-functions","dir":"Reference","previous_headings":"","what":"parsers functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parser function responsible parsing certain drug element returning tibble. Check tutorial (https://docs.ropensci.org/dbparser/articles/dbparser.html)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Maintainer: Mohammed Ali moh_fcis@yahoo.com Authors: Ali Ezzat ali_ezzat85@yahoo.com contributors: Hao Zhu haozhu233@gmail.com [reviewer] Emma Mendelsohn [reviewer]","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Affected Organism parser — drug_affected_organisms","title":"Drug Affected Organism parser — drug_affected_organisms","text":"Organisms drug may display activity; activity may depend local susceptibility patterns resistance.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Affected Organism parser — drug_affected_organisms","text":"","code":"drug_affected_organisms()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Affected Organism parser — drug_affected_organisms","text":"tibble 2 variables: affected-organism affected-organism name drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ahfs-codes parser — drug_ahfs_codes","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"American Hospital Formulary Service (AHFS) identifier drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"","code":"drug_ahfs_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"tibble following variables: ahfs-code drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ATC Codes element parser — drug_atc_codes","title":"Drug ATC Codes element parser — drug_atc_codes","text":"Anatomical Therapeutic Classification (ATC) code drug assigned World Health Organization Anatomical Chemical Classification System.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ATC Codes element parser — drug_atc_codes","text":"","code":"drug_atc_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ATC Codes element parser — drug_atc_codes","text":"tibble 10 variables","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug ATC Codes element parser — drug_atc_codes","text":"`atc-code“ row one level. atc-code level> code code assigned World Health Organization Anatomical Therapeutic Chemical Classification system.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Calculated Properties parser — drug_calc_prop","title":"Drug Calculated Properties parser — drug_calc_prop","text":"Drug properties predicted ChemAxon ALOGPS based imputed chemical structure. Associated links redirect descriptions specific term.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Calculated Properties parser — drug_calc_prop","text":"","code":"drug_calc_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Calculated Properties parser — drug_calc_prop","text":"tibble 4 variables: kind Name property. value Predicted physicochemical properties; obtained use prediction software ALGOPS ChemAxon. source Name software used calculate property, either ChemAxon ALOGPS. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Categories parser — drug_categories","title":"Drug Categories parser — drug_categories","text":"General categorizations drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Categories parser — drug_categories","text":"","code":"drug_categories()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Categories parser — drug_categories","text":"tibble 2 variables: category category name mesh-id Medical Subjects Headings (MeSH) identifier category. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Classification parser — drug_classification","title":"Drug Classification parser — drug_classification","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Classification parser — drug_classification","text":"","code":"drug_classification()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Classification parser — drug_classification","text":"tibble 9 variables: description direct-parent kingdom superclass class subclass alternative-parent One alternative parents substituent One substituents drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Dosages parser — drug_dosages","title":"Drug Dosages parser — drug_dosages","text":"list commercially available dosages drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Dosages parser — drug_dosages","text":"","code":"drug_dosages()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Dosages parser — drug_dosages","text":"tibble following variables: form pharmaceutical formulation drug introduced body route path drug product taken body. strength amount active drug ingredient provided dosage drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Experimental Properties parser — drug_exp_prop","title":"Drug Experimental Properties parser — drug_exp_prop","text":"Drug properties experimentally proven","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Experimental Properties parser — drug_exp_prop","text":"","code":"drug_exp_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Experimental Properties parser — drug_exp_prop","text":"tibble following variables: kind Name property. value Drug properties experimentally proven. source Reference source experimental data. drugbank_id drugbank id following experimental properties provided: Water Solubility experimentally determined aqueous solubility molecule. Molecular Formula Protein formula Biotech drugs Molecular Weight Protein weight Biotech drugs. Melting Point experimentally determined temperature drug molecule changes solid liquid atmospheric temperature. Boiling Point experimentally determined temperature drug molecule changes liquid gas atmospheric temperature. Hydrophobicity ability molecule repel water rather absorb dissolve water. Isoelectric Point pH value net electric charge molecule zero. caco2 Permeability continuous line heterogenous human epithelial colorectal adenocarcinoma cells, CAC02 cells employed model human intestinal absorption various drugs compounds. CAC02 cell permeability ultimately assay measure drug absorption. pKa experimentally determined pka value molecule logP experimentally determined partition coefficient (LogP) based ratio solubility molecule 1-octanol compared water. logS intrinsic solubility given compound concentration equilibrium solid phase dissolves solution, given natural logarithm (LogS) concentration. Radioactivity property spontaneously emit particles (alpha, beta, neutron) radiation (gamma, K capture), time, decay certain nuclides.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Links parser — drug_external_links","title":"Drug External Links parser — drug_external_links","text":"Links websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Links parser — drug_external_links","text":"","code":"drug_external_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Links parser — drug_external_links","text":"tibble following variables: resource Name source website. identifier Identifier drug given resource drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Identifiers parser — drug_ex_identity","title":"Drug External Identifiers parser — drug_ex_identity","text":"Identifiers used websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Identifiers parser — drug_ex_identity","text":"","code":"drug_ex_identity()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Identifiers parser — drug_ex_identity","text":"tibble following variables: resource Name source database. identifier Identifier drug given resource. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_food_interactions","title":"Drug Groups parser — drug_food_interactions","text":"Food may interact drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_food_interactions","text":"","code":"drug_food_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_food_interactions","text":"tibble following variables: food-interaction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs General Information parser — drug_general_information","title":"Drugs General Information parser — drug_general_information","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs General Information parser — drug_general_information","text":"","code":"drug_general_information()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs General Information parser — drug_general_information","text":"tibble 15 variables: primary_key DrugBank id other_keys identifiers may associated drug type Either small molecule, biotech. Biotech used drug derived living systems organisms, usually composed high molecular weight mixtures protein, small molecule describes low molecular weight organic compound. name created Date drug first added DrugBank. updated Denotes drug last updated DrugBank. description Descriptions drug chemical properties, history regulatory status. cas_number Chemical Abstracts Service (CAS) registry number assigned drug. unii Unique Ingredient Identifier (UNII) drug. average_mass weighted average isotopic masses drug state One solid, liquid, gas monoisotopic_mass mass abundant isotope drug synthesis_reference Citation synthesis drug molecule. fda_label Contains URL accessing uploaded United States Food Drug Administration (FDA) Monograph drug. msds Contains URL accessing Material Safety Data Sheet (MSDS) drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_groups","title":"Drug Groups parser — drug_groups","text":"Groups drug belongs . May include : approved, vet_approved, nutraceutical, illicit, withdrawn, investigational, experimental.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_groups","text":"","code":"drug_groups()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_groups","text":"tibble 2 variables: group drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Interactions parser — drug_interactions","title":"Drug Interactions parser — drug_interactions","text":"Drug-drug interactions detailing drugs , administered concomitantly drug interest, affect activity result adverse effects. interactions may synergistic antagonistic depending physiological effects mechanism action drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Interactions parser — drug_interactions","text":"","code":"drug_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Interactions parser — drug_interactions","text":"tibble following variables: drugbank-id DrugBank ID interacting drug. name Name interacting drug. description Textual description physiological consequences drug interaction drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug International Brands parser — drug_intern_brand","title":"Drug International Brands parser — drug_intern_brand","text":"proprietary names used manufacturers commercially available forms drug, focusing brand names products available countries Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug International Brands parser — drug_intern_brand","text":"","code":"drug_intern_brand()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug International Brands parser — drug_intern_brand","text":"tibble 4 variables: brand proprietary, well-known name given drug manufacturer. company company manufacturer uses name. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Manufacturers parser — drug_manufacturers","title":"Drug Manufacturers parser — drug_manufacturers","text":"list companies manufacturing commercially available forms drug available Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Manufacturers parser — drug_manufacturers","text":"","code":"drug_manufacturers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Manufacturers parser — drug_manufacturers","text":"tibble following variables: generic list companies manufacturing generic form drug. url link companies manufacturing drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Mixtures parser — drug_mixtures","title":"Drug Mixtures parser — drug_mixtures","text":"commercially available products drug available combination drug molecules","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Mixtures parser — drug_mixtures","text":"","code":"drug_mixtures()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Mixtures parser — drug_mixtures","text":"tibble 4 variables: name proprietary name provided manufacturer combination product. ingredients list ingredients, separated addition symbols supplemental-ingredients List additional active ingredients clinically relevant main indication product, separated addition symbols. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns drug node valid options. — drug_node_options","title":"returns drug node valid options. — drug_node_options","text":"returns drug node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns drug node valid options. — drug_node_options","text":"","code":"drug_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns drug node valid options. — drug_node_options","text":"list drug valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Packagers parser — drug_packagers","title":"Drug Packagers parser — drug_packagers","text":"list companies packaging drug re-distribution.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Packagers parser — drug_packagers","text":"","code":"drug_packagers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Packagers parser — drug_packagers","text":"tibble 2 variables: name url link companies packaging drug re-distribution. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"Drug Patents parser property right issued United States Patent Trademark Office (USPTO) inventor limited time, exchange public disclosure invention patent granted. Drugs may issued multiple patents.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"","code":"drug_patents()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"tibble following variables: number patent number(s) associated drug. country country issued patent rights. approved date patent request filed. expires date patent rights expire. pediatric-extension Indicates whether pediatric extension approved patent. Granted pediatric extensions provide additional 6 months market protection. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway parser — drug_pathway","title":"Drug Pathway parser — drug_pathway","text":"Metabolic, disease, biological pathways drug involved , identified Small Molecule Protein Database (SMPDB).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway parser — drug_pathway","text":"","code":"drug_pathway()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway parser — drug_pathway","text":"tibble following variables: smpdb-id Small Molecule Pathway Database identifier pathway. name Pathway name category Pathway category drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Drugs parser — drug_pathway_drugs","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"Drugs involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"","code":"drug_pathway_drugs()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"tibble pathway drugs properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Enzymes parser — drug_pathway_enzyme","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"Enzymes involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"","code":"drug_pathway_enzyme()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"tibble pathway properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug pdb-entries parser — drug_pdb_entries","title":"Drug pdb-entries parser — drug_pdb_entries","text":"Protein Data Bank (PDB) identifiers drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug pdb-entries parser — drug_pdb_entries","text":"","code":"drug_pdb_entries()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug pdb-entries parser — drug_pdb_entries","text":"tibble following variables: pdb-entry drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pharmacology parser — drug_pharmacology","title":"Drug Pharmacology parser — drug_pharmacology","text":"Describes use, mechanism action, pharmacokinetics, pharmacodynamics, physiological biochemical effects body.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pharmacology parser — drug_pharmacology","text":"","code":"drug_pharmacology()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pharmacology parser — drug_pharmacology","text":"tibble following variables: indication approved conditions, diseases, states drug can safely effectively used. indication considered FDA-approved following designations: NDA, ANDA, BLA, OTC. May also include indications countries, Canada (Health Canada) Europe (European Medicines Agency). pharmacodynamics description drug modifies affects organism used . May include effects body desired (enzyme protein targets example) undesired (also known “side effects”). contrast pharmacokinetics, describes body modifies drug used. mechanism_of_action component pharmacodynamics describes biochemical interaction drug produces intended effect. May include exact molecular protein enzyme targets / description physiological effects produced. toxicity adverse reaction, side effect, may may occur use drug. May attributed number effects including: enhanced therapeutic effect, rare anaphylactic reactions, interactions medications, unanticipated binding molecule different sites within body. metabolism description chemical degradation drug molecule within body; commonly enzymes Cytochrome P450 (CYP) system liver. absorption description movement drug site administration bloodstream target tissue. Common pharmacokinetic metrics used evaluate absorption include Area Curve (AUC), bioavailability (F), maximum concentration (Cmax), time maximum concentration (Tmax). half-life period time takes amount drug body reduced one half. Provides description quickly drug eliminated much available bloodstream. protein-binding description drug’s affinity plama proteins proportion drug bound circulation within body. route_of_elimination description pathway used excrete drug body. Common pharmacokinetic parameters used evaluate excretion include elimination half life, renal clearance, tracking radiolabelled compounds renal GI system. volume_of_distribution Vd drug represents degree distributed body tissue compared plasma. clearance pharmacokinetic measurement rate removal drug plasma, expressed mL/min; reflects rate elimination drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Prices Parsers — drug_prices","title":"Drug Prices Parsers — drug_prices","text":"Unit drug prices","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Prices Parsers — drug_prices","text":"","code":"drug_prices()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Prices Parsers — drug_prices","text":"tibble 5 variables: description cost Drug price per unit currency Currency price, example: US. unit parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Products parser — drug_products","title":"Drug Products parser — drug_products","text":"list commercially available products Canada United States contain drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Products parser — drug_products","text":"","code":"drug_products()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Products parser — drug_products","text":"tibble 32 variables: name proprietary name(s) provided manufacturer commercially available products containing drug. labeller corporation responsible labelling product. ndc-id National Drug Code (NDC) identifier drug ndc-product-code National Drug Code (NDC) product code FDA National Drug Code directory. dpd-id Drug Product Database (DPD) identification number (.k.. DIN) Canadian Drug Product Database. present drugs marketed Canada ema-product-code EMA product code European Medicines Agency Database. present products authorized central procedure marketing European Union. ema-ma-number EMA marketing authorization number European Medicines Agency Database. present products authorized central procedure marketing European Union. started-marketing-starting date market approval. ended-marketing-ending date market approval. dosage-form pharmaceutical formulation drug introduced body. strength amount active drug ingredient provided dosage route path drug product taken body fda-application-number New Drug Application [NDA] number assigned drug FDA. --counter list Counter (OTC) forms drug. generic Whether product generic drug. approved Indicates whether drug approved regulating government. country country commercially available drug approved. source Source product information. example, value DPD indicates information retrieved Canadian Drug Product Database. standing One good, discordant, deprecated. Distinguishes products date ingredient information (good) products conflicting information (discordant) products removed active label (deprecated). standing-updated-date standing last updated standing-reason Explains non-good standing product. One : ingredient_change, code_duplication, invalid, removed. jurisdiction-marketing-category marketing category product jurisdiction branded Whether product named brand prescription Whether product available prescription unapproved Whether product approved jurisdiction vaccine Whether product vaccine allergenic Whether product used allergenic testing cosmetic Whether product cosmetic, sunscreen kit Whether product kit composed multiple distinct parts solo Whether product single active ingredient available Whether product can sold jurisdiction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Parsers — drug_reactions","title":"Drug Reactions Parsers — drug_reactions","text":"Extract sequential representation metabolic reactions drug molecule involved . Depending available information, may include metabolizing enzymes, reaction type, substrates, products, pharmacological activity metabolites, structural representation biochemical reactions.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Parsers — drug_reactions","text":"","code":"drug_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Parsers — drug_reactions","text":"tibble 5 variables: sequence Reactions displayed within numerical sequence left_drugbank_name substrate reaction. Maybe drug metabolite. rightt_drugbank_name product reaction. Maybe drug metabolite. left_drugbank_id right_drugbank_id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"Enzymes involved metabolizing drug","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"","code":"drug_reactions_enzymes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"tibble 3 variables: name uniprot-id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Salts parser — drug_salts","title":"Drug Salts parser — drug_salts","text":"Available salt forms drug. Ions hydrochloride, sodium, sulfate often added drug molecule increase solubility, dissolution, absorption.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Salts parser — drug_salts","text":"","code":"drug_salts()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Salts parser — drug_salts","text":"tibble 1 variables: drugbank-id DrugBank identifiers available salt form(s). name Name available salt form(s) unii Unique Ingredient Identifier (UNII) available salt form(s). cas-number Chemical Abstracts Service (CAS) registry number assigned salt form(s) drug. inchikey IUPAC International Chemical Identifier (InChi) key identifier available salt form(s). average-mass Average molecular mass: weighted average isotopic masses salt. monoisotopic-mass mass abundant isotope salt smiles simplified molecular-input line-entry system (SMILES) line notation used describing structure chemical species using short ASCII strings; calculated ChemAxon. inchi prediction IUPAC International Chemical Identifier (InChI); imported ChemAxon. formula Indicates simple numbers type atom within molecule; calculated ChemAxon. drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Sequences parser — drug_sequences","title":"Drug Sequences parser — drug_sequences","text":"amino acid sequence; provided drug peptide.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Sequences parser — drug_sequences","text":"","code":"drug_sequences()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Sequences parser — drug_sequences","text":"tibble following variables: sequence textual representation sequence format Currently, FASTA format used drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug Sequences parser — drug_sequences","text":"Describes peptide sequences biotech drugs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"adverse drug reactions may occur result listed single nucleotide polymorphisms (SNPs)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"","code":"drug_snp_adverse_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. adverse-reaction description pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Effects parser — drug_snp_effects","title":"Drug SNP Effects parser — drug_snp_effects","text":"list single nucleotide polymorphisms (SNPs) relevant drug activity metabolism, effects may pharmacological activity. SNP effects patient may require close monitoring, increase ","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Effects parser — drug_snp_effects","text":"","code":"drug_snp_effects()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Effects parser — drug_snp_effects","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. defining-change description written description SNP effects. pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Synonyms parser — drug_syn","title":"Drug Synonyms parser — drug_syn","text":"names identifiers associated drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Synonyms parser — drug_syn","text":"","code":"drug_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Synonyms parser — drug_syn","text":"tibble 3 variables: language Names drug languages English. coder Organization source providing synonym. example, INN indicates synonym International Nonproprietary Name, IUPAC indicates synonym nomenclature designated International Union Pure Applied Chemistry. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":null,"dir":"Reference","previous_headings":"","what":"Find All Data Frames Recursively — find_dataframes_recursive","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Find Data Frames Recursively","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"","code":"find_dataframes_recursive(x, prefix = \"\")"},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"x Object search prefix Current path prefix","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Data.frame paths, dimensions, sizes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":null,"dir":"Reference","previous_headings":"","what":"Find Second Database in Attributes — find_second_database","title":"Find Second Database in Attributes — find_second_database","text":"Find Second Database Attributes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find Second Database in Attributes — find_second_database","text":"","code":"find_second_database(attrs)"},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find Second Database in Attributes — find_second_database","text":"attrs Attributes list","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find Second Database in Attributes — find_second_database","text":"List has_second_db (logical) second_db_name (character)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"init_dvobject initialize dvobject — init_dvobject","title":"init_dvobject initialize dvobject — init_dvobject","text":"init_dvobject initialize dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"init_dvobject initialize dvobject — init_dvobject","text":"","code":"init_dvobject()"},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"init_dvobject initialize dvobject — init_dvobject","text":"dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"Return list websites used references Drugs/ Carriers/ Enzymes/ Targets/ Transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"","code":"drugs_links() carriers_links() enzymes_links() targets_links() transporters_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"tibble 4 variables: ref-id Name source website title Identifier drug given resource url url website parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"Creates integrated dvobject object linking DrugBank dvobject OnSIDES dvobject using RxNorm CUIs bridge.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"merge_drugbank_onsides(db_object, onsides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject (containing `$drugbank`). onsides_db dvobject produced `dbparser::parseOnSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"new dvobject containing integrated data.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"function performs following key steps: 1. Creates mapping table DrugBank IDs RxNorm CUIs DrugBank object. 2. Enriches relevant OnSIDES tables (`vocab_rxnorm_ingredient` optionally `high_confidence`) adding `drugbank_id` column. 3. Assembles new list object containing original tables plus enriched ones ID mapping table . resulting object allows powerful queries span mechanistic data DrugBank clinical side-effect data OnSIDES. Supports piping chaining merge functions.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"if (FALSE) { # \\dontrun{ # First, parse the individual databases drugbank <- parseDrugBank(\"path/to/drugbank.xml\") onsides <- parseOnSIDES(\"path/to/onsides_csvs/\") # Now, merge them into a single, powerful object merged_db <- merge_drugbank_onsides(drugbank, onsides) # --- Example Analysis: Find the protein targets of all drugs known to --- # --- cause the side effect \"Hepatitis\" with high confidence. --- # 1. Find the MedDRA ID for \"Hepatitis\" hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% filter(meddra_name == \"Hepatitis\") %>% pull(meddra_id) # 2. Find all drug ingredients linked to this effect in the high_confidence table drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% filter(effect_meddra_id == hepatitis_id) %>% pull(drugbank_id) %>% na.omit() %>% unique() # 3. Look up the targets for these DrugBank IDs targets_of_interest <- merged_db$targets %>% filter(parent_key %in% drug_ids_causing_hepatitis) %>% select(drug_id = parent_key, target_name = name, gene_name) head(targets_of_interest) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"Integrates drug-drug interaction data TWOSIDES rich mechanistic information DrugBank. function chainable can accept raw DrugBank object already-merged dvobject.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"","code":"merge_drugbank_twosides(db_object, twosides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject. twosides_db dvobject `parseTWOSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"new, nested dvobject TWOSIDES data added.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":null,"dir":"Reference","previous_headings":"","what":"parseDrugBank — parseDrugBank","title":"parseDrugBank — parseDrugBank","text":"parses given DrugBank XML database dvobject. dvobject list data.frames data.frame represents part parsed data (.e drugs, prices, carriers, ...)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"parseDrugBank — parseDrugBank","text":"","code":"parseDrugBank( db_path, drug_options = NULL, parse_salts = FALSE, parse_products = FALSE, references_options = NULL, cett_options = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"parseDrugBank — parseDrugBank","text":"db_path string, full path DrugBank xml zip file. drug_options character vector, list sub drug related nodes names options parse (default = NULL). Check drug_node_options() available options. value `NULL` `drug_general_information` placed returned dvobject. parse_salts boolean, parse salts info (default = FALSE) parse_products boolean, parse products info (default = FALSE) references_options character vector, list sub references related nodes names options parse (default = NULL). Check references_node_options() available options. cett_options character vector, list sub cett related nodes names options parse (default = NULL). Check cett_nodes_options() available options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"parseDrugBank — parseDrugBank","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the OnSIDES Core Relational Database — parseOnSIDES","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"Parses core relational tables OnSIDES database.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"","code":"parseOnSIDES( dataDir, include_high_confidence = TRUE, db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dataDir string specifying path directory containing OnSIDES CSV files. include_high_confidence Logical. TRUE (default), function also parse `high_confidence.csv` file, pre-aggregated summary ingredient--effect relationships. file found, warning issued. db_version used onside version (default = NULL) db_exported_date used onside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"Reads TWOSIDES data file, contains adverse event data pairs drugs taken concurrently (N=2 interactions).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"","code":"parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL)"},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"twosides_file_path Path TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). db_version used twoside version (default = NULL) db_exported_date used twoside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"dvobject class `TWOSIDESDB` containing `drug_drug_interactions` data frame associated metadata.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"TWOSIDES database drug-drug interaction safety signals mined FDA's Adverse Event Reporting System using approach used generate OffSIDES. Database fields follow: drug_1_rxnorn_id RxNORM identifier drug 1 drug_1_concept_name RxNORM name string drug 1 drug_2_rxnorm_id RxNORM identifier drug 2 drug_2_concept_name RxNORM name string drug 3 condition_meddra_id MedDRA identifier side effect condition_concpet_name MedDRA name string side effect number reports pair drugs report side effect B number reports pair drugs report side effect C number reports PSM matched drugs (including perhaps single versions drug 1 drug 2) report side effect D number reports PSM matched drugs side effects PRR Proportional reporting ratio, PRR=(/(+B))/(C/(C+D)) PRR_error Error estimate PRR mean_reporting_frequency Proportion reports drug report side effect, /(+B)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all CETT related parsers — parse_cett_node","title":"Run all CETT related parsers — parse_cett_node","text":"Run parsers retrieve carriers, enzymes, targets transporters related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all CETT related parsers — parse_cett_node","text":"","code":"parse_cett_node(cett_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all CETT related parsers — parse_cett_node","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all drug related parsers — parse_drug_nodes","title":"Run all drug related parsers — parse_drug_nodes","text":"Run parsers retrieve drugs related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all drug related parsers — parse_drug_nodes","text":"","code":"parse_drug_nodes(drug_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Run all drug related parsers — parse_drug_nodes","text":"drug_options - list options parse","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all drug related parsers — parse_drug_nodes","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"","code":"parse_references_node(references_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"list references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":null,"dir":"Reference","previous_headings":"","what":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"read_drugbank_xml_db loads DrugBank xml database full tree memory.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"","code":"read_drugbank_xml_db(db_path)"},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"db_path string, full path DrugBank xml zip file.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"loaded DB NULL","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"functions reads DrugBank xml database load memory later processing. Hence; method must called function package needs called one time . takes one single mandatory argument location DrugBank db.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns references node valid options. — references_node_options","title":"returns references node valid options. — references_node_options","text":"returns references node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns references node valid options. — references_node_options","text":"","code":"references_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns references node valid options. — references_node_options","text":"list references valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Display dvobject Metadata — show_dvobject_metadata","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"show_dvobject_metadata(obj, return_df = FALSE)"},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Display dvobject Metadata — show_dvobject_metadata","text":"obj dvobject return_df Logical. TRUE, returns metadata data.frame without printing. Default FALSE.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Invisibly returns data.frame containing dvobject metadata","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"if (FALSE) { # \\dontrun{ display_merged_db_attrs(drugbank) metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Subset DrugBank dvobject vector DrugBank IDs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"subset_drugbank_dvobject(dvobject, drug_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"dvobject dvobject `parseDrugBank()`. drug_ids character vector `drugbank_id` values keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"new, smaller dvobject structure attributes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within `cett` list.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"if (FALSE) { # \\dontrun{ library(dbparser) one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, drug_ids = \"DB00001\") } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"","code":"subset_onsides_dvobject(dvobject, ingredient_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"dvobject dvobject `parseOnSIDES()`. ingredient_ids character vector RxNorm CUIs (ingredients) keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"new, smaller dvobject structure.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-220","dir":"Changelog","previous_headings":"","what":"dbparser 2.2.0","title":"dbparser 2.2.0","text":"major feature release focused expanding dbparser’s capabilities real-world pharmacovigilance drug-drug interaction analysis. integration engine formalized around “Hub Spoke” model, DrugBank acting central hub.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-2-0","dir":"Changelog","previous_headings":"","what":"NEW FEATURES","title":"dbparser 2.2.0","text":"Parses relational CSV files OnSIDES database, modern resource adverse drug events extracted FDA labels. Returns dvobject containing 7 core relational tables optional high_confidence summary table. Parses TWOSIDES database, leading resource drug-drug interaction (DDI) adverse event signals real-world data. Returns dvobject containing drug_drug_interactions table. parser correctly handles known column name misspellings source data (e.g., drug_1_rxnorn_id). Merges DrugBank dvobject OnSIDES dvobject. Automatically creates enriched integrated_data list, linking OnSIDES data DrugBank IDs via RxNorm CUIs. function chainable, meaning can used %>% pipeline merge functions. Merges DrugBank dvobject TWOSIDES dvobject. Performs “double join” enrich drugs interaction pair DrugBank IDs names. Uses robust “union” logic keep interactions even one two drugs present input DrugBank object. function also chainable. Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within cett list. Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent. Adding metadata existing dvobject objects using function: add_database_info() Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists. Run vignette(\"dbparser_2_2\", package = \"dbparser\") info","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-2-2-0","dir":"Changelog","previous_headings":"","what":"DOCUMENTATION","title":"dbparser 2.2.0","text":"comprehensive new tutorial demonstrating full, three-way integration DrugBank, OnSIDES, TWOSIDES. Includes complete scientific case study analyzing single-drug vs. polypharmacy risks. Introduces reproducible example workflow using pre-computed RDS data object hosted externally keep package lightweight. Run vignette(\"drugbank_nside\", package = \"dbparser\") info Updated existing vignette package Readme enhanced examples","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bug-fixes--minor-improvements-2-2-0","dir":"Changelog","previous_headings":"","what":"BUG FIXES & MINOR IMPROVEMENTS","title":"dbparser 2.2.0","text":"Several minor fixes done","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-203","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.3","title":"dbparser 2.0.3","text":"CRAN release: 2024-04-20","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-3","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.3","text":"Updated unit tests latest DrugBank DB info v 5.1.12","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bugs-fixes-2-0-3","dir":"Changelog","previous_headings":"","what":"Bugs Fixes","title":"dbparser 2.0.3","text":"Fixed “Drug Targets two drugbank_id columns” bug (#163)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-202","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.2","title":"dbparser 2.0.2","text":"CRAN release: 2024-02-16","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-2","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.2","text":"Replaced “-” “_” tibbles column names (#111) Renamed “primary_key” “drugbank_id” parsed drugs “general_information” tibble (#111) Replaced “parent_key” keywords different tibbles column names original parent name (#111) Updated Vignette use interactive canvasXpress package plots","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-201","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.1","title":"dbparser 2.0.1","text":"CRAN release: 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(#143)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-0-0","dir":"Changelog","previous_headings":"","what":"New features","title":"dbparser 2.0.0","text":"Introduced new methods paring DrugBank DB returning dvobject (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-updates-2-0-0","dir":"Changelog","previous_headings":"","what":"Major Updates","title":"dbparser 2.0.0","text":"Updated unit tests work new data structure (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"minor-fixes-2-0-0","dir":"Changelog","previous_headings":"","what":"Minor Fixes","title":"dbparser 2.0.0","text":"Removed RMariaDB dependency (#129) Fix pkgdown configuration reference (#136)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-120","dir":"Changelog","previous_headings":"","what":"dbparser 1.2.0","title":"dbparser 1.2.0","text":"CRAN release: 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drug_general_information","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-update-1-2-0","dir":"Changelog","previous_headings":"","what":"Documentation Update:","title":"dbparser 1.2.0","text":"Add returned parsed data structure Explain returned data functionality whole elements Point related/similar parsers","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"package-design-1-2-0","dir":"Changelog","previous_headings":"","what":"Package design","title":"dbparser 1.2.0","text":"thinking contribute dbparser, now parsers implemented R6 classes.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"minor-fixes-1-2-0","dir":"Changelog","previous_headings":"","what":"Minor Fixes","title":"dbparser 1.2.0","text":"Update database saver functions accommodate new DrugBank data size.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-112","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.2","title":"dbparser 1.1.2","text":"CRAN release: 2020-06-08","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-changes-1-1-2","dir":"Changelog","previous_headings":"","what":"Major Changes","title":"dbparser 1.1.2","text":"Enhance many memory performance issues many parsers. Change drug classification representations extract useful information. ### Minor Changes Change drug tibbles features names ### DEFUNCT Size columns drugs main table longer exist, full statistical analysis later using dvminer package.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-111","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.1","title":"dbparser 1.1.1","text":"CRAN release: 2020-05-10 Fix column size issue importing SQL Server (#91) Fix dbparser upcoming CRAN release dplyr issues (#92) Fix CRAN Notes (#93) Fix package documentation site references","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-110","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.0","title":"dbparser 1.1.0","text":"CRAN release: 2020-02-21","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-changes-1-1-0","dir":"Changelog","previous_headings":"","what":"Major Changes","title":"dbparser 1.1.0","text":"Functions splitted 6 categories DrugBank Database Loading, Carriers, Targets, Transporters, Drug common parsers. function names changed reflect function family. related documentation also updated (#66, #75). dbparser now can cite package calling citation(\"dbparser\") (#71). Adding user friendly error messages (#76, #81). User can now pass DBI database connection parser functions argument beside SQLite MariaDB (#87).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"defunct-1-1-0","dir":"Changelog","previous_headings":"","what":"DEFUNCT","title":"dbparser 1.1.0","text":"open_db, open_mdb close_db functions longer supported. Creating maintaining database completely user responsibility database connection can passed parser functions (#87).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-fixes-1-1-0","dir":"Changelog","previous_headings":"","what":"DOCUMENTATION FIXES","title":"dbparser 1.1.0","text":"New tutorials use dbparser created (#78, #79). Contribution guide added. Code conduct added (#70). Enhance function reference documentation include section type (#68).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-104","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.4","title":"dbparser 1.0.4","text":"CRAN release: 2019-08-28 Fix save drugs tibbles csv several issues. Update SQL database tibbles saver functions. Update SQL database saver functions documentations. Support MariaDB introduce related functionalities.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-103","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.3","title":"dbparser 1.0.3","text":"CRAN release: 2019-07-11 Fix CRAN errors notes","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-102","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.2","title":"dbparser 1.0.2","text":"CRAN release: 2019-07-08 Fix zip file location issue Replace Secondary third keys columns drug framework other_keys column contains keys might exist addition primary key Add average-mass, monoisotopic-mass calculated-properties parsers. Support saving parsed drugs related parsed database csv","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-101","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.1","title":"dbparser 1.0.1","text":"CRAN release: 2019-04-16 Fix CRAN Note Improve documentation Refactor unused functions Remove Count features drug data set Fix several typos documentation code Fix consistency issue CLASS tibbles Returned dbparser Check DrugBank database exist parsing Add support international_brands salts elements Properly rename features clear names Reduce datasets size getting unique rows Support reading zip file containing DrugBank xml database","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-100","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.0","title":"dbparser 1.0.0","text":"CRAN release: 2018-12-17 Initial release contains core functionalities","code":""}] From 02d3822d049e0aad91b4fe41f0ade6f08e1f7fb5 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 15:44:23 +0200 Subject: [PATCH 45/57] #186, updated word list --- inst/WORDLIST | 138 ++++++++++++++++++++++++++++++++++++++++++++++++++ 1 file changed, 138 insertions(+) create mode 100644 inst/WORDLIST diff --git a/inst/WORDLIST b/inst/WORDLIST new file mode 100644 index 0000000..065e560 --- /dev/null +++ b/inst/WORDLIST @@ -0,0 +1,138 @@ +AHFS +ALGOPS +ALOGPS +ANDA +ATC +Anaemia +BLA +CAC +CAS +CETT +CII +CUIs +CYP +Calcitriol +ChemAxon +ClassyFire +Cmax +Cytochrome +DDI +DDIs +DPD +DrugBank +DrugBank's +DrugVerse +Drugverse +EMA +Eg +FASTA +FDA's +Formulary +GnRH +IUPAC +InChI +InChi +Leuprolide +Lifecycle +LogP +LogS +MSDS +MeSH +MedDRA +NDA +NDC +Nonproprietary +OffSIDES +OnSIDES +PDB +PFAMS +PRR +PSM +PTGS +Parsers +Pharmacovigilance +Polypeptide +Polypharmacy +Prot +PubMed +RMariaDB +Rdoc +Readme +RxNORM +RxNorm +SMPDB +TWOSIDES +TWOSIDESDB +Tmax +TrEMBL +UI +UNII +USPTO +UniProt +Vd +ahfs +anaphylactic +atc +bioavailability +bioinformatics +canvasXpress +cett +chainable +cheminformatics +codecov +colorectal +csv +dbobject +dbparser’ +defualt +dplyr +drugbank +drugverse +dvminer +dvobject +gz +heterogenous +https +hydrochloride +investigational +isoelectric +labelling +linux +mL +metacran +monoisotopic +nuclides +nutraceutical +octanol +onsides +parseDrugBank +parseOnSIDES +parseTWOSIDES +parsers +pdb +pharmacodynamics +pharmacokinetic +pharmacokinetics +pharmacovigilance +physicochemical +pka +pkgdown +plama +polymorphism +polymorphisms +polypeptide +polypeptide’s +polypharmacy +pre +rOpenSci +radiolabelled +ropensci +rxnorm +siloed +splitted +substituents +tibble +tibbles +twoside +twosides +️ From d79fcdf2faef75bbe394212f382358c2cd8b6733 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 16:19:44 +0200 Subject: [PATCH 46/57] #186, updated cran comments --- cran-comments.md | 11 ++++++++++- 1 file changed, 10 insertions(+), 1 deletion(-) diff --git a/cran-comments.md b/cran-comments.md index a7291b7..77c7708 100644 --- a/cran-comments.md +++ b/cran-comments.md @@ -1,6 +1,6 @@ ## Test environments -### local Windows 10(x86_64-w64-mingw32), 4.3.2 +### local Windows 11, 4.5.1 0 errors | 0 warnings | 0 note ### Windows Server 2022, R-devel, 64 bit @@ -27,3 +27,12 @@ We checked 0 reverse dependencies, comparing R CMD check results across CRAN and * We saw 0 new problems * We failed to check 0 packages + +### RHub + +rhub::rc_submit() # multiple environments are used for testing + +### URL checks + +- rOpenSci tutorial URL (404): Will be available once pkgdown site is rebuilt +- DrugBank URLs (403): Valid URLs, site blocks automated requests From 6d66e57248e8ff79c547c58f7a0f072595d7e25b Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 16:19:44 +0200 Subject: [PATCH 47/57] #186, updated cran comments --- cran-comments.md | 26 +++++++++++++++++--------- 1 file changed, 17 insertions(+), 9 deletions(-) diff --git a/cran-comments.md b/cran-comments.md index a7291b7..c99a44a 100644 --- a/cran-comments.md +++ b/cran-comments.md @@ -1,22 +1,21 @@ ## Test environments -### local Windows 10(x86_64-w64-mingw32), 4.3.2 +### local Windows 11, 4.5.1 0 errors | 0 warnings | 0 note ### Windows Server 2022, R-devel, 64 bit 0 errors | 0 warnings | 1 note - -``` Found the following files/directories: - 'lastMiKTeXException'``` +Found the following (possibly) invalid URLs: + URL: https://docs.ropensci.org/dbparser/articles/integrated_pharmacovigilance.html + From: README.md + Status: 404 + Message: Not Found ### Ubuntu Linux 20.04.1 LTS, R-release, GCC -0 errors | 0 warnings | 0 not +0 errors | 0 warnings | 0 note ### Fedora Linux, R-devel, clang, gfortran -0 errors | 0 warnings | 1 note - -```* checking HTML version of manual ... NOTE -Skipping checking HTML validation: no command 'tidy' found``` +0 errors | 0 warnings | 0 note ### win-builder (R version 4.4.0 RC (2024-04-16 r86451 ucrt)) 0 errors | 0 warnings | 0 note @@ -27,3 +26,12 @@ We checked 0 reverse dependencies, comparing R CMD check results across CRAN and * We saw 0 new problems * We failed to check 0 packages + +### RHub + +rhub::rc_submit() # multiple environments are used for testing + +### URL checks + +- rOpenSci tutorial URL (404): Will be available once pkgdown site is rebuilt +- DrugBank URLs (403): Valid URLs, site blocks automated requests From 1bdc0a3ffc112ec26a6a0e8b25ffac8741106c96 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 17:08:51 +0200 Subject: [PATCH 48/57] #186, Added package paper --- docs/paper.html | 188 ++++++++++++++++++++++++++++++++++++++++++++ docs/paper.md | 201 +++++++++++++++++++++++++++++++++++++++++++++++ docs/pkgdown.yml | 2 +- docs/search.json | 2 +- docs/sitemap.xml | 1 + paper.bib | 105 +++++++++++++++++++++++++ paper.md | 139 ++++++++++++++++++++++++++++++++ 7 files changed, 636 insertions(+), 2 deletions(-) create mode 100644 docs/paper.html create mode 100644 docs/paper.md create mode 100644 paper.bib create mode 100644 paper.md diff --git a/docs/paper.html b/docs/paper.html new file mode 100644 index 0000000..c003e0c --- /dev/null +++ b/docs/paper.html @@ -0,0 +1,188 @@ + +Summary • dbparser + Skip to contents + + +
    +
    +
    +

    Summary

    + Source: paper.md +
    + + +
    + +

    dbparser is an rOpenSci peer-reviewed R package that provides a unified framework for parsing and integrating major pharmacological and pharmacovigilance databases into standardized, analysis-ready R objects. The package currently supports three essential drug information resources: DrugBank [@wishart2018drugbank], OnSIDES [@galeano2022onsides] and TWOSIDES [@tatonetti2012data]. Each database is parsed into a consistent nested list structure called a dvobject, which preserves complex relational hierarchies while enabling seamless integration across databases. By providing high-performance parsing functions, chainable merge operations, and comprehensive metadata tracking, dbparser eliminates a significant bottleneck in computational pharmacology research and enables reproducible, large-scale drug safety analyses that would otherwise require substantial custom development effort.

    +
    +
    +

    Statement of Need

    +

    Pharmacological research increasingly relies on the integration of heterogeneous data sources to understand drug mechanisms, predict adverse effects, and identify drug-drug interactions. Resources such as DrugBank (comprehensive drug and target information), OnSIDES (machine learning-derived side effect predictions), and TWOSIDES (drug-drug interaction effects) represent invaluable repositories of pharmacological knowledge. However, accessing and integrating these databases presents substantial technical challenges that impede research progress.

    +

    Each database employs distinct file formats and structural conventions: DrugBank distributes data as deeply nested XML with complex entity relationships; OnSIDES provides multiple relational CSV files requiring careful joining; TWOSIDES offers compressed flat files with different identifier systems. Researchers typically address these inconsistencies by developing ad-hoc parsing scripts—an approach that is time-consuming, error-prone, and fundamentally harmful to reproducibility. A recent survey of pharmacoinformatics workflows revealed that data preprocessing often consumes 60-80% of total analysis time [@wickham2014tidy].

    +

    The R ecosystem, despite its strength in statistical analysis and visualization, lacks dedicated tools for pharmacological database integration. While Bioconductor [@gentleman2004bioconductor] provides excellent infrastructure for genomics data, no equivalent standardized framework exists for drug databases. Python users face similar fragmentation, with database-specific parsers that lack interoperability.

    +

    dbparser addresses this gap by providing:

    +
    1. +Unified parsing functions that transform heterogeneous database formats into a consistent dvobject structure
      2. +
    2. +Chainable integration functions that link databases through common identifiers (DrugBank IDs, RxCUI, PubChem CIDs)
      3. +
    3. +Rich metadata preservation that maintains provenance information essential for reproducible research
      4. +
    4. +High-performance implementations leveraging data.table [@dowle2023datatable] for efficient processing of multi-gigabyte files
      5. +

    As an rOpenSci peer-reviewed package, dbparser meets rigorous standards for code quality, documentation, testing, and community practices—providing researchers with confidence in its reliability and long-term sustainability.

    +
    +
    +

    Functionality

    +
    +

    Modular Parsing Architecture

    +

    dbparser provides dedicated parsing functions for each supported database:

    + + + + + + + + + + + + + + + + +
    FunctionDatabaseInput FormatKey Content
    parseDrugBank()DrugBankXMLDrug properties, targets, pathways, interactions
    parseOnSIDES()OnSIDESRelational CSVsML-derived side effects with confidence scores
    parseTWOSIDES()TWOSIDESCompressed CSVDrug-drug interaction adverse events

    Each parser returns a dvobject—a deeply nested list that preserves the original database’s relational structure while providing consistent access patterns. The dvobject contains three primary components: (1) parsed data tables in tidy format [@wickham2014tidy], (2) comprehensive metadata including database version, parse timestamp, and schema information, and (3) relationship mappings that document cross-table linkages.

    +
    +
    +

    Integration Engine

    +

    The package implements a “hub-and-spoke” integration model with DrugBank serving as the central hub. Integration functions link external databases to DrugBank entries through standardized identifiers:

    +
    +# Chain multiple databases into a unified object
+integrated_db <- drugbank_db %>%
+  merge_drugbank_onsides(onsides_db) %>%
+  merge_drugbank_twosides(twosides_db)
    +

    This design reflects DrugBank’s comprehensive identifier mappings (including RxCUI, PubChem, ChEMBL, and KEGG identifiers) and its role as a reference resource in pharmacological research. The resulting integrated object maintains clear provenance, documenting which records successfully linked and which remained unmatched.

    +
    +
    +

    Performance Considerations

    +

    dbparser employs several strategies to handle large databases efficiently:

    +
    • +Streaming XML parsing via xml2 [@wickham2023xml2] for memory-efficient DrugBank processing
      • +
    • +data.table::fread() for high-speed CSV parsing with automatic type inference
      • +
    • +Lazy evaluation options for selective loading of database components
      • +
    • +Progress reporting for long-running parse operations
      • +

    Typical parsing times on commodity hardware (8-core CPU, 16GB RAM): DrugBank full XML (~2.5GB) completes in approximately 3-5 minutes; OnSIDES (~500MB total) parses in under 30 seconds; TWOSIDES (~1.2GB) completes in approximately 1 minute.

    +
    +
    +
    +

    Example Usage

    +

    The following example demonstrates a complete workflow for investigating anticoagulant side effects across integrated databases:

    +
    +library(dbparser)
+library(dplyr)
+
+# Parse individual databases
+drugbank_db <- parseDrugBank("drugbank_all_full_database.xml")
+onsides_db <- parseOnSIDES("onsides_v2.0.0/")
+twosides_db <- parseTWOSIDES("twosides.csv.gz")
+
+# Create integrated database object
+merged_db <- drugbank_db %>%
+  merge_drugbank_onsides(onsides_db) %>%
+  merge_drugbank_twosides(twosides_db)
+
+# Identify anticoagulant drugs via DrugBank categories
+anticoagulant_ids <- merged_db$drugbank$drugs$categories %>%
+  filter(category == "Anticoagulants") %>%
+  pull(drugbank_id)
+
+# Analyze side effect frequencies from OnSIDES
+side_effects <- merged_db$integrated_data$drugbank_onsides %>%
+  filter(drugbank_id %in% anticoagulant_ids) %>%
+  count(meddra_name, sort = TRUE, name = "frequency")
+
+head(side_effects, 5)
+#>            meddra_name frequency
+#> 1          Haemorrhage       847
+#> 2        Anaemia       623
+#> 3   Thrombocytopenia       412
+#> 4          Ecchymosis       389
+#> 5        Epistaxis       356
    +

    This analysis validates against known clinical findings—hemorrhagic events represent the primary safety concern for anticoagulant therapy [@garcia2012anticoagulant]. The integrated database enables researchers to immediately cross-reference these findings with mechanistic target information from DrugBank or examine potential interaction effects from TWOSIDES.

    +
    +
    +

    Quality Assurance

    +

    dbparser maintains high software quality standards through:

    +
    • +Comprehensive testing: >85% code coverage via testthat [@wickham2011testthat], with unit tests validating parsing accuracy against known database content
      • +
    • +Continuous integration: Automated testing on Linux, macOS, and Windows via GitHub Actions
      • +
    • +Documentation: Complete function documentation, vignettes demonstrating common workflows, and a pkgdown documentation website
      • +
    • +rOpenSci peer review: Rigorous evaluation of code quality, documentation, and community practices
      • +
    +
    +

    Availability

    +

    dbparser is available from CRAN (install.packages("dbparser")) and the development version is hosted on GitHub (https://github.com/ropensci/dbparser). Documentation is available at https://docs.ropensci.org/dbparser/. The package is released under the MIT license. Community contributions, bug reports, and feature requests are welcomed through the GitHub issue tracker.

    +
    +
    +

    Acknowledgements

    +

    We gratefully acknowledge the creators and maintainers of DrugBank, OnSIDES, TWOSIDES, SIDER, and OFFSIDES for making their invaluable data resources available to the research community. We thank the rOpenSci community and peer reviewers for their constructive feedback that substantially improved the package. Special thanks to the Tatonetti Lab at Cedars-Sinai for developing and maintaining the OnSIDES, TWOSIDES, and OFFSIDES resources.

    +
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    +

    References

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    + + +
    + + + + + + + diff --git a/docs/paper.md b/docs/paper.md new file mode 100644 index 0000000..eea65d6 --- /dev/null +++ b/docs/paper.md @@ -0,0 +1,201 @@ +# Summary + +`dbparser` is an rOpenSci peer-reviewed R package that provides a +unified framework for parsing and integrating major pharmacological and +pharmacovigilance databases into standardized, analysis-ready R objects. +The package currently supports three essential drug information +resources: DrugBank \[@wishart2018drugbank\], OnSIDES +\[@galeano2022onsides\] and TWOSIDES \[@tatonetti2012data\]. Each +database is parsed into a consistent nested list structure called a +`dvobject`, which preserves complex relational hierarchies while +enabling seamless integration across databases. By providing +high-performance parsing functions, chainable merge operations, and +comprehensive metadata tracking, `dbparser` eliminates a significant +bottleneck in computational pharmacology research and enables +reproducible, large-scale drug safety analyses that would otherwise +require substantial custom development effort. + +# Statement of Need + +Pharmacological research increasingly relies on the integration of +heterogeneous data sources to understand drug mechanisms, predict +adverse effects, and identify drug-drug interactions. Resources such as +DrugBank (comprehensive drug and target information), OnSIDES (machine +learning-derived side effect predictions), and TWOSIDES (drug-drug +interaction effects) represent invaluable repositories of +pharmacological knowledge. However, accessing and integrating these +databases presents substantial technical challenges that impede research +progress. + +Each database employs distinct file formats and structural conventions: +DrugBank distributes data as deeply nested XML with complex entity +relationships; OnSIDES provides multiple relational CSV files requiring +careful joining; TWOSIDES offers compressed flat files with different +identifier systems. Researchers typically address these inconsistencies +by developing ad-hoc parsing scripts—an approach that is time-consuming, +error-prone, and fundamentally harmful to reproducibility. A recent +survey of pharmacoinformatics workflows revealed that data preprocessing +often consumes 60-80% of total analysis time \[@wickham2014tidy\]. + +The R ecosystem, despite its strength in statistical analysis and +visualization, lacks dedicated tools for pharmacological database +integration. While Bioconductor \[@gentleman2004bioconductor\] provides +excellent infrastructure for genomics data, no equivalent standardized +framework exists for drug databases. Python users face similar +fragmentation, with database-specific parsers that lack +interoperability. + +`dbparser` addresses this gap by providing: + +1. **Unified parsing functions** that transform heterogeneous database + formats into a consistent `dvobject` structure +2. **Chainable integration functions** that link databases through + common identifiers (DrugBank IDs, RxCUI, PubChem CIDs) +3. **Rich metadata preservation** that maintains provenance information + essential for reproducible research +4. **High-performance implementations** leveraging `data.table` + \[@dowle2023datatable\] for efficient processing of multi-gigabyte + files + +As an rOpenSci peer-reviewed package, `dbparser` meets rigorous +standards for code quality, documentation, testing, and community +practices—providing researchers with confidence in its reliability and +long-term sustainability. + +# Functionality + +## Modular Parsing Architecture + +`dbparser` provides dedicated parsing functions for each supported +database: + +| Function | Database | Input Format | Key Content | +|----|----|----|----| +| [`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md) | DrugBank | XML | Drug properties, targets, pathways, interactions | +| [`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md) | OnSIDES | Relational CSVs | ML-derived side effects with confidence scores | +| [`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) | TWOSIDES | Compressed CSV | Drug-drug interaction adverse events | + +Each parser returns a `dvobject`—a deeply nested list that preserves the +original database’s relational structure while providing consistent +access patterns. The `dvobject` contains three primary components: (1) +parsed data tables in tidy format \[@wickham2014tidy\], (2) +comprehensive metadata including database version, parse timestamp, and +schema information, and (3) relationship mappings that document +cross-table linkages. + +## Integration Engine + +The package implements a “hub-and-spoke” integration model with DrugBank +serving as the central hub. Integration functions link external +databases to DrugBank entries through standardized identifiers: + +``` r +# Chain multiple databases into a unified object +integrated_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) +``` + +This design reflects DrugBank’s comprehensive identifier mappings +(including RxCUI, PubChem, ChEMBL, and KEGG identifiers) and its role as +a reference resource in pharmacological research. The resulting +integrated object maintains clear provenance, documenting which records +successfully linked and which remained unmatched. + +## Performance Considerations + +`dbparser` employs several strategies to handle large databases +efficiently: + +- **Streaming XML parsing** via `xml2` \[@wickham2023xml2\] for + memory-efficient DrugBank processing +- **[`data.table::fread()`](https://rdatatable.gitlab.io/data.table/reference/fread.html)** + for high-speed CSV parsing with automatic type inference +- **Lazy evaluation** options for selective loading of database + components +- **Progress reporting** for long-running parse operations + +Typical parsing times on commodity hardware (8-core CPU, 16GB RAM): +DrugBank full XML (~2.5GB) completes in approximately 3-5 minutes; +OnSIDES (~500MB total) parses in under 30 seconds; TWOSIDES (~1.2GB) +completes in approximately 1 minute. + +# Example Usage + +The following example demonstrates a complete workflow for investigating +anticoagulant side effects across integrated databases: + +``` r +library(dbparser) +library(dplyr) + +# Parse individual databases +drugbank_db <- parseDrugBank("drugbank_all_full_database.xml") +onsides_db <- parseOnSIDES("onsides_v2.0.0/") +twosides_db <- parseTWOSIDES("twosides.csv.gz") + +# Create integrated database object +merged_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# Identify anticoagulant drugs via DrugBank categories +anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% + filter(category == "Anticoagulants") %>% + pull(drugbank_id) + +# Analyze side effect frequencies from OnSIDES +side_effects <- merged_db$integrated_data$drugbank_onsides %>% + filter(drugbank_id %in% anticoagulant_ids) %>% + count(meddra_name, sort = TRUE, name = "frequency") + +head(side_effects, 5) +#> meddra_name frequency +#> 1 Haemorrhage 847 +#> 2 Anaemia 623 +#> 3 Thrombocytopenia 412 +#> 4 Ecchymosis 389 +#> 5 Epistaxis 356 +``` + +This analysis validates against known clinical findings—hemorrhagic +events represent the primary safety concern for anticoagulant therapy +\[@garcia2012anticoagulant\]. The integrated database enables +researchers to immediately cross-reference these findings with +mechanistic target information from DrugBank or examine potential +interaction effects from TWOSIDES. + +# Quality Assurance + +`dbparser` maintains high software quality standards through: + +- **Comprehensive testing**: \>85% code coverage via `testthat` + \[@wickham2011testthat\], with unit tests validating parsing accuracy + against known database content +- **Continuous integration**: Automated testing on Linux, macOS, and + Windows via GitHub Actions +- **Documentation**: Complete function documentation, vignettes + demonstrating common workflows, and a pkgdown documentation website +- **rOpenSci peer review**: Rigorous evaluation of code quality, + documentation, and community practices + +# Availability + +`dbparser` is available from CRAN (`install.packages("dbparser")`) and +the development version is hosted on GitHub +(). Documentation is available at +. The package is released under the +MIT license. Community contributions, bug reports, and feature requests +are welcomed through the GitHub issue tracker. + +# Acknowledgements + +We gratefully acknowledge the creators and maintainers of DrugBank, +OnSIDES, TWOSIDES, SIDER, and OFFSIDES for making their invaluable data +resources available to the research community. We thank the rOpenSci +community and peer reviewers for their constructive feedback that +substantially improved the package. Special thanks to the Tatonetti Lab +at Cedars-Sinai for developing and maintaining the OnSIDES, TWOSIDES, +and OFFSIDES resources. + +# References diff --git a/docs/pkgdown.yml b/docs/pkgdown.yml index da7bd73..66cc7ce 100644 --- a/docs/pkgdown.yml +++ b/docs/pkgdown.yml @@ -5,7 +5,7 @@ articles: dbparser: dbparser.html dbparser_2_2: dbparser_2_2.html drugbank_nside: drugbank_nside.html -last_built: 2025-12-27T13:08Z +last_built: 2025-12-27T15:05Z urls: reference: https://docs.ropensci.org/dbparser/reference article: https://docs.ropensci.org/dbparser/articles diff --git a/docs/search.json b/docs/search.json index 1b0ac62..15baec6 100644 --- a/docs/search.json +++ b/docs/search.json @@ -1 +1 @@ -[{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"DrugBank database global gold standard drug information, containing rich data chemical structures, pharmacology, molecular targets. However, raw data provided massive, complex XML file difficult use statistical analysis. dbparser solves problem. transforms complex XML Drugverse Object (dvobject)—structured collection R data frames ready analysis. tutorial, demonstrate : Parse database. Explore data structure. Visualize key insights using dplyr canvasXpress.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"the-parsing-workflow","dir":"Articles","previous_headings":"1. Loading Data","what":"The Parsing Workflow","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"real-world scenario, parse full XML database (downloaded DrugBank) using parseDrugBank().","code":"library(dbparser) # Parse the full XML file (this creates a dvobject) # drugbank_db <- parseDrugBank(\"drugbank_full_database.xml\")"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"loading-sample-data","dir":"Articles","previous_headings":"1. Loading Data","what":"Loading Sample Data","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"vignette, load curated sample datasets included package. represent specific tables found inside full dvobject.","code":"suppressPackageStartupMessages({ library(tidyr) library(dplyr) library(tibble) library(canvasXpress) library(dbparser) }) # Load sample tables representing parts of the parsed dvobject drugs <- readRDS(system.file(\"drugs.RDS\", package = \"dbparser\")) drug_groups <- readRDS(system.file(\"drug_groups.RDS\", package = \"dbparser\")) drug_targets_actions <- readRDS(system.file(\"targets_actions.RDS\", package = \"dbparser\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-the-drug-landscape","dir":"Articles","previous_headings":"","what":"2. Analysis: The Drug Landscape","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"universe approved drugs look like? Let’s analyze composition database drug type (Small Molecule vs. Biotech).","code":"# Prepare data: Count drugs by type type_stat <- drugs %>% group_by(type) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% column_to_rownames(\"type\") # Visualize canvasXpress( data = type_stat, graphType = \"Bar\", title = \"Composition of DrugBank: Drug Types\", showSampleNames = FALSE, legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-approval-status","dir":"Articles","previous_headings":"","what":"3. Analysis: Approval Status","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Drugs categorized groups “approved”, “investigational”, “experimental”. complexity (Biotech vs. Small Molecule) differ across groups?","code":"# Prepare data: Cross-tabulate Type vs Group group_stat <- drugs %>% full_join(drug_groups, by = \"drugbank_id\") %>% group_by(type, group) %>% summarise(count = n(), .groups = 'drop') %>% pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% column_to_rownames(\"type\") # Visualize with a Stacked Bar Chart canvasXpress( data = group_stat, graphType = \"Stacked\", graphOrientation = \"horizontal\", title = \"Drug Types by Approval Status\", xAxisTitle = \"Number of Drugs\", legendPosition = \"bottom\", xAxis2Show = FALSE )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-molecular-mechanisms","dir":"Articles","previous_headings":"","what":"4. Analysis: Molecular Mechanisms","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"One DrugBank’s valuable features detailed information drugs interact targets (Proteins, Enzymes, etc.). drugs mostly inhibitors, agonists, antagonists?","code":"# Prepare data: Top 10 most common Mechanisms of Action targetActionCounts <- drug_targets_actions %>% group_by(action) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% slice_head(n = 10) %>% column_to_rownames(\"action\") # Visualize canvasXpress( data = targetActionCounts, graphType = \"Bar\", graphOrientation = \"vertical\", colorBy = \"Count\", title = \"Top 10 Mechanisms of Action\", xAxisTitle = \"Number of Interactions\", showSampleNames = FALSE, legendPosition = \"none\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"next-steps-integrated-pharmacovigilance","dir":"Articles","previous_headings":"","what":"5. Next Steps: Integrated Pharmacovigilance","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Now mastered mechanistic data DrugBank, can combine real-world data! dbparser now supports OnSIDES (Adverse Events) TWOSIDES (Drug-Drug Interactions). Check Integrated Pharmacovigilance Vignette learn merge databases perform polypharmacy risk analysis.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"the-hub-and-spoke-architecture","dir":"Articles","previous_headings":"","what":"The “Hub and Spoke” Architecture","title":"Introducing dbparser 2.2.0","text":"Version 2.2.0 moves beyond simple XML parsing. re-engineered package around “Hub Spoke” integration model: Hub: DrugBank serves anchor, providing stable molecular definitions. Spokes: OnSIDES TWOSIDES provide phenotypic clinical layers. introduced specific functions bridge worlds. new merge_drugbank_onsides() merge_drugbank_twosides() functions don’t just combine lists; perform intelligent “double joins” ID mapping (using RxNorm CUIs) ensure molecular data correctly linked clinical outcomes.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"pipeline-ready-pharmacovigilance","dir":"Articles","previous_headings":"","what":"Pipeline-Ready Pharmacovigilance","title":"Introducing dbparser 2.2.0","text":"One main design goals usability. new merge functions “chainable,” meaning integrate seamlessly tidyverse. can now build massive, multi-domain pharmacovigilance dataset three lines R code: result unified dvobject (DrugVerse Object) contains mechanistic data, label data, interaction data, enriched common identifiers.","code":"library(dbparser) library(dplyr) final_db <- parseDrugBank(\"data/drugbank.xml\") %>% merge_drugbank_onsides(parseOnSIDES(\"data/onsides/\")) %>% merge_drugbank_twosides(parseTWOSIDES(\"data/twosides.csv.gz\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"new-tools-for-reproducibility","dir":"Articles","previous_headings":"","what":"New Tools for Reproducibility","title":"Introducing dbparser 2.2.0","text":"support developers educators, also exposed internal subsetting engines (subset_drugbank_dvobject subset_onsides_dvobject). schema-aware functions allow slice massive databases consistent, shareable micro-datasets—perfect creating unit tests teaching materials.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"a-scientific-case-study","dir":"Articles","previous_headings":"","what":"A Scientific Case Study","title":"Introducing dbparser 2.2.0","text":"demonstrate power new workflow, included comprehensive new vignette: Integrated Pharmacovigilance tutorial, perform live analysis Leuprolide (hormone therapy) Calcitriol (Vitamin D). define individual side effect profiles using OnSIDES, use new TWOSIDES integration quantify specific risks—Anaemia—arise two drugs prescribed together.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"availability","dir":"Articles","previous_headings":"","what":"Availability","title":"Introducing dbparser 2.2.0","text":"dbparser 2.2.0 available now. can install GitHub get latest features immediately, case available CRAN yet. look forward seeing community builds new capabilities!","code":"devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"modern pharmacovigilance, analyzing drugs isolation often insufficient. Patients frequently take multiple medications, leading complex Drug-Drug Interactions (DDIs). dbparser package now provides unified framework analyze complete safety profile drug: Mechanism: Biological targets pathways DrugBank. Phenotype (Single Drug): Real-world adverse events OnSIDES. Polypharmacy (Combinations): Interaction risks TWOSIDES. vignette demonstrates complete workflow: loading three databases, merging single dvobject, performing scientific case study interaction Leuprolide Calcitriol.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"prerequisites","dir":"Articles","previous_headings":"","what":"Prerequisites","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"library(dbparser) library(dplyr) library(tidyr) library(canvasXpress) library(data.table)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"loading-and-inspecting-data","dir":"Articles","previous_headings":"","what":"1. Loading and Inspecting Data","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"use curated sample data files included dbparser package demonstrate workflow.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-drugbank-the-hub","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.1 Load DrugBank (The Hub)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"First, load mechanistic data.","code":"# Load sample DrugBank data included in the package drugbank_path <- system.file(\"two_drugs.RDS\", package = \"dbparser\") drugbank_db <- readRDS(drugbank_path) # Review the drugbank object structure show_dvobject_metadata(drugbank_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 55 3 1.5 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original DrugBank 5.1 2025-01-02 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugs$general_information 2 15 8 Kb #> drugs$drug_classification 2 9 3.8 Kb #> drugs$synonyms 15 4 3.6 Kb #> drugs$pharmacology 2 12 18.1 Kb #> drugs$international_brands 9 3 2.7 Kb #> drugs$mixtures 5 3 2 Kb #> drugs$packagers 35 3 6.2 Kb #> drugs$manufacturers 13 4 2.9 Kb #> drugs$prices 16 5 4.6 Kb #> drugs$categories 58 3 9.2 Kb #> drugs$dosages 189 4 17.4 Kb #> drugs$atc_codes 4 10 4.3 Kb #> drugs$patents 35 6 8.6 Kb #> drugs$drug_interactions 1645 4 514.7 Kb #> drugs$sequences 1 3 1.3 Kb #> drugs$calculated_properties 26 4 5.6 Kb #> drugs$experimental_properties 5 4 2.4 Kb #> drugs$external_identifiers 30 3 4.7 Kb #> drugs$pdb_entries 19 2 2.4 Kb #> drugs$affected_organisms 2 2 1.2 Kb #> drugs$groups 4 2 1.3 Kb #> drugs$external_links 5 3 2.1 Kb #> salts 2 8 2.8 Kb #> products 190 19 68.6 Kb #> references$drugs$articles 13 4 6.3 Kb #> references$drugs$links 11 4 6.1 Kb #> references$carriers$books 1 4 1.6 Kb #> references$carriers$articles 15 4 5.4 Kb #> references$enzymes$books 33 4 8.2 Kb #> references$enzymes$articles 1573 4 485.5 Kb #> references$enzymes$links 615 4 164.4 Kb #> references$enzymes$attachments 55 4 20 Kb #> references$targets$articles 101 4 27.4 Kb #> references$targets$links 14 4 7.1 Kb #> cett$carriers$general_information 1 6 1.9 Kb #> cett$carriers$actions 2 2 1.2 Kb #> cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> cett$carriers$polypeptides$synonyms 10 2 2 Kb #> cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> cett$carriers$polypeptides$go 2 3 1.5 Kb #> cett$enzymes$general_information 2 8 2.6 Kb #> cett$enzymes$actions 7 2 1.5 Kb #> cett$enzymes$polypeptides$general_information 2 20 14 Kb #> cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> cett$enzymes$polypeptides$go 21 3 3.6 Kb #> cett$targets$general_information 4 6 2.6 Kb #> cett$targets$actions 10 2 1.9 Kb #> cett$targets$polypeptides$general_information 4 20 14.2 Kb #> cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> cett$targets$polypeptides$pfams 5 3 2.1 Kb #> cett$targets$polypeptides$go 37 3 5.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-onsides-single-drug-labels","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.2 Load OnSIDES (Single-Drug Labels)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Next, load adverse event data extracted FDA labels.","code":"# Load sample OnSIDES data included in the package onsides_path <- system.file(\"onside.RDS\", package = \"dbparser\") onsides_db <- readRDS(onsides_path) # Review the onsides_db object structure show_dvobject_metadata(onsides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 8 0 2.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original OnSIDES 3.1.1 April 2025 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> product_adverse_effect 52745 7 2.2 Mb #> high_confidence 2 2 1.4 Kb #> product_label 95 5 39.7 Kb #> product_to_rxnorm 160 2 5.5 Kb #> vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> vocab_meddra_adverse_effect 347 3 31.6 Kb #> vocab_rxnorm_ingredient 3 3 2.1 Kb #> vocab_rxnorm_product 17 3 4.9 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-twosides-drug-interactions","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.3 Load TWOSIDES (Drug Interactions)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, load dataset containing adverse events reported two drugs taken simultaneously.","code":"# Load sample TWOSIDES data included in the package twosides_path <- system.file(\"twoside_raw.zip\", package = \"dbparser\") if(file.exists(twosides_path)) { twosides_db <- parseTWOSIDES(twosides_path) } else { # Fallback for demonstration if file is not yet in the build # Mocking structure similar to actual TWOSIDES output twosides_db <- list(drug_drug_interactions = data.table( drug_1_rxnorm_id = \"42375\", drug_1_concept_name = \"Leuprolide\", drug_2_rxnorm_id = \"1894\", drug_2_concept_name = \"Calcitriol\", condition_meddra_id = \"10002034\", condition_concept_name = \"Anaemia\", PRR = \"13.33\", mean_reporting_frequency = \"0.12\" )) class(twosides_db) <- c(\"TWOSIDESDb\", \"dvobject\", \"list\") attr(twosides_db, \"original_db_info\") <- list(type=\"TWOSIDES\", version=\"2.0\") } # Review structure show_dvobject_metadata(twosides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 1 0 217.6 Kb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"merging-the-databases-chaining","dir":"Articles","previous_headings":"","what":"2. Merging the Databases (Chaining)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"integrate databases chain. First, merge OnSIDES DrugBank, merge TWOSIDES result. creates single “Hub Spoke” object centered DrugBank.","code":"# Step 1: Merge DrugBank + OnSIDES db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) # Step 2: Merge Result + TWOSIDES # The function is chainable and automatically detects the existing data final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) # Review final object structure # Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' show_dvobject_metadata(final_db) #> === BASIC INFO === #> Class Total_DataFrames #> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject 68 #> Top_Level_Lists Object_Size #> 1 4 4.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> First Database DrugBank 5.1 2025-01-02 #> Second Database TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugbank$drugs$general_information 2 15 8 Kb #> drugbank$drugs$drug_classification 2 9 3.8 Kb #> drugbank$drugs$synonyms 15 4 3.6 Kb #> drugbank$drugs$pharmacology 2 12 18.1 Kb #> drugbank$drugs$international_brands 9 3 2.7 Kb #> drugbank$drugs$mixtures 5 3 2 Kb #> drugbank$drugs$packagers 35 3 6.2 Kb #> drugbank$drugs$manufacturers 13 4 2.9 Kb #> drugbank$drugs$prices 16 5 4.6 Kb #> drugbank$drugs$categories 58 3 9.2 Kb #> drugbank$drugs$dosages 189 4 17.4 Kb #> drugbank$drugs$atc_codes 4 10 4.3 Kb #> drugbank$drugs$patents 35 6 8.6 Kb #> drugbank$drugs$drug_interactions 1645 4 514.7 Kb #> drugbank$drugs$sequences 1 3 1.3 Kb #> drugbank$drugs$calculated_properties 26 4 5.6 Kb #> drugbank$drugs$experimental_properties 5 4 2.4 Kb #> drugbank$drugs$external_identifiers 30 3 4.7 Kb #> drugbank$drugs$pdb_entries 19 2 2.4 Kb #> drugbank$drugs$affected_organisms 2 2 1.2 Kb #> drugbank$drugs$groups 4 2 1.3 Kb #> drugbank$drugs$external_links 5 3 2.1 Kb #> drugbank$salts 2 8 2.8 Kb #> drugbank$products 190 19 68.6 Kb #> drugbank$references$drugs$articles 13 4 6.3 Kb #> drugbank$references$drugs$links 11 4 6.1 Kb #> drugbank$references$carriers$books 1 4 1.6 Kb #> drugbank$references$carriers$articles 15 4 5.4 Kb #> drugbank$references$enzymes$books 33 4 8.2 Kb #> drugbank$references$enzymes$articles 1573 4 485.5 Kb #> drugbank$references$enzymes$links 615 4 164.4 Kb #> drugbank$references$enzymes$attachments 55 4 20 Kb #> drugbank$references$targets$articles 101 4 27.4 Kb #> drugbank$references$targets$links 14 4 7.1 Kb #> drugbank$cett$carriers$general_information 1 6 1.9 Kb #> drugbank$cett$carriers$actions 2 2 1.2 Kb #> drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb #> drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb #> drugbank$cett$enzymes$general_information 2 8 2.6 Kb #> drugbank$cett$enzymes$actions 7 2 1.5 Kb #> drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb #> drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb #> drugbank$cett$targets$general_information 4 6 2.6 Kb #> drugbank$cett$targets$actions 10 2 1.9 Kb #> drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb #> drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb #> drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb #> onsides$product_adverse_effect 52745 7 2.2 Mb #> onsides$high_confidence 2 2 1.4 Kb #> onsides$product_label 95 5 39.7 Kb #> onsides$product_to_rxnorm 160 2 5.5 Kb #> onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb #> onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb #> onsides$vocab_rxnorm_product 17 3 4.9 Kb #> integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb #> integrated_data$high_confidence_enriched 2 3 1.6 Kb #> integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb #> integrated_data$drug_drug_interactions 1706 17 300.9 Kb #> twosides$drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-leuprolide-db00007","dir":"Articles","previous_headings":"","what":"3. Single Drug Analysis: Leuprolide (DB00007)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Scientific Context: Leuprolide GnRH analog. first establish baseline side effect profile OnSIDES.","code":"target_drug_id <- \"DB00007\" # Leuprolide # 1. Get the RxNorm ID from the bridge table mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id) target_rxcui <- mapping_df$rxcui[1] print(paste0(\"DrugBank ID: \", target_drug_id, \" maps to RxNorm CUI: \", target_rxcui)) #> [1] \"DrugBank ID: DB00007 maps to RxNorm CUI: 42375\""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"extract-baseline-adverse-events-onsides","dir":"Articles","previous_headings":"3. Single Drug Analysis: Leuprolide (DB00007)","what":"3.1 Extract Baseline Adverse Events (OnSIDES)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"# 1. Find product labels linked to this ingredient product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui) %>% pull(product_id) target_label_ids <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis) %>% pull(label_id) # 2. Extract and summarize events ae_summary <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) # Fill NAs for demo purposes (if vocab is incomplete in sample) ae_summary <- ae_summary %>% mutate(meddra_name = case_when( effect_meddra_id == 10033336 ~ \"Pain\", effect_meddra_id == 10039769 ~ \"Rash\", effect_meddra_id == 10052995 ~ \"Hot flush\", effect_meddra_id == 10009226 ~ \"Constipation\", effect_meddra_id == 10006068 ~ \"Bone pain\", TRUE ~ meddra_name )) %>% rename(Adverse_Event = meddra_name) print(ae_summary) #> # A tibble: 10 × 3 #> effect_meddra_id Adverse_Event Count #> #> 1 10033336 Pain 10659 #> 2 10029197 Nervous 711 #> 3 10039769 Rash 526 #> 4 10017735 Gas 504 #> 5 10010904 Convulsion 424 #> 6 10019211 Headache 351 #> 7 10052995 Hot flush 350 #> 8 10010914 Convulsions 349 #> 9 10009226 Constipation 262 #> 10 10006068 Bone pain 247"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-calcitriol-db00136","dir":"Articles","previous_headings":"","what":"4. Single Drug Analysis: Calcitriol (DB00136)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"repeat process Calcitriol establish baseline.","code":"target_drug_id_2 <- \"DB00136\" # Get RxCUI mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id_2) target_rxcui_2 <- mapping_df_2$rxcui[1] # Get Products & Labels product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui_2) %>% pull(product_id) target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis_2) %>% pull(label_id) # Summarize Events ae_summary_2 <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids_2) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) %>% mutate(meddra_name = ifelse(is.na(meddra_name), paste0(\"MedDRA_\", effect_meddra_id), meddra_name)) %>% rename(Adverse_Event = meddra_name)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"polypharmacy-analysis-drug-drug-interactions","dir":"Articles","previous_headings":"","what":"5. Polypharmacy Analysis: Drug-Drug Interactions","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"New Insight: happens Leuprolide Calcitriol taken together? query integrated_data$drug_drug_interactions table, populated merge_drugbank_twosides. table allows us look interactions DrugBank ID, using enriched columns provided merge.","code":"# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) interaction_data <- final_db$integrated_data$drug_drug_interactions %>% filter( (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) ) %>% arrange(desc(as.numeric(PRR))) %>% select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) print(interaction_data) #> drug_name_1 drug_name_2 condition_concept_name PRR #> #> 1: Leuprolide Calcitriol Platelet count decreased 15 #> 2: Leuprolide Calcitriol Disturbance in attention 5 #> 3: Leuprolide Calcitriol Haemorrhage 5 #> mean_reporting_frequency #> #> 1: 0.0909091 #> 2: 0.0303030 #> 3: 0.0303030"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"visualization-of-interaction-risks","dir":"Articles","previous_headings":"5. Polypharmacy Analysis: Drug-Drug Interactions","what":"5.1 Visualization of Interaction Risks","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"can visualize specific adverse events associated combination, ranked Proportional Reporting Ratio (PRR) (measure signal strength).","code":"if(nrow(interaction_data) > 0) { # Prepare data for canvasXpress cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) rownames(cx_int_data) <- interaction_data$condition_concept_name canvasXpress( data = t(cx_int_data), graphType = \"Bar\", title = \"Polypharmacy Risks: Leuprolide + Calcitriol\", subtitle = \"Data from TWOSIDES\", xAxisTitle = \"Signal Strength (PRR)\", yAxisTitle = \"Adverse Event\", showLegend = FALSE ) } else { print(\"No interaction data found for this specific pair in the sample dataset.\") }"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"comparative-overview","dir":"Articles","previous_headings":"","what":"6. Comparative Overview","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, can view single-drug profiles alongside interaction profile see new risks emerge.","code":"# 1. Prepare Single Drug Data s1 <- ae_summary %>% mutate(Type = \"Leuprolide (Alone)\") %>% select(Adverse_Event, Value=Count, Type) s2 <- ae_summary_2 %>% mutate(Type = \"Calcitriol (Alone)\") %>% select(Adverse_Event, Value=Count, Type) # 2. Prepare Interaction Data (Show Top 5) # Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, # so we visualize them to show relative importance within their own context. s3 <- interaction_data %>% head(5) %>% mutate(Type = \"Interaction (PRR)\", Value = as.numeric(PRR)) %>% select(Adverse_Event = condition_concept_name, Value, Type) # 3. Combine combined_data <- bind_rows(s1, s2, s3) %>% group_by(Type) %>% slice_max(Value, n = 5) %>% ungroup() # 4. Reshape for Matrix comparison_matrix <- combined_data %>% pivot_wider(names_from = Type, values_from = Value, values_fill = 0) cx_compare <- as.data.frame(comparison_matrix[, -1]) rownames(cx_compare) <- comparison_matrix$Adverse_Event # 5. Plot canvasXpress( data = cx_compare, graphType = \"Bar\", title = \"Safety Profile Comparison\", subtitle = \"Single Drug Frequencies vs. Interaction PRR\", xAxisTitle = \"Value\", yAxisTitle = \"Adverse Event\", legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"conclusion","dir":"Articles","previous_headings":"","what":"7. Conclusion","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"analysis highlights power dbparser integration ecosystem: DrugBank provided identity mechanism Leuprolide Calcitriol. OnSIDES quantified individual side effects (e.g., Pain, Hot Flushes). TWOSIDES revealed specific risks drugs combined (e.g., Anaemia). chaining merge_drugbank_onsides merge_drugbank_twosides, researchers can perform comprehensive safety assessments across mechanistic, real-world, polypharmacy domains just lines R code.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Mohammed Ali. Author, maintainer. Ali Ezzat. Author. Hao Zhu. Reviewer. Emma Mendelsohn. Reviewer.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. R package version 2.2.0.","code":"@Manual{, title = {DrugBank Database XML Parser}, author = {Mohammed Ali and Ali Ezzat}, organization = {Interstellar for Consultinc inc.}, note = {R package version 2.2.0}, url = {https://CRAN.R-project.org/package=dbparser}, }"},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"interest fostering open welcoming environment, contributors maintainers pledge making participation project community harassment-free experience everyone, regardless age, body size, disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, religion, sexual identity orientation.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes creating positive environment include: Using welcoming inclusive language respectful differing viewpoints experiences Gracefully accepting constructive criticism Focusing best community Showing empathy towards community members Examples unacceptable behavior participants include: use sexualized language imagery unwelcome sexual attention advances Trolling, insulting/derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical electronic address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-responsibilities","dir":"","previous_headings":"","what":"Our Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Project maintainers responsible clarifying standards acceptable behavior expected take appropriate fair corrective action response instances unacceptable behavior. Project maintainers right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, ban temporarily permanently contributor behaviors deem inappropriate, threatening, offensive, harmful.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within project spaces public spaces individual representing project community. Examples representing project community include using official project e-mail address, posting via official social media account, acting appointed representative online offline event. Representation project may defined clarified project maintainers.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported contacting project team mohammed.ali@edu.dsti.institute. complaints reviewed investigated result response deemed necessary appropriate circumstances. project team obligated maintain confidentiality regard reporter incident. details specific enforcement policies may posted separately. Project maintainers follow enforce Code Conduct good faith may face temporary permanent repercussions determined members project’s leadership.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 1.4, available https://www.contributor-covenant.org/version/1/4/code--conduct.html answers common questions code conduct, see https://www.contributor-covenant.org/faq","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contributing to dbparser","title":"Contributing to dbparser","text":"First , thanks considering contributing dbparser! 👍 ’s people like make rewarding us - project maintainers - work dbparser. 😊 dbparser open source project, maintained people care. directly funded .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of conduct","title":"Contributing to dbparser","text":"Please note project released Contributor Code Conduct. participating project agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"how-you-can-contribute","dir":"","previous_headings":"","what":"How you can contribute","title":"Contributing to dbparser","text":"several ways can contribute project. want know contribute open source projects like one, see Open Source Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"share-the-love-heart","dir":"","previous_headings":"How you can contribute","what":"Share the love ❤️","title":"Contributing to dbparser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"ask-a-question-interrobang","dir":"","previous_headings":"How you can contribute","what":"Ask a question ⁉️","title":"Contributing to dbparser","text":"Using our_package got stuck? Browse documentation see can find solution. Still stuck? Post question issue GitHub. offer user support, ’ll try best address , questions often lead better documentation discovery bugs. Want ask question private? Contact package maintainer email.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"propose-an-idea-bulb","dir":"","previous_headings":"How you can contribute","what":"Propose an idea 💡","title":"Contributing to dbparser","text":"idea new our_package feature? Take look documentation issue list see isn’t included suggested yet. , suggest idea issue GitHub. can’t promise implement idea, helps : Explain detail work. Keep scope narrow possible. See want contribute code idea well.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"report-a-bug-bug","dir":"","previous_headings":"How you can contribute","what":"Report a bug 🐛","title":"Contributing to dbparser","text":"Using our_package discovered bug? ’s annoying! Don’t let others experience report issue GitHub can fix . good bug report makes easier us , please include: operating system name version (e.g. Mac OS 10.13.6). details local setup might helpful troubleshooting. Detailed steps reproduce bug.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"improve-the-documentation-open_book","dir":"","previous_headings":"How you can contribute","what":"Improve the documentation 📖","title":"Contributing to dbparser","text":"Noticed typo website? Think function use better example? Good documentation makes difference, help improve welcome!","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"the-website","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"The website","title":"Contributing to dbparser","text":"website generated pkgdown. means don’t write html: content pulled together documentation code, vignettes, Markdown files, package DESCRIPTION _pkgdown.yml settings. know way around pkgdown, can propose file change improve documentation. , report issue can point right direction.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"function-documentation","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"Function documentation","title":"Contributing to dbparser","text":"Functions described comments near code translated documentation using roxygen2. want improve function description: Go R/ directory code repository. Look file name function. Propose file change update function documentation roxygen comments (starting #').","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"contribute-code-pencil","dir":"","previous_headings":"How you can contribute","what":"Contribute code 📝","title":"Contributing to dbparser","text":"Care fix bugs implement new functionality our_package? Awesome! 👏 look issue list leave comment things want work . See also development guidelines .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"development-guidelines","dir":"","previous_headings":"","what":"Development guidelines","title":"Contributing to dbparser","text":"try follow GitHub flow development. Fork repo clone computer. learn process, see guide. forked cloned project since worked , pull changes original repo clone using git pull upstream master. Open RStudio project file (.Rproj). Write code. Test code (bonus points adding unit tests). Document code (see function documentation ). Check code devtools::check() aim 0 errors warnings. Commit push changes. Submit pull request.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Drugs Databases Parser","text":"Drugs databases vary much formats structures making related data analysis easy job requires lot efforts work two databases together DrugBank, OnSIDES, TWOSIDES. Hence, dbparser package aims parse different public drugs databases single unified format R object called dvobject (stands drugverse object). recent updates, dbparser evolved integration engine, allowing merge mechanistic data (DrugBank) real-world phenotypic data (OnSIDES) drug-drug interaction risks (TWOSIDES). help : working single data object multiple databases different formats, using R analysis capabilities easily drugs data, ease transferring data researchers performing required data analysis dvobject storing results object easy manner.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"dvobject-structure","dir":"","previous_headings":"Overview","what":"dvobject Structure","title":"Drugs Databases Parser","text":"dvobject introduces unified compressed format drugs data. R list object. single database (e.g., DrugBank): contains one following sub-lists: drugs: list data.frames contain drugs information (.e. synonyms, classifications, …) mandatory list salts: data.frame contains drugs salts information products: data.frame commercially available drugs products world references: data.frame articles, links textbooks drugs CETT data cett: list data.frames contain targets, enzymes, carriers transporters information merged database (Integrated Pharmacovigilance): databases merged using merge_drugbank_onsides merge_drugbank_twosides, dvobject becomes nested structure containing: drugbank: mechanistic hub. onsides: side-effect data (FDA labels). twosides: drug-drug interaction data. integrated_data: Enriched tables bridge databases (e.g., linking DrugBank IDs OnSIDES adverse events). metadata: Detailed provenance contained datasets.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"drug-databases","dir":"","previous_headings":"","what":"Drug Databases","title":"Drugs Databases Parser","text":"Parsers available following databases (progress list)","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_1-drugbank","dir":"","previous_headings":"Drug Databases","what":"1. DrugBank","title":"Drugs Databases Parser","text":"DrugBank database comprehensive, freely accessible, online database containing information drugs drug targets. bioinformatics cheminformatics resource, DrugBank combines detailed drug (.e. chemical, pharmacological pharmaceutical) data comprehensive drug target (.e. sequence, structure, pathway) information. information DrugBank can found . raw form, DrugBank database single XML file. Users must create account DrugBank request permission download database. Note may take couple days. dbparser package parses DrugBank XML database R tibbles can explored analyzed user, check tutorial details. waiting access DrugBank database, intend deep dive data, may wish use dbdataset package, contains DrugBank database already parsed dvobject. Note large package exceeds limit set CRAN. available GitHub. dbparser tested DrugBank versions 5.1.0 5.1.12 successfully. find errors versions version please submit issue .","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_2-onsides-the-phenotype","dir":"","previous_headings":"Drug Databases","what":"2. OnSIDES (The Phenotype)","title":"Drugs Databases Parser","text":"OnSIDES provides adverse drug events extracted thousands FDA drug labels using machine learning. * Parser: parseOnSIDES() * Input: Directory containing OnSIDES CSV files.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_3-twosides-polypharmacy","dir":"","previous_headings":"Drug Databases","what":"3. TWOSIDES (Polypharmacy)","title":"Drugs Databases Parser","text":"TWOSIDES provides data drug-drug interactions adverse events arise two drugs taken together. * Parser: parseTWOSIDES() * Input: TWOSIDES.csv.gz file.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"quick-start-integration-pipeline","dir":"","previous_headings":"","what":"Quick Start: Integration Pipeline","title":"Drugs Databases Parser","text":"power dbparser lies ability chain parsers mergers together. can build complete pharmacovigilance dataset: detailed case study, please refer Integrated Pharmacovigilance Vignette.","code":"library(dbparser) library(dplyr) # 1. Parse the raw databases drugbank_db <- parseDrugBank(\"data/drugbank.xml\") onsides_db <- parseOnSIDES(\"data/onsides/\") twosides_db <- parseTWOSIDES(\"data/TWOSIDES.csv.gz\") # 2. Build the Integrated Knowledge Graph # DrugBank serves as the hub. We chain the merges. final_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db) # 3. Analyze Results # Example: Accessing the enriched drug-drug interaction table head(final_db$integrated_data$drug_drug_interactions)"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Drugs Databases Parser","text":"can install released version dbparser CRAN : can install latest updates directly repo","code":"install.packages(\"dbparser\") library(devtools) devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Drugs Databases Parser","text":"Please note ‘dbparser’ project released Contributor Code Conduct. contributing project, agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"contributing-guide","dir":"","previous_headings":"","what":"Contributing Guide","title":"Drugs Databases Parser","text":"👍🎉 First , thanks taking time contribute! 🎉👍 Please review Contributing Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"share-the-love-heart","dir":"","previous_headings":"","what":"Share the love ❤️","title":"Drugs Databases Parser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing ","code":"citation(\"dbparser\") #> To cite dbparser in publications use: #> #> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. #> R package version 2.2.0. #> #> A BibTeX entry for LaTeX users is #> #> @Manual{, #> title = {DrugBank Database XML Parser}, #> author = {Mohammed Ali and Ali Ezzat}, #> organization = {Interstellar for Consultinc inc.}, #> note = {R package version 2.2.0}, #> url = {https://CRAN.R-project.org/package=dbparser}, #> }"},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":null,"dir":"Reference","previous_headings":"","what":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"add_database_info Assign passed databases db metadata passed dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"","code":"add_database_info( dvobject, db_type = \"DrugBank\", db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject dvobject assign metadata db_type database type (defualt=\"DrugBank\") db_version database version string db_exported_date database official export date","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"Return list articles used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"","code":"drugs_articles() carriers_articles() enzymes_articles() targets_articles() transporters_articles()"},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). pubmed-id PubMed identifier article. citation Article citation standard format. parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"Return list attachment used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"","code":"drugs_attachments() carriers_attachments() enzymes_attachments() targets_attachments() transporters_attachments()"},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). title title attachment. url url download attachment . parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"Return list text books used references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"","code":"drugs_textbooks() carriers_textbooks() enzymes_textbooks() targets_textbooks() transporters_textbooks()"},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). isbn ISBN identifying textbook. citation Textbook citation standard format. parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Build Metadata Data Frame — build_metadata","title":"Build Metadata Data Frame — build_metadata","text":"Build Metadata Data Frame","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Build Metadata Data Frame — build_metadata","text":"","code":"build_metadata(attrs, has_second_db, second_db_name)"},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Build Metadata Data Frame — build_metadata","text":"attrs Attributes list has_second_db Logical indicating second database exists second_db_name Name second database attribute","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Build Metadata Data Frame — build_metadata","text":"Data.frame database metadata","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"Collection related actions","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"","code":"carriers_actions() enzymes_actions() targets_actions() transporters_actions()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"tibble 2 variables: action describe related action parent_id carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"Protein targets drug action, enzymes inhibited/induced involved metabolism, carrier transporter proteins involved movement drug across biological membranes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"","code":"carriers() enzymes() targets() transporters()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"tibble 6 variables (8 enzymes): id Universal Protein Resource (UniProt) Identifier record name related name organism Organism protein comes . known_action Whether pharmacological action drug due target interaction. inhibition-strength Whether strength enzyme inhibition strong, moderate, unknown. applies enzymes induction-strength Whether strength enzyme induction strong unknown. applies enzymes position related position parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"Extract descriptions identified polypeptide external identifiers targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"","code":"carriers_polypep_ex_ident() enzymes_polypep_ex_ident() targets_polypep_ex_ident() transporters_polypep_ex_ident()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"tibble 3 variables: resource Name source database. identifier Identifier drug given resource. parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"Extract descriptions identified polypeptide go classifier targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"","code":"carriers_polypeptides_go() enzymes_polypeptides_go() targets_polypeptides_go() transporters_polypeptides_go()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"tibble 3 variables: category description parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"returns carriers, enzymes,targets transporters node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"","code":"cett_nodes_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"list CETT valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"Extract descriptions identified polypeptide targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"","code":"carriers_polypeptides() enzymes_polypeptides() targets_polypeptides() transporters_polypeptides()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"tibble 20 variables: id Universal Protein Resource (UniProt) identifier source Specifies whether identified polypeptide ID associated following UniProt knowledge bases: Swiss-Prot, manually annotated reviewed, TrEMBL, automatically annotated reviewed. name general_function General summary physiological function polypeptide specific_function specific description polypeptide’s physiological function within cell. gene_name short name commonly associated associated gene. Eg. PTGS1. locus specific chromosomal location position gene’s sequence chromosome. cellular_location cellular location polypeptide. transmembrane_regions Areas polypeptide sequence span biological membrane. signal_regions Location signal peptides within polypeptide sequence. theoretical_pi Theoretical isoelectric point. molecular_weight molecular weight polypeptide. chromosome_location chromosomal location polypeptide gene organism organism polypeptide functions. organism_ncbi_taxonomy_id amino_acid_sequence amino acid sequence polypeptide amino_acid_format gene_sequence sequence associated gene. gene_format parent_key carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"Extract descriptions identified polypeptide PFAMS targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"","code":"carriers_polypeptides_pfams() enzymes_polypeptides_pfams() targets_polypeptides_pfams() transporters_polypeptides_pfams()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"tibble 3 variables: name sequence associated gene. identifier parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"Extract descriptions identified polypeptide synonyms targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"","code":"carriers_polypeptides_syn() enzymes_polypeptides_syn() targets_polypeptides_syn() transporters_polypeptides_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"tibble 2 variables: synonym parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":null,"dir":"Reference","previous_headings":"","what":"Count Top Level Lists — count_top_level_lists","title":"Count Top Level Lists — count_top_level_lists","text":"Count Top Level Lists","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Count Top Level Lists — count_top_level_lists","text":"","code":"count_top_level_lists(obj)"},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Count Top Level Lists — count_top_level_lists","text":"obj Object analyze","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Count Top Level Lists — count_top_level_lists","text":"Integer count top-level lists (excluding data.frames)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":null,"dir":"Reference","previous_headings":"","what":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"main purpose `dbparser` package parse [DrugBank](https://go.drugbank.com/) database downloadable XML format [link](https://go.drugbank.com/releases/latest).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parsed data can explored analyzed. achieve purpose, `dbparser“ package provides three main categories functions: - xml db reader, - DrugBank elements parsers, information kindly check reference/index (https://docs.ropensci.org/dbparser/reference/index.html)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"xml-db-reader-functions","dir":"Reference","previous_headings":"","what":"xml db reader functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Reads DrugBank xml database build drug elements full tree memory","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"parsers-functions","dir":"Reference","previous_headings":"","what":"parsers functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parser function responsible parsing certain drug element returning tibble. Check tutorial (https://docs.ropensci.org/dbparser/articles/dbparser.html)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Maintainer: Mohammed Ali moh_fcis@yahoo.com Authors: Ali Ezzat ali_ezzat85@yahoo.com contributors: Hao Zhu haozhu233@gmail.com [reviewer] Emma Mendelsohn [reviewer]","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Affected Organism parser — drug_affected_organisms","title":"Drug Affected Organism parser — drug_affected_organisms","text":"Organisms drug may display activity; activity may depend local susceptibility patterns resistance.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Affected Organism parser — drug_affected_organisms","text":"","code":"drug_affected_organisms()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Affected Organism parser — drug_affected_organisms","text":"tibble 2 variables: affected-organism affected-organism name drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ahfs-codes parser — drug_ahfs_codes","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"American Hospital Formulary Service (AHFS) identifier drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"","code":"drug_ahfs_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"tibble following variables: ahfs-code drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ATC Codes element parser — drug_atc_codes","title":"Drug ATC Codes element parser — drug_atc_codes","text":"Anatomical Therapeutic Classification (ATC) code drug assigned World Health Organization Anatomical Chemical Classification System.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ATC Codes element parser — drug_atc_codes","text":"","code":"drug_atc_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ATC Codes element parser — drug_atc_codes","text":"tibble 10 variables","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug ATC Codes element parser — drug_atc_codes","text":"`atc-code“ row one level. atc-code level> code code assigned World Health Organization Anatomical Therapeutic Chemical Classification system.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Calculated Properties parser — drug_calc_prop","title":"Drug Calculated Properties parser — drug_calc_prop","text":"Drug properties predicted ChemAxon ALOGPS based imputed chemical structure. Associated links redirect descriptions specific term.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Calculated Properties parser — drug_calc_prop","text":"","code":"drug_calc_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Calculated Properties parser — drug_calc_prop","text":"tibble 4 variables: kind Name property. value Predicted physicochemical properties; obtained use prediction software ALGOPS ChemAxon. source Name software used calculate property, either ChemAxon ALOGPS. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Categories parser — drug_categories","title":"Drug Categories parser — drug_categories","text":"General categorizations drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Categories parser — drug_categories","text":"","code":"drug_categories()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Categories parser — drug_categories","text":"tibble 2 variables: category category name mesh-id Medical Subjects Headings (MeSH) identifier category. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Classification parser — drug_classification","title":"Drug Classification parser — drug_classification","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Classification parser — drug_classification","text":"","code":"drug_classification()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Classification parser — drug_classification","text":"tibble 9 variables: description direct-parent kingdom superclass class subclass alternative-parent One alternative parents substituent One substituents drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Dosages parser — drug_dosages","title":"Drug Dosages parser — drug_dosages","text":"list commercially available dosages drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Dosages parser — drug_dosages","text":"","code":"drug_dosages()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Dosages parser — drug_dosages","text":"tibble following variables: form pharmaceutical formulation drug introduced body route path drug product taken body. strength amount active drug ingredient provided dosage drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Experimental Properties parser — drug_exp_prop","title":"Drug Experimental Properties parser — drug_exp_prop","text":"Drug properties experimentally proven","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Experimental Properties parser — drug_exp_prop","text":"","code":"drug_exp_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Experimental Properties parser — drug_exp_prop","text":"tibble following variables: kind Name property. value Drug properties experimentally proven. source Reference source experimental data. drugbank_id drugbank id following experimental properties provided: Water Solubility experimentally determined aqueous solubility molecule. Molecular Formula Protein formula Biotech drugs Molecular Weight Protein weight Biotech drugs. Melting Point experimentally determined temperature drug molecule changes solid liquid atmospheric temperature. Boiling Point experimentally determined temperature drug molecule changes liquid gas atmospheric temperature. Hydrophobicity ability molecule repel water rather absorb dissolve water. Isoelectric Point pH value net electric charge molecule zero. caco2 Permeability continuous line heterogenous human epithelial colorectal adenocarcinoma cells, CAC02 cells employed model human intestinal absorption various drugs compounds. CAC02 cell permeability ultimately assay measure drug absorption. pKa experimentally determined pka value molecule logP experimentally determined partition coefficient (LogP) based ratio solubility molecule 1-octanol compared water. logS intrinsic solubility given compound concentration equilibrium solid phase dissolves solution, given natural logarithm (LogS) concentration. Radioactivity property spontaneously emit particles (alpha, beta, neutron) radiation (gamma, K capture), time, decay certain nuclides.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Links parser — drug_external_links","title":"Drug External Links parser — drug_external_links","text":"Links websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Links parser — drug_external_links","text":"","code":"drug_external_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Links parser — drug_external_links","text":"tibble following variables: resource Name source website. identifier Identifier drug given resource drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Identifiers parser — drug_ex_identity","title":"Drug External Identifiers parser — drug_ex_identity","text":"Identifiers used websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Identifiers parser — drug_ex_identity","text":"","code":"drug_ex_identity()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Identifiers parser — drug_ex_identity","text":"tibble following variables: resource Name source database. identifier Identifier drug given resource. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_food_interactions","title":"Drug Groups parser — drug_food_interactions","text":"Food may interact drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_food_interactions","text":"","code":"drug_food_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_food_interactions","text":"tibble following variables: food-interaction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs General Information parser — drug_general_information","title":"Drugs General Information parser — drug_general_information","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs General Information parser — drug_general_information","text":"","code":"drug_general_information()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs General Information parser — drug_general_information","text":"tibble 15 variables: primary_key DrugBank id other_keys identifiers may associated drug type Either small molecule, biotech. Biotech used drug derived living systems organisms, usually composed high molecular weight mixtures protein, small molecule describes low molecular weight organic compound. name created Date drug first added DrugBank. updated Denotes drug last updated DrugBank. description Descriptions drug chemical properties, history regulatory status. cas_number Chemical Abstracts Service (CAS) registry number assigned drug. unii Unique Ingredient Identifier (UNII) drug. average_mass weighted average isotopic masses drug state One solid, liquid, gas monoisotopic_mass mass abundant isotope drug synthesis_reference Citation synthesis drug molecule. fda_label Contains URL accessing uploaded United States Food Drug Administration (FDA) Monograph drug. msds Contains URL accessing Material Safety Data Sheet (MSDS) drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_groups","title":"Drug Groups parser — drug_groups","text":"Groups drug belongs . May include : approved, vet_approved, nutraceutical, illicit, withdrawn, investigational, experimental.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_groups","text":"","code":"drug_groups()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_groups","text":"tibble 2 variables: group drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Interactions parser — drug_interactions","title":"Drug Interactions parser — drug_interactions","text":"Drug-drug interactions detailing drugs , administered concomitantly drug interest, affect activity result adverse effects. interactions may synergistic antagonistic depending physiological effects mechanism action drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Interactions parser — drug_interactions","text":"","code":"drug_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Interactions parser — drug_interactions","text":"tibble following variables: drugbank-id DrugBank ID interacting drug. name Name interacting drug. description Textual description physiological consequences drug interaction drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug International Brands parser — drug_intern_brand","title":"Drug International Brands parser — drug_intern_brand","text":"proprietary names used manufacturers commercially available forms drug, focusing brand names products available countries Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug International Brands parser — drug_intern_brand","text":"","code":"drug_intern_brand()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug International Brands parser — drug_intern_brand","text":"tibble 4 variables: brand proprietary, well-known name given drug manufacturer. company company manufacturer uses name. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Manufacturers parser — drug_manufacturers","title":"Drug Manufacturers parser — drug_manufacturers","text":"list companies manufacturing commercially available forms drug available Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Manufacturers parser — drug_manufacturers","text":"","code":"drug_manufacturers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Manufacturers parser — drug_manufacturers","text":"tibble following variables: generic list companies manufacturing generic form drug. url link companies manufacturing drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Mixtures parser — drug_mixtures","title":"Drug Mixtures parser — drug_mixtures","text":"commercially available products drug available combination drug molecules","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Mixtures parser — drug_mixtures","text":"","code":"drug_mixtures()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Mixtures parser — drug_mixtures","text":"tibble 4 variables: name proprietary name provided manufacturer combination product. ingredients list ingredients, separated addition symbols supplemental-ingredients List additional active ingredients clinically relevant main indication product, separated addition symbols. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns drug node valid options. — drug_node_options","title":"returns drug node valid options. — drug_node_options","text":"returns drug node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns drug node valid options. — drug_node_options","text":"","code":"drug_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns drug node valid options. — drug_node_options","text":"list drug valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Packagers parser — drug_packagers","title":"Drug Packagers parser — drug_packagers","text":"list companies packaging drug re-distribution.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Packagers parser — drug_packagers","text":"","code":"drug_packagers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Packagers parser — drug_packagers","text":"tibble 2 variables: name url link companies packaging drug re-distribution. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"Drug Patents parser property right issued United States Patent Trademark Office (USPTO) inventor limited time, exchange public disclosure invention patent granted. Drugs may issued multiple patents.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"","code":"drug_patents()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"tibble following variables: number patent number(s) associated drug. country country issued patent rights. approved date patent request filed. expires date patent rights expire. pediatric-extension Indicates whether pediatric extension approved patent. Granted pediatric extensions provide additional 6 months market protection. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway parser — drug_pathway","title":"Drug Pathway parser — drug_pathway","text":"Metabolic, disease, biological pathways drug involved , identified Small Molecule Protein Database (SMPDB).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway parser — drug_pathway","text":"","code":"drug_pathway()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway parser — drug_pathway","text":"tibble following variables: smpdb-id Small Molecule Pathway Database identifier pathway. name Pathway name category Pathway category drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Drugs parser — drug_pathway_drugs","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"Drugs involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"","code":"drug_pathway_drugs()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"tibble pathway drugs properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Enzymes parser — drug_pathway_enzyme","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"Enzymes involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"","code":"drug_pathway_enzyme()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"tibble pathway properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug pdb-entries parser — drug_pdb_entries","title":"Drug pdb-entries parser — drug_pdb_entries","text":"Protein Data Bank (PDB) identifiers drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug pdb-entries parser — drug_pdb_entries","text":"","code":"drug_pdb_entries()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug pdb-entries parser — drug_pdb_entries","text":"tibble following variables: pdb-entry drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pharmacology parser — drug_pharmacology","title":"Drug Pharmacology parser — drug_pharmacology","text":"Describes use, mechanism action, pharmacokinetics, pharmacodynamics, physiological biochemical effects body.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pharmacology parser — drug_pharmacology","text":"","code":"drug_pharmacology()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pharmacology parser — drug_pharmacology","text":"tibble following variables: indication approved conditions, diseases, states drug can safely effectively used. indication considered FDA-approved following designations: NDA, ANDA, BLA, OTC. May also include indications countries, Canada (Health Canada) Europe (European Medicines Agency). pharmacodynamics description drug modifies affects organism used . May include effects body desired (enzyme protein targets example) undesired (also known “side effects”). contrast pharmacokinetics, describes body modifies drug used. mechanism_of_action component pharmacodynamics describes biochemical interaction drug produces intended effect. May include exact molecular protein enzyme targets / description physiological effects produced. toxicity adverse reaction, side effect, may may occur use drug. May attributed number effects including: enhanced therapeutic effect, rare anaphylactic reactions, interactions medications, unanticipated binding molecule different sites within body. metabolism description chemical degradation drug molecule within body; commonly enzymes Cytochrome P450 (CYP) system liver. absorption description movement drug site administration bloodstream target tissue. Common pharmacokinetic metrics used evaluate absorption include Area Curve (AUC), bioavailability (F), maximum concentration (Cmax), time maximum concentration (Tmax). half-life period time takes amount drug body reduced one half. Provides description quickly drug eliminated much available bloodstream. protein-binding description drug’s affinity plama proteins proportion drug bound circulation within body. route_of_elimination description pathway used excrete drug body. Common pharmacokinetic parameters used evaluate excretion include elimination half life, renal clearance, tracking radiolabelled compounds renal GI system. volume_of_distribution Vd drug represents degree distributed body tissue compared plasma. clearance pharmacokinetic measurement rate removal drug plasma, expressed mL/min; reflects rate elimination drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Prices Parsers — drug_prices","title":"Drug Prices Parsers — drug_prices","text":"Unit drug prices","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Prices Parsers — drug_prices","text":"","code":"drug_prices()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Prices Parsers — drug_prices","text":"tibble 5 variables: description cost Drug price per unit currency Currency price, example: US. unit parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Products parser — drug_products","title":"Drug Products parser — drug_products","text":"list commercially available products Canada United States contain drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Products parser — drug_products","text":"","code":"drug_products()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Products parser — drug_products","text":"tibble 32 variables: name proprietary name(s) provided manufacturer commercially available products containing drug. labeller corporation responsible labelling product. ndc-id National Drug Code (NDC) identifier drug ndc-product-code National Drug Code (NDC) product code FDA National Drug Code directory. dpd-id Drug Product Database (DPD) identification number (.k.. DIN) Canadian Drug Product Database. present drugs marketed Canada ema-product-code EMA product code European Medicines Agency Database. present products authorized central procedure marketing European Union. ema-ma-number EMA marketing authorization number European Medicines Agency Database. present products authorized central procedure marketing European Union. started-marketing-starting date market approval. ended-marketing-ending date market approval. dosage-form pharmaceutical formulation drug introduced body. strength amount active drug ingredient provided dosage route path drug product taken body fda-application-number New Drug Application [NDA] number assigned drug FDA. --counter list Counter (OTC) forms drug. generic Whether product generic drug. approved Indicates whether drug approved regulating government. country country commercially available drug approved. source Source product information. example, value DPD indicates information retrieved Canadian Drug Product Database. standing One good, discordant, deprecated. Distinguishes products date ingredient information (good) products conflicting information (discordant) products removed active label (deprecated). standing-updated-date standing last updated standing-reason Explains non-good standing product. One : ingredient_change, code_duplication, invalid, removed. jurisdiction-marketing-category marketing category product jurisdiction branded Whether product named brand prescription Whether product available prescription unapproved Whether product approved jurisdiction vaccine Whether product vaccine allergenic Whether product used allergenic testing cosmetic Whether product cosmetic, sunscreen kit Whether product kit composed multiple distinct parts solo Whether product single active ingredient available Whether product can sold jurisdiction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Parsers — drug_reactions","title":"Drug Reactions Parsers — drug_reactions","text":"Extract sequential representation metabolic reactions drug molecule involved . Depending available information, may include metabolizing enzymes, reaction type, substrates, products, pharmacological activity metabolites, structural representation biochemical reactions.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Parsers — drug_reactions","text":"","code":"drug_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Parsers — drug_reactions","text":"tibble 5 variables: sequence Reactions displayed within numerical sequence left_drugbank_name substrate reaction. Maybe drug metabolite. rightt_drugbank_name product reaction. Maybe drug metabolite. left_drugbank_id right_drugbank_id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"Enzymes involved metabolizing drug","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"","code":"drug_reactions_enzymes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"tibble 3 variables: name uniprot-id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Salts parser — drug_salts","title":"Drug Salts parser — drug_salts","text":"Available salt forms drug. Ions hydrochloride, sodium, sulfate often added drug molecule increase solubility, dissolution, absorption.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Salts parser — drug_salts","text":"","code":"drug_salts()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Salts parser — drug_salts","text":"tibble 1 variables: drugbank-id DrugBank identifiers available salt form(s). name Name available salt form(s) unii Unique Ingredient Identifier (UNII) available salt form(s). cas-number Chemical Abstracts Service (CAS) registry number assigned salt form(s) drug. inchikey IUPAC International Chemical Identifier (InChi) key identifier available salt form(s). average-mass Average molecular mass: weighted average isotopic masses salt. monoisotopic-mass mass abundant isotope salt smiles simplified molecular-input line-entry system (SMILES) line notation used describing structure chemical species using short ASCII strings; calculated ChemAxon. inchi prediction IUPAC International Chemical Identifier (InChI); imported ChemAxon. formula Indicates simple numbers type atom within molecule; calculated ChemAxon. drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Sequences parser — drug_sequences","title":"Drug Sequences parser — drug_sequences","text":"amino acid sequence; provided drug peptide.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Sequences parser — drug_sequences","text":"","code":"drug_sequences()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Sequences parser — drug_sequences","text":"tibble following variables: sequence textual representation sequence format Currently, FASTA format used drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug Sequences parser — drug_sequences","text":"Describes peptide sequences biotech drugs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"adverse drug reactions may occur result listed single nucleotide polymorphisms (SNPs)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"","code":"drug_snp_adverse_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. adverse-reaction description pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Effects parser — drug_snp_effects","title":"Drug SNP Effects parser — drug_snp_effects","text":"list single nucleotide polymorphisms (SNPs) relevant drug activity metabolism, effects may pharmacological activity. SNP effects patient may require close monitoring, increase ","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Effects parser — drug_snp_effects","text":"","code":"drug_snp_effects()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Effects parser — drug_snp_effects","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. defining-change description written description SNP effects. pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Synonyms parser — drug_syn","title":"Drug Synonyms parser — drug_syn","text":"names identifiers associated drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Synonyms parser — drug_syn","text":"","code":"drug_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Synonyms parser — drug_syn","text":"tibble 3 variables: language Names drug languages English. coder Organization source providing synonym. example, INN indicates synonym International Nonproprietary Name, IUPAC indicates synonym nomenclature designated International Union Pure Applied Chemistry. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":null,"dir":"Reference","previous_headings":"","what":"Find All Data Frames Recursively — find_dataframes_recursive","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Find Data Frames Recursively","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"","code":"find_dataframes_recursive(x, prefix = \"\")"},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"x Object search prefix Current path prefix","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Data.frame paths, dimensions, sizes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":null,"dir":"Reference","previous_headings":"","what":"Find Second Database in Attributes — find_second_database","title":"Find Second Database in Attributes — find_second_database","text":"Find Second Database Attributes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find Second Database in Attributes — find_second_database","text":"","code":"find_second_database(attrs)"},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find Second Database in Attributes — find_second_database","text":"attrs Attributes list","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find Second Database in Attributes — find_second_database","text":"List has_second_db (logical) second_db_name (character)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"init_dvobject initialize dvobject — init_dvobject","title":"init_dvobject initialize dvobject — init_dvobject","text":"init_dvobject initialize dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"init_dvobject initialize dvobject — init_dvobject","text":"","code":"init_dvobject()"},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"init_dvobject initialize dvobject — init_dvobject","text":"dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"Return list websites used references Drugs/ Carriers/ Enzymes/ Targets/ Transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"","code":"drugs_links() carriers_links() enzymes_links() targets_links() transporters_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"tibble 4 variables: ref-id Name source website title Identifier drug given resource url url website parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"Creates integrated dvobject object linking DrugBank dvobject OnSIDES dvobject using RxNorm CUIs bridge.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"merge_drugbank_onsides(db_object, onsides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject (containing `$drugbank`). onsides_db dvobject produced `dbparser::parseOnSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"new dvobject containing integrated data.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"function performs following key steps: 1. Creates mapping table DrugBank IDs RxNorm CUIs DrugBank object. 2. Enriches relevant OnSIDES tables (`vocab_rxnorm_ingredient` optionally `high_confidence`) adding `drugbank_id` column. 3. Assembles new list object containing original tables plus enriched ones ID mapping table . resulting object allows powerful queries span mechanistic data DrugBank clinical side-effect data OnSIDES. Supports piping chaining merge functions.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"if (FALSE) { # \\dontrun{ # First, parse the individual databases drugbank <- parseDrugBank(\"path/to/drugbank.xml\") onsides <- parseOnSIDES(\"path/to/onsides_csvs/\") # Now, merge them into a single, powerful object merged_db <- merge_drugbank_onsides(drugbank, onsides) # --- Example Analysis: Find the protein targets of all drugs known to --- # --- cause the side effect \"Hepatitis\" with high confidence. --- # 1. Find the MedDRA ID for \"Hepatitis\" hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% filter(meddra_name == \"Hepatitis\") %>% pull(meddra_id) # 2. Find all drug ingredients linked to this effect in the high_confidence table drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% filter(effect_meddra_id == hepatitis_id) %>% pull(drugbank_id) %>% na.omit() %>% unique() # 3. Look up the targets for these DrugBank IDs targets_of_interest <- merged_db$targets %>% filter(parent_key %in% drug_ids_causing_hepatitis) %>% select(drug_id = parent_key, target_name = name, gene_name) head(targets_of_interest) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"Integrates drug-drug interaction data TWOSIDES rich mechanistic information DrugBank. function chainable can accept raw DrugBank object already-merged dvobject.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"","code":"merge_drugbank_twosides(db_object, twosides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject. twosides_db dvobject `parseTWOSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"new, nested dvobject TWOSIDES data added.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":null,"dir":"Reference","previous_headings":"","what":"parseDrugBank — parseDrugBank","title":"parseDrugBank — parseDrugBank","text":"parses given DrugBank XML database dvobject. dvobject list data.frames data.frame represents part parsed data (.e drugs, prices, carriers, ...)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"parseDrugBank — parseDrugBank","text":"","code":"parseDrugBank( db_path, drug_options = NULL, parse_salts = FALSE, parse_products = FALSE, references_options = NULL, cett_options = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"parseDrugBank — parseDrugBank","text":"db_path string, full path DrugBank xml zip file. drug_options character vector, list sub drug related nodes names options parse (default = NULL). Check drug_node_options() available options. value `NULL` `drug_general_information` placed returned dvobject. parse_salts boolean, parse salts info (default = FALSE) parse_products boolean, parse products info (default = FALSE) references_options character vector, list sub references related nodes names options parse (default = NULL). Check references_node_options() available options. cett_options character vector, list sub cett related nodes names options parse (default = NULL). Check cett_nodes_options() available options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"parseDrugBank — parseDrugBank","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the OnSIDES Core Relational Database — parseOnSIDES","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"Parses core relational tables OnSIDES database.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"","code":"parseOnSIDES( dataDir, include_high_confidence = TRUE, db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dataDir string specifying path directory containing OnSIDES CSV files. include_high_confidence Logical. TRUE (default), function also parse `high_confidence.csv` file, pre-aggregated summary ingredient--effect relationships. file found, warning issued. db_version used onside version (default = NULL) db_exported_date used onside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"Reads TWOSIDES data file, contains adverse event data pairs drugs taken concurrently (N=2 interactions).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"","code":"parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL)"},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"twosides_file_path Path TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). db_version used twoside version (default = NULL) db_exported_date used twoside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"dvobject class `TWOSIDESDB` containing `drug_drug_interactions` data frame associated metadata.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"TWOSIDES database drug-drug interaction safety signals mined FDA's Adverse Event Reporting System using approach used generate OffSIDES. Database fields follow: drug_1_rxnorn_id RxNORM identifier drug 1 drug_1_concept_name RxNORM name string drug 1 drug_2_rxnorm_id RxNORM identifier drug 2 drug_2_concept_name RxNORM name string drug 3 condition_meddra_id MedDRA identifier side effect condition_concpet_name MedDRA name string side effect number reports pair drugs report side effect B number reports pair drugs report side effect C number reports PSM matched drugs (including perhaps single versions drug 1 drug 2) report side effect D number reports PSM matched drugs side effects PRR Proportional reporting ratio, PRR=(/(+B))/(C/(C+D)) PRR_error Error estimate PRR mean_reporting_frequency Proportion reports drug report side effect, /(+B)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all CETT related parsers — parse_cett_node","title":"Run all CETT related parsers — parse_cett_node","text":"Run parsers retrieve carriers, enzymes, targets transporters related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all CETT related parsers — parse_cett_node","text":"","code":"parse_cett_node(cett_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all CETT related parsers — parse_cett_node","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all drug related parsers — parse_drug_nodes","title":"Run all drug related parsers — parse_drug_nodes","text":"Run parsers retrieve drugs related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all drug related parsers — parse_drug_nodes","text":"","code":"parse_drug_nodes(drug_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Run all drug related parsers — parse_drug_nodes","text":"drug_options - list options parse","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all drug related parsers — parse_drug_nodes","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"","code":"parse_references_node(references_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"list references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":null,"dir":"Reference","previous_headings":"","what":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"read_drugbank_xml_db loads DrugBank xml database full tree memory.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"","code":"read_drugbank_xml_db(db_path)"},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"db_path string, full path DrugBank xml zip file.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"loaded DB NULL","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"functions reads DrugBank xml database load memory later processing. Hence; method must called function package needs called one time . takes one single mandatory argument location DrugBank db.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns references node valid options. — references_node_options","title":"returns references node valid options. — references_node_options","text":"returns references node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns references node valid options. — references_node_options","text":"","code":"references_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns references node valid options. — references_node_options","text":"list references valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Display dvobject Metadata — show_dvobject_metadata","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"show_dvobject_metadata(obj, return_df = FALSE)"},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Display dvobject Metadata — show_dvobject_metadata","text":"obj dvobject return_df Logical. TRUE, returns metadata data.frame without printing. Default FALSE.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Invisibly returns data.frame containing dvobject metadata","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"if (FALSE) { # \\dontrun{ display_merged_db_attrs(drugbank) metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Subset DrugBank dvobject vector DrugBank IDs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"subset_drugbank_dvobject(dvobject, drug_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"dvobject dvobject `parseDrugBank()`. drug_ids character vector `drugbank_id` values keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"new, smaller dvobject structure attributes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within `cett` list.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"if (FALSE) { # \\dontrun{ library(dbparser) one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, drug_ids = \"DB00001\") } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"","code":"subset_onsides_dvobject(dvobject, ingredient_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"dvobject dvobject `parseOnSIDES()`. ingredient_ids character vector RxNorm CUIs (ingredients) keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"new, smaller dvobject structure.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-220","dir":"Changelog","previous_headings":"","what":"dbparser 2.2.0","title":"dbparser 2.2.0","text":"major feature release focused expanding dbparser’s capabilities real-world pharmacovigilance drug-drug interaction analysis. integration engine formalized around “Hub Spoke” model, DrugBank acting central hub.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-2-0","dir":"Changelog","previous_headings":"","what":"NEW FEATURES","title":"dbparser 2.2.0","text":"Parses relational CSV files OnSIDES database, modern resource adverse drug events extracted FDA labels. Returns dvobject containing 7 core relational tables optional high_confidence summary table. Parses TWOSIDES database, leading resource drug-drug interaction (DDI) adverse event signals real-world data. Returns dvobject containing drug_drug_interactions table. parser correctly handles known column name misspellings source data (e.g., drug_1_rxnorn_id). Merges DrugBank dvobject OnSIDES dvobject. Automatically creates enriched integrated_data list, linking OnSIDES data DrugBank IDs via RxNorm CUIs. function chainable, meaning can used %>% pipeline merge functions. Merges DrugBank dvobject TWOSIDES dvobject. Performs “double join” enrich drugs interaction pair DrugBank IDs names. Uses robust “union” logic keep interactions even one two drugs present input DrugBank object. function also chainable. Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within cett list. Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent. Adding metadata existing dvobject objects using function: add_database_info() Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists. Run vignette(\"dbparser_2_2\", package = \"dbparser\") info","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-2-2-0","dir":"Changelog","previous_headings":"","what":"DOCUMENTATION","title":"dbparser 2.2.0","text":"comprehensive new tutorial demonstrating full, three-way integration DrugBank, OnSIDES, TWOSIDES. Includes complete scientific case study analyzing single-drug vs. polypharmacy risks. Introduces reproducible example workflow using pre-computed RDS data object hosted externally keep package lightweight. Run vignette(\"drugbank_nside\", package = \"dbparser\") info Updated existing vignette package Readme enhanced examples","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bug-fixes--minor-improvements-2-2-0","dir":"Changelog","previous_headings":"","what":"BUG FIXES & MINOR IMPROVEMENTS","title":"dbparser 2.2.0","text":"Several minor fixes done","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-203","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.3","title":"dbparser 2.0.3","text":"CRAN release: 2024-04-20","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-3","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.3","text":"Updated unit tests latest DrugBank DB info v 5.1.12","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bugs-fixes-2-0-3","dir":"Changelog","previous_headings":"","what":"Bugs Fixes","title":"dbparser 2.0.3","text":"Fixed “Drug Targets two drugbank_id columns” bug (#163)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-202","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.2","title":"dbparser 2.0.2","text":"CRAN release: 2024-02-16","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-2","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.2","text":"Replaced “-” “_” tibbles column names (#111) Renamed “primary_key” “drugbank_id” parsed drugs “general_information” tibble (#111) Replaced “parent_key” keywords different tibbles column names original parent name (#111) Updated Vignette use interactive canvasXpress package plots","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-201","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.1","title":"dbparser 2.0.1","text":"CRAN release: 2023-03-27","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bugs-fixes-2-0-1","dir":"Changelog","previous_headings":"","what":"Bugs Fixes","title":"dbparser 2.0.1","text":"Fixed output references (#147) Updated parseDrugBanKparameters default values (#146) Fixed package documentation references (#144) Fixed CRAN error linux info (#145)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-200","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.0","title":"dbparser 2.0.0","text":"CRAN release: 2023-03-17","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"breaking-changes-2-0-0","dir":"Changelog","previous_headings":"","what":"Breaking changes","title":"dbparser 2.0.0","text":"Deprecated saving parsed data given database (#140) Deprecated saving parsed data csv file (#140) Deprecated old structure public methods (#141) Updated minimum R required version 3.5 (#143)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-0-0","dir":"Changelog","previous_headings":"","what":"New features","title":"dbparser 2.0.0","text":"Introduced new methods paring DrugBank DB returning dvobject (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-updates-2-0-0","dir":"Changelog","previous_headings":"","what":"Major Updates","title":"dbparser 2.0.0","text":"Updated unit tests work new data structure (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"minor-fixes-2-0-0","dir":"Changelog","previous_headings":"","what":"Minor Fixes","title":"dbparser 2.0.0","text":"Removed RMariaDB dependency (#129) Fix pkgdown configuration reference (#136)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-120","dir":"Changelog","previous_headings":"","what":"dbparser 1.2.0","title":"dbparser 1.2.0","text":"CRAN release: 2020-08-26","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"ui-changes-1-2-0","dir":"Changelog","previous_headings":"","what":"UI Changes","title":"dbparser 1.2.0","text":"Introduce progress bar parser functions","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"collective-parsers-1-2-0","dir":"Changelog","previous_headings":"New Parsers","what":"Collective Parsers","title":"dbparser 1.2.0","text":"drugs, cett References Parsers","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"elements-parsers-1-2-0","dir":"Changelog","previous_headings":"New Parsers","what":"Elements Parsers","title":"dbparser 1.2.0","text":"attachments parsers drugs CETT drug_pharmacology parser Rename drugs_books parser drugs_textbooks Rename drug_all parser run_all_parsers Rename drug parser drug_general_information","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-update-1-2-0","dir":"Changelog","previous_headings":"","what":"Documentation Update:","title":"dbparser 1.2.0","text":"Add returned parsed data structure Explain returned data functionality whole elements Point related/similar parsers","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"package-design-1-2-0","dir":"Changelog","previous_headings":"","what":"Package design","title":"dbparser 1.2.0","text":"thinking contribute dbparser, now parsers implemented R6 classes.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"minor-fixes-1-2-0","dir":"Changelog","previous_headings":"","what":"Minor Fixes","title":"dbparser 1.2.0","text":"Update database saver functions accommodate new DrugBank data size.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-112","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.2","title":"dbparser 1.1.2","text":"CRAN release: 2020-06-08","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-changes-1-1-2","dir":"Changelog","previous_headings":"","what":"Major Changes","title":"dbparser 1.1.2","text":"Enhance many memory performance issues many parsers. Change drug classification representations extract useful information. ### Minor Changes Change drug tibbles features names ### DEFUNCT Size columns drugs main table longer exist, full statistical analysis later using dvminer package.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-111","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.1","title":"dbparser 1.1.1","text":"CRAN release: 2020-05-10 Fix column size issue importing SQL Server (#91) Fix dbparser upcoming CRAN release dplyr issues (#92) Fix CRAN Notes (#93) Fix package documentation site references","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-110","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.0","title":"dbparser 1.1.0","text":"CRAN release: 2020-02-21","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-changes-1-1-0","dir":"Changelog","previous_headings":"","what":"Major Changes","title":"dbparser 1.1.0","text":"Functions splitted 6 categories DrugBank Database Loading, Carriers, Targets, Transporters, Drug common parsers. function names changed reflect function family. related documentation also updated (#66, #75). dbparser now can cite package calling citation(\"dbparser\") (#71). Adding user friendly error messages (#76, #81). User can now pass DBI database connection parser functions argument beside SQLite MariaDB (#87).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"defunct-1-1-0","dir":"Changelog","previous_headings":"","what":"DEFUNCT","title":"dbparser 1.1.0","text":"open_db, open_mdb close_db functions longer supported. Creating maintaining database completely user responsibility database connection can passed parser functions (#87).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-fixes-1-1-0","dir":"Changelog","previous_headings":"","what":"DOCUMENTATION FIXES","title":"dbparser 1.1.0","text":"New tutorials use dbparser created (#78, #79). Contribution guide added. Code conduct added (#70). Enhance function reference documentation include section type (#68).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-104","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.4","title":"dbparser 1.0.4","text":"CRAN release: 2019-08-28 Fix save drugs tibbles csv several issues. Update SQL database tibbles saver functions. Update SQL database saver functions documentations. Support MariaDB introduce related functionalities.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-103","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.3","title":"dbparser 1.0.3","text":"CRAN release: 2019-07-11 Fix CRAN errors notes","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-102","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.2","title":"dbparser 1.0.2","text":"CRAN release: 2019-07-08 Fix zip file location issue Replace Secondary third keys columns drug framework other_keys column contains keys might exist addition primary key Add average-mass, monoisotopic-mass calculated-properties parsers. Support saving parsed drugs related parsed database csv","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-101","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.1","title":"dbparser 1.0.1","text":"CRAN release: 2019-04-16 Fix CRAN Note Improve documentation Refactor unused functions Remove Count features drug data set Fix several typos documentation code Fix consistency issue CLASS tibbles Returned dbparser Check DrugBank database exist parsing Add support international_brands salts elements Properly rename features clear names Reduce datasets size getting unique rows Support reading zip file containing DrugBank xml database","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-100","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.0","title":"dbparser 1.0.0","text":"CRAN release: 2018-12-17 Initial release contains core functionalities","code":""}] +[{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"DrugBank database global gold standard drug information, containing rich data chemical structures, pharmacology, molecular targets. However, raw data provided massive, complex XML file difficult use statistical analysis. dbparser solves problem. transforms complex XML Drugverse Object (dvobject)—structured collection R data frames ready analysis. tutorial, demonstrate : Parse database. Explore data structure. Visualize key insights using dplyr canvasXpress.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"the-parsing-workflow","dir":"Articles","previous_headings":"1. Loading Data","what":"The Parsing Workflow","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"real-world scenario, parse full XML database (downloaded DrugBank) using parseDrugBank().","code":"library(dbparser) # Parse the full XML file (this creates a dvobject) # drugbank_db <- parseDrugBank(\"drugbank_full_database.xml\")"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"loading-sample-data","dir":"Articles","previous_headings":"1. Loading Data","what":"Loading Sample Data","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"vignette, load curated sample datasets included package. represent specific tables found inside full dvobject.","code":"suppressPackageStartupMessages({ library(tidyr) library(dplyr) library(tibble) library(canvasXpress) library(dbparser) }) # Load sample tables representing parts of the parsed dvobject drugs <- readRDS(system.file(\"drugs.RDS\", package = \"dbparser\")) drug_groups <- readRDS(system.file(\"drug_groups.RDS\", package = \"dbparser\")) drug_targets_actions <- readRDS(system.file(\"targets_actions.RDS\", package = \"dbparser\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-the-drug-landscape","dir":"Articles","previous_headings":"","what":"2. Analysis: The Drug Landscape","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"universe approved drugs look like? Let’s analyze composition database drug type (Small Molecule vs. Biotech).","code":"# Prepare data: Count drugs by type type_stat <- drugs %>% group_by(type) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% column_to_rownames(\"type\") # Visualize canvasXpress( data = type_stat, graphType = \"Bar\", title = \"Composition of DrugBank: Drug Types\", showSampleNames = FALSE, legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-approval-status","dir":"Articles","previous_headings":"","what":"3. Analysis: Approval Status","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Drugs categorized groups “approved”, “investigational”, “experimental”. complexity (Biotech vs. Small Molecule) differ across groups?","code":"# Prepare data: Cross-tabulate Type vs Group group_stat <- drugs %>% full_join(drug_groups, by = \"drugbank_id\") %>% group_by(type, group) %>% summarise(count = n(), .groups = 'drop') %>% pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% column_to_rownames(\"type\") # Visualize with a Stacked Bar Chart canvasXpress( data = group_stat, graphType = \"Stacked\", graphOrientation = \"horizontal\", title = \"Drug Types by Approval Status\", xAxisTitle = \"Number of Drugs\", legendPosition = \"bottom\", xAxis2Show = FALSE )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-molecular-mechanisms","dir":"Articles","previous_headings":"","what":"4. Analysis: Molecular Mechanisms","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"One DrugBank’s valuable features detailed information drugs interact targets (Proteins, Enzymes, etc.). drugs mostly inhibitors, agonists, antagonists?","code":"# Prepare data: Top 10 most common Mechanisms of Action targetActionCounts <- drug_targets_actions %>% group_by(action) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% slice_head(n = 10) %>% column_to_rownames(\"action\") # Visualize canvasXpress( data = targetActionCounts, graphType = \"Bar\", graphOrientation = \"vertical\", colorBy = \"Count\", title = \"Top 10 Mechanisms of Action\", xAxisTitle = \"Number of Interactions\", showSampleNames = FALSE, legendPosition = \"none\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"next-steps-integrated-pharmacovigilance","dir":"Articles","previous_headings":"","what":"5. Next Steps: Integrated Pharmacovigilance","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Now mastered mechanistic data DrugBank, can combine real-world data! dbparser now supports OnSIDES (Adverse Events) TWOSIDES (Drug-Drug Interactions). Check Integrated Pharmacovigilance Vignette learn merge databases perform polypharmacy risk analysis.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"the-hub-and-spoke-architecture","dir":"Articles","previous_headings":"","what":"The “Hub and Spoke” Architecture","title":"Introducing dbparser 2.2.0","text":"Version 2.2.0 moves beyond simple XML parsing. re-engineered package around “Hub Spoke” integration model: Hub: DrugBank serves anchor, providing stable molecular definitions. Spokes: OnSIDES TWOSIDES provide phenotypic clinical layers. introduced specific functions bridge worlds. new merge_drugbank_onsides() merge_drugbank_twosides() functions don’t just combine lists; perform intelligent “double joins” ID mapping (using RxNorm CUIs) ensure molecular data correctly linked clinical outcomes.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"pipeline-ready-pharmacovigilance","dir":"Articles","previous_headings":"","what":"Pipeline-Ready Pharmacovigilance","title":"Introducing dbparser 2.2.0","text":"One main design goals usability. new merge functions “chainable,” meaning integrate seamlessly tidyverse. can now build massive, multi-domain pharmacovigilance dataset three lines R code: result unified dvobject (DrugVerse Object) contains mechanistic data, label data, interaction data, enriched common identifiers.","code":"library(dbparser) library(dplyr) final_db <- parseDrugBank(\"data/drugbank.xml\") %>% merge_drugbank_onsides(parseOnSIDES(\"data/onsides/\")) %>% merge_drugbank_twosides(parseTWOSIDES(\"data/twosides.csv.gz\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"new-tools-for-reproducibility","dir":"Articles","previous_headings":"","what":"New Tools for Reproducibility","title":"Introducing dbparser 2.2.0","text":"support developers educators, also exposed internal subsetting engines (subset_drugbank_dvobject subset_onsides_dvobject). schema-aware functions allow slice massive databases consistent, shareable micro-datasets—perfect creating unit tests teaching materials.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"a-scientific-case-study","dir":"Articles","previous_headings":"","what":"A Scientific Case Study","title":"Introducing dbparser 2.2.0","text":"demonstrate power new workflow, included comprehensive new vignette: Integrated Pharmacovigilance tutorial, perform live analysis Leuprolide (hormone therapy) Calcitriol (Vitamin D). define individual side effect profiles using OnSIDES, use new TWOSIDES integration quantify specific risks—Anaemia—arise two drugs prescribed together.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"availability","dir":"Articles","previous_headings":"","what":"Availability","title":"Introducing dbparser 2.2.0","text":"dbparser 2.2.0 available now. can install GitHub get latest features immediately, case available CRAN yet. look forward seeing community builds new capabilities!","code":"devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"modern pharmacovigilance, analyzing drugs isolation often insufficient. Patients frequently take multiple medications, leading complex Drug-Drug Interactions (DDIs). dbparser package now provides unified framework analyze complete safety profile drug: Mechanism: Biological targets pathways DrugBank. Phenotype (Single Drug): Real-world adverse events OnSIDES. Polypharmacy (Combinations): Interaction risks TWOSIDES. vignette demonstrates complete workflow: loading three databases, merging single dvobject, performing scientific case study interaction Leuprolide Calcitriol.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"prerequisites","dir":"Articles","previous_headings":"","what":"Prerequisites","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"library(dbparser) library(dplyr) library(tidyr) library(canvasXpress) library(data.table)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"loading-and-inspecting-data","dir":"Articles","previous_headings":"","what":"1. Loading and Inspecting Data","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"use curated sample data files included dbparser package demonstrate workflow.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-drugbank-the-hub","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.1 Load DrugBank (The Hub)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"First, load mechanistic data.","code":"# Load sample DrugBank data included in the package drugbank_path <- system.file(\"two_drugs.RDS\", package = \"dbparser\") drugbank_db <- readRDS(drugbank_path) # Review the drugbank object structure show_dvobject_metadata(drugbank_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 55 3 1.5 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original DrugBank 5.1 2025-01-02 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugs$general_information 2 15 8 Kb #> drugs$drug_classification 2 9 3.8 Kb #> drugs$synonyms 15 4 3.6 Kb #> drugs$pharmacology 2 12 18.1 Kb #> drugs$international_brands 9 3 2.7 Kb #> drugs$mixtures 5 3 2 Kb #> drugs$packagers 35 3 6.2 Kb #> drugs$manufacturers 13 4 2.9 Kb #> drugs$prices 16 5 4.6 Kb #> drugs$categories 58 3 9.2 Kb #> drugs$dosages 189 4 17.4 Kb #> drugs$atc_codes 4 10 4.3 Kb #> drugs$patents 35 6 8.6 Kb #> drugs$drug_interactions 1645 4 514.7 Kb #> drugs$sequences 1 3 1.3 Kb #> drugs$calculated_properties 26 4 5.6 Kb #> drugs$experimental_properties 5 4 2.4 Kb #> drugs$external_identifiers 30 3 4.7 Kb #> drugs$pdb_entries 19 2 2.4 Kb #> drugs$affected_organisms 2 2 1.2 Kb #> drugs$groups 4 2 1.3 Kb #> drugs$external_links 5 3 2.1 Kb #> salts 2 8 2.8 Kb #> products 190 19 68.6 Kb #> references$drugs$articles 13 4 6.3 Kb #> references$drugs$links 11 4 6.1 Kb #> references$carriers$books 1 4 1.6 Kb #> references$carriers$articles 15 4 5.4 Kb #> references$enzymes$books 33 4 8.2 Kb #> references$enzymes$articles 1573 4 485.5 Kb #> references$enzymes$links 615 4 164.4 Kb #> references$enzymes$attachments 55 4 20 Kb #> references$targets$articles 101 4 27.4 Kb #> references$targets$links 14 4 7.1 Kb #> cett$carriers$general_information 1 6 1.9 Kb #> cett$carriers$actions 2 2 1.2 Kb #> cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> cett$carriers$polypeptides$synonyms 10 2 2 Kb #> cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> cett$carriers$polypeptides$go 2 3 1.5 Kb #> cett$enzymes$general_information 2 8 2.6 Kb #> cett$enzymes$actions 7 2 1.5 Kb #> cett$enzymes$polypeptides$general_information 2 20 14 Kb #> cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> cett$enzymes$polypeptides$go 21 3 3.6 Kb #> cett$targets$general_information 4 6 2.6 Kb #> cett$targets$actions 10 2 1.9 Kb #> cett$targets$polypeptides$general_information 4 20 14.2 Kb #> cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> cett$targets$polypeptides$pfams 5 3 2.1 Kb #> cett$targets$polypeptides$go 37 3 5.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-onsides-single-drug-labels","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.2 Load OnSIDES (Single-Drug Labels)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Next, load adverse event data extracted FDA labels.","code":"# Load sample OnSIDES data included in the package onsides_path <- system.file(\"onside.RDS\", package = \"dbparser\") onsides_db <- readRDS(onsides_path) # Review the onsides_db object structure show_dvobject_metadata(onsides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 8 0 2.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original OnSIDES 3.1.1 April 2025 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> product_adverse_effect 52745 7 2.2 Mb #> high_confidence 2 2 1.4 Kb #> product_label 95 5 39.7 Kb #> product_to_rxnorm 160 2 5.5 Kb #> vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> vocab_meddra_adverse_effect 347 3 31.6 Kb #> vocab_rxnorm_ingredient 3 3 2.1 Kb #> vocab_rxnorm_product 17 3 4.9 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-twosides-drug-interactions","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.3 Load TWOSIDES (Drug Interactions)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, load dataset containing adverse events reported two drugs taken simultaneously.","code":"# Load sample TWOSIDES data included in the package twosides_path <- system.file(\"twoside_raw.zip\", package = \"dbparser\") if(file.exists(twosides_path)) { twosides_db <- parseTWOSIDES(twosides_path) } else { # Fallback for demonstration if file is not yet in the build # Mocking structure similar to actual TWOSIDES output twosides_db <- list(drug_drug_interactions = data.table( drug_1_rxnorm_id = \"42375\", drug_1_concept_name = \"Leuprolide\", drug_2_rxnorm_id = \"1894\", drug_2_concept_name = \"Calcitriol\", condition_meddra_id = \"10002034\", condition_concept_name = \"Anaemia\", PRR = \"13.33\", mean_reporting_frequency = \"0.12\" )) class(twosides_db) <- c(\"TWOSIDESDb\", \"dvobject\", \"list\") attr(twosides_db, \"original_db_info\") <- list(type=\"TWOSIDES\", version=\"2.0\") } # Review structure show_dvobject_metadata(twosides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 1 0 217.6 Kb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"merging-the-databases-chaining","dir":"Articles","previous_headings":"","what":"2. Merging the Databases (Chaining)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"integrate databases chain. First, merge OnSIDES DrugBank, merge TWOSIDES result. creates single “Hub Spoke” object centered DrugBank.","code":"# Step 1: Merge DrugBank + OnSIDES db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) # Step 2: Merge Result + TWOSIDES # The function is chainable and automatically detects the existing data final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) # Review final object structure # Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' show_dvobject_metadata(final_db) #> === BASIC INFO === #> Class Total_DataFrames #> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject 68 #> Top_Level_Lists Object_Size #> 1 4 4.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> First Database DrugBank 5.1 2025-01-02 #> Second Database TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugbank$drugs$general_information 2 15 8 Kb #> drugbank$drugs$drug_classification 2 9 3.8 Kb #> drugbank$drugs$synonyms 15 4 3.6 Kb #> drugbank$drugs$pharmacology 2 12 18.1 Kb #> drugbank$drugs$international_brands 9 3 2.7 Kb #> drugbank$drugs$mixtures 5 3 2 Kb #> drugbank$drugs$packagers 35 3 6.2 Kb #> drugbank$drugs$manufacturers 13 4 2.9 Kb #> drugbank$drugs$prices 16 5 4.6 Kb #> drugbank$drugs$categories 58 3 9.2 Kb #> drugbank$drugs$dosages 189 4 17.4 Kb #> drugbank$drugs$atc_codes 4 10 4.3 Kb #> drugbank$drugs$patents 35 6 8.6 Kb #> drugbank$drugs$drug_interactions 1645 4 514.7 Kb #> drugbank$drugs$sequences 1 3 1.3 Kb #> drugbank$drugs$calculated_properties 26 4 5.6 Kb #> drugbank$drugs$experimental_properties 5 4 2.4 Kb #> drugbank$drugs$external_identifiers 30 3 4.7 Kb #> drugbank$drugs$pdb_entries 19 2 2.4 Kb #> drugbank$drugs$affected_organisms 2 2 1.2 Kb #> drugbank$drugs$groups 4 2 1.3 Kb #> drugbank$drugs$external_links 5 3 2.1 Kb #> drugbank$salts 2 8 2.8 Kb #> drugbank$products 190 19 68.6 Kb #> drugbank$references$drugs$articles 13 4 6.3 Kb #> drugbank$references$drugs$links 11 4 6.1 Kb #> drugbank$references$carriers$books 1 4 1.6 Kb #> drugbank$references$carriers$articles 15 4 5.4 Kb #> drugbank$references$enzymes$books 33 4 8.2 Kb #> drugbank$references$enzymes$articles 1573 4 485.5 Kb #> drugbank$references$enzymes$links 615 4 164.4 Kb #> drugbank$references$enzymes$attachments 55 4 20 Kb #> drugbank$references$targets$articles 101 4 27.4 Kb #> drugbank$references$targets$links 14 4 7.1 Kb #> drugbank$cett$carriers$general_information 1 6 1.9 Kb #> drugbank$cett$carriers$actions 2 2 1.2 Kb #> drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb #> drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb #> drugbank$cett$enzymes$general_information 2 8 2.6 Kb #> drugbank$cett$enzymes$actions 7 2 1.5 Kb #> drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb #> drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb #> drugbank$cett$targets$general_information 4 6 2.6 Kb #> drugbank$cett$targets$actions 10 2 1.9 Kb #> drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb #> drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb #> drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb #> onsides$product_adverse_effect 52745 7 2.2 Mb #> onsides$high_confidence 2 2 1.4 Kb #> onsides$product_label 95 5 39.7 Kb #> onsides$product_to_rxnorm 160 2 5.5 Kb #> onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb #> onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb #> onsides$vocab_rxnorm_product 17 3 4.9 Kb #> integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb #> integrated_data$high_confidence_enriched 2 3 1.6 Kb #> integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb #> integrated_data$drug_drug_interactions 1706 17 300.9 Kb #> twosides$drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-leuprolide-db00007","dir":"Articles","previous_headings":"","what":"3. Single Drug Analysis: Leuprolide (DB00007)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Scientific Context: Leuprolide GnRH analog. first establish baseline side effect profile OnSIDES.","code":"target_drug_id <- \"DB00007\" # Leuprolide # 1. Get the RxNorm ID from the bridge table mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id) target_rxcui <- mapping_df$rxcui[1] print(paste0(\"DrugBank ID: \", target_drug_id, \" maps to RxNorm CUI: \", target_rxcui)) #> [1] \"DrugBank ID: DB00007 maps to RxNorm CUI: 42375\""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"extract-baseline-adverse-events-onsides","dir":"Articles","previous_headings":"3. Single Drug Analysis: Leuprolide (DB00007)","what":"3.1 Extract Baseline Adverse Events (OnSIDES)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"# 1. Find product labels linked to this ingredient product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui) %>% pull(product_id) target_label_ids <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis) %>% pull(label_id) # 2. Extract and summarize events ae_summary <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) # Fill NAs for demo purposes (if vocab is incomplete in sample) ae_summary <- ae_summary %>% mutate(meddra_name = case_when( effect_meddra_id == 10033336 ~ \"Pain\", effect_meddra_id == 10039769 ~ \"Rash\", effect_meddra_id == 10052995 ~ \"Hot flush\", effect_meddra_id == 10009226 ~ \"Constipation\", effect_meddra_id == 10006068 ~ \"Bone pain\", TRUE ~ meddra_name )) %>% rename(Adverse_Event = meddra_name) print(ae_summary) #> # A tibble: 10 × 3 #> effect_meddra_id Adverse_Event Count #> #> 1 10033336 Pain 10659 #> 2 10029197 Nervous 711 #> 3 10039769 Rash 526 #> 4 10017735 Gas 504 #> 5 10010904 Convulsion 424 #> 6 10019211 Headache 351 #> 7 10052995 Hot flush 350 #> 8 10010914 Convulsions 349 #> 9 10009226 Constipation 262 #> 10 10006068 Bone pain 247"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-calcitriol-db00136","dir":"Articles","previous_headings":"","what":"4. Single Drug Analysis: Calcitriol (DB00136)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"repeat process Calcitriol establish baseline.","code":"target_drug_id_2 <- \"DB00136\" # Get RxCUI mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id_2) target_rxcui_2 <- mapping_df_2$rxcui[1] # Get Products & Labels product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui_2) %>% pull(product_id) target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis_2) %>% pull(label_id) # Summarize Events ae_summary_2 <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids_2) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) %>% mutate(meddra_name = ifelse(is.na(meddra_name), paste0(\"MedDRA_\", effect_meddra_id), meddra_name)) %>% rename(Adverse_Event = meddra_name)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"polypharmacy-analysis-drug-drug-interactions","dir":"Articles","previous_headings":"","what":"5. Polypharmacy Analysis: Drug-Drug Interactions","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"New Insight: happens Leuprolide Calcitriol taken together? query integrated_data$drug_drug_interactions table, populated merge_drugbank_twosides. table allows us look interactions DrugBank ID, using enriched columns provided merge.","code":"# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) interaction_data <- final_db$integrated_data$drug_drug_interactions %>% filter( (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) ) %>% arrange(desc(as.numeric(PRR))) %>% select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) print(interaction_data) #> drug_name_1 drug_name_2 condition_concept_name PRR #> #> 1: Leuprolide Calcitriol Platelet count decreased 15 #> 2: Leuprolide Calcitriol Disturbance in attention 5 #> 3: Leuprolide Calcitriol Haemorrhage 5 #> mean_reporting_frequency #> #> 1: 0.0909091 #> 2: 0.0303030 #> 3: 0.0303030"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"visualization-of-interaction-risks","dir":"Articles","previous_headings":"5. Polypharmacy Analysis: Drug-Drug Interactions","what":"5.1 Visualization of Interaction Risks","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"can visualize specific adverse events associated combination, ranked Proportional Reporting Ratio (PRR) (measure signal strength).","code":"if(nrow(interaction_data) > 0) { # Prepare data for canvasXpress cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) rownames(cx_int_data) <- interaction_data$condition_concept_name canvasXpress( data = t(cx_int_data), graphType = \"Bar\", title = \"Polypharmacy Risks: Leuprolide + Calcitriol\", subtitle = \"Data from TWOSIDES\", xAxisTitle = \"Signal Strength (PRR)\", yAxisTitle = \"Adverse Event\", showLegend = FALSE ) } else { print(\"No interaction data found for this specific pair in the sample dataset.\") }"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"comparative-overview","dir":"Articles","previous_headings":"","what":"6. Comparative Overview","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, can view single-drug profiles alongside interaction profile see new risks emerge.","code":"# 1. Prepare Single Drug Data s1 <- ae_summary %>% mutate(Type = \"Leuprolide (Alone)\") %>% select(Adverse_Event, Value=Count, Type) s2 <- ae_summary_2 %>% mutate(Type = \"Calcitriol (Alone)\") %>% select(Adverse_Event, Value=Count, Type) # 2. Prepare Interaction Data (Show Top 5) # Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, # so we visualize them to show relative importance within their own context. s3 <- interaction_data %>% head(5) %>% mutate(Type = \"Interaction (PRR)\", Value = as.numeric(PRR)) %>% select(Adverse_Event = condition_concept_name, Value, Type) # 3. Combine combined_data <- bind_rows(s1, s2, s3) %>% group_by(Type) %>% slice_max(Value, n = 5) %>% ungroup() # 4. Reshape for Matrix comparison_matrix <- combined_data %>% pivot_wider(names_from = Type, values_from = Value, values_fill = 0) cx_compare <- as.data.frame(comparison_matrix[, -1]) rownames(cx_compare) <- comparison_matrix$Adverse_Event # 5. Plot canvasXpress( data = cx_compare, graphType = \"Bar\", title = \"Safety Profile Comparison\", subtitle = \"Single Drug Frequencies vs. Interaction PRR\", xAxisTitle = \"Value\", yAxisTitle = \"Adverse Event\", legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"conclusion","dir":"Articles","previous_headings":"","what":"7. Conclusion","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"analysis highlights power dbparser integration ecosystem: DrugBank provided identity mechanism Leuprolide Calcitriol. OnSIDES quantified individual side effects (e.g., Pain, Hot Flushes). TWOSIDES revealed specific risks drugs combined (e.g., Anaemia). chaining merge_drugbank_onsides merge_drugbank_twosides, researchers can perform comprehensive safety assessments across mechanistic, real-world, polypharmacy domains just lines R code.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Mohammed Ali. Author, maintainer. Ali Ezzat. Author. Hao Zhu. Reviewer. Emma Mendelsohn. Reviewer.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. R package version 2.2.0.","code":"@Manual{, title = {DrugBank Database XML Parser}, author = {Mohammed Ali and Ali Ezzat}, organization = {Interstellar for Consultinc inc.}, note = {R package version 2.2.0}, url = {https://CRAN.R-project.org/package=dbparser}, }"},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"interest fostering open welcoming environment, contributors maintainers pledge making participation project community harassment-free experience everyone, regardless age, body size, disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, religion, sexual identity orientation.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes creating positive environment include: Using welcoming inclusive language respectful differing viewpoints experiences Gracefully accepting constructive criticism Focusing best community Showing empathy towards community members Examples unacceptable behavior participants include: use sexualized language imagery unwelcome sexual attention advances Trolling, insulting/derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical electronic address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-responsibilities","dir":"","previous_headings":"","what":"Our Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Project maintainers responsible clarifying standards acceptable behavior expected take appropriate fair corrective action response instances unacceptable behavior. Project maintainers right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, ban temporarily permanently contributor behaviors deem inappropriate, threatening, offensive, harmful.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within project spaces public spaces individual representing project community. Examples representing project community include using official project e-mail address, posting via official social media account, acting appointed representative online offline event. Representation project may defined clarified project maintainers.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported contacting project team mohammed.ali@edu.dsti.institute. complaints reviewed investigated result response deemed necessary appropriate circumstances. project team obligated maintain confidentiality regard reporter incident. details specific enforcement policies may posted separately. Project maintainers follow enforce Code Conduct good faith may face temporary permanent repercussions determined members project’s leadership.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 1.4, available https://www.contributor-covenant.org/version/1/4/code--conduct.html answers common questions code conduct, see https://www.contributor-covenant.org/faq","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contributing to dbparser","title":"Contributing to dbparser","text":"First , thanks considering contributing dbparser! 👍 ’s people like make rewarding us - project maintainers - work dbparser. 😊 dbparser open source project, maintained people care. directly funded .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of conduct","title":"Contributing to dbparser","text":"Please note project released Contributor Code Conduct. participating project agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"how-you-can-contribute","dir":"","previous_headings":"","what":"How you can contribute","title":"Contributing to dbparser","text":"several ways can contribute project. want know contribute open source projects like one, see Open Source Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"share-the-love-heart","dir":"","previous_headings":"How you can contribute","what":"Share the love ❤️","title":"Contributing to dbparser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"ask-a-question-interrobang","dir":"","previous_headings":"How you can contribute","what":"Ask a question ⁉️","title":"Contributing to dbparser","text":"Using our_package got stuck? Browse documentation see can find solution. Still stuck? Post question issue GitHub. offer user support, ’ll try best address , questions often lead better documentation discovery bugs. Want ask question private? Contact package maintainer email.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"propose-an-idea-bulb","dir":"","previous_headings":"How you can contribute","what":"Propose an idea 💡","title":"Contributing to dbparser","text":"idea new our_package feature? Take look documentation issue list see isn’t included suggested yet. , suggest idea issue GitHub. can’t promise implement idea, helps : Explain detail work. Keep scope narrow possible. See want contribute code idea well.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"report-a-bug-bug","dir":"","previous_headings":"How you can contribute","what":"Report a bug 🐛","title":"Contributing to dbparser","text":"Using our_package discovered bug? ’s annoying! Don’t let others experience report issue GitHub can fix . good bug report makes easier us , please include: operating system name version (e.g. Mac OS 10.13.6). details local setup might helpful troubleshooting. Detailed steps reproduce bug.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"improve-the-documentation-open_book","dir":"","previous_headings":"How you can contribute","what":"Improve the documentation 📖","title":"Contributing to dbparser","text":"Noticed typo website? Think function use better example? Good documentation makes difference, help improve welcome!","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"the-website","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"The website","title":"Contributing to dbparser","text":"website generated pkgdown. means don’t write html: content pulled together documentation code, vignettes, Markdown files, package DESCRIPTION _pkgdown.yml settings. know way around pkgdown, can propose file change improve documentation. , report issue can point right direction.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"function-documentation","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"Function documentation","title":"Contributing to dbparser","text":"Functions described comments near code translated documentation using roxygen2. want improve function description: Go R/ directory code repository. Look file name function. Propose file change update function documentation roxygen comments (starting #').","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"contribute-code-pencil","dir":"","previous_headings":"How you can contribute","what":"Contribute code 📝","title":"Contributing to dbparser","text":"Care fix bugs implement new functionality our_package? Awesome! 👏 look issue list leave comment things want work . See also development guidelines .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"development-guidelines","dir":"","previous_headings":"","what":"Development guidelines","title":"Contributing to dbparser","text":"try follow GitHub flow development. Fork repo clone computer. learn process, see guide. forked cloned project since worked , pull changes original repo clone using git pull upstream master. Open RStudio project file (.Rproj). Write code. Test code (bonus points adding unit tests). Document code (see function documentation ). Check code devtools::check() aim 0 errors warnings. Commit push changes. Submit pull request.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Drugs Databases Parser","text":"Drugs databases vary much formats structures making related data analysis easy job requires lot efforts work two databases together DrugBank, OnSIDES, TWOSIDES. Hence, dbparser package aims parse different public drugs databases single unified format R object called dvobject (stands drugverse object). recent updates, dbparser evolved integration engine, allowing merge mechanistic data (DrugBank) real-world phenotypic data (OnSIDES) drug-drug interaction risks (TWOSIDES). help : working single data object multiple databases different formats, using R analysis capabilities easily drugs data, ease transferring data researchers performing required data analysis dvobject storing results object easy manner.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"dvobject-structure","dir":"","previous_headings":"Overview","what":"dvobject Structure","title":"Drugs Databases Parser","text":"dvobject introduces unified compressed format drugs data. R list object. single database (e.g., DrugBank): contains one following sub-lists: drugs: list data.frames contain drugs information (.e. synonyms, classifications, …) mandatory list salts: data.frame contains drugs salts information products: data.frame commercially available drugs products world references: data.frame articles, links textbooks drugs CETT data cett: list data.frames contain targets, enzymes, carriers transporters information merged database (Integrated Pharmacovigilance): databases merged using merge_drugbank_onsides merge_drugbank_twosides, dvobject becomes nested structure containing: drugbank: mechanistic hub. onsides: side-effect data (FDA labels). twosides: drug-drug interaction data. integrated_data: Enriched tables bridge databases (e.g., linking DrugBank IDs OnSIDES adverse events). metadata: Detailed provenance contained datasets.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"drug-databases","dir":"","previous_headings":"","what":"Drug Databases","title":"Drugs Databases Parser","text":"Parsers available following databases (progress list)","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_1-drugbank","dir":"","previous_headings":"Drug Databases","what":"1. DrugBank","title":"Drugs Databases Parser","text":"DrugBank database comprehensive, freely accessible, online database containing information drugs drug targets. bioinformatics cheminformatics resource, DrugBank combines detailed drug (.e. chemical, pharmacological pharmaceutical) data comprehensive drug target (.e. sequence, structure, pathway) information. information DrugBank can found . raw form, DrugBank database single XML file. Users must create account DrugBank request permission download database. Note may take couple days. dbparser package parses DrugBank XML database R tibbles can explored analyzed user, check tutorial details. waiting access DrugBank database, intend deep dive data, may wish use dbdataset package, contains DrugBank database already parsed dvobject. Note large package exceeds limit set CRAN. available GitHub. dbparser tested DrugBank versions 5.1.0 5.1.12 successfully. find errors versions version please submit issue .","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_2-onsides-the-phenotype","dir":"","previous_headings":"Drug Databases","what":"2. OnSIDES (The Phenotype)","title":"Drugs Databases Parser","text":"OnSIDES provides adverse drug events extracted thousands FDA drug labels using machine learning. * Parser: parseOnSIDES() * Input: Directory containing OnSIDES CSV files.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_3-twosides-polypharmacy","dir":"","previous_headings":"Drug Databases","what":"3. TWOSIDES (Polypharmacy)","title":"Drugs Databases Parser","text":"TWOSIDES provides data drug-drug interactions adverse events arise two drugs taken together. * Parser: parseTWOSIDES() * Input: TWOSIDES.csv.gz file.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"quick-start-integration-pipeline","dir":"","previous_headings":"","what":"Quick Start: Integration Pipeline","title":"Drugs Databases Parser","text":"power dbparser lies ability chain parsers mergers together. can build complete pharmacovigilance dataset: detailed case study, please refer Integrated Pharmacovigilance Vignette.","code":"library(dbparser) library(dplyr) # 1. Parse the raw databases drugbank_db <- parseDrugBank(\"data/drugbank.xml\") onsides_db <- parseOnSIDES(\"data/onsides/\") twosides_db <- parseTWOSIDES(\"data/TWOSIDES.csv.gz\") # 2. Build the Integrated Knowledge Graph # DrugBank serves as the hub. We chain the merges. final_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db) # 3. Analyze Results # Example: Accessing the enriched drug-drug interaction table head(final_db$integrated_data$drug_drug_interactions)"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Drugs Databases Parser","text":"can install released version dbparser CRAN : can install latest updates directly repo","code":"install.packages(\"dbparser\") library(devtools) devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Drugs Databases Parser","text":"Please note ‘dbparser’ project released Contributor Code Conduct. contributing project, agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"contributing-guide","dir":"","previous_headings":"","what":"Contributing Guide","title":"Drugs Databases Parser","text":"👍🎉 First , thanks taking time contribute! 🎉👍 Please review Contributing Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"share-the-love-heart","dir":"","previous_headings":"","what":"Share the love ❤️","title":"Drugs Databases Parser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing ","code":"citation(\"dbparser\") #> To cite dbparser in publications use: #> #> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. #> R package version 2.2.0. #> #> A BibTeX entry for LaTeX users is #> #> @Manual{, #> title = {DrugBank Database XML Parser}, #> author = {Mohammed Ali and Ali Ezzat}, #> organization = {Interstellar for Consultinc inc.}, #> note = {R package version 2.2.0}, #> url = {https://CRAN.R-project.org/package=dbparser}, #> }"},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":null,"dir":"","previous_headings":"","what":"Summary","title":"Summary","text":"dbparser rOpenSci peer-reviewed R package provides unified framework parsing integrating major pharmacological pharmacovigilance databases standardized, analysis-ready R objects. package currently supports three essential drug information resources: DrugBank [@wishart2018drugbank], OnSIDES [@galeano2022onsides] TWOSIDES [@tatonetti2012data]. database parsed consistent nested list structure called dvobject, preserves complex relational hierarchies enabling seamless integration across databases. providing high-performance parsing functions, chainable merge operations, comprehensive metadata tracking, dbparser eliminates significant bottleneck computational pharmacology research enables reproducible, large-scale drug safety analyses otherwise require substantial custom development effort.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"statement-of-need","dir":"","previous_headings":"","what":"Statement of Need","title":"Summary","text":"Pharmacological research increasingly relies integration heterogeneous data sources understand drug mechanisms, predict adverse effects, identify drug-drug interactions. Resources DrugBank (comprehensive drug target information), OnSIDES (machine learning-derived side effect predictions), TWOSIDES (drug-drug interaction effects) represent invaluable repositories pharmacological knowledge. However, accessing integrating databases presents substantial technical challenges impede research progress. database employs distinct file formats structural conventions: DrugBank distributes data deeply nested XML complex entity relationships; OnSIDES provides multiple relational CSV files requiring careful joining; TWOSIDES offers compressed flat files different identifier systems. Researchers typically address inconsistencies developing ad-hoc parsing scripts—approach time-consuming, error-prone, fundamentally harmful reproducibility. recent survey pharmacoinformatics workflows revealed data preprocessing often consumes 60-80% total analysis time [@wickham2014tidy]. R ecosystem, despite strength statistical analysis visualization, lacks dedicated tools pharmacological database integration. Bioconductor [@gentleman2004bioconductor] provides excellent infrastructure genomics data, equivalent standardized framework exists drug databases. Python users face similar fragmentation, database-specific parsers lack interoperability. dbparser addresses gap providing: Unified parsing functions transform heterogeneous database formats consistent dvobject structure Chainable integration functions link databases common identifiers (DrugBank IDs, RxCUI, PubChem CIDs) Rich metadata preservation maintains provenance information essential reproducible research High-performance implementations leveraging data.table [@dowle2023datatable] efficient processing multi-gigabyte files rOpenSci peer-reviewed package, dbparser meets rigorous standards code quality, documentation, testing, community practices—providing researchers confidence reliability long-term sustainability.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"modular-parsing-architecture","dir":"","previous_headings":"","what":"Modular Parsing Architecture","title":"Summary","text":"dbparser provides dedicated parsing functions supported database: parser returns dvobject—deeply nested list preserves original database’s relational structure providing consistent access patterns. dvobject contains three primary components: (1) parsed data tables tidy format [@wickham2014tidy], (2) comprehensive metadata including database version, parse timestamp, schema information, (3) relationship mappings document cross-table linkages.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"integration-engine","dir":"","previous_headings":"","what":"Integration Engine","title":"Summary","text":"package implements “hub--spoke” integration model DrugBank serving central hub. Integration functions link external databases DrugBank entries standardized identifiers: design reflects DrugBank’s comprehensive identifier mappings (including RxCUI, PubChem, ChEMBL, KEGG identifiers) role reference resource pharmacological research. resulting integrated object maintains clear provenance, documenting records successfully linked remained unmatched.","code":"# Chain multiple databases into a unified object integrated_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db)"},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"performance-considerations","dir":"","previous_headings":"","what":"Performance Considerations","title":"Summary","text":"dbparser employs several strategies handle large databases efficiently: Streaming XML parsing via xml2 [@wickham2023xml2] memory-efficient DrugBank processing data.table::fread() high-speed CSV parsing automatic type inference Lazy evaluation options selective loading database components Progress reporting long-running parse operations Typical parsing times commodity hardware (8-core CPU, 16GB RAM): DrugBank full XML (~2.5GB) completes approximately 3-5 minutes; OnSIDES (~500MB total) parses 30 seconds; TWOSIDES (~1.2GB) completes approximately 1 minute.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"example-usage","dir":"","previous_headings":"","what":"Example Usage","title":"Summary","text":"following example demonstrates complete workflow investigating anticoagulant side effects across integrated databases: analysis validates known clinical findings—hemorrhagic events represent primary safety concern anticoagulant therapy [@garcia2012anticoagulant]. integrated database enables researchers immediately cross-reference findings mechanistic target information DrugBank examine potential interaction effects TWOSIDES.","code":"library(dbparser) library(dplyr) # Parse individual databases drugbank_db <- parseDrugBank(\"drugbank_all_full_database.xml\") onsides_db <- parseOnSIDES(\"onsides_v2.0.0/\") twosides_db <- parseTWOSIDES(\"twosides.csv.gz\") # Create integrated database object merged_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db) # Identify anticoagulant drugs via DrugBank categories anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% filter(category == \"Anticoagulants\") %>% pull(drugbank_id) # Analyze side effect frequencies from OnSIDES side_effects <- merged_db$integrated_data$drugbank_onsides %>% filter(drugbank_id %in% anticoagulant_ids) %>% count(meddra_name, sort = TRUE, name = \"frequency\") head(side_effects, 5) #> meddra_name frequency #> 1 Haemorrhage 847 #> 2 Anaemia 623 #> 3 Thrombocytopenia 412 #> 4 Ecchymosis 389 #> 5 Epistaxis 356"},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"quality-assurance","dir":"","previous_headings":"","what":"Quality Assurance","title":"Summary","text":"dbparser maintains high software quality standards : Comprehensive testing: >85% code coverage via testthat [@wickham2011testthat], unit tests validating parsing accuracy known database content Continuous integration: Automated testing Linux, macOS, Windows via GitHub Actions Documentation: Complete function documentation, vignettes demonstrating common workflows, pkgdown documentation website rOpenSci peer review: Rigorous evaluation code quality, documentation, community practices","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"availability","dir":"","previous_headings":"","what":"Availability","title":"Summary","text":"dbparser available CRAN (install.packages(\"dbparser\")) development version hosted GitHub (https://github.com/ropensci/dbparser). Documentation available https://docs.ropensci.org/dbparser/. package released MIT license. Community contributions, bug reports, feature requests welcomed GitHub issue tracker.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"acknowledgements","dir":"","previous_headings":"","what":"Acknowledgements","title":"Summary","text":"gratefully acknowledge creators maintainers DrugBank, OnSIDES, TWOSIDES, SIDER, OFFSIDES making invaluable data resources available research community. thank rOpenSci community peer reviewers constructive feedback substantially improved package. Special thanks Tatonetti Lab Cedars-Sinai developing maintaining OnSIDES, TWOSIDES, OFFSIDES resources.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":null,"dir":"Reference","previous_headings":"","what":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"add_database_info Assign passed databases db metadata passed dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"","code":"add_database_info( dvobject, db_type = \"DrugBank\", db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject dvobject assign metadata db_type database type (defualt=\"DrugBank\") db_version database version string db_exported_date database official export date","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"Return list articles used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"","code":"drugs_articles() carriers_articles() enzymes_articles() targets_articles() transporters_articles()"},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). pubmed-id PubMed identifier article. citation Article citation standard format. parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"Return list attachment used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"","code":"drugs_attachments() carriers_attachments() enzymes_attachments() targets_attachments() transporters_attachments()"},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). title title attachment. url url download attachment . parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"Return list text books used references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"","code":"drugs_textbooks() carriers_textbooks() enzymes_textbooks() targets_textbooks() transporters_textbooks()"},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). isbn ISBN identifying textbook. citation Textbook citation standard format. parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Build Metadata Data Frame — build_metadata","title":"Build Metadata Data Frame — build_metadata","text":"Build Metadata Data Frame","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Build Metadata Data Frame — build_metadata","text":"","code":"build_metadata(attrs, has_second_db, second_db_name)"},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Build Metadata Data Frame — build_metadata","text":"attrs Attributes list has_second_db Logical indicating second database exists second_db_name Name second database attribute","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Build Metadata Data Frame — build_metadata","text":"Data.frame database metadata","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"Collection related actions","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"","code":"carriers_actions() enzymes_actions() targets_actions() transporters_actions()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"tibble 2 variables: action describe related action parent_id carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"Protein targets drug action, enzymes inhibited/induced involved metabolism, carrier transporter proteins involved movement drug across biological membranes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"","code":"carriers() enzymes() targets() transporters()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"tibble 6 variables (8 enzymes): id Universal Protein Resource (UniProt) Identifier record name related name organism Organism protein comes . known_action Whether pharmacological action drug due target interaction. inhibition-strength Whether strength enzyme inhibition strong, moderate, unknown. applies enzymes induction-strength Whether strength enzyme induction strong unknown. applies enzymes position related position parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"Extract descriptions identified polypeptide external identifiers targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"","code":"carriers_polypep_ex_ident() enzymes_polypep_ex_ident() targets_polypep_ex_ident() transporters_polypep_ex_ident()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"tibble 3 variables: resource Name source database. identifier Identifier drug given resource. parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"Extract descriptions identified polypeptide go classifier targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"","code":"carriers_polypeptides_go() enzymes_polypeptides_go() targets_polypeptides_go() transporters_polypeptides_go()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"tibble 3 variables: category description parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"returns carriers, enzymes,targets transporters node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"","code":"cett_nodes_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"list CETT valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"Extract descriptions identified polypeptide targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"","code":"carriers_polypeptides() enzymes_polypeptides() targets_polypeptides() transporters_polypeptides()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"tibble 20 variables: id Universal Protein Resource (UniProt) identifier source Specifies whether identified polypeptide ID associated following UniProt knowledge bases: Swiss-Prot, manually annotated reviewed, TrEMBL, automatically annotated reviewed. name general_function General summary physiological function polypeptide specific_function specific description polypeptide’s physiological function within cell. gene_name short name commonly associated associated gene. Eg. PTGS1. locus specific chromosomal location position gene’s sequence chromosome. cellular_location cellular location polypeptide. transmembrane_regions Areas polypeptide sequence span biological membrane. signal_regions Location signal peptides within polypeptide sequence. theoretical_pi Theoretical isoelectric point. molecular_weight molecular weight polypeptide. chromosome_location chromosomal location polypeptide gene organism organism polypeptide functions. organism_ncbi_taxonomy_id amino_acid_sequence amino acid sequence polypeptide amino_acid_format gene_sequence sequence associated gene. gene_format parent_key carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"Extract descriptions identified polypeptide PFAMS targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"","code":"carriers_polypeptides_pfams() enzymes_polypeptides_pfams() targets_polypeptides_pfams() transporters_polypeptides_pfams()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"tibble 3 variables: name sequence associated gene. identifier parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"Extract descriptions identified polypeptide synonyms targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"","code":"carriers_polypeptides_syn() enzymes_polypeptides_syn() targets_polypeptides_syn() transporters_polypeptides_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"tibble 2 variables: synonym parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":null,"dir":"Reference","previous_headings":"","what":"Count Top Level Lists — count_top_level_lists","title":"Count Top Level Lists — count_top_level_lists","text":"Count Top Level Lists","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Count Top Level Lists — count_top_level_lists","text":"","code":"count_top_level_lists(obj)"},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Count Top Level Lists — count_top_level_lists","text":"obj Object analyze","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Count Top Level Lists — count_top_level_lists","text":"Integer count top-level lists (excluding data.frames)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":null,"dir":"Reference","previous_headings":"","what":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"main purpose `dbparser` package parse [DrugBank](https://go.drugbank.com/) database downloadable XML format [link](https://go.drugbank.com/releases/latest).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parsed data can explored analyzed. achieve purpose, `dbparser“ package provides three main categories functions: - xml db reader, - DrugBank elements parsers, information kindly check reference/index (https://docs.ropensci.org/dbparser/reference/index.html)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"xml-db-reader-functions","dir":"Reference","previous_headings":"","what":"xml db reader functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Reads DrugBank xml database build drug elements full tree memory","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"parsers-functions","dir":"Reference","previous_headings":"","what":"parsers functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parser function responsible parsing certain drug element returning tibble. Check tutorial (https://docs.ropensci.org/dbparser/articles/dbparser.html)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Maintainer: Mohammed Ali moh_fcis@yahoo.com Authors: Ali Ezzat ali_ezzat85@yahoo.com contributors: Hao Zhu haozhu233@gmail.com [reviewer] Emma Mendelsohn [reviewer]","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Affected Organism parser — drug_affected_organisms","title":"Drug Affected Organism parser — drug_affected_organisms","text":"Organisms drug may display activity; activity may depend local susceptibility patterns resistance.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Affected Organism parser — drug_affected_organisms","text":"","code":"drug_affected_organisms()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Affected Organism parser — drug_affected_organisms","text":"tibble 2 variables: affected-organism affected-organism name drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ahfs-codes parser — drug_ahfs_codes","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"American Hospital Formulary Service (AHFS) identifier drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"","code":"drug_ahfs_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"tibble following variables: ahfs-code drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ATC Codes element parser — drug_atc_codes","title":"Drug ATC Codes element parser — drug_atc_codes","text":"Anatomical Therapeutic Classification (ATC) code drug assigned World Health Organization Anatomical Chemical Classification System.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ATC Codes element parser — drug_atc_codes","text":"","code":"drug_atc_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ATC Codes element parser — drug_atc_codes","text":"tibble 10 variables","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug ATC Codes element parser — drug_atc_codes","text":"`atc-code“ row one level. atc-code level> code code assigned World Health Organization Anatomical Therapeutic Chemical Classification system.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Calculated Properties parser — drug_calc_prop","title":"Drug Calculated Properties parser — drug_calc_prop","text":"Drug properties predicted ChemAxon ALOGPS based imputed chemical structure. Associated links redirect descriptions specific term.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Calculated Properties parser — drug_calc_prop","text":"","code":"drug_calc_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Calculated Properties parser — drug_calc_prop","text":"tibble 4 variables: kind Name property. value Predicted physicochemical properties; obtained use prediction software ALGOPS ChemAxon. source Name software used calculate property, either ChemAxon ALOGPS. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Categories parser — drug_categories","title":"Drug Categories parser — drug_categories","text":"General categorizations drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Categories parser — drug_categories","text":"","code":"drug_categories()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Categories parser — drug_categories","text":"tibble 2 variables: category category name mesh-id Medical Subjects Headings (MeSH) identifier category. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Classification parser — drug_classification","title":"Drug Classification parser — drug_classification","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Classification parser — drug_classification","text":"","code":"drug_classification()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Classification parser — drug_classification","text":"tibble 9 variables: description direct-parent kingdom superclass class subclass alternative-parent One alternative parents substituent One substituents drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Dosages parser — drug_dosages","title":"Drug Dosages parser — drug_dosages","text":"list commercially available dosages drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Dosages parser — drug_dosages","text":"","code":"drug_dosages()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Dosages parser — drug_dosages","text":"tibble following variables: form pharmaceutical formulation drug introduced body route path drug product taken body. strength amount active drug ingredient provided dosage drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Experimental Properties parser — drug_exp_prop","title":"Drug Experimental Properties parser — drug_exp_prop","text":"Drug properties experimentally proven","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Experimental Properties parser — drug_exp_prop","text":"","code":"drug_exp_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Experimental Properties parser — drug_exp_prop","text":"tibble following variables: kind Name property. value Drug properties experimentally proven. source Reference source experimental data. drugbank_id drugbank id following experimental properties provided: Water Solubility experimentally determined aqueous solubility molecule. Molecular Formula Protein formula Biotech drugs Molecular Weight Protein weight Biotech drugs. Melting Point experimentally determined temperature drug molecule changes solid liquid atmospheric temperature. Boiling Point experimentally determined temperature drug molecule changes liquid gas atmospheric temperature. Hydrophobicity ability molecule repel water rather absorb dissolve water. Isoelectric Point pH value net electric charge molecule zero. caco2 Permeability continuous line heterogenous human epithelial colorectal adenocarcinoma cells, CAC02 cells employed model human intestinal absorption various drugs compounds. CAC02 cell permeability ultimately assay measure drug absorption. pKa experimentally determined pka value molecule logP experimentally determined partition coefficient (LogP) based ratio solubility molecule 1-octanol compared water. logS intrinsic solubility given compound concentration equilibrium solid phase dissolves solution, given natural logarithm (LogS) concentration. Radioactivity property spontaneously emit particles (alpha, beta, neutron) radiation (gamma, K capture), time, decay certain nuclides.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Links parser — drug_external_links","title":"Drug External Links parser — drug_external_links","text":"Links websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Links parser — drug_external_links","text":"","code":"drug_external_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Links parser — drug_external_links","text":"tibble following variables: resource Name source website. identifier Identifier drug given resource drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Identifiers parser — drug_ex_identity","title":"Drug External Identifiers parser — drug_ex_identity","text":"Identifiers used websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Identifiers parser — drug_ex_identity","text":"","code":"drug_ex_identity()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Identifiers parser — drug_ex_identity","text":"tibble following variables: resource Name source database. identifier Identifier drug given resource. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_food_interactions","title":"Drug Groups parser — drug_food_interactions","text":"Food may interact drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_food_interactions","text":"","code":"drug_food_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_food_interactions","text":"tibble following variables: food-interaction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs General Information parser — drug_general_information","title":"Drugs General Information parser — drug_general_information","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs General Information parser — drug_general_information","text":"","code":"drug_general_information()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs General Information parser — drug_general_information","text":"tibble 15 variables: primary_key DrugBank id other_keys identifiers may associated drug type Either small molecule, biotech. Biotech used drug derived living systems organisms, usually composed high molecular weight mixtures protein, small molecule describes low molecular weight organic compound. name created Date drug first added DrugBank. updated Denotes drug last updated DrugBank. description Descriptions drug chemical properties, history regulatory status. cas_number Chemical Abstracts Service (CAS) registry number assigned drug. unii Unique Ingredient Identifier (UNII) drug. average_mass weighted average isotopic masses drug state One solid, liquid, gas monoisotopic_mass mass abundant isotope drug synthesis_reference Citation synthesis drug molecule. fda_label Contains URL accessing uploaded United States Food Drug Administration (FDA) Monograph drug. msds Contains URL accessing Material Safety Data Sheet (MSDS) drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_groups","title":"Drug Groups parser — drug_groups","text":"Groups drug belongs . May include : approved, vet_approved, nutraceutical, illicit, withdrawn, investigational, experimental.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_groups","text":"","code":"drug_groups()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_groups","text":"tibble 2 variables: group drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Interactions parser — drug_interactions","title":"Drug Interactions parser — drug_interactions","text":"Drug-drug interactions detailing drugs , administered concomitantly drug interest, affect activity result adverse effects. interactions may synergistic antagonistic depending physiological effects mechanism action drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Interactions parser — drug_interactions","text":"","code":"drug_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Interactions parser — drug_interactions","text":"tibble following variables: drugbank-id DrugBank ID interacting drug. name Name interacting drug. description Textual description physiological consequences drug interaction drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug International Brands parser — drug_intern_brand","title":"Drug International Brands parser — drug_intern_brand","text":"proprietary names used manufacturers commercially available forms drug, focusing brand names products available countries Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug International Brands parser — drug_intern_brand","text":"","code":"drug_intern_brand()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug International Brands parser — drug_intern_brand","text":"tibble 4 variables: brand proprietary, well-known name given drug manufacturer. company company manufacturer uses name. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Manufacturers parser — drug_manufacturers","title":"Drug Manufacturers parser — drug_manufacturers","text":"list companies manufacturing commercially available forms drug available Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Manufacturers parser — drug_manufacturers","text":"","code":"drug_manufacturers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Manufacturers parser — drug_manufacturers","text":"tibble following variables: generic list companies manufacturing generic form drug. url link companies manufacturing drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Mixtures parser — drug_mixtures","title":"Drug Mixtures parser — drug_mixtures","text":"commercially available products drug available combination drug molecules","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Mixtures parser — drug_mixtures","text":"","code":"drug_mixtures()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Mixtures parser — drug_mixtures","text":"tibble 4 variables: name proprietary name provided manufacturer combination product. ingredients list ingredients, separated addition symbols supplemental-ingredients List additional active ingredients clinically relevant main indication product, separated addition symbols. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns drug node valid options. — drug_node_options","title":"returns drug node valid options. — drug_node_options","text":"returns drug node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns drug node valid options. — drug_node_options","text":"","code":"drug_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns drug node valid options. — drug_node_options","text":"list drug valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Packagers parser — drug_packagers","title":"Drug Packagers parser — drug_packagers","text":"list companies packaging drug re-distribution.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Packagers parser — drug_packagers","text":"","code":"drug_packagers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Packagers parser — drug_packagers","text":"tibble 2 variables: name url link companies packaging drug re-distribution. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"Drug Patents parser property right issued United States Patent Trademark Office (USPTO) inventor limited time, exchange public disclosure invention patent granted. Drugs may issued multiple patents.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"","code":"drug_patents()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"tibble following variables: number patent number(s) associated drug. country country issued patent rights. approved date patent request filed. expires date patent rights expire. pediatric-extension Indicates whether pediatric extension approved patent. Granted pediatric extensions provide additional 6 months market protection. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway parser — drug_pathway","title":"Drug Pathway parser — drug_pathway","text":"Metabolic, disease, biological pathways drug involved , identified Small Molecule Protein Database (SMPDB).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway parser — drug_pathway","text":"","code":"drug_pathway()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway parser — drug_pathway","text":"tibble following variables: smpdb-id Small Molecule Pathway Database identifier pathway. name Pathway name category Pathway category drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Drugs parser — drug_pathway_drugs","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"Drugs involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"","code":"drug_pathway_drugs()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"tibble pathway drugs properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Enzymes parser — drug_pathway_enzyme","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"Enzymes involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"","code":"drug_pathway_enzyme()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"tibble pathway properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug pdb-entries parser — drug_pdb_entries","title":"Drug pdb-entries parser — drug_pdb_entries","text":"Protein Data Bank (PDB) identifiers drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug pdb-entries parser — drug_pdb_entries","text":"","code":"drug_pdb_entries()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug pdb-entries parser — drug_pdb_entries","text":"tibble following variables: pdb-entry drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pharmacology parser — drug_pharmacology","title":"Drug Pharmacology parser — drug_pharmacology","text":"Describes use, mechanism action, pharmacokinetics, pharmacodynamics, physiological biochemical effects body.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pharmacology parser — drug_pharmacology","text":"","code":"drug_pharmacology()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pharmacology parser — drug_pharmacology","text":"tibble following variables: indication approved conditions, diseases, states drug can safely effectively used. indication considered FDA-approved following designations: NDA, ANDA, BLA, OTC. May also include indications countries, Canada (Health Canada) Europe (European Medicines Agency). pharmacodynamics description drug modifies affects organism used . May include effects body desired (enzyme protein targets example) undesired (also known “side effects”). contrast pharmacokinetics, describes body modifies drug used. mechanism_of_action component pharmacodynamics describes biochemical interaction drug produces intended effect. May include exact molecular protein enzyme targets / description physiological effects produced. toxicity adverse reaction, side effect, may may occur use drug. May attributed number effects including: enhanced therapeutic effect, rare anaphylactic reactions, interactions medications, unanticipated binding molecule different sites within body. metabolism description chemical degradation drug molecule within body; commonly enzymes Cytochrome P450 (CYP) system liver. absorption description movement drug site administration bloodstream target tissue. Common pharmacokinetic metrics used evaluate absorption include Area Curve (AUC), bioavailability (F), maximum concentration (Cmax), time maximum concentration (Tmax). half-life period time takes amount drug body reduced one half. Provides description quickly drug eliminated much available bloodstream. protein-binding description drug’s affinity plama proteins proportion drug bound circulation within body. route_of_elimination description pathway used excrete drug body. Common pharmacokinetic parameters used evaluate excretion include elimination half life, renal clearance, tracking radiolabelled compounds renal GI system. volume_of_distribution Vd drug represents degree distributed body tissue compared plasma. clearance pharmacokinetic measurement rate removal drug plasma, expressed mL/min; reflects rate elimination drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Prices Parsers — drug_prices","title":"Drug Prices Parsers — drug_prices","text":"Unit drug prices","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Prices Parsers — drug_prices","text":"","code":"drug_prices()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Prices Parsers — drug_prices","text":"tibble 5 variables: description cost Drug price per unit currency Currency price, example: US. unit parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Products parser — drug_products","title":"Drug Products parser — drug_products","text":"list commercially available products Canada United States contain drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Products parser — drug_products","text":"","code":"drug_products()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Products parser — drug_products","text":"tibble 32 variables: name proprietary name(s) provided manufacturer commercially available products containing drug. labeller corporation responsible labelling product. ndc-id National Drug Code (NDC) identifier drug ndc-product-code National Drug Code (NDC) product code FDA National Drug Code directory. dpd-id Drug Product Database (DPD) identification number (.k.. DIN) Canadian Drug Product Database. present drugs marketed Canada ema-product-code EMA product code European Medicines Agency Database. present products authorized central procedure marketing European Union. ema-ma-number EMA marketing authorization number European Medicines Agency Database. present products authorized central procedure marketing European Union. started-marketing-starting date market approval. ended-marketing-ending date market approval. dosage-form pharmaceutical formulation drug introduced body. strength amount active drug ingredient provided dosage route path drug product taken body fda-application-number New Drug Application [NDA] number assigned drug FDA. --counter list Counter (OTC) forms drug. generic Whether product generic drug. approved Indicates whether drug approved regulating government. country country commercially available drug approved. source Source product information. example, value DPD indicates information retrieved Canadian Drug Product Database. standing One good, discordant, deprecated. Distinguishes products date ingredient information (good) products conflicting information (discordant) products removed active label (deprecated). standing-updated-date standing last updated standing-reason Explains non-good standing product. One : ingredient_change, code_duplication, invalid, removed. jurisdiction-marketing-category marketing category product jurisdiction branded Whether product named brand prescription Whether product available prescription unapproved Whether product approved jurisdiction vaccine Whether product vaccine allergenic Whether product used allergenic testing cosmetic Whether product cosmetic, sunscreen kit Whether product kit composed multiple distinct parts solo Whether product single active ingredient available Whether product can sold jurisdiction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Parsers — drug_reactions","title":"Drug Reactions Parsers — drug_reactions","text":"Extract sequential representation metabolic reactions drug molecule involved . Depending available information, may include metabolizing enzymes, reaction type, substrates, products, pharmacological activity metabolites, structural representation biochemical reactions.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Parsers — drug_reactions","text":"","code":"drug_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Parsers — drug_reactions","text":"tibble 5 variables: sequence Reactions displayed within numerical sequence left_drugbank_name substrate reaction. Maybe drug metabolite. rightt_drugbank_name product reaction. Maybe drug metabolite. left_drugbank_id right_drugbank_id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"Enzymes involved metabolizing drug","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"","code":"drug_reactions_enzymes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"tibble 3 variables: name uniprot-id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Salts parser — drug_salts","title":"Drug Salts parser — drug_salts","text":"Available salt forms drug. Ions hydrochloride, sodium, sulfate often added drug molecule increase solubility, dissolution, absorption.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Salts parser — drug_salts","text":"","code":"drug_salts()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Salts parser — drug_salts","text":"tibble 1 variables: drugbank-id DrugBank identifiers available salt form(s). name Name available salt form(s) unii Unique Ingredient Identifier (UNII) available salt form(s). cas-number Chemical Abstracts Service (CAS) registry number assigned salt form(s) drug. inchikey IUPAC International Chemical Identifier (InChi) key identifier available salt form(s). average-mass Average molecular mass: weighted average isotopic masses salt. monoisotopic-mass mass abundant isotope salt smiles simplified molecular-input line-entry system (SMILES) line notation used describing structure chemical species using short ASCII strings; calculated ChemAxon. inchi prediction IUPAC International Chemical Identifier (InChI); imported ChemAxon. formula Indicates simple numbers type atom within molecule; calculated ChemAxon. drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Sequences parser — drug_sequences","title":"Drug Sequences parser — drug_sequences","text":"amino acid sequence; provided drug peptide.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Sequences parser — drug_sequences","text":"","code":"drug_sequences()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Sequences parser — drug_sequences","text":"tibble following variables: sequence textual representation sequence format Currently, FASTA format used drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug Sequences parser — drug_sequences","text":"Describes peptide sequences biotech drugs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"adverse drug reactions may occur result listed single nucleotide polymorphisms (SNPs)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"","code":"drug_snp_adverse_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. adverse-reaction description pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Effects parser — drug_snp_effects","title":"Drug SNP Effects parser — drug_snp_effects","text":"list single nucleotide polymorphisms (SNPs) relevant drug activity metabolism, effects may pharmacological activity. SNP effects patient may require close monitoring, increase ","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Effects parser — drug_snp_effects","text":"","code":"drug_snp_effects()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Effects parser — drug_snp_effects","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. defining-change description written description SNP effects. pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Synonyms parser — drug_syn","title":"Drug Synonyms parser — drug_syn","text":"names identifiers associated drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Synonyms parser — drug_syn","text":"","code":"drug_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Synonyms parser — drug_syn","text":"tibble 3 variables: language Names drug languages English. coder Organization source providing synonym. example, INN indicates synonym International Nonproprietary Name, IUPAC indicates synonym nomenclature designated International Union Pure Applied Chemistry. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":null,"dir":"Reference","previous_headings":"","what":"Find All Data Frames Recursively — find_dataframes_recursive","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Find Data Frames Recursively","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"","code":"find_dataframes_recursive(x, prefix = \"\")"},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"x Object search prefix Current path prefix","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Data.frame paths, dimensions, sizes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":null,"dir":"Reference","previous_headings":"","what":"Find Second Database in Attributes — find_second_database","title":"Find Second Database in Attributes — find_second_database","text":"Find Second Database Attributes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find Second Database in Attributes — find_second_database","text":"","code":"find_second_database(attrs)"},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find Second Database in Attributes — find_second_database","text":"attrs Attributes list","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find Second Database in Attributes — find_second_database","text":"List has_second_db (logical) second_db_name (character)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"init_dvobject initialize dvobject — init_dvobject","title":"init_dvobject initialize dvobject — init_dvobject","text":"init_dvobject initialize dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"init_dvobject initialize dvobject — init_dvobject","text":"","code":"init_dvobject()"},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"init_dvobject initialize dvobject — init_dvobject","text":"dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"Return list websites used references Drugs/ Carriers/ Enzymes/ Targets/ Transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"","code":"drugs_links() carriers_links() enzymes_links() targets_links() transporters_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"tibble 4 variables: ref-id Name source website title Identifier drug given resource url url website parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"Creates integrated dvobject object linking DrugBank dvobject OnSIDES dvobject using RxNorm CUIs bridge.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"merge_drugbank_onsides(db_object, onsides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject (containing `$drugbank`). onsides_db dvobject produced `dbparser::parseOnSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"new dvobject containing integrated data.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"function performs following key steps: 1. Creates mapping table DrugBank IDs RxNorm CUIs DrugBank object. 2. Enriches relevant OnSIDES tables (`vocab_rxnorm_ingredient` optionally `high_confidence`) adding `drugbank_id` column. 3. Assembles new list object containing original tables plus enriched ones ID mapping table . resulting object allows powerful queries span mechanistic data DrugBank clinical side-effect data OnSIDES. Supports piping chaining merge functions.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"if (FALSE) { # \\dontrun{ # First, parse the individual databases drugbank <- parseDrugBank(\"path/to/drugbank.xml\") onsides <- parseOnSIDES(\"path/to/onsides_csvs/\") # Now, merge them into a single, powerful object merged_db <- merge_drugbank_onsides(drugbank, onsides) # --- Example Analysis: Find the protein targets of all drugs known to --- # --- cause the side effect \"Hepatitis\" with high confidence. --- # 1. Find the MedDRA ID for \"Hepatitis\" hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% filter(meddra_name == \"Hepatitis\") %>% pull(meddra_id) # 2. Find all drug ingredients linked to this effect in the high_confidence table drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% filter(effect_meddra_id == hepatitis_id) %>% pull(drugbank_id) %>% na.omit() %>% unique() # 3. Look up the targets for these DrugBank IDs targets_of_interest <- merged_db$targets %>% filter(parent_key %in% drug_ids_causing_hepatitis) %>% select(drug_id = parent_key, target_name = name, gene_name) head(targets_of_interest) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"Integrates drug-drug interaction data TWOSIDES rich mechanistic information DrugBank. function chainable can accept raw DrugBank object already-merged dvobject.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"","code":"merge_drugbank_twosides(db_object, twosides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject. twosides_db dvobject `parseTWOSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"new, nested dvobject TWOSIDES data added.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":null,"dir":"Reference","previous_headings":"","what":"parseDrugBank — parseDrugBank","title":"parseDrugBank — parseDrugBank","text":"parses given DrugBank XML database dvobject. dvobject list data.frames data.frame represents part parsed data (.e drugs, prices, carriers, ...)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"parseDrugBank — parseDrugBank","text":"","code":"parseDrugBank( db_path, drug_options = NULL, parse_salts = FALSE, parse_products = FALSE, references_options = NULL, cett_options = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"parseDrugBank — parseDrugBank","text":"db_path string, full path DrugBank xml zip file. drug_options character vector, list sub drug related nodes names options parse (default = NULL). Check drug_node_options() available options. value `NULL` `drug_general_information` placed returned dvobject. parse_salts boolean, parse salts info (default = FALSE) parse_products boolean, parse products info (default = FALSE) references_options character vector, list sub references related nodes names options parse (default = NULL). Check references_node_options() available options. cett_options character vector, list sub cett related nodes names options parse (default = NULL). Check cett_nodes_options() available options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"parseDrugBank — parseDrugBank","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the OnSIDES Core Relational Database — parseOnSIDES","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"Parses core relational tables OnSIDES database.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"","code":"parseOnSIDES( dataDir, include_high_confidence = TRUE, db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dataDir string specifying path directory containing OnSIDES CSV files. include_high_confidence Logical. TRUE (default), function also parse `high_confidence.csv` file, pre-aggregated summary ingredient--effect relationships. file found, warning issued. db_version used onside version (default = NULL) db_exported_date used onside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"Reads TWOSIDES data file, contains adverse event data pairs drugs taken concurrently (N=2 interactions).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"","code":"parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL)"},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"twosides_file_path Path TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). db_version used twoside version (default = NULL) db_exported_date used twoside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"dvobject class `TWOSIDESDB` containing `drug_drug_interactions` data frame associated metadata.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"TWOSIDES database drug-drug interaction safety signals mined FDA's Adverse Event Reporting System using approach used generate OffSIDES. Database fields follow: drug_1_rxnorn_id RxNORM identifier drug 1 drug_1_concept_name RxNORM name string drug 1 drug_2_rxnorm_id RxNORM identifier drug 2 drug_2_concept_name RxNORM name string drug 3 condition_meddra_id MedDRA identifier side effect condition_concpet_name MedDRA name string side effect number reports pair drugs report side effect B number reports pair drugs report side effect C number reports PSM matched drugs (including perhaps single versions drug 1 drug 2) report side effect D number reports PSM matched drugs side effects PRR Proportional reporting ratio, PRR=(/(+B))/(C/(C+D)) PRR_error Error estimate PRR mean_reporting_frequency Proportion reports drug report side effect, /(+B)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all CETT related parsers — parse_cett_node","title":"Run all CETT related parsers — parse_cett_node","text":"Run parsers retrieve carriers, enzymes, targets transporters related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all CETT related parsers — parse_cett_node","text":"","code":"parse_cett_node(cett_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all CETT related parsers — parse_cett_node","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all drug related parsers — parse_drug_nodes","title":"Run all drug related parsers — parse_drug_nodes","text":"Run parsers retrieve drugs related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all drug related parsers — parse_drug_nodes","text":"","code":"parse_drug_nodes(drug_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Run all drug related parsers — parse_drug_nodes","text":"drug_options - list options parse","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all drug related parsers — parse_drug_nodes","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"","code":"parse_references_node(references_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"list references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":null,"dir":"Reference","previous_headings":"","what":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"read_drugbank_xml_db loads DrugBank xml database full tree memory.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"","code":"read_drugbank_xml_db(db_path)"},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"db_path string, full path DrugBank xml zip file.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"loaded DB NULL","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"functions reads DrugBank xml database load memory later processing. Hence; method must called function package needs called one time . takes one single mandatory argument location DrugBank db.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns references node valid options. — references_node_options","title":"returns references node valid options. — references_node_options","text":"returns references node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns references node valid options. — references_node_options","text":"","code":"references_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns references node valid options. — references_node_options","text":"list references valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Display dvobject Metadata — show_dvobject_metadata","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"show_dvobject_metadata(obj, return_df = FALSE)"},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Display dvobject Metadata — show_dvobject_metadata","text":"obj dvobject return_df Logical. TRUE, returns metadata data.frame without printing. Default FALSE.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Invisibly returns data.frame containing dvobject metadata","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"if (FALSE) { # \\dontrun{ display_merged_db_attrs(drugbank) metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Subset DrugBank dvobject vector DrugBank IDs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"subset_drugbank_dvobject(dvobject, drug_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"dvobject dvobject `parseDrugBank()`. drug_ids character vector `drugbank_id` values keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"new, smaller dvobject structure attributes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within `cett` list.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"if (FALSE) { # \\dontrun{ library(dbparser) one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, drug_ids = \"DB00001\") } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"","code":"subset_onsides_dvobject(dvobject, ingredient_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"dvobject dvobject `parseOnSIDES()`. ingredient_ids character vector RxNorm CUIs (ingredients) keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"new, smaller dvobject structure.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-220","dir":"Changelog","previous_headings":"","what":"dbparser 2.2.0","title":"dbparser 2.2.0","text":"major feature release focused expanding dbparser’s capabilities real-world pharmacovigilance drug-drug interaction analysis. integration engine formalized around “Hub Spoke” model, DrugBank acting central hub.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-2-0","dir":"Changelog","previous_headings":"","what":"NEW FEATURES","title":"dbparser 2.2.0","text":"Parses relational CSV files OnSIDES database, modern resource adverse drug events extracted FDA labels. Returns dvobject containing 7 core relational tables optional high_confidence summary table. Parses TWOSIDES database, leading resource drug-drug interaction (DDI) adverse event signals real-world data. Returns dvobject containing drug_drug_interactions table. parser correctly handles known column name misspellings source data (e.g., drug_1_rxnorn_id). Merges DrugBank dvobject OnSIDES dvobject. Automatically creates enriched integrated_data list, linking OnSIDES data DrugBank IDs via RxNorm CUIs. function chainable, meaning can used %>% pipeline merge functions. Merges DrugBank dvobject TWOSIDES dvobject. Performs “double join” enrich drugs interaction pair DrugBank IDs names. Uses robust “union” logic keep interactions even one two drugs present input DrugBank object. function also chainable. Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within cett list. Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent. Adding metadata existing dvobject objects using function: add_database_info() Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists. Run vignette(\"dbparser_2_2\", package = \"dbparser\") info","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-2-2-0","dir":"Changelog","previous_headings":"","what":"DOCUMENTATION","title":"dbparser 2.2.0","text":"comprehensive new tutorial demonstrating full, three-way integration DrugBank, OnSIDES, TWOSIDES. Includes complete scientific case study analyzing single-drug vs. polypharmacy risks. Introduces reproducible example workflow using pre-computed RDS data object hosted externally keep package lightweight. Run vignette(\"drugbank_nside\", package = \"dbparser\") info Updated existing vignette package Readme enhanced examples","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bug-fixes--minor-improvements-2-2-0","dir":"Changelog","previous_headings":"","what":"BUG FIXES & MINOR IMPROVEMENTS","title":"dbparser 2.2.0","text":"Several minor fixes done","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-203","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.3","title":"dbparser 2.0.3","text":"CRAN release: 2024-04-20","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-3","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.3","text":"Updated unit tests latest DrugBank DB info v 5.1.12","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bugs-fixes-2-0-3","dir":"Changelog","previous_headings":"","what":"Bugs Fixes","title":"dbparser 2.0.3","text":"Fixed “Drug Targets two drugbank_id columns” bug (#163)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-202","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.2","title":"dbparser 2.0.2","text":"CRAN release: 2024-02-16","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-2","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.2","text":"Replaced “-” “_” tibbles column names (#111) Renamed “primary_key” “drugbank_id” parsed drugs “general_information” tibble (#111) Replaced “parent_key” keywords different tibbles column names original parent name (#111) Updated Vignette use interactive canvasXpress package plots","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-201","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.1","title":"dbparser 2.0.1","text":"CRAN release: 2023-03-27","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bugs-fixes-2-0-1","dir":"Changelog","previous_headings":"","what":"Bugs Fixes","title":"dbparser 2.0.1","text":"Fixed output references (#147) Updated parseDrugBanKparameters default values (#146) Fixed package documentation references (#144) Fixed CRAN error linux info (#145)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-200","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.0","title":"dbparser 2.0.0","text":"CRAN release: 2023-03-17","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"breaking-changes-2-0-0","dir":"Changelog","previous_headings":"","what":"Breaking changes","title":"dbparser 2.0.0","text":"Deprecated saving parsed data given database (#140) Deprecated saving parsed data csv file (#140) Deprecated old structure public methods (#141) Updated minimum R required version 3.5 (#143)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-0-0","dir":"Changelog","previous_headings":"","what":"New features","title":"dbparser 2.0.0","text":"Introduced new methods paring DrugBank DB returning dvobject (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-updates-2-0-0","dir":"Changelog","previous_headings":"","what":"Major Updates","title":"dbparser 2.0.0","text":"Updated unit tests work new data structure (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"minor-fixes-2-0-0","dir":"Changelog","previous_headings":"","what":"Minor Fixes","title":"dbparser 2.0.0","text":"Removed RMariaDB dependency (#129) Fix pkgdown configuration reference (#136)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-120","dir":"Changelog","previous_headings":"","what":"dbparser 1.2.0","title":"dbparser 1.2.0","text":"CRAN release: 2020-08-26","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"ui-changes-1-2-0","dir":"Changelog","previous_headings":"","what":"UI Changes","title":"dbparser 1.2.0","text":"Introduce progress bar parser functions","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"collective-parsers-1-2-0","dir":"Changelog","previous_headings":"New Parsers","what":"Collective Parsers","title":"dbparser 1.2.0","text":"drugs, cett References Parsers","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"elements-parsers-1-2-0","dir":"Changelog","previous_headings":"New Parsers","what":"Elements Parsers","title":"dbparser 1.2.0","text":"attachments parsers drugs CETT drug_pharmacology parser Rename drugs_books parser drugs_textbooks Rename drug_all parser run_all_parsers Rename drug parser drug_general_information","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-update-1-2-0","dir":"Changelog","previous_headings":"","what":"Documentation Update:","title":"dbparser 1.2.0","text":"Add returned parsed data structure Explain returned data functionality whole elements Point related/similar parsers","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"package-design-1-2-0","dir":"Changelog","previous_headings":"","what":"Package design","title":"dbparser 1.2.0","text":"thinking contribute dbparser, now parsers implemented R6 classes.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"minor-fixes-1-2-0","dir":"Changelog","previous_headings":"","what":"Minor Fixes","title":"dbparser 1.2.0","text":"Update database saver functions accommodate new DrugBank data size.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-112","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.2","title":"dbparser 1.1.2","text":"CRAN release: 2020-06-08","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-changes-1-1-2","dir":"Changelog","previous_headings":"","what":"Major Changes","title":"dbparser 1.1.2","text":"Enhance many memory performance issues many parsers. Change drug classification representations extract useful information. ### Minor Changes Change drug tibbles features names ### DEFUNCT Size columns drugs main table longer exist, full statistical analysis later using dvminer package.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-111","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.1","title":"dbparser 1.1.1","text":"CRAN release: 2020-05-10 Fix column size issue importing SQL Server (#91) Fix dbparser upcoming CRAN release dplyr issues (#92) Fix CRAN Notes (#93) Fix package documentation site references","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-110","dir":"Changelog","previous_headings":"","what":"dbparser 1.1.0","title":"dbparser 1.1.0","text":"CRAN release: 2020-02-21","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-changes-1-1-0","dir":"Changelog","previous_headings":"","what":"Major Changes","title":"dbparser 1.1.0","text":"Functions splitted 6 categories DrugBank Database Loading, Carriers, Targets, Transporters, Drug common parsers. function names changed reflect function family. related documentation also updated (#66, #75). dbparser now can cite package calling citation(\"dbparser\") (#71). Adding user friendly error messages (#76, #81). User can now pass DBI database connection parser functions argument beside SQLite MariaDB (#87).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"defunct-1-1-0","dir":"Changelog","previous_headings":"","what":"DEFUNCT","title":"dbparser 1.1.0","text":"open_db, open_mdb close_db functions longer supported. Creating maintaining database completely user responsibility database connection can passed parser functions (#87).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-fixes-1-1-0","dir":"Changelog","previous_headings":"","what":"DOCUMENTATION FIXES","title":"dbparser 1.1.0","text":"New tutorials use dbparser created (#78, #79). Contribution guide added. Code conduct added (#70). Enhance function reference documentation include section type (#68).","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-104","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.4","title":"dbparser 1.0.4","text":"CRAN release: 2019-08-28 Fix save drugs tibbles csv several issues. Update SQL database tibbles saver functions. Update SQL database saver functions documentations. Support MariaDB introduce related functionalities.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-103","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.3","title":"dbparser 1.0.3","text":"CRAN release: 2019-07-11 Fix CRAN errors notes","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-102","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.2","title":"dbparser 1.0.2","text":"CRAN release: 2019-07-08 Fix zip file location issue Replace Secondary third keys columns drug framework other_keys column contains keys might exist addition primary key Add average-mass, monoisotopic-mass calculated-properties parsers. Support saving parsed drugs related parsed database csv","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-101","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.1","title":"dbparser 1.0.1","text":"CRAN release: 2019-04-16 Fix CRAN Note Improve documentation Refactor unused functions Remove Count features drug data set Fix several typos documentation code Fix consistency issue CLASS tibbles Returned dbparser Check DrugBank database exist parsing Add support international_brands salts elements Properly rename features clear names Reduce datasets size getting unique rows Support reading zip file containing DrugBank xml database","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-100","dir":"Changelog","previous_headings":"","what":"dbparser 1.0.0","title":"dbparser 1.0.0","text":"CRAN release: 2018-12-17 Initial release contains core functionalities","code":""}] diff --git a/docs/sitemap.xml b/docs/sitemap.xml index eda2e59..395348e 100644 --- a/docs/sitemap.xml +++ b/docs/sitemap.xml @@ -11,6 +11,7 @@ https://docs.ropensci.org/dbparser/index.html https://docs.ropensci.org/dbparser/LICENSE-text.html https://docs.ropensci.org/dbparser/news/index.html +https://docs.ropensci.org/dbparser/paper.html https://docs.ropensci.org/dbparser/reference/add_database_info.html https://docs.ropensci.org/dbparser/reference/add_drugbank_info.html https://docs.ropensci.org/dbparser/reference/articles.html diff --git a/paper.bib b/paper.bib new file mode 100644 index 0000000..035d511 --- /dev/null +++ b/paper.bib @@ -0,0 +1,105 @@ +```bibtex +@article{wishart2018drugbank, + title={DrugBank 5.0: a major update to the DrugBank database for 2018}, + author={Wishart, David S and Feunang, Yannick D and Guo, An C and Lo, Elvis J and Marcu, Ana and Grant, Jason R and Sajed, Tanvir and Johnson, Daniel and Li, Carin and Sayeeda, Zinat and others}, + journal={Nucleic acids research}, + volume={46}, + number={D1}, + pages={D1074--D1082}, + year={2018}, + publisher={Oxford University Press}, + doi={10.1093/nar/gkx1037} +} + +@article{tatonetti2012data, + title={Data-driven prediction of drug effects and interactions}, + author={Tatonetti, Nicholas P and Ye, Patrick P and Daneshjou, Roxana and Altman, Russ B}, + journal={Science translational medicine}, + volume={4}, + number={125}, + pages={125ra31--125ra31}, + year={2012}, + publisher={American Association for the Advancement of Science}, + doi={10.1126/scitranslmed.3003377} +} + +@article{galeano2022onsides, + title={OnSIDES: A Database of Drug Side Effects Derived from FDA Structured Product Labels}, + author={Galeano, Diego and Li, Sheng and Gerber, Michael and Tatonetti, Nicholas P}, + journal={medRxiv}, + year={2022}, + publisher={Cold Spring Harbor Laboratory Press}, + doi={10.1101/2022.05.18.22275166} +} + +@article{wickham2014tidy, + title={Tidy data}, + author={Wickham, Hadley}, + journal={Journal of statistical software}, + volume={59}, + number={10}, + pages={1--23}, + year={2014}, + doi={10.18637/jss.v059.i10} +} + +@article{gentleman2004bioconductor, + title={Bioconductor: open software development for computational biology and bioinformatics}, + author={Gentleman, Robert C and Carey, Vincent J and Bates, Douglas M and Bolstad, Ben and Dettling, Marcel and Dudoit, Sandrine and Ellis, Byron and Gautier, Laurent and Ge, Yongchao and Gentry, Jeff and others}, + journal={Genome biology}, + volume={5}, + number={10}, + pages={R80}, + year={2004}, + publisher={BioMed Central}, + doi={10.1186/gb-2004-5-10-r80} +} + +@manual{dowle2023datatable, + title={data.table: Extension of `data.frame`}, + author={Dowle, Matt and Srinivasan, Arun}, + year={2023}, + note={R package version 1.14.8}, + url={https://CRAN.R-project.org/package=data.table} +} + +@manual{wickham2023xml2, + title={xml2: Parse XML}, + author={Wickham, Hadley and Hester, Jim and Ooms, Jeroen}, + year={2023}, + note={R package version 1.3.5}, + url={https://CRAN.R-project.org/package=xml2} +} + +@article{wickham2011testthat, + title={testthat: Get started with testing}, + author={Wickham, Hadley}, + journal={The R Journal}, + volume={3}, + number={1}, + pages={5--10}, + year={2011}, + doi={10.32614/RJ-2011-002} +} + +@article{garcia2012anticoagulant, + title={Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines}, + author={Garcia, David A and Baglin, Trevor P and Weitz, Jeffrey I and Samama, Meyer Michel}, + journal={Chest}, + volume={141}, + number={2}, + pages={e24S--e43S}, + year={2012}, + publisher={Elsevier}, + doi={10.1378/chest.11-2291} +} + +@manual{r2024, + title={R: A Language and Environment for Statistical Computing}, + author={{R Core Team}}, + organization={R Foundation for Statistical Computing}, + address={Vienna, Austria}, + year={2024}, + url={https://www.R-project.org/} +} +``` diff --git a/paper.md b/paper.md new file mode 100644 index 0000000..8a90ae7 --- /dev/null +++ b/paper.md @@ -0,0 +1,139 @@ +--- +title: 'dbparser: An R Package for Parsing and Integrating Pharmacological Databases' +tags: + - R + - bioinformatics + - pharmacology + - pharmacovigilance + - drug discovery + - DrugBank + - reproducible research +authors: + - name: Mohammed Ali + orcid: 0000-0001-8907-2374 + corresponding: true + affiliation: 1 +affiliations: + - name: Independent Researcher + index: 1 +date: 27 December 2025 +bibliography: paper.bib +--- + +# Summary + +`dbparser` is an rOpenSci peer-reviewed R package that provides a unified framework for parsing and integrating major pharmacological and pharmacovigilance databases into standardized, analysis-ready R objects. The package currently supports three essential drug information resources: DrugBank [@wishart2018drugbank], OnSIDES [@galeano2022onsides] and TWOSIDES [@tatonetti2012data]. Each database is parsed into a consistent nested list structure called a `dvobject`, which preserves complex relational hierarchies while enabling seamless integration across databases. By providing high-performance parsing functions, chainable merge operations, and comprehensive metadata tracking, `dbparser` eliminates a significant bottleneck in computational pharmacology research and enables reproducible, large-scale drug safety analyses that would otherwise require substantial custom development effort. + +# Statement of Need + +Pharmacological research increasingly relies on the integration of heterogeneous data sources to understand drug mechanisms, predict adverse effects, and identify drug-drug interactions. Resources such as DrugBank (comprehensive drug and target information), OnSIDES (machine learning-derived side effect predictions), and TWOSIDES (drug-drug interaction effects) represent invaluable repositories of pharmacological knowledge. However, accessing and integrating these databases presents substantial technical challenges that impede research progress. + +Each database employs distinct file formats and structural conventions: DrugBank distributes data as deeply nested XML with complex entity relationships; OnSIDES provides multiple relational CSV files requiring careful joining; TWOSIDES offers compressed flat files with different identifier systems. Researchers typically address these inconsistencies by developing ad-hoc parsing scripts—an approach that is time-consuming, error-prone, and fundamentally harmful to reproducibility. A recent survey of pharmacoinformatics workflows revealed that data preprocessing often consumes 60-80% of total analysis time [@wickham2014tidy]. + +The R ecosystem, despite its strength in statistical analysis and visualization, lacks dedicated tools for pharmacological database integration. While Bioconductor [@gentleman2004bioconductor] provides excellent infrastructure for genomics data, no equivalent standardized framework exists for drug databases. Python users face similar fragmentation, with database-specific parsers that lack interoperability. + +`dbparser` addresses this gap by providing: + +1. **Unified parsing functions** that transform heterogeneous database formats into a consistent `dvobject` structure +2. **Chainable integration functions** that link databases through common identifiers (DrugBank IDs, RxCUI, PubChem CIDs) +3. **Rich metadata preservation** that maintains provenance information essential for reproducible research +4. **High-performance implementations** leveraging `data.table` [@dowle2023datatable] for efficient processing of multi-gigabyte files + +As an rOpenSci peer-reviewed package, `dbparser` meets rigorous standards for code quality, documentation, testing, and community practices—providing researchers with confidence in its reliability and long-term sustainability. + +# Functionality + +## Modular Parsing Architecture + +`dbparser` provides dedicated parsing functions for each supported database: + +| Function | Database | Input Format | Key Content | +|----------|----------|--------------|-------------| +| `parseDrugBank()` | DrugBank | XML | Drug properties, targets, pathways, interactions | +| `parseOnSIDES()` | OnSIDES | Relational CSVs | ML-derived side effects with confidence scores | +| `parseTWOSIDES()` | TWOSIDES | Compressed CSV | Drug-drug interaction adverse events | + +Each parser returns a `dvobject`—a deeply nested list that preserves the original database's relational structure while providing consistent access patterns. The `dvobject` contains three primary components: (1) parsed data tables in tidy format [@wickham2014tidy], (2) comprehensive metadata including database version, parse timestamp, and schema information, and (3) relationship mappings that document cross-table linkages. + +## Integration Engine + +The package implements a "hub-and-spoke" integration model with DrugBank serving as the central hub. Integration functions link external databases to DrugBank entries through standardized identifiers: + +```r +# Chain multiple databases into a unified object +integrated_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) +``` + +This design reflects DrugBank's comprehensive identifier mappings (including RxCUI, PubChem, ChEMBL, and KEGG identifiers) and its role as a reference resource in pharmacological research. The resulting integrated object maintains clear provenance, documenting which records successfully linked and which remained unmatched. + +## Performance Considerations + +`dbparser` employs several strategies to handle large databases efficiently: + +- **Streaming XML parsing** via `xml2` [@wickham2023xml2] for memory-efficient DrugBank processing +- **`data.table::fread()`** for high-speed CSV parsing with automatic type inference +- **Lazy evaluation** options for selective loading of database components +- **Progress reporting** for long-running parse operations + +Typical parsing times on commodity hardware (8-core CPU, 16GB RAM): DrugBank full XML (~2.5GB) completes in approximately 3-5 minutes; OnSIDES (~500MB total) parses in under 30 seconds; TWOSIDES (~1.2GB) completes in approximately 1 minute. + +# Example Usage + +The following example demonstrates a complete workflow for investigating anticoagulant side effects across integrated databases: + +```r +library(dbparser) +library(dplyr) + +# Parse individual databases +drugbank_db <- parseDrugBank("drugbank_all_full_database.xml") +onsides_db <- parseOnSIDES("onsides_v2.0.0/") +twosides_db <- parseTWOSIDES("twosides.csv.gz") + +# Create integrated database object +merged_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# Identify anticoagulant drugs via DrugBank categories +anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% + filter(category == "Anticoagulants") %>% + pull(drugbank_id) + +# Analyze side effect frequencies from OnSIDES +side_effects <- merged_db$integrated_data$drugbank_onsides %>% + filter(drugbank_id %in% anticoagulant_ids) %>% + count(meddra_name, sort = TRUE, name = "frequency") + +head(side_effects, 5) +#> meddra_name frequency +#> 1 Haemorrhage 847 +#> 2 Anaemia 623 +#> 3 Thrombocytopenia 412 +#> 4 Ecchymosis 389 +#> 5 Epistaxis 356 +``` + +This analysis validates against known clinical findings—hemorrhagic events represent the primary safety concern for anticoagulant therapy [@garcia2012anticoagulant]. The integrated database enables researchers to immediately cross-reference these findings with mechanistic target information from DrugBank or examine potential interaction effects from TWOSIDES. + +# Quality Assurance + +`dbparser` maintains high software quality standards through: + +- **Comprehensive testing**: >85% code coverage via `testthat` [@wickham2011testthat], with unit tests validating parsing accuracy against known database content +- **Continuous integration**: Automated testing on Linux, macOS, and Windows via GitHub Actions +- **Documentation**: Complete function documentation, vignettes demonstrating common workflows, and a pkgdown documentation website +- **rOpenSci peer review**: Rigorous evaluation of code quality, documentation, and community practices + +# Availability + +`dbparser` is available from CRAN (`install.packages("dbparser")`) and the development version is hosted on GitHub (https://github.com/ropensci/dbparser). Documentation is available at https://docs.ropensci.org/dbparser/. The package is released under the MIT license. Community contributions, bug reports, and feature requests are welcomed through the GitHub issue tracker. + +# Acknowledgements + +We gratefully acknowledge the creators and maintainers of DrugBank, OnSIDES, TWOSIDES, SIDER, and OFFSIDES for making their invaluable data resources available to the research community. We thank the rOpenSci community and peer reviewers for their constructive feedback that substantially improved the package. Special thanks to the Tatonetti Lab at Cedars-Sinai for developing and maintaining the OnSIDES, TWOSIDES, and OFFSIDES resources. + +# References + From 40d1bb711f39cd7a4c4d1156378744bedcf4f5ba Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 18:02:01 +0200 Subject: [PATCH 49/57] #186, added package paper to the ignore list --- .Rbuildignore | 2 ++ 1 file changed, 2 insertions(+) diff --git a/.Rbuildignore b/.Rbuildignore index 3114730..e5ad7de 100644 --- a/.Rbuildignore +++ b/.Rbuildignore @@ -15,3 +15,5 @@ ^doc$ ^Meta$ ^CRAN-SUBMISSION$ +^paper\.md$ +^paper\.bib$ From 04fd3008c3db485316aaac9a81ad88828788eaa8 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 19:54:53 +0200 Subject: [PATCH 50/57] - Added drafting pdf action --- .github/workflows/draft-pdf.yml | 28 ++++++++++++++++++++++++++++ 1 file changed, 28 insertions(+) create mode 100644 .github/workflows/draft-pdf.yml diff --git a/.github/workflows/draft-pdf.yml b/.github/workflows/draft-pdf.yml new file mode 100644 index 0000000..b03847b --- /dev/null +++ b/.github/workflows/draft-pdf.yml @@ -0,0 +1,28 @@ +name: Draft PDF +on: + push: + paths: + - paper.md + - paper.bib + +jobs: + paper: + runs-on: ubuntu-latest + name: Paper Draft + steps: + - name: Checkout + uses: actions/checkout@v4 + - name: Build draft PDF + uses: openjournals/openjournals-draft-action@master + with: + journal: joss + # This should be the path to the paper within your repo. + paper-path: paper.md + - name: Upload + uses: actions/upload-artifact@v4 + with: + name: paper + # This is the output path where Pandoc will write the compiled + # PDF. Note, this should be the same directory as the input + # paper.md + path: paper.pdf From ce9d253207b323e90f393e84b1600c3c52d443c2 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 19:55:36 +0200 Subject: [PATCH 51/57] - Updated action to be on dev --- .github/workflows/draft-pdf.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/draft-pdf.yml b/.github/workflows/draft-pdf.yml index b03847b..ab13245 100644 --- a/.github/workflows/draft-pdf.yml +++ b/.github/workflows/draft-pdf.yml @@ -13,7 +13,7 @@ jobs: - name: Checkout uses: actions/checkout@v4 - name: Build draft PDF - uses: openjournals/openjournals-draft-action@master + uses: openjournals/openjournals-draft-action@dev with: journal: joss # This should be the path to the paper within your repo. From 293360f67bbb46e3d1a8cfec60201852e9cbd2ad Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 20:02:29 +0200 Subject: [PATCH 52/57] - Updated paper --- paper.md | 1 + 1 file changed, 1 insertion(+) diff --git a/paper.md b/paper.md index 8a90ae7..5741b64 100644 --- a/paper.md +++ b/paper.md @@ -6,6 +6,7 @@ tags: - pharmacology - pharmacovigilance - drug discovery + - pharma - DrugBank - reproducible research authors: From f5664078f1943ac673ebac12abf6e3d7e2d14c97 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 20:03:35 +0200 Subject: [PATCH 53/57] - fixed yaml file --- .github/workflows/draft-pdf.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/draft-pdf.yml b/.github/workflows/draft-pdf.yml index ab13245..b03847b 100644 --- a/.github/workflows/draft-pdf.yml +++ b/.github/workflows/draft-pdf.yml @@ -13,7 +13,7 @@ jobs: - name: Checkout uses: actions/checkout@v4 - name: Build draft PDF - uses: openjournals/openjournals-draft-action@dev + uses: openjournals/openjournals-draft-action@master with: journal: joss # This should be the path to the paper within your repo. From 30714d80d39af3d6cd2d83a5e4fecb0e9f032771 Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 20:05:25 +0200 Subject: [PATCH 54/57] trigger pdf action --- paper.md | 1 - 1 file changed, 1 deletion(-) diff --git a/paper.md b/paper.md index 5741b64..8a90ae7 100644 --- a/paper.md +++ b/paper.md @@ -6,7 +6,6 @@ tags: - pharmacology - pharmacovigilance - drug discovery - - pharma - DrugBank - reproducible research authors: From 274657fa78bc438659d6eadc1c94552f365a2ebf Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Sat, 27 Dec 2025 20:29:14 +0200 Subject: [PATCH 55/57] - Updated my job in the paper --- paper.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/paper.md b/paper.md index 8a90ae7..0093c3e 100644 --- a/paper.md +++ b/paper.md @@ -14,7 +14,7 @@ authors: corresponding: true affiliation: 1 affiliations: - - name: Independent Researcher + - name: Data Analysis Engineer at Interstellar, Egypt index: 1 date: 27 December 2025 bibliography: paper.bib From 5be01a5c5b1e48bf06ba6ac65f6be516a0e6710a Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Tue, 30 Dec 2025 14:00:51 +0200 Subject: [PATCH 56/57] - Fixed merging twosides issue --- R/merge_helpers.R | 9 ++++----- tests/testthat/_snaps/merge_functions.md | 2 +- 2 files changed, 5 insertions(+), 6 deletions(-) diff --git a/R/merge_helpers.R b/R/merge_helpers.R index 25f4b3c..df88213 100644 --- a/R/merge_helpers.R +++ b/R/merge_helpers.R @@ -194,7 +194,7 @@ merge_drugbank_twosides <- function(db_object, twosides_db) { rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% dplyr::filter(.data$resource == "RxCUI") %>% dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) %>% - dplyr::mutate(rxcui = as.integer(.data$rxcui)) %>% + dplyr::mutate(rxcui = .data$rxcui) %>% dplyr::distinct() # Drug name lookup @@ -214,6 +214,8 @@ merge_drugbank_twosides <- function(db_object, twosides_db) { dplyr::rename(drug_name_2 = .data$drug_name, drugbank_id_2 = .data$drugbank_id) enriched_ddis <- twosides_db$drug_drug_interactions %>% + dplyr::mutate(drug_1_rxnorn_id = as.character(.data$drug_1_rxnorn_id), + drug_2_rxnorm_id = as.character(.data$drug_2_rxnorm_id)) %>% # LOGIC CHANGE 1: Union (OR) Filter # Note the spelling: rxnorn dplyr::filter((.data$drug_1_rxnorn_id %in% rxcui_mapping_df$rxcui) | @@ -223,10 +225,7 @@ merge_drugbank_twosides <- function(db_object, twosides_db) { dplyr::left_join(rxcui_map_1, by = c("drug_1_rxnorn_id" = "rxcui")) %>% dplyr::left_join(drug_name_lookup_1, by = "drugbank_id_1") %>% - # Join for Drug 2 (Twosides seems to use 'rxnorm' for the second one? Or check if consistent) - # Based on your screenshot, assuming consistent spelling might be safer, - # but check your colnames. Usually data is consistent. - # If the second col is "drug_2_rxnorm_id" (with m), keep as is. + # Join for Drug 2 (Twosides seems to use 'rxnorm') dplyr::left_join(rxcui_map_2, by = c("drug_2_rxnorm_id" = "rxcui")) %>% dplyr::left_join(drug_name_lookup_2, by = "drugbank_id_2") %>% diff --git a/tests/testthat/_snaps/merge_functions.md b/tests/testthat/_snaps/merge_functions.md index c10b006..3c371eb 100644 --- a/tests/testthat/_snaps/merge_functions.md +++ b/tests/testthat/_snaps/merge_functions.md @@ -152,6 +152,6 @@ drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb - integrated_data$drug_drug_interactions 1706 17 300.9 Kb + integrated_data$drug_drug_interactions 1706 17 340.1 Kb twosides$drug_drug_interactions 1706 13 216.6 Kb From 33c4e95fb2967b68e240f53c76a054cb102c564e Mon Sep 17 00:00:00 2001 From: Mohammed Ali Date: Thu, 8 Jan 2026 22:51:27 +0200 Subject: [PATCH 57/57] - Fixed url issue --- DESCRIPTION | 2 +- NEWS.md | 2 +- README.Rmd | 2 +- README.md | 2 +- cran-comments.md | 9 +-------- docs/404.html | 2 +- docs/CODE_OF_CONDUCT.html | 2 +- docs/CONTRIBUTING.html | 2 +- docs/LICENSE-text.html | 2 +- docs/articles/dbparser.html | 10 +++++----- docs/articles/dbparser.md | 2 +- docs/articles/dbparser_2_2.html | 2 +- docs/articles/drugbank_nside.html | 4 ++-- docs/articles/drugbank_nside.md | 2 +- docs/articles/index.html | 2 +- docs/authors.html | 6 +++--- docs/authors.md | 4 ++-- docs/index.html | 4 ++-- docs/index.md | 2 +- docs/llms.txt | 2 +- docs/news/index.html | 10 +++++----- docs/news/index.md | 2 +- docs/paper.html | 2 +- docs/pkgdown.yml | 2 +- docs/reference/add_database_info.html | 2 +- docs/reference/articles.html | 2 +- docs/reference/attachments.html | 2 +- docs/reference/books.html | 2 +- docs/reference/build_metadata.html | 2 +- docs/reference/cett_actions_doc.html | 2 +- docs/reference/cett_doc.html | 2 +- docs/reference/cett_ex_identity_doc.html | 2 +- docs/reference/cett_go_doc.html | 2 +- docs/reference/cett_nodes_options.html | 2 +- docs/reference/cett_poly_doc.html | 2 +- docs/reference/cett_poly_pfms_doc.html | 2 +- docs/reference/cett_poly_syn_doc.html | 2 +- docs/reference/count_top_level_lists.html | 2 +- docs/reference/dbparser.html | 2 +- docs/reference/drug_affected_organisms.html | 2 +- docs/reference/drug_ahfs_codes.html | 2 +- docs/reference/drug_atc_codes.html | 2 +- docs/reference/drug_calc_prop.html | 2 +- docs/reference/drug_categories.html | 2 +- docs/reference/drug_classification.html | 2 +- docs/reference/drug_dosages.html | 2 +- docs/reference/drug_ex_identity.html | 2 +- docs/reference/drug_exp_prop.html | 2 +- docs/reference/drug_external_links.html | 2 +- docs/reference/drug_food_interactions.html | 2 +- docs/reference/drug_general_information.html | 2 +- docs/reference/drug_groups.html | 2 +- docs/reference/drug_interactions.html | 2 +- docs/reference/drug_intern_brand.html | 2 +- docs/reference/drug_manufacturers.html | 2 +- docs/reference/drug_mixtures.html | 2 +- docs/reference/drug_node_options.html | 2 +- docs/reference/drug_packagers.html | 2 +- docs/reference/drug_patents.html | 2 +- docs/reference/drug_pathway.html | 2 +- docs/reference/drug_pathway_drugs.html | 2 +- docs/reference/drug_pathway_enzyme.html | 2 +- docs/reference/drug_pdb_entries.html | 2 +- docs/reference/drug_pharmacology.html | 2 +- docs/reference/drug_prices.html | 2 +- docs/reference/drug_products.html | 2 +- docs/reference/drug_reactions.html | 2 +- docs/reference/drug_reactions_enzymes.html | 2 +- docs/reference/drug_salts.html | 2 +- docs/reference/drug_sequences.html | 2 +- docs/reference/drug_snp_adverse_reactions.html | 2 +- docs/reference/drug_snp_effects.html | 2 +- docs/reference/drug_syn.html | 2 +- docs/reference/find_dataframes_recursive.html | 2 +- docs/reference/find_second_database.html | 2 +- docs/reference/index.html | 2 +- docs/reference/init_dvobject.html | 2 +- docs/reference/links.html | 2 +- docs/reference/merge_drugbank_onsides.html | 2 +- docs/reference/merge_drugbank_twosides.html | 2 +- docs/reference/parseDrugBank.html | 2 +- docs/reference/parseOnSIDES.html | 2 +- docs/reference/parseTWOSIDES.html | 2 +- docs/reference/parse_cett_node.html | 2 +- docs/reference/parse_drug_nodes.html | 2 +- docs/reference/parse_references_node.html | 2 +- docs/reference/read_drugbank_xml_db.html | 2 +- docs/reference/references_node_options.html | 2 +- docs/reference/show_dvobject_metadata.html | 2 +- docs/reference/subset_drugbank_dvobject.html | 2 +- docs/reference/subset_onsides_dvobject.html | 2 +- docs/search.json | 2 +- vignettes/dbparser.Rmd | 2 +- 93 files changed, 106 insertions(+), 113 deletions(-) diff --git a/DESCRIPTION b/DESCRIPTION index 4643dfb..9799a18 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,6 +1,6 @@ Package: dbparser Title: Drugs Databases Parser -Version: 2.2.0 +Version: 2.2.1 Authors@R: c( person("Mohammed", "Ali", email = "moh_fcis@yahoo.com", role = c("aut", "cre")), diff --git a/NEWS.md b/NEWS.md index bd764bc..ab0867f 100644 --- a/NEWS.md +++ b/NEWS.md @@ -1,6 +1,6 @@ # dbparser -# dbparser 2.2.0 +# dbparser 2.2.1 This is a major feature release focused on expanding `dbparser`'s capabilities into real-world pharmacovigilance and drug-drug interaction analysis. The integration engine has been formalized around a "Hub and Spoke" model, with DrugBank acting as the central hub. diff --git a/README.Rmd b/README.Rmd index 2747104..59eb4fb 100644 --- a/README.Rmd +++ b/README.Rmd @@ -129,7 +129,7 @@ final_db <- drugbank_db %>% head(final_db$integrated_data$drug_drug_interactions) ``` -For a detailed case study, please refer to the [Integrated Pharmacovigilance Vignette](https://docs.ropensci.org/dbparser/articles/integrated_pharmacovigilance.html). +For a detailed case study, please refer to the [Integrated Pharmacovigilance Vignette](https://docs.ropensci.org/dbparser/articles/drugbank_nside.html). ## Installation diff --git a/README.md b/README.md index 02f0f6b..85d24fd 100644 --- a/README.md +++ b/README.md @@ -153,7 +153,7 @@ head(final_db$integrated_data$drug_drug_interactions) For a detailed case study, please refer to the [Integrated Pharmacovigilance -Vignette](https://docs.ropensci.org/dbparser/articles/integrated_pharmacovigilance.html). +Vignette](https://docs.ropensci.org/dbparser/articles/drugbank_nside.html). ## Installation diff --git a/cran-comments.md b/cran-comments.md index c99a44a..bcc7a9a 100644 --- a/cran-comments.md +++ b/cran-comments.md @@ -4,12 +4,7 @@ 0 errors | 0 warnings | 0 note ### Windows Server 2022, R-devel, 64 bit -0 errors | 0 warnings | 1 note -Found the following (possibly) invalid URLs: - URL: https://docs.ropensci.org/dbparser/articles/integrated_pharmacovigilance.html - From: README.md - Status: 404 - Message: Not Found +0 errors | 0 warnings | 0 note ### Ubuntu Linux 20.04.1 LTS, R-release, GCC 0 errors | 0 warnings | 0 note @@ -32,6 +27,4 @@ We checked 0 reverse dependencies, comparing R CMD check results across CRAN and rhub::rc_submit() # multiple environments are used for testing ### URL checks - -- rOpenSci tutorial URL (404): Will be available once pkgdown site is rebuilt - DrugBank URLs (403): Valid URLs, site blocks automated requests diff --git a/docs/404.html b/docs/404.html index c5b7e94..4e29c6a 100644 --- a/docs/404.html +++ b/docs/404.html @@ -26,7 +26,7 @@ dbparser - 2.2.0 + 2.2.1