diff --git a/.Rbuildignore b/.Rbuildignore index 31147302..e5ad7ded 100644 --- a/.Rbuildignore +++ b/.Rbuildignore @@ -15,3 +15,5 @@ ^doc$ ^Meta$ ^CRAN-SUBMISSION$ +^paper\.md$ +^paper\.bib$ diff --git a/.github/workflows/draft-pdf.yml b/.github/workflows/draft-pdf.yml new file mode 100644 index 00000000..b03847b6 --- /dev/null +++ b/.github/workflows/draft-pdf.yml @@ -0,0 +1,28 @@ +name: Draft PDF +on: + push: + paths: + - paper.md + - paper.bib + +jobs: + paper: + runs-on: ubuntu-latest + name: Paper Draft + steps: + - name: Checkout + uses: actions/checkout@v4 + - name: Build draft PDF + uses: openjournals/openjournals-draft-action@master + with: + journal: joss + # This should be the path to the paper within your repo. + paper-path: paper.md + - name: Upload + uses: actions/upload-artifact@v4 + with: + name: paper + # This is the output path where Pandoc will write the compiled + # PDF. Note, this should be the same directory as the input + # paper.md + path: paper.pdf diff --git a/.github/workflows/rhub.yaml b/.github/workflows/rhub.yaml new file mode 100644 index 00000000..74ec7b05 --- /dev/null +++ b/.github/workflows/rhub.yaml @@ -0,0 +1,95 @@ +# R-hub's generic GitHub Actions workflow file. It's canonical location is at +# https://github.com/r-hub/actions/blob/v1/workflows/rhub.yaml +# You can update this file to a newer version using the rhub2 package: +# +# rhub::rhub_setup() +# +# It is unlikely that you need to modify this file manually. + +name: R-hub +run-name: "${{ github.event.inputs.id }}: ${{ github.event.inputs.name || format('Manually run by {0}', github.triggering_actor) }}" + +on: + workflow_dispatch: + inputs: + config: + description: 'A comma separated list of R-hub platforms to use.' + type: string + default: 'linux,windows,macos' + name: + description: 'Run name. You can leave this empty now.' + type: string + id: + description: 'Unique ID. You can leave this empty now.' + type: string + +jobs: + + setup: + runs-on: ubuntu-latest + outputs: + containers: ${{ steps.rhub-setup.outputs.containers }} + platforms: ${{ steps.rhub-setup.outputs.platforms }} + + steps: + # NO NEED TO CHECKOUT HERE + - uses: r-hub/actions/setup@v1 + with: + config: ${{ github.event.inputs.config }} + id: rhub-setup + + linux-containers: + needs: setup + if: ${{ needs.setup.outputs.containers != '[]' }} + runs-on: ubuntu-latest + name: ${{ matrix.config.label }} + strategy: + fail-fast: false + matrix: + config: ${{ fromJson(needs.setup.outputs.containers) }} + container: + image: ${{ matrix.config.container }} + + steps: + - uses: r-hub/actions/checkout@v1 + - uses: r-hub/actions/platform-info@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + - uses: r-hub/actions/setup-deps@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + - uses: r-hub/actions/run-check@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + + other-platforms: + needs: setup + if: ${{ needs.setup.outputs.platforms != '[]' }} + runs-on: ${{ matrix.config.os }} + name: ${{ matrix.config.label }} + strategy: + fail-fast: false + matrix: + config: ${{ fromJson(needs.setup.outputs.platforms) }} + + steps: + - uses: r-hub/actions/checkout@v1 + - uses: r-hub/actions/setup-r@v1 + with: + job-config: ${{ matrix.config.job-config }} + token: ${{ secrets.RHUB_TOKEN }} + - uses: r-hub/actions/platform-info@v1 + with: + token: ${{ secrets.RHUB_TOKEN }} + job-config: ${{ matrix.config.job-config }} + - uses: r-hub/actions/setup-deps@v1 + with: + job-config: ${{ matrix.config.job-config }} + token: ${{ secrets.RHUB_TOKEN }} + - uses: r-hub/actions/run-check@v1 + with: + job-config: ${{ matrix.config.job-config }} + token: ${{ secrets.RHUB_TOKEN }} diff --git a/DESCRIPTION b/DESCRIPTION index d2912ecd..9799a187 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,6 +1,6 @@ Package: dbparser Title: Drugs Databases Parser -Version: 2.0.3 +Version: 2.2.1 Authors@R: c( person("Mohammed", "Ali", email = "moh_fcis@yahoo.com", role = c("aut", "cre")), @@ -12,13 +12,15 @@ Description: This tool is for parsing public drug databases such as 'DrugBank' X License: MIT + file LICENSE Encoding: UTF-8 Imports: + data.table, dplyr, progress, purrr, tibble, tools, + utils, XML -RoxygenNote: 7.2.3 +RoxygenNote: 7.3.3 Suggests: canvasXpress, knitr, diff --git a/NAMESPACE b/NAMESPACE index 2fa538f5..33347102 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -1,10 +1,17 @@ # Generated by roxygen2: do not edit by hand +export(add_database_info) export(cett_nodes_options) export(drug_node_options) +export(merge_drugbank_onsides) +export(merge_drugbank_twosides) export(parseDrugBank) +export(parseOnSIDES) +export(parseTWOSIDES) export(references_node_options) export(show_dvobject_metadata) +export(subset_drugbank_dvobject) +export(subset_onsides_dvobject) import(dplyr) importFrom(XML,xmlApply) importFrom(XML,xmlChildren) @@ -16,7 +23,17 @@ importFrom(XML,xmlSize) importFrom(XML,xmlToDataFrame) importFrom(XML,xmlToList) importFrom(XML,xmlValue) +importFrom(data.table,fread) +importFrom(dplyr,.data) +importFrom(dplyr,distinct) +importFrom(dplyr,filter) +importFrom(dplyr,left_join) +importFrom(dplyr,mutate) +importFrom(dplyr,pull) +importFrom(dplyr,rename) +importFrom(dplyr,select) importFrom(progress,progress_bar) +importFrom(purrr,"%||%") importFrom(purrr,'%>%') importFrom(purrr,is_empty) importFrom(purrr,is_null) @@ -26,5 +43,6 @@ importFrom(tibble,as_tibble) importFrom(tibble,as_tibble_row) importFrom(tibble,tibble) importFrom(tibble,tibble_row) +importFrom(utils,object.size) importFrom(utils,stack) importFrom(utils,unzip) diff --git a/NEWS.md b/NEWS.md index 89f0cfe5..ab0867fa 100644 --- a/NEWS.md +++ b/NEWS.md @@ -1,3 +1,58 @@ +# dbparser + +# dbparser 2.2.1 + +This is a major feature release focused on expanding `dbparser`'s capabilities into real-world pharmacovigilance and drug-drug interaction analysis. The integration engine has been formalized around a "Hub and Spoke" model, with DrugBank acting as the central hub. + +## NEW FEATURES + +* **New Parser: `parseOnSIDES()`** + * Parses the relational CSV files from the OnSIDES database, a modern resource for adverse drug events extracted from FDA labels. + * Returns a `dvobject` containing the 7 core relational tables and an optional `high_confidence` summary table. + +* **New Parser: `parseTWOSIDES()`** + * Parses the TWOSIDES database, the leading resource for drug-drug interaction (DDI) adverse event signals from real-world data. + * Returns a `dvobject` containing the `drug_drug_interactions` table. + * The parser correctly handles known column name misspellings in the source data (e.g., `drug_1_rxnorn_id`). + +* **New Integration Function: `merge_drugbank_onsides()`** + * Merges a DrugBank `dvobject` with an OnSIDES `dvobject`. + * Automatically creates an enriched `integrated_data` list, linking OnSIDES data to DrugBank IDs via RxNorm CUIs. + * The function is **chainable**, meaning it can be used in a `%>%` pipeline after other merge functions. + +* **New Integration Function: `merge_drugbank_twosides()`** + * Merges a DrugBank `dvobject` with a TWOSIDES `dvobject`. + * Performs a "double join" to enrich both drugs in an interaction pair with their DrugBank IDs and names. + * Uses a robust "union" logic to keep interactions even if only one of the two drugs is present in the input DrugBank object. + * The function is also **chainable**. +* **Subset a DrugBank dvobject function: `subset_drugbank_dvobject()`** + * Intelligently filters a DrugBank dvobject to retain only the data associated with a specified list of drugbank_ids. It correctly handles the deep, +multi-level nested structure of the entire object, including the complex relationships within the `cett` list. +* **Subset an OnSIDES dvobject function: `subset_onsides_dvobject()`** + * Intelligently filters an OnSIDES dvobject by cascading filters through the +relational tables, ensuring the final subset is self-consistent. +* **Adding metadata to existing `dvobject` objects using function: `add_database_info()`** +* **Major enhancements to function `show_dvobject_metadata()`** + * Displays information about passed dbobject object including basic info, + database metadata, and all data.frames contained within nested lists. + +* Run `vignette("dbparser_2_2", package = "dbparser")` for more info + +## DOCUMENTATION + +* **New Vignette: "Integrated Pharmacovigilance"** + * A comprehensive new tutorial demonstrating a full, three-way integration of DrugBank, OnSIDES, and TWOSIDES. + * Includes a complete scientific case study analyzing single-drug vs. polypharmacy risks. + * Introduces a reproducible example workflow using a pre-computed RDS data object hosted externally to keep the package lightweight. + * Run `vignette("drugbank_nside", package = "dbparser")` for more info +* Updated existing vignette and package Readme with enhanced examples + +## BUG FIXES & MINOR IMPROVEMENTS + +* Several minor fixes are done + +--- + # dbparser 2.0.3 ## Enhancements diff --git a/R/drugbank_parser.R b/R/drugbank_parser.R index 9154474e..37e0bc01 100644 --- a/R/drugbank_parser.R +++ b/R/drugbank_parser.R @@ -80,7 +80,13 @@ parseDrugBank <- function(db_path, message("Completed loading DrugBank DB into memory") message("...........................................") pkg_env$root <- XML::xmlRoot(parsed_db) - dvobject <- add_drugbank_info(dvobject = dvobject) + dvobject <- add_database_info(dvobject = dvobject, + db_version = XML::xmlGetAttr( + node = pkg_env$root, + name = "version"), + db_exported_date = XML::xmlGetAttr( + node = pkg_env$root, + name = "exported-on")) message("parsing drugs elements") dvobject[["drugs"]] <- parse_drug_nodes(drug_options) diff --git a/R/dvobject_metadata.R b/R/dvobject_metadata.R index 4e6a0e81..b7902716 100644 --- a/R/dvobject_metadata.R +++ b/R/dvobject_metadata.R @@ -12,35 +12,207 @@ init_dvobject <- function() { } -#' add_drugbank_info -#' Add passed DrugBank db metadata to passed dvobject +#' add_database_info +#' Assign passed databases db metadata to passed dvobject +#' +#' @param dvobject dvobject to assign metadata to it +#' @param db_type database type (defualt="DrugBank") +#' @param db_version database version as string +#' @param db_exported_date database official export date #' -#' @keywords internal #' @return dvobject -add_drugbank_info <- function(dvobject) { - db_info <- attr(dvobject, "original_db_info") - - db_info[["db_type"]] <- "DrugBank" - db_info[["db_version"]] <- XML::xmlGetAttr(node = pkg_env$root, - name = "version") - db_info[["db_exported_date"]] <- XML::xmlGetAttr(node = pkg_env$root, - name = "exported-on") +#' @family utility +#' @export +#' @importFrom dplyr .data filter select rename mutate left_join +add_database_info <- function(dvobject, + db_type = "DrugBank", + db_version = NULL, + db_exported_date = NULL) { + db_info <- attr(dvobject, db_type) + db_info[["db_type"]] <- db_type + db_info[["db_version"]] <- db_version + db_info[["db_exported_date"]] <- db_exported_date attr(dvobject, "original_db_info") <- db_info + class(dvobject) <- "dvobject" dvobject } -#' init_dvobject -#' Returns data.frame with two columns (key, value) of dvobject attributes +#' Display dvobject Metadata #' -#' @param dvobject - dvobject list to show related metadata +#' Displays information about passed dbobject object including basic info, +#' database metadata, and all data.frames contained within nested lists. +#' +#' @param obj A dvobject +#' @param return_df Logical. If TRUE, returns metadata data.frame without printing. +#' Default is FALSE. +#' +#' @return Invisibly returns a data.frame containing dvobject metadata +#' +#' @examples +#' \dontrun{ +#' display_merged_db_attrs(drugbank) +#' metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) +#' } #' -#' @return data.frame -#' @family utility #' @export -show_dvobject_metadata <- function(dvobject) { - dvobject_attributes <- attr(dvobject, "original_db_info") - dvobject_attributes[["class"]] <- class(dvobject) - data.frame(Atrribute = names(dvobject_attributes), Value = stack(dvobject_attributes)[[1]]) +#' @family utility +#' @importFrom utils object.size +show_dvobject_metadata <- function(obj, return_df = FALSE) { + # Initialize return variable + metadata <- NULL + + # Validate input + attrs <- attributes(obj) + + if (is.null(attrs) || is.null(attrs$original_db_info)) { + stop("Object does not have expected database attributes (missing 'original_db_info')") + } + + # Find all dataframes in object + df_info <- find_dataframes_recursive(obj) + + # Count only top-level lists (not data.frames) + top_level_lists <- count_top_level_lists(obj) + + # Find second database if it exists + second_db_info <- find_second_database(attrs) + + # Build metadata + metadata <- build_metadata( + attrs = attrs, + has_second_db = second_db_info$has_second_db, + second_db_name = second_db_info$second_db_name + ) + + # Display output if not returning data.frame + if (!return_df) { + cat("=== BASIC INFO ===\n") + basic_info <- data.frame( + Class = paste(attrs$class, collapse = ", "), + Total_DataFrames = nrow(df_info), + Top_Level_Lists = top_level_lists, + Object_Size = format(object.size(obj), units = "auto"), + stringsAsFactors = FALSE + ) + print(basic_info) + + cat("\n=== DATABASE METADATA ===\n") + print(metadata, row.names = FALSE) + + cat("\n=== DATA.FRAMES ===\n") + print(df_info, row.names = FALSE) + } + + # Return metadata + invisible(metadata) +} + + +# Helper Functions for Display Attributes +# These are internal functions not exported to users + +#' Find All Data Frames Recursively +#' @param x Object to search +#' @param prefix Current path prefix +#' @return Data.frame with paths, dimensions, and sizes +#' @keywords internal +find_dataframes_recursive <- function(x, prefix = "") { + result <- NULL + + if (is.data.frame(x)) { + result <- data.frame( + Path = prefix, + Rows = nrow(x), + Cols = ncol(x), + Size = format(object.size(x), units = "auto"), + stringsAsFactors = FALSE + ) + } else if (is.list(x) && (length(x) > 0)) { + results <- lapply(names(x), function(name) { + new_prefix <- if (prefix == "") name else paste0(prefix, "$", name) + find_dataframes_recursive(x[[name]], new_prefix) + }) + result <- do.call(rbind, results[!sapply(results, is.null)]) + } + + result +} + +#' Count Top Level Lists +#' @param obj Object to analyze +#' @return Integer count of top-level lists (excluding data.frames) +#' @keywords internal +count_top_level_lists <- function(obj) { + sum(sapply(obj, function(x) { + (is.list(x) && !is.data.frame(x)) + })) +} + +#' Find Second Database in Attributes +#' @param attrs Attributes list +#' @return List with has_second_db (logical) and second_db_name (character) +#' @keywords internal +find_second_database <- function(attrs) { + result <- list( + has_second_db = FALSE, + second_db_name = NULL + ) + + standard_attrs <- c("names", "class", "original_db_info", "row.names") + potential_second_db <- setdiff(names(attrs), standard_attrs) + + if (length(potential_second_db) > 0) { + db_name <- potential_second_db[length(potential_second_db)] + db_attr <- attrs[[db_name]] + required_fields <- c("db_type") + + if ((is.list(db_attr)) && (any(required_fields %in% names(db_attr)))) { + result$has_second_db <- TRUE + result$second_db_name <- db_name + } + } + + result +} + +#' Build Metadata Data Frame +#' @param attrs Attributes list +#' @param has_second_db Logical indicating if second database exists +#' @param second_db_name Name of second database attribute +#' @return Data.frame with database metadata +#' @keywords internal +#' @importFrom purrr %||% +build_metadata <- function(attrs, has_second_db, second_db_name) { + metadata <- NULL + + if (has_second_db) { + metadata <- rbind( + data.frame( + Database = "First Database", + Type = attrs$DrugBankDB$db_type %||% "Unknown", + Version = attrs$DrugBankDB$db_version %||% "Unknown", + Export_Date = attrs$DrugBankDB$db_exported_date %||% "Unknown", + stringsAsFactors = FALSE + ), + data.frame( + Database = "Second Database", + Type = attrs[[second_db_name]]$db_type %||% "Unknown", + Version = attrs[[second_db_name]]$db_version %||% "Unknown", + Export_Date = attrs[[second_db_name]]$db_exported_date %||% "Unknown", + stringsAsFactors = FALSE + ) + ) + } else { + metadata <- data.frame( + Database = "Original", + Type = attrs$original_db_info$db_type %||% "Unknown", + Version = attrs$original_db_info$db_version %||% "Unknown", + Export_Date = attrs$original_db_info$db_exported_date %||% "Unknown", + stringsAsFactors = FALSE + ) + } + + metadata } diff --git a/R/merge_helpers.R b/R/merge_helpers.R new file mode 100644 index 00000000..df882137 --- /dev/null +++ b/R/merge_helpers.R @@ -0,0 +1,261 @@ +#' Merge DrugBank and OnSIDES Database Objects +#' +#' Creates an integrated dvobject object by linking DrugBank dvobject with +#' OnSIDES dvobject using RxNorm CUIs as the bridge. +#' +#' @details +#' This function performs the following key steps: +#' 1. Creates a mapping table between DrugBank IDs and RxNorm CUIs from the DrugBank object. +#' 2. Enriches the relevant OnSIDES tables (`vocab_rxnorm_ingredient` and optionally +#' `high_confidence`) by adding a `drugbank_id` column. +#' 3. Assembles a new list object containing all original tables plus the enriched ones +#' and the ID mapping table itself. +#' +#' The resulting object allows for powerful queries that span both mechanistic data from +#' DrugBank and clinical side-effect data from OnSIDES. +#' Supports piping and chaining with other merge functions. +#' +#' @param db_object A dvobject from `parseDrugBank()` OR an existing merged +#' dvobject (containing `$drugbank`). +#' @param onsides_db A dvobject produced by `dbparser::parseOnSIDES()`. +#' +#' @return A new dvobject containing the integrated data. +#' +#' @export +#' @family mergers +#' @importFrom dplyr filter select rename mutate left_join .data +#' +#' @examples +#' \dontrun{ +#' # First, parse the individual databases +#' drugbank <- parseDrugBank("path/to/drugbank.xml") +#' onsides <- parseOnSIDES("path/to/onsides_csvs/") +#' +#' # Now, merge them into a single, powerful object +#' merged_db <- merge_drugbank_onsides(drugbank, onsides) +#' +#' # --- Example Analysis: Find the protein targets of all drugs known to --- +#' # --- cause the side effect "Hepatitis" with high confidence. --- +#' +#' # 1. Find the MedDRA ID for "Hepatitis" +#' hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% +#' filter(meddra_name == "Hepatitis") %>% +#' pull(meddra_id) +#' +#' # 2. Find all drug ingredients linked to this effect in the high_confidence table +#' drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% +#' filter(effect_meddra_id == hepatitis_id) %>% +#' pull(drugbank_id) %>% +#' na.omit() %>% +#' unique() +#' +#' # 3. Look up the targets for these DrugBank IDs +#' targets_of_interest <- merged_db$targets %>% +#' filter(parent_key %in% drug_ids_causing_hepatitis) %>% +#' select(drug_id = parent_key, target_name = name, gene_name) +#' +#' head(targets_of_interest) +#' } +merge_drugbank_onsides <- function(db_object, onsides_db) { + + # --- Step 0: Input Validation and Hub Detection --- + # This logic enables the Pipe (%>%) and Chaining. + + if ("drugbank" %in% names(db_object)) { + # CASE A: Input is an already-merged object (e.g., passed via pipe from another merge) + drugbank_db <- db_object$drugbank + merged_object <- db_object # Start with existing data to preserve previous merges + } else { + # CASE B: Input is a raw DrugBank object + drugbank_db <- db_object + merged_object <- init_dvobject() + merged_object$drugbank <- db_object + attr(merged_object, "DrugBankDB") <- attr(drugbank_db, "original_db_info") + } + + # Validate the Hub + if (!inherits(drugbank_db, "dvobject") || + (!"drugs" %in% names(drugbank_db))) { + stop("`db_object` must contain a valid DrugBank dvobject.") + } + + if (!inherits(drugbank_db, "dvobject") || + (!"external_identifiers" %in% names(drugbank_db$drugs))) { + stop("`drugbank_db` must contain external_identifiers data.") + } + + # Validate the Spoke + if (!inherits(onsides_db, "dvobject") || + (!"vocab_rxnorm_ingredient" %in% names(onsides_db))) { + stop("`onsides_db` must be a valid dvobject from parseOnSIDES().") + } + + # --- Step 1: Create the Bridge (RxCUI Mapping Table) --- + message("Creating DrugBank ID <-> RxCUI mapping table...") + rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% + dplyr::filter(.data$resource == "RxCUI") %>% + dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) %>% + dplyr::distinct() + + # --- Step 2: Enrich OnSIDES Tables --- + message("Enriching OnSIDES tables with DrugBank IDs...") + + # Enrich the core ingredient vocabulary + onsides_ingredient_enriched <- onsides_db$vocab_rxnorm_ingredient %>% + dplyr::left_join(rxcui_mapping_df, by = c("rxnorm_id" = "rxcui")) + + # Optionally enrich the high_confidence table if it exists + if ("high_confidence" %in% names(onsides_db)) { + onsides_hc_enriched <- onsides_db$high_confidence %>% + dplyr::mutate(ingredient_id = as.character(.data$ingredient_id)) %>% + dplyr::left_join(rxcui_mapping_df, by = c("ingredient_id" = "rxcui")) + } + + # --- Step 3: Assemble the Final Merged Object --- + message("Assembling final merged object...") + + # Add OnSIDES structure (Initialize if needed, but append to existing) + if (is.null(merged_object$onsides)) { + merged_object$onsides <- list() + } + + # Copy all OnSIDES tables + for (name in names(onsides_db)) { + merged_object$onsides[[name]] <- onsides_db[[name]] + } + + # Ensure integrated_data list exists + if (is.null(merged_object$integrated_data)) { + merged_object$integrated_data <- list() + } + + merged_object$integrated_data[["vocab_rxnorm_ingredient_enriched"]] <- onsides_ingredient_enriched + + if (exists("onsides_hc_enriched")) { + merged_object$integrated_data[["high_confidence_enriched"]] <- onsides_hc_enriched + } + + # Add the mapping table itself for user reference + merged_object$integrated_data[["DrugBank_RxCUI_Mapping"]] <- rxcui_mapping_df + + # Update metadata + attr(merged_object, "onSideDB") <- attr(onsides_db, "original_db_info") + + # Assign a new class (Prepend to keep existing classes like DrugBankTWOSIDESDb) + class(merged_object) <- unique(c("DrugBankOnSIDESDb", class(merged_object))) + + message("Merge complete.") + merged_object +} + + +#' Merge a DrugBank dvobject with a TWOSIDES dvobject +#' +#' Integrates drug-drug interaction data from TWOSIDES with the rich mechanistic +#' information from DrugBank. This function is chainable and can accept a raw +#' DrugBank object or an already-merged dvobject. +#' +#' @param db_object A dvobject from `parseDrugBank()` or an existing merged dvobject. +#' @param twosides_db A dvobject from `parseTWOSIDES()`. +#' +#' @return A new, nested dvobject with the TWOSIDES data added. +#' +#' @importFrom dplyr filter select rename mutate left_join .data distinct +#' @family mergers +#' @export +merge_drugbank_twosides <- function(db_object, twosides_db) { + + # --- Step 0: Input Validation and Hub Detection (Pipe Friendly) --- + if ("drugbank" %in% names(db_object)) { + # Case A: Input is an already-merged object + drugbank_db <- db_object$drugbank + merged_object <- db_object + } else { + # Case B: Input is a raw DrugBank object + drugbank_db <- db_object + merged_object <- init_dvobject() + merged_object$drugbank <- db_object + attr(merged_object, "DrugBankDB") <- attr(drugbank_db, "original_db_info") + } + + # Validate inputs + if (!inherits(drugbank_db, "dvobject") || (!"drugs" %in% names(drugbank_db))) { + stop("`db_object` must contain a valid DrugBank dvobject.") + } + if (!inherits(drugbank_db, "dvobject") || (!"external_identifiers" %in% names(drugbank_db$drugs))) { + stop("`drugbank_db` must contain external_identifiers data.") + } + if (!is.list(twosides_db) || !("drug_drug_interactions" %in% names(twosides_db))) { + stop("`twosides_db` must be a valid dvobject from parseTWOSIDES().") + } + + # --- Step 1: Create Bridge --- + message("Creating DrugBank ID <-> RxCUI mapping table...") + rxcui_mapping_df <- drugbank_db$drugs$external_identifiers %>% + dplyr::filter(.data$resource == "RxCUI") %>% + dplyr::select(all_of("drugbank_id"), rxcui = .data$identifier) %>% + dplyr::mutate(rxcui = .data$rxcui) %>% + dplyr::distinct() + + # Drug name lookup + drug_name_lookup <- drugbank_db$drugs$general_information %>% + dplyr::select(all_of("drugbank_id"), drug_name = .data$name) + + # --- Step 2: Enrich TWOSIDES Data --- + message("Enriching TWOSIDES data with DrugBank information...") + + # Prepare lookup tables for double joining + rxcui_map_1 <- rxcui_mapping_df %>% dplyr::rename(drugbank_id_1 = .data$drugbank_id) + rxcui_map_2 <- rxcui_mapping_df %>% dplyr::rename(drugbank_id_2 = .data$drugbank_id) + + drug_name_lookup_1 <- drug_name_lookup %>% + dplyr::rename(drug_name_1 = .data$drug_name, drugbank_id_1 = .data$drugbank_id) + drug_name_lookup_2 <- drug_name_lookup %>% + dplyr::rename(drug_name_2 = .data$drug_name, drugbank_id_2 = .data$drugbank_id) + + enriched_ddis <- twosides_db$drug_drug_interactions %>% + dplyr::mutate(drug_1_rxnorn_id = as.character(.data$drug_1_rxnorn_id), + drug_2_rxnorm_id = as.character(.data$drug_2_rxnorm_id)) %>% + # LOGIC CHANGE 1: Union (OR) Filter + # Note the spelling: rxnorn + dplyr::filter((.data$drug_1_rxnorn_id %in% rxcui_mapping_df$rxcui) | + (.data$drug_2_rxnorm_id %in% rxcui_mapping_df$rxcui)) %>% + + # Join for Drug 1 (using 'rxnorn' spelling) + dplyr::left_join(rxcui_map_1, by = c("drug_1_rxnorn_id" = "rxcui")) %>% + dplyr::left_join(drug_name_lookup_1, by = "drugbank_id_1") %>% + + # Join for Drug 2 (Twosides seems to use 'rxnorm') + dplyr::left_join(rxcui_map_2, by = c("drug_2_rxnorm_id" = "rxcui")) %>% + dplyr::left_join(drug_name_lookup_2, by = "drugbank_id_2") %>% + + # LOGIC CHANGE 2: Keep if at least one side matched + dplyr::filter(!is.na(.data$drugbank_id_1) | !is.na(.data$drugbank_id_2)) %>% + + # LOGIC CHANGE 3: Fallback names to prevent NAs + dplyr::mutate( + drug_name_1 = dplyr::coalesce(.data$drug_name_1, .data$drug_1_concept_name), + drug_name_2 = dplyr::coalesce(.data$drug_name_2, .data$drug_2_concept_name) + ) + + # --- Step 3: Assemble Final Object --- + # Initialize integrated_data if it doesn't exist + if (is.null(merged_object$integrated_data)) { + merged_object$integrated_data <- list() + } + + # Add the new enriched table + merged_object$integrated_data$drug_drug_interactions <- enriched_ddis + + # Add raw Twosides data + merged_object$twosides <- twosides_db + + # --- Step 4: Metadata --- + attr(merged_object, "TwoSidesDB") <- attr(twosides_db, "original_db_info") + + # Prepend new class + class(merged_object) <- unique(c("DrugBankTWOSIDESDb", class(merged_object))) + + message("Merge complete.") + merged_object +} diff --git a/R/nsides_parsers.R b/R/nsides_parsers.R new file mode 100644 index 00000000..4f8485cf --- /dev/null +++ b/R/nsides_parsers.R @@ -0,0 +1,58 @@ +#' Parse the TWOSIDES Drug-Drug Interaction Database +#' +#' Reads the \href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} data file, which contains adverse event data for pairs of +#' drugs taken concurrently (N=2 interactions). +#' +#' \href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} is a database of drug-drug interaction safety signals +#' mined from the FDA's Adverse Event Reporting System using the same +#' approach as is used to generate OffSIDES. +#' +#' Database fields as follow: +#' \describe{ +#' \item{drug_1_rxnorn_id}{RxNORM identifier for drug 1} +#' \item{drug_1_concept_name}{RxNORM name string for drug 1} +#' \item{drug_2_rxnorm_id}{RxNORM identifier for drug 2} +#' \item{drug_2_concept_name}{RxNORM name string for drug 3} +#' \item{condition_meddra_id}{MedDRA identifier for the side effect} +#' \item{condition_concpet_name}{MedDRA name string for the side effect} +#' \item{A}{The number of reports for the pair of drugs that report the side effect} +#' \item{B}{The number of reports for the pair of drugs that do not report the side effect} +#' \item{C}{The number of reports for other PSM matched drugs (including perhaps the single versions of drug 1 or drug 2) that report the side effect} +#' \item{D}{The number of reports for other PSM matched drugs and other side effects} +#' \item{PRR}{Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D))} +#' \item{PRR_error}{Error estimate of the PRR} +#' \item{mean_reporting_frequency}{Proportion of reports for the drug that report the side effect, A/(A+B)} +#' } +#' +#' @param twosides_file_path Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). +#' @param db_version used twoside version (default = NULL) +#' @param db_exported_date used twoside release date (default = NULL) +#' +#' @return A dvobject of class `TWOSIDESDB` containing the `drug_drug_interactions` +#' data frame and associated metadata. +#' +#' @export +#' @family parsers +#' @importFrom data.table fread +parseTWOSIDES <- function(twosides_file_path, + db_version = NULL, + db_exported_date = NULL) { + if (!file.exists(twosides_file_path)) { + stop("TWOSIDES file not found at path: ", twosides_file_path) + } + + message("Parsing TWOSIDES drug-drug interaction data...") + twosides_data <- data.table::fread(twosides_file_path) + message("Parsing complete.") + + twosides_db <- init_dvobject() + twosides_db$drug_drug_interactions <- twosides_data + + twosides_db <- add_database_info( + dvobject = twosides_db, + db_type = "TWOSIDESDB", + db_version = db_version, + db_exported_date = db_exported_date) + + twosides_db +} diff --git a/R/onsides_parser.R b/R/onsides_parser.R new file mode 100644 index 00000000..12678aee --- /dev/null +++ b/R/onsides_parser.R @@ -0,0 +1,69 @@ + +#' Parse the OnSIDES Core Relational Database +#' +#' Parses the core relational tables from the OnSIDES database. +#' +#' @param dataDir A string specifying the path to the directory containing the +#' OnSIDES CSV files. +#' @param include_high_confidence Logical. If TRUE (the default), the function +#' will also parse the `high_confidence.csv` file, which is a pre-aggregated +#' summary of ingredient-to-effect relationships. If the file is not found, +#' a warning is issued. +#' @param db_version used onside version (default = NULL) +#' @param db_exported_date used onside release date (default = NULL) +#' +#' @return dvobject +#' @family parsers +#' +#' @export +#' @family parsers +#' @importFrom data.table fread +parseOnSIDES <- function(dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL) { + # The 7 canonical files + core_files <- c( + "product_label.csv", + "product_adverse_effect.csv", + "product_to_rxnorm.csv", + "vocab_meddra_adverse_effect.csv", + "vocab_rxnorm_ingredient.csv", + "vocab_rxnorm_product.csv", + "vocab_rxnorm_ingredient_to_product.csv" + ) + + file_paths <- file.path(dataDir, core_files) + names(file_paths) <- gsub("\\.csv$", "", core_files) + + if (!all(file.exists(file_paths))) { + missing <- core_files[!file.exists(file_paths)] + stop("Core files not found in '", dataDir, "':\n", paste(missing, collapse = "\n")) + } + + message("Parsing the 7 core OnSIDES database tables...") + db_tables <- lapply(names(file_paths), function(name) { + message("Reading ", name, ".csv ...") + data.table::fread(file_paths[[name]]) + }) + names(db_tables) <- names(file_paths) + + # --- Optional Handling of high_confidence.csv --- + if (include_high_confidence) { + hc_path <- file.path(dataDir, "high_confidence.csv") + if (file.exists(hc_path)) { + message("Reading high_confidence.csv ...") + hc_table <- data.table::fread(hc_path) + db_tables$high_confidence <- hc_table + } else { + warning("`include_high_confidence` was TRUE, but 'high_confidence.csv' was not found.") + } + } + + message("Successfully parsed OnSIDES database.") + db_tables <- add_database_info(dvobject = db_tables, + db_type = "OnSIDES", + db_version = db_version, + db_exported_date = db_exported_date) + db_tables +} diff --git a/R/utils.R b/R/utils.R new file mode 100644 index 00000000..fd8cd70f --- /dev/null +++ b/R/utils.R @@ -0,0 +1,288 @@ +#' Create a reusable helper function to process one component (carrier, enzyme, etc.) +#' @param component the component to subset from CETT +#' @param component_name componemt name +#' @param drug_ids passed drugs ids to subset for +#' +#' @importFrom dplyr .data +#' +#' @return A new, smaller dvobject with the same structure. +#' @noRd +#' @keywords internal +subset_cett_component <- function(component, component_name, drug_ids) { + new_component <- list() + + if (!is.null(component) && (NROW(component$general_information) > 0)) { + # The name of the intermediate ID, e.g., "carrier_id", "target_id" + intermediate_id_col <- paste0(sub("s$", "", component_name), "_id") + + # Step A: Filter the top-level `general_information` table by drug_id. + # This is our anchor. + general_info_filtered <- component$general_information %>% + dplyr::filter(.data$drugbank_id %in% drug_ids) + + # Step B: From this anchor, get the set of relevant intermediate IDs. + relevant_intermediate_ids <- general_info_filtered[[intermediate_id_col]] %>% + unique() + # No matching items for this component + if (length(relevant_intermediate_ids) > 0) { + # Step C: Use these intermediate IDs to filter all other tables in the component. + new_component <- list() + new_component$general_information <- general_info_filtered + new_component$actions <- component$actions %>% + dplyr::filter(.data[[intermediate_id_col]] %in% relevant_intermediate_ids) + + # Step D: Recurse into the `polypeptides` list, using the same intermediate IDs + if (!is.null(component$polypeptides)) { + new_component$polypeptides <- list() + for (poly_table_name in names(component$polypeptides)) { + poly_table <- component$polypeptides[[poly_table_name]] + if (is.data.frame(poly_table) && intermediate_id_col %in% names(poly_table)) { + new_component$polypeptides[[poly_table_name]] <- poly_table %>% + dplyr::filter(.data[[intermediate_id_col]] %in% relevant_intermediate_ids) + } + } + } + } + } + + new_component +} + + +#' Subset a DrugBank dvobject by a vector of DrugBank IDs +#' +#' @details +#' Intelligently filters a DrugBank dvobject to retain only the data associated +#' with a specified list of drugbank_ids. It correctly handles the deep, +#' multi-level nested structure of the entire object, including the complex +#' relationships within the `cett` list. +#' +#' @param dvobject The dvobject from `parseDrugBank()`. +#' @param drug_ids A character vector of `drugbank_id` values to keep. +#' +#' @return A new, smaller dvobject with the same structure and attributes. +#' +#' @export +#' @importFrom dplyr filter .data +#' +#' @examples +#' \dontrun{ +#' library(dbparser) +#' one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, +#' drug_ids = "DB00001") +#' } +#' @family utility +subset_drugbank_dvobject <- function(dvobject, drug_ids) { + new_dvobject <- NULL + + if ((length(drug_ids) == 0) || (sum(nchar(drug_ids)) == 0)) { + warning("`drug_ids` is empty. Returning NULL") + } else { + new_dvobject <- init_dvobject() + + # --- 1. Filter the `drugs` list (many sub-tables) --- + if (!is.null(dvobject$drugs)) { + message("Subsetting `drugs` list...") + new_dvobject$drugs <- list() + for (name in names(dvobject$drugs)) { + sub_table <- dvobject$drugs[[name]] + # Most tables here link directly via drugbank_id + if (is.data.frame(sub_table) && ("drugbank_id" %in% names(sub_table))) { + filtered_subtable<- sub_table %>% + dplyr::filter(.data$drugbank_id %in% drug_ids) + if (NROW(filtered_subtable) > 0) { + new_dvobject$drugs[[name]] <- filtered_subtable + } + } + } + } + + # --- 2. Filter the `salts`, `products` data.frames --- + for (name in c("salts", "products")) { + if (NROW(dvobject[[name]]) > 0) { + message(paste("Subsetting", name, "...")) + filtered_subtable <- dvobject[[name]] %>% + dplyr::filter(.data$drugbank_id %in% drug_ids) + if (NROW(filtered_subtable) > 0) { + new_dvobject[[name]] <- filtered_subtable + } + } + } + + # --- 3. Filter the drugs`references` list --- + if (!is.null(dvobject$references) && !is.null(dvobject$references$drugs)) { + message("Subsetting drugs `references` list...") + new_dvobject$references$drugs <- list() + for (name in names(dvobject$references$drugs)) { + sub_table <- dvobject$references$drugs[[name]] + if (is.data.frame(sub_table) && "drugbank_id" %in% names(sub_table)) { + filtered_subtable <- sub_table %>% + dplyr::filter(.data$drugbank_id %in% drug_ids) + if (NROW(filtered_subtable) > 0) { + new_dvobject$references$drugs[[name]] <- filtered_subtable + } + } + } + } + + # --- 4. Filter the complex, multi-level `cett` List --- + if (!is.null(dvobject$cett)) { + message("Subsetting complex `cett` list...") + new_dvobject$cett <- list() + + # Apply the helper to each component within cett + for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { + component <- subset_cett_component( + component = dvobject$cett[[cett_name]], + component_name = cett_name, + drug_ids = drug_ids) + + if (length(component) > 0) { + new_dvobject$cett[[cett_name]] <- component + } + } + } + + # --- 5. Filter the CETT`references` list --- + if (!is.null(dvobject$references)) { + for (cett_name in c("carriers", "enzymes", "targets", "transporters")) { + if ((length(dvobject$references[[cett_name]]) > 0) && + (length(new_dvobject$cett[[cett_name]]) > 0)) { + message("Subsetting ", cett_name ," references list...") + cett_references <- list() + # The name of the intermediate ID, e.g., "carrier_id", "target_id" + intermediate_id_col <- paste0(sub("s$", "", cett_name), "_id") + + for (name in names(dvobject$references[[cett_name]])) { + sub_table <- dvobject$references[[cett_name]][[name]] + if (is.data.frame(sub_table) && (intermediate_id_col %in% names(sub_table))) { + filtered_subtable <- sub_table %>% + dplyr::filter(.data[[intermediate_id_col]] %in% new_dvobject$cett[[cett_name]][["general_information"]][[intermediate_id_col]]) + if (NROW(filtered_subtable) > 0) { + new_dvobject$references[[cett_name]][[name]] <- filtered_subtable + } + } + } + } + } + } + + attr(new_dvobject, "original_db_info") <- attr(dvobject, "original_db_info") + class(new_dvobject) <- "dvobject" + + # --- Final Step: Preserve original object's attributes --- + #attributes(new_dvobject) <- attributes(dvobject) + message("Subsetting complete.") + } + + new_dvobject +} + + +#' Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) +#' +#' Intelligently filters an OnSIDES dvobject by cascading filters through the +#' relational tables, ensuring the final subset is self-consistent. +#' +#' @param dvobject A dvobject from `parseOnSIDES()`. +#' @param ingredient_ids A character vector of RxNorm CUIs (ingredients) to keep. +#' +#' @export +#' @importFrom dplyr filter pull .data +#' +#' @return A new, smaller dvobject with the same structure. +#' @family utility +subset_onsides_dvobject <- function(dvobject, ingredient_ids) { + new_dvobject <- NULL + + if ((length(ingredient_ids) == 0) || (sum(nchar(ingredient_ids)) == 0)) { + warning("`ingredient_ids` is empty. Returning NULL") + } else { + new_dvobject <- init_dvobject() + + # --- 1. Get the cascading set of keys --- + message("Subsetting OnSIDES: Identifying all related keys...") + # Find all products containing our target ingredients + relevant_product_ids <- dvobject$vocab_rxnorm_ingredient_to_product %>% + dplyr::filter(.data$ingredient_id %in% ingredient_ids) %>% + dplyr::pull(.data$product_id) %>% + unique() + + # Find all labels associated with those products + relevant_label_ids <- dvobject$product_to_rxnorm %>% + dplyr::filter(.data$rxnorm_product_id %in% relevant_product_ids) %>% + dplyr::pull(.data$label_id) %>% + unique() + + # --- 2. Filter the main data tables --- + message("Filtering main OnSIDES data tables...") + product_adverse_effect <- dvobject$product_adverse_effect %>% + dplyr::filter(.data$product_label_id %in% relevant_label_ids) + + if (NROW(product_adverse_effect) > 0) { + new_dvobject$product_adverse_effect <- product_adverse_effect + } + + if ("high_confidence" %in% names(dvobject)) { + high_confidence <- dvobject$high_confidence %>% + dplyr::filter(.data$ingredient_id %in% ingredient_ids) + + if (NROW(high_confidence) > 0) { + new_dvobject$high_confidence <- high_confidence + } + } + + # --- 3. Filter the "bridge" and vocabulary tables to keep the subset lean --- + message("Filtering vocabulary and mapping tables...") + product_label <- dvobject$product_label %>% + dplyr::filter(.data$label_id %in% relevant_label_ids) + + if (NROW(product_label) > 0) { + new_dvobject$product_label <- product_label + } + + product_to_rxnorm <- dvobject$product_to_rxnorm %>% + dplyr::filter(.data$label_id %in% relevant_label_ids) + + if (NROW(product_to_rxnorm) > 0) { + new_dvobject$product_to_rxnorm <- product_to_rxnorm + } + + vocab_rxnorm_ingredient_to_product <- dvobject$vocab_rxnorm_ingredient_to_product %>% + dplyr::filter(.data$ingredient_id %in% ingredient_ids) + + if (NROW(vocab_rxnorm_ingredient_to_product) > 0) { + new_dvobject$vocab_rxnorm_ingredient_to_product <- vocab_rxnorm_ingredient_to_product + } + + # Find all MedDRA effects that are actually present in our subset + relevant_meddra_ids <- new_dvobject$product_adverse_effect$effect_meddra_id %>% unique() + + vocab_meddra_adverse_effect <- dvobject$vocab_meddra_adverse_effect %>% + dplyr::filter(.data$meddra_id %in% relevant_meddra_ids) + + if (NROW(vocab_meddra_adverse_effect) > 0) { + new_dvobject$vocab_meddra_adverse_effect <- vocab_meddra_adverse_effect + } + + vocab_rxnorm_ingredient <- dvobject$vocab_rxnorm_ingredient %>% + dplyr::filter(.data$rxnorm_id %in% ingredient_ids) + + if (NROW(vocab_rxnorm_ingredient) > 0) { + new_dvobject$vocab_rxnorm_ingredient <- vocab_rxnorm_ingredient + } + + vocab_rxnorm_product <- dvobject$vocab_rxnorm_product %>% + dplyr::filter(.data$rxnorm_id %in% relevant_product_ids) + + if (NROW(vocab_rxnorm_product) > 0) { + new_dvobject$vocab_rxnorm_product <- vocab_rxnorm_product + } + + # Preserve attributes and return + attr(new_dvobject, "original_db_info") <- attr(dvobject, "original_db_info") + class(new_dvobject) <- "dvobject" + } + + new_dvobject +} diff --git a/README.Rmd b/README.Rmd index 4cde3902..59eb4fb7 100644 --- a/README.Rmd +++ b/README.Rmd @@ -21,28 +21,33 @@ library(ggplot2) [![Project Status: Active – The project has reached a stable, usable state and is being actively developed.](https://www.repostatus.org/badges/latest/active.svg)](https://www.repostatus.org/#active) [![Lifecycle: stable](https://img.shields.io/badge/lifecycle-stable-brightgreen.svg)](https://lifecycle.r-lib.org/articles/stages.html) [![metacran downloads](https://cranlogs.r-pkg.org/badges/grand-total/dbparser)](https://cran.r-project.org/package=dbparser) -[![](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) +[![Rdoc Documentation](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) [![CII Best Practices](https://bestpractices.coreinfrastructure.org/projects/3311/badge)](https://bestpractices.coreinfrastructure.org/projects/3311) -[![](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) +[![rOpenSci Peer-Reviewed](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) ## Overview Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only -two databases together such as [DrugBank](https://go.drugbank.com/) and [KEGG](https://www.genome.jp/kegg/). +two databases together such as [DrugBank](https://go.drugbank.com/), [OnSIDES](https://onsidesdb.org/), and [TWOSIDES](https://tatonettilab.org/resources/nsides/). -Hence, `dbparser` package aims to parse different public drugs databases as [DrugBank](https://go.drugbank.com/) or [KEGG](https://www.genome.jp/kegg/) into +Hence, `dbparser` package aims to parse different public drugs databases into a single and unified format R object called `dvobject` (stands for drugverse object). +With recent updates, `dbparser` has evolved into an **integration engine**, allowing you to merge mechanistic data (DrugBank) with real-world phenotypic data (OnSIDES) and drug-drug interaction risks (TWOSIDES). + That should help in: - working with single data object and not multiple databases in different formats, - using R analysis capabilities easily on drugs data, - ease of transferring data between researchers after performing required data -analysis or `dvobject` and storing results in the same object in a very easy manner +analysis or `dvobject` and storing results in the same object in a very easy manner. ### dvobject Structure `dvobject` introduces a unified and compressed format of drugs data. -It is an R list object that contains one or more of the following sub-lists: +It is an R list object. + +**For a single database (e.g., DrugBank):** +It contains one or more of the following sub-lists: - **drugs**: list of data.frames that contain drugs information (i.e. synonyms, classifications, ...) and it is the only mandatory list - **salts**: data.frame contains drugs salts information @@ -50,10 +55,19 @@ It is an R list object that contains one or more of the following sub-lists: - **references**: data.frame of articles, links and textbooks about drugs or CETT data - **cett**: list of data.frames contain targets, enzymes, carriers and transporters information +**For a merged database (Integrated Pharmacovigilance):** +When databases are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, the `dvobject` becomes a nested structure containing: + +- **drugbank**: The mechanistic hub. +- **onsides**: The side-effect data (from FDA labels). +- **twosides**: The drug-drug interaction data. +- **integrated_data**: Enriched tables that bridge the databases (e.g., linking DrugBank IDs to OnSIDES adverse events). +- **metadata**: Detailed provenance for all contained datasets. + ## Drug Databases Parsers are available for the following databases (it is in progress list) -### DrugBank +### 1. DrugBank [DrugBank](https://go.drugbank.com/) database is a comprehensive, freely accessible, online database containing information on drugs and drug @@ -72,7 +86,7 @@ The `dbparser` package parses the DrugBank XML database into `R` tibbles that ca If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the `dbdataset` -[package](https://interstellar-consultation-services.github.io/dbdataset/), which contains +[package](https://interstellar-egypt.github.io/dbdataset/), which contains the DrugBank database already parsed into `dvobject`. Note that this is a large package that exceeds the limit set by CRAN. It is only available on GitHub. @@ -81,6 +95,42 @@ successfully. If you find errors with these versions or any other version please submit an issue [here](https://github.com/ropensci/dbparser/issues). +### 2. OnSIDES (The Phenotype) +[OnSIDES](https://onsidesdb.org/) provides adverse drug events extracted from thousands of FDA drug labels using machine learning. +* **Parser:** `parseOnSIDES()` +* **Input:** Directory containing OnSIDES CSV files. + +### 3. TWOSIDES (Polypharmacy) +[TWOSIDES](https://tatonettilab.org/resources/nsides/) provides data on drug-drug interactions and the adverse events that arise when two drugs are taken together. +* **Parser:** `parseTWOSIDES()` +* **Input:** The `TWOSIDES.csv.gz` file. + +## Quick Start: Integration Pipeline + +The power of `dbparser` lies in its ability to chain parsers and mergers together. Here is how you can build a complete pharmacovigilance dataset: + +```r +library(dbparser) +library(dplyr) + +# 1. Parse the raw databases +drugbank_db <- parseDrugBank("data/drugbank.xml") +onsides_db <- parseOnSIDES("data/onsides/") +twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz") + +# 2. Build the Integrated Knowledge Graph +# DrugBank serves as the hub. We chain the merges. +final_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# 3. Analyze Results +# Example: Accessing the enriched drug-drug interaction table +head(final_db$integrated_data$drug_drug_interactions) +``` + +For a detailed case study, please refer to the [Integrated Pharmacovigilance Vignette](https://docs.ropensci.org/dbparser/articles/drugbank_nside.html). + ## Installation You can install the released version of dbparser from diff --git a/README.md b/README.md index 36f84eef..85d24fd5 100644 --- a/README.md +++ b/README.md @@ -12,23 +12,29 @@ developed.](https://www.repostatus.org/badges/latest/active.svg)](https://www.re stable](https://img.shields.io/badge/lifecycle-stable-brightgreen.svg)](https://lifecycle.r-lib.org/articles/stages.html) [![metacran downloads](https://cranlogs.r-pkg.org/badges/grand-total/dbparser)](https://cran.r-project.org/package=dbparser) -[![](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) +[![Rdoc +Documentation](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) [![CII Best Practices](https://bestpractices.coreinfrastructure.org/projects/3311/badge)](https://bestpractices.coreinfrastructure.org/projects/3311) -[![](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) +[![rOpenSci +Peer-Reviewed](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) ## Overview Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only two databases together such as -[DrugBank](https://go.drugbank.com/) and -[KEGG](https://www.genome.jp/kegg/). +[DrugBank](https://go.drugbank.com/), [OnSIDES](https://onsidesdb.org/), +and [TWOSIDES](https://tatonettilab.org/resources/nsides/). Hence, `dbparser` package aims to parse different public drugs databases -as [DrugBank](https://go.drugbank.com/) or -[KEGG](https://www.genome.jp/kegg/) into single and unified format R -object called `dvobject` (stands for drugverse object). +into a single and unified format R object called `dvobject` (stands for +drugverse object). + +With recent updates, `dbparser` has evolved into an **integration +engine**, allowing you to merge mechanistic data (DrugBank) with +real-world phenotypic data (OnSIDES) and drug-drug interaction risks +(TWOSIDES). That should help in: @@ -37,13 +43,15 @@ That should help in: - using R analysis capabilities easily on drugs data, - ease of transferring data between researchers after performing required data analysis or `dvobject` and storing results in the same - object in a very easy manner + object in a very easy manner. ### dvobject Structure `dvobject` introduces a unified and compressed format of drugs data. It -is an R list object that contains one or more of the following -sub-lists: +is an R list object. + +**For a single database (e.g., DrugBank):** It contains one or more of +the following sub-lists: - **drugs**: list of data.frames that contain drugs information (i.e. synonyms, classifications, …) and it is the only mandatory list @@ -55,12 +63,23 @@ sub-lists: - **cett**: list of data.frames contain targets, enzymes, carriers and transporters information +**For a merged database (Integrated Pharmacovigilance):** When databases +are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, +the `dvobject` becomes a nested structure containing: + +- **drugbank**: The mechanistic hub. +- **onsides**: The side-effect data (from FDA labels). +- **twosides**: The drug-drug interaction data. +- **integrated_data**: Enriched tables that bridge the databases (e.g., + linking DrugBank IDs to OnSIDES adverse events). +- **metadata**: Detailed provenance for all contained datasets. + ## Drug Databases Parsers are available for the following databases (it is in progress list) -### DrugBank +### 1. DrugBank [DrugBank](https://go.drugbank.com/) database is a comprehensive, freely accessible, online database containing information on drugs and drug @@ -83,16 +102,59 @@ more details. If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the `dbdataset` -[package](https://interstellar-consultation-services.github.io/dbdataset/), -which contains the DrugBank database already parsed into `dvobject`. -Note that this is a large package that exceeds the limit set by CRAN. It -is only available on GitHub. +[package](https://interstellar-egypt.github.io/dbdataset/), which +contains the DrugBank database already parsed into `dvobject`. Note that +this is a large package that exceeds the limit set by CRAN. It is only +available on GitHub. `dbparser` is tested against DrugBank versions *5.1.0* through *5.1.12* successfully. If you find errors with these versions or any other version please submit an issue [here](https://github.com/ropensci/dbparser/issues). +### 2. OnSIDES (The Phenotype) + +[OnSIDES](https://onsidesdb.org/) provides adverse drug events extracted +from thousands of FDA drug labels using machine learning. \* **Parser:** +`parseOnSIDES()` \* **Input:** Directory containing OnSIDES CSV files. + +### 3. TWOSIDES (Polypharmacy) + +[TWOSIDES](https://tatonettilab.org/resources/nsides/) provides data on +drug-drug interactions and the adverse events that arise when two drugs +are taken together. \* **Parser:** `parseTWOSIDES()` \* **Input:** The +`TWOSIDES.csv.gz` file. + +## Quick Start: Integration Pipeline + +The power of `dbparser` lies in its ability to chain parsers and mergers +together. Here is how you can build a complete pharmacovigilance +dataset: + +``` r +library(dbparser) +library(dplyr) + +# 1. Parse the raw databases +drugbank_db <- parseDrugBank("data/drugbank.xml") +onsides_db <- parseOnSIDES("data/onsides/") +twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz") + +# 2. Build the Integrated Knowledge Graph +# DrugBank serves as the hub. We chain the merges. +final_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# 3. Analyze Results +# Example: Accessing the enriched drug-drug interaction table +head(final_db$integrated_data$drug_drug_interactions) +``` + +For a detailed case study, please refer to the [Integrated +Pharmacovigilance +Vignette](https://docs.ropensci.org/dbparser/articles/drugbank_nside.html). + ## Installation You can install the released version of dbparser from @@ -134,7 +196,7 @@ citation("dbparser") #> To cite dbparser in publications use: #> #> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. -#> R package version 2.0.3. +#> R package version 2.2.0. #> #> A BibTeX entry for LaTeX users is #> @@ -142,7 +204,7 @@ citation("dbparser") #> title = {DrugBank Database XML Parser}, #> author = {Mohammed Ali and Ali Ezzat}, #> organization = {Interstellar for Consultinc inc.}, -#> note = {R package version 2.0.3}, +#> note = {R package version 2.2.0}, #> url = {https://CRAN.R-project.org/package=dbparser}, #> } ``` diff --git a/_pkgdown.yml b/_pkgdown.yml index 7cbf2dcc..d177f4da 100644 --- a/_pkgdown.yml +++ b/_pkgdown.yml @@ -1,17 +1,19 @@ +template: + bootstrap: 5 + bootswatch: flatly + +url: https://docs.ropensci.org/dbparser + navbar: + bg: primary structure: - left: - - home - - intro - - reference - - articles - - tutorials - - news - right: github + left: [intro, reference, articles, news] + right: [search, github] components: home: icon: fas fa-home fa-lg href: index.html + aria-label: "Home" reference: text: Reference href: reference/index.html @@ -21,6 +23,10 @@ navbar: news: text: Changelog href: news/index.html + github: + icon: fab fa-github + href: https://github.com/ropensci/dbparser + aria-label: "GitHub" reference: - title: "Drugs Databases Parser" @@ -31,6 +37,10 @@ reference: desc: "Different functions to handle dvobject" contents: - has_concept("utility") +- title: "Merge functions" + desc: "Different functions to merge different types of dvobjects" + contents: + - has_concept("mergers") authors: Mohammed Ali: diff --git a/cran-comments.md b/cran-comments.md index a7291b70..bcc7a9ad 100644 --- a/cran-comments.md +++ b/cran-comments.md @@ -1,22 +1,16 @@ ## Test environments -### local Windows 10(x86_64-w64-mingw32), 4.3.2 +### local Windows 11, 4.5.1 0 errors | 0 warnings | 0 note ### Windows Server 2022, R-devel, 64 bit -0 errors | 0 warnings | 1 note - -``` Found the following files/directories: - 'lastMiKTeXException'``` +0 errors | 0 warnings | 0 note ### Ubuntu Linux 20.04.1 LTS, R-release, GCC -0 errors | 0 warnings | 0 not +0 errors | 0 warnings | 0 note ### Fedora Linux, R-devel, clang, gfortran -0 errors | 0 warnings | 1 note - -```* checking HTML version of manual ... NOTE -Skipping checking HTML validation: no command 'tidy' found``` +0 errors | 0 warnings | 0 note ### win-builder (R version 4.4.0 RC (2024-04-16 r86451 ucrt)) 0 errors | 0 warnings | 0 note @@ -27,3 +21,10 @@ We checked 0 reverse dependencies, comparing R CMD check results across CRAN and * We saw 0 new problems * We failed to check 0 packages + +### RHub + +rhub::rc_submit() # multiple environments are used for testing + +### URL checks +- DrugBank URLs (403): Valid URLs, site blocks automated requests diff --git a/docs/404.html b/docs/404.html index f0b3f1a5..4e29c6ab 100644 --- a/docs/404.html +++ b/docs/404.html @@ -4,116 +4,85 @@ - + Page not found (404) • dbparser - - - - - - - - - - - - - - + + + + + + + + + + + - - - -
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Page not found (404)

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Page not found (404)

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Content not found. Please use links in the navbar. -
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- -
- - + diff --git a/docs/404.md b/docs/404.md new file mode 100644 index 00000000..5107f896 --- /dev/null +++ b/docs/404.md @@ -0,0 +1,3 @@ +Content not found. Please use links in the navbar. + +# Page not found (404) diff --git a/docs/CODE_OF_CONDUCT.html b/docs/CODE_OF_CONDUCT.html index fc4fcc61..3efa0b5f 100644 --- a/docs/CODE_OF_CONDUCT.html +++ b/docs/CODE_OF_CONDUCT.html @@ -1,58 +1,40 @@ -Contributor Covenant Code of Conduct • dbparser - - -
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Contributor Covenant Code of Conduct

+ + + +
+
+
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+

Contributor Covenant Code of Conduct

+ Source: CODE_OF_CONDUCT.md
@@ -97,30 +79,23 @@

Attribution

- +
-
- - diff --git a/docs/CODE_OF_CONDUCT.md b/docs/CODE_OF_CONDUCT.md new file mode 100644 index 00000000..26d30184 --- /dev/null +++ b/docs/CODE_OF_CONDUCT.md @@ -0,0 +1,81 @@ +# Contributor Covenant Code of Conduct + +## Our Pledge + +In the interest of fostering an open and welcoming environment, we as +contributors and maintainers pledge to making participation in our +project and our community a harassment-free experience for everyone, +regardless of age, body size, disability, ethnicity, sex +characteristics, gender identity and expression, level of experience, +education, socio-economic status, nationality, personal appearance, +race, religion, or sexual identity and orientation. + +## Our Standards + +Examples of behavior that contributes to creating a positive environment +include: + +- Using welcoming and inclusive language +- Being respectful of differing viewpoints and experiences +- Gracefully accepting constructive criticism +- Focusing on what is best for the community +- Showing empathy towards other community members + +Examples of unacceptable behavior by participants include: + +- The use of sexualized language or imagery and unwelcome sexual + attention or advances +- Trolling, insulting/derogatory comments, and personal or political + attacks +- Public or private harassment +- Publishing others’ private information, such as a physical or + electronic address, without explicit permission +- Other conduct which could reasonably be considered inappropriate in a + professional setting + +## Our Responsibilities + +Project maintainers are responsible for clarifying the standards of +acceptable behavior and are expected to take appropriate and fair +corrective action in response to any instances of unacceptable behavior. + +Project maintainers have the right and responsibility to remove, edit, +or reject comments, commits, code, wiki edits, issues, and other +contributions that are not aligned to this Code of Conduct, or to ban +temporarily or permanently any contributor for other behaviors that they +deem inappropriate, threatening, offensive, or harmful. + +## Scope + +This Code of Conduct applies both within project spaces and in public +spaces when an individual is representing the project or its community. +Examples of representing a project or community include using an +official project e-mail address, posting via an official social media +account, or acting as an appointed representative at an online or +offline event. Representation of a project may be further defined and +clarified by project maintainers. + +## Enforcement + +Instances of abusive, harassing, or otherwise unacceptable behavior may +be reported by contacting the project team at +. All complaints will be reviewed and +investigated and will result in a response that is deemed necessary and +appropriate to the circumstances. The project team is obligated to +maintain confidentiality with regard to the reporter of an incident. +Further details of specific enforcement policies may be posted +separately. + +Project maintainers who do not follow or enforce the Code of Conduct in +good faith may face temporary or permanent repercussions as determined +by other members of the project’s leadership. + +## Attribution + +This Code of Conduct is adapted from the [Contributor +Covenant](https://www.contributor-covenant.org), version 1.4, available +at + + +For answers to common questions about this code of conduct, see + diff --git a/docs/CONTRIBUTING.html b/docs/CONTRIBUTING.html index a5deca60..e5d084b6 100644 --- a/docs/CONTRIBUTING.html +++ b/docs/CONTRIBUTING.html @@ -1,58 +1,40 @@ -Contributing to dbparser • dbparser - - -
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Contributing to dbparser

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Contributing to dbparser

+ Source: CONTRIBUTING.md
@@ -68,35 +50,35 @@

Code of conductHow you can contribute

There are several ways you can contribute to this project. If you want to know more about why and how to contribute to open source projects like this one, see this Open Source Guide.

-

Share the love ❤️

+

Share the love ❤️

Think dbparser is useful? Let others discover it, by telling them in person, via Twitter or a blog post.

-

Using dbparser for a paper you are writing? Consider citing it.

+

Using dbparser for a paper you are writing? Consider citing it.

-

Ask a question ⁉️

-

Using our_package and got stuck? Browse the documentation to see if you can find a solution. Still stuck? Post your question as an issue on GitHub. While we cannot offer user support, we’ll try to do our best to address it, as questions often lead to better documentation or the discovery of bugs.

+

Ask a question ⁉️

+

Using our_package and got stuck? Browse the documentation to see if you can find a solution. Still stuck? Post your question as an issue on GitHub. While we cannot offer user support, we’ll try to do our best to address it, as questions often lead to better documentation or the discovery of bugs.

Want to ask a question in private? Contact the package maintainer by email.

-

Propose an idea 💡

-

Have an idea for a new our_package feature? Take a look at the documentation and issue list to see if it isn’t included or suggested yet. If not, suggest your idea as an issue on GitHub. While we can’t promise to implement your idea, it helps to:

+

Propose an idea 💡

+

Have an idea for a new our_package feature? Take a look at the documentation and issue list to see if it isn’t included or suggested yet. If not, suggest your idea as an issue on GitHub. While we can’t promise to implement your idea, it helps to:

  • Explain in detail how it would work.
  • Keep the scope as narrow as possible.

See below if you want to contribute code for your idea as well.

-

Report a bug 🐛

+

Report a bug 🐛

Using our_package and discovered a bug? That’s annoying! Don’t let others have the same experience and report it as an issue on GitHub so we can fix it. A good bug report makes it easier for us to do so, so please include:

  • Your operating system name and version (e.g. Mac OS 10.13.6).
  • Any details about your local setup that might be helpful in troubleshooting.
  • Detailed steps to reproduce the bug.
-

Improve the documentation 📖

+

Improve the documentation 📖

Noticed a typo on the website? Think a function could use a better example? Good documentation makes all the difference, so your help to improve it is very welcome!

The website

-

This website is generated with pkgdown. That means we don’t have to write any html: content is pulled together from documentation in the code, vignettes, Markdown files, the package DESCRIPTION and _pkgdown.yml settings. If you know your way around pkgdown, you can propose a file change to improve documentation. If not, report an issue and we can point you in the right direction.

+

This website is generated with pkgdown. That means we don’t have to write any html: content is pulled together from documentation in the code, vignettes, Markdown files, the package DESCRIPTION and _pkgdown.yml settings. If you know your way around pkgdown, you can propose a file change to improve documentation. If not, report an issue and we can point you in the right direction.

Function documentation

@@ -108,7 +90,7 @@

Function documentation

-

Contribute code 📝

+

Contribute code 📝

Care to fix bugs or implement new functionality for our_package? Awesome! 👏 Have a look at the issue list and leave a comment on the things you want to work on. See also the development guidelines below.

@@ -129,30 +111,23 @@

Development guidelines

-
+
- +
-
- - diff --git a/docs/CONTRIBUTING.md b/docs/CONTRIBUTING.md new file mode 100644 index 00000000..55b2558f --- /dev/null +++ b/docs/CONTRIBUTING.md @@ -0,0 +1,134 @@ +# Contributing to dbparser + +First of all, thanks for considering contributing to dbparser! 👍 It’s +people like you that make it rewarding for us - the project +maintainers - to work on dbparser. 😊 + +dbparser is an open source project, maintained by people who care. We +are not directly funded to do so. + +## Code of conduct + +Please note that this project is released with a [Contributor Code of +Conduct](https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.md). By +participating in this project you agree to abide by its terms. + +## How you can contribute + +There are several ways you can contribute to this project. If you want +to know more about why and how to contribute to open source projects +like this one, see this [Open Source +Guide](https://opensource.guide/how-to-contribute/). + +### Share the love ❤️ + +Think **dbparser** is useful? Let others discover it, by telling them in +person, via Twitter or a blog post. + +Using **dbparser** for a paper you are writing? Consider [citing +it](https://docs.ropensci.org/dbparser/authors.html). + +### Ask a question ⁉️ + +Using our_package and got stuck? Browse the +[documentation](https://docs.ropensci.org/dbparser/) to see if you can +find a solution. Still stuck? Post your question as an [issue on +GitHub](https://github.com/ropensci/dbparser/issues/new). While we +cannot offer user support, we’ll try to do our best to address it, as +questions often lead to better documentation or the discovery of bugs. + +Want to ask a question in private? Contact the package maintainer by +[email](https://docs.ropensci.org/dbparser/mohammed.ali@edu.dsti.institute). + +### Propose an idea 💡 + +Have an idea for a new our_package feature? Take a look at the +[documentation](https://docs.ropensci.org/dbparser/) and [issue +list](https://github.com/ropensci/dbparser/issues) to see if it isn’t +included or suggested yet. If not, suggest your idea as an [issue on +GitHub](https://github.com/ropensci/dbparser/issues/new). While we can’t +promise to implement your idea, it helps to: + +- Explain in detail how it would work. +- Keep the scope as narrow as possible. + +See below if you want to contribute code for your idea as well. + +### Report a bug 🐛 + +Using our_package and discovered a bug? That’s annoying! Don’t let +others have the same experience and report it as an [issue on +GitHub](https://github.com/ropensci/dbparser/issues/new) so we can fix +it. A good bug report makes it easier for us to do so, so please +include: + +- Your operating system name and version (e.g. Mac OS 10.13.6). +- Any details about your local setup that might be helpful in + troubleshooting. +- Detailed steps to reproduce the bug. + +### Improve the documentation 📖 + +Noticed a typo on the website? Think a function could use a better +example? Good documentation makes all the difference, so your help to +improve it is very welcome! + +#### The website + +[This website](https://docs.ropensci.org/dbparser/) is generated with +[`pkgdown`](http://pkgdown.r-lib.org/). That means we don’t have to +write any html: content is pulled together from documentation in the +code, vignettes, +[Markdown](https://guides.github.com/features/mastering-markdown/) +files, the package `DESCRIPTION` and `_pkgdown.yml` settings. If you +know your way around `pkgdown`, you can [propose a file +change](https://help.github.com/articles/editing-files-in-another-user-s-repository/) +to improve documentation. If not, [report an +issue](https://github.com/ropensci/dbparser/issues/new) and we can point +you in the right direction. + +#### Function documentation + +Functions are described as comments near their code and translated to +documentation using [`roxygen2`](https://klutometis.github.io/roxygen/). +If you want to improve a function description: + +1. Go to `R/` directory in the [code + repository](https://github.com/ropensci/dbparser). +2. Look for the file with the name of the function. +3. [Propose a file + change](https://help.github.com/articles/editing-files-in-another-user-s-repository/) + to update the function documentation in the roxygen comments + (starting with `#'`). + +### Contribute code 📝 + +Care to fix bugs or implement new functionality for our_package? +Awesome! 👏 Have a look at the [issue +list](https://github.com/ropensci/dbparser/issues) and leave a comment +on the things you want to work on. See also the development guidelines +below. + +## Development guidelines + +We try to follow the [GitHub +flow](https://guides.github.com/introduction/flow/) for development. + +1. Fork [this repo](https://github.com/ropensci/dbparser) and clone it + to your computer. To learn more about this process, see [this + guide](https://guides.github.com/activities/forking/). +2. If you have forked and cloned the project before and it has been a + while since you worked on it, [pull changes from the original + repo](https://help.github.com/articles/merging-an-upstream-repository-into-your-fork/) + to your clone by using `git pull upstream master`. +3. Open the RStudio project file (`.Rproj`). +4. Make your changes: + - Write your code. + - Test your code (bonus points for adding unit tests). + - Document your code (see function documentation above). + - Check your code with + [`devtools::check()`](https://devtools.r-lib.org/reference/check.html) + and aim for 0 errors and warnings. +5. Commit and push your changes. +6. Submit a [pull + request](https://guides.github.com/activities/forking/#making-a-pull-request). diff --git a/docs/LICENSE-text.html b/docs/LICENSE-text.html index 3559559c..7c156a8c 100644 --- a/docs/LICENSE-text.html +++ b/docs/LICENSE-text.html @@ -1,88 +1,62 @@ -License • dbparser - - -
-
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License

YEAR: 2018
 COPYRIGHT HOLDER: Mohammed Ali, Ali Ezzat
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- +
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- - diff --git a/docs/LICENSE-text.md b/docs/LICENSE-text.md new file mode 100644 index 00000000..0415602f --- /dev/null +++ b/docs/LICENSE-text.md @@ -0,0 +1,4 @@ +# License + + YEAR: 2018 + COPYRIGHT HOLDER: Mohammed Ali, Ali Ezzat diff --git a/docs/articles/dbparser.html b/docs/articles/dbparser.html index d970bc92..237696f0 100644 --- a/docs/articles/dbparser.html +++ b/docs/articles/dbparser.html @@ -4,94 +4,72 @@ - -DrugBank Database XML Parser • dbparser - - - - - - - - - - - - - - - + +Unlocking DrugBank: Parsing and Visualizing Mechanistic Data • dbparser + + + + + + + + + + - - + + Skip to contents -
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DrugBank Database XML Parser

+ +
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+

Unlocking DrugBank: Parsing and Visualizing Mechanistic Data

Mohammed Ali

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2024-04-20

+

2026-01-08

Source: vignettes/dbparser.Rmd - - +
dbparser.Rmd
@@ -99,154 +77,171 @@

2024-04-20

Introduction

-

The main purpose of the dbparser package is to parse the -DrugBank database which is -downloadable in XML format from this link. The parsed -data can then be explored and analyzed as desired by the user. In this -tutorial, we will see how to use dbparser along with -dplyr and ggplot2 along with other libraries -to do simple drug analysis

+

The DrugBank database is the global gold standard +for drug information, containing rich data on chemical structures, +pharmacology, and molecular targets. However, the raw data is provided +as a massive, complex XML file that is difficult to use in statistical +analysis.

+

dbparser solves this problem. It transforms that complex +XML into a Drugverse Object (dvobject)—a +structured collection of R data frames ready for analysis.

+

In this tutorial, we will demonstrate how to:

+
    +
  1. Parse the database.
    2. +
  2. Explore the data structure.
    3. +
  3. Visualize key insights using dplyr and +canvasXpress.
    4. +
-

Loading and Parsing the Data +

1. Loading Data

-

Before starting the code we are assuming the following:

-
    -
  • user already downloaded DrugBank xml database file based on -the Read Me -instructions or the above note,
    • -
  • user saved the downloaded database in working directory as -C:\.
    • -
  • user named the downloaded xml file -drugbank.xml.
    • -
-

Now we can loads the drugs info, -drug groups info and drug targets actions -info.

+
+

The Parsing Workflow +

+

In a real-world scenario, you would parse the full XML database +(downloaded from DrugBank) using +parseDrugBank().

-## load dbparser package
-suppressPackageStartupMessages({
+library(dbparser)
+
+# Parse the full XML file (this creates a dvobject)
+# drugbank_db <- parseDrugBank("drugbank_full_database.xml")
+
+
+

Loading Sample Data +

+

For this vignette, we will load curated sample datasets included in +the package. These represent specific tables that would be found inside +the full dvobject.

+
+suppressPackageStartupMessages({
   library(tidyr)
   library(dplyr)
-  library(canvasXpress)
   library(tibble)
-  library(dbparser)
+  library(canvasXpress)
+  library(dbparser)
 })
 
-
-## load drugs data
+# Load sample tables representing parts of the parsed dvobject
 drugs <- readRDS(system.file("drugs.RDS", package = "dbparser"))
-
-## load drug groups data
 drug_groups <- readRDS(system.file("drug_groups.RDS", package = "dbparser"))
-
-## load drug targets actions data
 drug_targets_actions <- readRDS(system.file("targets_actions.RDS", package = "dbparser"))
+
-

Exploring the data +

2. Analysis: The Drug Landscape

-

Following is an example involving a quick look at a few aspects of -the parsed data. First we look at the proportions of -biotech and small-molecule drugs in the -data.

-
-## view proportions of the different drug types (biotech vs. small molecule)
+
What does the universe of approved drugs look like? Let’s analyze the
+composition of the database by drug type (Small Molecule
+vs. Biotech).

+
+# Prepare data: Count drugs by type
 type_stat <- drugs %>% 
-  select(type) %>% 
   group_by(type) %>% 
-  summarise(count = n()) %>% 
+  summarise(Count = n()) %>% 
+  arrange(desc(Count)) %>% 
   column_to_rownames("type")
 
+# Visualize
 canvasXpress(
   data             = type_stat,
-  graphOrientation = "vertical",
   graphType        = "Bar",
+  title            = "Composition of DrugBank: Drug Types",
   showSampleNames  = FALSE,
-  title            ="Drugs Type Distribution",
-  xAxisTitle       = "Count"
+  legendPosition   = "right"
 )

-

-
Below, we view the different drug_groups in the data and
-how prevalent they are.

-
-## view proportions of the different drug types for each drug group
-type_stat <- drugs %>% 
-  full_join(drug_groups, by = c("drugbank_id")) %>% 
-  select(type, group) %>% 
+

+
+

+

+
3. Analysis: Approval Status
+

+
Drugs are categorized into groups such as “approved”,
+“investigational”, or “experimental”. How does the complexity (Biotech
+vs. Small Molecule) differ across these groups?

+
+# Prepare data: Cross-tabulate Type vs Group
+group_stat <- drugs %>% 
+  full_join(drug_groups, by = "drugbank_id") %>% 
   group_by(type, group) %>% 
-  summarise(count = n()) %>% 
-  pivot_wider(names_from = group, values_from = count) %>% 
+  summarise(count = n(), .groups = 'drop') %>% 
+  pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% 
   column_to_rownames("type")
-#> `summarise()` has grouped output by 'type'. You can override using the
-#> `.groups` argument.
 
+# Visualize with a Stacked Bar Chart
 canvasXpress(
-  data           = type_stat,
+  data           = group_stat,
   graphType      = "Stacked",
-  legendColumns  = 2,
+  graphOrientation = "horizontal",
+  title          = "Drug Types by Approval Status",
+  xAxisTitle     = "Number of Drugs",
   legendPosition = "bottom",
-  title          ="Drug Type Distribution per Drug Group",
-  xAxisTitle     = "Quantity",
-  xAxis2Show     = TRUE,
-  xAxisShow      = FALSE,
-  smpTitle      = "Drug Group")

-

-
Finally, we look at the drug_targets_actions to observe
-their proportions as well.

-
-## get counts of the different target actions in the data
-targetActionCounts <- 
-    drug_targets_actions %>% 
+  xAxis2Show     = FALSE
+)

+

+
+

+

+
4. Analysis: Molecular Mechanisms
+

+
One of DrugBank’s most valuable features is the detailed information
+on how drugs interact with their targets (Proteins, Enzymes, etc.). Are
+drugs mostly inhibitors, agonists, or antagonists?

+
+# Prepare data: Top 10 most common Mechanisms of Action
+targetActionCounts <- drug_targets_actions %>% 
     group_by(action) %>% 
-    summarise(count = n()) %>% 
-    arrange(desc(count)) %>% 
-    top_n(10) %>% 
+    summarise(Count = n()) %>% 
+    arrange(desc(Count)) %>% 
+    slice_head(n = 10) %>% 
     column_to_rownames("action")
-#> Selecting by count
 
-## get bar chart of the 10 most occurring target actions in the data
+# Visualize
 canvasXpress(
   data            = targetActionCounts,
   graphType       = "Bar",
-  legendColumns   = 2,
-  legendPosition  = "bottom",
-  title           = "Target Actions Distribution",
+  graphOrientation = "vertical",
+  colorBy         = "Count",
+  title           = "Top 10 Mechanisms of Action",
+  xAxisTitle      = "Number of Interactions",
   showSampleNames = FALSE,
-  xAxis2Show      = TRUE,
-  xAxisShow       = FALSE)

-

-
+  legendPosition  = "none"
+)
+
+
-
- - -
- - + diff --git a/docs/articles/dbparser.md b/docs/articles/dbparser.md new file mode 100644 index 00000000..2eb5fc4b --- /dev/null +++ b/docs/articles/dbparser.md @@ -0,0 +1,146 @@ +# Unlocking DrugBank: Parsing and Visualizing Mechanistic Data + +## Introduction + +The **DrugBank** database is the global gold standard for drug +information, containing rich data on chemical structures, pharmacology, +and molecular targets. However, the raw data is provided as a massive, +complex XML file that is difficult to use in statistical analysis. + +`dbparser` solves this problem. It transforms that complex XML into a +**Drugverse Object (`dvobject`)**—a structured collection of R data +frames ready for analysis. + +In this tutorial, we will demonstrate how to: + +1. Parse the database. +2. Explore the data structure. +3. Visualize key insights using `dplyr` and `canvasXpress`. + +## 1. Loading Data + +### The Parsing Workflow + +In a real-world scenario, you would parse the full XML database +(downloaded from [DrugBank](https://go.drugbank.com/releases/latest)) +using +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md). + +``` r +library(dbparser) + +# Parse the full XML file (this creates a dvobject) +# drugbank_db <- parseDrugBank("drugbank_full_database.xml") +``` + +### Loading Sample Data + +For this vignette, we will load curated sample datasets included in the +package. These represent specific tables that would be found inside the +full `dvobject`. + +``` r +suppressPackageStartupMessages({ + library(tidyr) + library(dplyr) + library(tibble) + library(canvasXpress) + library(dbparser) +}) + +# Load sample tables representing parts of the parsed dvobject +drugs <- readRDS(system.file("drugs.RDS", package = "dbparser")) +drug_groups <- readRDS(system.file("drug_groups.RDS", package = "dbparser")) +drug_targets_actions <- readRDS(system.file("targets_actions.RDS", package = "dbparser")) +``` + +## 2. Analysis: The Drug Landscape + +What does the universe of approved drugs look like? Let’s analyze the +composition of the database by drug type (Small Molecule vs. Biotech). + +``` r +# Prepare data: Count drugs by type +type_stat <- drugs %>% + group_by(type) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + column_to_rownames("type") + +# Visualize +canvasXpress( + data = type_stat, + graphType = "Bar", + title = "Composition of DrugBank: Drug Types", + showSampleNames = FALSE, + legendPosition = "right" +) +``` + +## 3. Analysis: Approval Status + +Drugs are categorized into groups such as “approved”, “investigational”, +or “experimental”. How does the complexity (Biotech vs. Small Molecule) +differ across these groups? + +``` r +# Prepare data: Cross-tabulate Type vs Group +group_stat <- drugs %>% + full_join(drug_groups, by = "drugbank_id") %>% + group_by(type, group) %>% + summarise(count = n(), .groups = 'drop') %>% + pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% + column_to_rownames("type") + +# Visualize with a Stacked Bar Chart +canvasXpress( + data = group_stat, + graphType = "Stacked", + graphOrientation = "horizontal", + title = "Drug Types by Approval Status", + xAxisTitle = "Number of Drugs", + legendPosition = "bottom", + xAxis2Show = FALSE +) +``` + +## 4. Analysis: Molecular Mechanisms + +One of DrugBank’s most valuable features is the detailed information on +how drugs interact with their targets (Proteins, Enzymes, etc.). Are +drugs mostly inhibitors, agonists, or antagonists? + +``` r +# Prepare data: Top 10 most common Mechanisms of Action +targetActionCounts <- drug_targets_actions %>% + group_by(action) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + slice_head(n = 10) %>% + column_to_rownames("action") + +# Visualize +canvasXpress( + data = targetActionCounts, + graphType = "Bar", + graphOrientation = "vertical", + colorBy = "Count", + title = "Top 10 Mechanisms of Action", + xAxisTitle = "Number of Interactions", + showSampleNames = FALSE, + legendPosition = "none" +) +``` + +## 5. Next Steps: Integrated Pharmacovigilance + +Now that you have mastered the mechanistic data in DrugBank, you can +combine it with real-world data! + +`dbparser` now supports **OnSIDES** (Adverse Events) and **TWOSIDES** +(Drug-Drug Interactions). + +Check out the **[Integrated Pharmacovigilance +Vignette](https://docs.ropensci.org/dbparser/articles/drugbank_nside.md)** +to learn how to merge these databases to perform polypharmacy risk +analysis. diff --git a/docs/articles/dbparser_2_2.html b/docs/articles/dbparser_2_2.html new file mode 100644 index 00000000..05cf523c --- /dev/null +++ b/docs/articles/dbparser_2_2.html @@ -0,0 +1,174 @@ + + + + + + + +Introducing dbparser 2.2.0 • dbparser + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

Introducing dbparser 2.2.0

+ + + Source: vignettes/dbparser_2_2.Rmd +
dbparser_2_2.Rmd
+
+ + + +

Data in computational pharmacology is often siloed. We have databases +that tell us what a drug is (DrugBank), databases that tell us +what side effects it causes (OnSIDES), and databases that tell +us how it interacts with other drugs (TWOSIDES).

+

Connecting these silos has historically been a painful process of +manual mapping and ad-hoc scripting. Today, we are releasing +dbparser 2.2.0 to solve this problem once and for all.

+
+

The “Hub and Spoke” Architecture +

+

Version 2.2.0 moves beyond simple XML parsing. We have re-engineered +the package around a “Hub and Spoke” integration model:

+
    +
  • +The Hub: DrugBank serves as the anchor, providing +the stable molecular definitions.
    • +
  • +The Spokes: OnSIDES and TWOSIDES provide the +phenotypic and clinical layers.
    • +
+

We introduced specific functions to bridge these worlds. The new +merge_drugbank_onsides() and +merge_drugbank_twosides() functions don’t just combine +lists; they perform intelligent “double joins” and ID mapping (using +RxNorm CUIs) to ensure that your molecular data is correctly linked to +clinical outcomes.

+
+
+

Pipeline-Ready Pharmacovigilance +

+

One of our main design goals was usability. The new merge functions +are “chainable,” meaning they integrate seamlessly with the +tidyverse. You can now build a massive, multi-domain +pharmacovigilance dataset in three lines of R code:

+
+library(dbparser)
+library(dplyr)
+
+final_db <- parseDrugBank("data/drugbank.xml") %>%
+  merge_drugbank_onsides(parseOnSIDES("data/onsides/")) %>%
+  merge_drugbank_twosides(parseTWOSIDES("data/twosides.csv.gz"))
+

The result is a unified dvobject (DrugVerse Object) that +contains mechanistic data, label data, and interaction data, all +enriched with common identifiers.

+
+
+

New Tools for Reproducibility +

+

To support developers and educators, we also exposed our internal +subsetting engines (subset_drugbank_dvobject and +subset_onsides_dvobject). These schema-aware functions +allow you to slice massive databases into consistent, shareable +micro-datasets—perfect for creating unit tests or teaching +materials.

+
+
+

A Scientific Case Study +

+

To demonstrate the power of this new workflow, we included a +comprehensive new vignette: Integrated Pharmacovigilance

+

In this tutorial, we perform a live analysis of +Leuprolide (a hormone therapy) and +Calcitriol (Vitamin D). We define their individual side +effect profiles using OnSIDES, and then use the new TWOSIDES integration +to quantify the specific risks—such as Anaemia—that arise when these two +drugs are prescribed together.

+
+
+

Availability +

+

dbparser 2.2.0 is available now. You can install it from +GitHub to get the latest features immediately, in case it is not +available on CRAN yet.

+
+devtools::install_github("ropensci/dbparser")
+

We look forward to seeing what the community builds with these new +capabilities!

+
+
+
+ + + + +
+ + + + + + + diff --git a/docs/articles/dbparser_2_2.md b/docs/articles/dbparser_2_2.md new file mode 100644 index 00000000..b3eec69a --- /dev/null +++ b/docs/articles/dbparser_2_2.md @@ -0,0 +1,81 @@ +# Introducing dbparser 2.2.0 + +Data in computational pharmacology is often siloed. We have databases +that tell us *what* a drug is (DrugBank), databases that tell us *what +side effects* it causes (OnSIDES), and databases that tell us *how it +interacts* with other drugs (TWOSIDES). + +Connecting these silos has historically been a painful process of manual +mapping and ad-hoc scripting. Today, we are releasing `dbparser` 2.2.0 +to solve this problem once and for all. + +#### The “Hub and Spoke” Architecture + +Version 2.2.0 moves beyond simple XML parsing. We have re-engineered the +package around a “Hub and Spoke” integration model: + +- **The Hub:** DrugBank serves as the anchor, providing the stable + molecular definitions. +- **The Spokes:** OnSIDES and TWOSIDES provide the phenotypic and + clinical layers. + +We introduced specific functions to bridge these worlds. The new +[`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md) +and +[`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md) +functions don’t just combine lists; they perform intelligent “double +joins” and ID mapping (using RxNorm CUIs) to ensure that your molecular +data is correctly linked to clinical outcomes. + +#### Pipeline-Ready Pharmacovigilance + +One of our main design goals was usability. The new merge functions are +“chainable,” meaning they integrate seamlessly with the `tidyverse`. You +can now build a massive, multi-domain pharmacovigilance dataset in three +lines of R code: + +``` r +library(dbparser) +library(dplyr) + +final_db <- parseDrugBank("data/drugbank.xml") %>% + merge_drugbank_onsides(parseOnSIDES("data/onsides/")) %>% + merge_drugbank_twosides(parseTWOSIDES("data/twosides.csv.gz")) +``` + +The result is a unified `dvobject` (DrugVerse Object) that contains +mechanistic data, label data, and interaction data, all enriched with +common identifiers. + +#### New Tools for Reproducibility + +To support developers and educators, we also exposed our internal +subsetting engines (`subset_drugbank_dvobject` and +`subset_onsides_dvobject`). These schema-aware functions allow you to +slice massive databases into consistent, shareable +micro-datasets—perfect for creating unit tests or teaching materials. + +#### A Scientific Case Study + +To demonstrate the power of this new workflow, we included a +comprehensive new vignette: **[Integrated +Pharmacovigilance](https://docs.ropensci.org/dbparser/articles/drugbank_nside.md)** + +In this tutorial, we perform a live analysis of **Leuprolide** (a +hormone therapy) and **Calcitriol** (Vitamin D). We define their +individual side effect profiles using OnSIDES, and then use the new +TWOSIDES integration to quantify the specific risks—such as Anaemia—that +arise when these two drugs are prescribed together. + +#### Availability + +`dbparser` 2.2.0 is available now. You can install it from GitHub to get +the latest features immediately, in case it is not available on CRAN +yet. + +``` r +devtools::install_github("ropensci/dbparser") +``` + +We look forward to seeing what the community builds with these new +capabilities! diff --git a/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.css b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.css new file mode 100644 index 00000000..e3e10e36 --- /dev/null +++ b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.css @@ -0,0 +1,7655 @@ +@charset "UTF-8"; + +/* + * Favorite Colors + * rgb(51, 122, 183) - #337ab7 + * rgb(76, 159, 224) - #4c9fe0 + * rgb(83, 105, 255) - #5369ff + */ + +:root { + /* Colors */ + --cx-color-red: rgb(255, 0, 0); + --cx-color-blue: rgb(0, 0, 255); + --cx-color-green: rgb(0, 255, 0); + --cx-color-yellow: rgb(255, 255, 0); + --cx-color-orange: rgb(255, 165, 0); + --cx-color-purple: rgb(128, 0, 128); + --cx-color-white: rgb(255, 255, 255); + 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Safari */ + -khtml-user-select: none; + /* Konqueror HTML */ + -moz-user-select: none; + /* Old versions of Firefox */ + -ms-user-select: none; + /* Internet Explorer/Edge */ + user-select: none; + /* Non-prefixed version, currently supported by Chrome, Edge, Opera and Firefox */ +} + +/***************** + * SVG No border * + *****************/ + +svg.cX-bin, +svg.cX-code, +svg.cX-chat, +img.CanvasXpressDataFilterToolbarImage, +svg.CanvasXpressDataFilterToolbarImage, +img.CanvasXpressDataFilterToolbarImageNB, +svg.CanvasXpressDataFilterToolbarImageNB { + background: var(--cx-color-transparent) !important; + border: none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: default; + float: right; + margin: 5px 8px 0px 0px !important; +} + +/***************** + * SVG Border * + *****************/ + +svg.cX-code { + border-radius: 5px; + border: var(--cx-border) !important; + padding: 5px; +} + +/***************** + * Loading Timer * + *****************/ + +.cX-loading { + display: inline-block; + position: relative; + width: 80px; + height: 80px; +} + +.cX-loading div { + box-sizing: border-box; + display: block; + position: absolute; + width: 64px; + height: 64px; + margin: 8px; + border: 8px solid var(--cx-color-widgets); + border-radius: 50%; + animation: cX-loading 1.2s cubic-bezier(0.5, 0, 0.5, 1) infinite; + border-color: var(--cx-color-widgets) transparent transparent transparent; +} + +.cX-loading div:nth-child(1) { + animation-delay: -0.45s; +} + +.cX-loading div:nth-child(2) { + animation-delay: -0.3s; +} + +.cX-loading div:nth-child(3) { + animation-delay: -0.15s; +} + +@keyframes cX-loading { + 0% { + transform: rotate(0deg); + } + 100% { + transform: rotate(360deg); + } +} + +/***************** + * Code * + *****************/ + +.cX-code-key { + color: var(--cx-code-key); + font-weight: bold; +} + +.cX-code-value { + color: var(--cx-code-value); +} + +.cX-code-string { + color: var(--cx-code-string); +} + +.cX-code-number { + color: var(--cx-code-number); +} + +.cX-code-boolean { + color: var(--cx-code-boolean); +} + +.cX-code-null { + color: var(--cx-code-null); +} + +.cX-code-comment { + color: var(--cx-code-comment); +} + +div.cX-code, +div.cX-code-container, +div.cX-code-content, +div.cX-code-error { + box-sizing: border-box; +} + +div.cX-code { + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-color-extra-light-gray); + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + padding: 10px 20px 20px 10px; + position: absolute; + white-space: nowrap; +} + +div.cX-code-container { + clear: both; + width: 600px; + overflow: auto; + resize: horizontal; + background-color: var(--cx-color-white); + position: relative; + top: 10px; +} + +div.cX-code-content { + margin: 2px 3px; + padding: 2px 3px; +} + +div.cX-code-error { + height: 36px; + width: 300px; + float: left; + clear: none; + resize: none; + top: 5px; + left: 20px; + background-color: var(--cx-color-extra-light-gray); + overflow: hidden; + white-space: normal; + color: var(--cx-color-red); + position: relative; + cursor: pointer; +} + +pre.cX-code, +pre.cX-code-content, +pre.cX-code-content code { + padding: 0; + margin: 0; + font-size: inherit; + line-height: inherit; + color: inherit; + border: none; +} + +pre.cX-code { + text-align: left; + word-break: inherit; + word-wrap: inherit; + background-color: inherit; + border-radius: inherit; + counter-reset: line; +} + +pre.cX-code-content { + white-space: pre; + outline: none; + cursor: text; + font-size: small; +} + +pre.cX-code-content:before { + counter-reset: listing; +} + +pre.cX-code-content code { + counter-increment: listing; + line-height: 1.5; +} + +pre.cX-code-content code::before { + content: counter(listing) " "; + display: inline-block; + width: 3em; + border-right: 1px solid rgb(221, 221, 221); + text-align: right; + background-color: var(--cx-color-extra-light-gray); +} + +/****************** + * Chat Interface * + ******************/ + +div.cX-chat { + border: none; + background-color: var(--cx-color-transparent); + max-width: 600px; + min-height: 100px; + margin: 10px auto 0 auto; +} + +div.cX-chat-container { + border: none; + border-radius: 10px; + background-color: var(--cx-color-extra-light-gray); + color: var(--cx-font-color); + font: var(--cx-x-large-font); + display: flex; + align-items: center; +} + +div.cX-chat-container-text { + float: left; + border: none; + background-color: var(--cx-color-transparent); + min-height: 50px; +} + +p.cX-chat-question { + border: none; + background-color: var(--cx-color-extra-light-gray); + margin: 0; + display: inline;; +} + +[contenteditable] { + outline: 0px solid transparent; +} + +div.cX-chat-container-icon { + float: right; + border: none; + background-color: var(--cx-color-transparent); +} + +div.cX-chat-container-thumbs { + float: left; + border: none; + background-color: var(--cx-color-transparent); + margin: 0; +} + +svg.cX-chat-thumbs { + background: var(--cx-color-transparent) !important; + border: none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: default; + float: left; +} + +/**************** + * LLM Examples * + ****************/ + +div.cX-LLM-window { + position: absolute; + border: 1px solid #555555; + max-width: 545px; + overflow: hidden; + border-radius: 5px; + background-color: var(--cx-color-extra-light-gray); + z-index: 10000; +} + +a.cX-LLM-window-close { + position: sticky; + top: 0; + left: 500px; + font-size: xx-large; +} + +div.cX-LLM-examples { + position: relative; + overflow: scroll; + max-height: 1000px; +} + +div.cX-LLM-content { + top: 25px; + left: 25px; + position: absolute; +} + +div.cX-LLM-container { + border: 1px solid #d3d3d3; + position: relative; + border-radius: 4px; + background: white; + float: left; + margin: 5px; + max-width: 810px; +} + +div.cX-LLM-title { + position: relative; + height: 40px; + line-height: 40px; + border-radius: 4px; + font-size: 22px; + overflow: hidden; + white-space: nowrap; + text-overflow: ellipsis; + text-align: center !important; + font-weight: bold; + border-bottom: 1px solid var(--cx-color-light-gray); +} + +div.cX-LLM-plot { + display: flex; + align-items: center; + justify-content: center; + margin: 8px; +} + +/*************** + * Bin Data * + ***************/ + +div.cX-bin, +div.cX-bin-name-container { + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; +} + +div.cX-bin { + cursor: move; + color: var(--cx-font-color); + font: var(--cx-large-font); + margin: 2px 3px; + padding: 2px 3px 5px 3px; + position: absolute; + white-space: nowrap; +} + +div.cX-bin-container { + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; + clear: both; + text-align: left; + display: flex; + flex-direction: column; +} + +div.cX-bin-name-container { + box-sizing: border-box; + border: none; + max-height: 400px; + overflow-y: auto; + padding: 5px; +} + +input.cX-bin { + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-large-font); + line-height: 24px; + padding-left: 3px; + border-radius: 5px; + margin: 3px; +} + +input.cX-bin-button { + float: left; + background-color: var(--cx-background-hover-color); + border: var(--cx-border); + border-radius: 5px; + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-large-font-bold); + line-height: 24px; + margin: 0px 10px 10px 10px; + padding: 3px; +} + +table.cX-bin-table { + border-collapse: collapse !important; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-large-font-bold); + line-height: 24px; +} + +th.cX-bin { + text-align: center; + line-height: 24px; + color: var(--cx-font-color); + background-color: var(--cx-background-hover-color); + border: var(--cx-border); + font: var(--cx-large-font-bold); +} + +span.cX-bin { + font: var(--cx-large-font-bold); + color: var(--cx-font-color); + margin-left: 5px; +} + +svg.cX-bin::selection, +span.cX-bin::selection { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + color: rgb(0, 0, 0); + margin: 0px !important; +} + +/* BEGIN OF CUSTOMIZER CSS */ +/* https://cssgrid-generator.netlify.app/ */ + +/* + * CanvasXpress Customizer + */ + +.customizerPanelLeft { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr 8fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + position: fixed; + z-index: 10001; + line-height: 100%; + /*height: calc(100% - 5px);*/ + background-color: rgb(255, 255, 255); + font-family: var(--cx-font-family); + font-weight: normal; + color: var(--cx-font-color); +} + +.customizerLeftPanelTop, +.customizerLeftPanelBottom { + background: var(--cx-background-color); + border-top: var(--cx-border) !important; + border-left: var(--cx-border) !important; + border-bottom: var(--cx-border) !important; + border-right: none !important; +} + +.customizerLeftPanelTop { + grid-area: 1 / 1 / 2 / 2; + border-top-left-radius: 10px; +} + +.customizerLeftPanelBottom { + grid-area: 3 / 1 / 4 / 2; + border-bottom-left-radius: 10px; +} + +.customizerLeftPanelMiddle { + grid-area: 2 / 1 / 3 / 2; + background: var(--cx-color-transparent); +} + +.customizerLeftPanelTop .customizerLeftItem:hover svg, +.customizerLeftPanelTop .customizerLeftItemActive svg, +.customizerLeftPanelBottom .customizerLeftItem:hover svg, +.customizerLeftPanelBottom .customizerLeftItemActive svg { + border: 1px solid rgb(255, 255, 255) !important; + background: var(--cx-color-transparent); +} + +.customizerRightPanel { + background: var(--cx-color-transparent); + position: absolute; + z-index: 10000; + line-height: 100%; + top: 0px; + font-family: var(--cx-font-family); + font-weight: normal; + color: var(--cx-font-color); +} + +.customizerRightPanel { + border-left: var(--cx-border) !important; + border-right: var(--cx-border)!important; +} + +/* + * CanvasXpress Customizer Left Items + */ + +.customizerLeftItem, +.customizerLeftItemActive, +.customizerLeftItemNB { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr 4fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + border-radius: 5px; + align-items: center; +} + +.customizerLeftItem, +.customizerLeftItemActive { + border: var(--cx-border) !important; +} + +.customizerLeftItem:hover, +.customizerLeftItemActive { + background: var(--cx-background-hover-color); +} + +.customizerLeftItem:hover svg, +.customizerLeftItemActive svg { + background: rgb(255, 255, 255); +} + +.customizerLeftItemNB:hover svg { + border-color: var(--cx-background-border-hover-color) !important; + background: var(--cx-background-hover-color) !important; +} + +.customizerLeftItemTop { + grid-area: 1 / 1 / 2 / 2; + margin: auto; + margin-top: 5px; +} + +.customizerLeftItemBottom { + grid-area: 2 / 1 / 3 / 2; + margin: auto; +} + +.customizerLeftIcon, +.customizerLeftIconNB { + padding: 5px; + border-radius: 5px; +} + +.customizerLeftIconNB { + border-width: 1px; + border-style: solid; + border-color: var(--cx-background-color); +} + +.customizerLeftIcon { + border: var(--cx-border) !important; +} + +/* + * CanvasXpress Customizer Right Items + */ + +.customizerRightItem { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 3fr 2fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border-radius: 5px; + width: 95%; +} + +.customizerRightItem { + border: var(--cx-border) !important; +} + +.customizerRightItemTop { + grid-area: 1 / 1 / 2 / 2; + padding-top: 5px; + margin: auto; +} + +.customizerRightItemBottom { + display: grid; + grid-area: 2 / 1 / 3 / 2; + margin: auto; +} + +/* + * CanvasXpress Customizer Right Items Comb + */ + +.customizerRightItemCombo { + display: grid; + grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemCombo { + border-top: var(--cx-border); +} + +.customizerRightItemComboNB { + display: grid; + grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemComboLeft { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboBottomRight { + grid-area: 2 / 2 / 3 / 3; + display: flex; + align-items: center; + padding-left: 15px; + padding-bottom: 2px; +} + +/* + * CanvasXpress Customizer Right Item Header + */ + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + color: var(--cx-font-color); + padding-left: 5px; +} + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + background: var(--cx-background-hover-color); +} + +.customizerRightItemHeader { + border-bottom: var(--cx-border) !important; +} + +.customizerRightItemHeaderNB { + border-bottom: none !important; +} + +.customizerRightItemHeaderTop { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemHeaderBottom { + grid-area: 2 / 1 / 3 / 2; + display: flex; + align-items: center; + padding-left: 10px; + overflow: auto; +} + +.customizerRightItemHeaderMain { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Sub Header + */ + +.customizerRightItemSubHeader { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemSubHeader { + background: var(--cx-background-hover-color); +} + +.customizerRightItemSubHeaderRow { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemSubHeaderRaw { + display: flex; + align-items: center; + border-radius: 5px; +} + +.customizerRightItemSubHeaderRaw { + border: var(--cx-border) !important; + background-color: var(--cx-background-hover-color); +} + +/* + * CanvasXpress Customizer Right Item Launcher + */ + +.customizerRightItemLauncher { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemLauncher { + border-top: var(--cx-border) !important; +} + +.customizerRightItemLauncherNB { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemLauncher:hover, +.customizerRightItemLauncherNB:hover { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemLauncherLeft { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + padding-left: 5px; +} + +/* + * CanvasXpress Customizer Right Item Input + */ + +.customizerRightItemInput { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: repeat(2, 1fr); + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemInputTopLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemInputTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; +} + +.customizerRightItemInputBottom { + grid-area: 2 / 1 / 3 / 3; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Cols + */ + +.customizerRightItemFullCol { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemHalfCol { + display: grid; + grid-template-columns: repeat(2, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemThirdCol { + display: grid; + grid-template-columns: repeat(3, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFourthCol { + display: grid; + grid-template-columns: repeat(4, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFifthCol { + display: grid; + grid-template-columns: repeat(5, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemSixthCol { + display: grid; + grid-template-columns: repeat(6, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemCol1 { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol2 { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol3 { + grid-area: 1 / 3 / 2 / 4; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol4 { + grid-area: 1 / 4 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol5 { + grid-area: 1 / 5 / 2 / 6; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol6 { + grid-area: 1 / 6 / 2 / 7; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemColMid { + grid-area: 1 / 3 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; + border-radius: 5px; +} + +.customizerRightItemColMid { + border: var(--cx-border) !important; +} + +.customizerRightItemSelect>select:hover, +.customizerRightItemTextArea>svg:hover, +.customizerRightItemTextArea>textarea:hover, +.customizerContainerRaw>svg:hover, +.customizerRightItemCol1>svg:hover, +.customizerRightItemCol2>svg:hover, +.customizerRightItemCol3>svg:hover, +.customizerRightItemCol4>svg:hover, +.customizerRightItemCol5>svg:hover, +.customizerRightItemCol6>svg:hover, +.customizerRightItem:hover { + background-color: var(--cx-background-hover-color); +} + +/* + * Other Customizer classes + */ + +.customizerContainer { + height: fit-content; + border-radius: 5px; + margin: 10px; + float: left; +} + +.customizerWrangling { + height: 102px; + margin: 0px 0px 10px 10px; + border-radius: 5px; + overflow-y: auto; + overflow-x: hidden; +} + +.customizerNumeric, +.customizerString, +.customizerUnique, +.customizerWrangling, +.customizerContainer { + border: var(--cx-border) !important; +} + +.customizerWrangling:hover { + border: 1px dashed var(--cx-color-red) !important; +} + +.customizerContainerRaw { + border: none !important; + float: left; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerMask { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + position: absolute; + left: 0px; + top: 0px; + margin: 0px !important; + width: 100%; + height: 20px; +} + +.customizerNumeric, +.customizerString, +.customizerUnique { + border-radius: 5px; + cursor: move; + margin: 3px; + padding: 3px; + word-wrap: normal; + display: inline-block; + text-align: start; + max-width: 150px; + overflow: hidden; + position: relative; +} + +.customizerNumeric { + color: var(--cx-font-color); + background-color: var(--cx-color-transparent); +} + +.customizerString { + color: var(--cx-color-green); + background-color: var(--cx-color-transparent); +} + +.customizerUnique { + color: var(--cx-color-blue); + background-color: var(--cx-color-transparent); +} +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + border: none; + cursor: move; + color: var(--cx-font-color); + margin: 0; + padding: 0 0 0 3px; + width: 350px; + white-space: nowrap; + display: inline-block; + text-align: start; + overflow: hidden; + position: relative; +} + +.customizerListNumeric { + color: var(--cx-font-color); +} + +.customizerListString { + color: var(--cx-color-green); +} + +.customizerListUnique { + color: var(--cx-color-blue); +} + +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + background-color: var(--cx-color-transparent); +} + +.customizerListNumeric:hover, +.customizerListString:hover, +.customizerListUnique:hover { + background: var(--cx-background-hover-color); +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + font: normal 10px courier; +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + color: var(--cx-background-color); +} + +.customizerListNumeric:before { + content: "\00a0#\00a0\00a0"; +} + +.customizerListString:before { + content: "Abc\00a0"; +} + +.customizerListUnique:before { + content: "Unq\00a0"; +} + +.customizerMask::selection, +.customizerNumeric::selection, +.customizerString::selection, +.customizerUnique::selection, +.customizerListNumeric::selection, +.customizerListString::selection, +.customizerListUnique::selection { + background: var(--cx-color-transparent); + color: var(--cx-color-black); + padding: 0; +} + +/* + * Search Customizer + */ + +input.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + height: 40px; + border-radius: 4px; + float: left; + clear: left; +} + +select.customizerSearch, +input.customizerSearch { + border: var(--cx-border); +} + +input.customizerSearch[type="color"] { + padding: 0; + overflow: hidden; +} + +input.customizerSearch:not([type="color"]) { + padding: 5px; +} + +select.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + padding-left: 3px; + border-radius: 4px; + float: left; + clear: left; +} + +span.customizerSearch { + color: var(--cx-font-color); + font: inherit; + line-height: 20px; + list-style: none; + position: relative; + margin: 5px 5px 0 15px; + float: left; + clear: left; +} + +span.customizerSearchSelect, +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + font: inherit; + line-height: 28px; + list-style: none; + position: relative; + height: 28px; + margin-top: 5px; + float: left; + clear: left; + left: 15px; +} + +span.customizerSearchSelect { + color: var(--cx-font-color); +} + +span.customizerSearchDescription, +span.customizerSearchCategory { + overflow: hidden; + text-overflow: ellipsis; + white-space: nowrap; +} + +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + color: var(--cx-background-color); +} + +span.customizerSearchSelect:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Select property ("; +} + +span.customizerSearchSelect:after { + color: var(--cx-font-color); + font-weight: bold; + content: ")"; +} + +span.customizerSearchDescription:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Description [ "; +} + +span.customizerSearchCategory:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Category [ "; +} + +span.customizerSearchDescription:after, +span.customizerSearchCategory:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +span.customizerSearchCurrent:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Current Value [ "; +} + +span.customizerSearchCurrent:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +/* + * Password + */ + +div.CanvasXpressPassword { + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: normal 16px arial, tahoma, sans-serif; + margin: 2px 3px; + overflow: hidden; + padding: 1px 12px; + width: 200px; + height: 185px; + white-space: nowrap; + position: relative; + text-align: left; +} + +img.CanvasXpressPassword, +svg.CanvasXpressPassword { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgb(0 0 0 / 0%) !important; + box-sizing: border-box; + cursor: default; + float: right; + margin: 5px 0px 0px 0px !important; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressPasswordContainer { + box-sizing: border-box; + border-radius: 0px 0px 5px 5px; + color: var(--cx-font-color); + display: block; + left: 0px; + line-height: 100%; + position: relative; + top: 15px; + margin-top: 5px; + -ms-user-select: none; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +span.CanvasXpressPassword { + margin-bottom: 5px; + margin-left: 5px; + float: left; +} + +input.CanvasXpressPassword { + float: left; + margin-bottom: 5px; + padding: 5px; + border-radius: 5px; + border: 1px solid rgb(170, 170, 170); + width: 170px; +} + +/* + * CanvasXpressDrag + */ + +div.CanvasXpressDrag { + opacity: 0.75; + box-sizing: border-box; + filter: alpha(opacity=75); + background-color: rgba(255, 255, 255, 0.95); + position: absolute; +} + +div.CanvasXpressDragLayout { + opacity: 0.65; + box-sizing: border-box; + filter: alpha(opacity=65); + background-color: rgba(51, 122, 183, 0.65); + position: absolute; +} + +/* + * Tooltip + */ + +div.CanvasXpressTooltip { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; +} + +div.CanvasXpressTooltipInfo { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + max-height: 800px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +/*****************************************************/ +/* Generators */ +/* A collection of Tooltips/Speech Bubbles */ +/* https://css-generators.com/tooltip-speech-bubble/ */ +/*****************************************************/ + +div.CanvasXpressTooltipInfoNone, +div.CanvasXpressTooltipInfoBottom, +div.CanvasXpressTooltipInfoTop, +div.CanvasXpressTooltipInfoLeft, +div.CanvasXpressTooltipInfoRight { + color: var(--cx-font-color); + font: var(--cx-font); + max-height: 800px; + padding: 10px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressTooltipInfoBottom { + border-radius: var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) / + var(--cx-callout-radius); + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 100%, + 50% calc(100% + var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 100% + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + var(--cx-callout-radius) max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / 0 0 + var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoBottom:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)), + 50% + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / 0 0 var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoTop { + border-radius: min( + var(--cx-callout-radius), + 50% - var(--cx-callout-size) * tan(45deg) + ) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) / var(--cx-callout-radius); + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 0, + 50% calc(-1 * var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / var(--cx-callout-size) + 0 0 0; +} + +div.CanvasXpressTooltipInfoTop:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width), + 50% + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0/ 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) var(--cx-callout-radius) max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / var(--cx-callout-size) 0 0 0; +} + + +div.CanvasXpressTooltipInfoLeft { + border-radius: var(--cx-callout-radius) / + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)); + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + 0 min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(-1 * var(--cx-callout-size)) 50%, + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0/0 0 0 + var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoLeft::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + var(--cx-callout-border-width) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)) + 50%, + var(--cx-callout-border-width) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0/0 0 0 var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoRight { + border-radius: var(--cx-callout-radius) / var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius); + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + 100% min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(100% + var(--cx-callout-size)) 50%, + 100% max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) / + 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressTooltipInfoRight::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + calc(100% - var(--cx-callout-border-width)) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ) + 50%, + calc(100% - var(--cx-callout-border-width)) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) / 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +img.CanvasXpressMousePosition, +svg.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + margin: 0px !important; + padding: 0px !important; + position: relative; + left: -13px; + top: -13px; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +span.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + left: 4px; + top: -20px; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressCanvasResizerClose { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAkAAAAOCAYAAAD9lDaoAAAAcUlEQVR42mM8e/bsfwYCgBGkSE9PD6eCS5cuIRSxsrIy/P79Gy4J42MoAgGQBDIbRRFMNwzATMVQhGwNVjehm/T582cwfevWLfxu+vTpO8Pt29ew++7Hjx8MvLy8mIpgAKTg/38WOB+uiGCIE1JAXUUA5WZpcWW3WYkAAAAASUVORK5CYII=); +} + +div.CanvasXpressCanvasResizerloading1 { + box-sizing: border-box; + background-image: 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5BvgPpYtzj9W+TNwUHDR4QqBAgr1bdIBzMlzCGgX8EFtTD1sBTPgQFRv/6YTAgDzgAJfP5eslDAAMFDTrS3Mmzp8+fQIMKHUq0qNGjSJMisYNR6YotCBAE9GPAgE6fEKJqnbiiQYQCYCmaePDgBNmyJc6mVUuC7Ai3AOC+ZWuipAStUQusGFDgawQFK+TOjYtWhFvBhwsTnlsWseITDfDibVoCAtivgFUINtxY8VnHiwdz/ty2MwoBkrVSJtEAbNjAjxeDnu25cOLaoU2sSa236wCrKglvpss5t/DHcuEO31z57laxTisniErganQSNldf3869u/fv4MOLH0++vHk/A5YQeISjQfBr6yTIl5/Sxp2/76sNmM9fuwsDESyAHzgJ8DdfbzN4JWCkBBFYd40DBsqXgA0DMIhMfsQUGGEENjRQIR4v7Rehfy9gWE18/DkEnh0RJELieTDGKOOMNAa1DlkS1Bceap894ICJUNjhCJAyFNAjWahAA8ECTKrow5FkIVDNMcgMAwSUzFnCAJMLvHiDBFBKWQ1LLgERAZRJBpVTiQ70eMBQDSigAHSnLYCAj2kCJYCcBjwz3h98EnkUM1adJ2iNiCaq6KKLhgAAIfkECQcAAAAsAAAAAGQAZAAABf8gII5kaZ5oqq5s675wLM90bd94ru987//AoHAYEywShIWAyKwtCMjEokmFCaJQwrLKVTWy0UZ3jCqAC+SfoCF+NQrIQrvFWEQU87RpQOgbYg0MMAwJDoUEeXoiX2Z9iT0LhgmTU4okEH0EZgNCk4WFEZYkX5kEEEJwhoaVoiIGmklDEJOSgq0jDAOnRBBwBba3wcLDxMXGx8jJysvMzUJbzgAGn7s2DQsFEdXLCg4HDt6cNhHZ2dDJAuDqhtbkBe+Pxgze4N8ON+Tu58jp6+A3DPJtU9aNnoM/OBrs4wYuAcJoPYBBnEixosWLGDNq3Mixo8ePIEOKxGHEjIGFKBj/DLyY7oDLA1pYKIgQQcmKBw9O4MxZYmdPnyRwjhAKgOhQoCcWvDyA4IC4FAHtaLvJM2hOo0WvVs3K9ehRrVZZeFsKc0UDmnZW/jQhFOtOt2C9ingLt+uJsU1dolmhwI5NFVjnxhVsl2tdwkgNby0RgSyCpyogqGWbOOvitlvfriVc2LKKli9jjkRhRNPJ0ahTq17NurXr17Bjy55NG0UDBQpOvx6AoHdTiTQgGICsrIFv3wdQvoCwoC9xZAqO+34Ow0DfBQ+VEZDeW4GNOgsWTC4WnTv1QQaAJ2vA9Hhy1wPaN42XWoD1Acpr69/Pv79/ZgN8ch5qBUhgoIF7BSMAfAT07TDAgRCON8ZtuDWYQwIQHpigKAzgpoCEOGCYoQQJKGidARaaYB12LhAwogShKMhAiqMc8JYDNELwIojJ2EjXAS0UCOGAywxA105EjgBBBAlMZdECR+LESmpQRjklagxE+YB6oyVwZImtCUDAW6K51mF6/6Wp5po2hAAAIfkECQcAAAAsAAAAAGQAZAAABf8gII5kaZ5oqq5s675wLM90bd94ru987//AoHAYE0AWC4iAyKwNCFDCoEmFCSJRQmRZ7aoaBWi40PCaUc/o9OwTNMqvhiE84LYYg4GSnWpEChEQMQ0MVlgJWnZ8I36AgHBAT4iIa4uMjo9CC5MECZWWAI2Oij4GnaefoEcFBYVCAlCIBK6gIwwNpEACCgsGubXAwcLDxMXGx8jJysvMZ7/KDAsRC5A1DQO9z8YMCQ4J39UzBhHTCtrDAgXf3gkKNg3S0hHhx9zs3hE3BvLmzOnd6xbcYDCuXzMI677RenfOGAR1CxY26yFxosWLGDNq3Mixo8ePIEOKHEmyZDEBAwz/GGDQcISAlhMFLHBwwIEDXyyOZFvx4MGJnj5LABU6lETPEUcBJEVa9MQAm1Ad0CshE4mCqUaDZlWqlatXpl9FLB26NGyKCFBr3lyxCwk1nl3F+iwLlO7crmPr4r17NqpNAzkXKMCpoqxcs0ftItaaWLFhEk9p2jyAlSrMukTjNs5qOO9hzipkRiVsMgXKwSxLq17NurXr17Bjy55Nu7ZtIoRWwizZIMGB3wR2f4FQuVjv38gLCD8hR8HVg78RIEdQnAUD5woqHjMgPfpv7S92Oa8ujAHy8+TZ3prYgED331tkp0Mef7YbJctv69/Pv7//HOlI0JNyQ+xCwHPACOCAmV4S5AfDAAhEKF0qfCyg14BANCChhAc4CAQCFz6mgwIbSggYKCGKmAOJJSLgDiggXiiBC9cQ5wJ3LVJ4hoUX5rMCPBIEKcFbPx5QYofAHKAXkissIKSQArGgIYfgsaGAki62JMCTT8J0Wh0cQcClkIK8JuaYEpTpGgMIjIlAlSYNMKaOq6HUpgQIgDkbAxBAAOd/gAYqKA0hAAAh+QQJBwAAACwAAAAAZABkAAAF/yAgjmRpnmiqrmzrvnAsz3Rt33iu73zv/8CgcChrQAYNotImiBQKi+RyCjM4nwOqtmV4Og3bcIpRuDLEaBNDoTjDGg1BWmVQGORDA2GfnZusCxFgQg17BAUEUn4jEYGNQwOHhhCLJFYREQpDEIZ7ipUCVgqfQAt7BYOVYkduqq6vsLGys7S1tre4ubq7UwIDBn04DAOUuwJ7CQQReDUMC8/FuXrJydE0Bs92uwvUBAnBNM7P4LcK3ufkMxDAvMfnBbw9oQsDzPH3+Pn6+/z9/v8AAwocSLCgwYO9IECwh9AEBAcJHCRq0aAOqRMPHmDMaCKjRhIeP47gKIIkyZEeU/8IgMiSABc2mlacRAlgJkebGnGizCmyZk8UAxIIHdoqRR02LGaW5AkyZFOfT5c6pamURFCWES+aCGWgKIqqN3uGfapzqU+xTFEIiChUYo+pO0uM3fnzpMm6VUs8jDixoVoIDBj6HUy4sOHDiBMrXsy4sWMSTSRkLCD4ltcZK0M+QFB5lgIHEFPNWKB5cq7PDg6AFh0DQem8sVaCBn0gQY3XsGExSD0bdI0DryXgks0bYg3SpeHhQj07HQzgIR10lmWAr/MYC1wjWDD9sffv4MOLR3j1m5J1l/0UkMCevXIgDRIcQHCAQHctENrrv55D/oH/B7ynnn7t2fYDAwD+R59zVmEkQCB7BvqgQIIAphdGBA9K4JILcbzQAID0/cfgFvk9aE0KDyFA34kp+AdgBK4MQKCAKEqg4o0sniBAAQBS9goEESQQQY4nJHDjjRGy0EBg/Rx55GFO3ngYAVFuWBiCRx4w4kENFKBiAVuOJ+aYZIoZAgAh+QQJBwAAACwAAAAAZABkAAAF/yAgjmRpnmiqrmzrvnAsz3Rt33iu73zv/8CgcChrMBoNotImUCwiiuRyCoNErhEIdduCPJ9arhgleEYWgrHaxIBAGDFkep1iGBhzobUQkdJLDAtOYUENEXx8fn8iBguOBkMNiImLJF6CA0MCBYh9lSMCEAYQikAMnBFwn2MCRquvsLGys7S1tre4ubq7vDqtpL5HvAIGBMYDeTTECgrJtwwEBcYEzjIMzKO7A9PGpUUGzN61EMbSBOIxoei0ZdOQvTuhAw3V8Pb3+Pn6+/z9/v8AAwocSBCQo0wFUwhI8KDhgwPrerUSUK8EAYcOD/CTRCABGhUMMGJ8d6JhSZMlHP+mVEkCJQCULkVgVFggQUcCC1QoEOlQQYqYMh+8FDrCZEyjRIMWRdoyaZ2bNhOoOmGAZ8OcKIAO3bqUpdKjSXk25XqiQdSb60JaJWlCK9OlZLeChetVrtMSm85iTXFRpMafdYfefRsUqEuYg7WWkGTTk4qFGB1EHEavIpuDCTNr3sy5s+fPoEOLHk063YCaCZD1mlpjk4TXrwtYjgWh5gLWMiDA3o3wFoQECRwExw2jwG7YCXDlFS58r4wEx187wMUgOHDgEWpEiC4h+a281h34pKE7em9b1YUDn7xiwHHZugKdYc/CSoIss0vr38+/v//RTRAQhRIC4AHLAAcgoCCkAuf50IACDkTYzCcCJLiggvTRAKEDB0TIFh0GXLjgeD4wwGGEESaQIREKiKggiT2YiOKJxI0xgIsIfKgCPS+YFWGHwq2oiYULHpCfCFZE+FELBszoQIN0NEDkATWaIACHB2TpwJEAEGOdaqsIMIACYLKwQJZoHuDcCkZweUsBaCKQJQGfEZBmlgV8ZkCCceqYWXVpUgOamNEYIOR/iCaq6KIAhAAAIfkECQcAAAAsAAAAAGQAZAAABf8gII5kaZ5oqq5s675wLM90bd94ru987//AoHBIExCPOMhiAUE6ZYLl0vissqJSqnWLGiwUA64Y1WiMfwKGmSgwgM+otsKwFhoWkYgBbmIo/gxEeXgLfCUNfwp1QQp4eoaHakdRelqQl5iZmpucnZ6foKGioz8LCA8IC5akOAcPr68Oq6CzMguwuAWjEBEFC4syDriwEqICvcg2w7iiDQXPBRHAMKfLD8bR0RE2t8u6ogzPEU01AsK4ErWdAtMzxxKvBeqs9PX29/j5+vv8/f7/AAMKNAEBwryBJAYgkMCwEMIUAxhKlOBQn4AB0cKsWDiRYTsRr07AMjGSBDOT10D/pgyJkmUXAjAJkEMBoaPEmSRTogTgkue1niGB6hwptAXMAgR8qahpU4JGkTpHBI06bGdRlSdV+lQRE6aCjU3n9dRatCzVoT/NqjCAFCbOExE7VoQ6tqTUtC2jbtW6967eE2wjPFWhUOLchzQNIl7MuLHjx5AjS55MubJlGQ3cKDj4kMEBBKARDKZ1ZwDnFQI+hwb9UZMAAglgb6uhcDXor6EUwN49GoYC26AJiFoQu3jvF7Vt4wZloDjstzBS2z7QWtPuBKpseA594LinAQYU37g45/Tl8+jTq19fmUF4yq8PfE5QPQeEAgkKBLpUQL7/BEJAkMCADiSwHx8NyIeAfH8IHOgDfgUm4MBhY0Dg34V7ACEhgQnMxocACyoon4M9EBfhhJdEcOEBwrkwQAQLeHcCAwNKSEB9VRzjHwHmAbCAA0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); + background-position: 50% 50%; + background-repeat: no-repeat; +} + +/********** + * Motion * + **********/ + +div.CanvasXpressMotion { + color: var(--cx-font-color); + font: var(--cx-font); +} + +img.CanvasXpressMotion, +svg.CanvasXpressMotion { + margin: 0px !important; + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; +} + +div.CanvasXpressMotionContainer { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAF0lEQVR42mNkAAJGNOLChQv/cRNYdAAA0dgUqRX/AM0AAAAASUVORK5CYII=); + background-repeat: repeat-x; +} + +div.CanvasXpressMotionCurrent { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAAlUlEQVR42mNkgIIDBw78ZyACODg4MCLzGWGa7e3tidHPcPDgQRRDGEGaTc0tidIMA6dPHocbAjZAV9eQJAMuXz5PZQM0NA1IMuDG9QuoBqioqJBkwJ07d1ANkJRWJ8mA509vUtkAUVFFkgx4/fo+qgG8fHIkGfD50yMqGgAiQIaws4oTpfnn75eoSRnGoCgzUQIoNgAAbjRcEcsB8BEAAAAASUVORK5CYII=); + background-repeat: no-repeat; + float: left; + height: 14px; + position: relative; + width: 14px; + z-index: 1000002; +} + +div.CanvasXpressMotionRange { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAFklEQVR42mNkAAJGNMKxcdd/3AQWHQAD/g7xOirtNAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + float: left; + height: 14px; + left: 0px; + top: -1px; + position: relative; + z-index: 1000001; +} + +/********* +* Marker * +**********/ + +div.CanvasXpressMarker { + box-sizing: border-box; + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + cursor: move; + font: var(--cx-font); + height: 502px; + width: 286px; + left: 0px; + line-height: 100%; + position: absolute; + top: 0px; + padding: 2px; +} + +/************* + * Toolbar * + *************/ + +div.CanvasXpressToolbarTop { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarTopContainer { + border: var(--cx-border); + border-radius: 0 0 8px 8px; + border-top: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer { + border: var(--cx-border); + border: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopOverContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarTopContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarBottom { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarBottomContainer { + border: var(--cx-border); + border-radius: 8px 8px 0 0; + border-bottom: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarBottomRound { + border-radius: 50%; + overflow: hidden; +} + +div.CanvasXpressToolbarBottomRound, +div.CanvasXpressToolbarBottomStripe { + cursor: pointer; + float: left; +} + +div.CanvasXpressToolbarLeft { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarLeftContainer { + border: var(--cx-border); + border-radius: 0 8px 8px 0; + border-left: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarLeftContainer img.CanvasXpressToolbarLeftImage, +div.CanvasXpressToolbarLeftContainer svg.CanvasXpressToolbarLeftImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarRight { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarRightContainer { + border: var(--cx-border); + border-radius: 8px 0 0 8px; + border-right: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarRightFont { + padding: 5px; + cursor: pointer; +} + +/************* + * Tooltip * + *************/ +div.CanvasXpressAltTooltip { + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 5px; + box-shadow: 0 0 5px var(--cx-color-transparent); + color: var(--cx-font-color); + font: var(--cx-font); + font-size: var(--cx-font-size); + line-height: 100%; + padding: 5px; + position: absolute; + display: none; + text-wrap: nowrap; + z-index: 1000000; +} + +/****************** + * Data Table DOE * + ******************/ + +table.CanvasXpressDataTableDOE { + border-spacing: 0 !important; + font-size: var(--cx-font-size) !important; + padding: 0 !important; + border: none !important; +} + +th.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + font-weight: bold !important; + padding-left: 5px !important; + padding-right: 5px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +td.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + padding-left: 5px !important; + padding-right: 18px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +tr.CanvasXpressDataTableDOE { + font-size: var(--cx-font-size) !important; +} + +/****************/ +/* Data Table */ +/****************/ + +div.CanvasXpressDataTableUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,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'); + background-size: contain; + background-repeat: no-repeat; + position: relative; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableContainer, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal, +div.CanvasXpressDataTableMask { + box-sizing: border-box; + position: absolute; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal { + color: var(--cx-font-color); + background-color: var(--cx-background-widgets-color) +} + +div.CanvasXpressDataTable { + border: var(--cx-border); + border-radius: 5px; + clear: both; + overflow: hidden; +} + +div.CanvasXpressDataTableToolbar { + border-bottom: var(--cx-border); + border-radius: 5px 5px 0px 0px; + height: 36px; + left: 0px; + line-height: 100%; + top: 0px; +} + +div.CanvasXpressDataTableContainer { + border-radius: 0px 0px 5px 5px; + display: block; + left: 0px; + line-height: 100%; +} + +div.CanvasXpressDataTableVertical { + overflow-x: hidden; + overflow-y: auto; + right: 6px; + top: 2px; + width: 16px; +} + +div.CanvasXpressDataTableHorizontal { + bottom: 12px; + height: 16px; + left: 2px; + overflow-x: auto; + overflow-y: hidden; +} + +div.CanvasXpressDataTableMask { + border: 0px; + top: 0px; + overflow: hidden; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage, +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + background: var(--cx-color-transparent) !important; + border-radius: 5px; + padding: 2px; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px !important; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage { + border: var(--cx-border) !important; +} + +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + border: none !important; +} + +img.CanvasXpressDataTableToolbarImageLogo, +svg.CanvasXpressDataTableToolbarImageLogo { + border: none !important; + float: left; + margin: 5px 0px 0px 10px !important; +} + + +img.CanvasXpressDataTableVertical { + max-height: unset !important; + height: revert-layer !important; +} + +img.CanvasXpressDataTableHorizontal { + max-width: unset !important; +} + +table.CanvasXpressDataTable { + border: 0px; + border-spacing: 1px; + color: var(--cx-font-color); + left: 1px; + position: absolute; + opacity: 0.95; + table-layout: fixed; + top: 1px; +} + +th.CanvasXpressTableCellHead, +th.CanvasXpressTableCellHeadActive { + border-top: none; + border-bottom: var(--cx-border-transparent); + border-left: none; + border-right: var(--cx-border-transparent); + font-weight: normal; + opacity: 0.95; + padding: 2px; + vertical-align: middle; +} + +tr > th.CanvasXpressTableCell:last-child, +tr > th.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +th.CanvasXpressTableCellHead { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +th.CanvasXpressTableCellHeadActive { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHead, +a.CanvasXpressTableCellHeadActive { + cursor: pointer; + position: absolute; + right: 8px; + white-space: normal; + text-decoration: none; + font-style: normal; + width: 14px; +} + +a.CanvasXpressTableCellHead { + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHeadActive { + color: var(--cx-background-color); +} + +td.CanvasXpressTableCell, +td.CanvasXpressTableCellActive { + border-top: none !important; + border-bottom: var(--cx-border-transparent); + border-left: none !important; + border-right: var(--cx-border-transparent); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + padding: 2px !important; + vertical-align: middle; +} + +tr > td.CanvasXpressTableCell:last-child, +tr > td.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +div.CanvasXpressTableCell, +div.CanvasXpressTableCellLink { + box-sizing: border-box; + color: var(--cx-font-color); + margin: 2px 2px 1px 5px; + overflow: hidden; + position: relative; + text-align: left; + white-space: pre-wrap; + word-break: break-word; +} + +div.CanvasXpressTableCell:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressTableCellLink:hover { + background-color: var(--cx-background-hover-color); + text-decoration: underline var(--cx-border); + cursor: pointer; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell, +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + border-radius: 5px; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell { + /* border: var(--cx-border-transparent); */ +} + +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + /* border: var(--cx-border) */ +} + +/***************/ +/* Data Filter */ +/***************/ + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar, +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive, +select.CanvasXpressDataFilterContainerString { + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar { + box-sizing: border-box; + line-height: 100%; + margin: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterToolbar { + border: var(--cx-border) !important; + border-radius: 4px; + left: 0px; + opacity: 0.95; + top: 0px; +} + +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive { + left: 8px; + line-height: 100%; + position: relative; + top: 9px; + background-repeat: no-repeat; + background-position: -0px; +} + +select.CanvasXpressDataFilterContainerString { + background-color: var(--cx-background-widgets-color); + margin-left: 3px; + margin-bottom: 3px; +} + +div.CanvasXpressDataFilterContent { + box-sizing: border-box; + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 0px 0px 4px 4px; + border-top: 0px; + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); + overflow-y: auto; + overflow-x: hidden; + padding: 2px; +} + +input[type=checkbox].CanvasXpressCheckbox { + accent-color: var(--cx-background-accent-color); + border-radius: 5px; + height: 14px; + width: 14px; + margin: 2px; +} + +label.CanvasXpressCheckboxLabel { + width: 220px; + text-overflow: ellipsis; + white-space: nowrap; + overflow-x: hidden; + margin: 0 0 0 3px !important; +} + +div.CanvasXpressDataFilterContainer, +div.CanvasXpressDataFilterContainerMask, +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable { + box-sizing: border-box; +} + +div.CanvasXpressDataFilterContainer { + border: 0px; + left: 0px; + margin: 0px; + padding: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterContainerMask { + border: var(--cx-border); + margin: 5px; + overflow-x: hidden; + overflow-y: scroll; +} + +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected { + height: 20px; + padding: 1px 0px 0px 1px; + overflow: hidden; + white-space: nowrap; +} + +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressDataFilterContainerHoverable { + border: var(--cx-border); + border-radius: 5px; + margin: 2px; + margin-bottom: 4px; +} + +div.CanvasXpressDataFilterHead, +div.CanvasXpressDataFilterHeadActive { + border: var(--cx-border); + border-radius: 4px; + box-sizing: border-box; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 38px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + text-align: left; + vertical-align: middle; +} + +div.CanvasXpressDataFilterHeadActive { + background:var(--cx-background-hover-color); + border-bottom: var(--cx-border-transparent) !important; + border-radius: 4px 4px 0px 0px; +} + +div.CanvasXpressDataFilterContainerTicks { + display: flex; + justify-content: space-between; + padding: 0px 10px; + height: 18px; +} + +span.CanvasXpressDataFilterContainerTicks, +span.CanvasXpressDataFilterContainerTicksLong { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + line-height: 10px; + margin-bottom: 10px; +} + +span.CanvasXpressDataFilterContainerTicks { + height: 5px; +} + +span.CanvasXpressDataFilterContainerTicksLong { + height: 10px; +} + +img.CanvasXpressDataFilterToolbarImage, +svg.CanvasXpressDataFilterToolbarImage { + border: var(--cx-border) !important; + border-radius: 5px !important; + padding: 2px; +} + +img.CanvasXpressDataFilterToolbarImageNB, +svg.CanvasXpressDataFilterToolbarImageNB { + border: none !important; +} + +span.CanvasXpressDataFilterText { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASElEQVR42mNkoBAwUt2A/0AAlgACsg0A6QWZQ4whOA2AsgkagtcAYgwhaAAhQ4gyAJ8htHcBRWFAUSxQlA7AEuSmRFLBwBsAAMDpRxF7e4BAAAAAAElFTkSuQmCC); +} + +span.CanvasXpressDataFilterTextActive { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASUlEQVR42mNkoBAwjhqAMOA/EBCtCQiwGoAkjhOA7MFqADGGoGvGGga4DMGmGWcgohuCSzNOA5ANwacZrwFIhuBVM4gS0oAZAAD1oisRsByngAAAAABJRU5ErkJggg==); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow, +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + box-sizing: border-box; + margin: 5px; + overflow: hidden; +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow { + border: var(--cx-border); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + border: none; +} + +input.CanvasXpressDateFilterContainerInputLeft { + float: left; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +input.CanvasXpressDateFilterContainerInputRight { + float: right; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +/***************/ +/* Toggle */ +/***************/ + +div.CanvasXpressToggle { + border: none; + margin: 5px; + height: 18px; +} + +label.CanvasXpressToggle { + cursor: pointer; +} + +div.CanvasXpressToggleSwitch { + display: inline-block; + background: rgb(204, 204, 204); + border-radius: 16px; + width: 28px; + height: 18px; + position: relative; + vertical-align: middle; + transition: background 0.25s; +} + +div.CanvasXpressToggleSwitch:before, +div.CanvasXpressToggleSwitch:after { + content: ""; +} + +div.CanvasXpressToggleSwitch:before { + display: block; + background: linear-gradient(to bottom, rgb(255, 255, 255) 0%, rgb(238, 238, 238) 100%); + border-radius: 50%; + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.25); + width: 14px; + height: 14px; + position: absolute; + top: 2px; + left: 2px; + transition: left 0.25s; +} + +label.CanvasXpressToggle:hover div.CanvasXpressToggleSwitch:before { + background: linear-gradient(to bottom, rgb(255, 255, 255)0%, rgb(255, 255, 255)100%); + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.5); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch { + background: var(--cx-background-color); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch:before { + left: 12px; +} + +input.CanvasXpressToggle { + position: absolute; + visibility: hidden; +} + +span.CanvasXpressToggle { + margin-left: 5px; + margin-right: 5px; + position: relative; +} + +/****************/ +/* Range Slider */ +/****************/ + +div.CanvasXpressRangeSliderContainer { + border: none; + margin: auto; + height: 110px; +} + +div.CanvasXpressRangeSliderContainerTop { + height: 18px; + margin: 5px; + position: relative; + display: flex; +} + +span.CanvasXpressRangeSliderContainerTop { + border: none; +} + +div.CanvasXpressRangeSliderContainerBottom { + height: 80px; + position: relative; +} + +div.CanvasXpressRangeSliderInput { + position: relative; + z-index: 10001; + height: 22px; + margin: 8px 0; +} + +input.CanvasXpressRangeSliderMin, +input.CanvasXpressRangeSliderMax { + color: var(--cx-background-color); + border: 1px solid var(--cx-background-widgets-color); + border-radius: 5px; + font: var(--cx-font); + margin-bottom: 2px; + line-height: 100%; + width: 60px; +} + +input.CanvasXpressRangeSliderMin { + float: left; + margin-left: 1px; +} + +input.CanvasXpressRangeSliderMax { + float: right; + margin-right: 1px; + text-align: right; +} + +div.CanvasXpressRangeSlider { + position: relative; + z-index: 10001; + height: 8px; + margin: 0 15px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderTrack { + position: absolute; + z-index: 10001; + left: 0; + right: 0; + top: 0; + bottom: 0; + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderRange { + background-color: var(--cx-background-color); + position: absolute; + z-index: 10002; + left: 0%; + right: 0%; + top: 0; + bottom: 0; + border-radius: 5px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + position: absolute; + z-index: 10003; + width: 18px; + height: 18px; + border-radius: 50%; + transition: box-shadow .3s ease-in-out; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + background-color: var(--cx-background-color); + box-shadow: 0 0 0 0 var(--cx-background-hover-color); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft { + left: 0%; + transform: translate(-15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + right: 0%; + transform: translate(15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft:hover, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight:hover { + box-shadow: 0 0 0 10px var(--cx-background-hover-color); +} + +input[type=range].customizerRightItemRangeSelect { + -webkit-appearance: none; + appearance: none; + width: 100%; + height: 8px; + border-radius: 5px; + background: var(--cx-color-extra-light-gray); + outline: none; + opacity: 1; +} + +input[type=range].customizerRightItemRangeSelect::-webkit-slider-thumb { + -webkit-appearance: none; + appearance: none; + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range].customizerRightItemRangeSelect::-moz-range-thumb { + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range] { + position: absolute; + pointer-events: none; + -webkit-appearance: none; + z-index: 10002; + height: 10px; + width: 100%; + opacity: 0; +} + +input[type=range]::-webkit-slider-thumb { + pointer-events: all; + width: 30px; + height: 30px; + border-radius: 0; + border: 0 none; + background-color: red; + -webkit-appearance: none; +} + +div.CanvasXpressRangeSliderTicks, +div.CanvasXpressRangeSliderTicksLog { + display: flex; + padding: 0px 10px; + height: 18px; + margin-top: 10px; +} + +div.CanvasXpressRangeSliderTicks { + justify-content: space-between; +} + +span.CanvasXpressRangeSliderTicksLong, +span.CanvasXpressRangeSliderTicks { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + margin-bottom: 10px; +} + +span.CanvasXpressRangeSliderTicksLong { + color: var(--cx-background-color); + height: 10px; + line-height: 35px; + font-size: small; +} + +span.CanvasXpressRangeSliderTicks { + height: 5px; + line-height: 10px; +} + +/** + * Input type number + */ + +input[type=number]::-webkit-inner-spin-button { + -webkit-appearance: none; +} + +/***************/ +/* Scrollbars */ +/***************/ + +/* All scrollbar buttons*/ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-button, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-button, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-button,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-button, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-button, +div.CanvasXpressDataExplorer::-webkit-scrollbar-button, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-button, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-button, +select.CanvasXpressConfigurator::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-button, +select.CanvasXpressSlider::-webkit-scrollbar-button, +div.cX-bin-name-container::-webkit-scrollbar-button { + width: 4px; + height: 4px; +} + +/* Tracks can be of two different colors */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track, +select.CanvasXpressConfigurator::-webkit-scrollbar-track, +select.CanvasXpressSlider::-webkit-scrollbar-track { + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track, +div.cX-bin-name-container::-webkit-scrollbar-track { + background-color: rgb(245, 245, 245); +} + +/* All tracks -hovers */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track:hover, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track:hover, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track:hover,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track:hover, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track:hover, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track:hover, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressConfigurator::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track:hover, +select.CanvasXpressSlider::-webkit-scrollbar-track:hover, +div.cX-bin-name-container::-webkit-scrollbar-track:hover { + background-color: var(--cx-background-hover-color); + border-radius: 8px; +} + +/* scrollbar background could be of two different colors but match the style tracks above */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar, +select.CanvasXpressConfigurator::-webkit-scrollbar, +select.CanvasXpressSlider::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar, +div.CanvasXpressDataTableVertical::-webkit-scrollbar, +div.CanvasXpressDataExplorer::-webkit-scrollbar, +div.CanvasXpressDataCustomizer::-webkit-scrollbar, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar, +div.cX-bin-name-container::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(245, 245, 245); +} + +/* All tracks thumbs */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-thumb, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-thumb, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-thumb,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-thumb, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-thumb, +div.CanvasXpressDataExplorer::-webkit-scrollbar-thumb, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressConfigurator::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-thumb, +select.CanvasXpressSlider::-webkit-scrollbar-thumb, +div.cX-bin-name-container::-webkit-scrollbar-thumb { + background-color: var(--cx-background-contrast-color); + border-radius: 8px; + border: none; +} + +div.CanvasXpressDataFilter::selection, +div.CanvasXpressDataFilterToolbar::selection { + background: var(--cx-color-transparent); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilterContainerItem::selection { + background: var(--cx-color-transparent); + color: var(--cx-background-color); +} + +/* + * Menu + */ + +div.CanvasXpressLink { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/gif;base64,R0lGODlh+gABAIcAAOLj4/Dw8P///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAP8ALAAAAAD6AAEAAAgfAAMIHEiwoMGBAAQcXMiwocOHECNKnEixosWLGCMGBAA7); + background-repeat: repeat-y; + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-font); + line-height: 100%; + margin: 0px; + opacity: 0.95; + padding: 0px; + position: absolute; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + position: relative; +} + +input.CanvasXpressTabMenuConfigurator { + display: none; +} + +input:not(:checked).CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + display: none; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + float: left; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + float: right; + width: 100%; + margin: 22 0 0 -100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + cursor: pointer; + -moz-user-select: none; + -ms-user-select: none; + -webkit-user-select: none; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + padding: 0.5px; + border: 1px solid rgb(238, 238, 238); + border-radius: 4px; + background: rgb(255, 255, 255) +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + margin: 0; + padding: 0.5px; + overflow: hidden; + font: var(--cx-font); + color: var(--cx-font-color); + line-height: 100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + display: block; + padding: 5px; + border: 1px solid rgb(238, 238, 238); + border-bottom: none; + border-top-left-radius: 4px; + border-top-right-radius: 4px; + background: rgb(255, 255, 255) +} + +input:first-child.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + padding-left: 0; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 1; +} + +input:checked.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 2; +} + +div.CanvasXpressMenu { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 100%; + margin: 0px; + padding: 0px; + position: absolute; + opacity: 0.95; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +ul.CanvasXpressList { + background: transparent; + border: 0px none; + cursor: default; + list-style: none; + margin: 0px; + overflow: auto; + padding: 2px !important; + height: calc(100% - 100px); +} + +li.CanvasXpressListItemSep { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + height: 100%; + line-height: 1px; + list-style: none; + margin: 0px; + padding: 1px; + /* width: 100%; */ + white-space: nowrap; +} + +input.CanvasXpressListItem { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 100%; + list-style: none; + margin: 0px; + padding: 1px; + white-space: nowrap; +} + +input[type=file] { + display: block; +} + +div.CanvasXpressListItem { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; +} + +li.CanvasXpressListItem { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemActive { + background: rgba(83, 105, 255, 0.1); + border-color: rgb(83, 105, 255); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemScrollTop { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAARUlEQVR42mNkQAMXL178z0Ah0NfXZ0Tmo3BAFkhLS+M1IDw8kmHlyuV41Tx9+hTFIjiDWAtggBSLGMmxgFSLGKkRB4QAAILWJXgE49MrAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollTopActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAbUlEQVR42mNkQAOHb/38z0AhsFVjZ0Tmo3BAFmjIsOHULMLJwKDs1sFwd1cFw5vvuC258eQXikWMyBYoSOC2QIYXYgEMgCx68hm3RQ9eICxihFkgzI/bAk0xVAuQLbr+CrdFbz9CLGKkRhwQAgBYqyubRxy5uAAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottom { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAASUlEQVR42mO8ePHifwYaA0YQAbJIWloar8Lw8EgMsZUrl+PV8/TpUwZ9fX1GRpgAqRYRawHcJ6RaRIoFGJbALCIcyvgBsgUgAACiryV42XltywAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottomActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAcklEQVR42mM8fOvnfwYaA0YQAbJImJ8NpyJNMQYGZbcODPG7uyoYrr/Cbfjbj78YbNXYGRlhAiCLFCRwWyTDi2oRyIInn3Fb8OAFxAK4T5At0pDBbZEIJ8QikAVvvuO24MYThAUYlsAsIjPo4QDZAhAAAK/AK5vjVTSgAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollSearch { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 1px; + width: 100%; +} + +input.CanvasXpressListItemScrollSearch { + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 3px; + outline-style: none; + outline-width: 0px; + padding-left: 5px; + width: 93%; +} + +a.CanvasXpressListItemA { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAActive { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrow { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrowActive { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +img.CanvasXpressListIcon, +svg.CanvasXpressListIcon { + background-position: center; + border: 0px none !important; + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + height: 24px; + line-height: 24px; + list-style: none; + left: 3px; + margin: 0px !important; + padding: 0px; + position: absolute; + top: 3px; + vertical-align: top; + width: 24px; + white-space: nowrap; + background: rgba(0, 0, 0, 0) !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; +} + +span.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin-right: 10px; + white-space: nowrap; +} + +input.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + white-space: nowrap; +} + +span.CanvasXpressListItemTextShort { + color: var(--cx-font-color); + cursor: pointer; + float: right; + font: var(--cx-small-font-italic); + line-height: 24px; + list-style: none; + margin-left: 10px; + white-space: nowrap; +} + +span.CanvasXpressListItemTextSep { + background-color: rgb(224, 224, 224); + border-bottom: 1px solid; + border-bottom-color: rgb(255, 255, 255); + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + line-height: 1px; + list-style: none; + margin: 2px 3px; + overflow: hidden; + white-space: nowrap; +} + +table.CanvasXpressListItemTable { + border: collapse; + line-height: 20px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + padding-left: 3px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +img.CanvasXpressToolbarHelp, +svg.CanvasXpressToolbarHelp { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + float: right; + margin: 0px 0px 0px 2px !important; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressToolbarHelp { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border-radius: 5px; + border: 1px solid rgb(83, 105, 255); + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +p.CanvasXpressToolbarHelp { + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + margin: 0px; + padding: 5px 5px 5px 20px; +} + +div.CanvasXpressForm { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + color: var(--cx-font-color); + cursor: move; + font: var(--cx-x-large-font); + margin: 8px; + padding: 8px; + position: absolute; + white-space: nowrap; +} + +input.CanvasXpressFormButton { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mP88OHDf0aSiGfPntGaAAAL8XAJa+SuYgAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 5px 5px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormButtonActive { + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mN89fnvf0aSiBvPf9GaAABVL3D5nF6uqAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 0px 0px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormText { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + padding-left: 3px; +} + +form.CanvasXpressFormForm { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + margin: 8px; + overflow: auto; + padding-left: 3px; +} + +div.CanvasXpressConfiguratorColor { + box-sizing: content-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-font); + color: rgb(34, 34, 34); + line-height: 18px; +} + +div.CanvasXpressConfiguratorColorMain { + box-sizing: content-box; + background-image: url(data:image/png;base64,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); + background-repeat: no-repeat; + box-sizing: content-box; + border: none; + font: var(--cx-font); + color:var(--cx-font-color); + float: left; + cursor: crosshair; +} + +div.CanvasXpressConfiguratorColorExtra { + box-sizing: content-box; + background-image: url(data:image/gif;base64,R0lGODlhDwAPAKEBAAAAAP///////////yH5BAEKAAIALAAAAAAPAA8AAAIklB8Qx53b4otSUWcvyiz4/4AeQJbmKY4p1HHapBlwPL/uVRsFADs=); + background-repeat: no-repeat; + border: none; + font: var(--cx-font); + color: var(--cx-font-color); + cursor: crosshair; + overflow: hidden; +} + +/* + * Slider + */ + +div.CanvasXpressSlider { + background: rgba(0, 0, 0, 0); + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 50%; + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSliderRemote { + background: rgba(0, 0, 0, 0); + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSlider:hover { + background: rgba(0, 0, 0, 0.4); +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSlider { + width: 20px; + height: 20px; + } +} + +div.CanvasXpressSliderLeft { + left: -50px; +} + +div.CanvasXpressSliderLeft img, +div.CanvasXpressSliderLeft svg { + margin: 5px 5px 3px 3px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderLeft { + left: -25px; + } + + div.CanvasXpressSliderLeft img, + div.CanvasXpressSliderLeft svg { + margin: -4px 0px 0px -2px; + } +} + +div.CanvasXpressSliderRight { + right: -50px; +} + +div.CanvasXpressSliderRight img, +div.CanvasXpressSliderRight svg { + margin: 5px 3px 3px 8px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderRight { + right: -25px; + } + + div.CanvasXpressSliderRight img, + div.CanvasXpressSliderRight svg { + margin: -4px -2px 0px 2px; + } +} + +div.CanvasXpressSliderDotsContainer { + top: 25%; +} + +div.CanvasXpressSliderDots { + width: 10px; + height: 10px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderDots { + width: 5px; + height: 5px; + margin-left: 1px; + margin-right: 1px; + } +} + +input.CanvasXpressSlider, +select.CanvasXpressSlider { + padding: 2px 3px 2px 2px; + cursor: default; + color: var(--cx-font-color); + border-left: none; + border-right: none; + border-top: none; + border-bottom: 1px solid rgb(83, 105, 255); + background: rgba(0, 0, 0, 0); + width: 100%; + max-Width: 100%; + line-height: 22px; + margin: 0; +} + +input.CanvasXpressSlider:focus, +select.CanvasXpressSlider:focus { + outline: 0; +} + + +/* +@media (max-width: 480px) { + img { + height : 16px; + width : 16px; + } +} +*/ + + +/* + * Parent Node + */ + +div.CanvasXpress-ParentNode { + /* + border: 1px solid 'rgba(0,0,0,0)' + margin: auto; + display: table; + padding: 0; + */ + -moz-transform: none; + -webkit-transform: none; + -o-transform: none; + -ms-transform: none; + transform: none; +} + +/* + * CanvasXpress Tab Panel + */ + +div.CanvasXpressTabPanel { + font: var(--cx-x-large-font); + float: left; + width: 100% +} + +/* Customizer */ + +div.CanvasXpressTabPanelCustomizer { + position: relative; + border-bottom: 1px solid rgb(238, 238, 238); + top: -10px; + overflow: hidden; +} + +div.CanvasXpressTabPanelRibbonSection { + width: fit-content; + position: relative; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + padding-left: 8px; + padding-top: 5px; + margin-top: 12px; + float: left; +} + +span.CanvasXpressTabPanelRibbonSection { + margin-left: -3px; + background-color: white; + position: absolute; + float: left; + top: -14px; + padding: 3px; +} + +div.CanvasXpressTabPanelRibbon { + float: left; + margin-right: 10px; +} + +span.CanvasXpressTabPanelRibbon { + color: var(--cx-font-color); + font: var(--cx-x-large-font); + line-height: 28px; + list-style: none; + white-space: nowrap; + position: relative; + height: 28px; +} + +div.CanvasXpressTabPanelRibbonContainer { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +svg.CanvasXpressTabPanelRibbon { + float: left; + border: 1px solid rgb(83, 105, 255); + margin-left: 5px; + margin-top: 5px; + padding: 2px; + border-radius: 5px; + background-color: rgb(255, 255, 255); +} + +svg.CanvasXpressTabPanelRibbon:hover { + background: rgba(83, 105, 255, 0.1) +} + +/* Header */ + +div.CanvasXpressTabPanelHeader { + font: var(--cx-x-large-font); + border-bottom: 2px solid rgb(83, 105, 255); + height: 38px; + width: 100%; + float: left; +} + +div.CanvasXpressTabPanelHeaderTab { + font: var(--cx-x-large-font); + margin-left: 20px; + margin-right: 20px; + float: left; +} + +input.CanvasXpressTabPanelHeader { + border-width: 1px 1px 0 1px; + border-color: rgb(83, 105, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +input.CanvasXpressTabPanelHeaderActive { + border-bottom-width: 2px; + border-left-color: rgb(83, 105, 255); + border-top-color: rgb(83, 105, 255); + border-right-color: rgb(83, 105, 255); + border-bottom-color: rgb(255, 255, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +/* Content */ + +div.CanvasXpressTabPanelContent { + display: block; + float: left; + width: 100%; + position: relative; +} + +/* Rows */ + +div.CanvasXpressRow { + clear: both; + display: flex; + flex-wrap: wrap; + float: left; + width: 100%; +} + +div.CanvasXpressRow:before, +div.CanvasXpressRow:after { + content: " "; + display: table; +} + +div.CanvasXpressRow:after { + clear: both; +} + +div.CanvasXpressRowColumnFull, +div.CanvasXpressRowColumnTwoThird, +div.CanvasXpressRowColumnThreeFourth, +div.CanvasXpressRowColumnFourFifth, +div.CanvasXpressRowColumnFiveSixth, +div.CanvasXpressRowColumnHalf, +div.CanvasXpressRowColumnThird, +div.CanvasXpressRowColumnFourth, +div.CanvasXpressRowColumnFifth, +div.CanvasXpressRowColumnSixth { + float: left; + /* + padding-left: 1rem; + padding-right: 1rem; + */ + -moz-box-sizing: border-box; + -webkit-box-sizing: border-box; + box-sizing: border-box; +} + +div.CanvasXpressRowColumnFull:hover, +div.CanvasXpressRowColumnTwoThird:hover, +div.CanvasXpressRowColumnThreeFourth:hover, +div.CanvasXpressRowColumnFourFifth:hover, +div.CanvasXpressRowColumnFiveSixth:hover, +div.CanvasXpressRowColumnHalf:hover, +div.CanvasXpressRowColumnThird:hover, +div.CanvasXpressRowColumnFourth:hover, +div.CanvasXpressRowColumnFifth:hover, +div.CanvasXpressRowColumnSixth:hover { + border: 1px dashed rgb(238, 238, 238); +} + +div.CanvasXpressRowColumnFull { + border: 1px dashed white; + width: 100%; +} + +div.CanvasXpressRowColumnFullActive { + border: 1px dashed rgb(83, 105, 255); + width: 100%; +} + +div.CanvasXpressRowColumnTwoThird { + border: 1px dashed white; + width: 66.7%; +} + +div.CanvasXpressRowColumnTwoThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 66.7%; +} + +div.CanvasXpressRowColumnThreeFourth { + border: 1px dashed white; + width: 75%; +} + +div.CanvasXpressRowColumnThreeFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 75%; +} + +div.CanvasXpressRowColumnFourFifth { + border: 1px dashed white; + width: 80%; +} + +div.CanvasXpressRowColumnFourFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 80%; +} + +div.CanvasXpressRowColumnFiveSixth { + border: 1px dashed white; + width: 83.4%; +} + +div.CanvasXpressRowColumnFiveSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 83.4%; +} + +div.CanvasXpressRowColumnHalf { + border: 1px dashed white; + width: 50%; +} + +div.CanvasXpressRowColumnHalfActive { + border: 1px dashed rgb(83, 105, 255); + width: 50%; +} + +div.CanvasXpressRowColumnThird { + border: 1px dashed white; + width: 33.3%; +} + +div.CanvasXpressRowColumnThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 33.3%; +} + +div.CanvasXpressRowColumnFourth { + border: 1px dashed white; + width: 25%; +} + +div.CanvasXpressRowColumnFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 25%; +} + +div.CanvasXpressRowColumnFifth { + border: 1px dashed white; + width: 20%; +} + +div.CanvasXpressRowColumnFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 20%; +} + +div.CanvasXpressRowColumnSixth { + border: 1px dashed white; + width: 16.6%; +} + +div.CanvasXpressRowColumnSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 16.6%; +} + +/* + * CanvasXpress + */ + +canvas.CanvasXpress { + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + user-select: none; + -ms-user-select: none; +} + +canvas.CanvasXpress:hover { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; +} + +canvas.CanvasXpressUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,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'); + background-size: contain; + background-repeat: no-repeat; +} + +canvas.CanvasXpress::selection { + background: rgba(0, 0, 0, 0); + color: rgb(0, 0, 0); +} + +div.CanvasXpressPlay { + background-color: rgba(0, 0, 0, 0.05); + background-image: url('data:image/png;base64,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'); + background-position-x: 50%; + background-position-y: center; + background-size: 25%; + background-repeat: no-repeat; + position: absolute; +} + +div.CanvasXpressPlay:hover { + background-color: rgba(0, 0, 0, 0); +} + +div.CanvasXpressContainer { + box-sizing: border-box; + position: relative; + float: left; +} + +div.CanvasXpressWrapper { + box-sizing: border-box; + position: relative; + float: left; + line-height: 100%; +} + +/* + * full-screen-warning-container + */ + +#full-screen-warning-container { + background-color: transparent !important; + opacity: 0.4 !important; +} + +#full-screen-warning-container[fade-warning-out] { + transition-property: opacity !important; + transition-duration: 1ms !important; + opacity: 0.0 !important; +} + +#full-screen-warning-message { + padding: 15px !important; +} + +.full-screen-description { + font-size: 100% !important; +} + +#full-screen-domain-text { + font-size: 100% !important; + font-weight: bold !important; +} + +.full-screen-approval-button, +#full-screen-remember-decision { + font-size: 100% !important; +} + +@media (min-width: 300px) { + div.cX-bin { + transform: scale(0.5); + } +} + +@media (min-width: 450px) { + div.cX-bin { + transform: scale(0.75); + } +} + +@media (min-width: 600px) { + div.cX-bin { + transform: scale(1); + } +} + + +/* Genie Effect */ + +.genie { + position: relative; + background-repeat: no-repeat; + background-size: cover; +} + +.genie .genie-step { + background-repeat: no-repeat; + background-image: inherit; + position: absolute; +} + +.genie.genie-expand .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-collapse .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +.genie.genie-collapse.change-pace .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-expand.change-pace .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +/* Hide Efect */ + +.appear { + transition: all 1s linear; + opacity: 1; +} + +.dissapear { + display: none; +} + +.dissapearHidden { + transition: all 1s linear; + opacity: 0; +} + +/* Magic Effects */ + + +/* +Magic - Ver 1.3.0 - https://minimamente.com +Licensed under the MIT license +Copyright (c) 2018 Christian Pucci +*/ + +.magictime { + -webkit-animation-duration: 1s; + animation-duration: 1s; + -webkit-animation-fill-mode: both; + animation-fill-mode: both; +} + +.showIn { + -webkit-animation-name: showIn; + animation-name: showIn; +} + +@-webkit-keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +@keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +.showOut { + -webkit-animation-name: showOut; + animation-name: showOut; +} + +@-webkit-keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +@keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +.puffIn { + -webkit-animation-name: puffIn; + animation-name: puffIn; +} + +@-webkit-keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.puffOut { + -webkit-animation-name: puffOut; + animation-name: puffOut; +} + +@-webkit-keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +@keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +.vanishIn { + -webkit-animation-name: vanishIn; + animation-name: vanishIn; +} + +@-webkit-keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.vanishOut { + -webkit-animation-name: vanishOut; + animation-name: vanishOut; +} + +@-webkit-keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.boingInUp { + -webkit-animation-name: boingInUp; + animation-name: boingInUp; +} + +@-webkit-keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.boingOutDown { + -webkit-animation-name: boingOutDown; + animation-name: boingOutDown; +} + +@-webkit-keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +@keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +.foolishIn { + -webkit-animation-name: foolishIn; + animation-name: foolishIn; +} + +@-webkit-keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +@keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +.foolishOut { + -webkit-animation-name: foolishOut; + animation-name: foolishOut; +} + +@-webkit-keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +@keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +.holeIn { + -webkit-animation-name: holeIn; + animation-name: holeIn; +} + +@-webkit-keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +@keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +.holeOut { + -webkit-animation-name: holeOut; + animation-name: holeOut; +} + +@-webkit-keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +@keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +.swashIn { + -webkit-animation-name: swashIn; + animation-name: swashIn; +} + +@-webkit-keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +@keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +.swashOut { + -webkit-animation-name: swashOut; + animation-name: swashOut; +} + +@-webkit-keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +@keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +.bombLeftOut { + -webkit-animation-name: bombLeftOut; + animation-name: bombLeftOut; +} + +@-webkit-keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.bombRightOut { + -webkit-animation-name: bombRightOut; + animation-name: bombRightOut; +} + +@-webkit-keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.magic { + -webkit-animation-name: magic; + animation-name: magic; +} + +@-webkit-keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +@keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +.swap { + -webkit-animation-name: swap; + animation-name: swap; +} + +@-webkit-keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +@keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +.twisterInDown { + -webkit-animation-name: twisterInDown; + animation-name: twisterInDown; +} + +@-webkit-keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +@keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +.twisterInUp { + -webkit-animation-name: twisterInUp; + animation-name: twisterInUp; +} + +@-webkit-keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +@keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +.spaceInDown { + -webkit-animation-name: spaceInDown; + animation-name: spaceInDown; +} + +@-webkit-keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInLeft { + -webkit-animation-name: spaceInLeft; + animation-name: spaceInLeft; +} + +@-webkit-keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInRight { + -webkit-animation-name: spaceInRight; + animation-name: spaceInRight; +} + +@-webkit-keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInUp { + -webkit-animation-name: spaceInUp; + animation-name: spaceInUp; +} + +@-webkit-keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceOutDown { + -webkit-animation-name: spaceOutDown; + animation-name: spaceOutDown; +} + +@-webkit-keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +@keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +.spaceOutLeft { + -webkit-animation-name: spaceOutLeft; + animation-name: spaceOutLeft; +} + +@-webkit-keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +@keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +.spaceOutRight { + -webkit-animation-name: spaceOutRight; + animation-name: spaceOutRight; +} + +@-webkit-keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +@keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +.spaceOutUp { + -webkit-animation-name: spaceOutUp; + animation-name: spaceOutUp; +} + +@-webkit-keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +@keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +.perspectiveDown { + -webkit-animation-name: perspectiveDown; + animation-name: perspectiveDown; +} + +@-webkit-keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +@keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +.perspectiveDownReturn { + -webkit-animation-name: perspectiveDownReturn; + animation-name: perspectiveDownReturn; +} + +@-webkit-keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.perspectiveLeft { + -webkit-animation-name: perspectiveLeft; + animation-name: perspectiveLeft; +} + +@-webkit-keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +@keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +.perspectiveLeftReturn { + -webkit-animation-name: perspectiveLeftReturn; + animation-name: perspectiveLeftReturn; +} + +@-webkit-keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveRight { + -webkit-animation-name: perspectiveRight; + animation-name: perspectiveRight; +} + +@-webkit-keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +@keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +.perspectiveRightReturn { + -webkit-animation-name: perspectiveRightReturn; + animation-name: perspectiveRightReturn; +} + +@-webkit-keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveUp { + -webkit-animation-name: perspectiveUp; + animation-name: perspectiveUp; +} + +@-webkit-keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +@keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +.perspectiveUpReturn { + -webkit-animation-name: perspectiveUpReturn; + animation-name: perspectiveUpReturn; +} + +@-webkit-keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.rotateDown { + -webkit-animation-name: rotateDown; + animation-name: rotateDown; +} + +@-webkit-keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +@keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +.rotateLeft { + -webkit-animation-name: rotateLeft; + animation-name: rotateLeft; +} + +@-webkit-keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +@keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +.rotateRight { + -webkit-animation-name: rotateRight; + animation-name: rotateRight; +} + +@-webkit-keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +@keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +.rotateUp { + -webkit-animation-name: rotateUp; + animation-name: rotateUp; +} + +@-webkit-keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +@keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +.slideDown { + -webkit-animation-name: slideDown; + animation-name: slideDown; +} + +@-webkit-keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown2 { + -webkit-animation-name: slideDown2; + animation-name: slideDown2; +} + +@-webkit-keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown3 { + -webkit-animation-name: slideDown3; + animation-name: slideDown3; +} + +@-webkit-keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDownReturn { + -webkit-animation-name: slideDownReturn; + animation-name: slideDownReturn; +} + +@-webkit-keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideDownReturn2 { + -webkit-animation-name: slideDownReturn2; + animation-name: slideDownReturn2; +} + +@-webkit-keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideLeft { + -webkit-animation-name: slideLeft; + animation-name: slideLeft; +} + +@-webkit-keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +@keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +.slideLeftReturn { + -webkit-animation-name: slideLeftReturn; + animation-name: slideLeftReturn; +} + +@-webkit-keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideLeftReturn2 { + -webkit-animation-name: slideLeftReturn2; + animation-name: slideLeftReturn2; +} + +@-webkit-keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideRight { + -webkit-animation-name: slideRight; + animation-name: slideRight; +} + +@-webkit-keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +@keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +.slideRightReturn { + -webkit-animation-name: slideRightReturn; + animation-name: slideRightReturn; +} + +@-webkit-keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideUp { + -webkit-animation-name: slideUp; + animation-name: slideUp; +} + +@-webkit-keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUp2 { + -webkit-animation-name: slideUp2; + animation-name: slideUp2; +} + +@-webkit-keyframes slideUp2 { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp2 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUpReturn { + -webkit-animation-name: slideUpReturn; + animation-name: slideUpReturn; +} + +@-webkit-keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideUpReturn2 { + -webkit-animation-name: slideUpReturn2; + animation-name: slideUpReturn2; +} + +@-webkit-keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.openDownLeft { + -webkit-animation-name: openDownLeft; + animation-name: openDownLeft; +} + +@-webkit-keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownLeftReturn { + -webkit-animation-name: openDownLeftReturn; + animation-name: openDownLeftReturn; +} + +@-webkit-keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownRight { + -webkit-animation-name: openDownRight; + animation-name: openDownRight; +} + +@-webkit-keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightReturn { + -webkit-animation-name: openDownRightReturn; + animation-name: openDownRightReturn; +} + +@-webkit-keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpLeft { + -webkit-animation-name: openUpLeft; + animation-name: openUpLeft; +} + +@-webkit-keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftReturn { + -webkit-animation-name: openUpLeftReturn; + animation-name: openUpLeftReturn; +} + +@-webkit-keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpRight { + -webkit-animation-name: openUpRight; + animation-name: openUpRight; +} + +@-webkit-keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightReturn { + -webkit-animation-name: openUpRightReturn; + animation-name: openUpRightReturn; +} + +@-webkit-keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownLeftOut { + -webkit-animation-name: openDownLeftOut; + animation-name: openDownLeftOut; +} + +@-webkit-keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightOut { + -webkit-animation-name: openDownRightOut; + animation-name: openDownRightOut; +} + +@-webkit-keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftOut { + -webkit-animation-name: openUpLeftOut; + animation-name: openUpLeftOut; +} + +@-webkit-keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightOut { + -webkit-animation-name: openUpRightOut; + animation-name: openUpRightOut; +} + +@-webkit-keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.tinDownIn { + -webkit-animation-name: tinDownIn; + animation-name: tinDownIn; +} + +@-webkit-keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinDownOut { + -webkit-animation-name: tinDownOut; + animation-name: tinDownOut; +} + +@-webkit-keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +@keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +.tinLeftIn { + -webkit-animation-name: tinLeftIn; + animation-name: tinLeftIn; +} + +@-webkit-keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinLeftOut { + -webkit-animation-name: tinLeftOut; + animation-name: tinLeftOut; +} + +@-webkit-keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +@keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +.tinRightIn { + -webkit-animation-name: tinRightIn; + animation-name: tinRightIn; +} + +@-webkit-keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinRightOut { + -webkit-animation-name: tinRightOut; + animation-name: tinRightOut; +} + +@-webkit-keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +@keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +.tinUpIn { + -webkit-animation-name: tinUpIn; + animation-name: tinUpIn; +} + +@-webkit-keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinUpOut { + -webkit-animation-name: tinUpOut; + animation-name: tinUpOut; +} + +@-webkit-keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +@keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +.blink { + -webkit-animation-name: blink; + animation-name: blink; +} + +@-webkit-keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} + +@keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} \ No newline at end of file diff --git a/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.min.js b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.min.js new file mode 100644 index 00000000..bef6f562 --- /dev/null +++ b/docs/articles/dbparser_files/canvasXpress-58.7/canvasXpress.min.js @@ -0,0 +1,303 @@ +/** + * + * CanvasXpress 58.7 - JavaScript Canvas Library + * + * Copyright (c) 2009-2025 - license@canvasxpress.org + * + * Redistributions of the source code must retain this copyright + * notice and the following disclaimer. + * + * CanvasXpress is released as open source for personal and + * educational use with dual licensing for commercial purposes. + * + * This program is distributed in the hope that it will be useful, + * but WITHOUT ANY WARRANTY; without even the implied warranty of + * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. + * + * Please see a copy of the CanvasXpress License at + * https://www.canvasxpress.org/docs/license.html. + * + * Dual licensing: + * Commercial use may be granted to the extent that this source + * code does NOT become part of any other Open Source or + * Commercially licensed development library or toolkit without + * explicit permission from CanvasXpress. + * + */ +/** + * + * sprintf() for JavaScript v.0.4 + * + * Copyright (c) 2007 Alexandru Marasteanu + * Thanks to David Baird (unit test and patch). + * + * This program is free software; you can redistribute it and/or modify it under + * the terms of the GNU General Public License as published by the Free Software + * Foundation; either version 2 of the License, or (at your option) any later + * version. + * + * This program is distributed in the hope that it will be useful, but WITHOUT + * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS + * FOR A PARTICULAR PURPOSE. See the GNU General Public License for more + * details. + * + * You should have received a copy of the GNU General Public License along with + * this program; if not, write to the Free Software Foundation, Inc., 59 Temple + * Place, Suite 330, Boston, MA 02111-1307 USA + * + *** + * + * Date Format 1.2.3 + * (c) 2007-2009 Steven Levithan + * MIT license + * + * Includes enhancements by Scott Trenda + * and Kris Kowal + * + * Accepts a date, a mask, or a date and a mask. + * Returns a formatted version of the given date. + * The date defaults to the current date/time. + * The mask defaults to dateFormat.masks.default. + * + **** + * + * jLouvain.js + * Author: Corneliu S. (github.com/upphiminn) + * This is a javascript implementation of the Louvain + * community detection algorithm (http://arxiv.org/abs/0803.0476) + * Based on https://bitbucket.org/taynaud/python-louvain/overview + * + **** + * + * science.js + * Copyright (c) 2011, Jason Davies + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * The name Jason Davies may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND + * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED + * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE + * DISCLAIMED. IN NO EVENT SHALL JASON DAVIES BE LIABLE FOR ANY DIRECT, INDIRECT, + * INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT + * LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR + * PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF + * LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE + * OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF + * ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * Apache-Style Software License for ColorBrewer software and ColorBrewer Color + * Schemes + * + * Copyright (c) 2002 Cynthia Brewer, Mark Harrower, and The Pennsylvania State + * University. + * + * Licensed under the Apache License, Version 2.0 (the "License"); you may not + * use this file except in compliance with the License. You may obtain a copy of + * the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, WITHOUT + * WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the + * License for the specific language governing permissions and limitations under + * the License. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * 1. Redistributions as source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * 2. The end-user documentation included with the redistribution, if any, must + * include the following acknowledgment: "This product includes color + * specifications and designs developed by Cynthia Brewer + * (http://colorbrewer.org/)." Alternately, this acknowledgment may appear in the + * software itself, if and wherever such third-party acknowledgments normally + * appear. + * + * 4. The name "ColorBrewer" must not be used to endorse or promote products + * derived from this software without prior written permission. For written + * permission, please contact Cynthia Brewer at cbrewer@psu.edu. + * + * 5. Products derived from this software may not be called "ColorBrewer", nor + * may "ColorBrewer" appear in their name, without prior written permission of + * Cynthia Brewer. + * + **** + * + * FileSaver.js + * Copyright © 2015 [Eli Grey][1]. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * canvas-toBlob.js + * Copyright © 2011 Eli Grey and Devin Samarin. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * Blob.js + * Copyright © 2014 Eli Grey. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * jstat.js + * Copyright (c) 2013 jStat + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * numeric.js + * Numeric Javascript + * Copyright (C) 2011 by Sébastien Loisel + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * Sankey.js + * Copyright (c) 2012, Michael Bostock + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * * The name Michael Bostock may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" + * AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE + * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE + * ARE DISCLAIMED. IN NO EVENT SHALL MICHAEL BOSTOCK BE LIABLE FOR ANY DIRECT, + * INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES + * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; + * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND + * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT + * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS + * SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * canvas2svg + * The MIT License (MIT) + * + * Copyright (c) 2014 Gliffy Inc. + * + * Permission is hereby granted, free of charge, to any person obtaining a copy of + * this software and associated documentation files (the "Software"), to deal in + * the Software without restriction, including without limitation the rights to + * use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of + * the Software, and to permit persons to whom the Software is furnished to do so, + * subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS + * FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR + * COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER + * IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + * CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + */ +(function(b,a){if(typeof exports==="object"){a(exports)}else{(a((b.CanvasXpress=b.CanvasXpress||{})))}}(this,(function(){CanvasXpress=typeof CanvasXpress!="undefined"&&CanvasXpress.ready?CanvasXpress:function(n,h,e,s,d,p,r,l){var k=this;var q=function(){k.init(n,h,e,s,d,p,r,l)};var c=function(i){if(i){k.init(i);if(r){r(i)}}else{k.init(n,h,e,s,d,p,r,l)}};var j=document.styleSheets;var b=false;for(var g=0;g-1){b=true;break}}if(e&&typeof e=="string"){e={prompt:e,llmBehaviour:"update",view:"table"}}else{if(n&&n.config&&n.config.prompt&&n.config.isR){n.config.llmBehaviour="update";n.config.view="table"}}if(!b){var 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provided")}else{if(typeof(f)=="object"&&f.renderTo){d=f.tracks?{tracks:f.tracks}:f.nodes?{nodes:f.nodes}:f.venn?{venn:f.venn}:f.data?f.data:false;b=f.config||false;if(f.version){b.createVersion=f.version}if(f.factory){b.createFactory=f.factory}c=f.events||false;e=f.info?f.info.replace(/'/g,"'").replace(/"/g,"'"):false;h=f.afterRender||false;g=f.callback||false;a=f.noValidate?f.noValidate:b&&b.noValidate?b.noValidate:false;f=f.renderTo;CanvasXpress.inject(f)}else{if(typeof f==="string"||f instanceof String){CanvasXpress.inject(f)}}}return{target:f,data:d,config:b,events:c,info:e,afterRender:h,callback:g,noValidate:a}};CanvasXpress.inject=function(c){if(typeof c==="string"||c instanceof String){var b=document.getElementById(c);if(b!==null){if(b.tagName.toLowerCase()=="canvas"){if(!b.width){b.width=500}if(!b.height){b.height=500}}else{if(b.tagName.toLowerCase()=="div"){b.id=c+"-div";var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;b.appendChild(a)}}}else{var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;document.body.appendChild(a)}}};CanvasXpress.loadFonts=function(d,c){if(d&&d.length&&c){var b=false;for(var a=0;a: "+k.parameters[l]+"

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z=document.createElement("div");z.style.width=w+"px";z.style.height="100px";z.style.clear="both";z.style.position="relative";z.style.margin="auto";var n=document.createElement("span");n.innerHTML=a.datetime;n.style.cssFloat="right";var d=document.createElement("span");d.innerHTML=a.prompt;d.style.cssFloat="left";d.style.fontWeight="bold";var y=document.createElement("span");y.innerHTML=a.client;y.style.cssFloat="left";var x=document.createElement("br");var v=document.createElement("br");var h=document.createElement("br");z.appendChild(x);z.appendChild(y);z.appendChild(n);z.appendChild(v);z.appendChild(d);z.appendChild(h);return z};var e=function(h,d){var n=document.createElement("div");if(d){n.className=d}n.appendChild(h);return n};var j=function(w,h){var x=CanvasXpress.parametersLLM;h.CZ();var n=h.meta.config.user;var d={graphOrientation:true,graphType:true,isR:true,prompt:true};for(var v=0;v=0){that.rY([vi,x,y]);draw=true}if(si>=0){that.rY([that.varIndices[0],si]);draw=true}}if(draw){that.z4()}}};var isPWC=function(){for(var i=0;i0?ar.shift():[];var cn=ar.length>0?ar.shift():{};var tm=ar.length>0?ar.shift():t;var rp=ar.length>0?ar.shift():false;if(this.view=="table"&&fn=="setDimensions"){continue}if(fn=="setDimensions"){if(this.width==pr[0]&&this.height==pr[1]){continue}}if(fn=="clickView"){cv=true;continue}if(fn=="updateDataFilter"||fn=="resetDataFilter"){this.skipRender=true}var dr=arr[i+1]&&arr[i+1][0]&&arr[i+1][0].match(/drag/i)?true:false;this.skipRender=fn=="createDOE"||fn=="createHistogram"||fn=="modifyColorScheme"||fn.match(/segregate/)||dr?false:!this.showTransition&&i0&&!CanvasXpress.readyFonts){CanvasXpress.readyFonts=true;return}t.fo("canvasXpress data ready - 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t=this;t.wu(o);t.GW("init");t.T4();t.gh(o);t.uU();t.Ki();t.Vd();t.YX();t.uo(o.config);t.y8();t.Pw();t.CI();t.jY(o.data);t.GW("initData");t.sb();t.EP();t.fR();t.zA();t.sw(o.data,o.config,o.events,o.info,o.afterRender);t.wE();t.Ki();t.c9(o.callback)};this.uY(o)};CanvasXpress.prototype.initStart=function(){this.initIO();this.initCrypt();this.initDOM();this.initViewport();this.initConfig()};CanvasXpress.prototype.initDataset=function(){this.yi=function(){delete (this.meta.data);this.cN(false,false,false,true)};this.af=function(c){if(c){this.meta.data={tracks:[]}}for(var H=0;HF){F=g;K=x[B].length;u=x[B]}}var e=[];for(var B=0;BI){I=h;O=B[H].length;A=B[H]}}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A;c.colors=[];var p=0;for(var H=0;HI){I=h;O=c.levels[H].toString().length;A=c.levels[H]}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A}c.shapes=this.shapes;c.sizes=this.sizes;c.patterns=this.patterns}P[E][G]=c}}}}if(this.decorations.length&&this.decorationsType=="heatmap"){var u=[];P.decorations={};P.decorations.unique=false;P.decorations.type="Numeric";P.decorations.n=0;for(var H=0;HI){I=h;O=P.decorations.levels[H].toString().length;A=P.decorations.levels[H]}P.decorations.maxLevLen=I;P.decorations.maxLevChr=O;P.decorations.maxLevStr=A}}}};this.FV=function(O,af,ac,P,ah){var J=this;var G=this.meta.config.user;var A=this.meta.data;var l=this.data;var C=CanvasXpress.colorSchemes;var p=["x","z","w"];var Y=this.font;var D=function(s,a,r,ai,al,ak){var t={};if(J.legendOrder&&J.legendOrder[s]){for(var aj=0;ajr[r.length-1]){t--;while(!C[J[ai+"Key"][U]][t]){t--}}else{if(td.length&&d.length==1&&J.graphType=="Map"){var t=S.length;var r=J.p4(C[J.colorScheme]);r.sort(function(aj,j){return aj-j});if(t>r[r.length-1]){t--;while(!C[J.colorScheme][t]){t--}}else{if(t10?d.colorBrew.vals:aj;d.order={};for(var s=0;sag){ag=t;c=d.levels[s].toString().length;aa=d.levels[s]}d.maxLevLen=ag;d.maxLevChr=c;d.maxLevStr=aa}}else{d[a+"s"]=a=="connect"?J.colors:J[a+"s"]}};if(!O||O=="w"||O=="x"||O=="z"){if(O&&ac){if(!af){delete (A[O])}else{if(A[O][af]){delete (A[O][af])}}}for(var X=0;Xag){ag=E;c=S[V].length;aa=S[V]}}I.maxLevLen=ag;I.maxLevChr=c;I.maxLevStr=aa;Z("color",this.colors,I);Z("shape",this.shapes,I);Z("size",this.Pk(S.length),I);Z("pattern",this.patterns,I);Z("linePattern",this.linePatterns,I);Z("connect",this.colors,I)}else{I.unique=false;I["boolean"]=false;for(var V=0;VA.m[T].maxFacLen){A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}else{A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}}if(P){return}var w,H,R;if(T=="z"){w="y";H="vars";R="Var"}if(T=="x"||T=="q"){w="y";H="smps";R="Smp"}if(T=="w"){w="w";H="smps";R="Smp"}var ag=0;var c=0;var aa="";if(l[w]){for(var V=0;Vthis.fullTextMeasureCheck){var L=l[w][H][V].toString().length;if(L>c){var E=this.HR(l[w][H][V],Y);if(E>ag){ag=E;c=L;aa=l[w][H][V]}}}else{if(l[w][H][V]!=null){var L=l[w][H][V].toString().length;if(L>=c){var E=this.HR(l[w][H][V].toString(),Y);if(E>ag){ag=E;c=L;aa=l[w][H][V].toString()}}}}}A[w]["max"+R+"Len"]=ag;A[w]["max"+R+"Chr"]=c;A[w]["max"+R+"Str"]=aa;A[w].vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";A[w].smps=this.nn(l.y.smps)?"World":this.RX(l.y.smps)?"USA":this.Ng(l.y.smps,true)?"Date":"String";if(A[w].smps=="Date"){A[w].date=this.vy(l.y.smps)}if(T=="x"){var ab={};var z=l.y.smps;for(var V=0;Vthis.fullTextMeasureCheck){var L=l.y.vars[V].toString().length;if(L>c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}else{if(l.y.vars[V]!=null){var L=l.y.vars[V].toString().length;if(L>=c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}}}A.y.maxVarLen=ag;A.y.maxVarChr=c;A.y.maxVarStr=aa;A.y.vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";if(!A.y.range){A.y.range={}}for(var V=0;Vag){ag=E;c=A[O].levels[V].toString().length;aa=A[O].levels[V]}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa}A[O].shapes=this.shapes;A[O].sizes=this.sizes;A[O].patterns=this.patterns}else{var S={};for(var V=0;Vag){ag=E;c=S[V].length;aa=S[V]}}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa;A[O].type="String";A[O].colors=[];var K=0;for(var V=0;V0){return true}else{if(a=="max"&&b.max&&b.max[0].length>0){return true}else{if(a=="min"&&b.min&&b.min[0].length>0){return true}else{if(a=="count"&&b.count&&b.count[0].length>0){return true}else{if(a=="mean"&&b.mean&&b.mean[0].length>0){return true}else{if(a=="median"&&b.median&&b.median[0].length>0){return true}else{if(a=="iqr"&&b.iqr1&&b.qtl1&&b.median&&b.qtl3&&b.iqr3&&b.median[0].length>0){return true}else{if(a=="raw"&&this.isRawData){return true}else{return false}}}}}}}}}}}}};this.we=function(aw,f,Q,ag,J){var W=this;var r=this.isDOE?this.data.l.data[this.layoutCurrent||0]:false;var t=this.isGroupedData&&!f&&this.data.w?this.data.w:this.data.y;var ah=this.graphType=="Scatter2D"&&this.scatterType=="visium"?CanvasXpress.cacheImages[this.backgroundImageMD5||this.va(this.backgroundImage)]:false;var w=this.Xs(true);var at=Number.POSITIVE_INFINITY;var K=Number.NEGATIVE_INFINITY;var A=Number.POSITIVE_INFINITY;var ab=Number.NEGATIVE_INFINITY;if(this.setMin!=null&&this.setMax!=null){this.minData=Number(this.setMin);this.maxData=Number(this.setMax);return}if(this.isGroupedData&&!aw&&!r){aw=this.graphType=="Boxplot"?"iqr":this.summaryType;if(this.graphType=="Boxplot"&&!this.isBoxplotCalc){this.cg(this.groupingFactors,false,false,false,true);t=this.data.w}}if(this.isGroupedData&&!f&&this.data.w&&!ag&&!r&&!this.layoutCurrent){for(var ak=0;ak=0?H:0;var Y=this.data.y.data[this.meterIndex];at=0;K=this.ob(Y,true)}else{if(w){var G=this.varIndices.length;for(var ak=0;ak=0){var ad=this.Ts(this.data.y.data[ap]);at=ad[0];K=ad[1]}else{at=0;K=1}}}else{if(aw=="gantt"){if(!this.data.gantt){this.isGanttDataFormated=false;this.ww()}var ak=this.as(this.ganttStart?this.ganttStart:this.xAxis[0]?this.xAxis[0]:this.data.y.vars[0]);this.ganttStart=this.data.y.vars[ak];var aj=this.as(this.ganttEnd?this.ganttEnd:this.xAxis[1]?this.xAxis[1]:this.data.y.vars[1]?this.data.y.vars[1]:this.data.y.vars[0]);this.ganttEnd=this.data.y.vars[aj]||this.data.y.vars[0];var ar=this.i4(this.data.gantt);at=ar[ak].sort(function(d,c){return d-c})[0];K=ar[aj].sort(function(d,c){return c-d})[0]}else{if(aw=="km"&&!f){if(!this.layoutValid){this.DO()}if(J=="y"){at=0;K=1}else{var ac=this.layoutValid&&this.meta.data.p.l.length?this.meta.data.p.l:this.meta.data.p.g;if(this.layoutValid&&this.meta.data.p.l.length){for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}}else{var G=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0){at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{if(Q){if(O>0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}}}}else{if(this.summaryType=="mean"&&!this.isRawData){var S=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0&&B>0){at=Math.min(D,at);K=Math.max(B,K)}}else{at=Math.min(D,at);K=Math.max(B,K)}}if(X){var T=X.length;for(var ai=0;ai0){at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}else{at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}}}}}}}else{if(aw=="cor"){var o=this.correlationAxis=="variables"?this.varIndices:this.isGroupedData?this.grpIndices:this.smpIndices;var S=o.length;for(var ak=0;ak0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}else{if(r){var C=J=="xAxis"?0:1;if(this.graphType=="Scatter2D"){for(var ak=0;ak0){if(ag){var V=this.graphType=="Circular"&&this.showIdeogram;var F=V?[this.varIndices,this.smpIndices]:[this.smpIndices,this.varIndices];var y=F[0].length;K=0;at=0;ab=0;A=0;for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}else{var S=this.motionBy||(this.isDOE&&this.isDOE==1)?this.data.y.vars.length:this.varIndices.length;for(var 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aa=this.layoutValid?this.meta.data.s.layout[this.layoutCurrent||0]:this.meta.data.s;switch(this.scatterStreamType){case"mirror":at=-aa.maxY;K=aa.maxY;break;case"ridge":at=0;K=aa.maxY*2;break;case"proportional":at=0;K=1;break}}}}}else{if(this.graphType=="Scatter2D"&&J=="yAxis"&&(this.showLoessFit||this.showRegressionFit||this.showQuantileRegressionFit)){if(this.showLoessFit){this.l1()}if(this.showRegressionFit){this.ba()}if(this.showQuantileRegressionFit){this.Tw()}if(this.meta.data.s){var af=this.meta.data.s;if(af.minY!=null&&af.minYNumber.NEGATIVE_INFINITY){if(this.dataPointSizeScaleFactor){at=Math.min(at,af.minY);K=Math.max(K,af.maxY)}else{at=af.minY;K=af.maxY}}}}}}}}}}if(this.decorations){if(this.decorations.error){for(var ak=0;ak=f&&d<=b))&&(e===null||(c>=e&&c<=a))){}else{if(q){this.filterFitIndices[q[h]]=true}else{this.filterFitIndices[r]=true}}}}for(var h=0;h=f&&d<=b))&&(e===null||(c>=e&&c<=a))){j.push(d);g.push(c)}}return[j,g]};this.WL=function(){var I=this;var K=[];var 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ap=I.data;if(!Z.hasOwnProperty("Factor")){Z.Factor={}}var ai=0;for(var am=0;amthis.maxDOENumber){break}}}else{for(var T=0;Tthis.maxDOENumber){break}}}o=true}}}else{if(this.graphType.match(/Scatter|Map/)){if(this.segregateVariablesBy.length&&this.meta.data.z&&this.meta.data.z.hasOwnProperty(this.segregateVariablesBy[0])){var Z=I.meta.data.s.density;var V=A(0);if(this.segregateVariablesBy.length==2||(this.showHistogram!=true&&this.showHistogram!=this.segregateVariablesBy[0])){var e=this.segregateVariablesBy.length==2?this.segregateVariablesBy[1]:this.showHistogram;var U=this.segregateVariablesBy.length==2?A(1):A(false,e);K=[];var h=this.meta.data.z[this.segregateVariablesBy[0]].levels;var f=this.meta.data.z[e].levels;var X=this.data;var N=0;for(var T=0;T5){try{b.loess[o+":"+h[d]]=this.Ed([q[0],q[1]],"Loess:"+o+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.loess[o+":"+h[d]].range[3])}catch(c){f.push(["setLoessData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.loess[o]=this.Ed([q[0],q[1]],"Global:"+o+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o].range[2]);b.maxY=Math.max(b.maxY,b.loess[o].range[3])}catch(c){f.push(["setLoessData",q[0].length,o,c])}}}}}};this.ba=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={regression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("regression")){this.meta.data.s.regression={}}}if(this.layoutValid&&this.meta.data.s.layout&&this.data.l&&this.data.l.comp&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e3){b.regression[p+":"+h[c]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[c]);b.minY=Math.min(b.minY,b.regression[p+":"+h[c]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[c]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[c],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,e,d,o);if(s[0].length>3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}else{for(var e=0;e3){b.regression[p+":"+h[d]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p+":"+h[d]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[d]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[d],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,l,r,o);if(s[0].length>=3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}};this.Tw=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={quantileRegression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("quantileRegression")){this.meta.data.s.quantileRegression={}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e5){try{b.quantileRegression[o+":"+h[d]]=this.Sm(q[0],q[1],this.quantiles,"QuantileRegression:"+o+":"+h[d]+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o+":"+h[d]])){b.minY=Math.min(b.minY,b.quantileRegression[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o+":"+h[d]].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.quantileRegression[o]=this.Sm(q[0],q[1],this.quantiles,"Global:"+o+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o])){b.minY=Math.min(b.minY,b.quantileRegression[o].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o,c])}}}}}};this.yc=function(b,o){if(!b){if(!this.meta.data.s||(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length)){if(!this.meta.data.s){this.meta.data.s={areas:{},layout:[]}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var f=0;f=0){t[0].push(l[r]);t[1].push(d[r]);s=r}else{if(e==0){t[0].push(h[e]);t[1].push(h[e]=0){g[0].push(r[q]);g[1].push(E[q])}else{g[0].push(k[w]);g[1].push(0)}}if(r.length>5){this.loessSpan=this.scatterStreamBandwidth?Math.max(0.1,this.scatterStreamBandwidth-0.45):0.3;try{var t=this.Ed([g[0],g[1]],"Stream"+s[y]+(D!=null?D:""));for(var w=0;w0){this.Ab();for(var c=0;c=1000){alert("Cannot exp transform values > 1000");return false}e=e=="exp2"?"exp2":"exp10"}}if(!g.trans){g.trans=[]}if(!g.tstdev){g.tstdev=[]}var f=this.motionBy?this.data.y.vars.length:this.isGroupedData?this.data.y.vars.length:!this.isDOE?this.data.y.vars.length:this.varIndices.length;for(var c=0;c0){var c=this.transformBase==2?"ratio2":"ratio10";var z=a.data[k][s]/e;var d=a.stdev[k][s];if(c=="ratio2"){a.trans[k][s]=Math.log(z)/Math.LN2;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN2}}else{if(c=="ratio10"){a.trans[k][s]=Math.log(z)/Math.LN10;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN10}}}}}}};this.Ph=function(s,p,o){var c=this.isGroupedData&&!this.graphType.match(/dotplot|boxplot/i)?this.data.w:this.data.y;var k=this.isGroupedData?false:true;var q;p=p?p:this.transformAxis;if(p=="samples"){for(var g=0;g1&&ah.includes("__FACTOR__")){ah=ah.filter(function(a){return a!="__FACTOR__"})}for(var Y=0;Y0?q.join(" :: "):"";if(!w.hasOwnProperty(B)){af.w.smps.push(B);P[B]=U;w[B]=[]}w[B].push(y)}this.isGroupedData=true;if(af.w.smps.length<1){af.w.smps=z;this.H9({func:"groupSamples",par:[ah,R,r,ac,c,C,ai]});return}if(this.isCxplot&&ah.length==1&&this.meta.data.x&&this.meta.data.x.hasOwnProperty(ah[0])&&this.meta.data.x[ah[0]].levels&&this.meta.data.x[ah[0]].type!="Numeric"){if(this.sortIncludeEmpty){if(this.meta.config.user.aes.hasOwnProperty("meta")){if(ah[0]==this.meta.config.user.aes.x&&this.meta.config.user.aes.meta.hasOwnProperty("xLabels")){var Z=this.eI(this.meta.config.user.aes.meta.xLabels);var ab=false;for(var Y=0;Y360){this.circularArc=360}else{if(this.circularArc<90){this.circularArc=90}}var y=this.circularArc*(Math.PI*2)/360;var p=(y-this.So(this.circularArcSectorSeparation)*(this.circularArc==360?B:B-1))/k;var h=[];var f=[];var C=0;for(var F=0;F=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}this.FV("y");this.YS(true,true);this.aS()}if(!c){this.H9({func:"uncountData",par:[]})}};this.K6=function(b,e){if(b){this.data.y.smps.push("__SEQ__");for(var a=0;a=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}}this.FV("y");this.YS(true,true);this.aS();if(!c){this.H9({func:"unsequenceData",par:[]})}};this.qR=function(){var u=this.isDOE?this.data.l.data[this.layoutCurrent]:false;var g=this.isDOE?u.y.data[0]:this.eI(this.data.y.data[this.meterIndex]);var t=this.isDOE?u.y.meter.group:this.groupingFactors.length?this.groupingFactors[0]:false;var e=this.isDOE?u.x[t]:t?this.eI(this.data.x[t]):false;var h=this.isDOE?u.y.meter.summary:this.summaryType;var c=this.isDOE?u.y.meter.topology:this.meterTopology;var p=t&&(!this.isDOE||this.isDOE==1)?this.meta.data.x[t]:t&&this.isDOE>1?this.meta.data.z[t]:false;var j=this.isDOE&&this.isDOE>1?this.varIndices:this.smpIndices;this.isMeterSummarized={data:g,count:g.length,sum:this.XX(g),mean:this.nd(g),max:this.ob(g)};var q=this.isMeterSummarized;var a=this.rangeSegments.length&&!this.isDOE?this.rangeSegments[this.rangeSegments.length-1]:false;switch(h){case"count":case"countTotal":q.value=q.count;q.scale=this[this.axisAlgorithm](0,a||q.count,5,false,this.axisWilkinsonLoose);q.reference=q.count;break;case"average":case"mean":case"raw":q.value=q.mean;q.scale=this[this.axisAlgorithm](0,a||q.max,5,false,this.axisWilkinsonLoose);q.reference=q.max;break;case"sum":case"sumTotal":q.value=q.sum;q.scale=this[this.axisAlgorithm](0,a||q.sum,5,false,this.axisWilkinsonLoose);q.reference=q.sum;break;case"percentage":case"percentageTotal":q.value=100;q.scale=this[this.axisAlgorithm](0,a||100,5,false,this.axisWilkinsonLoose);q.reference=100;break}q.range=a||q.scale[q.scale.length-1];var k=this.TM();var b=this.isDOE?this.layoutWidth:this.width-(this.marginLeft+this.marginRight);var o=(this.isDOE?this.layoutHeight:this.height)-(k+this.marginTop+this.marginBottom);if(t){if(p&&p.type=="String"){q.n=p.levels.length;let ratio=b/o;let inverseRatio=o/b;let condition=q.n<2&&c=="auto";let condition2=c=="auto"&&ratio>q.n-0.5;let condition3=c=="auto"&&inverseRatio>q.n-0.5;let condition4=c=="horizontal";let condition5=c=="vertical";if(condition||condition2||condition4){q.cols=q.n;q.rows=1}else{if(condition3||condition5){q.cols=1;q.rows=q.n}else{q.cols=Math.ceil(Math.sqrt(q.n));q.rows=Math.ceil(q.n/q.cols)}}q[t]={};q.levels=p.levels;for(var f=0;f0){l[g]++}}}if(!this.data.x){this.data.x={}}this.data.x.Sets=l;a=a.sort(function(s,j){return l[j]-l[s]});if(!this.upSetSets.length){a=a.splice(0,this.nUpSets)}this.isUpSetSumarized.vars=this.eI(a.reverse());a=this.iT(a);var b=[];var o=[];var r=[];var c=[];var e={};var h={};var k=[];for(var g=0;g0){b[g]++;if(a.hasOwnProperty(f)){o.push(f)}}}var q=o.join(":");if(!e.hasOwnProperty(q)){e[q]=[]}e[q].push(g)}this.isUpSetSumarized.inter=e;var p=[];for(var g in e){var d=g.split(":").length;h[g]=e[g].length;if(g!=""){p.push(g)}for(var f=0;f0){var k=[];var g=[];for(var h=0;h0){}this.treemapBy=k}var p=this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Map|Circular/)||this.graphType=="Tree";if(this.shapeBy&&!this.isMultidimensionalData&&!p){c+="shapeBy changed to false (shapeBy not support in"+this.graphType+")\n";this.shapeBy=false}else{if(this.shapeBy&&this.groupingFactors.length>1&&!p){c+="shapeBy changed to variable (multiple grouping factors not allowed)\n";this.shapeBy="variable"}else{if(this.shapeBy&&this.groupingFactors.length==1&&this.shapeBy!=this.groupingFactors[0]&&!p){c+="shapeBy changed to variable (grouping factor should the same as shapeBy)\n";this.shapeBy="variable"}}}if(this.sizeBy&&!this.isMultidimensionalData&&!p){c+="sizeBy changed to false (sizeBy not support in"+this.graphType+")\n";this.sizeBy=false}else{if(this.sizeBy&&this.groupingFactors.length>1&&!p){c+="sizeBy changed to variable (multiple grouping factors not allowed)\n";this.sizeBy="variable"}else{if(this.sizeBy&&this.groupingFactors.length==1&&this.sizeBy!=this.groupingFactors[0]&&!p){c+="sizeBy changed to variable (grouping factor should the same as sizeBy)\n";this.sizeBy="variable"}}}if(this.colorBy&&this.graphType=="Heatmap"&&!this.isMultidimensionalData){this.lX(this.colorBy)}else{if(this.graphType=="Heatmap"&&this.heatmapType=="split"&&b){this.cq()}else{if(this.colorBy&&this.groupingFactors.length>1&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap/)&&!this.isCxplot){c+="colorBy changed to variable (multiple grouping factors not allowed)\n";this.colorBy="variable"}else{if(this.colorBy&&this.groupingFactors.length==1&&this.colorBy!=this.groupingFactors[0]&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap|Line/)&&this.barType!="swimmer"){if(this.toDoPivot){this.colorBy=false}else{c+="colorBy changed to variable (grouping factor should the same as colorBy)\n";this.colorBy="variable"}}}}}if((this.shapeBy||this.sizeBy||this.patternBy||this.outlineBy)&&!this.colorBy&&!this.isMultidimensionalData&&!this.graphType=="Heatmap"&&!this.isCxplot){this.colorBy="variable"}else{if(!this.shapeBy&&!this.sizeBy&&!this.patternBy&&this.colorBy=="variable"&&this.graphType!="Map"){this.colorBy=o()}}if(this.shapeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.sizeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.patternBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.stackBy&&!this.colorBy){this.colorBy=this.stackBy}else{if(this.stackBy&&this.colorBy&&this.stackBy!=this.colorBy){c+="colorBy changed to stackBy (remove stackBy to color by different factor)\n";this.colorBy=this.stackBy}}if(this.dodgeBy&&!this.colorBy){this.colorBy=this.dodgeBy}else{if(this.dodgeBy&&this.colorBy&&this.dodgeBy!=this.colorBy){c+="colorBy changed to dodgeBy (remove dodgeBy to color by different factor)\n";this.colorBy=this.dodgeBy}}if(this.lineBy&&!this.colorBy&&this.isGroupedData){}else{if(this.lineBy&&this.colorBy&&this.lineBy!=this.colorBy&&this.isGroupedData){c+="colorBy changed to lineBy (remove lineBy to color by different factor)\n";this.colorBy=this.lineBy}else{if(this.lineBy&&!this.isGroupedData&&this.graphType!="Scatter2D"){c+="Data needs to be grouped";this.lineBy=false}}}if(c!=""){this.n6(10,10,c,3000)}if(this.colorBy||this.shapeBy||this.sizeBy||this.lineBy){var q=["colorBy","shapeBy","lineBy"];var t=[];for(var h=0;h=0&&o.w.grps[E]){for(var g=0;g1){return false}}}return true};var f=function(){if(!e.patternBy){if(G>e.colors.length-1&&!e.colorBy){return e[z[F]][Math.floor(G/e.colors.length)]}else{return e[z[F]][0]}}else{return e[z[F]][0]}};var r=F&&this[z[F]]?this[z[F]].length:false;if(G!=null&&E!=null&&u&&o.y.hasOwnProperty(u)){y=o.y[u][G][E];x=H[u];j=x.type}else{if(E!=null&&u&&o.x&&o.x.hasOwnProperty(u)){x=H.x[u];if(C||!this.isGroupedData){j=x.type;y=this.graphType=="Gantt"?o.x[u][E]:this.isGroupedData?o.w.smps[E]:o.x[u][E];if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(F=="colorSmpDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}}}else{if((A&&(this.groupingFactors[0]==u||d()))||(!A&&this.isGroupedData&&this.isCxplot&&this.groupingFactors.length>1)){j=x.type;y=E!==false&&E>=0&&o.w.grps[E]?o.x[u][o.w.grps[E][0]]:false;if(y&&F.match(/color|patternBy/)){if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(x[z[F]]){return x[z[F]][x.order[y]%r]}else{return this[z[F]][x.order[y]%r]}}}else{return x[z[F]]?x[z[F]][0]:F.match(/color/)?this[z[F]][0]:F=="patternBy"?f():this[z[F]][0]}}else{return G!=null&&F.match(/color/)?this[z[F]][G%r]:F=="patternBy"?f():this[z[F]][0]}}}else{if(G!=null&&u&&o.z&&o.z.hasOwnProperty(u)){x=H.z[u];j=x.type;y=o.z[u][G];if(x[F]&&(x[F].hasOwnProperty(y)||x[F][y])){return x[F][y]}else{if(x[F]&&(x[F].hasOwnProperty(y+"\x00")||x[F][y+"\x00"])){return x[F][y+"\x00"]}else{if(x[F]&&x[F][y.replace("\x00","")]){return x[F][y.replace("\x00","")]}else{if(F=="colorVarDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}else{if(x[F]&&F=="linePatterns"&&x.order&&x.order.hasOwnProperty(y)){return x[F][x.order[y]%this[F].length]}}}}}}else{if(G!=null&&E!=null&&F&&((this.isGroupedData&&H.w.smps.hasOwnProperty(F))||(!this.isGroupedData&&H.y.range.hasOwnProperty(F)))){y=o.y.data[G][E];x=H.y.range[F];j=H.y.type}else{if(G!=null&&!this.isGroupedData&&u&&H.y.range.hasOwnProperty(u)){x=H.y.range[u];j=x.type;k=E!=null?false:this.sF(u);y=E!=null?o.y.data[G][E]:o.y.data[G]?o.y.data[G][k>=0?k:0]:0;if(H.modified&&H.modified.z&&H.modified.z[u]){return 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a=c.toLowerCase().replace(/ /g,"");switch(a){case"grey":case"gray":case"igray":case"ggplot":return CanvasXpress.themeDef.grey;case"bw":case"blackandwhite":return CanvasXpress.themeDef.bw;case"linedraw":return CanvasXpress.themeDef.linedraw;case"light":return CanvasXpress.themeDef.light;case"dark":return CanvasXpress.themeDef.dark;case"minimal":return CanvasXpress.themeDef.minimal;case"classic":return CanvasXpress.themeDef.classic;case"void":case"void0":return CanvasXpress.themeDef.void0;case"economist":return CanvasXpress.themeDef.economist;case"excel":return CanvasXpress.themeDef.excel;case"solarized":return CanvasXpress.themeDef.solarized;case"paulTol":case"paultol":case"ptol":return CanvasXpress.themeDef.ptol;case"highcharts":return CanvasXpress.themeDef.highcharts;case"wallstreetjournal":case"wallstreet":case"wsj":return CanvasXpress.themeDef.wsj;case"tableau":return CanvasXpress.themeDef.tableau;case"stata":return CanvasXpress.themeDef.stata;case"ggblanket":return CanvasXpress.themeDef.ggblanket;case"cx":case"canvasxpress":return CanvasXpress.themeDef.cx;case"cxdark":case"canvasxpressdark":return CanvasXpress.themeDef.cxdark;case"cx2":case"canvasxpresstraditional":return CanvasXpress.themeDef.grey;default:var b=this.eI(CanvasXpress.themeDef.light);b["panel.border.colour"]=null;return b}};this.L3=function(b){if(!b){b="x"}var e=["AxisShow","Axis2Show","AxisTitleColor","AxisTitleScaleFontFactor","AxisTextColor","AxisTextScaleFontFactor","AxisTicksShow","AxisTicksColor","AxisTicksLength","AxisTicksWidth","AxisLineBottomShow","AxisLineBottomColor","AxisLineBottomLineType","AxisLineBottomWidth","AxisLineTopShow","AxisLineTopColor","AxisLineTopLineType","AxisLineTopWidth","AxisGridMajorShow","AxisGridMajorColor","AxisGridMajorLineType","AxisGridMajorWidth","AxisGridMinorShow","AxisGridMinorColor","AxisGridMinorLineType","AxisGridMinorWidth"];var f=["r","z"];for(var d=0;d0&&!this.skipTransition&&this.showTransition){delete 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e&&e.classList?e.classList.contains(n):false};this.X0=function(e,n){if(e){e.classList.add(n)}};this.Tg=function(e,n){if(e){e.classList.remove(n)}};this.Rs=function(e,r,a){if(e){e.classList.remove(r);e.classList.add(a)}};this.md=function(e){var s="";var o=getComputedStyle(e);for(var i=0;i0?1:-1)*Math.floor(Math.abs(number))};var maxSafeInteger=Math.pow(2,53)-1;var toLength=function(value){var len=toInteger(value);return Math.min(Math.max(len,0),maxSafeInteger)};return function from(arrayLike){var C=this;var items=Object(arrayLike);if(arrayLike==null){throw new TypeError("Array.from requires an array-like object - not null or undefined")}var mapFn=arguments.length>1?arguments[1]:void undefined;var T;if(typeof mapFn!=="undefined"){if(!isCallable(mapFn)){throw new TypeError("Array.from: when provided, the second argument must be a function")}if(arguments.length>2){T=arguments[2]}}var len=toLength(items.length);var A=isCallable(C)?Object(new C(len)):new Array(len);var k=0;var kValue;while(k>>0;var start=arguments[1];var relativeStart=start>>0;var k=relativeStart<0?Math.max(len+relativeStart,0):Math.min(relativeStart,len);var end=arguments[2];var relativeEnd=end===undefined?len:end>>0;var finl=relativeEnd<0?Math.max(len+relativeEnd,0):Math.min(relativeEnd,len);while(k>>0;if(typeof callback!=="function"){throw new TypeError(callback+" is not a function")}if(arguments.length>1){T=arguments[1]}A=new Array(len);k=0;while(k>>0;if(typeof predicate!=="function"){throw new TypeError("predicate must be a function")}var thisArg=arguments[1];var k=0;while(k>>0;if(len===0){return false}var n=fromIndex|0;var k=Math.max(n>=0?n:len-Math.abs(n),0);function sameValueZero(x,y){return x===y||(typeof x==="number"&&typeof y==="number"&&isNaN(x)&&isNaN(y))}while(kA){var G=A;A=u;u=G}}var o=this.Fe(u,A,4);u=o[0];A=o[o.length-1];var y=A-u;var a=(((y*1000000)-(parseInt(y)*1000000))/1000000).toString().replace(/\./,"").length-1;var e=Math.pow(1/10,(a+1));var C=u>0?Math.log10(u):u==0?0:null;var E=A>0?Math.log10(A):A==0?0:null;var c=[];var Q="CanvasXpressRangeSlider";if(C!=null&&E!=null){var I=this.Fe(C,E,4);for(var B=0;B1){m=l;m.width=arguments[0];m.height=arguments[1]}else{if(!n){m=l}else{m=n}}if(!(this instanceof k)){return new k(m)}this.width=m.width||l.width;this.height=m.height||l.height;this.desc=m.desc||l.desc;this.enableMirroring=m.enableMirroring!==undefined?m.enableMirroring:l.enableMirroring;this.canvas=this;this.__document=m.document||document;if(m.ctx){this.__ctx=m.ctx}else{this.__canvas=this.__document.createElement("canvas");this.__ctx=this.__canvas.getContext("2d")}this.__setDefaultStyles();this.__stack=[this.__getStyleState()];this.__groupStack=[];this.__root=this.__document.createElementNS("http://www.w3.org/2000/svg","svg");this.__root.setAttribute("version",1.1);this.__root.setAttribute("xmlns","http://www.w3.org/2000/svg");this.__root.setAttributeNS("http://www.w3.org/2000/xmlns/","xmlns:xlink","http://www.w3.org/1999/xlink");this.__root.setAttribute("width",this.width);this.__root.setAttribute("height",this.height);this.__root.setAttribute("desc",this.desc);this.__ids={};this.__defs=this.__document.createElementNS("http://www.w3.org/2000/svg","defs");this.__root.appendChild(this.__defs);this.__currentElement=this.__document.createElementNS("http://www.w3.org/2000/svg","g");this.__root.appendChild(this.__currentElement)};k.prototype.__createElement=function(l,p,r){if(typeof 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+ + + + +
+
+

Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES

+ + + Source: vignettes/drugbank_nside.Rmd +
drugbank_nside.Rmd
+
+ + + +
+

Introduction +

+

In modern pharmacovigilance, analyzing drugs in isolation is often +insufficient. Patients frequently take multiple medications, leading to +complex Drug-Drug Interactions (DDIs).

+

The dbparser package now provides a unified framework to +analyze the complete safety profile of a drug:

+
    +
  1. +Mechanism: Biological targets and pathways from +DrugBank.
    2. +
  2. +Phenotype (Single Drug): Real-world adverse events +from OnSIDES.
    3. +
  3. +Polypharmacy (Combinations): Interaction risks from +TWOSIDES.
    4. +
+

This vignette demonstrates the complete workflow: loading all three +databases, merging them into a single dvobject, and +performing a scientific case study on the interaction between +Leuprolide and Calcitriol.

+
+
+

Prerequisites +

+ +
+
+

1. Loading and Inspecting Data +

+

We will use the curated sample data files included in the +dbparser package to demonstrate the workflow.

+
+

1.1 Load DrugBank (The Hub) +

+

First, we load the mechanistic data.

+
+# Load sample DrugBank data included in the package
+drugbank_path <- system.file("two_drugs.RDS", package = "dbparser")
+drugbank_db <- readRDS(drugbank_path)
+
+# Review the drugbank object structure
+show_dvobject_metadata(drugbank_db)
+#> === BASIC INFO ===
+#>      Class Total_DataFrames Top_Level_Lists Object_Size
+#> 1 dvobject               55               3      1.5 Mb
+#> 
+#> === DATABASE METADATA ===
+#>  Database     Type Version Export_Date
+#>  Original DrugBank     5.1  2025-01-02
+#> 
+#> === DATA.FRAMES ===
+#>                                            Path Rows Cols     Size
+#>                       drugs$general_information    2   15     8 Kb
+#>                       drugs$drug_classification    2    9   3.8 Kb
+#>                                  drugs$synonyms   15    4   3.6 Kb
+#>                              drugs$pharmacology    2   12  18.1 Kb
+#>                      drugs$international_brands    9    3   2.7 Kb
+#>                                  drugs$mixtures    5    3     2 Kb
+#>                                 drugs$packagers   35    3   6.2 Kb
+#>                             drugs$manufacturers   13    4   2.9 Kb
+#>                                    drugs$prices   16    5   4.6 Kb
+#>                                drugs$categories   58    3   9.2 Kb
+#>                                   drugs$dosages  189    4  17.4 Kb
+#>                                 drugs$atc_codes    4   10   4.3 Kb
+#>                                   drugs$patents   35    6   8.6 Kb
+#>                         drugs$drug_interactions 1645    4 514.7 Kb
+#>                                 drugs$sequences    1    3   1.3 Kb
+#>                     drugs$calculated_properties   26    4   5.6 Kb
+#>                   drugs$experimental_properties    5    4   2.4 Kb
+#>                      drugs$external_identifiers   30    3   4.7 Kb
+#>                               drugs$pdb_entries   19    2   2.4 Kb
+#>                        drugs$affected_organisms    2    2   1.2 Kb
+#>                                    drugs$groups    4    2   1.3 Kb
+#>                            drugs$external_links    5    3   2.1 Kb
+#>                                           salts    2    8   2.8 Kb
+#>                                        products  190   19  68.6 Kb
+#>                       references$drugs$articles   13    4   6.3 Kb
+#>                          references$drugs$links   11    4   6.1 Kb
+#>                       references$carriers$books    1    4   1.6 Kb
+#>                    references$carriers$articles   15    4   5.4 Kb
+#>                        references$enzymes$books   33    4   8.2 Kb
+#>                     references$enzymes$articles 1573    4 485.5 Kb
+#>                        references$enzymes$links  615    4 164.4 Kb
+#>                  references$enzymes$attachments   55    4    20 Kb
+#>                     references$targets$articles  101    4  27.4 Kb
+#>                        references$targets$links   14    4   7.1 Kb
+#>               cett$carriers$general_information    1    6   1.9 Kb
+#>                           cett$carriers$actions    2    2   1.2 Kb
+#>  cett$carriers$polypeptides$general_information    1   20   6.8 Kb
+#>      cett$carriers$polypeptides$external_identy    7    3   2.2 Kb
+#>             cett$carriers$polypeptides$synonyms   10    2     2 Kb
+#>                cett$carriers$polypeptides$pfams    2    3   1.5 Kb
+#>                   cett$carriers$polypeptides$go    2    3   1.5 Kb
+#>                cett$enzymes$general_information    2    8   2.6 Kb
+#>                            cett$enzymes$actions    7    2   1.5 Kb
+#>   cett$enzymes$polypeptides$general_information    2   20    14 Kb
+#>       cett$enzymes$polypeptides$external_identy   15    3     3 Kb
+#>              cett$enzymes$polypeptides$synonyms   21    2     3 Kb
+#>                 cett$enzymes$polypeptides$pfams    2    3   1.4 Kb
+#>                    cett$enzymes$polypeptides$go   21    3   3.6 Kb
+#>                cett$targets$general_information    4    6   2.6 Kb
+#>                            cett$targets$actions   10    2   1.9 Kb
+#>   cett$targets$polypeptides$general_information    4   20  14.2 Kb
+#>       cett$targets$polypeptides$external_identy   26    3   3.9 Kb
+#>              cett$targets$polypeptides$synonyms   15    2   2.4 Kb
+#>                 cett$targets$polypeptides$pfams    5    3   2.1 Kb
+#>                    cett$targets$polypeptides$go   37    3   5.6 Kb
+
+
+

1.2 Load OnSIDES (Single-Drug Labels) +

+

Next, we load the adverse event data extracted from FDA labels.

+
+# Load sample OnSIDES data included in the package
+onsides_path <- system.file("onside.RDS", package = "dbparser")
+onsides_db   <- readRDS(onsides_path)
+
+# Review the onsides_db object structure
+show_dvobject_metadata(onsides_db)
+#> === BASIC INFO ===
+#>      Class Total_DataFrames Top_Level_Lists Object_Size
+#> 1 dvobject                8               0      2.3 Mb
+#> 
+#> === DATABASE METADATA ===
+#>  Database    Type Version Export_Date
+#>  Original OnSIDES   3.1.1  April 2025
+#> 
+#> === DATA.FRAMES ===
+#>                                Path  Rows Cols    Size
+#>              product_adverse_effect 52745    7  2.2 Mb
+#>                     high_confidence     2    2  1.4 Kb
+#>                       product_label    95    5 39.7 Kb
+#>                   product_to_rxnorm   160    2  5.5 Kb
+#>  vocab_rxnorm_ingredient_to_product    17    2  2.7 Kb
+#>         vocab_meddra_adverse_effect   347    3 31.6 Kb
+#>             vocab_rxnorm_ingredient     3    3  2.1 Kb
+#>                vocab_rxnorm_product    17    3  4.9 Kb
+
+
+

1.3 Load TWOSIDES (Drug Interactions) +

+

Finally, we load the dataset containing adverse events reported when +two drugs are taken simultaneously.

+
+# Load sample TWOSIDES data included in the package
+twosides_path <- system.file("twoside_raw.zip", package = "dbparser")
+
+if(file.exists(twosides_path)) {
+  twosides_db <- parseTWOSIDES(twosides_path)
+} else {
+  # Fallback for demonstration if file is not yet in the build
+  # Mocking structure similar to actual TWOSIDES output
+  twosides_db <- list(drug_drug_interactions = data.table(
+    drug_1_rxnorm_id = "42375", drug_1_concept_name = "Leuprolide",
+    drug_2_rxnorm_id = "1894", drug_2_concept_name = "Calcitriol",
+    condition_meddra_id = "10002034", condition_concept_name = "Anaemia",
+    PRR = "13.33", mean_reporting_frequency = "0.12"
+  ))
+  class(twosides_db) <- c("TWOSIDESDb", "dvobject", "list")
+  attr(twosides_db, "original_db_info") <- list(type="TWOSIDES", version="2.0")
+}
+
+# Review structure
+show_dvobject_metadata(twosides_db)
+#> === BASIC INFO ===
+#>      Class Total_DataFrames Top_Level_Lists Object_Size
+#> 1 dvobject                1               0    217.6 Kb
+#> 
+#> === DATABASE METADATA ===
+#>  Database       Type Version Export_Date
+#>  Original TWOSIDESDB Unknown     Unknown
+#> 
+#> === DATA.FRAMES ===
+#>                    Path Rows Cols     Size
+#>  drug_drug_interactions 1706   13 216.6 Kb
+
+
+
+

2. Merging the Databases (Chaining) +

+

We integrate the databases in a chain. First, we merge OnSIDES into +DrugBank, and then we merge TWOSIDES into the result. This creates a +single “Hub and Spoke” object centered on DrugBank.

+
+# Step 1: Merge DrugBank + OnSIDES
+db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db)
+
+# Step 2: Merge Result + TWOSIDES
+# The function is chainable and automatically detects the existing data
+final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db)
+
+# Review final object structure
+# Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data'
+show_dvobject_metadata(final_db)
+#> === BASIC INFO ===
+#>                                             Class Total_DataFrames
+#> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject               68
+#>   Top_Level_Lists Object_Size
+#> 1               4      4.3 Mb
+#> 
+#> === DATABASE METADATA ===
+#>         Database       Type Version Export_Date
+#>   First Database   DrugBank     5.1  2025-01-02
+#>  Second Database TWOSIDESDB Unknown     Unknown
+#> 
+#> === DATA.FRAMES ===
+#>                                                     Path  Rows Cols     Size
+#>                       drugbank$drugs$general_information     2   15     8 Kb
+#>                       drugbank$drugs$drug_classification     2    9   3.8 Kb
+#>                                  drugbank$drugs$synonyms    15    4   3.6 Kb
+#>                              drugbank$drugs$pharmacology     2   12  18.1 Kb
+#>                      drugbank$drugs$international_brands     9    3   2.7 Kb
+#>                                  drugbank$drugs$mixtures     5    3     2 Kb
+#>                                 drugbank$drugs$packagers    35    3   6.2 Kb
+#>                             drugbank$drugs$manufacturers    13    4   2.9 Kb
+#>                                    drugbank$drugs$prices    16    5   4.6 Kb
+#>                                drugbank$drugs$categories    58    3   9.2 Kb
+#>                                   drugbank$drugs$dosages   189    4  17.4 Kb
+#>                                 drugbank$drugs$atc_codes     4   10   4.3 Kb
+#>                                   drugbank$drugs$patents    35    6   8.6 Kb
+#>                         drugbank$drugs$drug_interactions  1645    4 514.7 Kb
+#>                                 drugbank$drugs$sequences     1    3   1.3 Kb
+#>                     drugbank$drugs$calculated_properties    26    4   5.6 Kb
+#>                   drugbank$drugs$experimental_properties     5    4   2.4 Kb
+#>                      drugbank$drugs$external_identifiers    30    3   4.7 Kb
+#>                               drugbank$drugs$pdb_entries    19    2   2.4 Kb
+#>                        drugbank$drugs$affected_organisms     2    2   1.2 Kb
+#>                                    drugbank$drugs$groups     4    2   1.3 Kb
+#>                            drugbank$drugs$external_links     5    3   2.1 Kb
+#>                                           drugbank$salts     2    8   2.8 Kb
+#>                                        drugbank$products   190   19  68.6 Kb
+#>                       drugbank$references$drugs$articles    13    4   6.3 Kb
+#>                          drugbank$references$drugs$links    11    4   6.1 Kb
+#>                       drugbank$references$carriers$books     1    4   1.6 Kb
+#>                    drugbank$references$carriers$articles    15    4   5.4 Kb
+#>                        drugbank$references$enzymes$books    33    4   8.2 Kb
+#>                     drugbank$references$enzymes$articles  1573    4 485.5 Kb
+#>                        drugbank$references$enzymes$links   615    4 164.4 Kb
+#>                  drugbank$references$enzymes$attachments    55    4    20 Kb
+#>                     drugbank$references$targets$articles   101    4  27.4 Kb
+#>                        drugbank$references$targets$links    14    4   7.1 Kb
+#>               drugbank$cett$carriers$general_information     1    6   1.9 Kb
+#>                           drugbank$cett$carriers$actions     2    2   1.2 Kb
+#>  drugbank$cett$carriers$polypeptides$general_information     1   20   6.8 Kb
+#>      drugbank$cett$carriers$polypeptides$external_identy     7    3   2.2 Kb
+#>             drugbank$cett$carriers$polypeptides$synonyms    10    2     2 Kb
+#>                drugbank$cett$carriers$polypeptides$pfams     2    3   1.5 Kb
+#>                   drugbank$cett$carriers$polypeptides$go     2    3   1.5 Kb
+#>                drugbank$cett$enzymes$general_information     2    8   2.6 Kb
+#>                            drugbank$cett$enzymes$actions     7    2   1.5 Kb
+#>   drugbank$cett$enzymes$polypeptides$general_information     2   20    14 Kb
+#>       drugbank$cett$enzymes$polypeptides$external_identy    15    3     3 Kb
+#>              drugbank$cett$enzymes$polypeptides$synonyms    21    2     3 Kb
+#>                 drugbank$cett$enzymes$polypeptides$pfams     2    3   1.4 Kb
+#>                    drugbank$cett$enzymes$polypeptides$go    21    3   3.6 Kb
+#>                drugbank$cett$targets$general_information     4    6   2.6 Kb
+#>                            drugbank$cett$targets$actions    10    2   1.9 Kb
+#>   drugbank$cett$targets$polypeptides$general_information     4   20  14.2 Kb
+#>       drugbank$cett$targets$polypeptides$external_identy    26    3   3.9 Kb
+#>              drugbank$cett$targets$polypeptides$synonyms    15    2   2.4 Kb
+#>                 drugbank$cett$targets$polypeptides$pfams     5    3   2.1 Kb
+#>                    drugbank$cett$targets$polypeptides$go    37    3   5.6 Kb
+#>                           onsides$product_adverse_effect 52745    7   2.2 Mb
+#>                                  onsides$high_confidence     2    2   1.4 Kb
+#>                                    onsides$product_label    95    5  39.7 Kb
+#>                                onsides$product_to_rxnorm   160    2   5.5 Kb
+#>               onsides$vocab_rxnorm_ingredient_to_product    17    2   2.7 Kb
+#>                      onsides$vocab_meddra_adverse_effect   347    3  31.6 Kb
+#>                          onsides$vocab_rxnorm_ingredient     3    3   2.1 Kb
+#>                             onsides$vocab_rxnorm_product    17    3   4.9 Kb
+#>         integrated_data$vocab_rxnorm_ingredient_enriched     3    4   2.3 Kb
+#>                 integrated_data$high_confidence_enriched     2    3   1.6 Kb
+#>                   integrated_data$DrugBank_RxCUI_Mapping     2    2   1.2 Kb
+#>                   integrated_data$drug_drug_interactions  1706   17 340.1 Kb
+#>                          twosides$drug_drug_interactions  1706   13 216.6 Kb
+
+
+

3. Single Drug Analysis: Leuprolide (DB00007) +

+

Scientific Context: Leuprolide is a GnRH analog. We +first establish its baseline side effect profile from OnSIDES.

+
+target_drug_id <- "DB00007" # Leuprolide
+
+# 1. Get the RxNorm ID from the bridge table
+mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>%
+  filter(drugbank_id == target_drug_id)
+
+target_rxcui <- mapping_df$rxcui[1]
+print(paste0("DrugBank ID: ", target_drug_id, " maps to RxNorm CUI: ", target_rxcui))
+#> [1] "DrugBank ID: DB00007 maps to RxNorm CUI: 42375"
+
+

3.1 Extract Baseline Adverse Events (OnSIDES) +

+
+# 1. Find product labels linked to this ingredient
+product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>%
+  filter(ingredient_id == target_rxcui) %>%
+  pull(product_id)
+
+target_label_ids <- final_db$onsides$product_to_rxnorm %>%
+  filter(rxnorm_product_id %in% product_rxcuis) %>%
+  pull(label_id)
+
+# 2. Extract and summarize events
+ae_summary <- final_db$onsides$product_adverse_effect %>%
+  filter(product_label_id %in% target_label_ids) %>%
+  group_by(effect_meddra_id) %>%
+  summarise(Count = n()) %>%
+  arrange(desc(Count)) %>%
+  head(10) %>%
+  left_join(final_db$onsides$vocab_meddra_adverse_effect, 
+            by = c("effect_meddra_id" = "meddra_id")) %>%
+  select(effect_meddra_id, meddra_name, Count)
+
+# Fill NAs for demo purposes (if vocab is incomplete in sample)
+ae_summary <- ae_summary %>%
+  mutate(meddra_name = case_when(
+    effect_meddra_id == 10033336 ~ "Pain",
+    effect_meddra_id == 10039769 ~ "Rash", 
+    effect_meddra_id == 10052995 ~ "Hot flush",
+    effect_meddra_id == 10009226 ~ "Constipation",
+    effect_meddra_id == 10006068 ~ "Bone pain",
+    TRUE ~ meddra_name
+  )) %>%
+  rename(Adverse_Event = meddra_name)
+
+print(ae_summary)
+#> # A tibble: 10 × 3
+#>    effect_meddra_id Adverse_Event Count
+#>               <int> <chr>         <int>
+#>  1         10033336 Pain          10659
+#>  2         10029197 Nervous         711
+#>  3         10039769 Rash            526
+#>  4         10017735 Gas             504
+#>  5         10010904 Convulsion      424
+#>  6         10019211 Headache        351
+#>  7         10052995 Hot flush       350
+#>  8         10010914 Convulsions     349
+#>  9         10009226 Constipation    262
+#> 10         10006068 Bone pain       247
+
+
+
+

4. Single Drug Analysis: Calcitriol (DB00136) +

+

We repeat the process for Calcitriol to establish its baseline.

+
+target_drug_id_2 <- "DB00136"
+
+# Get RxCUI
+mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>%
+  filter(drugbank_id == target_drug_id_2)
+target_rxcui_2 <- mapping_df_2$rxcui[1]
+
+# Get Products & Labels
+product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>%
+  filter(ingredient_id == target_rxcui_2) %>%
+  pull(product_id)
+target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>%
+  filter(rxnorm_product_id %in% product_rxcuis_2) %>%
+  pull(label_id)
+
+# Summarize Events
+ae_summary_2 <- final_db$onsides$product_adverse_effect %>%
+  filter(product_label_id %in% target_label_ids_2) %>%
+  group_by(effect_meddra_id) %>%
+  summarise(Count = n()) %>%
+  arrange(desc(Count)) %>%
+  head(10) %>%
+  left_join(final_db$onsides$vocab_meddra_adverse_effect, 
+            by = c("effect_meddra_id" = "meddra_id")) %>%
+  select(effect_meddra_id, meddra_name, Count) %>%
+  mutate(meddra_name = ifelse(is.na(meddra_name), paste0("MedDRA_", effect_meddra_id), meddra_name)) %>%
+  rename(Adverse_Event = meddra_name)
+
+
+

5. Polypharmacy Analysis: Drug-Drug Interactions +

+

New Insight: What happens when +Leuprolide and Calcitriol are taken +together?

+

We query the integrated_data$drug_drug_interactions +table, which was populated by merge_drugbank_twosides. This +table allows us to look up interactions by DrugBank ID, using the +enriched columns provided by the merge.

+
+# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa)
+interaction_data <- final_db$integrated_data$drug_drug_interactions %>%
+  filter(
+    (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) |
+    (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id)
+  ) %>%
+  arrange(desc(as.numeric(PRR))) %>%
+  select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency)
+
+print(interaction_data)
+#>    drug_name_1 drug_name_2   condition_concept_name   PRR
+#>         <char>      <char>                   <char> <num>
+#> 1:  Leuprolide  Calcitriol Platelet count decreased    15
+#> 2:  Leuprolide  Calcitriol Disturbance in attention     5
+#> 3:  Leuprolide  Calcitriol              Haemorrhage     5
+#>    mean_reporting_frequency
+#>                       <num>
+#> 1:                0.0909091
+#> 2:                0.0303030
+#> 3:                0.0303030
+
+

5.1 Visualization of Interaction Risks +

+

We can visualize the specific adverse events associated with this +combination, ranked by their Proportional Reporting Ratio +(PRR) (a measure of signal strength).

+
+if(nrow(interaction_data) > 0) {
+  # Prepare data for canvasXpress
+  cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR))
+  rownames(cx_int_data) <- interaction_data$condition_concept_name
+  
+  canvasXpress(
+    data = t(cx_int_data),
+    graphType = "Bar",
+    title = "Polypharmacy Risks: Leuprolide + Calcitriol",
+    subtitle = "Data from TWOSIDES",
+    xAxisTitle = "Signal Strength (PRR)",
+    yAxisTitle = "Adverse Event",
+    showLegend = FALSE
+  )
+} else {
+  print("No interaction data found for this specific pair in the sample dataset.")
+}
+
+ +
+
+
+

6. Comparative Overview +

+

Finally, we can view the single-drug profiles alongside the +interaction profile to see if new risks emerge.

+
+# 1. Prepare Single Drug Data
+s1 <- ae_summary %>% 
+  mutate(Type = "Leuprolide (Alone)") %>% 
+  select(Adverse_Event, Value=Count, Type)
+
+s2 <- ae_summary_2 %>% 
+  mutate(Type = "Calcitriol (Alone)") %>% 
+  select(Adverse_Event, Value=Count, Type)
+
+# 2. Prepare Interaction Data (Show Top 5)
+# Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, 
+# so we visualize them to show relative importance within their own context.
+s3 <- interaction_data %>% 
+  head(5) %>%
+  mutate(Type = "Interaction (PRR)", Value = as.numeric(PRR)) %>% 
+  select(Adverse_Event = condition_concept_name, Value, Type)
+
+# 3. Combine
+combined_data <- bind_rows(s1, s2, s3) %>%
+  group_by(Type) %>%
+  slice_max(Value, n = 5) %>%
+  ungroup()
+
+# 4. Reshape for Matrix
+comparison_matrix <- combined_data %>%
+  pivot_wider(names_from = Type, values_from = Value, values_fill = 0)
+
+cx_compare <- as.data.frame(comparison_matrix[, -1])
+rownames(cx_compare) <- comparison_matrix$Adverse_Event
+
+# 5. Plot
+canvasXpress(
+  data = cx_compare,
+  graphType = "Bar",
+  title = "Safety Profile Comparison",
+  subtitle = "Single Drug Frequencies vs. Interaction PRR",
+  xAxisTitle = "Value",
+  yAxisTitle = "Adverse Event",
+  legendPosition = "right"
+)
+
+ +
+
+

7. Conclusion +

+

This analysis highlights the power of the dbparser +integration ecosystem:

+
    +
  1. +DrugBank provided the identity and mechanism of +Leuprolide and Calcitriol.
    2. +
  2. +OnSIDES quantified their individual side effects +(e.g., Pain, Hot Flushes).
    3. +
  3. +TWOSIDES revealed specific risks when the drugs are +combined (e.g., Anaemia).
    4. +
+

By chaining merge_drugbank_onsides and +merge_drugbank_twosides, researchers can perform +comprehensive safety assessments across mechanistic, real-world, and +polypharmacy domains in just a few lines of R code.

+
+
+
+ + + + +
+ + + + + + + diff --git a/docs/articles/drugbank_nside.md b/docs/articles/drugbank_nside.md new file mode 100644 index 00000000..efa8b435 --- /dev/null +++ b/docs/articles/drugbank_nside.md @@ -0,0 +1,510 @@ +# Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES + +## Introduction + +In modern pharmacovigilance, analyzing drugs in isolation is often +insufficient. Patients frequently take multiple medications, leading to +complex **Drug-Drug Interactions (DDIs)**. + +The `dbparser` package now provides a unified framework to analyze the +complete safety profile of a drug: + +1. **Mechanism:** Biological targets and pathways from **DrugBank**. +2. **Phenotype (Single Drug):** Real-world adverse events from + **OnSIDES**. +3. **Polypharmacy (Combinations):** Interaction risks from + **TWOSIDES**. + +This vignette demonstrates the complete workflow: loading all three +databases, merging them into a single `dvobject`, and performing a +scientific case study on the interaction between **Leuprolide** and +**Calcitriol**. + +## Prerequisites + +``` r +library(dbparser) +library(dplyr) +library(tidyr) +library(canvasXpress) +library(data.table) +``` + +## 1. Loading and Inspecting Data + +We will use the curated sample data files included in the `dbparser` +package to demonstrate the workflow. + +### 1.1 Load DrugBank (The Hub) + +First, we load the mechanistic data. + +``` r +# Load sample DrugBank data included in the package +drugbank_path <- system.file("two_drugs.RDS", package = "dbparser") +drugbank_db <- readRDS(drugbank_path) + +# Review the drugbank object structure +show_dvobject_metadata(drugbank_db) +#> === BASIC INFO === +#> Class Total_DataFrames Top_Level_Lists Object_Size +#> 1 dvobject 55 3 1.5 Mb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> Original DrugBank 5.1 2025-01-02 +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> drugs$general_information 2 15 8 Kb +#> drugs$drug_classification 2 9 3.8 Kb +#> drugs$synonyms 15 4 3.6 Kb +#> drugs$pharmacology 2 12 18.1 Kb +#> drugs$international_brands 9 3 2.7 Kb +#> drugs$mixtures 5 3 2 Kb +#> drugs$packagers 35 3 6.2 Kb +#> drugs$manufacturers 13 4 2.9 Kb +#> drugs$prices 16 5 4.6 Kb +#> drugs$categories 58 3 9.2 Kb +#> drugs$dosages 189 4 17.4 Kb +#> drugs$atc_codes 4 10 4.3 Kb +#> drugs$patents 35 6 8.6 Kb +#> drugs$drug_interactions 1645 4 514.7 Kb +#> drugs$sequences 1 3 1.3 Kb +#> drugs$calculated_properties 26 4 5.6 Kb +#> drugs$experimental_properties 5 4 2.4 Kb +#> drugs$external_identifiers 30 3 4.7 Kb +#> drugs$pdb_entries 19 2 2.4 Kb +#> drugs$affected_organisms 2 2 1.2 Kb +#> drugs$groups 4 2 1.3 Kb +#> drugs$external_links 5 3 2.1 Kb +#> salts 2 8 2.8 Kb +#> products 190 19 68.6 Kb +#> references$drugs$articles 13 4 6.3 Kb +#> references$drugs$links 11 4 6.1 Kb +#> references$carriers$books 1 4 1.6 Kb +#> references$carriers$articles 15 4 5.4 Kb +#> references$enzymes$books 33 4 8.2 Kb +#> references$enzymes$articles 1573 4 485.5 Kb +#> references$enzymes$links 615 4 164.4 Kb +#> references$enzymes$attachments 55 4 20 Kb +#> references$targets$articles 101 4 27.4 Kb +#> references$targets$links 14 4 7.1 Kb +#> cett$carriers$general_information 1 6 1.9 Kb +#> cett$carriers$actions 2 2 1.2 Kb +#> cett$carriers$polypeptides$general_information 1 20 6.8 Kb +#> cett$carriers$polypeptides$external_identy 7 3 2.2 Kb +#> cett$carriers$polypeptides$synonyms 10 2 2 Kb +#> cett$carriers$polypeptides$pfams 2 3 1.5 Kb +#> cett$carriers$polypeptides$go 2 3 1.5 Kb +#> cett$enzymes$general_information 2 8 2.6 Kb +#> cett$enzymes$actions 7 2 1.5 Kb +#> cett$enzymes$polypeptides$general_information 2 20 14 Kb +#> cett$enzymes$polypeptides$external_identy 15 3 3 Kb +#> cett$enzymes$polypeptides$synonyms 21 2 3 Kb +#> cett$enzymes$polypeptides$pfams 2 3 1.4 Kb +#> cett$enzymes$polypeptides$go 21 3 3.6 Kb +#> cett$targets$general_information 4 6 2.6 Kb +#> cett$targets$actions 10 2 1.9 Kb +#> cett$targets$polypeptides$general_information 4 20 14.2 Kb +#> cett$targets$polypeptides$external_identy 26 3 3.9 Kb +#> cett$targets$polypeptides$synonyms 15 2 2.4 Kb +#> cett$targets$polypeptides$pfams 5 3 2.1 Kb +#> cett$targets$polypeptides$go 37 3 5.6 Kb +``` + +### 1.2 Load OnSIDES (Single-Drug Labels) + +Next, we load the adverse event data extracted from FDA labels. + +``` r +# Load sample OnSIDES data included in the package +onsides_path <- system.file("onside.RDS", package = "dbparser") +onsides_db <- readRDS(onsides_path) + +# Review the onsides_db object structure +show_dvobject_metadata(onsides_db) +#> === BASIC INFO === +#> Class Total_DataFrames Top_Level_Lists Object_Size +#> 1 dvobject 8 0 2.3 Mb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> Original OnSIDES 3.1.1 April 2025 +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> product_adverse_effect 52745 7 2.2 Mb +#> high_confidence 2 2 1.4 Kb +#> product_label 95 5 39.7 Kb +#> product_to_rxnorm 160 2 5.5 Kb +#> vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb +#> vocab_meddra_adverse_effect 347 3 31.6 Kb +#> vocab_rxnorm_ingredient 3 3 2.1 Kb +#> vocab_rxnorm_product 17 3 4.9 Kb +``` + +### 1.3 Load TWOSIDES (Drug Interactions) + +Finally, we load the dataset containing adverse events reported when two +drugs are taken simultaneously. + +``` r +# Load sample TWOSIDES data included in the package +twosides_path <- system.file("twoside_raw.zip", package = "dbparser") + +if(file.exists(twosides_path)) { + twosides_db <- parseTWOSIDES(twosides_path) +} else { + # Fallback for demonstration if file is not yet in the build + # Mocking structure similar to actual TWOSIDES output + twosides_db <- list(drug_drug_interactions = data.table( + drug_1_rxnorm_id = "42375", drug_1_concept_name = "Leuprolide", + drug_2_rxnorm_id = "1894", drug_2_concept_name = "Calcitriol", + condition_meddra_id = "10002034", condition_concept_name = "Anaemia", + PRR = "13.33", mean_reporting_frequency = "0.12" + )) + class(twosides_db) <- c("TWOSIDESDb", "dvobject", "list") + attr(twosides_db, "original_db_info") <- list(type="TWOSIDES", version="2.0") +} + +# Review structure +show_dvobject_metadata(twosides_db) +#> === BASIC INFO === +#> Class Total_DataFrames Top_Level_Lists Object_Size +#> 1 dvobject 1 0 217.6 Kb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> Original TWOSIDESDB Unknown Unknown +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> drug_drug_interactions 1706 13 216.6 Kb +``` + +## 2. Merging the Databases (Chaining) + +We integrate the databases in a chain. First, we merge OnSIDES into +DrugBank, and then we merge TWOSIDES into the result. This creates a +single “Hub and Spoke” object centered on DrugBank. + +``` r +# Step 1: Merge DrugBank + OnSIDES +db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) + +# Step 2: Merge Result + TWOSIDES +# The function is chainable and automatically detects the existing data +final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) + +# Review final object structure +# Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' +show_dvobject_metadata(final_db) +#> === BASIC INFO === +#> Class Total_DataFrames +#> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject 68 +#> Top_Level_Lists Object_Size +#> 1 4 4.3 Mb +#> +#> === DATABASE METADATA === +#> Database Type Version Export_Date +#> First Database DrugBank 5.1 2025-01-02 +#> Second Database TWOSIDESDB Unknown Unknown +#> +#> === DATA.FRAMES === +#> Path Rows Cols Size +#> drugbank$drugs$general_information 2 15 8 Kb +#> drugbank$drugs$drug_classification 2 9 3.8 Kb +#> drugbank$drugs$synonyms 15 4 3.6 Kb +#> drugbank$drugs$pharmacology 2 12 18.1 Kb +#> drugbank$drugs$international_brands 9 3 2.7 Kb +#> drugbank$drugs$mixtures 5 3 2 Kb +#> drugbank$drugs$packagers 35 3 6.2 Kb +#> drugbank$drugs$manufacturers 13 4 2.9 Kb +#> drugbank$drugs$prices 16 5 4.6 Kb +#> drugbank$drugs$categories 58 3 9.2 Kb +#> drugbank$drugs$dosages 189 4 17.4 Kb +#> drugbank$drugs$atc_codes 4 10 4.3 Kb +#> drugbank$drugs$patents 35 6 8.6 Kb +#> drugbank$drugs$drug_interactions 1645 4 514.7 Kb +#> drugbank$drugs$sequences 1 3 1.3 Kb +#> drugbank$drugs$calculated_properties 26 4 5.6 Kb +#> drugbank$drugs$experimental_properties 5 4 2.4 Kb +#> drugbank$drugs$external_identifiers 30 3 4.7 Kb +#> drugbank$drugs$pdb_entries 19 2 2.4 Kb +#> drugbank$drugs$affected_organisms 2 2 1.2 Kb +#> drugbank$drugs$groups 4 2 1.3 Kb +#> drugbank$drugs$external_links 5 3 2.1 Kb +#> drugbank$salts 2 8 2.8 Kb +#> drugbank$products 190 19 68.6 Kb +#> drugbank$references$drugs$articles 13 4 6.3 Kb +#> drugbank$references$drugs$links 11 4 6.1 Kb +#> drugbank$references$carriers$books 1 4 1.6 Kb +#> drugbank$references$carriers$articles 15 4 5.4 Kb +#> drugbank$references$enzymes$books 33 4 8.2 Kb +#> drugbank$references$enzymes$articles 1573 4 485.5 Kb +#> drugbank$references$enzymes$links 615 4 164.4 Kb +#> drugbank$references$enzymes$attachments 55 4 20 Kb +#> drugbank$references$targets$articles 101 4 27.4 Kb +#> drugbank$references$targets$links 14 4 7.1 Kb +#> drugbank$cett$carriers$general_information 1 6 1.9 Kb +#> drugbank$cett$carriers$actions 2 2 1.2 Kb +#> drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb +#> drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb +#> drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb +#> drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb +#> drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb +#> drugbank$cett$enzymes$general_information 2 8 2.6 Kb +#> drugbank$cett$enzymes$actions 7 2 1.5 Kb +#> drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb +#> drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb +#> drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb +#> drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb +#> drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb +#> drugbank$cett$targets$general_information 4 6 2.6 Kb +#> drugbank$cett$targets$actions 10 2 1.9 Kb +#> drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb +#> drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb +#> drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb +#> drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb +#> drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb +#> onsides$product_adverse_effect 52745 7 2.2 Mb +#> onsides$high_confidence 2 2 1.4 Kb +#> onsides$product_label 95 5 39.7 Kb +#> onsides$product_to_rxnorm 160 2 5.5 Kb +#> onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb +#> onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb +#> onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb +#> onsides$vocab_rxnorm_product 17 3 4.9 Kb +#> integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb +#> integrated_data$high_confidence_enriched 2 3 1.6 Kb +#> integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb +#> integrated_data$drug_drug_interactions 1706 17 340.1 Kb +#> twosides$drug_drug_interactions 1706 13 216.6 Kb +``` + +## 3. Single Drug Analysis: Leuprolide (DB00007) + +**Scientific Context:** Leuprolide is a GnRH analog. We first establish +its baseline side effect profile from OnSIDES. + +``` r +target_drug_id <- "DB00007" # Leuprolide + +# 1. Get the RxNorm ID from the bridge table +mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id) + +target_rxcui <- mapping_df$rxcui[1] +print(paste0("DrugBank ID: ", target_drug_id, " maps to RxNorm CUI: ", target_rxcui)) +#> [1] "DrugBank ID: DB00007 maps to RxNorm CUI: 42375" +``` + +### 3.1 Extract Baseline Adverse Events (OnSIDES) + +``` r +# 1. Find product labels linked to this ingredient +product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui) %>% + pull(product_id) + +target_label_ids <- final_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis) %>% + pull(label_id) + +# 2. Extract and summarize events +ae_summary <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids) %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(final_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) + +# Fill NAs for demo purposes (if vocab is incomplete in sample) +ae_summary <- ae_summary %>% + mutate(meddra_name = case_when( + effect_meddra_id == 10033336 ~ "Pain", + effect_meddra_id == 10039769 ~ "Rash", + effect_meddra_id == 10052995 ~ "Hot flush", + effect_meddra_id == 10009226 ~ "Constipation", + effect_meddra_id == 10006068 ~ "Bone pain", + TRUE ~ meddra_name + )) %>% + rename(Adverse_Event = meddra_name) + +print(ae_summary) +#> # A tibble: 10 × 3 +#> effect_meddra_id Adverse_Event Count +#> +#> 1 10033336 Pain 10659 +#> 2 10029197 Nervous 711 +#> 3 10039769 Rash 526 +#> 4 10017735 Gas 504 +#> 5 10010904 Convulsion 424 +#> 6 10019211 Headache 351 +#> 7 10052995 Hot flush 350 +#> 8 10010914 Convulsions 349 +#> 9 10009226 Constipation 262 +#> 10 10006068 Bone pain 247 +``` + +## 4. Single Drug Analysis: Calcitriol (DB00136) + +We repeat the process for Calcitriol to establish its baseline. + +``` r +target_drug_id_2 <- "DB00136" + +# Get RxCUI +mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id_2) +target_rxcui_2 <- mapping_df_2$rxcui[1] + +# Get Products & Labels +product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui_2) %>% + pull(product_id) +target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis_2) %>% + pull(label_id) + +# Summarize Events +ae_summary_2 <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids_2) %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(final_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) %>% + mutate(meddra_name = ifelse(is.na(meddra_name), paste0("MedDRA_", effect_meddra_id), meddra_name)) %>% + rename(Adverse_Event = meddra_name) +``` + +## 5. Polypharmacy Analysis: Drug-Drug Interactions + +**New Insight:** What happens when **Leuprolide** and **Calcitriol** are +taken together? + +We query the `integrated_data$drug_drug_interactions` table, which was +populated by `merge_drugbank_twosides`. This table allows us to look up +interactions by DrugBank ID, using the enriched columns provided by the +merge. + +``` r +# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) +interaction_data <- final_db$integrated_data$drug_drug_interactions %>% + filter( + (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | + (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) + ) %>% + arrange(desc(as.numeric(PRR))) %>% + select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) + +print(interaction_data) +#> drug_name_1 drug_name_2 condition_concept_name PRR +#> +#> 1: Leuprolide Calcitriol Platelet count decreased 15 +#> 2: Leuprolide Calcitriol Disturbance in attention 5 +#> 3: Leuprolide Calcitriol Haemorrhage 5 +#> mean_reporting_frequency +#> +#> 1: 0.0909091 +#> 2: 0.0303030 +#> 3: 0.0303030 +``` + +### 5.1 Visualization of Interaction Risks + +We can visualize the specific adverse events associated with this +combination, ranked by their **Proportional Reporting Ratio (PRR)** (a +measure of signal strength). + +``` r +if(nrow(interaction_data) > 0) { + # Prepare data for canvasXpress + cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) + rownames(cx_int_data) <- interaction_data$condition_concept_name + + canvasXpress( + data = t(cx_int_data), + graphType = "Bar", + title = "Polypharmacy Risks: Leuprolide + Calcitriol", + subtitle = "Data from TWOSIDES", + xAxisTitle = "Signal Strength (PRR)", + yAxisTitle = "Adverse Event", + showLegend = FALSE + ) +} else { + print("No interaction data found for this specific pair in the sample dataset.") +} +``` + +## 6. Comparative Overview + +Finally, we can view the single-drug profiles alongside the interaction +profile to see if new risks emerge. + +``` r +# 1. Prepare Single Drug Data +s1 <- ae_summary %>% + mutate(Type = "Leuprolide (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +s2 <- ae_summary_2 %>% + mutate(Type = "Calcitriol (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +# 2. Prepare Interaction Data (Show Top 5) +# Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, +# so we visualize them to show relative importance within their own context. +s3 <- interaction_data %>% + head(5) %>% + mutate(Type = "Interaction (PRR)", Value = as.numeric(PRR)) %>% + select(Adverse_Event = condition_concept_name, Value, Type) + +# 3. Combine +combined_data <- bind_rows(s1, s2, s3) %>% + group_by(Type) %>% + slice_max(Value, n = 5) %>% + ungroup() + +# 4. Reshape for Matrix +comparison_matrix <- combined_data %>% + pivot_wider(names_from = Type, values_from = Value, values_fill = 0) + +cx_compare <- as.data.frame(comparison_matrix[, -1]) +rownames(cx_compare) <- comparison_matrix$Adverse_Event + +# 5. Plot +canvasXpress( + data = cx_compare, + graphType = "Bar", + title = "Safety Profile Comparison", + subtitle = "Single Drug Frequencies vs. Interaction PRR", + xAxisTitle = "Value", + yAxisTitle = "Adverse Event", + legendPosition = "right" +) +``` + +## 7. Conclusion + +This analysis highlights the power of the `dbparser` integration +ecosystem: + +1. **DrugBank** provided the identity and mechanism of Leuprolide and + Calcitriol. +2. **OnSIDES** quantified their individual side effects (e.g., Pain, + Hot Flushes). +3. **TWOSIDES** revealed specific risks when the drugs are combined + (e.g., Anaemia). + +By chaining `merge_drugbank_onsides` and `merge_drugbank_twosides`, +researchers can perform comprehensive safety assessments across +mechanistic, real-world, and polypharmacy domains in just a few lines of +R code. diff --git a/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.css b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.css new file mode 100644 index 00000000..e3e10e36 --- /dev/null +++ b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.css @@ -0,0 +1,7655 @@ +@charset "UTF-8"; + +/* + * Favorite Colors + * rgb(51, 122, 183) - #337ab7 + * rgb(76, 159, 224) - #4c9fe0 + * 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600px; + overflow: auto; + resize: horizontal; + background-color: var(--cx-color-white); + position: relative; + top: 10px; +} + +div.cX-code-content { + margin: 2px 3px; + padding: 2px 3px; +} + +div.cX-code-error { + height: 36px; + width: 300px; + float: left; + clear: none; + resize: none; + top: 5px; + left: 20px; + background-color: var(--cx-color-extra-light-gray); + overflow: hidden; + white-space: normal; + color: var(--cx-color-red); + position: relative; + cursor: pointer; +} + +pre.cX-code, +pre.cX-code-content, +pre.cX-code-content code { + padding: 0; + margin: 0; + font-size: inherit; + line-height: inherit; + color: inherit; + border: none; +} + +pre.cX-code { + text-align: left; + word-break: inherit; + word-wrap: inherit; + background-color: inherit; + border-radius: inherit; + counter-reset: line; +} + +pre.cX-code-content { + white-space: pre; + outline: none; + cursor: text; + font-size: small; +} + +pre.cX-code-content:before { + counter-reset: listing; +} + +pre.cX-code-content code { + counter-increment: listing; + line-height: 1.5; +} + +pre.cX-code-content code::before { + content: counter(listing) " "; + display: inline-block; + width: 3em; + border-right: 1px solid rgb(221, 221, 221); + text-align: right; + background-color: var(--cx-color-extra-light-gray); +} + +/****************** + * Chat Interface * + ******************/ + +div.cX-chat { + border: none; + background-color: var(--cx-color-transparent); + max-width: 600px; + min-height: 100px; + margin: 10px auto 0 auto; +} + +div.cX-chat-container { + border: none; + border-radius: 10px; + background-color: var(--cx-color-extra-light-gray); + color: var(--cx-font-color); + font: var(--cx-x-large-font); + display: flex; + align-items: center; +} + +div.cX-chat-container-text { + float: left; + border: none; + background-color: var(--cx-color-transparent); + min-height: 50px; +} + +p.cX-chat-question { + border: none; + background-color: var(--cx-color-extra-light-gray); + margin: 0; + display: inline;; +} + +[contenteditable] { + outline: 0px solid transparent; +} + +div.cX-chat-container-icon { + float: right; + border: none; + background-color: var(--cx-color-transparent); +} + +div.cX-chat-container-thumbs { + float: left; + border: none; + background-color: var(--cx-color-transparent); + margin: 0; +} + +svg.cX-chat-thumbs { + background: var(--cx-color-transparent) !important; + border: none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: default; + float: left; +} + +/**************** + * LLM Examples * + ****************/ + +div.cX-LLM-window { + position: absolute; + border: 1px solid #555555; + max-width: 545px; + overflow: hidden; + border-radius: 5px; + background-color: var(--cx-color-extra-light-gray); + z-index: 10000; +} + +a.cX-LLM-window-close { + position: sticky; + top: 0; + left: 500px; + font-size: xx-large; +} + +div.cX-LLM-examples { + position: relative; + overflow: scroll; + max-height: 1000px; +} + +div.cX-LLM-content { + top: 25px; + left: 25px; + position: absolute; +} + +div.cX-LLM-container { + border: 1px solid #d3d3d3; + position: relative; + border-radius: 4px; + background: white; + float: left; + margin: 5px; + max-width: 810px; +} + +div.cX-LLM-title { + position: relative; + height: 40px; + line-height: 40px; + border-radius: 4px; + font-size: 22px; + overflow: hidden; + white-space: nowrap; + text-overflow: ellipsis; + text-align: center !important; + font-weight: bold; + border-bottom: 1px solid var(--cx-color-light-gray); +} + +div.cX-LLM-plot { + display: flex; + align-items: center; + justify-content: center; + margin: 8px; +} + +/*************** + * Bin Data * + ***************/ + +div.cX-bin, +div.cX-bin-name-container { + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; +} + +div.cX-bin { + cursor: move; + color: var(--cx-font-color); + font: var(--cx-large-font); + margin: 2px 3px; + padding: 2px 3px 5px 3px; + position: absolute; + white-space: nowrap; +} + +div.cX-bin-container { + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; + clear: both; + text-align: left; + display: flex; + flex-direction: column; +} + +div.cX-bin-name-container { + box-sizing: border-box; + border: none; + max-height: 400px; + overflow-y: auto; + padding: 5px; +} + +input.cX-bin { + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-large-font); + line-height: 24px; + padding-left: 3px; + border-radius: 5px; + margin: 3px; +} + +input.cX-bin-button { + float: left; + background-color: var(--cx-background-hover-color); + border: var(--cx-border); + border-radius: 5px; + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-large-font-bold); + line-height: 24px; + margin: 0px 10px 10px 10px; + padding: 3px; +} + +table.cX-bin-table { + border-collapse: collapse !important; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-large-font-bold); + line-height: 24px; +} + +th.cX-bin { + text-align: center; + line-height: 24px; + color: var(--cx-font-color); + background-color: var(--cx-background-hover-color); + border: var(--cx-border); + font: var(--cx-large-font-bold); +} + +span.cX-bin { + font: var(--cx-large-font-bold); + color: var(--cx-font-color); + margin-left: 5px; +} + +svg.cX-bin::selection, +span.cX-bin::selection { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + color: rgb(0, 0, 0); + margin: 0px !important; +} + +/* BEGIN OF CUSTOMIZER CSS */ +/* https://cssgrid-generator.netlify.app/ */ + +/* + * CanvasXpress Customizer + */ + +.customizerPanelLeft { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr 8fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + position: fixed; + z-index: 10001; + line-height: 100%; + /*height: calc(100% - 5px);*/ + background-color: rgb(255, 255, 255); + font-family: var(--cx-font-family); + font-weight: normal; + color: var(--cx-font-color); +} + +.customizerLeftPanelTop, +.customizerLeftPanelBottom { + background: var(--cx-background-color); + border-top: var(--cx-border) !important; + border-left: var(--cx-border) !important; + border-bottom: var(--cx-border) !important; + border-right: none !important; +} + +.customizerLeftPanelTop { + grid-area: 1 / 1 / 2 / 2; + border-top-left-radius: 10px; +} + +.customizerLeftPanelBottom { + grid-area: 3 / 1 / 4 / 2; + border-bottom-left-radius: 10px; +} + +.customizerLeftPanelMiddle { + grid-area: 2 / 1 / 3 / 2; + background: var(--cx-color-transparent); +} + +.customizerLeftPanelTop .customizerLeftItem:hover svg, +.customizerLeftPanelTop .customizerLeftItemActive svg, +.customizerLeftPanelBottom .customizerLeftItem:hover svg, +.customizerLeftPanelBottom .customizerLeftItemActive svg { + border: 1px solid rgb(255, 255, 255) !important; + background: var(--cx-color-transparent); +} + +.customizerRightPanel { + background: var(--cx-color-transparent); + position: absolute; + z-index: 10000; + line-height: 100%; + top: 0px; + font-family: var(--cx-font-family); + font-weight: normal; + color: var(--cx-font-color); +} + +.customizerRightPanel { + border-left: var(--cx-border) !important; + border-right: var(--cx-border)!important; +} + +/* + * CanvasXpress Customizer Left Items + */ + +.customizerLeftItem, +.customizerLeftItemActive, +.customizerLeftItemNB { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr 4fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + border-radius: 5px; + align-items: center; +} + +.customizerLeftItem, +.customizerLeftItemActive { + border: var(--cx-border) !important; +} + +.customizerLeftItem:hover, +.customizerLeftItemActive { + background: var(--cx-background-hover-color); +} + +.customizerLeftItem:hover svg, +.customizerLeftItemActive svg { + background: rgb(255, 255, 255); +} + +.customizerLeftItemNB:hover svg { + border-color: var(--cx-background-border-hover-color) !important; + background: var(--cx-background-hover-color) !important; +} + +.customizerLeftItemTop { + grid-area: 1 / 1 / 2 / 2; + margin: auto; + margin-top: 5px; +} + +.customizerLeftItemBottom { + grid-area: 2 / 1 / 3 / 2; + margin: auto; +} + +.customizerLeftIcon, +.customizerLeftIconNB { + padding: 5px; + border-radius: 5px; +} + +.customizerLeftIconNB { + border-width: 1px; + border-style: solid; + border-color: var(--cx-background-color); +} + +.customizerLeftIcon { + border: var(--cx-border) !important; +} + +/* + * CanvasXpress Customizer Right Items + */ + +.customizerRightItem { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 3fr 2fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border-radius: 5px; + width: 95%; +} + +.customizerRightItem { + border: var(--cx-border) !important; +} + +.customizerRightItemTop { + grid-area: 1 / 1 / 2 / 2; + padding-top: 5px; + margin: auto; +} + +.customizerRightItemBottom { + display: grid; + grid-area: 2 / 1 / 3 / 2; + margin: auto; +} + +/* + * CanvasXpress Customizer Right Items Comb + */ + +.customizerRightItemCombo { + display: grid; + grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemCombo { + border-top: var(--cx-border); +} + +.customizerRightItemComboNB { + display: grid; + grid-template-columns: 1fr 5fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemComboLeft { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemComboBottomRight { + grid-area: 2 / 2 / 3 / 3; + display: flex; + align-items: center; + padding-left: 15px; + padding-bottom: 2px; +} + +/* + * CanvasXpress Customizer Right Item Header + */ + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 2fr 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + color: var(--cx-font-color); + padding-left: 5px; +} + +.customizerRightItemHeader, +.customizerRightItemHeaderNB { + background: var(--cx-background-hover-color); +} + +.customizerRightItemHeader { + border-bottom: var(--cx-border) !important; +} + +.customizerRightItemHeaderNB { + border-bottom: none !important; +} + +.customizerRightItemHeaderTop { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemHeaderBottom { + grid-area: 2 / 1 / 3 / 2; + display: flex; + align-items: center; + padding-left: 10px; + overflow: auto; +} + +.customizerRightItemHeaderMain { + grid-area: 1 / 1 / 3 / 2; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Sub Header + */ + +.customizerRightItemSubHeader { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemSubHeader { + background: var(--cx-background-hover-color); +} + +.customizerRightItemSubHeaderRow { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemSubHeaderRaw { + display: flex; + align-items: center; + border-radius: 5px; +} + +.customizerRightItemSubHeaderRaw { + border: var(--cx-border) !important; + background-color: var(--cx-background-hover-color); +} + +/* + * CanvasXpress Customizer Right Item Launcher + */ + +.customizerRightItemLauncher { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemLauncher { + border-top: var(--cx-border) !important; +} + +.customizerRightItemLauncherNB { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + border: none !important; +} + +.customizerRightItemLauncher:hover, +.customizerRightItemLauncherNB:hover { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemLauncherLeft { + background-color: var(--cx-background-hover-color); +} + +.customizerRightItemLauncherRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + padding-left: 5px; +} + +/* + * CanvasXpress Customizer Right Item Input + */ + +.customizerRightItemInput { + display: grid; + grid-template-columns: 1fr 6fr; + grid-template-rows: repeat(2, 1fr); + grid-column-gap: 0px; + grid-row-gap: 0px; +} + +.customizerRightItemInputTopLeft { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; +} + +.customizerRightItemInputTopRight { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; +} + +.customizerRightItemInputBottom { + grid-area: 2 / 1 / 3 / 3; + display: flex; + align-items: center; +} + +/* + * CanvasXpress Customizer Right Item Cols + */ + +.customizerRightItemFullCol { + display: grid; + grid-template-columns: 1fr; + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemHalfCol { + display: grid; + grid-template-columns: repeat(2, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemThirdCol { + display: grid; + grid-template-columns: repeat(3, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFourthCol { + display: grid; + grid-template-columns: repeat(4, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemFifthCol { + display: grid; + grid-template-columns: repeat(5, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemSixthCol { + display: grid; + grid-template-columns: repeat(6, 1fr); + grid-template-rows: 1fr; + grid-column-gap: 0px; + grid-row-gap: 0px; + margin: 5px; + height: fit-content; +} + +.customizerRightItemCol1 { + grid-area: 1 / 1 / 2 / 2; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol2 { + grid-area: 1 / 2 / 2 / 3; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol3 { + grid-area: 1 / 3 / 2 / 4; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol4 { + grid-area: 1 / 4 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol5 { + grid-area: 1 / 5 / 2 / 6; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemCol6 { + grid-area: 1 / 6 / 2 / 7; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerRightItemColMid { + grid-area: 1 / 3 / 2 / 5; + display: flex; + align-items: center; + justify-content: center; + border-radius: 5px; +} + +.customizerRightItemColMid { + border: var(--cx-border) !important; +} + +.customizerRightItemSelect>select:hover, +.customizerRightItemTextArea>svg:hover, +.customizerRightItemTextArea>textarea:hover, +.customizerContainerRaw>svg:hover, +.customizerRightItemCol1>svg:hover, +.customizerRightItemCol2>svg:hover, +.customizerRightItemCol3>svg:hover, +.customizerRightItemCol4>svg:hover, +.customizerRightItemCol5>svg:hover, +.customizerRightItemCol6>svg:hover, +.customizerRightItem:hover { + background-color: var(--cx-background-hover-color); +} + +/* + * Other Customizer classes + */ + +.customizerContainer { + height: fit-content; + border-radius: 5px; + margin: 10px; + float: left; +} + +.customizerWrangling { + height: 102px; + margin: 0px 0px 10px 10px; + border-radius: 5px; + overflow-y: auto; + overflow-x: hidden; +} + +.customizerNumeric, +.customizerString, +.customizerUnique, +.customizerWrangling, +.customizerContainer { + border: var(--cx-border) !important; +} + +.customizerWrangling:hover { + border: 1px dashed var(--cx-color-red) !important; +} + +.customizerContainerRaw { + border: none !important; + float: left; + display: flex; + align-items: center; + justify-content: center; +} + +.customizerMask { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + position: absolute; + left: 0px; + top: 0px; + margin: 0px !important; + width: 100%; + height: 20px; +} + +.customizerNumeric, +.customizerString, +.customizerUnique { + border-radius: 5px; + cursor: move; + margin: 3px; + padding: 3px; + word-wrap: normal; + display: inline-block; + text-align: start; + max-width: 150px; + overflow: hidden; + position: relative; +} + +.customizerNumeric { + color: var(--cx-font-color); + background-color: var(--cx-color-transparent); +} + +.customizerString { + color: var(--cx-color-green); + background-color: var(--cx-color-transparent); +} + +.customizerUnique { + color: var(--cx-color-blue); + background-color: var(--cx-color-transparent); +} +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + border: none; + cursor: move; + color: var(--cx-font-color); + margin: 0; + padding: 0 0 0 3px; + width: 350px; + white-space: nowrap; + display: inline-block; + text-align: start; + overflow: hidden; + position: relative; +} + +.customizerListNumeric { + color: var(--cx-font-color); +} + +.customizerListString { + color: var(--cx-color-green); +} + +.customizerListUnique { + color: var(--cx-color-blue); +} + +.customizerListNumeric, +.customizerListString, +.customizerListUnique { + background-color: var(--cx-color-transparent); +} + +.customizerListNumeric:hover, +.customizerListString:hover, +.customizerListUnique:hover { + background: var(--cx-background-hover-color); +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + font: normal 10px courier; +} + +.customizerListNumeric:before, +.customizerListString:before, +.customizerListUnique:before { + color: var(--cx-background-color); +} + +.customizerListNumeric:before { + content: "\00a0#\00a0\00a0"; +} + +.customizerListString:before { + content: "Abc\00a0"; +} + +.customizerListUnique:before { + content: "Unq\00a0"; +} + +.customizerMask::selection, +.customizerNumeric::selection, +.customizerString::selection, +.customizerUnique::selection, +.customizerListNumeric::selection, +.customizerListString::selection, +.customizerListUnique::selection { + background: var(--cx-color-transparent); + color: var(--cx-color-black); + padding: 0; +} + +/* + * Search Customizer + */ + +input.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + height: 40px; + border-radius: 4px; + float: left; + clear: left; +} + +select.customizerSearch, +input.customizerSearch { + border: var(--cx-border); +} + +input.customizerSearch[type="color"] { + padding: 0; + overflow: hidden; +} + +input.customizerSearch:not([type="color"]) { + padding: 5px; +} + +select.customizerSearch { + margin: 9px; + background-color: var( --cx-background-widgets-color); + color: var(--cx-font-color); + cursor: default; + font: inherit; + padding-left: 3px; + border-radius: 4px; + float: left; + clear: left; +} + +span.customizerSearch { + color: var(--cx-font-color); + font: inherit; + line-height: 20px; + list-style: none; + position: relative; + margin: 5px 5px 0 15px; + float: left; + clear: left; +} + +span.customizerSearchSelect, +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + font: inherit; + line-height: 28px; + list-style: none; + position: relative; + height: 28px; + margin-top: 5px; + float: left; + clear: left; + left: 15px; +} + +span.customizerSearchSelect { + color: var(--cx-font-color); +} + +span.customizerSearchDescription, +span.customizerSearchCategory { + overflow: hidden; + text-overflow: ellipsis; + white-space: nowrap; +} + +span.customizerSearchDescription, +span.customizerSearchCategory, +span.customizerSearchCurrent { + color: var(--cx-background-color); +} + +span.customizerSearchSelect:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Select property ("; +} + +span.customizerSearchSelect:after { + color: var(--cx-font-color); + font-weight: bold; + content: ")"; +} + +span.customizerSearchDescription:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Description [ "; +} + +span.customizerSearchCategory:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Category [ "; +} + +span.customizerSearchDescription:after, +span.customizerSearchCategory:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +span.customizerSearchCurrent:before { + color: var(--cx-font-color); + font-weight: bold; + content: "Current Value [ "; +} + +span.customizerSearchCurrent:after { + color: var(--cx-font-color); + font-weight: bold; + content: " ]"; +} + +/* + * Password + */ + +div.CanvasXpressPassword { + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: normal 16px arial, tahoma, sans-serif; + margin: 2px 3px; + overflow: hidden; + padding: 1px 12px; + width: 200px; + height: 185px; + white-space: nowrap; + position: relative; + text-align: left; +} + +img.CanvasXpressPassword, +svg.CanvasXpressPassword { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgb(0 0 0 / 0%) !important; + box-sizing: border-box; + cursor: default; + float: right; + margin: 5px 0px 0px 0px !important; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressPasswordContainer { + box-sizing: border-box; + border-radius: 0px 0px 5px 5px; + color: var(--cx-font-color); + display: block; + left: 0px; + line-height: 100%; + position: relative; + top: 15px; + margin-top: 5px; + -ms-user-select: none; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +span.CanvasXpressPassword { + margin-bottom: 5px; + margin-left: 5px; + float: left; +} + +input.CanvasXpressPassword { + float: left; + margin-bottom: 5px; + padding: 5px; + border-radius: 5px; + border: 1px solid rgb(170, 170, 170); + width: 170px; +} + +/* + * CanvasXpressDrag + */ + +div.CanvasXpressDrag { + opacity: 0.75; + box-sizing: border-box; + filter: alpha(opacity=75); + background-color: rgba(255, 255, 255, 0.95); + position: absolute; +} + +div.CanvasXpressDragLayout { + opacity: 0.65; + box-sizing: border-box; + filter: alpha(opacity=65); + background-color: rgba(51, 122, 183, 0.65); + position: absolute; +} + +/* + * Tooltip + */ + +div.CanvasXpressTooltip { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + box-sizing: border-box; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; +} + +div.CanvasXpressTooltipInfo { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + margin: 2px 3px; + max-height: 800px; + overflow: hidden; + padding: 5px 6px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +/*****************************************************/ +/* Generators */ +/* A collection of Tooltips/Speech Bubbles */ +/* https://css-generators.com/tooltip-speech-bubble/ */ +/*****************************************************/ + +div.CanvasXpressTooltipInfoNone, +div.CanvasXpressTooltipInfoBottom, +div.CanvasXpressTooltipInfoTop, +div.CanvasXpressTooltipInfoLeft, +div.CanvasXpressTooltipInfoRight { + color: var(--cx-font-color); + font: var(--cx-font); + max-height: 800px; + padding: 10px; + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressTooltipInfoBottom { + border-radius: var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) / + var(--cx-callout-radius); + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 100%, + 50% calc(100% + var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 100% + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + var(--cx-callout-radius) max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / 0 0 + var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoBottom:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 100%, + 0 0, + 100% 0, + 100% 100%, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)), + 50% + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + calc(100% - var(--cx-callout-border-width)) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / 0 0 var(--cx-callout-size) 0; +} + +div.CanvasXpressTooltipInfoTop { + border-radius: min( + var(--cx-callout-radius), + 50% - var(--cx-callout-size) * tan(45deg) + ) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) / var(--cx-callout-radius); + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min(100%, 50% + var(--cx-callout-size) * tan(45deg)) 0, + 50% calc(-1 * var(--cx-callout-size)), + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) / var(--cx-callout-size) + 0 0 0; +} + +div.CanvasXpressTooltipInfoTop:before { + content: ""; + position: absolute; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 0 100%, + 100% 100%, + 100% 0, + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width), + 50% + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)), + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + var(--cx-callout-border-width) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0/ 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) var(--cx-callout-radius) max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) / var(--cx-callout-size) 0 0 0; +} + + +div.CanvasXpressTooltipInfoLeft { + border-radius: var(--cx-callout-radius) / + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius) var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)); + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + 0 min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(-1 * var(--cx-callout-size)) 50%, + 0 max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0/0 0 0 + var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoLeft::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 0 0, + 100% 0, + 100% 100%, + 0 100%, + var(--cx-callout-border-width) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc(var(--cx-callout-border-width) / sin(45deg) - var(--cx-callout-size)) + 50%, + var(--cx-callout-border-width) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0/0 0 0 var(--cx-callout-size); +} + +div.CanvasXpressTooltipInfoRight { + border-radius: var(--cx-callout-radius) / var(--cx-callout-radius) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + min(var(--cx-callout-radius), 50% - var(--cx-callout-size) * tan(45deg)) + var(--cx-callout-radius); + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + 100% min(100%, 50% + var(--cx-callout-size) * tan(45deg)), + calc(100% + var(--cx-callout-size)) 50%, + 100% max(0%, 50% - var(--cx-callout-size) * tan(45deg)) + ); + background: var(--cx-callout-border-color); + border-image: conic-gradient(var(--cx-callout-border-color) 0 0) fill 0 / + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) 0 + max(0%, 50% - var(--cx-callout-size) * tan(45deg)) var(--cx-callout-radius) / + 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressTooltipInfoRight::before { + content: ""; + position: absolute; + inset: 0; + z-index: -1; + padding: var(--cx-callout-border-width); + border-radius: inherit; + clip-path: polygon( + 100% 0, + 0 0, + 0 100%, + 100% 100%, + calc(100% - var(--cx-callout-border-width)) + min( + 100% - var(--cx-callout-border-width), + 50% + var(--cx-callout-size) * tan(45deg) - + var(--cx-callout-border-width) * tan(22.5deg) + ), + calc( + 100% + var(--cx-callout-size) - var(--cx-callout-border-width) / + sin(45deg) + ) + 50%, + calc(100% - var(--cx-callout-border-width)) + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + + var(--cx-callout-border-width) * tan(22.5deg) + ) + ); + background: var(--cx-callout-background-color) content-box; + border-image: conic-gradient(var(--cx-callout-background-color) 0 0) fill 0 / + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + 0 + max( + var(--cx-callout-border-width), + 50% - var(--cx-callout-size) * tan(45deg) + ) + var(--cx-callout-radius) / 0 var(--cx-callout-size) 0 0; +} + +div.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +img.CanvasXpressMousePosition, +svg.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + margin: 0px !important; + padding: 0px !important; + position: relative; + left: -13px; + top: -13px; + cursor: default; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +span.CanvasXpressMousePosition { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: move; + color: var(--cx-font-color); + font: var(--cx-font); + position: absolute; + left: 4px; + top: -20px; + white-space: nowrap; + text-align: left; + z-index: 1; +} + +div.CanvasXpressCanvasResizerClose { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAkAAAAOCAYAAAD9lDaoAAAAcUlEQVR42mM8e/bsfwYCgBGkSE9PD6eCS5cuIRSxsrIy/P79Gy4J42MoAgGQBDIbRRFMNwzATMVQhGwNVjehm/T582cwfevWLfxu+vTpO8Pt29ew++7Hjx8MvLy8mIpgAKTg/38WOB+uiGCIE1JAXUUA5WZpcWW3WYkAAAAASUVORK5CYII=); +} + +div.CanvasXpressCanvasResizerloading1 { + box-sizing: border-box; + background-image: 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5BvgPpYtzj9W+TNwUHDR4QqBAgr1bdIBzMlzCGgX8EFtTD1sBTPgQFRv/6YTAgDzgAJfP5eslDAAMFDTrS3Mmzp8+fQIMKHUq0qNGjSJMisYNR6YotCBAE9GPAgE6fEKJqnbiiQYQCYCmaePDgBNmyJc6mVUuC7Ai3AOC+ZWuipAStUQusGFDgawQFK+TOjYtWhFvBhwsTnlsWseITDfDibVoCAtivgFUINtxY8VnHiwdz/ty2MwoBkrVSJtEAbNjAjxeDnu25cOLaoU2sSa236wCrKglvpss5t/DHcuEO31z57laxTisniErganQSNldf3869u/fv4MOLH0++vHk/A5YQeISjQfBr6yTIl5/Sxp2/76sNmM9fuwsDESyAHzgJ8DdfbzN4JWCkBBFYd40DBsqXgA0DMIhMfsQUGGEENjRQIR4v7Rehfy9gWE18/DkEnh0RJELieTDGKOOMNAa1DlkS1Bceap894ICJUNjhCJAyFNAjWahAA8ECTKrow5FkIVDNMcgMAwSUzFnCAJMLvHiDBFBKWQ1LLgERAZRJBpVTiQ70eMBQDSigAHSnLYCAj2kCJYCcBjwz3h98EnkUM1adJ2iNiCaq6KKLhgAAIfkECQcAAAAsAAAAAGQAZAAABf8gII5kaZ5oqq5s675wLM90bd94ru987//AoHAYEywShIWAyKwtCMjEokmFCaJQwrLKVTWy0UZ3jCqAC+SfoCF+NQrIQrvFWEQU87RpQOgbYg0MMAwJDoUEeXoiX2Z9iT0LhgmTU4okEH0EZgNCk4WFEZYkX5kEEEJwhoaVoiIGmklDEJOSgq0jDAOnRBBwBba3wcLDxMXGx8jJysvMzUJbzgAGn7s2DQsFEdXLCg4HDt6cNhHZ2dDJAuDqhtbkBe+Pxgze4N8ON+Tu58jp6+A3DPJtU9aNnoM/OBrs4wYuAcJoPYBBnEixosWLGDNq3Mixo8ePIEOKxGHEjIGFKBj/DLyY7oDLA1pYKIgQQcmKBw9O4MxZYmdPnyRwjhAKgOhQoCcWvDyA4IC4FAHtaLvJM2hOo0WvVs3K9ehRrVZZeFsKc0UDmnZW/jQhFOtOt2C9ingLt+uJsU1dolmhwI5NFVjnxhVsl2tdwkgNby0RgSyCpyogqGWbOOvitlvfriVc2LKKli9jjkRhRNPJ0ahTq17NurXr17Bjy55NG0UDBQpOvx6AoHdTiTQgGICsrIFv3wdQvoCwoC9xZAqO+34Ow0DfBQ+VEZDeW4GNOgsWTC4WnTv1QQaAJ2vA9Hhy1wPaN42XWoD1Acpr69/Pv79/ZgN8ch5qBUhgoIF7BSMAfAT07TDAgRCON8ZtuDWYQwIQHpigKAzgpoCEOGCYoQQJKGidARaaYB12LhAwogShKMhAiqMc8JYDNELwIojJ2EjXAS0UCOGAywxA105EjgBBBAlMZdECR+LESmpQRjklagxE+YB6oyVwZImtCUDAW6K51mF6/6Wp5po2hAAAIfkECQcAAAAsAAAAAGQAZAAABf8gII5kaZ5oqq5s675wLM90bd94ru987//AoHAYE0AWC4iAyKwNCFDCoEmFCSJRQmRZ7aoaBWi40PCaUc/o9OwTNMqvhiE84LYYg4GSnWpEChEQMQ0MVlgJWnZ8I36AgHBAT4iIa4uMjo9CC5MECZWWAI2Oij4GnaefoEcFBYVCAlCIBK6gIwwNpEACCgsGubXAwcLDxMXGx8jJysvMZ7/KDAsRC5A1DQO9z8YMCQ4J39UzBhHTCtrDAgXf3gkKNg3S0hHhx9zs3hE3BvLmzOnd6xbcYDCuXzMI677RenfOGAR1CxY26yFxosWLGDNq3Mixo8ePIEOKHEmyZDEBAwz/GGDQcISAlhMFLHBwwIEDXyyOZFvx4MGJnj5LABU6lETPEUcBJEVa9MQAm1Ad0CshE4mCqUaDZlWqlatXpl9FLB26NGyKCFBr3lyxCwk1nl3F+iwLlO7crmPr4r17NqpNAzkXKMCpoqxcs0ftItaaWLFhEk9p2jyAlSrMukTjNs5qOO9hzipkRiVsMgXKwSxLq17NurXr17Bjy55Nu7ZtIoRWwizZIMGB3wR2f4FQuVjv38gLCD8hR8HVg78RIEdQnAUD5woqHjMgPfpv7S92Oa8ujAHy8+TZ3prYgED331tkp0Mef7YbJctv69/Pv7//HOlI0JNyQ+xCwHPACOCAmV4S5AfDAAhEKF0qfCyg14BANCChhAc4CAQCFz6mgwIbSggYKCGKmAOJJSLgDiggXiiBC9cQ5wJ3LVJ4hoUX5rMCPBIEKcFbPx5QYofAHKAXkissIKSQArGgIYfgsaGAki62JMCTT8J0Wh0cQcClkIK8JuaYEpTpGgMIjIlAlSYNMKaOq6HUpgQIgDkbAxBAAOd/gAYqKA0hAAAh+QQJBwAAACwAAAAAZABkAAAF/yAgjmRpnmiqrmzrvnAsz3Rt33iu73zv/8CgcChrQAYNotImiBQKi+RyCjM4nwOqtmV4Og3bcIpRuDLEaBNDoTjDGg1BWmVQGORDA2GfnZusCxFgQg17BAUEUn4jEYGNQwOHhhCLJFYREQpDEIZ7ipUCVgqfQAt7BYOVYkduqq6vsLGys7S1tre4ubq7UwIDBn04DAOUuwJ7CQQReDUMC8/FuXrJydE0Bs92uwvUBAnBNM7P4LcK3ufkMxDAvMfnBbw9oQsDzPH3+Pn6+/z9/v8AAwocSLCgwYO9IECwh9AEBAcJHCRq0aAOqRMPHmDMaCKjRhIeP47gKIIkyZEeU/8IgMiSABc2mlacRAlgJkebGnGizCmyZk8UAxIIHdoqRR02LGaW5AkyZFOfT5c6pamURFCWES+aCGWgKIqqN3uGfapzqU+xTFEIiChUYo+pO0uM3fnzpMm6VUs8jDixoVoIDBj6HUy4sOHDiBMrXsy4sWMSTSRkLCD4ltcZK0M+QFB5lgIHEFPNWKB5cq7PDg6AFh0DQem8sVaCBn0gQY3XsGExSD0bdI0DryXgks0bYg3SpeHhQj07HQzgIR10lmWAr/MYC1wjWDD9sffv4MOLR3j1m5J1l/0UkMCevXIgDRIcQHCAQHctENrrv55D/oH/B7ynnn7t2fYDAwD+R59zVmEkQCB7BvqgQIIAphdGBA9K4JILcbzQAID0/cfgFvk9aE0KDyFA34kp+AdgBK4MQKCAKEqg4o0sniBAAQBS9goEESQQQY4nJHDjjRGy0EBg/Rx55GFO3ngYAVFuWBiCRx4w4kENFKBiAVuOJ+aYZIoZAgAh+QQJBwAAACwAAAAAZABkAAAF/yAgjmRpnmiqrmzrvnAsz3Rt33iu73zv/8CgcChrMBoNotImUCwiiuRyCoNErhEIdduCPJ9arhgleEYWgrHaxIBAGDFkep1iGBhzobUQkdJLDAtOYUENEXx8fn8iBguOBkMNiImLJF6CA0MCBYh9lSMCEAYQikAMnBFwn2MCRquvsLGys7S1tre4ubq7vDqtpL5HvAIGBMYDeTTECgrJtwwEBcYEzjIMzKO7A9PGpUUGzN61EMbSBOIxoei0ZdOQvTuhAw3V8Pb3+Pn6+/z9/v8AAwocSBCQo0wFUwhI8KDhgwPrerUSUK8EAYcOD/CTRCABGhUMMGJ8d6JhSZMlHP+mVEkCJQCULkVgVFggQUcCC1QoEOlQQYqYMh+8FDrCZEyjRIMWRdoyaZ2bNhOoOmGAZ8OcKIAO3bqUpdKjSXk25XqiQdSb60JaJWlCK9OlZLeChetVrtMSm85iTXFRpMafdYfefRsUqEuYg7WWkGTTk4qFGB1EHEavIpuDCTNr3sy5s+fPoEOLHk063YCaCZD1mlpjk4TXrwtYjgWh5gLWMiDA3o3wFoQECRwExw2jwG7YCXDlFS58r4wEx187wMUgOHDgEWpEiC4h+a281h34pKE7em9b1YUDn7xiwHHZugKdYc/CSoIss0vr38+/v//RTRAQhRIC4AHLAAcgoCCkAuf50IACDkTYzCcCJLiggvTRAKEDB0TIFh0GXLjgeD4wwGGEESaQIREKiKggiT2YiOKJxI0xgIsIfKgCPS+YFWGHwq2oiYULHpCfCFZE+FELBszoQIN0NEDkATWaIACHB2TpwJEAEGOdaqsIMIACYLKwQJZoHuDcCkZweUsBaCKQJQGfEZBmlgV8ZkCCceqYWXVpUgOamNEYIOR/iCaq6KIAhAAAIfkECQcAAAAsAAAAAGQAZAAABf8gII5kaZ5oqq5s675wLM90bd94ru987//AoHBIExCPOMhiAUE6ZYLl0vissqJSqnWLGiwUA64Y1WiMfwKGmSgwgM+otsKwFhoWkYgBbmIo/gxEeXgLfCUNfwp1QQp4eoaHakdRelqQl5iZmpucnZ6foKGioz8LCA8IC5akOAcPr68Oq6CzMguwuAWjEBEFC4syDriwEqICvcg2w7iiDQXPBRHAMKfLD8bR0RE2t8u6ogzPEU01AsK4ErWdAtMzxxKvBeqs9PX29/j5+vv8/f7/AAMKNAEBwryBJAYgkMCwEMIUAxhKlOBQn4AB0cKsWDiRYTsRr07AMjGSBDOT10D/pgyJkmUXAjAJkEMBoaPEmSRTogTgkue1niGB6hwptAXMAgR8qahpU4JGkTpHBI06bGdRlSdV+lQRE6aCjU3n9dRatCzVoT/NqjCAFCbOExE7VoQ6tqTUtC2jbtW6967eE2wjPFWhUOLchzQNIl7MuLHjx5AjS55MubJlGQ3cKDj4kMEBBKARDKZ1ZwDnFQI+hwb9UZMAAglgb6uhcDXor6EUwN49GoYC26AJiFoQu3jvF7Vt4wZloDjstzBS2z7QWtPuBKpseA594LinAQYU37g45/Tl8+jTq19fmUF4yq8PfE5QPQeEAgkKBLpUQL7/BEJAkMCADiSwHx8NyIeAfH8IHOgDfgUm4MBhY0Dg34V7ACEhgQnMxocACyoon4M9EBfhhJdEcOEBwrkwQAQLeHcCAwNKSEB9VRzjHwHmAbCAA0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); + background-position: 50% 50%; + background-repeat: no-repeat; +} + +/********** + * Motion * + **********/ + +div.CanvasXpressMotion { + color: var(--cx-font-color); + font: var(--cx-font); +} + +img.CanvasXpressMotion, +svg.CanvasXpressMotion { + margin: 0px !important; + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; +} + +div.CanvasXpressMotionContainer { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAF0lEQVR42mNkAAJGNOLChQv/cRNYdAAA0dgUqRX/AM0AAAAASUVORK5CYII=); + background-repeat: repeat-x; +} + +div.CanvasXpressMotionCurrent { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAAlUlEQVR42mNkgIIDBw78ZyACODg4MCLzGWGa7e3tidHPcPDgQRRDGEGaTc0tidIMA6dPHocbAjZAV9eQJAMuXz5PZQM0NA1IMuDG9QuoBqioqJBkwJ07d1ANkJRWJ8mA509vUtkAUVFFkgx4/fo+qgG8fHIkGfD50yMqGgAiQIaws4oTpfnn75eoSRnGoCgzUQIoNgAAbjRcEcsB8BEAAAAASUVORK5CYII=); + background-repeat: no-repeat; + float: left; + height: 14px; + position: relative; + width: 14px; + z-index: 1000002; +} + +div.CanvasXpressMotionRange { + box-sizing: border-box; + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAOCAYAAADuQ3ZcAAAAFklEQVR42mNkAAJGNMKxcdd/3AQWHQAD/g7xOirtNAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + float: left; + height: 14px; + left: 0px; + top: -1px; + position: relative; + z-index: 1000001; +} + +/********* +* Marker * +**********/ + +div.CanvasXpressMarker { + box-sizing: border-box; + border: var(--cx-border); + border-radius: 5px; + background-color: var(--cx-background-widgets-color); + cursor: move; + font: var(--cx-font); + height: 502px; + width: 286px; + left: 0px; + line-height: 100%; + position: absolute; + top: 0px; + padding: 2px; +} + +/************* + * Toolbar * + *************/ + +div.CanvasXpressToolbarTop { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarTopContainer { + border: var(--cx-border); + border-radius: 0 0 8px 8px; + border-top: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer { + border: var(--cx-border); + border: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarTopOverContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopOverContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarTopContainer img.CanvasXpressToolbarTopImage, +div.CanvasXpressToolbarTopContainer svg.CanvasXpressToolbarTopImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarBottom { + position: absolute; + width: auto; + top: 0px; + left: 0px; + overflow: hidden; + display: flex; + justify-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarBottomContainer { + border: var(--cx-border); + border-radius: 8px 8px 0 0; + border-bottom: none; + width: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarBottomRound { + border-radius: 50%; + overflow: hidden; +} + +div.CanvasXpressToolbarBottomRound, +div.CanvasXpressToolbarBottomStripe { + cursor: pointer; + float: left; +} + +div.CanvasXpressToolbarLeft { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarLeftContainer { + border: var(--cx-border); + border-radius: 0 8px 8px 0; + border-left: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarLeftContainer img.CanvasXpressToolbarLeftImage, +div.CanvasXpressToolbarLeftContainer svg.CanvasXpressToolbarLeftImage { + background: var(--cx-color-transparent) !important; + border: 0px none !important; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px; +} + +div.CanvasXpressToolbarRight { + position: absolute; + top: 0px; + left: 0px; + overflow: hidden; + align-content: center; + z-index: 10000; +} + +div.CanvasXpressToolbarRightContainer { + border: var(--cx-border); + border-radius: 8px 0 0 8px; + border-right: none; + align-content: center; + height: auto; + padding: 1px; + background-color: var(--cx-background-widgets-color); +} + +div.CanvasXpressToolbarRightFont { + padding: 5px; + cursor: pointer; +} + +/************* + * Tooltip * + *************/ +div.CanvasXpressAltTooltip { + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 5px; + box-shadow: 0 0 5px var(--cx-color-transparent); + color: var(--cx-font-color); + font: var(--cx-font); + font-size: var(--cx-font-size); + line-height: 100%; + padding: 5px; + position: absolute; + display: none; + text-wrap: nowrap; + z-index: 1000000; +} + +/****************** + * Data Table DOE * + ******************/ + +table.CanvasXpressDataTableDOE { + border-spacing: 0 !important; + font-size: var(--cx-font-size) !important; + padding: 0 !important; + border: none !important; +} + +th.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + font-weight: bold !important; + padding-left: 5px !important; + padding-right: 5px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +td.CanvasXpressDataTableDOE { + padding: 0 !important; + font-size: var(--cx-font-size) !important; + padding-left: 5px !important; + padding-right: 18px !important; + height: 18px !important; + line-height: 18px !important; + white-space: nowrap !important; + overflow: hidden !important; + max-height: 18px !important; + border: none !important; +} + +tr.CanvasXpressDataTableDOE { + font-size: var(--cx-font-size) !important; +} + +/****************/ +/* Data Table */ +/****************/ + +div.CanvasXpressDataTableUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,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'); + background-size: contain; + background-repeat: no-repeat; + position: relative; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableContainer, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal, +div.CanvasXpressDataTableMask { + box-sizing: border-box; + position: absolute; +} + +div.CanvasXpressDataTable, +div.CanvasXpressDataTableToolbar, +div.CanvasXpressDataTableVertical, +div.CanvasXpressDataTableHorizontal { + color: var(--cx-font-color); + background-color: var(--cx-background-widgets-color) +} + +div.CanvasXpressDataTable { + border: var(--cx-border); + border-radius: 5px; + clear: both; + overflow: hidden; +} + +div.CanvasXpressDataTableToolbar { + border-bottom: var(--cx-border); + border-radius: 5px 5px 0px 0px; + height: 36px; + left: 0px; + line-height: 100%; + top: 0px; +} + +div.CanvasXpressDataTableContainer { + border-radius: 0px 0px 5px 5px; + display: block; + left: 0px; + line-height: 100%; +} + +div.CanvasXpressDataTableVertical { + overflow-x: hidden; + overflow-y: auto; + right: 6px; + top: 2px; + width: 16px; +} + +div.CanvasXpressDataTableHorizontal { + bottom: 12px; + height: 16px; + left: 2px; + overflow-x: auto; + overflow-y: hidden; +} + +div.CanvasXpressDataTableMask { + border: 0px; + top: 0px; + overflow: hidden; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage, +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + background: var(--cx-color-transparent) !important; + border-radius: 5px; + padding: 2px; + box-shadow: 0 0 0px var(--cx-color-transparent) !important; + cursor: pointer; + float: right; + margin: 5px 8px 0px 0px !important; +} + +img.CanvasXpressDataTableToolbarImage, +svg.CanvasXpressDataTableToolbarImage { + border: var(--cx-border) !important; +} + +img.CanvasXpressDataTableToolbarImageNB, +svg.CanvasXpressDataTableToolbarImageNB { + border: none !important; +} + +img.CanvasXpressDataTableToolbarImageLogo, +svg.CanvasXpressDataTableToolbarImageLogo { + border: none !important; + float: left; + margin: 5px 0px 0px 10px !important; +} + + +img.CanvasXpressDataTableVertical { + max-height: unset !important; + height: revert-layer !important; +} + +img.CanvasXpressDataTableHorizontal { + max-width: unset !important; +} + +table.CanvasXpressDataTable { + border: 0px; + border-spacing: 1px; + color: var(--cx-font-color); + left: 1px; + position: absolute; + opacity: 0.95; + table-layout: fixed; + top: 1px; +} + +th.CanvasXpressTableCellHead, +th.CanvasXpressTableCellHeadActive { + border-top: none; + border-bottom: var(--cx-border-transparent); + border-left: none; + border-right: var(--cx-border-transparent); + font-weight: normal; + opacity: 0.95; + padding: 2px; + vertical-align: middle; +} + +tr > th.CanvasXpressTableCell:last-child, +tr > th.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +th.CanvasXpressTableCellHead { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +th.CanvasXpressTableCellHeadActive { + background: var(--cx-background-accent-color); + font: var(--cx-x-large-font); + font-weight: normal; + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHead, +a.CanvasXpressTableCellHeadActive { + cursor: pointer; + position: absolute; + right: 8px; + white-space: normal; + text-decoration: none; + font-style: normal; + width: 14px; +} + +a.CanvasXpressTableCellHead { + color: var(--cx-font-color); +} + +a.CanvasXpressTableCellHeadActive { + color: var(--cx-background-color); +} + +td.CanvasXpressTableCell, +td.CanvasXpressTableCellActive { + border-top: none !important; + border-bottom: var(--cx-border-transparent); + border-left: none !important; + border-right: var(--cx-border-transparent); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + padding: 2px !important; + vertical-align: middle; +} + +tr > td.CanvasXpressTableCell:last-child, +tr > td.CanvasXpressTableCellActive:last-child { + border-right: var(--cx-border-transparent); +} + +div.CanvasXpressTableCell, +div.CanvasXpressTableCellLink { + box-sizing: border-box; + color: var(--cx-font-color); + margin: 2px 2px 1px 5px; + overflow: hidden; + position: relative; + text-align: left; + white-space: pre-wrap; + word-break: break-word; +} + +div.CanvasXpressTableCell:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressTableCellLink:hover { + background-color: var(--cx-background-hover-color); + text-decoration: underline var(--cx-border); + cursor: pointer; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell, +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + border-radius: 5px; +} + +th.CanvasXpressTableCellHead div.CanvasXpressTableCell { + /* border: var(--cx-border-transparent); */ +} + +th.CanvasXpressTableCellHeadActive div.CanvasXpressTableCell { + /* border: var(--cx-border) */ +} + +/***************/ +/* Data Filter */ +/***************/ + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar, +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive, +select.CanvasXpressDataFilterContainerString { + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilter, +div.CanvasXpressDataFilterToolbar { + box-sizing: border-box; + line-height: 100%; + margin: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterToolbar { + border: var(--cx-border) !important; + border-radius: 4px; + left: 0px; + opacity: 0.95; + top: 0px; +} + +span.CanvasXpressDataFilterToolbarText, +span.CanvasXpressDataFilterText, +span.CanvasXpressDataFilterTextActive { + left: 8px; + line-height: 100%; + position: relative; + top: 9px; + background-repeat: no-repeat; + background-position: -0px; +} + +select.CanvasXpressDataFilterContainerString { + background-color: var(--cx-background-widgets-color); + margin-left: 3px; + margin-bottom: 3px; +} + +div.CanvasXpressDataFilterContent { + box-sizing: border-box; + background-color: var(--cx-background-widgets-color); + border: var(--cx-border); + border-radius: 0px 0px 4px 4px; + border-top: 0px; + font-family: var(--cx-font-family); + font-size: var(--cx-x-large-font-size); + color: var(--cx-font-color); + overflow-y: auto; + overflow-x: hidden; + padding: 2px; +} + +input[type=checkbox].CanvasXpressCheckbox { + accent-color: var(--cx-background-accent-color); + border-radius: 5px; + height: 14px; + width: 14px; + margin: 2px; +} + +label.CanvasXpressCheckboxLabel { + width: 220px; + text-overflow: ellipsis; + white-space: nowrap; + overflow-x: hidden; + margin: 0 0 0 3px !important; +} + +div.CanvasXpressDataFilterContainer, +div.CanvasXpressDataFilterContainerMask, +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable { + box-sizing: border-box; +} + +div.CanvasXpressDataFilterContainer { + border: 0px; + left: 0px; + margin: 0px; + padding: 0px; + position: absolute; +} + +div.CanvasXpressDataFilterContainerMask { + border: var(--cx-border); + margin: 5px; + overflow-x: hidden; + overflow-y: scroll; +} + +div.CanvasXpressDataFilterContainerItem, +div.CanvasXpressDataFilterContainerItemSelected { + height: 20px; + padding: 1px 0px 0px 1px; + overflow: hidden; + white-space: nowrap; +} + +div.CanvasXpressDataFilterContainerItemSelected, +div.CanvasXpressDataFilterContainerHoverable:hover { + background-color: var(--cx-background-hover-color); +} + +div.CanvasXpressDataFilterContainerHoverable { + border: var(--cx-border); + border-radius: 5px; + margin: 2px; + margin-bottom: 4px; +} + +div.CanvasXpressDataFilterHead, +div.CanvasXpressDataFilterHeadActive { + border: var(--cx-border); + border-radius: 4px; + box-sizing: border-box; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 38px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + text-align: left; + vertical-align: middle; +} + +div.CanvasXpressDataFilterHeadActive { + background:var(--cx-background-hover-color); + border-bottom: var(--cx-border-transparent) !important; + border-radius: 4px 4px 0px 0px; +} + +div.CanvasXpressDataFilterContainerTicks { + display: flex; + justify-content: space-between; + padding: 0px 10px; + height: 18px; +} + +span.CanvasXpressDataFilterContainerTicks, +span.CanvasXpressDataFilterContainerTicksLong { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + line-height: 10px; + margin-bottom: 10px; +} + +span.CanvasXpressDataFilterContainerTicks { + height: 5px; +} + +span.CanvasXpressDataFilterContainerTicksLong { + height: 10px; +} + +img.CanvasXpressDataFilterToolbarImage, +svg.CanvasXpressDataFilterToolbarImage { + border: var(--cx-border) !important; + border-radius: 5px !important; + padding: 2px; +} + +img.CanvasXpressDataFilterToolbarImageNB, +svg.CanvasXpressDataFilterToolbarImageNB { + border: none !important; +} + +span.CanvasXpressDataFilterText { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASElEQVR42mNkoBAwUt2A/0AAlgACsg0A6QWZQ4whOA2AsgkagtcAYgwhaAAhQ4gyAJ8htHcBRWFAUSxQlA7AEuSmRFLBwBsAAMDpRxF7e4BAAAAAAElFTkSuQmCC); +} + +span.CanvasXpressDataFilterTextActive { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAASUlEQVR42mNkoBAwjhqAMOA/EBCtCQiwGoAkjhOA7MFqADGGoGvGGga4DMGmGWcgohuCSzNOA5ANwacZrwFIhuBVM4gS0oAZAAD1oisRsByngAAAAABJRU5ErkJggg==); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow, +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + box-sizing: border-box; + margin: 5px; + overflow: hidden; +} + +div.CanvasXpressDataFilterContainerMaskNoOverflow { + border: var(--cx-border); +} + +div.CanvasXpressDataFilterContainerMaskNoOverflowOut { + border: none; +} + +input.CanvasXpressDateFilterContainerInputLeft { + float: left; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +input.CanvasXpressDateFilterContainerInputRight { + float: right; + margin: 10px; + border: none; + border-radius: 5px; + font-size: small; + color: var(--cx-background-color); +} + +/***************/ +/* Toggle */ +/***************/ + +div.CanvasXpressToggle { + border: none; + margin: 5px; + height: 18px; +} + +label.CanvasXpressToggle { + cursor: pointer; +} + +div.CanvasXpressToggleSwitch { + display: inline-block; + background: rgb(204, 204, 204); + border-radius: 16px; + width: 28px; + height: 18px; + position: relative; + vertical-align: middle; + transition: background 0.25s; +} + +div.CanvasXpressToggleSwitch:before, +div.CanvasXpressToggleSwitch:after { + content: ""; +} + +div.CanvasXpressToggleSwitch:before { + display: block; + background: linear-gradient(to bottom, rgb(255, 255, 255) 0%, rgb(238, 238, 238) 100%); + border-radius: 50%; + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.25); + width: 14px; + height: 14px; + position: absolute; + top: 2px; + left: 2px; + transition: left 0.25s; +} + +label.CanvasXpressToggle:hover div.CanvasXpressToggleSwitch:before { + background: linear-gradient(to bottom, rgb(255, 255, 255)0%, rgb(255, 255, 255)100%); + box-shadow: 0 0 0 1px rgba(0, 0, 0, 0.5); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch { + background: var(--cx-background-color); +} + +input.CanvasXpressToggle:checked+div.CanvasXpressToggleSwitch:before { + left: 12px; +} + +input.CanvasXpressToggle { + position: absolute; + visibility: hidden; +} + +span.CanvasXpressToggle { + margin-left: 5px; + margin-right: 5px; + position: relative; +} + +/****************/ +/* Range Slider */ +/****************/ + +div.CanvasXpressRangeSliderContainer { + border: none; + margin: auto; + height: 110px; +} + +div.CanvasXpressRangeSliderContainerTop { + height: 18px; + margin: 5px; + position: relative; + display: flex; +} + +span.CanvasXpressRangeSliderContainerTop { + border: none; +} + +div.CanvasXpressRangeSliderContainerBottom { + height: 80px; + position: relative; +} + +div.CanvasXpressRangeSliderInput { + position: relative; + z-index: 10001; + height: 22px; + margin: 8px 0; +} + +input.CanvasXpressRangeSliderMin, +input.CanvasXpressRangeSliderMax { + color: var(--cx-background-color); + border: 1px solid var(--cx-background-widgets-color); + border-radius: 5px; + font: var(--cx-font); + margin-bottom: 2px; + line-height: 100%; + width: 60px; +} + +input.CanvasXpressRangeSliderMin { + float: left; + margin-left: 1px; +} + +input.CanvasXpressRangeSliderMax { + float: right; + margin-right: 1px; + text-align: right; +} + +div.CanvasXpressRangeSlider { + position: relative; + z-index: 10001; + height: 8px; + margin: 0 15px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderTrack { + position: absolute; + z-index: 10001; + left: 0; + right: 0; + top: 0; + bottom: 0; + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderRange { + background-color: var(--cx-background-color); + position: absolute; + z-index: 10002; + left: 0%; + right: 0%; + top: 0; + bottom: 0; + border-radius: 5px; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + position: absolute; + z-index: 10003; + width: 18px; + height: 18px; + border-radius: 50%; + transition: box-shadow .3s ease-in-out; +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + background-color: var(--cx-background-color); + box-shadow: 0 0 0 0 var(--cx-background-hover-color); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft { + left: 0%; + transform: translate(-15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight { + right: 0%; + transform: translate(15px, -5px); +} + +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbLeft:hover, +div.CanvasXpressRangeSlider>div.CanvasXpressRangeSliderThumbRight:hover { + box-shadow: 0 0 0 10px var(--cx-background-hover-color); +} + +input[type=range].customizerRightItemRangeSelect { + -webkit-appearance: none; + appearance: none; + width: 100%; + height: 8px; + border-radius: 5px; + background: var(--cx-color-extra-light-gray); + outline: none; + opacity: 1; +} + +input[type=range].customizerRightItemRangeSelect::-webkit-slider-thumb { + -webkit-appearance: none; + appearance: none; + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range].customizerRightItemRangeSelect::-moz-range-thumb { + width: 15px; + height: 15px; + border-radius: 50%; + background: var(--cx-background-color); + cursor: pointer; +} + +input[type=range] { + position: absolute; + pointer-events: none; + -webkit-appearance: none; + z-index: 10002; + height: 10px; + width: 100%; + opacity: 0; +} + +input[type=range]::-webkit-slider-thumb { + pointer-events: all; + width: 30px; + height: 30px; + border-radius: 0; + border: 0 none; + background-color: red; + -webkit-appearance: none; +} + +div.CanvasXpressRangeSliderTicks, +div.CanvasXpressRangeSliderTicksLog { + display: flex; + padding: 0px 10px; + height: 18px; + margin-top: 10px; +} + +div.CanvasXpressRangeSliderTicks { + justify-content: space-between; +} + +span.CanvasXpressRangeSliderTicksLong, +span.CanvasXpressRangeSliderTicks { + position: relative; + display: flex; + justify-content: center; + width: 1px; + background: var(--cx-background-color); + margin-bottom: 10px; +} + +span.CanvasXpressRangeSliderTicksLong { + color: var(--cx-background-color); + height: 10px; + line-height: 35px; + font-size: small; +} + +span.CanvasXpressRangeSliderTicks { + height: 5px; + line-height: 10px; +} + +/** + * Input type number + */ + +input[type=number]::-webkit-inner-spin-button { + -webkit-appearance: none; +} + +/***************/ +/* Scrollbars */ +/***************/ + +/* All scrollbar buttons*/ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-button, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-button, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-button,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-button, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-button, +div.CanvasXpressDataExplorer::-webkit-scrollbar-button, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-button, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-button, +select.CanvasXpressConfigurator::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-button, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-button, +select.CanvasXpressSlider::-webkit-scrollbar-button, +div.cX-bin-name-container::-webkit-scrollbar-button { + width: 4px; + height: 4px; +} + +/* Tracks can be of two different colors */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track, +select.CanvasXpressConfigurator::-webkit-scrollbar-track, +select.CanvasXpressSlider::-webkit-scrollbar-track { + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track, +div.cX-bin-name-container::-webkit-scrollbar-track { + background-color: rgb(245, 245, 245); +} + +/* All tracks -hovers */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-track:hover, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-track:hover, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-track:hover,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-track:hover, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-track:hover, +div.CanvasXpressDataExplorer::-webkit-scrollbar-track:hover, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-track:hover, +select.CanvasXpressConfigurator::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-track:hover, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-track:hover, +select.CanvasXpressSlider::-webkit-scrollbar-track:hover, +div.cX-bin-name-container::-webkit-scrollbar-track:hover { + background-color: var(--cx-background-hover-color); + border-radius: 8px; +} + +/* scrollbar background could be of two different colors but match the style tracks above */ + +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar, +select.CanvasXpressConfigurator::-webkit-scrollbar, +select.CanvasXpressSlider::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(255, 255, 255); +} + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar, +div.CanvasXpressDataTableVertical::-webkit-scrollbar, +div.CanvasXpressDataExplorer::-webkit-scrollbar, +div.CanvasXpressDataCustomizer::-webkit-scrollbar, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar, +div.cX-bin-name-container::-webkit-scrollbar { + width: 8px; + height: 8px; + background-color: rgb(245, 245, 245); +} + +/* All tracks thumbs */ + +div.CanvasXpressDataTableHorizontal::-webkit-scrollbar-thumb, +div.CanvasXpressDataTableVertical::-webkit-scrollbar-thumb, +/*div.CanvasXpressDataFilterContent::-webkit-scrollbar-thumb,*/ +div.CanvasXpressDataFilterContainerMask::-webkit-scrollbar-thumb, +div.CanvasXpressDataFilterContainerMaskNoOverflow::-webkit-scrollbar-thumb, +div.CanvasXpressDataExplorer::-webkit-scrollbar-thumb, +div.CanvasXpressDataCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressSearchCustomizer::-webkit-scrollbar-thumb, +select.CanvasXpressConfigurator::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExample::-webkit-scrollbar-thumb, +div.CanvasXpressConfiguratorExampleContent::-webkit-scrollbar-thumb, +select.CanvasXpressSlider::-webkit-scrollbar-thumb, +div.cX-bin-name-container::-webkit-scrollbar-thumb { + background-color: var(--cx-background-contrast-color); + border-radius: 8px; + border: none; +} + +div.CanvasXpressDataFilter::selection, +div.CanvasXpressDataFilterToolbar::selection { + background: var(--cx-color-transparent); + color: var(--cx-font-color); +} + +div.CanvasXpressDataFilterContainerItem::selection { + background: var(--cx-color-transparent); + color: var(--cx-background-color); +} + +/* + * Menu + */ + +div.CanvasXpressLink { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/gif;base64,R0lGODlh+gABAIcAAOLj4/Dw8P///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAAAAP8ALAAAAAD6AAEAAAgfAAMIHEiwoMGBAAQcXMiwocOHECNKnEixosWLGCMGBAA7); + background-repeat: repeat-y; + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-font); + line-height: 100%; + margin: 0px; + opacity: 0.95; + padding: 0px; + position: absolute; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + position: relative; +} + +input.CanvasXpressTabMenuConfigurator { + display: none; +} + +input:not(:checked).CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + display: none; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + float: left; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + float: right; + width: 100%; + margin: 22 0 0 -100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + cursor: pointer; + -moz-user-select: none; + -ms-user-select: none; + -webkit-user-select: none; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + padding: 0.5px; + border: 1px solid rgb(238, 238, 238); + border-radius: 4px; + background: rgb(255, 255, 255) +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + box-sizing: border-box; + margin: 0; + padding: 0.5px; + overflow: hidden; + font: var(--cx-font); + color: var(--cx-font-color); + line-height: 100%; +} + +section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator>label.CanvasXpressTabMenuConfigurator { + display: block; + padding: 5px; + border: 1px solid rgb(238, 238, 238); + border-bottom: none; + border-top-left-radius: 4px; + border-top-right-radius: 4px; + background: rgb(255, 255, 255) +} + +input:first-child.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + padding-left: 0; +} + +section.CanvasXpressTabMenuConfigurator>div.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 1; +} + +input:checked.CanvasXpressTabMenuConfigurator+section.CanvasXpressTabMenuConfigurator>h1.CanvasXpressTabMenuConfigurator { + position: relative; + z-index: 2; +} + +div.CanvasXpressMenu { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + border-radius: 3px; + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 100%; + margin: 0px; + padding: 0px; + position: absolute; + opacity: 0.95; + -moz-box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; +} + +ul.CanvasXpressList { + background: transparent; + border: 0px none; + cursor: default; + list-style: none; + margin: 0px; + overflow: auto; + padding: 2px !important; + height: calc(100% - 100px); +} + +li.CanvasXpressListItemSep { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + height: 100%; + line-height: 1px; + list-style: none; + margin: 0px; + padding: 1px; + /* width: 100%; */ + white-space: nowrap; +} + +input.CanvasXpressListItem { + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 100%; + list-style: none; + margin: 0px; + padding: 1px; + white-space: nowrap; +} + +input[type=file] { + display: block; +} + +div.CanvasXpressListItem { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; +} + +li.CanvasXpressListItem { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemActive { + background: rgba(83, 105, 255, 0.1); + border-color: rgb(83, 105, 255); + border-style: solid; + border-width: 1px 0px; + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + height: 100%; + line-height: 100%; + list-style: none; + margin: 0px; + padding: 0px; + width: 100%; + white-space: nowrap; + text-align: left; +} + +li.CanvasXpressListItemScrollTop { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAARUlEQVR42mNkQAMXL178z0Ah0NfXZ0Tmo3BAFkhLS+M1IDw8kmHlyuV41Tx9+hTFIjiDWAtggBSLGMmxgFSLGKkRB4QAAILWJXgE49MrAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollTopActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAbUlEQVR42mNkQAOHb/38z0AhsFVjZ0Tmo3BAFmjIsOHULMLJwKDs1sFwd1cFw5vvuC258eQXikWMyBYoSOC2QIYXYgEMgCx68hm3RQ9eICxihFkgzI/bAk0xVAuQLbr+CrdFbz9CLGKkRhwQAgBYqyubRxy5uAAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottom { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAASUlEQVR42mO8ePHifwYaA0YQAbJIWloar8Lw8EgMsZUrl+PV8/TpUwZ9fX1GRpgAqRYRawHcJ6RaRIoFGJbALCIcyvgBsgUgAACiryV42XltywAAAABJRU5ErkJggg==); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 0px; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollBottomActive { + background-color: rgb(219, 236, 244); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABkAAAAFCAYAAACw/UeDAAAAcklEQVR42mM8fOvnfwYaA0YQAbJImJ8NpyJNMQYGZbcODPG7uyoYrr/Cbfjbj78YbNXYGRlhAiCLFCRwWyTDi2oRyIInn3Fb8OAFxAK4T5At0pDBbZEIJ8QikAVvvuO24MYThAUYlsAsIjPo4QDZAhAAAK/AK5vjVTSgAAAAAElFTkSuQmCC); + background-repeat: no-repeat; + background-position: 50% 50%; + border: 1px; + border-color: rgb(170, 204, 246); + border-style: solid; + cursor: pointer; + height: 9px; + line-height: 9px; + width: 100%; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +li.CanvasXpressListItemScrollSearch { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 1px; + width: 100%; +} + +input.CanvasXpressListItemScrollSearch { + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 3px; + outline-style: none; + outline-width: 0px; + padding-left: 5px; + width: 93%; +} + +a.CanvasXpressListItemA { + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAActive { + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrow { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgba(0, 0, 0, 0); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none; + white-space: nowrap; +} + +a.CanvasXpressListItemAArrowActive { + background: url(data:image/gif;base64,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) no-repeat scroll right 50% transparent; + border-color: rgb(170, 204, 246); + border-style: solid; + border-width: 0px 1px; + color: var(--cx-font-color); + cursor: pointer; + display: block; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin: 0px; + outline-style: none; + outline-width: 0px; + padding: 3px 3px 3px 38px; + position: relative; + text-decoration: none !important; + white-space: nowrap; +} + +img.CanvasXpressListIcon, +svg.CanvasXpressListIcon { + background-position: center; + border: 0px none !important; + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + height: 24px; + line-height: 24px; + list-style: none; + left: 3px; + margin: 0px !important; + padding: 0px; + position: absolute; + top: 3px; + vertical-align: top; + width: 24px; + white-space: nowrap; + background: rgba(0, 0, 0, 0) !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; +} + +span.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + margin-right: 10px; + white-space: nowrap; +} + +input.CanvasXpressListItemText { + color: var(--cx-font-color); + cursor: pointer; + font: var(--cx-x-large-font); + line-height: 24px; + list-style: none; + white-space: nowrap; +} + +span.CanvasXpressListItemTextShort { + color: var(--cx-font-color); + cursor: pointer; + float: right; + font: var(--cx-small-font-italic); + line-height: 24px; + list-style: none; + margin-left: 10px; + white-space: nowrap; +} + +span.CanvasXpressListItemTextSep { + background-color: rgb(224, 224, 224); + border-bottom: 1px solid; + border-bottom-color: rgb(255, 255, 255); + cursor: default; + display: block; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + font-size: 1px; + line-height: 1px; + list-style: none; + margin: 2px 3px; + overflow: hidden; + white-space: nowrap; +} + +table.CanvasXpressListItemTable { + border: collapse; + line-height: 20px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + padding-left: 3px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; +} + +img.CanvasXpressToolbarHelp, +svg.CanvasXpressToolbarHelp { + background: rgba(0, 0, 0, 0) !important; + border: 0px none !important; + box-shadow: 0 0 0px rgba(0, 0, 0, 0) !important; + cursor: default; + float: right; + margin: 0px 0px 0px 2px !important; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +div.CanvasXpressToolbarHelp { + box-sizing: border-box; + background-color: rgba(255, 255, 255, 0.95); + border-radius: 5px; + border: 1px solid rgb(83, 105, 255); + box-shadow: rgba(154, 154, 154, 0.2) 3px 3px; + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +p.CanvasXpressToolbarHelp { + cursor: default; + font: var(--cx-x-large-font); + color: var(--cx-font-color); + line-height: 24px; + margin: 0px; + padding: 5px 5px 5px 20px; +} + +div.CanvasXpressForm { + box-sizing: border-box; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgba(255, 255, 255, 0.95); + color: var(--cx-font-color); + cursor: move; + font: var(--cx-x-large-font); + margin: 8px; + padding: 8px; + position: absolute; + white-space: nowrap; +} + +input.CanvasXpressFormButton { + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mP88OHDf0aSiGfPntGaAAAL8XAJa+SuYgAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 5px 5px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormButtonActive { + background-color: rgba(255, 255, 255, 0.95); + background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAAeCAYAAADtlXTHAAAAFklEQVR42mN89fnvf0aSiBvPf9GaAABVL3D5nF6uqAAAAABJRU5ErkJggg==); + background-repeat: repeat-x; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px 5px 0px 0px; + color: var(--cx-font-color); + cursor: pointer; + float: left; + height: 22px; + margin-top: 2px; + overflow: hidden; + opacity: 0.95; + padding: 2px; + vertical-align: middle; + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + -ms-user-select: none; +} + +input.CanvasXpressFormText { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + padding-left: 3px; +} + +form.CanvasXpressFormForm { + background-color: rgba(255, 255, 255, 0.95); + border: 1px solid rgb(83, 105, 255); + color: var(--cx-font-color); + cursor: default; + font: var(--cx-x-large-font); + line-height: 24px; + margin: 8px; + overflow: auto; + padding-left: 3px; +} + +div.CanvasXpressConfiguratorColor { + box-sizing: content-box; + border: 1px solid rgb(83, 105, 255); + font: var(--cx-font); + color: rgb(34, 34, 34); + line-height: 18px; +} + +div.CanvasXpressConfiguratorColorMain { + box-sizing: content-box; + background-image: url(data:image/png;base64,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); + background-repeat: no-repeat; + box-sizing: content-box; + border: none; + font: var(--cx-font); + color:var(--cx-font-color); + float: left; + cursor: crosshair; +} + +div.CanvasXpressConfiguratorColorExtra { + box-sizing: content-box; + background-image: url(data:image/gif;base64,R0lGODlhDwAPAKEBAAAAAP///////////yH5BAEKAAIALAAAAAAPAA8AAAIklB8Qx53b4otSUWcvyiz4/4AeQJbmKY4p1HHapBlwPL/uVRsFADs=); + background-repeat: no-repeat; + border: none; + font: var(--cx-font); + color: var(--cx-font-color); + cursor: crosshair; + overflow: hidden; +} + +/* + * Slider + */ + +div.CanvasXpressSlider { + background: rgba(0, 0, 0, 0); + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 50%; + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSliderRemote { + background: rgba(0, 0, 0, 0); + height: 36px; + position: absolute; + margin-left: 3px; + margin-right: 3px; + width: 36px; +} + +div.CanvasXpressSlider:hover { + background: rgba(0, 0, 0, 0.4); +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSlider { + width: 20px; + height: 20px; + } +} + +div.CanvasXpressSliderLeft { + left: -50px; +} + +div.CanvasXpressSliderLeft img, +div.CanvasXpressSliderLeft svg { + margin: 5px 5px 3px 3px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderLeft { + left: -25px; + } + + div.CanvasXpressSliderLeft img, + div.CanvasXpressSliderLeft svg { + margin: -4px 0px 0px -2px; + } +} + +div.CanvasXpressSliderRight { + right: -50px; +} + +div.CanvasXpressSliderRight img, +div.CanvasXpressSliderRight svg { + margin: 5px 3px 3px 8px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderRight { + right: -25px; + } + + div.CanvasXpressSliderRight img, + div.CanvasXpressSliderRight svg { + margin: -4px -2px 0px 2px; + } +} + +div.CanvasXpressSliderDotsContainer { + top: 25%; +} + +div.CanvasXpressSliderDots { + width: 10px; + height: 10px; +} + +@media screen and (max-width: 480px) { + div.CanvasXpressSliderDots { + width: 5px; + height: 5px; + margin-left: 1px; + margin-right: 1px; + } +} + +input.CanvasXpressSlider, +select.CanvasXpressSlider { + padding: 2px 3px 2px 2px; + cursor: default; + color: var(--cx-font-color); + border-left: none; + border-right: none; + border-top: none; + border-bottom: 1px solid rgb(83, 105, 255); + background: rgba(0, 0, 0, 0); + width: 100%; + max-Width: 100%; + line-height: 22px; + margin: 0; +} + +input.CanvasXpressSlider:focus, +select.CanvasXpressSlider:focus { + outline: 0; +} + + +/* +@media (max-width: 480px) { + img { + height : 16px; + width : 16px; + } +} +*/ + + +/* + * Parent Node + */ + +div.CanvasXpress-ParentNode { + /* + border: 1px solid 'rgba(0,0,0,0)' + margin: auto; + display: table; + padding: 0; + */ + -moz-transform: none; + -webkit-transform: none; + -o-transform: none; + -ms-transform: none; + transform: none; +} + +/* + * CanvasXpress Tab Panel + */ + +div.CanvasXpressTabPanel { + font: var(--cx-x-large-font); + float: left; + width: 100% +} + +/* Customizer */ + +div.CanvasXpressTabPanelCustomizer { + position: relative; + border-bottom: 1px solid rgb(238, 238, 238); + top: -10px; + overflow: hidden; +} + +div.CanvasXpressTabPanelRibbonSection { + width: fit-content; + position: relative; + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + padding-left: 8px; + padding-top: 5px; + margin-top: 12px; + float: left; +} + +span.CanvasXpressTabPanelRibbonSection { + margin-left: -3px; + background-color: white; + position: absolute; + float: left; + top: -14px; + padding: 3px; +} + +div.CanvasXpressTabPanelRibbon { + float: left; + margin-right: 10px; +} + +span.CanvasXpressTabPanelRibbon { + color: var(--cx-font-color); + font: var(--cx-x-large-font); + line-height: 28px; + list-style: none; + white-space: nowrap; + position: relative; + height: 28px; +} + +div.CanvasXpressTabPanelRibbonContainer { + border: 1px solid rgb(83, 105, 255); + border-radius: 5px; + background-color: rgb(238, 238, 238); +} + +svg.CanvasXpressTabPanelRibbon { + float: left; + border: 1px solid rgb(83, 105, 255); + margin-left: 5px; + margin-top: 5px; + padding: 2px; + border-radius: 5px; + background-color: rgb(255, 255, 255); +} + +svg.CanvasXpressTabPanelRibbon:hover { + background: rgba(83, 105, 255, 0.1) +} + +/* Header */ + +div.CanvasXpressTabPanelHeader { + font: var(--cx-x-large-font); + border-bottom: 2px solid rgb(83, 105, 255); + height: 38px; + width: 100%; + float: left; +} + +div.CanvasXpressTabPanelHeaderTab { + font: var(--cx-x-large-font); + margin-left: 20px; + margin-right: 20px; + float: left; +} + +input.CanvasXpressTabPanelHeader { + border-width: 1px 1px 0 1px; + border-color: rgb(83, 105, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +input.CanvasXpressTabPanelHeaderActive { + border-bottom-width: 2px; + border-left-color: rgb(83, 105, 255); + border-top-color: rgb(83, 105, 255); + border-right-color: rgb(83, 105, 255); + border-bottom-color: rgb(255, 255, 255); + border-style: solid; + border-radius: 5px 5px 0 0; + padding: 8px; + font: var(--cx-x-large-font); + max-width: 100px; + outline: none; + text-align: center; +} + +/* Content */ + +div.CanvasXpressTabPanelContent { + display: block; + float: left; + width: 100%; + position: relative; +} + +/* Rows */ + +div.CanvasXpressRow { + clear: both; + display: flex; + flex-wrap: wrap; + float: left; + width: 100%; +} + +div.CanvasXpressRow:before, +div.CanvasXpressRow:after { + content: " "; + display: table; +} + +div.CanvasXpressRow:after { + clear: both; +} + +div.CanvasXpressRowColumnFull, +div.CanvasXpressRowColumnTwoThird, +div.CanvasXpressRowColumnThreeFourth, +div.CanvasXpressRowColumnFourFifth, +div.CanvasXpressRowColumnFiveSixth, +div.CanvasXpressRowColumnHalf, +div.CanvasXpressRowColumnThird, +div.CanvasXpressRowColumnFourth, +div.CanvasXpressRowColumnFifth, +div.CanvasXpressRowColumnSixth { + float: left; + /* + padding-left: 1rem; + padding-right: 1rem; + */ + -moz-box-sizing: border-box; + -webkit-box-sizing: border-box; + box-sizing: border-box; +} + +div.CanvasXpressRowColumnFull:hover, +div.CanvasXpressRowColumnTwoThird:hover, +div.CanvasXpressRowColumnThreeFourth:hover, +div.CanvasXpressRowColumnFourFifth:hover, +div.CanvasXpressRowColumnFiveSixth:hover, +div.CanvasXpressRowColumnHalf:hover, +div.CanvasXpressRowColumnThird:hover, +div.CanvasXpressRowColumnFourth:hover, +div.CanvasXpressRowColumnFifth:hover, +div.CanvasXpressRowColumnSixth:hover { + border: 1px dashed rgb(238, 238, 238); +} + +div.CanvasXpressRowColumnFull { + border: 1px dashed white; + width: 100%; +} + +div.CanvasXpressRowColumnFullActive { + border: 1px dashed rgb(83, 105, 255); + width: 100%; +} + +div.CanvasXpressRowColumnTwoThird { + border: 1px dashed white; + width: 66.7%; +} + +div.CanvasXpressRowColumnTwoThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 66.7%; +} + +div.CanvasXpressRowColumnThreeFourth { + border: 1px dashed white; + width: 75%; +} + +div.CanvasXpressRowColumnThreeFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 75%; +} + +div.CanvasXpressRowColumnFourFifth { + border: 1px dashed white; + width: 80%; +} + +div.CanvasXpressRowColumnFourFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 80%; +} + +div.CanvasXpressRowColumnFiveSixth { + border: 1px dashed white; + width: 83.4%; +} + +div.CanvasXpressRowColumnFiveSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 83.4%; +} + +div.CanvasXpressRowColumnHalf { + border: 1px dashed white; + width: 50%; +} + +div.CanvasXpressRowColumnHalfActive { + border: 1px dashed rgb(83, 105, 255); + width: 50%; +} + +div.CanvasXpressRowColumnThird { + border: 1px dashed white; + width: 33.3%; +} + +div.CanvasXpressRowColumnThirdActive { + border: 1px dashed rgb(83, 105, 255); + width: 33.3%; +} + +div.CanvasXpressRowColumnFourth { + border: 1px dashed white; + width: 25%; +} + +div.CanvasXpressRowColumnFourthActive { + border: 1px dashed rgb(83, 105, 255); + width: 25%; +} + +div.CanvasXpressRowColumnFifth { + border: 1px dashed white; + width: 20%; +} + +div.CanvasXpressRowColumnFifthActive { + border: 1px dashed rgb(83, 105, 255); + width: 20%; +} + +div.CanvasXpressRowColumnSixth { + border: 1px dashed white; + width: 16.6%; +} + +div.CanvasXpressRowColumnSixthActive { + border: 1px dashed rgb(83, 105, 255); + width: 16.6%; +} + +/* + * CanvasXpress + */ + +canvas.CanvasXpress { + -moz-user-select: none; + -khtml-user-select: none; + -webkit-user-select: none; + -o-user-select: none; + user-select: none; + -ms-user-select: none; +} + +canvas.CanvasXpress:hover { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; +} + +canvas.CanvasXpressUpload { + border: 1px solid rgba(35, 82, 124, 0.2); + border-radius: 6px; + margin: -1px; + background-image: url('data:image/png;base64,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'); + background-size: contain; + background-repeat: no-repeat; +} + +canvas.CanvasXpress::selection { + background: rgba(0, 0, 0, 0); + color: rgb(0, 0, 0); +} + +div.CanvasXpressPlay { + background-color: rgba(0, 0, 0, 0.05); + background-image: url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAIAAAACACAYAAADDPmHLAAARtElEQVR42u2dB7gdRRXHT0AUMdIEARF5IBEpIh9GQIh4RSw0AwjYKIpUQQUpghUbICIWLIiU2OgoVQxFnijSFKWpFOGpFCUiLQpY0Pm92U0um5md2Tpz793/950vedvu7MzZmdNnigwfpihaWdFaisYSepGiZRN6nqJnK3qGoqnJPXMV/UfR44oeVDQnoT8pmkjoluTv/4V+wbo7a9CxvKIZijZStIGitRUt3tBvParoZkXXKfqFop8r+kvoDqiCQWSAZyrqKXqjos0VrRG4Pb9TdLGi2YrGFf0rcHsKYVAYgOn6dYrermgbRUuEbpAFjyg6V9Fpii4XvaxEjdgZ4MWKdkto+dCNKQiWhpMVnaTortCNsSFWBugpOkjRFhXbiHA3kdC9ogU86CFFTyl6MrnuWYoWUrSUaCERWlHmC5FTvX9xQSA0XqToC6KXiKgQEwPQljcr+qii6SXuR2pHKENAu0m0sPbnmtq2kqKXKVpH0fqihc5lSzznl4o+o+i8OjuuCmJhgM0UfVrRhgXuQWUbFy2AXaLotpbbvLqiN4gWRHuiVUtfXKPoY4oua7nNCyA0A7xE0bGKtvS8/gnR0+lZyb9zA7c/xdTkHXZI/l3U8z7e4QBFd4RqeCgGoIM+oeiDotU6F5jOT1T0PUV/D9RmXyytaCdFu4teNlxAbeQjOFzmyyStIQQD9BSdoGia4zqEJ6Z3OufyAO2sA6iuCLPYLFx9zSywp7QsKLbJAEjaRyra3/G7DDxC0icV/abNzmgQ64qe8WZ6vPuXFB0qLRmU2mKANUUbR9ZxXDcueln4dUvtahvriVYHe47rblT0DkW/bbpBbTAAghEGkTxd+m5FByr6YQvtiQHbKTpG0So51yDgYgA7q8mGNMkACys6SvTA2n4HU+mXFX1c0T+bfNEIsZiiT4leEhe2XMOSwIzBkvDfJhrRFAOgEzPlz8y5BifKzop+1VAbBgWvEK3dvDTnGvwLLAmP1/3jTTDAMqKl9zxr3vGiZ4ZR++ptYDbgS98755rrRZvG/1bnD9fNANjPsW7ZuLmVdW2AsaNo55FNXmLWfL1ov0YtqJMBVhXtE1/Ncv52RdtKC5LtgINIJoRhm53kTtEm6Lvr+LG6GIAvf1zsg/8z0YP/YF29NOTAG8m6P8NyHiboSQ0zQR0MwJrPANum/TMU7SoBzJwDDgxn3xG9LJjAcrCJVJQJqjIA0v6VYhf4sN8j2DSiwowAUA+/qeg9lvMIhq+RCtpBFQagceeIXdX7hqJ9ZciiaAOAMfqaon0s51kqtpeSH1kVBvi8aEeHCXz5ODa6wa8HjBN9upvlPFbFg8s+uAww755pOcea/07ppv26wYx7qphlAj60t0oJ9boMA+DYuVbMuirCIHpqJ/A1AwRD7Cwm7QAbC3kRhdTsogxAA4i5M3n10PNJzuhUvWaBini1mO0EeBFhAu8PsCgDEJxxgOF4Ke7rUBoYi4grNM3CXxTtUvdCEQboKfqJ5R7Wpc682y7o8zMMx5EHNhXPyCJfBkDfZ3oxTTs4dvbxfE6HeoGqbXIgEV7GMv2E6wG+DIBf/0OG41ijMAJ1Xr0wwIuIO91khWXMDnM9wIcBCN0mKjcbvUswx4bS+fNDg3gCtLJsUAkxhWRK54ac+zDAhWKO2y9tfOhQOxiLAw3HGbut8250MQAZO5cajuOKhLtCTP3owGOibQ5/DPD7MYKlgAIWphhD7DLWDKQ8BuAcRRBM6VoENYYI4ETg3Cv5P1PccaLj6h4N0JbYwJicYziOuvgq2015DICT51zD8XFFrw3wgki1NxqOPyA6oZRImqcCtCsmXCHmkHPG8nzTDXkMgKsx6+ZFx0ToCBG3b2PIFCSRvF/00jCqYGwYt+y4kpX8StMNNgboieamLBiAbQO9nIsBUuCkOkRGVz5gad7GcJxZezx70MYAJsmfr5/MllDpWr4MAAiQwF39ORk9GwVpaDfIgmNr1AhMDEBZljsM534k/mncTaAIA6S4R7QBixyFUYpNICz/TZljvD8xm08rV2NigM8q+rDhOCphyCxdGwMg+C3kuBdthgyc6wO2v02QlWxS/Y5Q9JH+A1kGWER0McRsQSYsga7EzqZhYwAEVdLLNnbcD6MQZEma1V8Dv0sboExOtj4BhasodzOvelmWAchj/7HhYUjXxwV+IRsDTEmIiJijkxfMw2OiZzncpgNV068gPiA61TwLlobZ6R9ZBvi2ol0yx/AoEfcfujJHHgOkwCJ2SEKumj2shfjNoynYVDOoVELeQLZczSxF707/6O88on2YGrNFGLEubR/6bcSPAVIwC6AF7ChuczdrJUEut4R+wQZwtqK3ZI5RzHI5SaKG+juHdKPZhoe8TcyBB22jCAOkwG+AfLCe49msicTfk6YeeqarEyyLpxuOM9aTPp7+zmNN3D9zIfo09fD+EfpNpBwDADQEpjzW/eUc1zL4h4sOtIi+zKsHCBnDVJ5dDgntm/Qe9nce8XzZwsvok1uEfosEZRkgBUsbKhDCkasy2a2il4VLXQ8dAGC/2TxzjEAeorvndd4Kiu4z3ByD9J+iKgOkIKyNXPytPa7FgYKg+IfQL18B71P0FcPxFyi6P+08hDxTUCfVMG8P/QYJ6mKAFKyDLHtrOq5DVUSdosTrY6E7oQQYw98bjpPcc3baeaZwb9YO15rZJupmAEAZ+veKXveXclyLhoSFdJYMntuZsczWNp4MH0877yrRSR39wKu0XeiW96EJBkhBsgW1ivcQzRR5IAYSOeKq0B1SAPRbNomX9s9IrWgPy4LbrBBRelTolvehSQZIQZgbauOmjutwrKBe4WiqqyJ5k8D8fWTmGFFUS9J5Y2IuN4L0f3HolvehDQZIQcwDgZarOq7D1Xx0QrVX8KoReHEvNBxfZUrOSXbaiom722QAgAkVuwjr/nMd1+JAw/xMMEqMbueVkjZmsSWdRxGHr2ZOzPV46bbRNgOkQF3CiLSrx2+xYQWqc4ylbhnT52SO7ccLmQo9YBf3KXXeJkIxQApi6tCnXZtaoCGcInrmeKC13nEDl/7amWPH0HnY+bNFBy4QvX1LTAjNAOlvUbGTULMVHdciZGE7wIbw7xbbaANjulXm2Jm8EBm/2TBvHCN7+zy1RcTAACmYSpGssae73M53JNddEKCd/WBM98wcu4LOM00NC4QORYCYGCAFW9SyhO7gcS2eVszKoWooMKbZZNFb6Dx8ACtkTsCxxwZqqA0xMkAKSrUx1a/ruA4P49dFWx4farmNjOkxmWOTvgAasmTmBO7TWS030IWYGQCQnUs9PyyKz3dcSxkdhMRvSXtqIxXGTsoce5jOw8GRLTXyLtHhYTEhdgZIwcfElnB44RZxXHu46K1x2gBq7KzMscfoPBMHskfv6a4ntoxBYYAU1FVgWdg85xpmgmVaag9jemr2YMcAzcGHAajzW2YH0jKwMkC3BNQLIo/YIWw/cS8BaFpHtNQu6xLQCYH1IBUCMf64vmoshNgRTmmxfVYhsFMDqwM1EDfyyx3XEV2EORkmeaTlNlrVwM4QVB5jol3BPoYgPK4YgkLtE2w1BJmqSnSm4HyQgYQez4C6TMFE4BJuN9v10IZhNQWbnEHO6lIBEAMD8FtUQidSyuUMQrZCx6fWfww5BlZnUOcO9oOvO5jBxsJHllGtW7xVhNUd3AWE5AMBmXi6XTx+i+WUgNGbW+8dN8juWixzbL8uJMwOkmVZuxGGpzqujX3vY8bSVDNpMiSM4oJ3mU6KTiuKBTEGhTJTEi6Gxc9ZmDkgcoNCu7Dw+UDuYTB9wsKpNoImcJ/roREgNywcdIkh/okhVN5knb8udIcUQG5iCOhSw9ypYVTb4Ev6vsQZ+p0HZ2qYLTmUOvS3hW59giaSQ5nu13BcR8IHHwhTaAx1EorCKzl01NLDGdCtPK6lxAol8SdCv3wFeKWHg2EvEIGQS6QOTO0qEEFRatb5n4Z+6RrgVSACUDQhu9sU0x/xbXNDv4VUKxGDKxQPnEummSPzK48Pw8aXhUrEDGORqFeLXuddRaJI3MAayt4DD4d+0RphKxI1bxOJYS0Th+ULN61PmTiWOTSgWITdOlGoTByYJTp0qB9YuBAY2o5jz8KHAZjqyNn3KRTJgDPwMaXA1wnUWgT7bKFIopDmbULtWyoWgcgkSbYJn1KxeDZf6HgOUzxTPVN+DDl7TaFUqdhBLRYNc27kuJ+s3dRNG1PWblMwuX+dxaLBMJaLR53ji7hRRgOly8WDYdowYkK0IefsgO0OAduGEYzt08oB2SRkU/jQIG0Zg8kW0y36bsy1e5pA5S1jQE8Gc9MomJTsF7SAQXDTNgHbplE9MVg2h2nbONyzrPPXBGhbLKht2zgQ28aRBGvcZDjOl47QSoDGoLlp60atG0fGuHUsuvu+yf+xZKVu2kGs4Vs3sPiZhN3SW8eCGDeP5mWI1WM9uyfA78cIon0pcT9mOFd68+gUtu3j8R4e5HF/h+bR2PbxgAAKEkWyPnTcpRuILp7cIRwQ/K4VnZ3cDxJRmaVzcxF9gylYZw81HCewAE1h1LZnjQVM/ej8qxvOEdF9mOsBvgyAZw0z6jTDueMV7RO6J0YU7G1kSuLlq8d348xVKBJP1xNdVNJ0D564M0P3xoiBWAdToA6qMGq6Vzhb0YBKU/g4IGQMdfHW0L0yIlhLtHpnSlmbDPf2fVBRBiBqCIubyTXMtAMTDNO+ezGCJJarxbwcs0wjmD/p+7AyMfVEkyJ1mriPcumbFWlAh0Iguge7zAzDOWbh9UUL5t4om1RBUsEZlvuRBaioPQxRtTEBNQ9H146Gc6z7yGFnFXqiVEurMhWWSEFY9R7S2ebrAuN0ovTF8mWAIejgsg8uCziSiOGZlvOoKNjtOyaoBsaIMjM2VRuHHVHbpWbcqpm1GCJQN6ZbzjMT7FW2cR0mP7ITxP7l4/rtSQVDXB2p1WSdXik6kdQEZIKdRZsmO/gD0/t3xbzmA4Q96hPOqfIjdRVXoGLWuKLVLOfRDlgqOhXRD0srOk/M0j64U/SXf2/VH6qzugalZi4ROxNgJyCcrDMW5QMjD7EW0yznGXxcvBN1/Fjd9XWYCfA925YDdFXq6XZmYzOY7pGbbEWpmPYZ/MpffoomCiwhExBCPj3nGhxImCtHLWLXBoRp4ivyqrMi8BGXUWnNz6KpEmu8EKVUtsm5hqoVO0kXT4A/n75aPecaVD0qlNbudm+yyCIqDD7pA3N+B/WQ/DUKN4zabICLncJUbE+7sOUabCjMDMRiNKJKt1FmFbPxyZJfbJEYQ6yKP2ihPTGAAE6sd2M51yAvof8XNu8WQVt1dnEgnSbuBNNx0TPGDS21q20w3TPwPcd1ePXY4qWQY6cM2qy0jSuZ0LL9Hb/LtIcOTKXtUGlodYN0LbaRmenx7iyJhHK14lENUWu/J9q8Oc1xHZ1BHjtfTMis5CogS5eljboLrr7GTkI9//E2Gxhqtw0EIPL0UQVdFbsAue7ox2T/hK5U4gKVOagsvrssmJ9vAiZyIq2Y8VqvNxx6vx1mAUKYfNPO6aCLRAtGxLzHUriRzaTJpt4heZdFPe8LvY1McAZIQRQRKpFrM4Z+oDaOi86FxwTddpEn9HYqq1GDryfumkT9IJ4P1feyAvc0glgYIAVCEnX6ppe4FwsZuYx0LksGiaR17XdAWRU0GBJUYVLK0ZTZ8JEsXRj9/BL3NoLYGCBFT7Q6uGXFNrJEYGOYEG0/xxvJdq3IERhWUhc1cgjGGNZvgi7xxuHXGBOdh7hYgd/MAmGWZQuDznjrPelArAyQgs7HeYRBZPmKz2obFGTCAIbwelfFZzWG2BkgBdXL2MSBqqW4lJeo9rjGQBFGXLlU5ySJJvoydIPCAP3AoLSJ6CJICGCucu9NA2sdgij1FYmMGqiQ+EFkgCwodb+xaMGMuHgEtcUrPdEOtllBwCQ5BoGTXTfuD90BVTAMDGB6p5VF+x+IUhoTXTt42YQQ8lDZ2C0kdVDheKF4IqolQuKchCiaOSFakKScPjtvDVWU8/8BFWavcIiHLzgAAAAASUVORK5CYII='); + background-position-x: 50%; + background-position-y: center; + background-size: 25%; + background-repeat: no-repeat; + position: absolute; +} + +div.CanvasXpressPlay:hover { + background-color: rgba(0, 0, 0, 0); +} + +div.CanvasXpressContainer { + box-sizing: border-box; + position: relative; + float: left; +} + +div.CanvasXpressWrapper { + box-sizing: border-box; + position: relative; + float: left; + line-height: 100%; +} + +/* + * full-screen-warning-container + */ + +#full-screen-warning-container { + background-color: transparent !important; + opacity: 0.4 !important; +} + +#full-screen-warning-container[fade-warning-out] { + transition-property: opacity !important; + transition-duration: 1ms !important; + opacity: 0.0 !important; +} + +#full-screen-warning-message { + padding: 15px !important; +} + +.full-screen-description { + font-size: 100% !important; +} + +#full-screen-domain-text { + font-size: 100% !important; + font-weight: bold !important; +} + +.full-screen-approval-button, +#full-screen-remember-decision { + font-size: 100% !important; +} + +@media (min-width: 300px) { + div.cX-bin { + transform: scale(0.5); + } +} + +@media (min-width: 450px) { + div.cX-bin { + transform: scale(0.75); + } +} + +@media (min-width: 600px) { + div.cX-bin { + transform: scale(1); + } +} + + +/* Genie Effect */ + +.genie { + position: relative; + background-repeat: no-repeat; + background-size: cover; +} + +.genie .genie-step { + background-repeat: no-repeat; + background-image: inherit; + position: absolute; +} + +.genie.genie-expand .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-collapse .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +.genie.genie-collapse.change-pace .genie-step { + -moz-transition: background-position 800ms ease-in-out; + -webkit-transition: background-position 800ms ease-in-out; + -o-transition: background-position 800ms ease-in-out; + -ms-transition: background-position 800ms ease-in-out; + transition: background-position 800ms ease-in-out; +} + +.genie.genie-expand.change-pace .genie-step { + -moz-transition: all 300ms ease-in-out; + -webkit-transition: all 300ms ease-in-out; + -o-transition: all 300ms ease-in-out; + -ms-transition: all 300ms ease-in-out; + transition: all 300ms ease-in-out; +} + +/* Hide Efect */ + +.appear { + transition: all 1s linear; + opacity: 1; +} + +.dissapear { + display: none; +} + +.dissapearHidden { + transition: all 1s linear; + opacity: 0; +} + +/* Magic Effects */ + + +/* +Magic - Ver 1.3.0 - https://minimamente.com +Licensed under the MIT license +Copyright (c) 2018 Christian Pucci +*/ + +.magictime { + -webkit-animation-duration: 1s; + animation-duration: 1s; + -webkit-animation-fill-mode: both; + animation-fill-mode: both; +} + +.showIn { + -webkit-animation-name: showIn; + animation-name: showIn; +} + +@-webkit-keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +@keyframes showIn { + 0% { + opacity: 0; + } + + 100% { + opacity: 1; + } +} + +.showOut { + -webkit-animation-name: showOut; + animation-name: showOut; +} + +@-webkit-keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +@keyframes showOut { + 0% { + opacity: 1; + } + + 100% { + opacity: 0; + } +} + +.puffIn { + -webkit-animation-name: puffIn; + animation-name: puffIn; +} + +@-webkit-keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes puffIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.puffOut { + -webkit-animation-name: puffOut; + animation-name: puffOut; +} + +@-webkit-keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +@keyframes puffOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(2px); + filter: blur(2px); + } +} + +.vanishIn { + -webkit-animation-name: vanishIn; + animation-name: vanishIn; +} + +@-webkit-keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +@keyframes vanishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(90px); + filter: blur(90px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } +} + +.vanishOut { + -webkit-animation-name: vanishOut; + animation-name: vanishOut; +} + +@-webkit-keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes vanishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(2, 2); + transform: scale(2, 2); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.boingInUp { + -webkit-animation-name: boingInUp; + animation-name: boingInUp; +} + +@-webkit-keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes boingInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(-90deg); + transform: perspective(800px) rotateX(-90deg); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(50deg); + transform: perspective(800px) rotateX(50deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.boingOutDown { + -webkit-animation-name: boingOutDown; + animation-name: boingOutDown; +} + +@-webkit-keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +@keyframes boingOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(10deg); + transform: perspective(800px) rotateX(0deg) rotateY(10deg); + } + + 30% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(0deg) rotateY(0deg); + transform: perspective(800px) rotateX(0deg) rotateY(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: perspective(800px) rotateX(10deg) rotateY(10deg); + transform: perspective(800px) rotateX(10deg) rotateY(10deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: perspective(800px) rotateX(90deg) rotateY(0deg); + transform: perspective(800px) rotateX(90deg) rotateY(0deg); + } +} + +.foolishIn { + -webkit-animation-name: foolishIn; + animation-name: foolishIn; +} + +@-webkit-keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +@keyframes foolishIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(360deg); + transform: scale(0, 0) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } +} + +.foolishOut { + -webkit-animation-name: foolishOut; + animation-name: foolishOut; +} + +@-webkit-keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +@keyframes foolishOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotate(360deg); + transform: scale(1, 1) rotate(360deg); + } + + 20% { + opacity: 1; + -webkit-transform-origin: 0% 0%; + transform-origin: 0% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 40% { + opacity: 1; + -webkit-transform-origin: 100% 0%; + transform-origin: 100% 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 60% { + opacity: 1; + -webkit-transform-origin: 0%; + transform-origin: 0%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 0% 100%; + transform-origin: 0% 100%; + -webkit-transform: scale(0.5, 0.5) rotate(0deg); + transform: scale(0.5, 0.5) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotate(0deg); + transform: scale(0, 0) rotate(0deg); + } +} + +.holeIn { + -webkit-animation-name: holeIn; + animation-name: holeIn; +} + +@-webkit-keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +@keyframes holeIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(360deg); + transform: scale(0, 0) rotateY(360deg); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } +} + +.holeOut { + -webkit-animation-name: holeOut; + animation-name: holeOut; +} + +@-webkit-keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +@keyframes holeOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1) rotateY(0deg); + transform: scale(1, 1) rotateY(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0) rotateY(180deg); + transform: scale(0, 0) rotateY(180deg); + } +} + +.swashIn { + -webkit-animation-name: swashIn; + animation-name: swashIn; +} + +@-webkit-keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +@keyframes swashIn { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } + + 90% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } +} + +.swashOut { + -webkit-animation-name: swashOut; + animation-name: swashOut; +} + +@-webkit-keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +@keyframes swashOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(1, 1); + transform: scale(1, 1); + } + + 80% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0.9, 0.9); + transform: scale(0.9, 0.9); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: scale(0, 0); + transform: scale(0, 0); + } +} + +.bombLeftOut { + -webkit-animation-name: bombLeftOut; + animation-name: bombLeftOut; +} + +@-webkit-keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: -100% 50%; + transform-origin: -100% 50%; + -webkit-transform: rotate(-160deg); + transform: rotate(-160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.bombRightOut { + -webkit-animation-name: bombRightOut; + animation-name: bombRightOut; +} + +@-webkit-keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +@keyframes bombRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 50%; + transform-origin: 50% 50%; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 50% { + opacity: 1; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(0px); + filter: blur(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 50%; + transform-origin: 200% 50%; + -webkit-transform: rotate(160deg); + transform: rotate(160deg); + -webkit-filter: blur(20px); + filter: blur(20px); + } +} + +.magic { + -webkit-animation-name: magic; + animation-name: magic; +} + +@-webkit-keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +@keyframes magic { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 200%; + transform-origin: 100% 200%; + -webkit-transform: scale(1, 1) rotate(0deg); + transform: scale(1, 1) rotate(0deg); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 200% 500%; + transform-origin: 200% 500%; + -webkit-transform: scale(0, 0) rotate(270deg); + transform: scale(0, 0) rotate(270deg); + } +} + +.swap { + -webkit-animation-name: swap; + animation-name: swap; +} + +@-webkit-keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +@keyframes swap { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) translate(-700px, 0px); + transform: scale(0, 0) translate(-700px, 0px); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) translate(0px, 0px); + transform: scale(1, 1) translate(0px, 0px); + } +} + +.twisterInDown { + -webkit-animation-name: twisterInDown; + animation-name: twisterInDown; +} + +@-webkit-keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +@keyframes twisterInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 30% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(-100%); + transform: scale(0, 0) rotate(360deg) translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 100%; + transform-origin: 100% 100%; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0%); + transform: scale(1, 1) rotate(0deg) translateY(0%); + } +} + +.twisterInUp { + -webkit-animation-name: twisterInUp; + animation-name: twisterInUp; +} + +@-webkit-keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +@keyframes twisterInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 30% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: scale(0, 0) rotate(360deg) translateY(100%); + transform: scale(0, 0) rotate(360deg) translateY(100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: scale(1, 1) rotate(0deg) translateY(0); + transform: scale(1, 1) rotate(0deg) translateY(0); + } +} + +.spaceInDown { + -webkit-animation-name: spaceInDown; + animation-name: spaceInDown; +} + +@-webkit-keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInDown { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInLeft { + -webkit-animation-name: spaceInLeft; + animation-name: spaceInLeft; +} + +@-webkit-keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInLeft { + 0% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInRight { + -webkit-animation-name: spaceInRight; + animation-name: spaceInRight; +} + +@-webkit-keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInRight { + 0% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceInUp { + -webkit-animation-name: spaceInUp; + animation-name: spaceInUp; +} + +@-webkit-keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +@keyframes spaceInUp { + 0% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } +} + +.spaceOutDown { + -webkit-animation-name: spaceOutDown; + animation-name: spaceOutDown; +} + +@-webkit-keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +@keyframes spaceOutDown { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: scale(.2) translate(0%, 200%); + transform: scale(.2) translate(0%, 200%); + } +} + +.spaceOutLeft { + -webkit-animation-name: spaceOutLeft; + animation-name: spaceOutLeft; +} + +@-webkit-keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +@keyframes spaceOutLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0% 50%; + transform-origin: 0% 50%; + -webkit-transform: scale(.2) translate(-200%, 0%); + transform: scale(.2) translate(-200%, 0%); + } +} + +.spaceOutRight { + -webkit-animation-name: spaceOutRight; + animation-name: spaceOutRight; +} + +@-webkit-keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +@keyframes spaceOutRight { + 0% { + opacity: 1; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 100% 50%; + transform-origin: 100% 50%; + -webkit-transform: scale(.2) translate(200%, 0%); + transform: scale(.2) translate(200%, 0%); + } +} + +.spaceOutUp { + -webkit-animation-name: spaceOutUp; + animation-name: spaceOutUp; +} + +@-webkit-keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +@keyframes spaceOutUp { + 0% { + opacity: 1; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(1) translate(0%, 0%); + transform: scale(1) translate(0%, 0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0%; + transform-origin: 50% 0%; + -webkit-transform: scale(.2) translate(0%, -200%); + transform: scale(.2) translate(0%, -200%); + } +} + +.perspectiveDown { + -webkit-animation-name: perspectiveDown; + animation-name: perspectiveDown; +} + +@-webkit-keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +@keyframes perspectiveDown { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } +} + +.perspectiveDownReturn { + -webkit-animation-name: perspectiveDownReturn; + animation-name: perspectiveDownReturn; +} + +@-webkit-keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveDownReturn { + 0% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(-180deg); + transform: perspective(800px) rotateX(-180deg); + } + + 100% { + -webkit-transform-origin: 0 100%; + transform-origin: 0 100%; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.perspectiveLeft { + -webkit-animation-name: perspectiveLeft; + animation-name: perspectiveLeft; +} + +@-webkit-keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +@keyframes perspectiveLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } +} + +.perspectiveLeftReturn { + -webkit-animation-name: perspectiveLeftReturn; + animation-name: perspectiveLeftReturn; +} + +@-webkit-keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(-180deg); + transform: perspective(800px) rotateY(-180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveRight { + -webkit-animation-name: perspectiveRight; + animation-name: perspectiveRight; +} + +@-webkit-keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +@keyframes perspectiveRight { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } +} + +.perspectiveRightReturn { + -webkit-animation-name: perspectiveRightReturn; + animation-name: perspectiveRightReturn; +} + +@-webkit-keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +@keyframes perspectiveRightReturn { + 0% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(180deg); + transform: perspective(800px) rotateY(180deg); + } + + 100% { + -webkit-transform-origin: 100% 0; + transform-origin: 100% 0; + -webkit-transform: perspective(800px) rotateY(0deg); + transform: perspective(800px) rotateY(0deg); + } +} + +.perspectiveUp { + -webkit-animation-name: perspectiveUp; + animation-name: perspectiveUp; +} + +@-webkit-keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +@keyframes perspectiveUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } +} + +.perspectiveUpReturn { + -webkit-animation-name: perspectiveUpReturn; + animation-name: perspectiveUpReturn; +} + +@-webkit-keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +@keyframes perspectiveUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(180deg); + transform: perspective(800px) rotateX(180deg); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg); + transform: perspective(800px) rotateX(0deg); + } +} + +.rotateDown { + -webkit-animation-name: rotateDown; + animation-name: rotateDown; +} + +@-webkit-keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +@keyframes rotateDown { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 100%; + transform-origin: 50% 100%; + -webkit-transform: perspective(800px) rotateX(-180deg) translateZ(300px); + transform: perspective(800px) rotateX(-180deg) translateZ(300px); + } +} + +.rotateLeft { + -webkit-animation-name: rotateLeft; + animation-name: rotateLeft; +} + +@-webkit-keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +@keyframes rotateLeft { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translateZ(0px); + transform: perspective(800px) rotateY(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(-180deg) translateZ(300px); + transform: perspective(800px) rotateY(-180deg) translateZ(300px); + } +} + +.rotateRight { + -webkit-animation-name: rotateRight; + animation-name: rotateRight; +} + +@-webkit-keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +@keyframes rotateRight { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateY(0deg) translate3d(0px); + transform: perspective(800px) rotateY(0deg) translate3d(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateY(180deg) translateZ(150px); + transform: perspective(800px) rotateY(180deg) translateZ(150px); + } +} + +.rotateUp { + -webkit-animation-name: rotateUp; + animation-name: rotateUp; +} + +@-webkit-keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +@keyframes rotateUp { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: perspective(800px) rotateX(0deg) translateZ(0px); + transform: perspective(800px) rotateX(0deg) translateZ(0px); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 50% 0; + transform-origin: 50% 0; + -webkit-transform: perspective(800px) rotateX(180deg) translateZ(100px); + transform: perspective(800px) rotateX(180deg) translateZ(100px); + } +} + +.slideDown { + -webkit-animation-name: slideDown; + animation-name: slideDown; +} + +@-webkit-keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown2 { + -webkit-animation-name: slideDown2; + animation-name: slideDown2; +} + +@-webkit-keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown2 { + 0% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDown3 { + -webkit-animation-name: slideDown3; + animation-name: slideDown3; +} + +@-webkit-keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +@keyframes slideDown3 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } +} + +.slideDownReturn { + -webkit-animation-name: slideDownReturn; + animation-name: slideDownReturn; +} + +@-webkit-keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideDownReturn2 { + -webkit-animation-name: slideDownReturn2; + animation-name: slideDownReturn2; +} + +@-webkit-keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideDownReturn2 { + 0% { + height: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(100%); + transform: translateY(100%); + } + + 100% { + height: 215px; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideLeft { + -webkit-animation-name: slideLeft; + animation-name: slideLeft; +} + +@-webkit-keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +@keyframes slideLeft { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } +} + +.slideLeftReturn { + -webkit-animation-name: slideLeftReturn; + animation-name: slideLeftReturn; +} + +@-webkit-keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideLeftReturn2 { + -webkit-animation-name: slideLeftReturn2; + animation-name: slideLeftReturn2; +} + +@-webkit-keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideLeftReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(-100%); + transform: translateX(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideRight { + -webkit-animation-name: slideRight; + animation-name: slideRight; +} + +@-webkit-keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +@keyframes slideRight { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } +} + +.slideRightReturn { + -webkit-animation-name: slideRightReturn; + animation-name: slideRightReturn; +} + +@-webkit-keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +@keyframes slideRightReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(100%); + transform: translateX(100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateX(0%); + transform: translateX(0%); + } +} + +.slideUp { + -webkit-animation-name: slideUp; + animation-name: slideUp; +} + +@-webkit-keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUp2 { + -webkit-animation-name: slideUp2; + animation-name: slideUp2; +} + +@-webkit-keyframes slideUp2 { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +@keyframes slideUp2 { + 0% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } + + 100% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } +} + +.slideUpReturn { + -webkit-animation-name: slideUpReturn; + animation-name: slideUpReturn; +} + +@-webkit-keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn { + 0% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.slideUpReturn2 { + -webkit-animation-name: slideUpReturn2; + animation-name: slideUpReturn2; +} + +@-webkit-keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +@keyframes slideUpReturn2 { + 0% { + opacity: 0; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(-100%); + transform: translateY(-100%); + } + + 100% { + opacity: 1; + -webkit-transform-origin: 0 0; + transform-origin: 0 0; + -webkit-transform: translateY(0%); + transform: translateY(0%); + } +} + +.openDownLeft { + -webkit-animation-name: openDownLeft; + animation-name: openDownLeft; +} + +@-webkit-keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeft { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownLeftReturn { + -webkit-animation-name: openDownLeftReturn; + animation-name: openDownLeftReturn; +} + +@-webkit-keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownLeftReturn { + 0% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownRight { + -webkit-animation-name: openDownRight; + animation-name: openDownRight; +} + +@-webkit-keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRight { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightReturn { + -webkit-animation-name: openDownRightReturn; + animation-name: openDownRightReturn; +} + +@-webkit-keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openDownRightReturn { + 0% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpLeft { + -webkit-animation-name: openUpLeft; + animation-name: openUpLeft; +} + +@-webkit-keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeft { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftReturn { + -webkit-animation-name: openUpLeftReturn; + animation-name: openUpLeftReturn; +} + +@-webkit-keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpLeftReturn { + 0% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openUpRight { + -webkit-animation-name: openUpRight; + animation-name: openUpRight; +} + +@-webkit-keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRight { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightReturn { + -webkit-animation-name: openUpRightReturn; + animation-name: openUpRightReturn; +} + +@-webkit-keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +@keyframes openUpRightReturn { + 0% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } + + 100% { + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } +} + +.openDownLeftOut { + -webkit-animation-name: openDownLeftOut; + animation-name: openDownLeftOut; +} + +@-webkit-keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom left; + transform-origin: bottom left; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openDownRightOut { + -webkit-animation-name: openDownRightOut; + animation-name: openDownRightOut; +} + +@-webkit-keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openDownRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: bottom right; + transform-origin: bottom right; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpLeftOut { + -webkit-animation-name: openUpLeftOut; + animation-name: openUpLeftOut; +} + +@-webkit-keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpLeftOut { + 0% { + opacity: 1; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top left; + transform-origin: top left; + -webkit-transform: rotate(110deg); + transform: rotate(110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.openUpRightOut { + -webkit-animation-name: openUpRightOut; + animation-name: openUpRightOut; +} + +@-webkit-keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +@keyframes openUpRightOut { + 0% { + opacity: 1; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(0deg); + transform: rotate(0deg); + -webkit-animation-timing-function: ease-out; + animation-timing-function: ease-out; + } + + 100% { + opacity: 0; + -webkit-transform-origin: top right; + transform-origin: top right; + -webkit-transform: rotate(-110deg); + transform: rotate(-110deg); + -webkit-animation-timing-function: ease-in-out; + animation-timing-function: ease-in-out; + } +} + +.tinDownIn { + -webkit-animation-name: tinDownIn; + animation-name: tinDownIn; +} + +@-webkit-keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinDownIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinDownOut { + -webkit-animation-name: tinDownOut; + animation-name: tinDownOut; +} + +@-webkit-keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +@keyframes tinDownOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(900%); + transform: scale(1, 1) translateY(900%); + } +} + +.tinLeftIn { + -webkit-animation-name: tinLeftIn; + animation-name: tinLeftIn; +} + +@-webkit-keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinLeftIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinLeftOut { + -webkit-animation-name: tinLeftOut; + animation-name: tinLeftOut; +} + +@-webkit-keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +@keyframes tinLeftOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(-900%); + transform: scale(1, 1) translateX(-900%); + } +} + +.tinRightIn { + -webkit-animation-name: tinRightIn; + animation-name: tinRightIn; +} + +@-webkit-keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +@keyframes tinRightIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } +} + +.tinRightOut { + -webkit-animation-name: tinRightOut; + animation-name: tinRightOut; +} + +@-webkit-keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +@keyframes tinRightOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateX(0); + transform: scale(1, 1) translateX(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateX(0); + transform: scale(1.1, 1.1) translateX(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateX(900%); + transform: scale(1, 1) translateX(900%); + } +} + +.tinUpIn { + -webkit-animation-name: tinUpIn; + animation-name: tinUpIn; +} + +@-webkit-keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +@keyframes tinUpIn { + 0% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } + + 50%, + 70%, + 90% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 60%, + 80%, + 100% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } +} + +.tinUpOut { + -webkit-animation-name: tinUpOut; + animation-name: tinUpOut; +} + +@-webkit-keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +@keyframes tinUpOut { + + 0%, + 20%, + 40%, + 50% { + opacity: 1; + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); + } + + 10%, + 30% { + opacity: 1; + -webkit-transform: scale(1.1, 1.1) translateY(0); + transform: scale(1.1, 1.1) translateY(0); + } + + 100% { + opacity: 0; + -webkit-transform: scale(1, 1) translateY(-900%); + transform: scale(1, 1) translateY(-900%); + } +} + +.blink { + -webkit-animation-name: blink; + animation-name: blink; +} + +@-webkit-keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} + +@keyframes blink { + 0% { + opacity: 0; + background-color: rgba(51, 122, 183, 1); + } + + 25% { + opacity: 0.25; + background-color: rgba(51, 122, 183, 0.75); + } + + 50% { + opacity: 0.5; + background-color: rgba(51, 122, 183, 0.5); + } + + 75% { + opacity: 0.75; + background-color: rgba(51, 122, 183, 0.25); + } + + 100% { + opacity: 1; + background-color: rgba(51, 122, 183, 0); + } +} \ No newline at end of file diff --git a/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.min.js b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.min.js new file mode 100644 index 00000000..bef6f562 --- /dev/null +++ b/docs/articles/drugbank_nside_files/canvasXpress-58.7/canvasXpress.min.js @@ -0,0 +1,303 @@ +/** + * + * CanvasXpress 58.7 - JavaScript Canvas Library + * + * Copyright (c) 2009-2025 - license@canvasxpress.org + * + * Redistributions of the source code must retain this copyright + * notice and the following disclaimer. + * + * CanvasXpress is released as open source for personal and + * educational use with dual licensing for commercial purposes. + * + * This program is distributed in the hope that it will be useful, + * but WITHOUT ANY WARRANTY; without even the implied warranty of + * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. + * + * Please see a copy of the CanvasXpress License at + * https://www.canvasxpress.org/docs/license.html. + * + * Dual licensing: + * Commercial use may be granted to the extent that this source + * code does NOT become part of any other Open Source or + * Commercially licensed development library or toolkit without + * explicit permission from CanvasXpress. + * + */ +/** + * + * sprintf() for JavaScript v.0.4 + * + * Copyright (c) 2007 Alexandru Marasteanu + * Thanks to David Baird (unit test and patch). + * + * This program is free software; you can redistribute it and/or modify it under + * the terms of the GNU General Public License as published by the Free Software + * Foundation; either version 2 of the License, or (at your option) any later + * version. + * + * This program is distributed in the hope that it will be useful, but WITHOUT + * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS + * FOR A PARTICULAR PURPOSE. See the GNU General Public License for more + * details. + * + * You should have received a copy of the GNU General Public License along with + * this program; if not, write to the Free Software Foundation, Inc., 59 Temple + * Place, Suite 330, Boston, MA 02111-1307 USA + * + *** + * + * Date Format 1.2.3 + * (c) 2007-2009 Steven Levithan + * MIT license + * + * Includes enhancements by Scott Trenda + * and Kris Kowal + * + * Accepts a date, a mask, or a date and a mask. + * Returns a formatted version of the given date. + * The date defaults to the current date/time. + * The mask defaults to dateFormat.masks.default. + * + **** + * + * jLouvain.js + * Author: Corneliu S. (github.com/upphiminn) + * This is a javascript implementation of the Louvain + * community detection algorithm (http://arxiv.org/abs/0803.0476) + * Based on https://bitbucket.org/taynaud/python-louvain/overview + * + **** + * + * science.js + * Copyright (c) 2011, Jason Davies + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * The name Jason Davies may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND + * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED + * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE + * DISCLAIMED. IN NO EVENT SHALL JASON DAVIES BE LIABLE FOR ANY DIRECT, INDIRECT, + * INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT + * LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR + * PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF + * LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE + * OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF + * ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * Apache-Style Software License for ColorBrewer software and ColorBrewer Color + * Schemes + * + * Copyright (c) 2002 Cynthia Brewer, Mark Harrower, and The Pennsylvania State + * University. + * + * Licensed under the Apache License, Version 2.0 (the "License"); you may not + * use this file except in compliance with the License. You may obtain a copy of + * the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, WITHOUT + * WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the + * License for the specific language governing permissions and limitations under + * the License. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * 1. Redistributions as source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * 2. The end-user documentation included with the redistribution, if any, must + * include the following acknowledgment: "This product includes color + * specifications and designs developed by Cynthia Brewer + * (http://colorbrewer.org/)." Alternately, this acknowledgment may appear in the + * software itself, if and wherever such third-party acknowledgments normally + * appear. + * + * 4. The name "ColorBrewer" must not be used to endorse or promote products + * derived from this software without prior written permission. For written + * permission, please contact Cynthia Brewer at cbrewer@psu.edu. + * + * 5. Products derived from this software may not be called "ColorBrewer", nor + * may "ColorBrewer" appear in their name, without prior written permission of + * Cynthia Brewer. + * + **** + * + * FileSaver.js + * Copyright © 2015 [Eli Grey][1]. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * canvas-toBlob.js + * Copyright © 2011 Eli Grey and Devin Samarin. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * Blob.js + * Copyright © 2014 Eli Grey. + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is furnished + * to do so, subject to the following conditions: + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, + * INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A + * PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT + * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION + * OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE + * OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + * + **** + * + * jstat.js + * Copyright (c) 2013 jStat + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * numeric.js + * Numeric Javascript + * Copyright (C) 2011 by Sébastien Loisel + * + * Permission is hereby granted, free of charge, to any person obtaining a copy + * of this software and associated documentation files (the "Software"), to deal + * in the Software without restriction, including without limitation the rights + * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + * copies of the Software, and to permit persons to whom the Software is + * furnished to do so, subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in + * all copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + * THE SOFTWARE. + * + **** + * + * Sankey.js + * Copyright (c) 2012, Michael Bostock + * All rights reserved. + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * * Redistributions of source code must retain the above copyright notice, this + * list of conditions and the following disclaimer. + * + * * Redistributions in binary form must reproduce the above copyright notice, + * this list of conditions and the following disclaimer in the documentation + * and/or other materials provided with the distribution. + * + * * The name Michael Bostock may not be used to endorse or promote products + * derived from this software without specific prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" + * AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE + * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE + * ARE DISCLAIMED. IN NO EVENT SHALL MICHAEL BOSTOCK BE LIABLE FOR ANY DIRECT, + * INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES + * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; + * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND + * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT + * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS + * SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + * + **** + * + * canvas2svg + * The MIT License (MIT) + * + * Copyright (c) 2014 Gliffy Inc. + * + * Permission is hereby granted, free of charge, to any person obtaining a copy of + * this software and associated documentation files (the "Software"), to deal in + * the Software without restriction, including without limitation the rights to + * use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of + * the Software, and to permit persons to whom the Software is furnished to do so, + * subject to the following conditions: + * + * The above copyright notice and this permission notice shall be included in all + * copies or substantial portions of the Software. + * + * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS + * FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR + * COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER + * IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + * CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + */ +(function(b,a){if(typeof exports==="object"){a(exports)}else{(a((b.CanvasXpress=b.CanvasXpress||{})))}}(this,(function(){CanvasXpress=typeof CanvasXpress!="undefined"&&CanvasXpress.ready?CanvasXpress:function(n,h,e,s,d,p,r,l){var k=this;var q=function(){k.init(n,h,e,s,d,p,r,l)};var c=function(i){if(i){k.init(i);if(r){r(i)}}else{k.init(n,h,e,s,d,p,r,l)}};var j=document.styleSheets;var b=false;for(var g=0;g-1){b=true;break}}if(e&&typeof e=="string"){e={prompt:e,llmBehaviour:"update",view:"table"}}else{if(n&&n.config&&n.config.prompt&&n.config.isR){n.config.llmBehaviour="update";n.config.view="table"}}if(!b){var 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provided")}else{if(typeof(f)=="object"&&f.renderTo){d=f.tracks?{tracks:f.tracks}:f.nodes?{nodes:f.nodes}:f.venn?{venn:f.venn}:f.data?f.data:false;b=f.config||false;if(f.version){b.createVersion=f.version}if(f.factory){b.createFactory=f.factory}c=f.events||false;e=f.info?f.info.replace(/'/g,"'").replace(/"/g,"'"):false;h=f.afterRender||false;g=f.callback||false;a=f.noValidate?f.noValidate:b&&b.noValidate?b.noValidate:false;f=f.renderTo;CanvasXpress.inject(f)}else{if(typeof f==="string"||f instanceof String){CanvasXpress.inject(f)}}}return{target:f,data:d,config:b,events:c,info:e,afterRender:h,callback:g,noValidate:a}};CanvasXpress.inject=function(c){if(typeof c==="string"||c instanceof String){var b=document.getElementById(c);if(b!==null){if(b.tagName.toLowerCase()=="canvas"){if(!b.width){b.width=500}if(!b.height){b.height=500}}else{if(b.tagName.toLowerCase()=="div"){b.id=c+"-div";var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;b.appendChild(a)}}}else{var a=document.createElement("canvas");a.id=c;a.width=500;a.height=500;document.body.appendChild(a)}}};CanvasXpress.loadFonts=function(d,c){if(d&&d.length&&c){var b=false;for(var a=0;a: "+k.parameters[l]+"

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z=document.createElement("div");z.style.width=w+"px";z.style.height="100px";z.style.clear="both";z.style.position="relative";z.style.margin="auto";var n=document.createElement("span");n.innerHTML=a.datetime;n.style.cssFloat="right";var d=document.createElement("span");d.innerHTML=a.prompt;d.style.cssFloat="left";d.style.fontWeight="bold";var y=document.createElement("span");y.innerHTML=a.client;y.style.cssFloat="left";var x=document.createElement("br");var v=document.createElement("br");var h=document.createElement("br");z.appendChild(x);z.appendChild(y);z.appendChild(n);z.appendChild(v);z.appendChild(d);z.appendChild(h);return z};var e=function(h,d){var n=document.createElement("div");if(d){n.className=d}n.appendChild(h);return n};var j=function(w,h){var x=CanvasXpress.parametersLLM;h.CZ();var n=h.meta.config.user;var d={graphOrientation:true,graphType:true,isR:true,prompt:true};for(var v=0;v=0){that.rY([vi,x,y]);draw=true}if(si>=0){that.rY([that.varIndices[0],si]);draw=true}}if(draw){that.z4()}}};var isPWC=function(){for(var i=0;i0?ar.shift():[];var cn=ar.length>0?ar.shift():{};var tm=ar.length>0?ar.shift():t;var rp=ar.length>0?ar.shift():false;if(this.view=="table"&&fn=="setDimensions"){continue}if(fn=="setDimensions"){if(this.width==pr[0]&&this.height==pr[1]){continue}}if(fn=="clickView"){cv=true;continue}if(fn=="updateDataFilter"||fn=="resetDataFilter"){this.skipRender=true}var dr=arr[i+1]&&arr[i+1][0]&&arr[i+1][0].match(/drag/i)?true:false;this.skipRender=fn=="createDOE"||fn=="createHistogram"||fn=="modifyColorScheme"||fn.match(/segregate/)||dr?false:!this.showTransition&&i0&&!CanvasXpress.readyFonts){CanvasXpress.readyFonts=true;return}t.fo("canvasXpress data ready - 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t=this;t.wu(o);t.GW("init");t.T4();t.gh(o);t.uU();t.Ki();t.Vd();t.YX();t.uo(o.config);t.y8();t.Pw();t.CI();t.jY(o.data);t.GW("initData");t.sb();t.EP();t.fR();t.zA();t.sw(o.data,o.config,o.events,o.info,o.afterRender);t.wE();t.Ki();t.c9(o.callback)};this.uY(o)};CanvasXpress.prototype.initStart=function(){this.initIO();this.initCrypt();this.initDOM();this.initViewport();this.initConfig()};CanvasXpress.prototype.initDataset=function(){this.yi=function(){delete (this.meta.data);this.cN(false,false,false,true)};this.af=function(c){if(c){this.meta.data={tracks:[]}}for(var H=0;HF){F=g;K=x[B].length;u=x[B]}}var e=[];for(var B=0;BI){I=h;O=B[H].length;A=B[H]}}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A;c.colors=[];var p=0;for(var H=0;HI){I=h;O=c.levels[H].toString().length;A=c.levels[H]}c.maxLevLen=I;c.maxLevChr=O;c.maxLevStr=A}c.shapes=this.shapes;c.sizes=this.sizes;c.patterns=this.patterns}P[E][G]=c}}}}if(this.decorations.length&&this.decorationsType=="heatmap"){var u=[];P.decorations={};P.decorations.unique=false;P.decorations.type="Numeric";P.decorations.n=0;for(var H=0;HI){I=h;O=P.decorations.levels[H].toString().length;A=P.decorations.levels[H]}P.decorations.maxLevLen=I;P.decorations.maxLevChr=O;P.decorations.maxLevStr=A}}}};this.FV=function(O,af,ac,P,ah){var J=this;var G=this.meta.config.user;var A=this.meta.data;var l=this.data;var C=CanvasXpress.colorSchemes;var p=["x","z","w"];var Y=this.font;var D=function(s,a,r,ai,al,ak){var t={};if(J.legendOrder&&J.legendOrder[s]){for(var aj=0;ajr[r.length-1]){t--;while(!C[J[ai+"Key"][U]][t]){t--}}else{if(td.length&&d.length==1&&J.graphType=="Map"){var t=S.length;var r=J.p4(C[J.colorScheme]);r.sort(function(aj,j){return aj-j});if(t>r[r.length-1]){t--;while(!C[J.colorScheme][t]){t--}}else{if(t10?d.colorBrew.vals:aj;d.order={};for(var s=0;sag){ag=t;c=d.levels[s].toString().length;aa=d.levels[s]}d.maxLevLen=ag;d.maxLevChr=c;d.maxLevStr=aa}}else{d[a+"s"]=a=="connect"?J.colors:J[a+"s"]}};if(!O||O=="w"||O=="x"||O=="z"){if(O&&ac){if(!af){delete (A[O])}else{if(A[O][af]){delete (A[O][af])}}}for(var X=0;Xag){ag=E;c=S[V].length;aa=S[V]}}I.maxLevLen=ag;I.maxLevChr=c;I.maxLevStr=aa;Z("color",this.colors,I);Z("shape",this.shapes,I);Z("size",this.Pk(S.length),I);Z("pattern",this.patterns,I);Z("linePattern",this.linePatterns,I);Z("connect",this.colors,I)}else{I.unique=false;I["boolean"]=false;for(var V=0;VA.m[T].maxFacLen){A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}else{A.m[T].maxFacLen=ad;A.m[T].maxFacChr=b;A.m[T].maxFacStr=W}}}if(P){return}var w,H,R;if(T=="z"){w="y";H="vars";R="Var"}if(T=="x"||T=="q"){w="y";H="smps";R="Smp"}if(T=="w"){w="w";H="smps";R="Smp"}var ag=0;var c=0;var aa="";if(l[w]){for(var V=0;Vthis.fullTextMeasureCheck){var L=l[w][H][V].toString().length;if(L>c){var E=this.HR(l[w][H][V],Y);if(E>ag){ag=E;c=L;aa=l[w][H][V]}}}else{if(l[w][H][V]!=null){var L=l[w][H][V].toString().length;if(L>=c){var E=this.HR(l[w][H][V].toString(),Y);if(E>ag){ag=E;c=L;aa=l[w][H][V].toString()}}}}}A[w]["max"+R+"Len"]=ag;A[w]["max"+R+"Chr"]=c;A[w]["max"+R+"Str"]=aa;A[w].vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";A[w].smps=this.nn(l.y.smps)?"World":this.RX(l.y.smps)?"USA":this.Ng(l.y.smps,true)?"Date":"String";if(A[w].smps=="Date"){A[w].date=this.vy(l.y.smps)}if(T=="x"){var ab={};var z=l.y.smps;for(var V=0;Vthis.fullTextMeasureCheck){var L=l.y.vars[V].toString().length;if(L>c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}else{if(l.y.vars[V]!=null){var L=l.y.vars[V].toString().length;if(L>=c){var E=this.HR(l.y.vars[V],Y);if(E>ag){ag=E;c=L;aa=l.y.vars[V]}}}}}A.y.maxVarLen=ag;A.y.maxVarChr=c;A.y.maxVarStr=aa;A.y.vars=this.nn(l.y.vars)?"World":this.RX(l.y.vars)?"USA":this.Ng(l.y.vars)?"Date":"String";if(!A.y.range){A.y.range={}}for(var V=0;Vag){ag=E;c=A[O].levels[V].toString().length;aa=A[O].levels[V]}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa}A[O].shapes=this.shapes;A[O].sizes=this.sizes;A[O].patterns=this.patterns}else{var S={};for(var V=0;Vag){ag=E;c=S[V].length;aa=S[V]}}A[O].maxLevLen=ag;A[O].maxLevChr=c;A[O].maxLevStr=aa;A[O].type="String";A[O].colors=[];var K=0;for(var V=0;V0){return true}else{if(a=="max"&&b.max&&b.max[0].length>0){return true}else{if(a=="min"&&b.min&&b.min[0].length>0){return true}else{if(a=="count"&&b.count&&b.count[0].length>0){return true}else{if(a=="mean"&&b.mean&&b.mean[0].length>0){return true}else{if(a=="median"&&b.median&&b.median[0].length>0){return true}else{if(a=="iqr"&&b.iqr1&&b.qtl1&&b.median&&b.qtl3&&b.iqr3&&b.median[0].length>0){return true}else{if(a=="raw"&&this.isRawData){return true}else{return false}}}}}}}}}}}}};this.we=function(aw,f,Q,ag,J){var W=this;var r=this.isDOE?this.data.l.data[this.layoutCurrent||0]:false;var t=this.isGroupedData&&!f&&this.data.w?this.data.w:this.data.y;var ah=this.graphType=="Scatter2D"&&this.scatterType=="visium"?CanvasXpress.cacheImages[this.backgroundImageMD5||this.va(this.backgroundImage)]:false;var w=this.Xs(true);var at=Number.POSITIVE_INFINITY;var K=Number.NEGATIVE_INFINITY;var A=Number.POSITIVE_INFINITY;var ab=Number.NEGATIVE_INFINITY;if(this.setMin!=null&&this.setMax!=null){this.minData=Number(this.setMin);this.maxData=Number(this.setMax);return}if(this.isGroupedData&&!aw&&!r){aw=this.graphType=="Boxplot"?"iqr":this.summaryType;if(this.graphType=="Boxplot"&&!this.isBoxplotCalc){this.cg(this.groupingFactors,false,false,false,true);t=this.data.w}}if(this.isGroupedData&&!f&&this.data.w&&!ag&&!r&&!this.layoutCurrent){for(var ak=0;ak=0?H:0;var Y=this.data.y.data[this.meterIndex];at=0;K=this.ob(Y,true)}else{if(w){var G=this.varIndices.length;for(var ak=0;ak=0){var ad=this.Ts(this.data.y.data[ap]);at=ad[0];K=ad[1]}else{at=0;K=1}}}else{if(aw=="gantt"){if(!this.data.gantt){this.isGanttDataFormated=false;this.ww()}var ak=this.as(this.ganttStart?this.ganttStart:this.xAxis[0]?this.xAxis[0]:this.data.y.vars[0]);this.ganttStart=this.data.y.vars[ak];var aj=this.as(this.ganttEnd?this.ganttEnd:this.xAxis[1]?this.xAxis[1]:this.data.y.vars[1]?this.data.y.vars[1]:this.data.y.vars[0]);this.ganttEnd=this.data.y.vars[aj]||this.data.y.vars[0];var ar=this.i4(this.data.gantt);at=ar[ak].sort(function(d,c){return d-c})[0];K=ar[aj].sort(function(d,c){return c-d})[0]}else{if(aw=="km"&&!f){if(!this.layoutValid){this.DO()}if(J=="y"){at=0;K=1}else{var ac=this.layoutValid&&this.meta.data.p.l.length?this.meta.data.p.l:this.meta.data.p.g;if(this.layoutValid&&this.meta.data.p.l.length){for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}}else{var G=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0){at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{at=Math.min(O-Z,at);K=Math.max(O+Z,K)}}else{if(Q){if(O>0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}}}}else{if(this.summaryType=="mean"&&!this.isRawData){var S=this.isDOE&&this.isDOE==1?this.data.y.vars.length:this.varIndices.length;for(var ak=0;ak0&&B>0){at=Math.min(D,at);K=Math.max(B,K)}}else{at=Math.min(D,at);K=Math.max(B,K)}}if(X){var T=X.length;for(var ai=0;ai0){at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}else{at=Math.min(X[ai],at);K=Math.max(X[ai],K)}}}}}}}}else{if(aw=="cor"){var o=this.correlationAxis=="variables"?this.varIndices:this.isGroupedData?this.grpIndices:this.smpIndices;var S=o.length;for(var ak=0;ak0){at=Math.min(O,at);K=Math.max(O,K)}}else{at=Math.min(O,at);K=Math.max(O,K)}}}}}else{if(r){var C=J=="xAxis"?0:1;if(this.graphType=="Scatter2D"){for(var ak=0;ak0){if(ag){var V=this.graphType=="Circular"&&this.showIdeogram;var F=V?[this.varIndices,this.smpIndices]:[this.smpIndices,this.varIndices];var y=F[0].length;K=0;at=0;ab=0;A=0;for(var ak=0;ak0){e+=O}else{if(O<0){g+=O}}}}K=Math.max(e,K);at=Math.min(g,at)}}else{var S=this.motionBy||(this.isDOE&&this.isDOE==1)?this.data.y.vars.length:this.varIndices.length;for(var 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aa=this.layoutValid?this.meta.data.s.layout[this.layoutCurrent||0]:this.meta.data.s;switch(this.scatterStreamType){case"mirror":at=-aa.maxY;K=aa.maxY;break;case"ridge":at=0;K=aa.maxY*2;break;case"proportional":at=0;K=1;break}}}}}else{if(this.graphType=="Scatter2D"&&J=="yAxis"&&(this.showLoessFit||this.showRegressionFit||this.showQuantileRegressionFit)){if(this.showLoessFit){this.l1()}if(this.showRegressionFit){this.ba()}if(this.showQuantileRegressionFit){this.Tw()}if(this.meta.data.s){var af=this.meta.data.s;if(af.minY!=null&&af.minYNumber.NEGATIVE_INFINITY){if(this.dataPointSizeScaleFactor){at=Math.min(at,af.minY);K=Math.max(K,af.maxY)}else{at=af.minY;K=af.maxY}}}}}}}}}}if(this.decorations){if(this.decorations.error){for(var ak=0;ak=f&&d<=b))&&(e===null||(c>=e&&c<=a))){}else{if(q){this.filterFitIndices[q[h]]=true}else{this.filterFitIndices[r]=true}}}}for(var h=0;h=f&&d<=b))&&(e===null||(c>=e&&c<=a))){j.push(d);g.push(c)}}return[j,g]};this.WL=function(){var I=this;var K=[];var 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ap=I.data;if(!Z.hasOwnProperty("Factor")){Z.Factor={}}var ai=0;for(var am=0;amthis.maxDOENumber){break}}}else{for(var T=0;Tthis.maxDOENumber){break}}}o=true}}}else{if(this.graphType.match(/Scatter|Map/)){if(this.segregateVariablesBy.length&&this.meta.data.z&&this.meta.data.z.hasOwnProperty(this.segregateVariablesBy[0])){var Z=I.meta.data.s.density;var V=A(0);if(this.segregateVariablesBy.length==2||(this.showHistogram!=true&&this.showHistogram!=this.segregateVariablesBy[0])){var e=this.segregateVariablesBy.length==2?this.segregateVariablesBy[1]:this.showHistogram;var U=this.segregateVariablesBy.length==2?A(1):A(false,e);K=[];var h=this.meta.data.z[this.segregateVariablesBy[0]].levels;var f=this.meta.data.z[e].levels;var X=this.data;var N=0;for(var T=0;T5){try{b.loess[o+":"+h[d]]=this.Ed([q[0],q[1]],"Loess:"+o+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.loess[o+":"+h[d]].range[3])}catch(c){f.push(["setLoessData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.loess[o]=this.Ed([q[0],q[1]],"Global:"+o+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.loess[o].range[2]);b.maxY=Math.max(b.maxY,b.loess[o].range[3])}catch(c){f.push(["setLoessData",q[0].length,o,c])}}}}}};this.ba=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={regression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("regression")){this.meta.data.s.regression={}}}if(this.layoutValid&&this.meta.data.s.layout&&this.data.l&&this.data.l.comp&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e3){b.regression[p+":"+h[c]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[c]);b.minY=Math.min(b.minY,b.regression[p+":"+h[c]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[c]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[c],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,e,d,o);if(s[0].length>3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}else{for(var e=0;e3){b.regression[p+":"+h[d]]=this.Wg(s[0],s[1],"Regression:"+p+":"+h[d]+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p+":"+h[d]][4][2]);b.maxY=Math.max(b.maxY,b.regression[p+":"+h[d]][4][3])}else{f.push(["setRegressionData",s[0].length,p+":"+h[d],"Less than 3 values"])}}}else{var o=g!=null?this.data.l.comp[g]:false;var s=this.dL(g,l,r,o);if(s[0].length>=3){b.regression[p]=this.Wg(s[0],s[1],"Global:"+p+(g!=null?":"+g:""));b.minY=Math.min(b.minY,b.regression[p][4][2]);b.maxY=Math.max(b.maxY,b.regression[p][4][3])}else{f.push(["setRegressionData",s[0].length,p,"Less than 3 values"])}}}}}};this.Tw=function(a,g){var f=this.meta.console;if(!a){if(!this.meta.data.s){this.meta.data.s={quantileRegression:{},layout:[]}}else{if(this.meta.data.s&&!this.meta.data.s.hasOwnProperty("quantileRegression")){this.meta.data.s.quantileRegression={}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var e=0;e5){try{b.quantileRegression[o+":"+h[d]]=this.Sm(q[0],q[1],this.quantiles,"QuantileRegression:"+o+":"+h[d]+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o+":"+h[d]])){b.minY=Math.min(b.minY,b.quantileRegression[o+":"+h[d]].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o+":"+h[d]].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o+":"+h[d],c])}}}}else{var l=g!=null?this.data.l.comp[g]:false;var q=this.dL(g,k,r,l);if(q[0].length>5){try{b.quantileRegression[o]=this.Sm(q[0],q[1],this.quantiles,"Global:"+o+(g!=null?":"+g:""));if(this.gZ(b.quantileRegression[o])){b.minY=Math.min(b.minY,b.quantileRegression[o].range[2]);b.maxY=Math.max(b.maxY,b.quantileRegression[o].range[3])}}catch(c){f.push(["setQuantileRegressionData",q[0].length,o,c])}}}}}};this.yc=function(b,o){if(!b){if(!this.meta.data.s||(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length)){if(!this.meta.data.s){this.meta.data.s={areas:{},layout:[]}}}if(this.layoutValid&&this.meta.data.s.layout.length!=this.data.l.comp.length){for(var f=0;f=0){t[0].push(l[r]);t[1].push(d[r]);s=r}else{if(e==0){t[0].push(h[e]);t[1].push(h[e]=0){g[0].push(r[q]);g[1].push(E[q])}else{g[0].push(k[w]);g[1].push(0)}}if(r.length>5){this.loessSpan=this.scatterStreamBandwidth?Math.max(0.1,this.scatterStreamBandwidth-0.45):0.3;try{var t=this.Ed([g[0],g[1]],"Stream"+s[y]+(D!=null?D:""));for(var w=0;w0){this.Ab();for(var c=0;c=1000){alert("Cannot exp transform values > 1000");return false}e=e=="exp2"?"exp2":"exp10"}}if(!g.trans){g.trans=[]}if(!g.tstdev){g.tstdev=[]}var f=this.motionBy?this.data.y.vars.length:this.isGroupedData?this.data.y.vars.length:!this.isDOE?this.data.y.vars.length:this.varIndices.length;for(var c=0;c0){var c=this.transformBase==2?"ratio2":"ratio10";var z=a.data[k][s]/e;var d=a.stdev[k][s];if(c=="ratio2"){a.trans[k][s]=Math.log(z)/Math.LN2;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN2}}else{if(c=="ratio10"){a.trans[k][s]=Math.log(z)/Math.LN10;if(d&&d>0){a.tstdev[k][s]=Math.log(d)/Math.LN10}}}}}}};this.Ph=function(s,p,o){var c=this.isGroupedData&&!this.graphType.match(/dotplot|boxplot/i)?this.data.w:this.data.y;var k=this.isGroupedData?false:true;var q;p=p?p:this.transformAxis;if(p=="samples"){for(var g=0;g1&&ah.includes("__FACTOR__")){ah=ah.filter(function(a){return a!="__FACTOR__"})}for(var Y=0;Y0?q.join(" :: "):"";if(!w.hasOwnProperty(B)){af.w.smps.push(B);P[B]=U;w[B]=[]}w[B].push(y)}this.isGroupedData=true;if(af.w.smps.length<1){af.w.smps=z;this.H9({func:"groupSamples",par:[ah,R,r,ac,c,C,ai]});return}if(this.isCxplot&&ah.length==1&&this.meta.data.x&&this.meta.data.x.hasOwnProperty(ah[0])&&this.meta.data.x[ah[0]].levels&&this.meta.data.x[ah[0]].type!="Numeric"){if(this.sortIncludeEmpty){if(this.meta.config.user.aes.hasOwnProperty("meta")){if(ah[0]==this.meta.config.user.aes.x&&this.meta.config.user.aes.meta.hasOwnProperty("xLabels")){var Z=this.eI(this.meta.config.user.aes.meta.xLabels);var ab=false;for(var Y=0;Y360){this.circularArc=360}else{if(this.circularArc<90){this.circularArc=90}}var y=this.circularArc*(Math.PI*2)/360;var p=(y-this.So(this.circularArcSectorSeparation)*(this.circularArc==360?B:B-1))/k;var h=[];var f=[];var C=0;for(var F=0;F=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}this.FV("y");this.YS(true,true);this.aS()}if(!c){this.H9({func:"uncountData",par:[]})}};this.K6=function(b,e){if(b){this.data.y.smps.push("__SEQ__");for(var a=0;a=0){this.data.y.smps.splice(a,1);for(var a=0;a=0){this.data.y.vars.splice(a,1);this.data.y.data.splice(a,1)}}this.FV("y");this.YS(true,true);this.aS();if(!c){this.H9({func:"unsequenceData",par:[]})}};this.qR=function(){var u=this.isDOE?this.data.l.data[this.layoutCurrent]:false;var g=this.isDOE?u.y.data[0]:this.eI(this.data.y.data[this.meterIndex]);var t=this.isDOE?u.y.meter.group:this.groupingFactors.length?this.groupingFactors[0]:false;var e=this.isDOE?u.x[t]:t?this.eI(this.data.x[t]):false;var h=this.isDOE?u.y.meter.summary:this.summaryType;var c=this.isDOE?u.y.meter.topology:this.meterTopology;var p=t&&(!this.isDOE||this.isDOE==1)?this.meta.data.x[t]:t&&this.isDOE>1?this.meta.data.z[t]:false;var j=this.isDOE&&this.isDOE>1?this.varIndices:this.smpIndices;this.isMeterSummarized={data:g,count:g.length,sum:this.XX(g),mean:this.nd(g),max:this.ob(g)};var q=this.isMeterSummarized;var a=this.rangeSegments.length&&!this.isDOE?this.rangeSegments[this.rangeSegments.length-1]:false;switch(h){case"count":case"countTotal":q.value=q.count;q.scale=this[this.axisAlgorithm](0,a||q.count,5,false,this.axisWilkinsonLoose);q.reference=q.count;break;case"average":case"mean":case"raw":q.value=q.mean;q.scale=this[this.axisAlgorithm](0,a||q.max,5,false,this.axisWilkinsonLoose);q.reference=q.max;break;case"sum":case"sumTotal":q.value=q.sum;q.scale=this[this.axisAlgorithm](0,a||q.sum,5,false,this.axisWilkinsonLoose);q.reference=q.sum;break;case"percentage":case"percentageTotal":q.value=100;q.scale=this[this.axisAlgorithm](0,a||100,5,false,this.axisWilkinsonLoose);q.reference=100;break}q.range=a||q.scale[q.scale.length-1];var k=this.TM();var b=this.isDOE?this.layoutWidth:this.width-(this.marginLeft+this.marginRight);var o=(this.isDOE?this.layoutHeight:this.height)-(k+this.marginTop+this.marginBottom);if(t){if(p&&p.type=="String"){q.n=p.levels.length;let ratio=b/o;let inverseRatio=o/b;let condition=q.n<2&&c=="auto";let condition2=c=="auto"&&ratio>q.n-0.5;let condition3=c=="auto"&&inverseRatio>q.n-0.5;let condition4=c=="horizontal";let condition5=c=="vertical";if(condition||condition2||condition4){q.cols=q.n;q.rows=1}else{if(condition3||condition5){q.cols=1;q.rows=q.n}else{q.cols=Math.ceil(Math.sqrt(q.n));q.rows=Math.ceil(q.n/q.cols)}}q[t]={};q.levels=p.levels;for(var f=0;f0){l[g]++}}}if(!this.data.x){this.data.x={}}this.data.x.Sets=l;a=a.sort(function(s,j){return l[j]-l[s]});if(!this.upSetSets.length){a=a.splice(0,this.nUpSets)}this.isUpSetSumarized.vars=this.eI(a.reverse());a=this.iT(a);var b=[];var o=[];var r=[];var c=[];var e={};var h={};var k=[];for(var g=0;g0){b[g]++;if(a.hasOwnProperty(f)){o.push(f)}}}var q=o.join(":");if(!e.hasOwnProperty(q)){e[q]=[]}e[q].push(g)}this.isUpSetSumarized.inter=e;var p=[];for(var g in e){var d=g.split(":").length;h[g]=e[g].length;if(g!=""){p.push(g)}for(var f=0;f0){var k=[];var g=[];for(var h=0;h0){}this.treemapBy=k}var p=this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Map|Circular/)||this.graphType=="Tree";if(this.shapeBy&&!this.isMultidimensionalData&&!p){c+="shapeBy changed to false (shapeBy not support in"+this.graphType+")\n";this.shapeBy=false}else{if(this.shapeBy&&this.groupingFactors.length>1&&!p){c+="shapeBy changed to variable (multiple grouping factors not allowed)\n";this.shapeBy="variable"}else{if(this.shapeBy&&this.groupingFactors.length==1&&this.shapeBy!=this.groupingFactors[0]&&!p){c+="shapeBy changed to variable (grouping factor should the same as shapeBy)\n";this.shapeBy="variable"}}}if(this.sizeBy&&!this.isMultidimensionalData&&!p){c+="sizeBy changed to false (sizeBy not support in"+this.graphType+")\n";this.sizeBy=false}else{if(this.sizeBy&&this.groupingFactors.length>1&&!p){c+="sizeBy changed to variable (multiple grouping factors not allowed)\n";this.sizeBy="variable"}else{if(this.sizeBy&&this.groupingFactors.length==1&&this.sizeBy!=this.groupingFactors[0]&&!p){c+="sizeBy changed to variable (grouping factor should the same as sizeBy)\n";this.sizeBy="variable"}}}if(this.colorBy&&this.graphType=="Heatmap"&&!this.isMultidimensionalData){this.lX(this.colorBy)}else{if(this.graphType=="Heatmap"&&this.heatmapType=="split"&&b){this.cq()}else{if(this.colorBy&&this.groupingFactors.length>1&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap/)&&!this.isCxplot){c+="colorBy changed to variable (multiple grouping factors not allowed)\n";this.colorBy="variable"}else{if(this.colorBy&&this.groupingFactors.length==1&&this.colorBy!=this.groupingFactors[0]&&!this.graphType.match(/Boxplot|Dotplot|Gantt|Scatter|Stacked|Treemap|Line/)&&this.barType!="swimmer"){if(this.toDoPivot){this.colorBy=false}else{c+="colorBy changed to variable (grouping factor should the same as colorBy)\n";this.colorBy="variable"}}}}}if((this.shapeBy||this.sizeBy||this.patternBy||this.outlineBy)&&!this.colorBy&&!this.isMultidimensionalData&&!this.graphType=="Heatmap"&&!this.isCxplot){this.colorBy="variable"}else{if(!this.shapeBy&&!this.sizeBy&&!this.patternBy&&this.colorBy=="variable"&&this.graphType!="Map"){this.colorBy=o()}}if(this.shapeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.sizeBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.patternBy=="variable"&&!this.colorBy&&!this.Uv()){this.colorBy="variable"}if(this.stackBy&&!this.colorBy){this.colorBy=this.stackBy}else{if(this.stackBy&&this.colorBy&&this.stackBy!=this.colorBy){c+="colorBy changed to stackBy (remove stackBy to color by different factor)\n";this.colorBy=this.stackBy}}if(this.dodgeBy&&!this.colorBy){this.colorBy=this.dodgeBy}else{if(this.dodgeBy&&this.colorBy&&this.dodgeBy!=this.colorBy){c+="colorBy changed to dodgeBy (remove dodgeBy to color by different factor)\n";this.colorBy=this.dodgeBy}}if(this.lineBy&&!this.colorBy&&this.isGroupedData){}else{if(this.lineBy&&this.colorBy&&this.lineBy!=this.colorBy&&this.isGroupedData){c+="colorBy changed to lineBy (remove lineBy to color by different factor)\n";this.colorBy=this.lineBy}else{if(this.lineBy&&!this.isGroupedData&&this.graphType!="Scatter2D"){c+="Data needs to be grouped";this.lineBy=false}}}if(c!=""){this.n6(10,10,c,3000)}if(this.colorBy||this.shapeBy||this.sizeBy||this.lineBy){var q=["colorBy","shapeBy","lineBy"];var t=[];for(var h=0;h=0&&o.w.grps[E]){for(var g=0;g1){return false}}}return true};var f=function(){if(!e.patternBy){if(G>e.colors.length-1&&!e.colorBy){return e[z[F]][Math.floor(G/e.colors.length)]}else{return e[z[F]][0]}}else{return e[z[F]][0]}};var r=F&&this[z[F]]?this[z[F]].length:false;if(G!=null&&E!=null&&u&&o.y.hasOwnProperty(u)){y=o.y[u][G][E];x=H[u];j=x.type}else{if(E!=null&&u&&o.x&&o.x.hasOwnProperty(u)){x=H.x[u];if(C||!this.isGroupedData){j=x.type;y=this.graphType=="Gantt"?o.x[u][E]:this.isGroupedData?o.w.smps[E]:o.x[u][E];if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(F=="colorSmpDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}}}else{if((A&&(this.groupingFactors[0]==u||d()))||(!A&&this.isGroupedData&&this.isCxplot&&this.groupingFactors.length>1)){j=x.type;y=E!==false&&E>=0&&o.w.grps[E]?o.x[u][o.w.grps[E][0]]:false;if(y&&F.match(/color|patternBy/)){if(x[F]&&x[F].hasOwnProperty(y)){return x[F][y]}else{if(x[z[F]]){return x[z[F]][x.order[y]%r]}else{return this[z[F]][x.order[y]%r]}}}else{return x[z[F]]?x[z[F]][0]:F.match(/color/)?this[z[F]][0]:F=="patternBy"?f():this[z[F]][0]}}else{return G!=null&&F.match(/color/)?this[z[F]][G%r]:F=="patternBy"?f():this[z[F]][0]}}}else{if(G!=null&&u&&o.z&&o.z.hasOwnProperty(u)){x=H.z[u];j=x.type;y=o.z[u][G];if(x[F]&&(x[F].hasOwnProperty(y)||x[F][y])){return x[F][y]}else{if(x[F]&&(x[F].hasOwnProperty(y+"\x00")||x[F][y+"\x00"])){return x[F][y+"\x00"]}else{if(x[F]&&x[F][y.replace("\x00","")]){return x[F][y.replace("\x00","")]}else{if(F=="colorVarDendrogramBy"&&x.colorBy&&x.colorBy.hasOwnProperty(y)){return x.colorBy[y]}else{if(x[F]&&F=="linePatterns"&&x.order&&x.order.hasOwnProperty(y)){return x[F][x.order[y]%this[F].length]}}}}}}else{if(G!=null&&E!=null&&F&&((this.isGroupedData&&H.w.smps.hasOwnProperty(F))||(!this.isGroupedData&&H.y.range.hasOwnProperty(F)))){y=o.y.data[G][E];x=H.y.range[F];j=H.y.type}else{if(G!=null&&!this.isGroupedData&&u&&H.y.range.hasOwnProperty(u)){x=H.y.range[u];j=x.type;k=E!=null?false:this.sF(u);y=E!=null?o.y.data[G][E]:o.y.data[G]?o.y.data[G][k>=0?k:0]:0;if(H.modified&&H.modified.z&&H.modified.z[u]){return 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a=c.toLowerCase().replace(/ /g,"");switch(a){case"grey":case"gray":case"igray":case"ggplot":return CanvasXpress.themeDef.grey;case"bw":case"blackandwhite":return CanvasXpress.themeDef.bw;case"linedraw":return CanvasXpress.themeDef.linedraw;case"light":return CanvasXpress.themeDef.light;case"dark":return CanvasXpress.themeDef.dark;case"minimal":return CanvasXpress.themeDef.minimal;case"classic":return CanvasXpress.themeDef.classic;case"void":case"void0":return CanvasXpress.themeDef.void0;case"economist":return CanvasXpress.themeDef.economist;case"excel":return CanvasXpress.themeDef.excel;case"solarized":return CanvasXpress.themeDef.solarized;case"paulTol":case"paultol":case"ptol":return CanvasXpress.themeDef.ptol;case"highcharts":return CanvasXpress.themeDef.highcharts;case"wallstreetjournal":case"wallstreet":case"wsj":return CanvasXpress.themeDef.wsj;case"tableau":return CanvasXpress.themeDef.tableau;case"stata":return CanvasXpress.themeDef.stata;case"ggblanket":return CanvasXpress.themeDef.ggblanket;case"cx":case"canvasxpress":return CanvasXpress.themeDef.cx;case"cxdark":case"canvasxpressdark":return CanvasXpress.themeDef.cxdark;case"cx2":case"canvasxpresstraditional":return CanvasXpress.themeDef.grey;default:var b=this.eI(CanvasXpress.themeDef.light);b["panel.border.colour"]=null;return b}};this.L3=function(b){if(!b){b="x"}var e=["AxisShow","Axis2Show","AxisTitleColor","AxisTitleScaleFontFactor","AxisTextColor","AxisTextScaleFontFactor","AxisTicksShow","AxisTicksColor","AxisTicksLength","AxisTicksWidth","AxisLineBottomShow","AxisLineBottomColor","AxisLineBottomLineType","AxisLineBottomWidth","AxisLineTopShow","AxisLineTopColor","AxisLineTopLineType","AxisLineTopWidth","AxisGridMajorShow","AxisGridMajorColor","AxisGridMajorLineType","AxisGridMajorWidth","AxisGridMinorShow","AxisGridMinorColor","AxisGridMinorLineType","AxisGridMinorWidth"];var f=["r","z"];for(var d=0;d0&&!this.skipTransition&&this.showTransition){delete 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e&&e.classList?e.classList.contains(n):false};this.X0=function(e,n){if(e){e.classList.add(n)}};this.Tg=function(e,n){if(e){e.classList.remove(n)}};this.Rs=function(e,r,a){if(e){e.classList.remove(r);e.classList.add(a)}};this.md=function(e){var s="";var o=getComputedStyle(e);for(var i=0;i0?1:-1)*Math.floor(Math.abs(number))};var maxSafeInteger=Math.pow(2,53)-1;var toLength=function(value){var len=toInteger(value);return Math.min(Math.max(len,0),maxSafeInteger)};return function from(arrayLike){var C=this;var items=Object(arrayLike);if(arrayLike==null){throw new TypeError("Array.from requires an array-like object - not null or undefined")}var mapFn=arguments.length>1?arguments[1]:void undefined;var T;if(typeof mapFn!=="undefined"){if(!isCallable(mapFn)){throw new TypeError("Array.from: when provided, the second argument must be a function")}if(arguments.length>2){T=arguments[2]}}var len=toLength(items.length);var A=isCallable(C)?Object(new C(len)):new Array(len);var k=0;var kValue;while(k>>0;var start=arguments[1];var relativeStart=start>>0;var k=relativeStart<0?Math.max(len+relativeStart,0):Math.min(relativeStart,len);var end=arguments[2];var relativeEnd=end===undefined?len:end>>0;var finl=relativeEnd<0?Math.max(len+relativeEnd,0):Math.min(relativeEnd,len);while(k>>0;if(typeof callback!=="function"){throw new TypeError(callback+" is not a function")}if(arguments.length>1){T=arguments[1]}A=new Array(len);k=0;while(k>>0;if(typeof predicate!=="function"){throw new TypeError("predicate must be a function")}var thisArg=arguments[1];var k=0;while(k>>0;if(len===0){return false}var n=fromIndex|0;var k=Math.max(n>=0?n:len-Math.abs(n),0);function sameValueZero(x,y){return x===y||(typeof x==="number"&&typeof y==="number"&&isNaN(x)&&isNaN(y))}while(kA){var G=A;A=u;u=G}}var o=this.Fe(u,A,4);u=o[0];A=o[o.length-1];var y=A-u;var a=(((y*1000000)-(parseInt(y)*1000000))/1000000).toString().replace(/\./,"").length-1;var e=Math.pow(1/10,(a+1));var C=u>0?Math.log10(u):u==0?0:null;var E=A>0?Math.log10(A):A==0?0:null;var c=[];var Q="CanvasXpressRangeSlider";if(C!=null&&E!=null){var I=this.Fe(C,E,4);for(var B=0;B1){m=l;m.width=arguments[0];m.height=arguments[1]}else{if(!n){m=l}else{m=n}}if(!(this instanceof k)){return new k(m)}this.width=m.width||l.width;this.height=m.height||l.height;this.desc=m.desc||l.desc;this.enableMirroring=m.enableMirroring!==undefined?m.enableMirroring:l.enableMirroring;this.canvas=this;this.__document=m.document||document;if(m.ctx){this.__ctx=m.ctx}else{this.__canvas=this.__document.createElement("canvas");this.__ctx=this.__canvas.getContext("2d")}this.__setDefaultStyles();this.__stack=[this.__getStyleState()];this.__groupStack=[];this.__root=this.__document.createElementNS("http://www.w3.org/2000/svg","svg");this.__root.setAttribute("version",1.1);this.__root.setAttribute("xmlns","http://www.w3.org/2000/svg");this.__root.setAttributeNS("http://www.w3.org/2000/xmlns/","xmlns:xlink","http://www.w3.org/1999/xlink");this.__root.setAttribute("width",this.width);this.__root.setAttribute("height",this.height);this.__root.setAttribute("desc",this.desc);this.__ids={};this.__defs=this.__document.createElementNS("http://www.w3.org/2000/svg","defs");this.__root.appendChild(this.__defs);this.__currentElement=this.__document.createElementNS("http://www.w3.org/2000/svg","g");this.__root.appendChild(this.__currentElement)};k.prototype.__createElement=function(l,p,r){if(typeof 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-
-
-
-

Articles

+ +
+
+
+
+

Articles

All vignettes

-

+
-
DrugBank Database XML Parser
+
Unlocking DrugBank: Parsing and Visualizing Mechanistic Data
+
+
Introducing dbparser 2.2.0
+
+
Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES
-
-
+
-
+ - - diff --git a/docs/articles/index.md b/docs/articles/index.md new file mode 100644 index 00000000..f50bcb29 --- /dev/null +++ b/docs/articles/index.md @@ -0,0 +1,10 @@ +# Articles + +### All vignettes + +- [Unlocking DrugBank: Parsing and Visualizing Mechanistic + Data](https://docs.ropensci.org/dbparser/articles/dbparser.md): +- [Introducing dbparser + 2.2.0](https://docs.ropensci.org/dbparser/articles/dbparser_2_2.md): +- [Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and + TWOSIDES](https://docs.ropensci.org/dbparser/articles/drugbank_nside.md): diff --git a/docs/authors.html b/docs/authors.html index 3bce749f..8c20d7be 100644 --- a/docs/authors.html +++ b/docs/authors.html @@ -1,117 +1,94 @@ -Authors and Citation • dbparser - - -
-
-
-
-
-

Authors

-
- - +
+

Authors

+
  • -

    Mohammed Ali. Author, maintainer. +

    Mohammed Ali. Author, maintainer.

  • -

    Ali Ezzat. Author. +

    Ali Ezzat. Author.

  • -

    Hao Zhu. Reviewer. +

    Hao Zhu. Reviewer.

  • -

    Emma Mendelsohn. Reviewer. +

    Emma Mendelsohn. Reviewer.

-
-
-

Citation

- Source: inst/CITATION -
-
+
+

Citation

+

Source: inst/CITATION

-

Mohammed Ali, Ali Ezzat (). - dbparser: DrugBank Database XML Parser. R package version 2.0.3.

- 
@Manual{,
+      
Mohammed Ali, Ali Ezzat ().
+                           dbparser: DrugBank Database XML Parser. R package version 2.2.1.

+      
@Manual{,
   title = {DrugBank Database XML Parser},
   author = {Mohammed Ali and Ali Ezzat},
   organization = {Interstellar for Consultinc inc.},
-  note = {R package version 2.0.3},
+  note = {R package version 2.2.1},
   url = {https://CRAN.R-project.org/package=dbparser},
 }

+
-
- -
- +
-
+ - - diff --git a/docs/authors.md b/docs/authors.md new file mode 100644 index 00000000..84cb3569 --- /dev/null +++ b/docs/authors.md @@ -0,0 +1,27 @@ +# Authors and Citation + +## Authors + +- **[Mohammed Ali](http://mohammedfcis.github.io)**. Author, maintainer. + +- **Ali Ezzat**. Author. + +- **Hao Zhu**. Reviewer. + +- **Emma Mendelsohn**. Reviewer. + +## Citation + +Source: +[`inst/CITATION`](https://github.com/ropensci/dbparser/blob/HEAD/inst/CITATION) + +Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. R +package version 2.2.1. + + @Manual{, + title = {DrugBank Database XML Parser}, + author = {Mohammed Ali and Ali Ezzat}, + organization = {Interstellar for Consultinc inc.}, + note = {R package version 2.2.1}, + url = {https://CRAN.R-project.org/package=dbparser}, + } diff --git a/docs/deps/bootstrap-5.3.1/bootstrap.bundle.min.js b/docs/deps/bootstrap-5.3.1/bootstrap.bundle.min.js new file mode 100644 index 00000000..e8f21f70 --- /dev/null +++ b/docs/deps/bootstrap-5.3.1/bootstrap.bundle.min.js @@ -0,0 +1,7 @@ +/*! + * Bootstrap v5.3.1 (https://getbootstrap.com/) + * Copyright 2011-2023 The Bootstrap Authors (https://github.com/twbs/bootstrap/graphs/contributors) + * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE) + */ +!function(t,e){"object"==typeof exports&&"undefined"!=typeof module?module.exports=e():"function"==typeof define&&define.amd?define(e):(t="undefined"!=typeof globalThis?globalThis:t||self).bootstrap=e()}(this,(function(){"use strict";const t=new Map,e={set(e,i,n){t.has(e)||t.set(e,new Map);const s=t.get(e);s.has(i)||0===s.size?s.set(i,n):console.error(`Bootstrap doesn't allow more than one instance per element. 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H{constructor(t){super(),this._config=this._getConfig(t),this._isAppended=!1,this._element=null}static get Default(){return Xi}static get DefaultType(){return Yi}static get NAME(){return Vi}show(t){if(!this._config.isVisible)return void g(t);this._append();const e=this._getElement();this._config.isAnimated&&d(e),e.classList.add(Ki),this._emulateAnimation((()=>{g(t)}))}hide(t){this._config.isVisible?(this._getElement().classList.remove(Ki),this._emulateAnimation((()=>{this.dispose(),g(t)}))):g(t)}dispose(){this._isAppended&&(N.off(this._element,Qi),this._element.remove(),this._isAppended=!1)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_configAfterMerge(t){return t.rootElement=r(t.rootElement),t}_append(){if(this._isAppended)return;const t=this._getElement();this._config.rootElement.append(t),N.on(t,Qi,(()=>{g(this._config.clickCallback)})),this._isAppended=!0}_emulateAnimation(t){_(t,this._getElement(),this._config.isAnimated)}}const Gi=".bs.focustrap",Ji=`focusin${Gi}`,Zi=`keydown.tab${Gi}`,tn="backward",en={autofocus:!0,trapElement:null},nn={autofocus:"boolean",trapElement:"element"};class sn extends H{constructor(t){super(),this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}static get Default(){return en}static get DefaultType(){return nn}static get NAME(){return"focustrap"}activate(){this._isActive||(this._config.autofocus&&this._config.trapElement.focus(),N.off(document,Gi),N.on(document,Ji,(t=>this._handleFocusin(t))),N.on(document,Zi,(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,N.off(document,Gi))}_handleFocusin(t){const{trapElement:e}=this._config;if(t.target===document||t.target===e||e.contains(t.target))return;const i=z.focusableChildren(e);0===i.length?e.focus():this._lastTabNavDirection===tn?i[i.length-1].focus():i[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?tn:"forward")}}const on=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",rn=".sticky-top",an="padding-right",ln="margin-right";class cn{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,an,(e=>e+t)),this._setElementAttributes(on,an,(e=>e+t)),this._setElementAttributes(rn,ln,(e=>e-t))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,an),this._resetElementAttributes(on,an),this._resetElementAttributes(rn,ln)}isOverflowing(){return this.getWidth()>0}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t).getPropertyValue(e);t.style.setProperty(e,`${i(Number.parseFloat(s))}px`)}))}_saveInitialAttribute(t,e){const i=t.style.getPropertyValue(e);i&&F.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=F.getDataAttribute(t,e);null!==i?(F.removeDataAttribute(t,e),t.style.setProperty(e,i)):t.style.removeProperty(e)}))}_applyManipulationCallback(t,e){if(o(t))e(t);else for(const i of z.find(t,this._element))e(i)}}const hn=".bs.modal",dn=`hide${hn}`,un=`hidePrevented${hn}`,fn=`hidden${hn}`,pn=`show${hn}`,mn=`shown${hn}`,gn=`resize${hn}`,_n=`click.dismiss${hn}`,bn=`mousedown.dismiss${hn}`,vn=`keydown.dismiss${hn}`,yn=`click${hn}.data-api`,wn="modal-open",An="show",En="modal-static",Tn={backdrop:!0,focus:!0,keyboard:!0},Cn={backdrop:"(boolean|string)",focus:"boolean",keyboard:"boolean"};class On extends W{constructor(t,e){super(t,e),this._dialog=z.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._isTransitioning=!1,this._scrollBar=new cn,this._addEventListeners()}static get Default(){return Tn}static get DefaultType(){return Cn}static get NAME(){return"modal"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||N.trigger(this._element,pn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isTransitioning=!0,this._scrollBar.hide(),document.body.classList.add(wn),this._adjustDialog(),this._backdrop.show((()=>this._showElement(t))))}hide(){this._isShown&&!this._isTransitioning&&(N.trigger(this._element,dn).defaultPrevented||(this._isShown=!1,this._isTransitioning=!0,this._focustrap.deactivate(),this._element.classList.remove(An),this._queueCallback((()=>this._hideModal()),this._element,this._isAnimated())))}dispose(){N.off(window,hn),N.off(this._dialog,hn),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new Ui({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_showElement(t){document.body.contains(this._element)||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0;const e=z.findOne(".modal-body",this._dialog);e&&(e.scrollTop=0),d(this._element),this._element.classList.add(An),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,N.trigger(this._element,mn,{relatedTarget:t})}),this._dialog,this._isAnimated())}_addEventListeners(){N.on(this._element,vn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():this._triggerBackdropTransition())})),N.on(window,gn,(()=>{this._isShown&&!this._isTransitioning&&this._adjustDialog()})),N.on(this._element,bn,(t=>{N.one(this._element,_n,(e=>{this._element===t.target&&this._element===e.target&&("static"!==this._config.backdrop?this._config.backdrop&&this.hide():this._triggerBackdropTransition())}))}))}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(wn),this._resetAdjustments(),this._scrollBar.reset(),N.trigger(this._element,fn)}))}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(N.trigger(this._element,un).defaultPrevented)return;const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._element.style.overflowY;"hidden"===e||this._element.classList.contains(En)||(t||(this._element.style.overflowY="hidden"),this._element.classList.add(En),this._queueCallback((()=>{this._element.classList.remove(En),this._queueCallback((()=>{this._element.style.overflowY=e}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;if(i&&!t){const t=p()?"paddingLeft":"paddingRight";this._element.style[t]=`${e}px`}if(!i&&t){const t=p()?"paddingRight":"paddingLeft";this._element.style[t]=`${e}px`}}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=On.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}N.on(document,yn,'[data-bs-toggle="modal"]',(function(t){const e=z.getElementFromSelector(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),N.one(e,pn,(t=>{t.defaultPrevented||N.one(e,fn,(()=>{a(this)&&this.focus()}))}));const i=z.findOne(".modal.show");i&&On.getInstance(i).hide(),On.getOrCreateInstance(e).toggle(this)})),R(On),m(On);const xn=".bs.offcanvas",kn=".data-api",Ln=`load${xn}${kn}`,Sn="show",Dn="showing",$n="hiding",In=".offcanvas.show",Nn=`show${xn}`,Pn=`shown${xn}`,Mn=`hide${xn}`,jn=`hidePrevented${xn}`,Fn=`hidden${xn}`,Hn=`resize${xn}`,Wn=`click${xn}${kn}`,Bn=`keydown.dismiss${xn}`,zn={backdrop:!0,keyboard:!0,scroll:!1},Rn={backdrop:"(boolean|string)",keyboard:"boolean",scroll:"boolean"};class qn extends W{constructor(t,e){super(t,e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get Default(){return zn}static get DefaultType(){return Rn}static get NAME(){return"offcanvas"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||N.trigger(this._element,Nn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._backdrop.show(),this._config.scroll||(new cn).hide(),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add(Dn),this._queueCallback((()=>{this._config.scroll&&!this._config.backdrop||this._focustrap.activate(),this._element.classList.add(Sn),this._element.classList.remove(Dn),N.trigger(this._element,Pn,{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(N.trigger(this._element,Mn).defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.add($n),this._backdrop.hide(),this._queueCallback((()=>{this._element.classList.remove(Sn,$n),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._config.scroll||(new cn).reset(),N.trigger(this._element,Fn)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_initializeBackDrop(){const t=Boolean(this._config.backdrop);return new Ui({className:"offcanvas-backdrop",isVisible:t,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:t?()=>{"static"!==this._config.backdrop?this.hide():N.trigger(this._element,jn)}:null})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_addEventListeners(){N.on(this._element,Bn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():N.trigger(this._element,jn))}))}static jQueryInterface(t){return this.each((function(){const e=qn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}N.on(document,Wn,'[data-bs-toggle="offcanvas"]',(function(t){const e=z.getElementFromSelector(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),l(this))return;N.one(e,Fn,(()=>{a(this)&&this.focus()}));const i=z.findOne(In);i&&i!==e&&qn.getInstance(i).hide(),qn.getOrCreateInstance(e).toggle(this)})),N.on(window,Ln,(()=>{for(const t of z.find(In))qn.getOrCreateInstance(t).show()})),N.on(window,Hn,(()=>{for(const t of z.find("[aria-modal][class*=show][class*=offcanvas-]"))"fixed"!==getComputedStyle(t).position&&qn.getOrCreateInstance(t).hide()})),R(qn),m(qn);const Vn={"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},Kn=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Qn=/^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i,Xn=(t,e)=>{const i=t.nodeName.toLowerCase();return e.includes(i)?!Kn.has(i)||Boolean(Qn.test(t.nodeValue)):e.filter((t=>t instanceof RegExp)).some((t=>t.test(i)))},Yn={allowList:Vn,content:{},extraClass:"",html:!1,sanitize:!0,sanitizeFn:null,template:"
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")),e}_typeCheckConfig(t){super._typeCheckConfig(t),this._checkContent(t.content)}_checkContent(t){for(const[e,i]of Object.entries(t))super._typeCheckConfig({selector:e,entry:i},Gn)}_setContent(t,e,i){const n=z.findOne(i,t);n&&((e=this._resolvePossibleFunction(e))?o(e)?this._putElementInTemplate(r(e),n):this._config.html?n.innerHTML=this._maybeSanitize(e):n.textContent=e:n.remove())}_maybeSanitize(t){return this._config.sanitize?function(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(const t of s){const i=t.nodeName.toLowerCase();if(!Object.keys(e).includes(i)){t.remove();continue}const n=[].concat(...t.attributes),s=[].concat(e["*"]||[],e[i]||[]);for(const e of n)Xn(e,s)||t.removeAttribute(e.nodeName)}return n.body.innerHTML}(t,this._config.allowList,this._config.sanitizeFn):t}_resolvePossibleFunction(t){return g(t,[this])}_putElementInTemplate(t,e){if(this._config.html)return e.innerHTML="",void e.append(t);e.textContent=t.textContent}}const Zn=new Set(["sanitize","allowList","sanitizeFn"]),ts="fade",es="show",is=".modal",ns="hide.bs.modal",ss="hover",os="focus",rs={AUTO:"auto",TOP:"top",RIGHT:p()?"left":"right",BOTTOM:"bottom",LEFT:p()?"right":"left"},as={allowList:Vn,animation:!0,boundary:"clippingParents",container:!1,customClass:"",delay:0,fallbackPlacements:["top","right","bottom","left"],html:!1,offset:[0,6],placement:"top",popperConfig:null,sanitize:!0,sanitizeFn:null,selector:!1,template:'',title:"",trigger:"hover focus"},ls={allowList:"object",animation:"boolean",boundary:"(string|element)",container:"(string|element|boolean)",customClass:"(string|function)",delay:"(number|object)",fallbackPlacements:"array",html:"boolean",offset:"(array|string|function)",placement:"(string|function)",popperConfig:"(null|object|function)",sanitize:"boolean",sanitizeFn:"(null|function)",selector:"(string|boolean)",template:"string",title:"(string|element|function)",trigger:"string"};class cs extends W{constructor(t,e){if(void 0===vi)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t,e),this._isEnabled=!0,this._timeout=0,this._isHovered=null,this._activeTrigger={},this._popper=null,this._templateFactory=null,this._newContent=null,this.tip=null,this._setListeners(),this._config.selector||this._fixTitle()}static get Default(){return as}static get DefaultType(){return ls}static get NAME(){return"tooltip"}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(){this._isEnabled&&(this._activeTrigger.click=!this._activeTrigger.click,this._isShown()?this._leave():this._enter())}dispose(){clearTimeout(this._timeout),N.off(this._element.closest(is),ns,this._hideModalHandler),this._element.getAttribute("data-bs-original-title")&&this._element.setAttribute("title",this._element.getAttribute("data-bs-original-title")),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this._isWithContent()||!this._isEnabled)return;const t=N.trigger(this._element,this.constructor.eventName("show")),e=(c(this._element)||this._element.ownerDocument.documentElement).contains(this._element);if(t.defaultPrevented||!e)return;this._disposePopper();const i=this._getTipElement();this._element.setAttribute("aria-describedby",i.getAttribute("id"));const{container:n}=this._config;if(this._element.ownerDocument.documentElement.contains(this.tip)||(n.append(i),N.trigger(this._element,this.constructor.eventName("inserted"))),this._popper=this._createPopper(i),i.classList.add(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._queueCallback((()=>{N.trigger(this._element,this.constructor.eventName("shown")),!1===this._isHovered&&this._leave(),this._isHovered=!1}),this.tip,this._isAnimated())}hide(){if(this._isShown()&&!N.trigger(this._element,this.constructor.eventName("hide")).defaultPrevented){if(this._getTipElement().classList.remove(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._activeTrigger.click=!1,this._activeTrigger[os]=!1,this._activeTrigger[ss]=!1,this._isHovered=null,this._queueCallback((()=>{this._isWithActiveTrigger()||(this._isHovered||this._disposePopper(),this._element.removeAttribute("aria-describedby"),N.trigger(this._element,this.constructor.eventName("hidden")))}),this.tip,this._isAnimated())}}update(){this._popper&&this._popper.update()}_isWithContent(){return Boolean(this._getTitle())}_getTipElement(){return this.tip||(this.tip=this._createTipElement(this._newContent||this._getContentForTemplate())),this.tip}_createTipElement(t){const e=this._getTemplateFactory(t).toHtml();if(!e)return null;e.classList.remove(ts,es),e.classList.add(`bs-${this.constructor.NAME}-auto`);const i=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME).toString();return e.setAttribute("id",i),this._isAnimated()&&e.classList.add(ts),e}setContent(t){this._newContent=t,this._isShown()&&(this._disposePopper(),this.show())}_getTemplateFactory(t){return this._templateFactory?this._templateFactory.changeContent(t):this._templateFactory=new Jn({...this._config,content:t,extraClass:this._resolvePossibleFunction(this._config.customClass)}),this._templateFactory}_getContentForTemplate(){return{".tooltip-inner":this._getTitle()}}_getTitle(){return this._resolvePossibleFunction(this._config.title)||this._element.getAttribute("data-bs-original-title")}_initializeOnDelegatedTarget(t){return this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_isAnimated(){return this._config.animation||this.tip&&this.tip.classList.contains(ts)}_isShown(){return this.tip&&this.tip.classList.contains(es)}_createPopper(t){const e=g(this._config.placement,[this,t,this._element]),i=rs[e.toUpperCase()];return bi(this._element,t,this._getPopperConfig(i))}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_resolvePossibleFunction(t){return g(t,[this._element])}_getPopperConfig(t){const e={placement:t,modifiers:[{name:"flip",options:{fallbackPlacements:this._config.fallbackPlacements}},{name:"offset",options:{offset:this._getOffset()}},{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"arrow",options:{element:`.${this.constructor.NAME}-arrow`}},{name:"preSetPlacement",enabled:!0,phase:"beforeMain",fn:t=>{this._getTipElement().setAttribute("data-popper-placement",t.state.placement)}}]};return{...e,...g(this._config.popperConfig,[e])}}_setListeners(){const t=this._config.trigger.split(" ");for(const e of t)if("click"===e)N.on(this._element,this.constructor.eventName("click"),this._config.selector,(t=>{this._initializeOnDelegatedTarget(t).toggle()}));else 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object[0] : object\n }\n\n if (typeof object === 'string' && object.length > 0) {\n return document.querySelector(parseSelector(object))\n }\n\n return null\n}\n\nconst isVisible = element => {\n if (!isElement(element) || element.getClientRects().length === 0) {\n return false\n }\n\n const elementIsVisible = getComputedStyle(element).getPropertyValue('visibility') === 'visible'\n // Handle `details` element as its content may falsie appear visible when it is closed\n const closedDetails = element.closest('details:not([open])')\n\n if (!closedDetails) {\n return elementIsVisible\n }\n\n if (closedDetails !== element) {\n const summary = element.closest('summary')\n if (summary && summary.parentNode !== closedDetails) {\n return false\n }\n\n if (summary === null) {\n return false\n }\n }\n\n return elementIsVisible\n}\n\nconst isDisabled = element => {\n if (!element || element.nodeType !== Node.ELEMENT_NODE) {\n return true\n }\n\n if (element.classList.contains('disabled')) {\n return true\n }\n\n if (typeof element.disabled !== 'undefined') {\n return element.disabled\n }\n\n return element.hasAttribute('disabled') && element.getAttribute('disabled') !== 'false'\n}\n\nconst findShadowRoot = element => {\n if (!document.documentElement.attachShadow) {\n return null\n }\n\n // Can find the shadow root otherwise it'll return the document\n if (typeof element.getRootNode === 'function') {\n const root = element.getRootNode()\n return root instanceof ShadowRoot ? root : null\n }\n\n if (element instanceof ShadowRoot) {\n return element\n }\n\n // when we don't find a shadow root\n if (!element.parentNode) {\n return null\n }\n\n return findShadowRoot(element.parentNode)\n}\n\nconst noop = () => {}\n\n/**\n * Trick to restart an element's animation\n *\n * @param {HTMLElement} element\n * @return void\n *\n * @see https://www.charistheo.io/blog/2021/02/restart-a-css-animation-with-javascript/#restarting-a-css-animation\n */\nconst reflow = element => {\n element.offsetHeight // eslint-disable-line no-unused-expressions\n}\n\nconst getjQuery = () => {\n if (window.jQuery && !document.body.hasAttribute('data-bs-no-jquery')) {\n return window.jQuery\n }\n\n return null\n}\n\nconst DOMContentLoadedCallbacks = []\n\nconst onDOMContentLoaded = callback => {\n if (document.readyState === 'loading') {\n // add listener on the first call when the document is in loading state\n if (!DOMContentLoadedCallbacks.length) {\n document.addEventListener('DOMContentLoaded', () => {\n for (const callback of DOMContentLoadedCallbacks) {\n callback()\n }\n })\n }\n\n DOMContentLoadedCallbacks.push(callback)\n } else {\n callback()\n }\n}\n\nconst isRTL = () => document.documentElement.dir === 'rtl'\n\nconst defineJQueryPlugin = plugin => {\n onDOMContentLoaded(() => {\n const $ = getjQuery()\n /* istanbul ignore if */\n if ($) {\n const name = plugin.NAME\n const JQUERY_NO_CONFLICT = $.fn[name]\n $.fn[name] = plugin.jQueryInterface\n $.fn[name].Constructor = plugin\n $.fn[name].noConflict = () => {\n $.fn[name] = JQUERY_NO_CONFLICT\n return plugin.jQueryInterface\n }\n }\n })\n}\n\nconst execute = (possibleCallback, args = [], defaultValue = possibleCallback) => {\n return typeof possibleCallback === 'function' ? possibleCallback(...args) : defaultValue\n}\n\nconst executeAfterTransition = (callback, transitionElement, waitForTransition = true) => {\n if (!waitForTransition) {\n execute(callback)\n return\n }\n\n const durationPadding = 5\n const emulatedDuration = getTransitionDurationFromElement(transitionElement) + durationPadding\n\n let called = false\n\n const handler = ({ target }) => {\n if (target !== transitionElement) {\n return\n }\n\n called = true\n transitionElement.removeEventListener(TRANSITION_END, handler)\n execute(callback)\n }\n\n transitionElement.addEventListener(TRANSITION_END, handler)\n setTimeout(() => {\n if (!called) {\n triggerTransitionEnd(transitionElement)\n }\n }, emulatedDuration)\n}\n\n/**\n * Return the previous/next element of a list.\n *\n * @param {array} list The list of elements\n * @param activeElement The active element\n * @param shouldGetNext Choose to get next or previous element\n * @param isCycleAllowed\n * @return {Element|elem} The proper element\n */\nconst getNextActiveElement = (list, activeElement, shouldGetNext, isCycleAllowed) => {\n const listLength = list.length\n let index = list.indexOf(activeElement)\n\n // if the element does not exist in the list return an element\n // depending on the direction and if cycle is allowed\n if (index === -1) {\n return !shouldGetNext && isCycleAllowed ? list[listLength - 1] : list[0]\n }\n\n index += shouldGetNext ? 1 : -1\n\n if (isCycleAllowed) {\n index = (index + listLength) % listLength\n }\n\n return list[Math.max(0, Math.min(index, listLength - 1))]\n}\n\nexport {\n defineJQueryPlugin,\n execute,\n executeAfterTransition,\n findShadowRoot,\n getElement,\n getjQuery,\n getNextActiveElement,\n getTransitionDurationFromElement,\n getUID,\n isDisabled,\n isElement,\n isRTL,\n isVisible,\n noop,\n onDOMContentLoaded,\n parseSelector,\n reflow,\n triggerTransitionEnd,\n toType\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/event-handler.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { getjQuery } from '../util/index.js'\n\n/**\n * Constants\n */\n\nconst namespaceRegex = /[^.]*(?=\\..*)\\.|.*/\nconst stripNameRegex = /\\..*/\nconst stripUidRegex = /::\\d+$/\nconst eventRegistry = {} // Events storage\nlet uidEvent = 1\nconst customEvents = {\n mouseenter: 'mouseover',\n mouseleave: 'mouseout'\n}\n\nconst nativeEvents = new Set([\n 'click',\n 'dblclick',\n 'mouseup',\n 'mousedown',\n 'contextmenu',\n 'mousewheel',\n 'DOMMouseScroll',\n 'mouseover',\n 'mouseout',\n 'mousemove',\n 'selectstart',\n 'selectend',\n 'keydown',\n 'keypress',\n 'keyup',\n 'orientationchange',\n 'touchstart',\n 'touchmove',\n 'touchend',\n 'touchcancel',\n 'pointerdown',\n 'pointermove',\n 'pointerup',\n 'pointerleave',\n 'pointercancel',\n 'gesturestart',\n 'gesturechange',\n 'gestureend',\n 'focus',\n 'blur',\n 'change',\n 'reset',\n 'select',\n 'submit',\n 'focusin',\n 'focusout',\n 'load',\n 'unload',\n 'beforeunload',\n 'resize',\n 'move',\n 'DOMContentLoaded',\n 'readystatechange',\n 'error',\n 'abort',\n 'scroll'\n])\n\n/**\n * Private methods\n */\n\nfunction makeEventUid(element, uid) {\n return (uid && `${uid}::${uidEvent++}`) || element.uidEvent || uidEvent++\n}\n\nfunction getElementEvents(element) {\n const uid = makeEventUid(element)\n\n element.uidEvent = uid\n eventRegistry[uid] = eventRegistry[uid] || {}\n\n return eventRegistry[uid]\n}\n\nfunction bootstrapHandler(element, fn) {\n return function handler(event) {\n hydrateObj(event, { delegateTarget: element })\n\n if (handler.oneOff) {\n EventHandler.off(element, event.type, fn)\n }\n\n return fn.apply(element, [event])\n }\n}\n\nfunction bootstrapDelegationHandler(element, selector, fn) {\n return function handler(event) {\n const domElements = element.querySelectorAll(selector)\n\n for (let { target } = event; target && target !== this; target = target.parentNode) {\n for (const domElement of domElements) {\n if (domElement !== target) {\n continue\n }\n\n hydrateObj(event, { delegateTarget: target })\n\n if (handler.oneOff) {\n EventHandler.off(element, event.type, selector, fn)\n }\n\n return fn.apply(target, [event])\n }\n }\n }\n}\n\nfunction findHandler(events, callable, delegationSelector = null) {\n return Object.values(events)\n .find(event => event.callable === callable && event.delegationSelector === delegationSelector)\n}\n\nfunction normalizeParameters(originalTypeEvent, handler, delegationFunction) {\n const isDelegated = typeof handler === 'string'\n // TODO: tooltip passes `false` instead of selector, so we need to check\n const callable = isDelegated ? delegationFunction : (handler || delegationFunction)\n let typeEvent = getTypeEvent(originalTypeEvent)\n\n if (!nativeEvents.has(typeEvent)) {\n typeEvent = originalTypeEvent\n }\n\n return [isDelegated, callable, typeEvent]\n}\n\nfunction addHandler(element, originalTypeEvent, handler, delegationFunction, oneOff) {\n if (typeof originalTypeEvent !== 'string' || !element) {\n return\n }\n\n let [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n\n // in case of mouseenter or mouseleave wrap the handler within a function that checks for its DOM position\n // this prevents the handler from being dispatched the same way as mouseover or mouseout does\n if (originalTypeEvent in customEvents) {\n const wrapFunction = fn => {\n return function (event) {\n if (!event.relatedTarget || (event.relatedTarget !== event.delegateTarget && !event.delegateTarget.contains(event.relatedTarget))) {\n return fn.call(this, event)\n }\n }\n }\n\n callable = wrapFunction(callable)\n }\n\n const events = getElementEvents(element)\n const handlers = events[typeEvent] || (events[typeEvent] = {})\n const previousFunction = findHandler(handlers, callable, isDelegated ? handler : null)\n\n if (previousFunction) {\n previousFunction.oneOff = previousFunction.oneOff && oneOff\n\n return\n }\n\n const uid = makeEventUid(callable, originalTypeEvent.replace(namespaceRegex, ''))\n const fn = isDelegated ?\n bootstrapDelegationHandler(element, handler, callable) :\n bootstrapHandler(element, callable)\n\n fn.delegationSelector = isDelegated ? handler : null\n fn.callable = callable\n fn.oneOff = oneOff\n fn.uidEvent = uid\n handlers[uid] = fn\n\n element.addEventListener(typeEvent, fn, isDelegated)\n}\n\nfunction removeHandler(element, events, typeEvent, handler, delegationSelector) {\n const fn = findHandler(events[typeEvent], handler, delegationSelector)\n\n if (!fn) {\n return\n }\n\n element.removeEventListener(typeEvent, fn, Boolean(delegationSelector))\n delete events[typeEvent][fn.uidEvent]\n}\n\nfunction removeNamespacedHandlers(element, events, typeEvent, namespace) {\n const storeElementEvent = events[typeEvent] || {}\n\n for (const [handlerKey, event] of Object.entries(storeElementEvent)) {\n if (handlerKey.includes(namespace)) {\n removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n }\n }\n}\n\nfunction getTypeEvent(event) {\n // allow to get the native events from namespaced events ('click.bs.button' --> 'click')\n event = event.replace(stripNameRegex, '')\n return customEvents[event] || event\n}\n\nconst EventHandler = {\n on(element, event, handler, delegationFunction) {\n addHandler(element, event, handler, delegationFunction, false)\n },\n\n one(element, event, handler, delegationFunction) {\n addHandler(element, event, handler, delegationFunction, true)\n },\n\n off(element, originalTypeEvent, handler, delegationFunction) {\n if (typeof originalTypeEvent !== 'string' || !element) {\n return\n }\n\n const [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n const inNamespace = typeEvent !== originalTypeEvent\n const events = getElementEvents(element)\n const storeElementEvent = events[typeEvent] || {}\n const isNamespace = originalTypeEvent.startsWith('.')\n\n if (typeof callable !== 'undefined') {\n // Simplest case: handler is passed, remove that listener ONLY.\n if (!Object.keys(storeElementEvent).length) {\n return\n }\n\n removeHandler(element, events, typeEvent, callable, isDelegated ? handler : null)\n return\n }\n\n if (isNamespace) {\n for (const elementEvent of Object.keys(events)) {\n removeNamespacedHandlers(element, events, elementEvent, originalTypeEvent.slice(1))\n }\n }\n\n for (const [keyHandlers, event] of Object.entries(storeElementEvent)) {\n const handlerKey = keyHandlers.replace(stripUidRegex, '')\n\n if (!inNamespace || originalTypeEvent.includes(handlerKey)) {\n removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n }\n }\n },\n\n trigger(element, event, args) {\n if (typeof event !== 'string' || !element) {\n return null\n }\n\n const $ = getjQuery()\n const typeEvent = getTypeEvent(event)\n const inNamespace = event !== typeEvent\n\n let jQueryEvent = null\n let bubbles = true\n let nativeDispatch = true\n let defaultPrevented = false\n\n if (inNamespace && $) {\n jQueryEvent = $.Event(event, args)\n\n $(element).trigger(jQueryEvent)\n bubbles = !jQueryEvent.isPropagationStopped()\n nativeDispatch = !jQueryEvent.isImmediatePropagationStopped()\n defaultPrevented = jQueryEvent.isDefaultPrevented()\n }\n\n const evt = hydrateObj(new Event(event, { bubbles, cancelable: true }), args)\n\n if (defaultPrevented) {\n evt.preventDefault()\n }\n\n if (nativeDispatch) {\n element.dispatchEvent(evt)\n }\n\n if (evt.defaultPrevented && jQueryEvent) {\n jQueryEvent.preventDefault()\n }\n\n return evt\n }\n}\n\nfunction hydrateObj(obj, meta = {}) {\n for (const [key, value] of Object.entries(meta)) {\n try {\n obj[key] = value\n } catch {\n Object.defineProperty(obj, key, {\n configurable: true,\n get() {\n return value\n }\n })\n }\n }\n\n return obj\n}\n\nexport default EventHandler\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/manipulator.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nfunction normalizeData(value) {\n if (value === 'true') {\n return true\n }\n\n if (value === 'false') {\n return false\n }\n\n if (value === Number(value).toString()) {\n return Number(value)\n }\n\n if (value === '' || value === 'null') {\n return null\n }\n\n if (typeof value !== 'string') {\n return value\n }\n\n try {\n return JSON.parse(decodeURIComponent(value))\n } catch {\n return value\n }\n}\n\nfunction normalizeDataKey(key) {\n return key.replace(/[A-Z]/g, chr => `-${chr.toLowerCase()}`)\n}\n\nconst Manipulator = {\n setDataAttribute(element, key, value) {\n element.setAttribute(`data-bs-${normalizeDataKey(key)}`, value)\n },\n\n removeDataAttribute(element, key) {\n element.removeAttribute(`data-bs-${normalizeDataKey(key)}`)\n },\n\n getDataAttributes(element) {\n if (!element) {\n return {}\n }\n\n const attributes = {}\n const bsKeys = Object.keys(element.dataset).filter(key => key.startsWith('bs') && !key.startsWith('bsConfig'))\n\n for (const key of bsKeys) {\n let pureKey = key.replace(/^bs/, '')\n pureKey = pureKey.charAt(0).toLowerCase() + pureKey.slice(1, pureKey.length)\n attributes[pureKey] = normalizeData(element.dataset[key])\n }\n\n return attributes\n },\n\n getDataAttribute(element, key) {\n return normalizeData(element.getAttribute(`data-bs-${normalizeDataKey(key)}`))\n }\n}\n\nexport default Manipulator\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/config.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Manipulator from '../dom/manipulator.js'\nimport { isElement, toType } from './index.js'\n\n/**\n * Class definition\n */\n\nclass Config {\n // Getters\n static get Default() {\n return {}\n }\n\n static get DefaultType() {\n return {}\n }\n\n static get NAME() {\n throw new Error('You have to implement the static method \"NAME\", for each component!')\n }\n\n _getConfig(config) {\n config = this._mergeConfigObj(config)\n config = this._configAfterMerge(config)\n this._typeCheckConfig(config)\n return config\n }\n\n _configAfterMerge(config) {\n return config\n }\n\n _mergeConfigObj(config, element) {\n const jsonConfig = isElement(element) ? Manipulator.getDataAttribute(element, 'config') : {} // try to parse\n\n return {\n ...this.constructor.Default,\n ...(typeof jsonConfig === 'object' ? jsonConfig : {}),\n ...(isElement(element) ? Manipulator.getDataAttributes(element) : {}),\n ...(typeof config === 'object' ? config : {})\n }\n }\n\n _typeCheckConfig(config, configTypes = this.constructor.DefaultType) {\n for (const [property, expectedTypes] of Object.entries(configTypes)) {\n const value = config[property]\n const valueType = isElement(value) ? 'element' : toType(value)\n\n if (!new RegExp(expectedTypes).test(valueType)) {\n throw new TypeError(\n `${this.constructor.NAME.toUpperCase()}: Option \"${property}\" provided type \"${valueType}\" but expected type \"${expectedTypes}\".`\n )\n }\n }\n }\n}\n\nexport default Config\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap base-component.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Data from './dom/data.js'\nimport EventHandler from './dom/event-handler.js'\nimport Config from './util/config.js'\nimport { executeAfterTransition, getElement } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst VERSION = '5.3.1'\n\n/**\n * Class definition\n */\n\nclass BaseComponent extends Config {\n constructor(element, config) {\n super()\n\n element = getElement(element)\n if (!element) {\n return\n }\n\n this._element = element\n this._config = this._getConfig(config)\n\n Data.set(this._element, this.constructor.DATA_KEY, this)\n }\n\n // Public\n dispose() {\n Data.remove(this._element, this.constructor.DATA_KEY)\n EventHandler.off(this._element, this.constructor.EVENT_KEY)\n\n for (const propertyName of Object.getOwnPropertyNames(this)) {\n this[propertyName] = null\n }\n }\n\n _queueCallback(callback, element, isAnimated = true) {\n executeAfterTransition(callback, element, isAnimated)\n }\n\n _getConfig(config) {\n config = this._mergeConfigObj(config, this._element)\n config = this._configAfterMerge(config)\n this._typeCheckConfig(config)\n return config\n }\n\n // Static\n static getInstance(element) {\n return Data.get(getElement(element), this.DATA_KEY)\n }\n\n static getOrCreateInstance(element, config = {}) {\n return this.getInstance(element) || new this(element, typeof config === 'object' ? config : null)\n }\n\n static get VERSION() {\n return VERSION\n }\n\n static get DATA_KEY() {\n return `bs.${this.NAME}`\n }\n\n static get EVENT_KEY() {\n return `.${this.DATA_KEY}`\n }\n\n static eventName(name) {\n return `${name}${this.EVENT_KEY}`\n }\n}\n\nexport default BaseComponent\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/selector-engine.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { isDisabled, isVisible, parseSelector } from '../util/index.js'\n\nconst getSelector = element => {\n let selector = element.getAttribute('data-bs-target')\n\n if (!selector || selector === '#') {\n let hrefAttribute = element.getAttribute('href')\n\n // The only valid content that could double as a selector are IDs or classes,\n // so everything starting with `#` or `.`. If a \"real\" URL is used as the selector,\n // `document.querySelector` will rightfully complain it is invalid.\n // See https://github.com/twbs/bootstrap/issues/32273\n if (!hrefAttribute || (!hrefAttribute.includes('#') && !hrefAttribute.startsWith('.'))) {\n return null\n }\n\n // Just in case some CMS puts out a full URL with the anchor appended\n if (hrefAttribute.includes('#') && !hrefAttribute.startsWith('#')) {\n hrefAttribute = `#${hrefAttribute.split('#')[1]}`\n }\n\n selector = hrefAttribute && hrefAttribute !== '#' ? hrefAttribute.trim() : null\n }\n\n return parseSelector(selector)\n}\n\nconst SelectorEngine = {\n find(selector, element = document.documentElement) {\n return [].concat(...Element.prototype.querySelectorAll.call(element, selector))\n },\n\n findOne(selector, element = document.documentElement) {\n return Element.prototype.querySelector.call(element, selector)\n },\n\n children(element, selector) {\n return [].concat(...element.children).filter(child => child.matches(selector))\n },\n\n parents(element, selector) {\n const parents = []\n let ancestor = element.parentNode.closest(selector)\n\n while (ancestor) {\n parents.push(ancestor)\n ancestor = ancestor.parentNode.closest(selector)\n }\n\n return parents\n },\n\n prev(element, selector) {\n let previous = element.previousElementSibling\n\n while (previous) {\n if (previous.matches(selector)) {\n return [previous]\n }\n\n previous = previous.previousElementSibling\n }\n\n return []\n },\n // TODO: this is now unused; remove later along with prev()\n next(element, selector) {\n let next = element.nextElementSibling\n\n while (next) {\n if (next.matches(selector)) {\n return [next]\n }\n\n next = next.nextElementSibling\n }\n\n return []\n },\n\n focusableChildren(element) {\n const focusables = [\n 'a',\n 'button',\n 'input',\n 'textarea',\n 'select',\n 'details',\n '[tabindex]',\n '[contenteditable=\"true\"]'\n ].map(selector => `${selector}:not([tabindex^=\"-\"])`).join(',')\n\n return this.find(focusables, element).filter(el => !isDisabled(el) && isVisible(el))\n },\n\n getSelectorFromElement(element) {\n const selector = getSelector(element)\n\n if (selector) {\n return SelectorEngine.findOne(selector) ? selector : null\n }\n\n return null\n },\n\n getElementFromSelector(element) {\n const selector = getSelector(element)\n\n return selector ? SelectorEngine.findOne(selector) : null\n },\n\n getMultipleElementsFromSelector(element) {\n const selector = getSelector(element)\n\n return selector ? SelectorEngine.find(selector) : []\n }\n}\n\nexport default SelectorEngine\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/component-functions.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport { isDisabled } from './index.js'\n\nconst enableDismissTrigger = (component, method = 'hide') => {\n const clickEvent = `click.dismiss${component.EVENT_KEY}`\n const name = component.NAME\n\n EventHandler.on(document, clickEvent, `[data-bs-dismiss=\"${name}\"]`, function (event) {\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n if (isDisabled(this)) {\n return\n }\n\n const target = SelectorEngine.getElementFromSelector(this) || this.closest(`.${name}`)\n const instance = component.getOrCreateInstance(target)\n\n // Method argument is left, for Alert and only, as it doesn't implement the 'hide' method\n instance[method]()\n })\n}\n\nexport {\n enableDismissTrigger\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap alert.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'alert'\nconst DATA_KEY = 'bs.alert'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_CLOSE = `close${EVENT_KEY}`\nconst EVENT_CLOSED = `closed${EVENT_KEY}`\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\n/**\n * Class definition\n */\n\nclass Alert extends BaseComponent {\n // Getters\n static get NAME() {\n return NAME\n }\n\n // Public\n close() {\n const closeEvent = EventHandler.trigger(this._element, EVENT_CLOSE)\n\n if (closeEvent.defaultPrevented) {\n return\n }\n\n this._element.classList.remove(CLASS_NAME_SHOW)\n\n const isAnimated = this._element.classList.contains(CLASS_NAME_FADE)\n this._queueCallback(() => this._destroyElement(), this._element, isAnimated)\n }\n\n // Private\n _destroyElement() {\n this._element.remove()\n EventHandler.trigger(this._element, EVENT_CLOSED)\n this.dispose()\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Alert.getOrCreateInstance(this)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](this)\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nenableDismissTrigger(Alert, 'close')\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Alert)\n\nexport default Alert\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap button.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'button'\nconst DATA_KEY = 'bs.button'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst CLASS_NAME_ACTIVE = 'active'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"button\"]'\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\n/**\n * Class definition\n */\n\nclass Button extends BaseComponent {\n // Getters\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle() {\n // Toggle class and sync the `aria-pressed` attribute with the return value of the `.toggle()` method\n this._element.setAttribute('aria-pressed', this._element.classList.toggle(CLASS_NAME_ACTIVE))\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Button.getOrCreateInstance(this)\n\n if (config === 'toggle') {\n data[config]()\n }\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, event => {\n event.preventDefault()\n\n const button = event.target.closest(SELECTOR_DATA_TOGGLE)\n const data = Button.getOrCreateInstance(button)\n\n data.toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Button)\n\nexport default Button\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/swipe.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport Config from './config.js'\nimport { execute } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'swipe'\nconst EVENT_KEY = '.bs.swipe'\nconst EVENT_TOUCHSTART = `touchstart${EVENT_KEY}`\nconst EVENT_TOUCHMOVE = `touchmove${EVENT_KEY}`\nconst EVENT_TOUCHEND = `touchend${EVENT_KEY}`\nconst EVENT_POINTERDOWN = `pointerdown${EVENT_KEY}`\nconst EVENT_POINTERUP = `pointerup${EVENT_KEY}`\nconst POINTER_TYPE_TOUCH = 'touch'\nconst POINTER_TYPE_PEN = 'pen'\nconst CLASS_NAME_POINTER_EVENT = 'pointer-event'\nconst SWIPE_THRESHOLD = 40\n\nconst Default = {\n endCallback: null,\n leftCallback: null,\n rightCallback: null\n}\n\nconst DefaultType = {\n endCallback: '(function|null)',\n leftCallback: '(function|null)',\n rightCallback: '(function|null)'\n}\n\n/**\n * Class definition\n */\n\nclass Swipe extends Config {\n constructor(element, config) {\n super()\n this._element = element\n\n if (!element || !Swipe.isSupported()) {\n return\n }\n\n this._config = this._getConfig(config)\n this._deltaX = 0\n this._supportPointerEvents = Boolean(window.PointerEvent)\n this._initEvents()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n dispose() {\n EventHandler.off(this._element, EVENT_KEY)\n }\n\n // Private\n _start(event) {\n if (!this._supportPointerEvents) {\n this._deltaX = event.touches[0].clientX\n\n return\n }\n\n if (this._eventIsPointerPenTouch(event)) {\n this._deltaX = event.clientX\n }\n }\n\n _end(event) {\n if (this._eventIsPointerPenTouch(event)) {\n this._deltaX = event.clientX - this._deltaX\n }\n\n this._handleSwipe()\n execute(this._config.endCallback)\n }\n\n _move(event) {\n this._deltaX = event.touches && event.touches.length > 1 ?\n 0 :\n event.touches[0].clientX - this._deltaX\n }\n\n _handleSwipe() {\n const absDeltaX = Math.abs(this._deltaX)\n\n if (absDeltaX <= SWIPE_THRESHOLD) {\n return\n }\n\n const direction = absDeltaX / this._deltaX\n\n this._deltaX = 0\n\n if (!direction) {\n return\n }\n\n execute(direction > 0 ? this._config.rightCallback : this._config.leftCallback)\n }\n\n _initEvents() {\n if (this._supportPointerEvents) {\n EventHandler.on(this._element, EVENT_POINTERDOWN, event => this._start(event))\n EventHandler.on(this._element, EVENT_POINTERUP, event => this._end(event))\n\n this._element.classList.add(CLASS_NAME_POINTER_EVENT)\n } else {\n EventHandler.on(this._element, EVENT_TOUCHSTART, event => this._start(event))\n EventHandler.on(this._element, EVENT_TOUCHMOVE, event => this._move(event))\n EventHandler.on(this._element, EVENT_TOUCHEND, event => this._end(event))\n }\n }\n\n _eventIsPointerPenTouch(event) {\n return this._supportPointerEvents && (event.pointerType === POINTER_TYPE_PEN || event.pointerType === POINTER_TYPE_TOUCH)\n }\n\n // Static\n static isSupported() {\n return 'ontouchstart' in document.documentElement || navigator.maxTouchPoints > 0\n }\n}\n\nexport default Swipe\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap carousel.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n defineJQueryPlugin,\n getNextActiveElement,\n isRTL,\n isVisible,\n reflow,\n triggerTransitionEnd\n} from './util/index.js'\nimport Swipe from './util/swipe.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'carousel'\nconst DATA_KEY = 'bs.carousel'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst TOUCHEVENT_COMPAT_WAIT = 500 // Time for mouse compat events to fire after touch\n\nconst ORDER_NEXT = 'next'\nconst ORDER_PREV = 'prev'\nconst DIRECTION_LEFT = 'left'\nconst DIRECTION_RIGHT = 'right'\n\nconst EVENT_SLIDE = `slide${EVENT_KEY}`\nconst EVENT_SLID = `slid${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_MOUSEENTER = `mouseenter${EVENT_KEY}`\nconst EVENT_MOUSELEAVE = `mouseleave${EVENT_KEY}`\nconst EVENT_DRAG_START = `dragstart${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_CAROUSEL = 'carousel'\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_SLIDE = 'slide'\nconst CLASS_NAME_END = 'carousel-item-end'\nconst CLASS_NAME_START = 'carousel-item-start'\nconst CLASS_NAME_NEXT = 'carousel-item-next'\nconst CLASS_NAME_PREV = 'carousel-item-prev'\n\nconst SELECTOR_ACTIVE = '.active'\nconst SELECTOR_ITEM = '.carousel-item'\nconst SELECTOR_ACTIVE_ITEM = SELECTOR_ACTIVE + SELECTOR_ITEM\nconst SELECTOR_ITEM_IMG = '.carousel-item img'\nconst SELECTOR_INDICATORS = '.carousel-indicators'\nconst SELECTOR_DATA_SLIDE = '[data-bs-slide], [data-bs-slide-to]'\nconst SELECTOR_DATA_RIDE = '[data-bs-ride=\"carousel\"]'\n\nconst KEY_TO_DIRECTION = {\n [ARROW_LEFT_KEY]: DIRECTION_RIGHT,\n [ARROW_RIGHT_KEY]: DIRECTION_LEFT\n}\n\nconst Default = {\n interval: 5000,\n keyboard: true,\n pause: 'hover',\n ride: false,\n touch: true,\n wrap: true\n}\n\nconst DefaultType = {\n interval: '(number|boolean)', // TODO:v6 remove boolean support\n keyboard: 'boolean',\n pause: '(string|boolean)',\n ride: '(boolean|string)',\n touch: 'boolean',\n wrap: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Carousel extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._interval = null\n this._activeElement = null\n this._isSliding = false\n this.touchTimeout = null\n this._swipeHelper = null\n\n this._indicatorsElement = SelectorEngine.findOne(SELECTOR_INDICATORS, this._element)\n this._addEventListeners()\n\n if (this._config.ride === CLASS_NAME_CAROUSEL) {\n this.cycle()\n }\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n next() {\n this._slide(ORDER_NEXT)\n }\n\n nextWhenVisible() {\n // FIXME TODO use `document.visibilityState`\n // Don't call next when the page isn't visible\n // or the carousel or its parent isn't visible\n if (!document.hidden && isVisible(this._element)) {\n this.next()\n }\n }\n\n prev() {\n this._slide(ORDER_PREV)\n }\n\n pause() {\n if (this._isSliding) {\n triggerTransitionEnd(this._element)\n }\n\n this._clearInterval()\n }\n\n cycle() {\n this._clearInterval()\n this._updateInterval()\n\n this._interval = setInterval(() => this.nextWhenVisible(), this._config.interval)\n }\n\n _maybeEnableCycle() {\n if (!this._config.ride) {\n return\n }\n\n if (this._isSliding) {\n EventHandler.one(this._element, EVENT_SLID, () => this.cycle())\n return\n }\n\n this.cycle()\n }\n\n to(index) {\n const items = this._getItems()\n if (index > items.length - 1 || index < 0) {\n return\n }\n\n if (this._isSliding) {\n EventHandler.one(this._element, EVENT_SLID, () => this.to(index))\n return\n }\n\n const activeIndex = this._getItemIndex(this._getActive())\n if (activeIndex === index) {\n return\n }\n\n const order = index > activeIndex ? ORDER_NEXT : ORDER_PREV\n\n this._slide(order, items[index])\n }\n\n dispose() {\n if (this._swipeHelper) {\n this._swipeHelper.dispose()\n }\n\n super.dispose()\n }\n\n // Private\n _configAfterMerge(config) {\n config.defaultInterval = config.interval\n return config\n }\n\n _addEventListeners() {\n if (this._config.keyboard) {\n EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n }\n\n if (this._config.pause === 'hover') {\n EventHandler.on(this._element, EVENT_MOUSEENTER, () => this.pause())\n EventHandler.on(this._element, EVENT_MOUSELEAVE, () => this._maybeEnableCycle())\n }\n\n if (this._config.touch && Swipe.isSupported()) {\n this._addTouchEventListeners()\n }\n }\n\n _addTouchEventListeners() {\n for (const img of SelectorEngine.find(SELECTOR_ITEM_IMG, this._element)) {\n EventHandler.on(img, EVENT_DRAG_START, event => event.preventDefault())\n }\n\n const endCallBack = () => {\n if (this._config.pause !== 'hover') {\n return\n }\n\n // If it's a touch-enabled device, mouseenter/leave are fired as\n // part of the mouse compatibility events on first tap - the carousel\n // would stop cycling until user tapped out of it;\n // here, we listen for touchend, explicitly pause the carousel\n // (as if it's the second time we tap on it, mouseenter compat event\n // is NOT fired) and after a timeout (to allow for mouse compatibility\n // events to fire) we explicitly restart cycling\n\n this.pause()\n if (this.touchTimeout) {\n clearTimeout(this.touchTimeout)\n }\n\n this.touchTimeout = setTimeout(() => this._maybeEnableCycle(), TOUCHEVENT_COMPAT_WAIT + this._config.interval)\n }\n\n const swipeConfig = {\n leftCallback: () => this._slide(this._directionToOrder(DIRECTION_LEFT)),\n rightCallback: () => this._slide(this._directionToOrder(DIRECTION_RIGHT)),\n endCallback: endCallBack\n }\n\n this._swipeHelper = new Swipe(this._element, swipeConfig)\n }\n\n _keydown(event) {\n if (/input|textarea/i.test(event.target.tagName)) {\n return\n }\n\n const direction = KEY_TO_DIRECTION[event.key]\n if (direction) {\n event.preventDefault()\n this._slide(this._directionToOrder(direction))\n }\n }\n\n _getItemIndex(element) {\n return this._getItems().indexOf(element)\n }\n\n _setActiveIndicatorElement(index) {\n if (!this._indicatorsElement) {\n return\n }\n\n const activeIndicator = SelectorEngine.findOne(SELECTOR_ACTIVE, this._indicatorsElement)\n\n activeIndicator.classList.remove(CLASS_NAME_ACTIVE)\n activeIndicator.removeAttribute('aria-current')\n\n const newActiveIndicator = SelectorEngine.findOne(`[data-bs-slide-to=\"${index}\"]`, this._indicatorsElement)\n\n if (newActiveIndicator) {\n newActiveIndicator.classList.add(CLASS_NAME_ACTIVE)\n newActiveIndicator.setAttribute('aria-current', 'true')\n }\n }\n\n _updateInterval() {\n const element = this._activeElement || this._getActive()\n\n if (!element) {\n return\n }\n\n const elementInterval = Number.parseInt(element.getAttribute('data-bs-interval'), 10)\n\n this._config.interval = elementInterval || this._config.defaultInterval\n }\n\n _slide(order, element = null) {\n if (this._isSliding) {\n return\n }\n\n const activeElement = this._getActive()\n const isNext = order === ORDER_NEXT\n const nextElement = element || getNextActiveElement(this._getItems(), activeElement, isNext, this._config.wrap)\n\n if (nextElement === activeElement) {\n return\n }\n\n const nextElementIndex = this._getItemIndex(nextElement)\n\n const triggerEvent = eventName => {\n return EventHandler.trigger(this._element, eventName, {\n relatedTarget: nextElement,\n direction: this._orderToDirection(order),\n from: this._getItemIndex(activeElement),\n to: nextElementIndex\n })\n }\n\n const slideEvent = triggerEvent(EVENT_SLIDE)\n\n if (slideEvent.defaultPrevented) {\n return\n }\n\n if (!activeElement || !nextElement) {\n // Some weirdness is happening, so we bail\n // TODO: change tests that use empty divs to avoid this check\n return\n }\n\n const isCycling = Boolean(this._interval)\n this.pause()\n\n this._isSliding = true\n\n this._setActiveIndicatorElement(nextElementIndex)\n this._activeElement = nextElement\n\n const directionalClassName = isNext ? CLASS_NAME_START : CLASS_NAME_END\n const orderClassName = isNext ? CLASS_NAME_NEXT : CLASS_NAME_PREV\n\n nextElement.classList.add(orderClassName)\n\n reflow(nextElement)\n\n activeElement.classList.add(directionalClassName)\n nextElement.classList.add(directionalClassName)\n\n const completeCallBack = () => {\n nextElement.classList.remove(directionalClassName, orderClassName)\n nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n activeElement.classList.remove(CLASS_NAME_ACTIVE, orderClassName, directionalClassName)\n\n this._isSliding = false\n\n triggerEvent(EVENT_SLID)\n }\n\n this._queueCallback(completeCallBack, activeElement, this._isAnimated())\n\n if (isCycling) {\n this.cycle()\n }\n }\n\n _isAnimated() {\n return this._element.classList.contains(CLASS_NAME_SLIDE)\n }\n\n _getActive() {\n return SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n }\n\n _getItems() {\n return SelectorEngine.find(SELECTOR_ITEM, this._element)\n }\n\n _clearInterval() {\n if (this._interval) {\n clearInterval(this._interval)\n this._interval = null\n }\n }\n\n _directionToOrder(direction) {\n if (isRTL()) {\n return direction === DIRECTION_LEFT ? ORDER_PREV : ORDER_NEXT\n }\n\n return direction === DIRECTION_LEFT ? ORDER_NEXT : ORDER_PREV\n }\n\n _orderToDirection(order) {\n if (isRTL()) {\n return order === ORDER_PREV ? DIRECTION_LEFT : DIRECTION_RIGHT\n }\n\n return order === ORDER_PREV ? DIRECTION_RIGHT : DIRECTION_LEFT\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Carousel.getOrCreateInstance(this, config)\n\n if (typeof config === 'number') {\n data.to(config)\n return\n }\n\n if (typeof config === 'string') {\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n }\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_SLIDE, function (event) {\n const target = SelectorEngine.getElementFromSelector(this)\n\n if (!target || !target.classList.contains(CLASS_NAME_CAROUSEL)) {\n return\n }\n\n event.preventDefault()\n\n const carousel = Carousel.getOrCreateInstance(target)\n const slideIndex = this.getAttribute('data-bs-slide-to')\n\n if (slideIndex) {\n carousel.to(slideIndex)\n carousel._maybeEnableCycle()\n return\n }\n\n if (Manipulator.getDataAttribute(this, 'slide') === 'next') {\n carousel.next()\n carousel._maybeEnableCycle()\n return\n }\n\n carousel.prev()\n carousel._maybeEnableCycle()\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n const carousels = SelectorEngine.find(SELECTOR_DATA_RIDE)\n\n for (const carousel of carousels) {\n Carousel.getOrCreateInstance(carousel)\n }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Carousel)\n\nexport default Carousel\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap collapse.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n defineJQueryPlugin,\n getElement,\n reflow\n} from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'collapse'\nconst DATA_KEY = 'bs.collapse'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_COLLAPSE = 'collapse'\nconst CLASS_NAME_COLLAPSING = 'collapsing'\nconst CLASS_NAME_COLLAPSED = 'collapsed'\nconst CLASS_NAME_DEEPER_CHILDREN = `:scope .${CLASS_NAME_COLLAPSE} .${CLASS_NAME_COLLAPSE}`\nconst CLASS_NAME_HORIZONTAL = 'collapse-horizontal'\n\nconst WIDTH = 'width'\nconst HEIGHT = 'height'\n\nconst SELECTOR_ACTIVES = '.collapse.show, .collapse.collapsing'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"collapse\"]'\n\nconst Default = {\n parent: null,\n toggle: true\n}\n\nconst DefaultType = {\n parent: '(null|element)',\n toggle: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Collapse extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._isTransitioning = false\n this._triggerArray = []\n\n const toggleList = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n for (const elem of toggleList) {\n const selector = SelectorEngine.getSelectorFromElement(elem)\n const filterElement = SelectorEngine.find(selector)\n .filter(foundElement => foundElement === this._element)\n\n if (selector !== null && filterElement.length) {\n this._triggerArray.push(elem)\n }\n }\n\n this._initializeChildren()\n\n if (!this._config.parent) {\n this._addAriaAndCollapsedClass(this._triggerArray, this._isShown())\n }\n\n if (this._config.toggle) {\n this.toggle()\n }\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle() {\n if (this._isShown()) {\n this.hide()\n } else {\n this.show()\n }\n }\n\n show() {\n if (this._isTransitioning || this._isShown()) {\n return\n }\n\n let activeChildren = []\n\n // find active children\n if (this._config.parent) {\n activeChildren = this._getFirstLevelChildren(SELECTOR_ACTIVES)\n .filter(element => element !== this._element)\n .map(element => Collapse.getOrCreateInstance(element, { toggle: false }))\n }\n\n if (activeChildren.length && activeChildren[0]._isTransitioning) {\n return\n }\n\n const startEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n if (startEvent.defaultPrevented) {\n return\n }\n\n for (const activeInstance of activeChildren) {\n activeInstance.hide()\n }\n\n const dimension = this._getDimension()\n\n this._element.classList.remove(CLASS_NAME_COLLAPSE)\n this._element.classList.add(CLASS_NAME_COLLAPSING)\n\n this._element.style[dimension] = 0\n\n this._addAriaAndCollapsedClass(this._triggerArray, true)\n this._isTransitioning = true\n\n const complete = () => {\n this._isTransitioning = false\n\n this._element.classList.remove(CLASS_NAME_COLLAPSING)\n this._element.classList.add(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n this._element.style[dimension] = ''\n\n EventHandler.trigger(this._element, EVENT_SHOWN)\n }\n\n const capitalizedDimension = dimension[0].toUpperCase() + dimension.slice(1)\n const scrollSize = `scroll${capitalizedDimension}`\n\n this._queueCallback(complete, this._element, true)\n this._element.style[dimension] = `${this._element[scrollSize]}px`\n }\n\n hide() {\n if (this._isTransitioning || !this._isShown()) {\n return\n }\n\n const startEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n if (startEvent.defaultPrevented) {\n return\n }\n\n const dimension = this._getDimension()\n\n this._element.style[dimension] = `${this._element.getBoundingClientRect()[dimension]}px`\n\n reflow(this._element)\n\n this._element.classList.add(CLASS_NAME_COLLAPSING)\n this._element.classList.remove(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n for (const trigger of this._triggerArray) {\n const element = SelectorEngine.getElementFromSelector(trigger)\n\n if (element && !this._isShown(element)) {\n this._addAriaAndCollapsedClass([trigger], false)\n }\n }\n\n this._isTransitioning = true\n\n const complete = () => {\n this._isTransitioning = false\n this._element.classList.remove(CLASS_NAME_COLLAPSING)\n this._element.classList.add(CLASS_NAME_COLLAPSE)\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n }\n\n this._element.style[dimension] = ''\n\n this._queueCallback(complete, this._element, true)\n }\n\n _isShown(element = this._element) {\n return element.classList.contains(CLASS_NAME_SHOW)\n }\n\n // Private\n _configAfterMerge(config) {\n config.toggle = Boolean(config.toggle) // Coerce string values\n config.parent = getElement(config.parent)\n return config\n }\n\n _getDimension() {\n return this._element.classList.contains(CLASS_NAME_HORIZONTAL) ? WIDTH : HEIGHT\n }\n\n _initializeChildren() {\n if (!this._config.parent) {\n return\n }\n\n const children = this._getFirstLevelChildren(SELECTOR_DATA_TOGGLE)\n\n for (const element of children) {\n const selected = SelectorEngine.getElementFromSelector(element)\n\n if (selected) {\n this._addAriaAndCollapsedClass([element], this._isShown(selected))\n }\n }\n }\n\n _getFirstLevelChildren(selector) {\n const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n // remove children if greater depth\n return SelectorEngine.find(selector, this._config.parent).filter(element => !children.includes(element))\n }\n\n _addAriaAndCollapsedClass(triggerArray, isOpen) {\n if (!triggerArray.length) {\n return\n }\n\n for (const element of triggerArray) {\n element.classList.toggle(CLASS_NAME_COLLAPSED, !isOpen)\n element.setAttribute('aria-expanded', isOpen)\n }\n }\n\n // Static\n static jQueryInterface(config) {\n const _config = {}\n if (typeof config === 'string' && /show|hide/.test(config)) {\n _config.toggle = false\n }\n\n return this.each(function () {\n const data = Collapse.getOrCreateInstance(this, _config)\n\n if (typeof config === 'string') {\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n }\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n // preventDefault only for elements (which change the URL) not inside the collapsible element\n if (event.target.tagName === 'A' || (event.delegateTarget && event.delegateTarget.tagName === 'A')) {\n event.preventDefault()\n }\n\n for (const element of SelectorEngine.getMultipleElementsFromSelector(this)) {\n Collapse.getOrCreateInstance(element, { toggle: false }).toggle()\n }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Collapse)\n\nexport default Collapse\n","export var top = 'top';\nexport var bottom = 'bottom';\nexport var right = 'right';\nexport var left = 'left';\nexport var auto = 'auto';\nexport var basePlacements = [top, bottom, right, left];\nexport var start = 'start';\nexport var end = 'end';\nexport var clippingParents = 'clippingParents';\nexport var viewport = 'viewport';\nexport var popper = 'popper';\nexport var reference = 'reference';\nexport var variationPlacements = /*#__PURE__*/basePlacements.reduce(function (acc, placement) {\n return acc.concat([placement + \"-\" + start, placement + \"-\" + end]);\n}, []);\nexport var placements = /*#__PURE__*/[].concat(basePlacements, [auto]).reduce(function (acc, placement) {\n return acc.concat([placement, placement + \"-\" + start, placement + \"-\" + end]);\n}, []); // modifiers that need to read the DOM\n\nexport var beforeRead = 'beforeRead';\nexport var read = 'read';\nexport var afterRead = 'afterRead'; // pure-logic modifiers\n\nexport var beforeMain = 'beforeMain';\nexport var main = 'main';\nexport var afterMain = 'afterMain'; // modifier with the purpose to write to the DOM (or write into a framework state)\n\nexport var beforeWrite = 'beforeWrite';\nexport var write = 'write';\nexport var afterWrite = 'afterWrite';\nexport var modifierPhases = [beforeRead, read, afterRead, beforeMain, main, afterMain, beforeWrite, write, afterWrite];","export default function getNodeName(element) {\n return element ? (element.nodeName || '').toLowerCase() : null;\n}","export default function getWindow(node) {\n if (node == null) {\n return window;\n }\n\n if (node.toString() !== '[object Window]') {\n var ownerDocument = node.ownerDocument;\n return ownerDocument ? ownerDocument.defaultView || window : window;\n }\n\n return node;\n}","import getWindow from \"./getWindow.js\";\n\nfunction isElement(node) {\n var OwnElement = getWindow(node).Element;\n return node instanceof OwnElement || node instanceof Element;\n}\n\nfunction isHTMLElement(node) {\n var OwnElement = getWindow(node).HTMLElement;\n return node instanceof OwnElement || node instanceof HTMLElement;\n}\n\nfunction isShadowRoot(node) {\n // IE 11 has no ShadowRoot\n if (typeof ShadowRoot === 'undefined') {\n return false;\n }\n\n var OwnElement = getWindow(node).ShadowRoot;\n return node instanceof OwnElement || node instanceof ShadowRoot;\n}\n\nexport { isElement, isHTMLElement, isShadowRoot };","import getNodeName from \"../dom-utils/getNodeName.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // This modifier takes the styles prepared by the `computeStyles` modifier\n// and applies them to the HTMLElements such as popper and arrow\n\nfunction applyStyles(_ref) {\n var state = _ref.state;\n Object.keys(state.elements).forEach(function (name) {\n var style = state.styles[name] || {};\n var attributes = state.attributes[name] || {};\n var element = state.elements[name]; // arrow is optional + virtual elements\n\n if (!isHTMLElement(element) || !getNodeName(element)) {\n return;\n } // Flow doesn't support to extend this property, but it's the most\n // effective way to apply styles to an HTMLElement\n // $FlowFixMe[cannot-write]\n\n\n Object.assign(element.style, style);\n Object.keys(attributes).forEach(function (name) {\n var value = attributes[name];\n\n if (value === false) {\n element.removeAttribute(name);\n } else {\n element.setAttribute(name, value === true ? '' : value);\n }\n });\n });\n}\n\nfunction effect(_ref2) {\n var state = _ref2.state;\n var initialStyles = {\n popper: {\n position: state.options.strategy,\n left: '0',\n top: '0',\n margin: '0'\n },\n arrow: {\n position: 'absolute'\n },\n reference: {}\n };\n Object.assign(state.elements.popper.style, initialStyles.popper);\n state.styles = initialStyles;\n\n if (state.elements.arrow) {\n Object.assign(state.elements.arrow.style, initialStyles.arrow);\n }\n\n return function () {\n Object.keys(state.elements).forEach(function (name) {\n var element = state.elements[name];\n var attributes = state.attributes[name] || {};\n var styleProperties = Object.keys(state.styles.hasOwnProperty(name) ? state.styles[name] : initialStyles[name]); // Set all values to an empty string to unset them\n\n var style = styleProperties.reduce(function (style, property) {\n style[property] = '';\n return style;\n }, {}); // arrow is optional + virtual elements\n\n if (!isHTMLElement(element) || !getNodeName(element)) {\n return;\n }\n\n Object.assign(element.style, style);\n Object.keys(attributes).forEach(function (attribute) {\n element.removeAttribute(attribute);\n });\n });\n };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'applyStyles',\n enabled: true,\n phase: 'write',\n fn: applyStyles,\n effect: effect,\n requires: ['computeStyles']\n};","import { auto } from \"../enums.js\";\nexport default function getBasePlacement(placement) {\n return placement.split('-')[0];\n}","export var max = Math.max;\nexport var min = Math.min;\nexport var round = Math.round;","export default function getUAString() {\n var uaData = navigator.userAgentData;\n\n if (uaData != null && uaData.brands && Array.isArray(uaData.brands)) {\n return uaData.brands.map(function (item) {\n return item.brand + \"/\" + item.version;\n }).join(' ');\n }\n\n return navigator.userAgent;\n}","import getUAString from \"../utils/userAgent.js\";\nexport default function isLayoutViewport() {\n return !/^((?!chrome|android).)*safari/i.test(getUAString());\n}","import { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport { round } from \"../utils/math.js\";\nimport getWindow from \"./getWindow.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getBoundingClientRect(element, includeScale, isFixedStrategy) {\n if (includeScale === void 0) {\n includeScale = false;\n }\n\n if (isFixedStrategy === void 0) {\n isFixedStrategy = false;\n }\n\n var clientRect = element.getBoundingClientRect();\n var scaleX = 1;\n var scaleY = 1;\n\n if (includeScale && isHTMLElement(element)) {\n scaleX = element.offsetWidth > 0 ? round(clientRect.width) / element.offsetWidth || 1 : 1;\n scaleY = element.offsetHeight > 0 ? round(clientRect.height) / element.offsetHeight || 1 : 1;\n }\n\n var _ref = isElement(element) ? getWindow(element) : window,\n visualViewport = _ref.visualViewport;\n\n var addVisualOffsets = !isLayoutViewport() && isFixedStrategy;\n var x = (clientRect.left + (addVisualOffsets && visualViewport ? visualViewport.offsetLeft : 0)) / scaleX;\n var y = (clientRect.top + (addVisualOffsets && visualViewport ? visualViewport.offsetTop : 0)) / scaleY;\n var width = clientRect.width / scaleX;\n var height = clientRect.height / scaleY;\n return {\n width: width,\n height: height,\n top: y,\n right: x + width,\n bottom: y + height,\n left: x,\n x: x,\n y: y\n };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\"; // Returns the layout rect of an element relative to its offsetParent. Layout\n// means it doesn't take into account transforms.\n\nexport default function getLayoutRect(element) {\n var clientRect = getBoundingClientRect(element); // Use the clientRect sizes if it's not been transformed.\n // Fixes https://github.com/popperjs/popper-core/issues/1223\n\n var width = element.offsetWidth;\n var height = element.offsetHeight;\n\n if (Math.abs(clientRect.width - width) <= 1) {\n width = clientRect.width;\n }\n\n if (Math.abs(clientRect.height - height) <= 1) {\n height = clientRect.height;\n }\n\n return {\n x: element.offsetLeft,\n y: element.offsetTop,\n width: width,\n height: height\n };\n}","import { isShadowRoot } from \"./instanceOf.js\";\nexport default function contains(parent, child) {\n var rootNode = child.getRootNode && child.getRootNode(); // First, attempt with faster native method\n\n if (parent.contains(child)) {\n return true;\n } // then fallback to custom implementation with Shadow DOM support\n else if (rootNode && isShadowRoot(rootNode)) {\n var next = child;\n\n do {\n if (next && parent.isSameNode(next)) {\n return true;\n } // $FlowFixMe[prop-missing]: need a better way to handle this...\n\n\n next = next.parentNode || next.host;\n } while (next);\n } // Give up, the result is false\n\n\n return false;\n}","import getWindow from \"./getWindow.js\";\nexport default function getComputedStyle(element) {\n return getWindow(element).getComputedStyle(element);\n}","import getNodeName from \"./getNodeName.js\";\nexport default function isTableElement(element) {\n return ['table', 'td', 'th'].indexOf(getNodeName(element)) >= 0;\n}","import { isElement } from \"./instanceOf.js\";\nexport default function getDocumentElement(element) {\n // $FlowFixMe[incompatible-return]: assume body is always available\n return ((isElement(element) ? element.ownerDocument : // $FlowFixMe[prop-missing]\n element.document) || window.document).documentElement;\n}","import getNodeName from \"./getNodeName.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport { isShadowRoot } from \"./instanceOf.js\";\nexport default function getParentNode(element) {\n if (getNodeName(element) === 'html') {\n return element;\n }\n\n return (// this is a quicker (but less type safe) way to save quite some bytes from the bundle\n // $FlowFixMe[incompatible-return]\n // $FlowFixMe[prop-missing]\n element.assignedSlot || // step into the shadow DOM of the parent of a slotted node\n element.parentNode || ( // DOM Element detected\n isShadowRoot(element) ? element.host : null) || // ShadowRoot detected\n // $FlowFixMe[incompatible-call]: HTMLElement is a Node\n getDocumentElement(element) // fallback\n\n );\n}","import getWindow from \"./getWindow.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isHTMLElement, isShadowRoot } from \"./instanceOf.js\";\nimport isTableElement from \"./isTableElement.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getUAString from \"../utils/userAgent.js\";\n\nfunction getTrueOffsetParent(element) {\n if (!isHTMLElement(element) || // https://github.com/popperjs/popper-core/issues/837\n getComputedStyle(element).position === 'fixed') {\n return null;\n }\n\n return element.offsetParent;\n} // `.offsetParent` reports `null` for fixed elements, while absolute elements\n// return the containing block\n\n\nfunction getContainingBlock(element) {\n var isFirefox = /firefox/i.test(getUAString());\n var isIE = /Trident/i.test(getUAString());\n\n if (isIE && isHTMLElement(element)) {\n // In IE 9, 10 and 11 fixed elements containing block is always established by the viewport\n var elementCss = getComputedStyle(element);\n\n if (elementCss.position === 'fixed') {\n return null;\n }\n }\n\n var currentNode = getParentNode(element);\n\n if (isShadowRoot(currentNode)) {\n currentNode = currentNode.host;\n }\n\n while (isHTMLElement(currentNode) && ['html', 'body'].indexOf(getNodeName(currentNode)) < 0) {\n var css = getComputedStyle(currentNode); // This is non-exhaustive but covers the most common CSS properties that\n // create a containing block.\n // https://developer.mozilla.org/en-US/docs/Web/CSS/Containing_block#identifying_the_containing_block\n\n if (css.transform !== 'none' || css.perspective !== 'none' || css.contain === 'paint' || ['transform', 'perspective'].indexOf(css.willChange) !== -1 || isFirefox && css.willChange === 'filter' || isFirefox && css.filter && css.filter !== 'none') {\n return currentNode;\n } else {\n currentNode = currentNode.parentNode;\n }\n }\n\n return null;\n} // Gets the closest ancestor positioned element. Handles some edge cases,\n// such as table ancestors and cross browser bugs.\n\n\nexport default function getOffsetParent(element) {\n var window = getWindow(element);\n var offsetParent = getTrueOffsetParent(element);\n\n while (offsetParent && isTableElement(offsetParent) && getComputedStyle(offsetParent).position === 'static') {\n offsetParent = getTrueOffsetParent(offsetParent);\n }\n\n if (offsetParent && (getNodeName(offsetParent) === 'html' || getNodeName(offsetParent) === 'body' && getComputedStyle(offsetParent).position === 'static')) {\n return window;\n }\n\n return offsetParent || getContainingBlock(element) || window;\n}","export default function getMainAxisFromPlacement(placement) {\n return ['top', 'bottom'].indexOf(placement) >= 0 ? 'x' : 'y';\n}","import { max as mathMax, min as mathMin } from \"./math.js\";\nexport function within(min, value, max) {\n return mathMax(min, mathMin(value, max));\n}\nexport function withinMaxClamp(min, value, max) {\n var v = within(min, value, max);\n return v > max ? max : v;\n}","import getFreshSideObject from \"./getFreshSideObject.js\";\nexport default function mergePaddingObject(paddingObject) {\n return Object.assign({}, getFreshSideObject(), paddingObject);\n}","export default function getFreshSideObject() {\n return {\n top: 0,\n right: 0,\n bottom: 0,\n left: 0\n };\n}","export default function expandToHashMap(value, keys) {\n return keys.reduce(function (hashMap, key) {\n hashMap[key] = value;\n return hashMap;\n }, {});\n}","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport contains from \"../dom-utils/contains.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport { within } from \"../utils/within.js\";\nimport mergePaddingObject from \"../utils/mergePaddingObject.js\";\nimport expandToHashMap from \"../utils/expandToHashMap.js\";\nimport { left, right, basePlacements, top, bottom } from \"../enums.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar toPaddingObject = function toPaddingObject(padding, state) {\n padding = typeof padding === 'function' ? padding(Object.assign({}, state.rects, {\n placement: state.placement\n })) : padding;\n return mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n};\n\nfunction arrow(_ref) {\n var _state$modifiersData$;\n\n var state = _ref.state,\n name = _ref.name,\n options = _ref.options;\n var arrowElement = state.elements.arrow;\n var popperOffsets = state.modifiersData.popperOffsets;\n var basePlacement = getBasePlacement(state.placement);\n var axis = getMainAxisFromPlacement(basePlacement);\n var isVertical = [left, right].indexOf(basePlacement) >= 0;\n var len = isVertical ? 'height' : 'width';\n\n if (!arrowElement || !popperOffsets) {\n return;\n }\n\n var paddingObject = toPaddingObject(options.padding, state);\n var arrowRect = getLayoutRect(arrowElement);\n var minProp = axis === 'y' ? top : left;\n var maxProp = axis === 'y' ? bottom : right;\n var endDiff = state.rects.reference[len] + state.rects.reference[axis] - popperOffsets[axis] - state.rects.popper[len];\n var startDiff = popperOffsets[axis] - state.rects.reference[axis];\n var arrowOffsetParent = getOffsetParent(arrowElement);\n var clientSize = arrowOffsetParent ? axis === 'y' ? arrowOffsetParent.clientHeight || 0 : arrowOffsetParent.clientWidth || 0 : 0;\n var centerToReference = endDiff / 2 - startDiff / 2; // Make sure the arrow doesn't overflow the popper if the center point is\n // outside of the popper bounds\n\n var min = paddingObject[minProp];\n var max = clientSize - arrowRect[len] - paddingObject[maxProp];\n var center = clientSize / 2 - arrowRect[len] / 2 + centerToReference;\n var offset = within(min, center, max); // Prevents breaking syntax highlighting...\n\n var axisProp = axis;\n state.modifiersData[name] = (_state$modifiersData$ = {}, _state$modifiersData$[axisProp] = offset, _state$modifiersData$.centerOffset = offset - center, _state$modifiersData$);\n}\n\nfunction effect(_ref2) {\n var state = _ref2.state,\n options = _ref2.options;\n var _options$element = options.element,\n arrowElement = _options$element === void 0 ? '[data-popper-arrow]' : _options$element;\n\n if (arrowElement == null) {\n return;\n } // CSS selector\n\n\n if (typeof arrowElement === 'string') {\n arrowElement = state.elements.popper.querySelector(arrowElement);\n\n if (!arrowElement) {\n return;\n }\n }\n\n if (!contains(state.elements.popper, arrowElement)) {\n return;\n }\n\n state.elements.arrow = arrowElement;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'arrow',\n enabled: true,\n phase: 'main',\n fn: arrow,\n effect: effect,\n requires: ['popperOffsets'],\n requiresIfExists: ['preventOverflow']\n};","export default function getVariation(placement) {\n return placement.split('-')[1];\n}","import { top, left, right, bottom, end } from \"../enums.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getWindow from \"../dom-utils/getWindow.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getComputedStyle from \"../dom-utils/getComputedStyle.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport { round } from \"../utils/math.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar unsetSides = {\n top: 'auto',\n right: 'auto',\n bottom: 'auto',\n left: 'auto'\n}; // Round the offsets to the nearest suitable subpixel based on the DPR.\n// Zooming can change the DPR, but it seems to report a value that will\n// cleanly divide the values into the appropriate subpixels.\n\nfunction roundOffsetsByDPR(_ref, win) {\n var x = _ref.x,\n y = _ref.y;\n var dpr = win.devicePixelRatio || 1;\n return {\n x: round(x * dpr) / dpr || 0,\n y: round(y * dpr) / dpr || 0\n };\n}\n\nexport function mapToStyles(_ref2) {\n var _Object$assign2;\n\n var popper = _ref2.popper,\n popperRect = _ref2.popperRect,\n placement = _ref2.placement,\n variation = _ref2.variation,\n offsets = _ref2.offsets,\n position = _ref2.position,\n gpuAcceleration = _ref2.gpuAcceleration,\n adaptive = _ref2.adaptive,\n roundOffsets = _ref2.roundOffsets,\n isFixed = _ref2.isFixed;\n var _offsets$x = offsets.x,\n x = _offsets$x === void 0 ? 0 : _offsets$x,\n _offsets$y = offsets.y,\n y = _offsets$y === void 0 ? 0 : _offsets$y;\n\n var _ref3 = typeof roundOffsets === 'function' ? roundOffsets({\n x: x,\n y: y\n }) : {\n x: x,\n y: y\n };\n\n x = _ref3.x;\n y = _ref3.y;\n var hasX = offsets.hasOwnProperty('x');\n var hasY = offsets.hasOwnProperty('y');\n var sideX = left;\n var sideY = top;\n var win = window;\n\n if (adaptive) {\n var offsetParent = getOffsetParent(popper);\n var heightProp = 'clientHeight';\n var widthProp = 'clientWidth';\n\n if (offsetParent === getWindow(popper)) {\n offsetParent = getDocumentElement(popper);\n\n if (getComputedStyle(offsetParent).position !== 'static' && position === 'absolute') {\n heightProp = 'scrollHeight';\n widthProp = 'scrollWidth';\n }\n } // $FlowFixMe[incompatible-cast]: force type refinement, we compare offsetParent with window above, but Flow doesn't detect it\n\n\n offsetParent = offsetParent;\n\n if (placement === top || (placement === left || placement === right) && variation === end) {\n sideY = bottom;\n var offsetY = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.height : // $FlowFixMe[prop-missing]\n offsetParent[heightProp];\n y -= offsetY - popperRect.height;\n y *= gpuAcceleration ? 1 : -1;\n }\n\n if (placement === left || (placement === top || placement === bottom) && variation === end) {\n sideX = right;\n var offsetX = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.width : // $FlowFixMe[prop-missing]\n offsetParent[widthProp];\n x -= offsetX - popperRect.width;\n x *= gpuAcceleration ? 1 : -1;\n }\n }\n\n var commonStyles = Object.assign({\n position: position\n }, adaptive && unsetSides);\n\n var _ref4 = roundOffsets === true ? roundOffsetsByDPR({\n x: x,\n y: y\n }, getWindow(popper)) : {\n x: x,\n y: y\n };\n\n x = _ref4.x;\n y = _ref4.y;\n\n if (gpuAcceleration) {\n var _Object$assign;\n\n return Object.assign({}, commonStyles, (_Object$assign = {}, _Object$assign[sideY] = hasY ? '0' : '', _Object$assign[sideX] = hasX ? '0' : '', _Object$assign.transform = (win.devicePixelRatio || 1) <= 1 ? \"translate(\" + x + \"px, \" + y + \"px)\" : \"translate3d(\" + x + \"px, \" + y + \"px, 0)\", _Object$assign));\n }\n\n return Object.assign({}, commonStyles, (_Object$assign2 = {}, _Object$assign2[sideY] = hasY ? y + \"px\" : '', _Object$assign2[sideX] = hasX ? x + \"px\" : '', _Object$assign2.transform = '', _Object$assign2));\n}\n\nfunction computeStyles(_ref5) {\n var state = _ref5.state,\n options = _ref5.options;\n var _options$gpuAccelerat = options.gpuAcceleration,\n gpuAcceleration = _options$gpuAccelerat === void 0 ? true : _options$gpuAccelerat,\n _options$adaptive = options.adaptive,\n adaptive = _options$adaptive === void 0 ? true : _options$adaptive,\n _options$roundOffsets = options.roundOffsets,\n roundOffsets = _options$roundOffsets === void 0 ? true : _options$roundOffsets;\n var commonStyles = {\n placement: getBasePlacement(state.placement),\n variation: getVariation(state.placement),\n popper: state.elements.popper,\n popperRect: state.rects.popper,\n gpuAcceleration: gpuAcceleration,\n isFixed: state.options.strategy === 'fixed'\n };\n\n if (state.modifiersData.popperOffsets != null) {\n state.styles.popper = Object.assign({}, state.styles.popper, mapToStyles(Object.assign({}, commonStyles, {\n offsets: state.modifiersData.popperOffsets,\n position: state.options.strategy,\n adaptive: adaptive,\n roundOffsets: roundOffsets\n })));\n }\n\n if (state.modifiersData.arrow != null) {\n state.styles.arrow = Object.assign({}, state.styles.arrow, mapToStyles(Object.assign({}, commonStyles, {\n offsets: state.modifiersData.arrow,\n position: 'absolute',\n adaptive: false,\n roundOffsets: roundOffsets\n })));\n }\n\n state.attributes.popper = Object.assign({}, state.attributes.popper, {\n 'data-popper-placement': state.placement\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'computeStyles',\n enabled: true,\n phase: 'beforeWrite',\n fn: computeStyles,\n data: {}\n};","import getWindow from \"../dom-utils/getWindow.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar passive = {\n passive: true\n};\n\nfunction effect(_ref) {\n var state = _ref.state,\n instance = _ref.instance,\n options = _ref.options;\n var _options$scroll = options.scroll,\n scroll = _options$scroll === void 0 ? true : _options$scroll,\n _options$resize = options.resize,\n resize = _options$resize === void 0 ? true : _options$resize;\n var window = getWindow(state.elements.popper);\n var scrollParents = [].concat(state.scrollParents.reference, state.scrollParents.popper);\n\n if (scroll) {\n scrollParents.forEach(function (scrollParent) {\n scrollParent.addEventListener('scroll', instance.update, passive);\n });\n }\n\n if (resize) {\n window.addEventListener('resize', instance.update, passive);\n }\n\n return function () {\n if (scroll) {\n scrollParents.forEach(function (scrollParent) {\n scrollParent.removeEventListener('scroll', instance.update, passive);\n });\n }\n\n if (resize) {\n window.removeEventListener('resize', instance.update, passive);\n }\n };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'eventListeners',\n enabled: true,\n phase: 'write',\n fn: function fn() {},\n effect: effect,\n data: {}\n};","var hash = {\n left: 'right',\n right: 'left',\n bottom: 'top',\n top: 'bottom'\n};\nexport default function getOppositePlacement(placement) {\n return placement.replace(/left|right|bottom|top/g, function (matched) {\n return hash[matched];\n });\n}","var hash = {\n start: 'end',\n end: 'start'\n};\nexport default function getOppositeVariationPlacement(placement) {\n return placement.replace(/start|end/g, function (matched) {\n return hash[matched];\n });\n}","import getWindow from \"./getWindow.js\";\nexport default function getWindowScroll(node) {\n var win = getWindow(node);\n var scrollLeft = win.pageXOffset;\n var scrollTop = win.pageYOffset;\n return {\n scrollLeft: scrollLeft,\n scrollTop: scrollTop\n };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nexport default function getWindowScrollBarX(element) {\n // If has a CSS width greater than the viewport, then this will be\n // incorrect for RTL.\n // Popper 1 is broken in this case and never had a bug report so let's assume\n // it's not an issue. I don't think anyone ever specifies width on \n // anyway.\n // Browsers where the left scrollbar doesn't cause an issue report `0` for\n // this (e.g. Edge 2019, IE11, Safari)\n return getBoundingClientRect(getDocumentElement(element)).left + getWindowScroll(element).scrollLeft;\n}","import getComputedStyle from \"./getComputedStyle.js\";\nexport default function isScrollParent(element) {\n // Firefox wants us to check `-x` and `-y` variations as well\n var _getComputedStyle = getComputedStyle(element),\n overflow = _getComputedStyle.overflow,\n overflowX = _getComputedStyle.overflowX,\n overflowY = _getComputedStyle.overflowY;\n\n return /auto|scroll|overlay|hidden/.test(overflow + overflowY + overflowX);\n}","import getParentNode from \"./getParentNode.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nexport default function getScrollParent(node) {\n if (['html', 'body', '#document'].indexOf(getNodeName(node)) >= 0) {\n // $FlowFixMe[incompatible-return]: assume body is always available\n return node.ownerDocument.body;\n }\n\n if (isHTMLElement(node) && isScrollParent(node)) {\n return node;\n }\n\n return getScrollParent(getParentNode(node));\n}","import getScrollParent from \"./getScrollParent.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getWindow from \"./getWindow.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n/*\ngiven a DOM element, return the list of all scroll parents, up the list of ancesors\nuntil we get to the top window object. This list is what we attach scroll listeners\nto, because if any of these parent elements scroll, we'll need to re-calculate the\nreference element's position.\n*/\n\nexport default function listScrollParents(element, list) {\n var _element$ownerDocumen;\n\n if (list === void 0) {\n list = [];\n }\n\n var scrollParent = getScrollParent(element);\n var isBody = scrollParent === ((_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body);\n var win = getWindow(scrollParent);\n var target = isBody ? [win].concat(win.visualViewport || [], isScrollParent(scrollParent) ? scrollParent : []) : scrollParent;\n var updatedList = list.concat(target);\n return isBody ? updatedList : // $FlowFixMe[incompatible-call]: isBody tells us target will be an HTMLElement here\n updatedList.concat(listScrollParents(getParentNode(target)));\n}","export default function rectToClientRect(rect) {\n return Object.assign({}, rect, {\n left: rect.x,\n top: rect.y,\n right: rect.x + rect.width,\n bottom: rect.y + rect.height\n });\n}","import { viewport } from \"../enums.js\";\nimport getViewportRect from \"./getViewportRect.js\";\nimport getDocumentRect from \"./getDocumentRect.js\";\nimport listScrollParents from \"./listScrollParents.js\";\nimport getOffsetParent from \"./getOffsetParent.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport contains from \"./contains.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport rectToClientRect from \"../utils/rectToClientRect.js\";\nimport { max, min } from \"../utils/math.js\";\n\nfunction getInnerBoundingClientRect(element, strategy) {\n var rect = getBoundingClientRect(element, false, strategy === 'fixed');\n rect.top = rect.top + element.clientTop;\n rect.left = rect.left + element.clientLeft;\n rect.bottom = rect.top + element.clientHeight;\n rect.right = rect.left + element.clientWidth;\n rect.width = element.clientWidth;\n rect.height = element.clientHeight;\n rect.x = rect.left;\n rect.y = rect.top;\n return rect;\n}\n\nfunction getClientRectFromMixedType(element, clippingParent, strategy) {\n return clippingParent === viewport ? rectToClientRect(getViewportRect(element, strategy)) : isElement(clippingParent) ? getInnerBoundingClientRect(clippingParent, strategy) : rectToClientRect(getDocumentRect(getDocumentElement(element)));\n} // A \"clipping parent\" is an overflowable container with the characteristic of\n// clipping (or hiding) overflowing elements with a position different from\n// `initial`\n\n\nfunction getClippingParents(element) {\n var clippingParents = listScrollParents(getParentNode(element));\n var canEscapeClipping = ['absolute', 'fixed'].indexOf(getComputedStyle(element).position) >= 0;\n var clipperElement = canEscapeClipping && isHTMLElement(element) ? getOffsetParent(element) : element;\n\n if (!isElement(clipperElement)) {\n return [];\n } // $FlowFixMe[incompatible-return]: https://github.com/facebook/flow/issues/1414\n\n\n return clippingParents.filter(function (clippingParent) {\n return isElement(clippingParent) && contains(clippingParent, clipperElement) && getNodeName(clippingParent) !== 'body';\n });\n} // Gets the maximum area that the element is visible in due to any number of\n// clipping parents\n\n\nexport default function getClippingRect(element, boundary, rootBoundary, strategy) {\n var mainClippingParents = boundary === 'clippingParents' ? getClippingParents(element) : [].concat(boundary);\n var clippingParents = [].concat(mainClippingParents, [rootBoundary]);\n var firstClippingParent = clippingParents[0];\n var clippingRect = clippingParents.reduce(function (accRect, clippingParent) {\n var rect = getClientRectFromMixedType(element, clippingParent, strategy);\n accRect.top = max(rect.top, accRect.top);\n accRect.right = min(rect.right, accRect.right);\n accRect.bottom = min(rect.bottom, accRect.bottom);\n accRect.left = max(rect.left, accRect.left);\n return accRect;\n }, getClientRectFromMixedType(element, firstClippingParent, strategy));\n clippingRect.width = clippingRect.right - clippingRect.left;\n clippingRect.height = clippingRect.bottom - clippingRect.top;\n clippingRect.x = clippingRect.left;\n clippingRect.y = clippingRect.top;\n return clippingRect;\n}","import getWindow from \"./getWindow.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getViewportRect(element, strategy) {\n var win = getWindow(element);\n var html = getDocumentElement(element);\n var visualViewport = win.visualViewport;\n var width = html.clientWidth;\n var height = html.clientHeight;\n var x = 0;\n var y = 0;\n\n if (visualViewport) {\n width = visualViewport.width;\n height = visualViewport.height;\n var layoutViewport = isLayoutViewport();\n\n if (layoutViewport || !layoutViewport && strategy === 'fixed') {\n x = visualViewport.offsetLeft;\n y = visualViewport.offsetTop;\n }\n }\n\n return {\n width: width,\n height: height,\n x: x + getWindowScrollBarX(element),\n y: y\n };\n}","import getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nimport { max } from \"../utils/math.js\"; // Gets the entire size of the scrollable document area, even extending outside\n// of the `` and `` rect bounds if horizontally scrollable\n\nexport default function getDocumentRect(element) {\n var _element$ownerDocumen;\n\n var html = getDocumentElement(element);\n var winScroll = getWindowScroll(element);\n var body = (_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body;\n var width = max(html.scrollWidth, html.clientWidth, body ? body.scrollWidth : 0, body ? body.clientWidth : 0);\n var height = max(html.scrollHeight, html.clientHeight, body ? body.scrollHeight : 0, body ? body.clientHeight : 0);\n var x = -winScroll.scrollLeft + getWindowScrollBarX(element);\n var y = -winScroll.scrollTop;\n\n if (getComputedStyle(body || html).direction === 'rtl') {\n x += max(html.clientWidth, body ? body.clientWidth : 0) - width;\n }\n\n return {\n width: width,\n height: height,\n x: x,\n y: y\n };\n}","import getBasePlacement from \"./getBasePlacement.js\";\nimport getVariation from \"./getVariation.js\";\nimport getMainAxisFromPlacement from \"./getMainAxisFromPlacement.js\";\nimport { top, right, bottom, left, start, end } from \"../enums.js\";\nexport default function computeOffsets(_ref) {\n var reference = _ref.reference,\n element = _ref.element,\n placement = _ref.placement;\n var basePlacement = placement ? getBasePlacement(placement) : null;\n var variation = placement ? getVariation(placement) : null;\n var commonX = reference.x + reference.width / 2 - element.width / 2;\n var commonY = reference.y + reference.height / 2 - element.height / 2;\n var offsets;\n\n switch (basePlacement) {\n case top:\n offsets = {\n x: commonX,\n y: reference.y - element.height\n };\n break;\n\n case bottom:\n offsets = {\n x: commonX,\n y: reference.y + reference.height\n };\n break;\n\n case right:\n offsets = {\n x: reference.x + reference.width,\n y: commonY\n };\n break;\n\n case left:\n offsets = {\n x: reference.x - element.width,\n y: commonY\n };\n break;\n\n default:\n offsets = {\n x: reference.x,\n y: reference.y\n };\n }\n\n var mainAxis = basePlacement ? getMainAxisFromPlacement(basePlacement) : null;\n\n if (mainAxis != null) {\n var len = mainAxis === 'y' ? 'height' : 'width';\n\n switch (variation) {\n case start:\n offsets[mainAxis] = offsets[mainAxis] - (reference[len] / 2 - element[len] / 2);\n break;\n\n case end:\n offsets[mainAxis] = offsets[mainAxis] + (reference[len] / 2 - element[len] / 2);\n break;\n\n default:\n }\n }\n\n return offsets;\n}","import getClippingRect from \"../dom-utils/getClippingRect.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getBoundingClientRect from \"../dom-utils/getBoundingClientRect.js\";\nimport computeOffsets from \"./computeOffsets.js\";\nimport rectToClientRect from \"./rectToClientRect.js\";\nimport { clippingParents, reference, popper, bottom, top, right, basePlacements, viewport } from \"../enums.js\";\nimport { isElement } from \"../dom-utils/instanceOf.js\";\nimport mergePaddingObject from \"./mergePaddingObject.js\";\nimport expandToHashMap from \"./expandToHashMap.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport default function detectOverflow(state, options) {\n if (options === void 0) {\n options = {};\n }\n\n var _options = options,\n _options$placement = _options.placement,\n placement = _options$placement === void 0 ? state.placement : _options$placement,\n _options$strategy = _options.strategy,\n strategy = _options$strategy === void 0 ? state.strategy : _options$strategy,\n _options$boundary = _options.boundary,\n boundary = _options$boundary === void 0 ? clippingParents : _options$boundary,\n _options$rootBoundary = _options.rootBoundary,\n rootBoundary = _options$rootBoundary === void 0 ? viewport : _options$rootBoundary,\n _options$elementConte = _options.elementContext,\n elementContext = _options$elementConte === void 0 ? popper : _options$elementConte,\n _options$altBoundary = _options.altBoundary,\n altBoundary = _options$altBoundary === void 0 ? false : _options$altBoundary,\n _options$padding = _options.padding,\n padding = _options$padding === void 0 ? 0 : _options$padding;\n var paddingObject = mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n var altContext = elementContext === popper ? reference : popper;\n var popperRect = state.rects.popper;\n var element = state.elements[altBoundary ? altContext : elementContext];\n var clippingClientRect = getClippingRect(isElement(element) ? element : element.contextElement || getDocumentElement(state.elements.popper), boundary, rootBoundary, strategy);\n var referenceClientRect = getBoundingClientRect(state.elements.reference);\n var popperOffsets = computeOffsets({\n reference: referenceClientRect,\n element: popperRect,\n strategy: 'absolute',\n placement: placement\n });\n var popperClientRect = rectToClientRect(Object.assign({}, popperRect, popperOffsets));\n var elementClientRect = elementContext === popper ? popperClientRect : referenceClientRect; // positive = overflowing the clipping rect\n // 0 or negative = within the clipping rect\n\n var overflowOffsets = {\n top: clippingClientRect.top - elementClientRect.top + paddingObject.top,\n bottom: elementClientRect.bottom - clippingClientRect.bottom + paddingObject.bottom,\n left: clippingClientRect.left - elementClientRect.left + paddingObject.left,\n right: elementClientRect.right - clippingClientRect.right + paddingObject.right\n };\n var offsetData = state.modifiersData.offset; // Offsets can be applied only to the popper element\n\n if (elementContext === popper && offsetData) {\n var offset = offsetData[placement];\n Object.keys(overflowOffsets).forEach(function (key) {\n var multiply = [right, bottom].indexOf(key) >= 0 ? 1 : -1;\n var axis = [top, bottom].indexOf(key) >= 0 ? 'y' : 'x';\n overflowOffsets[key] += offset[axis] * multiply;\n });\n }\n\n return overflowOffsets;\n}","import getVariation from \"./getVariation.js\";\nimport { variationPlacements, basePlacements, placements as allPlacements } from \"../enums.js\";\nimport detectOverflow from \"./detectOverflow.js\";\nimport getBasePlacement from \"./getBasePlacement.js\";\nexport default function computeAutoPlacement(state, options) {\n if (options === void 0) {\n options = {};\n }\n\n var _options = options,\n placement = _options.placement,\n boundary = _options.boundary,\n rootBoundary = _options.rootBoundary,\n padding = _options.padding,\n flipVariations = _options.flipVariations,\n _options$allowedAutoP = _options.allowedAutoPlacements,\n allowedAutoPlacements = _options$allowedAutoP === void 0 ? allPlacements : _options$allowedAutoP;\n var variation = getVariation(placement);\n var placements = variation ? flipVariations ? variationPlacements : variationPlacements.filter(function (placement) {\n return getVariation(placement) === variation;\n }) : basePlacements;\n var allowedPlacements = placements.filter(function (placement) {\n return allowedAutoPlacements.indexOf(placement) >= 0;\n });\n\n if (allowedPlacements.length === 0) {\n allowedPlacements = placements;\n } // $FlowFixMe[incompatible-type]: Flow seems to have problems with two array unions...\n\n\n var overflows = allowedPlacements.reduce(function (acc, placement) {\n acc[placement] = detectOverflow(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding\n })[getBasePlacement(placement)];\n return acc;\n }, {});\n return Object.keys(overflows).sort(function (a, b) {\n return overflows[a] - overflows[b];\n });\n}","import getOppositePlacement from \"../utils/getOppositePlacement.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getOppositeVariationPlacement from \"../utils/getOppositeVariationPlacement.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport computeAutoPlacement from \"../utils/computeAutoPlacement.js\";\nimport { bottom, top, start, right, left, auto } from \"../enums.js\";\nimport getVariation from \"../utils/getVariation.js\"; // eslint-disable-next-line import/no-unused-modules\n\nfunction getExpandedFallbackPlacements(placement) {\n if (getBasePlacement(placement) === auto) {\n return [];\n }\n\n var oppositePlacement = getOppositePlacement(placement);\n return [getOppositeVariationPlacement(placement), oppositePlacement, getOppositeVariationPlacement(oppositePlacement)];\n}\n\nfunction flip(_ref) {\n var state = _ref.state,\n options = _ref.options,\n name = _ref.name;\n\n if (state.modifiersData[name]._skip) {\n return;\n }\n\n var _options$mainAxis = options.mainAxis,\n checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n _options$altAxis = options.altAxis,\n checkAltAxis = _options$altAxis === void 0 ? true : _options$altAxis,\n specifiedFallbackPlacements = options.fallbackPlacements,\n padding = options.padding,\n boundary = options.boundary,\n rootBoundary = options.rootBoundary,\n altBoundary = options.altBoundary,\n _options$flipVariatio = options.flipVariations,\n flipVariations = _options$flipVariatio === void 0 ? true : _options$flipVariatio,\n allowedAutoPlacements = options.allowedAutoPlacements;\n var preferredPlacement = state.options.placement;\n var basePlacement = getBasePlacement(preferredPlacement);\n var isBasePlacement = basePlacement === preferredPlacement;\n var fallbackPlacements = specifiedFallbackPlacements || (isBasePlacement || !flipVariations ? [getOppositePlacement(preferredPlacement)] : getExpandedFallbackPlacements(preferredPlacement));\n var placements = [preferredPlacement].concat(fallbackPlacements).reduce(function (acc, placement) {\n return acc.concat(getBasePlacement(placement) === auto ? computeAutoPlacement(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding,\n flipVariations: flipVariations,\n allowedAutoPlacements: allowedAutoPlacements\n }) : placement);\n }, []);\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var checksMap = new Map();\n var makeFallbackChecks = true;\n var firstFittingPlacement = placements[0];\n\n for (var i = 0; i < placements.length; i++) {\n var placement = placements[i];\n\n var _basePlacement = getBasePlacement(placement);\n\n var isStartVariation = getVariation(placement) === start;\n var isVertical = [top, bottom].indexOf(_basePlacement) >= 0;\n var len = isVertical ? 'width' : 'height';\n var overflow = detectOverflow(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n altBoundary: altBoundary,\n padding: padding\n });\n var mainVariationSide = isVertical ? isStartVariation ? right : left : isStartVariation ? bottom : top;\n\n if (referenceRect[len] > popperRect[len]) {\n mainVariationSide = getOppositePlacement(mainVariationSide);\n }\n\n var altVariationSide = getOppositePlacement(mainVariationSide);\n var checks = [];\n\n if (checkMainAxis) {\n checks.push(overflow[_basePlacement] <= 0);\n }\n\n if (checkAltAxis) {\n checks.push(overflow[mainVariationSide] <= 0, overflow[altVariationSide] <= 0);\n }\n\n if (checks.every(function (check) {\n return check;\n })) {\n firstFittingPlacement = placement;\n makeFallbackChecks = false;\n break;\n }\n\n checksMap.set(placement, checks);\n }\n\n if (makeFallbackChecks) {\n // `2` may be desired in some cases – research later\n var numberOfChecks = flipVariations ? 3 : 1;\n\n var _loop = function _loop(_i) {\n var fittingPlacement = placements.find(function (placement) {\n var checks = checksMap.get(placement);\n\n if (checks) {\n return checks.slice(0, _i).every(function (check) {\n return check;\n });\n }\n });\n\n if (fittingPlacement) {\n firstFittingPlacement = fittingPlacement;\n return \"break\";\n }\n };\n\n for (var _i = numberOfChecks; _i > 0; _i--) {\n var _ret = _loop(_i);\n\n if (_ret === \"break\") break;\n }\n }\n\n if (state.placement !== firstFittingPlacement) {\n state.modifiersData[name]._skip = true;\n state.placement = firstFittingPlacement;\n state.reset = true;\n }\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'flip',\n enabled: true,\n phase: 'main',\n fn: flip,\n requiresIfExists: ['offset'],\n data: {\n _skip: false\n }\n};","import { top, bottom, left, right } from \"../enums.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\n\nfunction getSideOffsets(overflow, rect, preventedOffsets) {\n if (preventedOffsets === void 0) {\n preventedOffsets = {\n x: 0,\n y: 0\n };\n }\n\n return {\n top: overflow.top - rect.height - preventedOffsets.y,\n right: overflow.right - rect.width + preventedOffsets.x,\n bottom: overflow.bottom - rect.height + preventedOffsets.y,\n left: overflow.left - rect.width - preventedOffsets.x\n };\n}\n\nfunction isAnySideFullyClipped(overflow) {\n return [top, right, bottom, left].some(function (side) {\n return overflow[side] >= 0;\n });\n}\n\nfunction hide(_ref) {\n var state = _ref.state,\n name = _ref.name;\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var preventedOffsets = state.modifiersData.preventOverflow;\n var referenceOverflow = detectOverflow(state, {\n elementContext: 'reference'\n });\n var popperAltOverflow = detectOverflow(state, {\n altBoundary: true\n });\n var referenceClippingOffsets = getSideOffsets(referenceOverflow, referenceRect);\n var popperEscapeOffsets = getSideOffsets(popperAltOverflow, popperRect, preventedOffsets);\n var isReferenceHidden = isAnySideFullyClipped(referenceClippingOffsets);\n var hasPopperEscaped = isAnySideFullyClipped(popperEscapeOffsets);\n state.modifiersData[name] = {\n referenceClippingOffsets: referenceClippingOffsets,\n popperEscapeOffsets: popperEscapeOffsets,\n isReferenceHidden: isReferenceHidden,\n hasPopperEscaped: hasPopperEscaped\n };\n state.attributes.popper = Object.assign({}, state.attributes.popper, {\n 'data-popper-reference-hidden': isReferenceHidden,\n 'data-popper-escaped': hasPopperEscaped\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'hide',\n enabled: true,\n phase: 'main',\n requiresIfExists: ['preventOverflow'],\n fn: hide\n};","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport { top, left, right, placements } from \"../enums.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport function distanceAndSkiddingToXY(placement, rects, offset) {\n var basePlacement = getBasePlacement(placement);\n var invertDistance = [left, top].indexOf(basePlacement) >= 0 ? -1 : 1;\n\n var _ref = typeof offset === 'function' ? offset(Object.assign({}, rects, {\n placement: placement\n })) : offset,\n skidding = _ref[0],\n distance = _ref[1];\n\n skidding = skidding || 0;\n distance = (distance || 0) * invertDistance;\n return [left, right].indexOf(basePlacement) >= 0 ? {\n x: distance,\n y: skidding\n } : {\n x: skidding,\n y: distance\n };\n}\n\nfunction offset(_ref2) {\n var state = _ref2.state,\n options = _ref2.options,\n name = _ref2.name;\n var _options$offset = options.offset,\n offset = _options$offset === void 0 ? [0, 0] : _options$offset;\n var data = placements.reduce(function (acc, placement) {\n acc[placement] = distanceAndSkiddingToXY(placement, state.rects, offset);\n return acc;\n }, {});\n var _data$state$placement = data[state.placement],\n x = _data$state$placement.x,\n y = _data$state$placement.y;\n\n if (state.modifiersData.popperOffsets != null) {\n state.modifiersData.popperOffsets.x += x;\n state.modifiersData.popperOffsets.y += y;\n }\n\n state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'offset',\n enabled: true,\n phase: 'main',\n requires: ['popperOffsets'],\n fn: offset\n};","import computeOffsets from \"../utils/computeOffsets.js\";\n\nfunction popperOffsets(_ref) {\n var state = _ref.state,\n name = _ref.name;\n // Offsets are the actual position the popper needs to have to be\n // properly positioned near its reference element\n // This is the most basic placement, and will be adjusted by\n // the modifiers in the next step\n state.modifiersData[name] = computeOffsets({\n reference: state.rects.reference,\n element: state.rects.popper,\n strategy: 'absolute',\n placement: state.placement\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'popperOffsets',\n enabled: true,\n phase: 'read',\n fn: popperOffsets,\n data: {}\n};","import { top, left, right, bottom, start } from \"../enums.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport getAltAxis from \"../utils/getAltAxis.js\";\nimport { within, withinMaxClamp } from \"../utils/within.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport getFreshSideObject from \"../utils/getFreshSideObject.js\";\nimport { min as mathMin, max as mathMax } from \"../utils/math.js\";\n\nfunction preventOverflow(_ref) {\n var state = _ref.state,\n options = _ref.options,\n name = _ref.name;\n var _options$mainAxis = options.mainAxis,\n checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n _options$altAxis = options.altAxis,\n checkAltAxis = _options$altAxis === void 0 ? false : _options$altAxis,\n boundary = options.boundary,\n rootBoundary = options.rootBoundary,\n altBoundary = options.altBoundary,\n padding = options.padding,\n _options$tether = options.tether,\n tether = _options$tether === void 0 ? true : _options$tether,\n _options$tetherOffset = options.tetherOffset,\n tetherOffset = _options$tetherOffset === void 0 ? 0 : _options$tetherOffset;\n var overflow = detectOverflow(state, {\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding,\n altBoundary: altBoundary\n });\n var basePlacement = getBasePlacement(state.placement);\n var variation = getVariation(state.placement);\n var isBasePlacement = !variation;\n var mainAxis = getMainAxisFromPlacement(basePlacement);\n var altAxis = getAltAxis(mainAxis);\n var popperOffsets = state.modifiersData.popperOffsets;\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var tetherOffsetValue = typeof tetherOffset === 'function' ? tetherOffset(Object.assign({}, state.rects, {\n placement: state.placement\n })) : tetherOffset;\n var normalizedTetherOffsetValue = typeof tetherOffsetValue === 'number' ? {\n mainAxis: tetherOffsetValue,\n altAxis: tetherOffsetValue\n } : Object.assign({\n mainAxis: 0,\n altAxis: 0\n }, tetherOffsetValue);\n var offsetModifierState = state.modifiersData.offset ? state.modifiersData.offset[state.placement] : null;\n var data = {\n x: 0,\n y: 0\n };\n\n if (!popperOffsets) {\n return;\n }\n\n if (checkMainAxis) {\n var _offsetModifierState$;\n\n var mainSide = mainAxis === 'y' ? top : left;\n var altSide = mainAxis === 'y' ? bottom : right;\n var len = mainAxis === 'y' ? 'height' : 'width';\n var offset = popperOffsets[mainAxis];\n var min = offset + overflow[mainSide];\n var max = offset - overflow[altSide];\n var additive = tether ? -popperRect[len] / 2 : 0;\n var minLen = variation === start ? referenceRect[len] : popperRect[len];\n var maxLen = variation === start ? -popperRect[len] : -referenceRect[len]; // We need to include the arrow in the calculation so the arrow doesn't go\n // outside the reference bounds\n\n var arrowElement = state.elements.arrow;\n var arrowRect = tether && arrowElement ? getLayoutRect(arrowElement) : {\n width: 0,\n height: 0\n };\n var arrowPaddingObject = state.modifiersData['arrow#persistent'] ? state.modifiersData['arrow#persistent'].padding : getFreshSideObject();\n var arrowPaddingMin = arrowPaddingObject[mainSide];\n var arrowPaddingMax = arrowPaddingObject[altSide]; // If the reference length is smaller than the arrow length, we don't want\n // to include its full size in the calculation. If the reference is small\n // and near the edge of a boundary, the popper can overflow even if the\n // reference is not overflowing as well (e.g. virtual elements with no\n // width or height)\n\n var arrowLen = within(0, referenceRect[len], arrowRect[len]);\n var minOffset = isBasePlacement ? referenceRect[len] / 2 - additive - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis : minLen - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis;\n var maxOffset = isBasePlacement ? -referenceRect[len] / 2 + additive + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis : maxLen + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis;\n var arrowOffsetParent = state.elements.arrow && getOffsetParent(state.elements.arrow);\n var clientOffset = arrowOffsetParent ? mainAxis === 'y' ? arrowOffsetParent.clientTop || 0 : arrowOffsetParent.clientLeft || 0 : 0;\n var offsetModifierValue = (_offsetModifierState$ = offsetModifierState == null ? void 0 : offsetModifierState[mainAxis]) != null ? _offsetModifierState$ : 0;\n var tetherMin = offset + minOffset - offsetModifierValue - clientOffset;\n var tetherMax = offset + maxOffset - offsetModifierValue;\n var preventedOffset = within(tether ? mathMin(min, tetherMin) : min, offset, tether ? mathMax(max, tetherMax) : max);\n popperOffsets[mainAxis] = preventedOffset;\n data[mainAxis] = preventedOffset - offset;\n }\n\n if (checkAltAxis) {\n var _offsetModifierState$2;\n\n var _mainSide = mainAxis === 'x' ? top : left;\n\n var _altSide = mainAxis === 'x' ? bottom : right;\n\n var _offset = popperOffsets[altAxis];\n\n var _len = altAxis === 'y' ? 'height' : 'width';\n\n var _min = _offset + overflow[_mainSide];\n\n var _max = _offset - overflow[_altSide];\n\n var isOriginSide = [top, left].indexOf(basePlacement) !== -1;\n\n var _offsetModifierValue = (_offsetModifierState$2 = offsetModifierState == null ? void 0 : offsetModifierState[altAxis]) != null ? _offsetModifierState$2 : 0;\n\n var _tetherMin = isOriginSide ? _min : _offset - referenceRect[_len] - popperRect[_len] - _offsetModifierValue + normalizedTetherOffsetValue.altAxis;\n\n var _tetherMax = isOriginSide ? _offset + referenceRect[_len] + popperRect[_len] - _offsetModifierValue - normalizedTetherOffsetValue.altAxis : _max;\n\n var _preventedOffset = tether && isOriginSide ? withinMaxClamp(_tetherMin, _offset, _tetherMax) : within(tether ? _tetherMin : _min, _offset, tether ? _tetherMax : _max);\n\n popperOffsets[altAxis] = _preventedOffset;\n data[altAxis] = _preventedOffset - _offset;\n }\n\n state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'preventOverflow',\n enabled: true,\n phase: 'main',\n fn: preventOverflow,\n requiresIfExists: ['offset']\n};","export default function getAltAxis(axis) {\n return axis === 'x' ? 'y' : 'x';\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getNodeScroll from \"./getNodeScroll.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport { round } from \"../utils/math.js\";\n\nfunction isElementScaled(element) {\n var rect = element.getBoundingClientRect();\n var scaleX = round(rect.width) / element.offsetWidth || 1;\n var scaleY = round(rect.height) / element.offsetHeight || 1;\n return scaleX !== 1 || scaleY !== 1;\n} // Returns the composite rect of an element relative to its offsetParent.\n// Composite means it takes into account transforms as well as layout.\n\n\nexport default function getCompositeRect(elementOrVirtualElement, offsetParent, isFixed) {\n if (isFixed === void 0) {\n isFixed = false;\n }\n\n var isOffsetParentAnElement = isHTMLElement(offsetParent);\n var offsetParentIsScaled = isHTMLElement(offsetParent) && isElementScaled(offsetParent);\n var documentElement = getDocumentElement(offsetParent);\n var rect = getBoundingClientRect(elementOrVirtualElement, offsetParentIsScaled, isFixed);\n var scroll = {\n scrollLeft: 0,\n scrollTop: 0\n };\n var offsets = {\n x: 0,\n y: 0\n };\n\n if (isOffsetParentAnElement || !isOffsetParentAnElement && !isFixed) {\n if (getNodeName(offsetParent) !== 'body' || // https://github.com/popperjs/popper-core/issues/1078\n isScrollParent(documentElement)) {\n scroll = getNodeScroll(offsetParent);\n }\n\n if (isHTMLElement(offsetParent)) {\n offsets = getBoundingClientRect(offsetParent, true);\n offsets.x += offsetParent.clientLeft;\n offsets.y += offsetParent.clientTop;\n } else if (documentElement) {\n offsets.x = getWindowScrollBarX(documentElement);\n }\n }\n\n return {\n x: rect.left + scroll.scrollLeft - offsets.x,\n y: rect.top + scroll.scrollTop - offsets.y,\n width: rect.width,\n height: rect.height\n };\n}","import getWindowScroll from \"./getWindowScroll.js\";\nimport getWindow from \"./getWindow.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getHTMLElementScroll from \"./getHTMLElementScroll.js\";\nexport default function getNodeScroll(node) {\n if (node === getWindow(node) || !isHTMLElement(node)) {\n return getWindowScroll(node);\n } else {\n return getHTMLElementScroll(node);\n }\n}","export default function getHTMLElementScroll(element) {\n return {\n scrollLeft: element.scrollLeft,\n scrollTop: element.scrollTop\n };\n}","import { modifierPhases } from \"../enums.js\"; // source: https://stackoverflow.com/questions/49875255\n\nfunction order(modifiers) {\n var map = new Map();\n var visited = new Set();\n var result = [];\n modifiers.forEach(function (modifier) {\n map.set(modifier.name, modifier);\n }); // On visiting object, check for its dependencies and visit them recursively\n\n function sort(modifier) {\n visited.add(modifier.name);\n var requires = [].concat(modifier.requires || [], modifier.requiresIfExists || []);\n requires.forEach(function (dep) {\n if (!visited.has(dep)) {\n var depModifier = map.get(dep);\n\n if (depModifier) {\n sort(depModifier);\n }\n }\n });\n result.push(modifier);\n }\n\n modifiers.forEach(function (modifier) {\n if (!visited.has(modifier.name)) {\n // check for visited object\n sort(modifier);\n }\n });\n return result;\n}\n\nexport default function orderModifiers(modifiers) {\n // order based on dependencies\n var orderedModifiers = order(modifiers); // order based on phase\n\n return modifierPhases.reduce(function (acc, phase) {\n return acc.concat(orderedModifiers.filter(function (modifier) {\n return modifier.phase === phase;\n }));\n }, []);\n}","import getCompositeRect from \"./dom-utils/getCompositeRect.js\";\nimport getLayoutRect from \"./dom-utils/getLayoutRect.js\";\nimport listScrollParents from \"./dom-utils/listScrollParents.js\";\nimport getOffsetParent from \"./dom-utils/getOffsetParent.js\";\nimport orderModifiers from \"./utils/orderModifiers.js\";\nimport debounce from \"./utils/debounce.js\";\nimport mergeByName from \"./utils/mergeByName.js\";\nimport detectOverflow from \"./utils/detectOverflow.js\";\nimport { isElement } from \"./dom-utils/instanceOf.js\";\nvar DEFAULT_OPTIONS = {\n placement: 'bottom',\n modifiers: [],\n strategy: 'absolute'\n};\n\nfunction areValidElements() {\n for (var _len = arguments.length, args = new Array(_len), _key = 0; _key < _len; _key++) {\n args[_key] = arguments[_key];\n }\n\n return !args.some(function (element) {\n return !(element && typeof element.getBoundingClientRect === 'function');\n });\n}\n\nexport function popperGenerator(generatorOptions) {\n if (generatorOptions === void 0) {\n generatorOptions = {};\n }\n\n var _generatorOptions = generatorOptions,\n _generatorOptions$def = _generatorOptions.defaultModifiers,\n defaultModifiers = _generatorOptions$def === void 0 ? [] : _generatorOptions$def,\n _generatorOptions$def2 = _generatorOptions.defaultOptions,\n defaultOptions = _generatorOptions$def2 === void 0 ? DEFAULT_OPTIONS : _generatorOptions$def2;\n return function createPopper(reference, popper, options) {\n if (options === void 0) {\n options = defaultOptions;\n }\n\n var state = {\n placement: 'bottom',\n orderedModifiers: [],\n options: Object.assign({}, DEFAULT_OPTIONS, defaultOptions),\n modifiersData: {},\n elements: {\n reference: reference,\n popper: popper\n },\n attributes: {},\n styles: {}\n };\n var effectCleanupFns = [];\n var isDestroyed = false;\n var instance = {\n state: state,\n setOptions: function setOptions(setOptionsAction) {\n var options = typeof setOptionsAction === 'function' ? setOptionsAction(state.options) : setOptionsAction;\n cleanupModifierEffects();\n state.options = Object.assign({}, defaultOptions, state.options, options);\n state.scrollParents = {\n reference: isElement(reference) ? listScrollParents(reference) : reference.contextElement ? listScrollParents(reference.contextElement) : [],\n popper: listScrollParents(popper)\n }; // Orders the modifiers based on their dependencies and `phase`\n // properties\n\n var orderedModifiers = orderModifiers(mergeByName([].concat(defaultModifiers, state.options.modifiers))); // Strip out disabled modifiers\n\n state.orderedModifiers = orderedModifiers.filter(function (m) {\n return m.enabled;\n });\n runModifierEffects();\n return instance.update();\n },\n // Sync update – it will always be executed, even if not necessary. This\n // is useful for low frequency updates where sync behavior simplifies the\n // logic.\n // For high frequency updates (e.g. `resize` and `scroll` events), always\n // prefer the async Popper#update method\n forceUpdate: function forceUpdate() {\n if (isDestroyed) {\n return;\n }\n\n var _state$elements = state.elements,\n reference = _state$elements.reference,\n popper = _state$elements.popper; // Don't proceed if `reference` or `popper` are not valid elements\n // anymore\n\n if (!areValidElements(reference, popper)) {\n return;\n } // Store the reference and popper rects to be read by modifiers\n\n\n state.rects = {\n reference: getCompositeRect(reference, getOffsetParent(popper), state.options.strategy === 'fixed'),\n popper: getLayoutRect(popper)\n }; // Modifiers have the ability to reset the current update cycle. The\n // most common use case for this is the `flip` modifier changing the\n // placement, which then needs to re-run all the modifiers, because the\n // logic was previously ran for the previous placement and is therefore\n // stale/incorrect\n\n state.reset = false;\n state.placement = state.options.placement; // On each update cycle, the `modifiersData` property for each modifier\n // is filled with the initial data specified by the modifier. This means\n // it doesn't persist and is fresh on each update.\n // To ensure persistent data, use `${name}#persistent`\n\n state.orderedModifiers.forEach(function (modifier) {\n return state.modifiersData[modifier.name] = Object.assign({}, modifier.data);\n });\n\n for (var index = 0; index < state.orderedModifiers.length; index++) {\n if (state.reset === true) {\n state.reset = false;\n index = -1;\n continue;\n }\n\n var _state$orderedModifie = state.orderedModifiers[index],\n fn = _state$orderedModifie.fn,\n _state$orderedModifie2 = _state$orderedModifie.options,\n _options = _state$orderedModifie2 === void 0 ? {} : _state$orderedModifie2,\n name = _state$orderedModifie.name;\n\n if (typeof fn === 'function') {\n state = fn({\n state: state,\n options: _options,\n name: name,\n instance: instance\n }) || state;\n }\n }\n },\n // Async and optimistically optimized update – it will not be executed if\n // not necessary (debounced to run at most once-per-tick)\n update: debounce(function () {\n return new Promise(function (resolve) {\n instance.forceUpdate();\n resolve(state);\n });\n }),\n destroy: function destroy() {\n cleanupModifierEffects();\n isDestroyed = true;\n }\n };\n\n if (!areValidElements(reference, popper)) {\n return instance;\n }\n\n instance.setOptions(options).then(function (state) {\n if (!isDestroyed && options.onFirstUpdate) {\n options.onFirstUpdate(state);\n }\n }); // Modifiers have the ability to execute arbitrary code before the first\n // update cycle runs. They will be executed in the same order as the update\n // cycle. This is useful when a modifier adds some persistent data that\n // other modifiers need to use, but the modifier is run after the dependent\n // one.\n\n function runModifierEffects() {\n state.orderedModifiers.forEach(function (_ref) {\n var name = _ref.name,\n _ref$options = _ref.options,\n options = _ref$options === void 0 ? {} : _ref$options,\n effect = _ref.effect;\n\n if (typeof effect === 'function') {\n var cleanupFn = effect({\n state: state,\n name: name,\n instance: instance,\n options: options\n });\n\n var noopFn = function noopFn() {};\n\n effectCleanupFns.push(cleanupFn || noopFn);\n }\n });\n }\n\n function cleanupModifierEffects() {\n effectCleanupFns.forEach(function (fn) {\n return fn();\n });\n effectCleanupFns = [];\n }\n\n return instance;\n };\n}\nexport var createPopper = /*#__PURE__*/popperGenerator(); // eslint-disable-next-line import/no-unused-modules\n\nexport { detectOverflow };","export default function debounce(fn) {\n var pending;\n return function () {\n if (!pending) {\n pending = new Promise(function (resolve) {\n Promise.resolve().then(function () {\n pending = undefined;\n resolve(fn());\n });\n });\n }\n\n return pending;\n };\n}","export default function mergeByName(modifiers) {\n var merged = modifiers.reduce(function (merged, current) {\n var existing = merged[current.name];\n merged[current.name] = existing ? Object.assign({}, existing, current, {\n options: Object.assign({}, existing.options, current.options),\n data: Object.assign({}, existing.data, current.data)\n }) : current;\n return merged;\n }, {}); // IE11 does not support Object.values\n\n return Object.keys(merged).map(function (key) {\n return merged[key];\n });\n}","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles];\nvar createPopper = /*#__PURE__*/popperGenerator({\n defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow };","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nimport offset from \"./modifiers/offset.js\";\nimport flip from \"./modifiers/flip.js\";\nimport preventOverflow from \"./modifiers/preventOverflow.js\";\nimport arrow from \"./modifiers/arrow.js\";\nimport hide from \"./modifiers/hide.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles, offset, flip, preventOverflow, arrow, hide];\nvar createPopper = /*#__PURE__*/popperGenerator({\n defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow }; // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper as createPopperLite } from \"./popper-lite.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport * from \"./modifiers/index.js\";","/**\n * --------------------------------------------------------------------------\n * Bootstrap dropdown.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n defineJQueryPlugin,\n execute,\n getElement,\n getNextActiveElement,\n isDisabled,\n isElement,\n isRTL,\n isVisible,\n noop\n} from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'dropdown'\nconst DATA_KEY = 'bs.dropdown'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ESCAPE_KEY = 'Escape'\nconst TAB_KEY = 'Tab'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst RIGHT_MOUSE_BUTTON = 2 // MouseEvent.button value for the secondary button, usually the right button\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DATA_API = `keydown${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYUP_DATA_API = `keyup${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_DROPUP = 'dropup'\nconst CLASS_NAME_DROPEND = 'dropend'\nconst CLASS_NAME_DROPSTART = 'dropstart'\nconst CLASS_NAME_DROPUP_CENTER = 'dropup-center'\nconst CLASS_NAME_DROPDOWN_CENTER = 'dropdown-center'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"dropdown\"]:not(.disabled):not(:disabled)'\nconst SELECTOR_DATA_TOGGLE_SHOWN = `${SELECTOR_DATA_TOGGLE}.${CLASS_NAME_SHOW}`\nconst SELECTOR_MENU = '.dropdown-menu'\nconst SELECTOR_NAVBAR = '.navbar'\nconst SELECTOR_NAVBAR_NAV = '.navbar-nav'\nconst SELECTOR_VISIBLE_ITEMS = '.dropdown-menu .dropdown-item:not(.disabled):not(:disabled)'\n\nconst PLACEMENT_TOP = isRTL() ? 'top-end' : 'top-start'\nconst PLACEMENT_TOPEND = isRTL() ? 'top-start' : 'top-end'\nconst PLACEMENT_BOTTOM = isRTL() ? 'bottom-end' : 'bottom-start'\nconst PLACEMENT_BOTTOMEND = isRTL() ? 'bottom-start' : 'bottom-end'\nconst PLACEMENT_RIGHT = isRTL() ? 'left-start' : 'right-start'\nconst PLACEMENT_LEFT = isRTL() ? 'right-start' : 'left-start'\nconst PLACEMENT_TOPCENTER = 'top'\nconst PLACEMENT_BOTTOMCENTER = 'bottom'\n\nconst Default = {\n autoClose: true,\n boundary: 'clippingParents',\n display: 'dynamic',\n offset: [0, 2],\n popperConfig: null,\n reference: 'toggle'\n}\n\nconst DefaultType = {\n autoClose: '(boolean|string)',\n boundary: '(string|element)',\n display: 'string',\n offset: '(array|string|function)',\n popperConfig: '(null|object|function)',\n reference: '(string|element|object)'\n}\n\n/**\n * Class definition\n */\n\nclass Dropdown extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._popper = null\n this._parent = this._element.parentNode // dropdown wrapper\n // TODO: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.3/forms/input-group/\n this._menu = SelectorEngine.next(this._element, SELECTOR_MENU)[0] ||\n SelectorEngine.prev(this._element, SELECTOR_MENU)[0] ||\n SelectorEngine.findOne(SELECTOR_MENU, this._parent)\n this._inNavbar = this._detectNavbar()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle() {\n return this._isShown() ? this.hide() : this.show()\n }\n\n show() {\n if (isDisabled(this._element) || this._isShown()) {\n return\n }\n\n const relatedTarget = {\n relatedTarget: this._element\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, relatedTarget)\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._createPopper()\n\n // If this is a touch-enabled device we add extra\n // empty mouseover listeners to the body's immediate children;\n // only needed because of broken event delegation on iOS\n // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n if ('ontouchstart' in document.documentElement && !this._parent.closest(SELECTOR_NAVBAR_NAV)) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.on(element, 'mouseover', noop)\n }\n }\n\n this._element.focus()\n this._element.setAttribute('aria-expanded', true)\n\n this._menu.classList.add(CLASS_NAME_SHOW)\n this._element.classList.add(CLASS_NAME_SHOW)\n EventHandler.trigger(this._element, EVENT_SHOWN, relatedTarget)\n }\n\n hide() {\n if (isDisabled(this._element) || !this._isShown()) {\n return\n }\n\n const relatedTarget = {\n relatedTarget: this._element\n }\n\n this._completeHide(relatedTarget)\n }\n\n dispose() {\n if (this._popper) {\n this._popper.destroy()\n }\n\n super.dispose()\n }\n\n update() {\n this._inNavbar = this._detectNavbar()\n if (this._popper) {\n this._popper.update()\n }\n }\n\n // Private\n _completeHide(relatedTarget) {\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE, relatedTarget)\n if (hideEvent.defaultPrevented) {\n return\n }\n\n // If this is a touch-enabled device we remove the extra\n // empty mouseover listeners we added for iOS support\n if ('ontouchstart' in document.documentElement) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.off(element, 'mouseover', noop)\n }\n }\n\n if (this._popper) {\n this._popper.destroy()\n }\n\n this._menu.classList.remove(CLASS_NAME_SHOW)\n this._element.classList.remove(CLASS_NAME_SHOW)\n this._element.setAttribute('aria-expanded', 'false')\n Manipulator.removeDataAttribute(this._menu, 'popper')\n EventHandler.trigger(this._element, EVENT_HIDDEN, relatedTarget)\n }\n\n _getConfig(config) {\n config = super._getConfig(config)\n\n if (typeof config.reference === 'object' && !isElement(config.reference) &&\n typeof config.reference.getBoundingClientRect !== 'function'\n ) {\n // Popper virtual elements require a getBoundingClientRect method\n throw new TypeError(`${NAME.toUpperCase()}: Option \"reference\" provided type \"object\" without a required \"getBoundingClientRect\" method.`)\n }\n\n return config\n }\n\n _createPopper() {\n if (typeof Popper === 'undefined') {\n throw new TypeError('Bootstrap\\'s dropdowns require Popper (https://popper.js.org)')\n }\n\n let referenceElement = this._element\n\n if (this._config.reference === 'parent') {\n referenceElement = this._parent\n } else if (isElement(this._config.reference)) {\n referenceElement = getElement(this._config.reference)\n } else if (typeof this._config.reference === 'object') {\n referenceElement = this._config.reference\n }\n\n const popperConfig = this._getPopperConfig()\n this._popper = Popper.createPopper(referenceElement, this._menu, popperConfig)\n }\n\n _isShown() {\n return this._menu.classList.contains(CLASS_NAME_SHOW)\n }\n\n _getPlacement() {\n const parentDropdown = this._parent\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPEND)) {\n return PLACEMENT_RIGHT\n }\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPSTART)) {\n return PLACEMENT_LEFT\n }\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPUP_CENTER)) {\n return PLACEMENT_TOPCENTER\n }\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPDOWN_CENTER)) {\n return PLACEMENT_BOTTOMCENTER\n }\n\n // We need to trim the value because custom properties can also include spaces\n const isEnd = getComputedStyle(this._menu).getPropertyValue('--bs-position').trim() === 'end'\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPUP)) {\n return isEnd ? PLACEMENT_TOPEND : PLACEMENT_TOP\n }\n\n return isEnd ? PLACEMENT_BOTTOMEND : PLACEMENT_BOTTOM\n }\n\n _detectNavbar() {\n return this._element.closest(SELECTOR_NAVBAR) !== null\n }\n\n _getOffset() {\n const { offset } = this._config\n\n if (typeof offset === 'string') {\n return offset.split(',').map(value => Number.parseInt(value, 10))\n }\n\n if (typeof offset === 'function') {\n return popperData => offset(popperData, this._element)\n }\n\n return offset\n }\n\n _getPopperConfig() {\n const defaultBsPopperConfig = {\n placement: this._getPlacement(),\n modifiers: [{\n name: 'preventOverflow',\n options: {\n boundary: this._config.boundary\n }\n },\n {\n name: 'offset',\n options: {\n offset: this._getOffset()\n }\n }]\n }\n\n // Disable Popper if we have a static display or Dropdown is in Navbar\n if (this._inNavbar || this._config.display === 'static') {\n Manipulator.setDataAttribute(this._menu, 'popper', 'static') // TODO: v6 remove\n defaultBsPopperConfig.modifiers = [{\n name: 'applyStyles',\n enabled: false\n }]\n }\n\n return {\n ...defaultBsPopperConfig,\n ...execute(this._config.popperConfig, [defaultBsPopperConfig])\n }\n }\n\n _selectMenuItem({ key, target }) {\n const items = SelectorEngine.find(SELECTOR_VISIBLE_ITEMS, this._menu).filter(element => isVisible(element))\n\n if (!items.length) {\n return\n }\n\n // if target isn't included in items (e.g. when expanding the dropdown)\n // allow cycling to get the last item in case key equals ARROW_UP_KEY\n getNextActiveElement(items, target, key === ARROW_DOWN_KEY, !items.includes(target)).focus()\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Dropdown.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n })\n }\n\n static clearMenus(event) {\n if (event.button === RIGHT_MOUSE_BUTTON || (event.type === 'keyup' && event.key !== TAB_KEY)) {\n return\n }\n\n const openToggles = SelectorEngine.find(SELECTOR_DATA_TOGGLE_SHOWN)\n\n for (const toggle of openToggles) {\n const context = Dropdown.getInstance(toggle)\n if (!context || context._config.autoClose === false) {\n continue\n }\n\n const composedPath = event.composedPath()\n const isMenuTarget = composedPath.includes(context._menu)\n if (\n composedPath.includes(context._element) ||\n (context._config.autoClose === 'inside' && !isMenuTarget) ||\n (context._config.autoClose === 'outside' && isMenuTarget)\n ) {\n continue\n }\n\n // Tab navigation through the dropdown menu or events from contained inputs shouldn't close the menu\n if (context._menu.contains(event.target) && ((event.type === 'keyup' && event.key === TAB_KEY) || /input|select|option|textarea|form/i.test(event.target.tagName))) {\n continue\n }\n\n const relatedTarget = { relatedTarget: context._element }\n\n if (event.type === 'click') {\n relatedTarget.clickEvent = event\n }\n\n context._completeHide(relatedTarget)\n }\n }\n\n static dataApiKeydownHandler(event) {\n // If not an UP | DOWN | ESCAPE key => not a dropdown command\n // If input/textarea && if key is other than ESCAPE => not a dropdown command\n\n const isInput = /input|textarea/i.test(event.target.tagName)\n const isEscapeEvent = event.key === ESCAPE_KEY\n const isUpOrDownEvent = [ARROW_UP_KEY, ARROW_DOWN_KEY].includes(event.key)\n\n if (!isUpOrDownEvent && !isEscapeEvent) {\n return\n }\n\n if (isInput && !isEscapeEvent) {\n return\n }\n\n event.preventDefault()\n\n // TODO: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.3/forms/input-group/\n const getToggleButton = this.matches(SELECTOR_DATA_TOGGLE) ?\n this :\n (SelectorEngine.prev(this, SELECTOR_DATA_TOGGLE)[0] ||\n SelectorEngine.next(this, SELECTOR_DATA_TOGGLE)[0] ||\n SelectorEngine.findOne(SELECTOR_DATA_TOGGLE, event.delegateTarget.parentNode))\n\n const instance = Dropdown.getOrCreateInstance(getToggleButton)\n\n if (isUpOrDownEvent) {\n event.stopPropagation()\n instance.show()\n instance._selectMenuItem(event)\n return\n }\n\n if (instance._isShown()) { // else is escape and we check if it is shown\n event.stopPropagation()\n instance.hide()\n getToggleButton.focus()\n }\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_DATA_TOGGLE, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_MENU, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_CLICK_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_KEYUP_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n event.preventDefault()\n Dropdown.getOrCreateInstance(this).toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Dropdown)\n\nexport default Dropdown\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/backdrop.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport Config from './config.js'\nimport { execute, executeAfterTransition, getElement, reflow } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'backdrop'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst EVENT_MOUSEDOWN = `mousedown.bs.${NAME}`\n\nconst Default = {\n className: 'modal-backdrop',\n clickCallback: null,\n isAnimated: false,\n isVisible: true, // if false, we use the backdrop helper without adding any element to the dom\n rootElement: 'body' // give the choice to place backdrop under different elements\n}\n\nconst DefaultType = {\n className: 'string',\n clickCallback: '(function|null)',\n isAnimated: 'boolean',\n isVisible: 'boolean',\n rootElement: '(element|string)'\n}\n\n/**\n * Class definition\n */\n\nclass Backdrop extends Config {\n constructor(config) {\n super()\n this._config = this._getConfig(config)\n this._isAppended = false\n this._element = null\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n show(callback) {\n if (!this._config.isVisible) {\n execute(callback)\n return\n }\n\n this._append()\n\n const element = this._getElement()\n if (this._config.isAnimated) {\n reflow(element)\n }\n\n element.classList.add(CLASS_NAME_SHOW)\n\n this._emulateAnimation(() => {\n execute(callback)\n })\n }\n\n hide(callback) {\n if (!this._config.isVisible) {\n execute(callback)\n return\n }\n\n this._getElement().classList.remove(CLASS_NAME_SHOW)\n\n this._emulateAnimation(() => {\n this.dispose()\n execute(callback)\n })\n }\n\n dispose() {\n if (!this._isAppended) {\n return\n }\n\n EventHandler.off(this._element, EVENT_MOUSEDOWN)\n\n this._element.remove()\n this._isAppended = false\n }\n\n // Private\n _getElement() {\n if (!this._element) {\n const backdrop = document.createElement('div')\n backdrop.className = this._config.className\n if (this._config.isAnimated) {\n backdrop.classList.add(CLASS_NAME_FADE)\n }\n\n this._element = backdrop\n }\n\n return this._element\n }\n\n _configAfterMerge(config) {\n // use getElement() with the default \"body\" to get a fresh Element on each instantiation\n config.rootElement = getElement(config.rootElement)\n return config\n }\n\n _append() {\n if (this._isAppended) {\n return\n }\n\n const element = this._getElement()\n this._config.rootElement.append(element)\n\n EventHandler.on(element, EVENT_MOUSEDOWN, () => {\n execute(this._config.clickCallback)\n })\n\n this._isAppended = true\n }\n\n _emulateAnimation(callback) {\n executeAfterTransition(callback, this._getElement(), this._config.isAnimated)\n }\n}\n\nexport default Backdrop\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/focustrap.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport Config from './config.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'focustrap'\nconst DATA_KEY = 'bs.focustrap'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_KEYDOWN_TAB = `keydown.tab${EVENT_KEY}`\n\nconst TAB_KEY = 'Tab'\nconst TAB_NAV_FORWARD = 'forward'\nconst TAB_NAV_BACKWARD = 'backward'\n\nconst Default = {\n autofocus: true,\n trapElement: null // The element to trap focus inside of\n}\n\nconst DefaultType = {\n autofocus: 'boolean',\n trapElement: 'element'\n}\n\n/**\n * Class definition\n */\n\nclass FocusTrap extends Config {\n constructor(config) {\n super()\n this._config = this._getConfig(config)\n this._isActive = false\n this._lastTabNavDirection = null\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n activate() {\n if (this._isActive) {\n return\n }\n\n if (this._config.autofocus) {\n this._config.trapElement.focus()\n }\n\n EventHandler.off(document, EVENT_KEY) // guard against infinite focus loop\n EventHandler.on(document, EVENT_FOCUSIN, event => this._handleFocusin(event))\n EventHandler.on(document, EVENT_KEYDOWN_TAB, event => this._handleKeydown(event))\n\n this._isActive = true\n }\n\n deactivate() {\n if (!this._isActive) {\n return\n }\n\n this._isActive = false\n EventHandler.off(document, EVENT_KEY)\n }\n\n // Private\n _handleFocusin(event) {\n const { trapElement } = this._config\n\n if (event.target === document || event.target === trapElement || trapElement.contains(event.target)) {\n return\n }\n\n const elements = SelectorEngine.focusableChildren(trapElement)\n\n if (elements.length === 0) {\n trapElement.focus()\n } else if (this._lastTabNavDirection === TAB_NAV_BACKWARD) {\n elements[elements.length - 1].focus()\n } else {\n elements[0].focus()\n }\n }\n\n _handleKeydown(event) {\n if (event.key !== TAB_KEY) {\n return\n }\n\n this._lastTabNavDirection = event.shiftKey ? TAB_NAV_BACKWARD : TAB_NAV_FORWARD\n }\n}\n\nexport default FocusTrap\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/scrollBar.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Manipulator from '../dom/manipulator.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport { isElement } from './index.js'\n\n/**\n * Constants\n */\n\nconst SELECTOR_FIXED_CONTENT = '.fixed-top, .fixed-bottom, .is-fixed, .sticky-top'\nconst SELECTOR_STICKY_CONTENT = '.sticky-top'\nconst PROPERTY_PADDING = 'padding-right'\nconst PROPERTY_MARGIN = 'margin-right'\n\n/**\n * Class definition\n */\n\nclass ScrollBarHelper {\n constructor() {\n this._element = document.body\n }\n\n // Public\n getWidth() {\n // https://developer.mozilla.org/en-US/docs/Web/API/Window/innerWidth#usage_notes\n const documentWidth = document.documentElement.clientWidth\n return Math.abs(window.innerWidth - documentWidth)\n }\n\n hide() {\n const width = this.getWidth()\n this._disableOverFlow()\n // give padding to element to balance the hidden scrollbar width\n this._setElementAttributes(this._element, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n // trick: We adjust positive paddingRight and negative marginRight to sticky-top elements to keep showing fullwidth\n this._setElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n this._setElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN, calculatedValue => calculatedValue - width)\n }\n\n reset() {\n this._resetElementAttributes(this._element, 'overflow')\n this._resetElementAttributes(this._element, PROPERTY_PADDING)\n this._resetElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING)\n this._resetElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN)\n }\n\n isOverflowing() {\n return this.getWidth() > 0\n }\n\n // Private\n _disableOverFlow() {\n this._saveInitialAttribute(this._element, 'overflow')\n this._element.style.overflow = 'hidden'\n }\n\n _setElementAttributes(selector, styleProperty, callback) {\n const scrollbarWidth = this.getWidth()\n const manipulationCallBack = element => {\n if (element !== this._element && window.innerWidth > element.clientWidth + scrollbarWidth) {\n return\n }\n\n this._saveInitialAttribute(element, styleProperty)\n const calculatedValue = window.getComputedStyle(element).getPropertyValue(styleProperty)\n element.style.setProperty(styleProperty, `${callback(Number.parseFloat(calculatedValue))}px`)\n }\n\n this._applyManipulationCallback(selector, manipulationCallBack)\n }\n\n _saveInitialAttribute(element, styleProperty) {\n const actualValue = element.style.getPropertyValue(styleProperty)\n if (actualValue) {\n Manipulator.setDataAttribute(element, styleProperty, actualValue)\n }\n }\n\n _resetElementAttributes(selector, styleProperty) {\n const manipulationCallBack = element => {\n const value = Manipulator.getDataAttribute(element, styleProperty)\n // We only want to remove the property if the value is `null`; the value can also be zero\n if (value === null) {\n element.style.removeProperty(styleProperty)\n return\n }\n\n Manipulator.removeDataAttribute(element, styleProperty)\n element.style.setProperty(styleProperty, value)\n }\n\n this._applyManipulationCallback(selector, manipulationCallBack)\n }\n\n _applyManipulationCallback(selector, callBack) {\n if (isElement(selector)) {\n callBack(selector)\n return\n }\n\n for (const sel of SelectorEngine.find(selector, this._element)) {\n callBack(sel)\n }\n }\n}\n\nexport default ScrollBarHelper\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap modal.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport Backdrop from './util/backdrop.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport FocusTrap from './util/focustrap.js'\nimport { defineJQueryPlugin, isRTL, isVisible, reflow } from './util/index.js'\nimport ScrollBarHelper from './util/scrollbar.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'modal'\nconst DATA_KEY = 'bs.modal'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst ESCAPE_KEY = 'Escape'\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DISMISS = `click.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEDOWN_DISMISS = `mousedown.dismiss${EVENT_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_OPEN = 'modal-open'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_STATIC = 'modal-static'\n\nconst OPEN_SELECTOR = '.modal.show'\nconst SELECTOR_DIALOG = '.modal-dialog'\nconst SELECTOR_MODAL_BODY = '.modal-body'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"modal\"]'\n\nconst Default = {\n backdrop: true,\n focus: true,\n keyboard: true\n}\n\nconst DefaultType = {\n backdrop: '(boolean|string)',\n focus: 'boolean',\n keyboard: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Modal extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._dialog = SelectorEngine.findOne(SELECTOR_DIALOG, this._element)\n this._backdrop = this._initializeBackDrop()\n this._focustrap = this._initializeFocusTrap()\n this._isShown = false\n this._isTransitioning = false\n this._scrollBar = new ScrollBarHelper()\n\n this._addEventListeners()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle(relatedTarget) {\n return this._isShown ? this.hide() : this.show(relatedTarget)\n }\n\n show(relatedTarget) {\n if (this._isShown || this._isTransitioning) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, {\n relatedTarget\n })\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._isShown = true\n this._isTransitioning = true\n\n this._scrollBar.hide()\n\n document.body.classList.add(CLASS_NAME_OPEN)\n\n this._adjustDialog()\n\n this._backdrop.show(() => this._showElement(relatedTarget))\n }\n\n hide() {\n if (!this._isShown || this._isTransitioning) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n if (hideEvent.defaultPrevented) {\n return\n }\n\n this._isShown = false\n this._isTransitioning = true\n this._focustrap.deactivate()\n\n this._element.classList.remove(CLASS_NAME_SHOW)\n\n this._queueCallback(() => this._hideModal(), this._element, this._isAnimated())\n }\n\n dispose() {\n EventHandler.off(window, EVENT_KEY)\n EventHandler.off(this._dialog, EVENT_KEY)\n\n this._backdrop.dispose()\n this._focustrap.deactivate()\n\n super.dispose()\n }\n\n handleUpdate() {\n this._adjustDialog()\n }\n\n // Private\n _initializeBackDrop() {\n return new Backdrop({\n isVisible: Boolean(this._config.backdrop), // 'static' option will be translated to true, and booleans will keep their value,\n isAnimated: this._isAnimated()\n })\n }\n\n _initializeFocusTrap() {\n return new FocusTrap({\n trapElement: this._element\n })\n }\n\n _showElement(relatedTarget) {\n // try to append dynamic modal\n if (!document.body.contains(this._element)) {\n document.body.append(this._element)\n }\n\n this._element.style.display = 'block'\n this._element.removeAttribute('aria-hidden')\n this._element.setAttribute('aria-modal', true)\n this._element.setAttribute('role', 'dialog')\n this._element.scrollTop = 0\n\n const modalBody = SelectorEngine.findOne(SELECTOR_MODAL_BODY, this._dialog)\n if (modalBody) {\n modalBody.scrollTop = 0\n }\n\n reflow(this._element)\n\n this._element.classList.add(CLASS_NAME_SHOW)\n\n const transitionComplete = () => {\n if (this._config.focus) {\n this._focustrap.activate()\n }\n\n this._isTransitioning = false\n EventHandler.trigger(this._element, EVENT_SHOWN, {\n relatedTarget\n })\n }\n\n this._queueCallback(transitionComplete, this._dialog, this._isAnimated())\n }\n\n _addEventListeners() {\n EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n if (event.key !== ESCAPE_KEY) {\n return\n }\n\n if (this._config.keyboard) {\n this.hide()\n return\n }\n\n this._triggerBackdropTransition()\n })\n\n EventHandler.on(window, EVENT_RESIZE, () => {\n if (this._isShown && !this._isTransitioning) {\n this._adjustDialog()\n }\n })\n\n EventHandler.on(this._element, EVENT_MOUSEDOWN_DISMISS, event => {\n // a bad trick to segregate clicks that may start inside dialog but end outside, and avoid listen to scrollbar clicks\n EventHandler.one(this._element, EVENT_CLICK_DISMISS, event2 => {\n if (this._element !== event.target || this._element !== event2.target) {\n return\n }\n\n if (this._config.backdrop === 'static') {\n this._triggerBackdropTransition()\n return\n }\n\n if (this._config.backdrop) {\n this.hide()\n }\n })\n })\n }\n\n _hideModal() {\n this._element.style.display = 'none'\n this._element.setAttribute('aria-hidden', true)\n this._element.removeAttribute('aria-modal')\n this._element.removeAttribute('role')\n this._isTransitioning = false\n\n this._backdrop.hide(() => {\n document.body.classList.remove(CLASS_NAME_OPEN)\n this._resetAdjustments()\n this._scrollBar.reset()\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n })\n }\n\n _isAnimated() {\n return this._element.classList.contains(CLASS_NAME_FADE)\n }\n\n _triggerBackdropTransition() {\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n if (hideEvent.defaultPrevented) {\n return\n }\n\n const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n const initialOverflowY = this._element.style.overflowY\n // return if the following background transition hasn't yet completed\n if (initialOverflowY === 'hidden' || this._element.classList.contains(CLASS_NAME_STATIC)) {\n return\n }\n\n if (!isModalOverflowing) {\n this._element.style.overflowY = 'hidden'\n }\n\n this._element.classList.add(CLASS_NAME_STATIC)\n this._queueCallback(() => {\n this._element.classList.remove(CLASS_NAME_STATIC)\n this._queueCallback(() => {\n this._element.style.overflowY = initialOverflowY\n }, this._dialog)\n }, this._dialog)\n\n this._element.focus()\n }\n\n /**\n * The following methods are used to handle overflowing modals\n */\n\n _adjustDialog() {\n const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n const scrollbarWidth = this._scrollBar.getWidth()\n const isBodyOverflowing = scrollbarWidth > 0\n\n if (isBodyOverflowing && !isModalOverflowing) {\n const property = isRTL() ? 'paddingLeft' : 'paddingRight'\n this._element.style[property] = `${scrollbarWidth}px`\n }\n\n if (!isBodyOverflowing && isModalOverflowing) {\n const property = isRTL() ? 'paddingRight' : 'paddingLeft'\n this._element.style[property] = `${scrollbarWidth}px`\n }\n }\n\n _resetAdjustments() {\n this._element.style.paddingLeft = ''\n this._element.style.paddingRight = ''\n }\n\n // Static\n static jQueryInterface(config, relatedTarget) {\n return this.each(function () {\n const data = Modal.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](relatedTarget)\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n const target = SelectorEngine.getElementFromSelector(this)\n\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n EventHandler.one(target, EVENT_SHOW, showEvent => {\n if (showEvent.defaultPrevented) {\n // only register focus restorer if modal will actually get shown\n return\n }\n\n EventHandler.one(target, EVENT_HIDDEN, () => {\n if (isVisible(this)) {\n this.focus()\n }\n })\n })\n\n // avoid conflict when clicking modal toggler while another one is open\n const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n if (alreadyOpen) {\n Modal.getInstance(alreadyOpen).hide()\n }\n\n const data = Modal.getOrCreateInstance(target)\n\n data.toggle(this)\n})\n\nenableDismissTrigger(Modal)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Modal)\n\nexport default Modal\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap offcanvas.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport Backdrop from './util/backdrop.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport FocusTrap from './util/focustrap.js'\nimport {\n defineJQueryPlugin,\n isDisabled,\n isVisible\n} from './util/index.js'\nimport ScrollBarHelper from './util/scrollbar.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'offcanvas'\nconst DATA_KEY = 'bs.offcanvas'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst ESCAPE_KEY = 'Escape'\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_SHOWING = 'showing'\nconst CLASS_NAME_HIDING = 'hiding'\nconst CLASS_NAME_BACKDROP = 'offcanvas-backdrop'\nconst OPEN_SELECTOR = '.offcanvas.show'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"offcanvas\"]'\n\nconst Default = {\n backdrop: true,\n keyboard: true,\n scroll: false\n}\n\nconst DefaultType = {\n backdrop: '(boolean|string)',\n keyboard: 'boolean',\n scroll: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Offcanvas extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._isShown = false\n this._backdrop = this._initializeBackDrop()\n this._focustrap = this._initializeFocusTrap()\n this._addEventListeners()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle(relatedTarget) {\n return this._isShown ? this.hide() : this.show(relatedTarget)\n }\n\n show(relatedTarget) {\n if (this._isShown) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, { relatedTarget })\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._isShown = true\n this._backdrop.show()\n\n if (!this._config.scroll) {\n new ScrollBarHelper().hide()\n }\n\n this._element.setAttribute('aria-modal', true)\n this._element.setAttribute('role', 'dialog')\n this._element.classList.add(CLASS_NAME_SHOWING)\n\n const completeCallBack = () => {\n if (!this._config.scroll || this._config.backdrop) {\n this._focustrap.activate()\n }\n\n this._element.classList.add(CLASS_NAME_SHOW)\n this._element.classList.remove(CLASS_NAME_SHOWING)\n EventHandler.trigger(this._element, EVENT_SHOWN, { relatedTarget })\n }\n\n this._queueCallback(completeCallBack, this._element, true)\n }\n\n hide() {\n if (!this._isShown) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n if (hideEvent.defaultPrevented) {\n return\n }\n\n this._focustrap.deactivate()\n this._element.blur()\n this._isShown = false\n this._element.classList.add(CLASS_NAME_HIDING)\n this._backdrop.hide()\n\n const completeCallback = () => {\n this._element.classList.remove(CLASS_NAME_SHOW, CLASS_NAME_HIDING)\n this._element.removeAttribute('aria-modal')\n this._element.removeAttribute('role')\n\n if (!this._config.scroll) {\n new ScrollBarHelper().reset()\n }\n\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n }\n\n this._queueCallback(completeCallback, this._element, true)\n }\n\n dispose() {\n this._backdrop.dispose()\n this._focustrap.deactivate()\n super.dispose()\n }\n\n // Private\n _initializeBackDrop() {\n const clickCallback = () => {\n if (this._config.backdrop === 'static') {\n EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n return\n }\n\n this.hide()\n }\n\n // 'static' option will be translated to true, and booleans will keep their value\n const isVisible = Boolean(this._config.backdrop)\n\n return new Backdrop({\n className: CLASS_NAME_BACKDROP,\n isVisible,\n isAnimated: true,\n rootElement: this._element.parentNode,\n clickCallback: isVisible ? clickCallback : null\n })\n }\n\n _initializeFocusTrap() {\n return new FocusTrap({\n trapElement: this._element\n })\n }\n\n _addEventListeners() {\n EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n if (event.key !== ESCAPE_KEY) {\n return\n }\n\n if (this._config.keyboard) {\n this.hide()\n return\n }\n\n EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n })\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Offcanvas.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](this)\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n const target = SelectorEngine.getElementFromSelector(this)\n\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n if (isDisabled(this)) {\n return\n }\n\n EventHandler.one(target, EVENT_HIDDEN, () => {\n // focus on trigger when it is closed\n if (isVisible(this)) {\n this.focus()\n }\n })\n\n // avoid conflict when clicking a toggler of an offcanvas, while another is open\n const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n if (alreadyOpen && alreadyOpen !== target) {\n Offcanvas.getInstance(alreadyOpen).hide()\n }\n\n const data = Offcanvas.getOrCreateInstance(target)\n data.toggle(this)\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n for (const selector of SelectorEngine.find(OPEN_SELECTOR)) {\n Offcanvas.getOrCreateInstance(selector).show()\n }\n})\n\nEventHandler.on(window, EVENT_RESIZE, () => {\n for (const element of SelectorEngine.find('[aria-modal][class*=show][class*=offcanvas-]')) {\n if (getComputedStyle(element).position !== 'fixed') {\n Offcanvas.getOrCreateInstance(element).hide()\n }\n }\n})\n\nenableDismissTrigger(Offcanvas)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Offcanvas)\n\nexport default Offcanvas\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/sanitizer.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n// js-docs-start allow-list\nconst ARIA_ATTRIBUTE_PATTERN = /^aria-[\\w-]*$/i\n\nexport const DefaultAllowlist = {\n // Global attributes allowed on any supplied element below.\n '*': ['class', 'dir', 'id', 'lang', 'role', ARIA_ATTRIBUTE_PATTERN],\n a: ['target', 'href', 'title', 'rel'],\n area: [],\n b: [],\n br: [],\n col: [],\n code: [],\n div: [],\n em: [],\n hr: [],\n h1: [],\n h2: [],\n h3: [],\n h4: [],\n h5: [],\n h6: [],\n i: [],\n img: ['src', 'srcset', 'alt', 'title', 'width', 'height'],\n li: [],\n ol: [],\n p: [],\n pre: [],\n s: [],\n small: [],\n span: [],\n sub: [],\n sup: [],\n strong: [],\n u: [],\n ul: []\n}\n// js-docs-end allow-list\n\nconst uriAttributes = new Set([\n 'background',\n 'cite',\n 'href',\n 'itemtype',\n 'longdesc',\n 'poster',\n 'src',\n 'xlink:href'\n])\n\n/**\n * A pattern that recognizes URLs that are safe wrt. XSS in URL navigation\n * contexts.\n *\n * Shout-out to Angular https://github.com/angular/angular/blob/15.2.8/packages/core/src/sanitization/url_sanitizer.ts#L38\n */\n// eslint-disable-next-line unicorn/better-regex\nconst SAFE_URL_PATTERN = /^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i\n\nconst allowedAttribute = (attribute, allowedAttributeList) => {\n const attributeName = attribute.nodeName.toLowerCase()\n\n if (allowedAttributeList.includes(attributeName)) {\n if (uriAttributes.has(attributeName)) {\n return Boolean(SAFE_URL_PATTERN.test(attribute.nodeValue))\n }\n\n return true\n }\n\n // Check if a regular expression validates the attribute.\n return allowedAttributeList.filter(attributeRegex => attributeRegex instanceof RegExp)\n .some(regex => regex.test(attributeName))\n}\n\nexport function sanitizeHtml(unsafeHtml, allowList, sanitizeFunction) {\n if (!unsafeHtml.length) {\n return unsafeHtml\n }\n\n if (sanitizeFunction && typeof sanitizeFunction === 'function') {\n return sanitizeFunction(unsafeHtml)\n }\n\n const domParser = new window.DOMParser()\n const createdDocument = domParser.parseFromString(unsafeHtml, 'text/html')\n const elements = [].concat(...createdDocument.body.querySelectorAll('*'))\n\n for (const element of elements) {\n const elementName = element.nodeName.toLowerCase()\n\n if (!Object.keys(allowList).includes(elementName)) {\n element.remove()\n continue\n }\n\n const attributeList = [].concat(...element.attributes)\n const allowedAttributes = [].concat(allowList['*'] || [], allowList[elementName] || [])\n\n for (const attribute of attributeList) {\n if (!allowedAttribute(attribute, allowedAttributes)) {\n element.removeAttribute(attribute.nodeName)\n }\n }\n }\n\n return createdDocument.body.innerHTML\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/template-factory.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport SelectorEngine from '../dom/selector-engine.js'\nimport Config from './config.js'\nimport { DefaultAllowlist, sanitizeHtml } from './sanitizer.js'\nimport { execute, getElement, isElement } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'TemplateFactory'\n\nconst Default = {\n allowList: DefaultAllowlist,\n content: {}, // { selector : text , selector2 : text2 , }\n extraClass: '',\n html: false,\n sanitize: true,\n sanitizeFn: null,\n template: '
'\n}\n\nconst DefaultType = {\n allowList: 'object',\n content: 'object',\n extraClass: '(string|function)',\n html: 'boolean',\n sanitize: 'boolean',\n sanitizeFn: '(null|function)',\n template: 'string'\n}\n\nconst DefaultContentType = {\n entry: '(string|element|function|null)',\n selector: '(string|element)'\n}\n\n/**\n * Class definition\n */\n\nclass TemplateFactory extends Config {\n constructor(config) {\n super()\n this._config = this._getConfig(config)\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n getContent() {\n return Object.values(this._config.content)\n .map(config => this._resolvePossibleFunction(config))\n .filter(Boolean)\n }\n\n hasContent() {\n return this.getContent().length > 0\n }\n\n changeContent(content) {\n this._checkContent(content)\n this._config.content = { ...this._config.content, ...content }\n return this\n }\n\n toHtml() {\n const templateWrapper = document.createElement('div')\n templateWrapper.innerHTML = this._maybeSanitize(this._config.template)\n\n for (const [selector, text] of Object.entries(this._config.content)) {\n this._setContent(templateWrapper, text, selector)\n }\n\n const template = templateWrapper.children[0]\n const extraClass = this._resolvePossibleFunction(this._config.extraClass)\n\n if (extraClass) {\n template.classList.add(...extraClass.split(' '))\n }\n\n return template\n }\n\n // Private\n _typeCheckConfig(config) {\n super._typeCheckConfig(config)\n this._checkContent(config.content)\n }\n\n _checkContent(arg) {\n for (const [selector, content] of Object.entries(arg)) {\n super._typeCheckConfig({ selector, entry: content }, DefaultContentType)\n }\n }\n\n _setContent(template, content, selector) {\n const templateElement = SelectorEngine.findOne(selector, template)\n\n if (!templateElement) {\n return\n }\n\n content = this._resolvePossibleFunction(content)\n\n if (!content) {\n templateElement.remove()\n return\n }\n\n if (isElement(content)) {\n this._putElementInTemplate(getElement(content), templateElement)\n return\n }\n\n if (this._config.html) {\n templateElement.innerHTML = this._maybeSanitize(content)\n return\n }\n\n templateElement.textContent = content\n }\n\n _maybeSanitize(arg) {\n return this._config.sanitize ? sanitizeHtml(arg, this._config.allowList, this._config.sanitizeFn) : arg\n }\n\n _resolvePossibleFunction(arg) {\n return execute(arg, [this])\n }\n\n _putElementInTemplate(element, templateElement) {\n if (this._config.html) {\n templateElement.innerHTML = ''\n templateElement.append(element)\n return\n }\n\n templateElement.textContent = element.textContent\n }\n}\n\nexport default TemplateFactory\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap tooltip.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport { defineJQueryPlugin, execute, findShadowRoot, getElement, getUID, isRTL, noop } from './util/index.js'\nimport { DefaultAllowlist } from './util/sanitizer.js'\nimport TemplateFactory from './util/template-factory.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'tooltip'\nconst DISALLOWED_ATTRIBUTES = new Set(['sanitize', 'allowList', 'sanitizeFn'])\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_MODAL = 'modal'\nconst CLASS_NAME_SHOW = 'show'\n\nconst SELECTOR_TOOLTIP_INNER = '.tooltip-inner'\nconst SELECTOR_MODAL = `.${CLASS_NAME_MODAL}`\n\nconst EVENT_MODAL_HIDE = 'hide.bs.modal'\n\nconst TRIGGER_HOVER = 'hover'\nconst TRIGGER_FOCUS = 'focus'\nconst TRIGGER_CLICK = 'click'\nconst TRIGGER_MANUAL = 'manual'\n\nconst EVENT_HIDE = 'hide'\nconst EVENT_HIDDEN = 'hidden'\nconst EVENT_SHOW = 'show'\nconst EVENT_SHOWN = 'shown'\nconst EVENT_INSERTED = 'inserted'\nconst EVENT_CLICK = 'click'\nconst EVENT_FOCUSIN = 'focusin'\nconst EVENT_FOCUSOUT = 'focusout'\nconst EVENT_MOUSEENTER = 'mouseenter'\nconst EVENT_MOUSELEAVE = 'mouseleave'\n\nconst AttachmentMap = {\n AUTO: 'auto',\n TOP: 'top',\n RIGHT: isRTL() ? 'left' : 'right',\n BOTTOM: 'bottom',\n LEFT: isRTL() ? 'right' : 'left'\n}\n\nconst Default = {\n allowList: DefaultAllowlist,\n animation: true,\n boundary: 'clippingParents',\n container: false,\n customClass: '',\n delay: 0,\n fallbackPlacements: ['top', 'right', 'bottom', 'left'],\n html: false,\n offset: [0, 6],\n placement: 'top',\n popperConfig: null,\n sanitize: true,\n sanitizeFn: null,\n selector: false,\n template: '
' +\n '
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',\n title: '',\n trigger: 'hover focus'\n}\n\nconst DefaultType = {\n allowList: 'object',\n animation: 'boolean',\n boundary: '(string|element)',\n container: '(string|element|boolean)',\n customClass: '(string|function)',\n delay: '(number|object)',\n fallbackPlacements: 'array',\n html: 'boolean',\n offset: '(array|string|function)',\n placement: '(string|function)',\n popperConfig: '(null|object|function)',\n sanitize: 'boolean',\n sanitizeFn: '(null|function)',\n selector: '(string|boolean)',\n template: 'string',\n title: '(string|element|function)',\n trigger: 'string'\n}\n\n/**\n * Class definition\n */\n\nclass Tooltip extends BaseComponent {\n constructor(element, config) {\n if (typeof Popper === 'undefined') {\n throw new TypeError('Bootstrap\\'s tooltips require Popper (https://popper.js.org)')\n }\n\n super(element, config)\n\n // Private\n this._isEnabled = true\n this._timeout = 0\n this._isHovered = null\n this._activeTrigger = {}\n this._popper = null\n this._templateFactory = null\n this._newContent = null\n\n // Protected\n this.tip = null\n\n this._setListeners()\n\n if (!this._config.selector) {\n this._fixTitle()\n }\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n enable() {\n this._isEnabled = true\n }\n\n disable() {\n this._isEnabled = false\n }\n\n toggleEnabled() {\n this._isEnabled = !this._isEnabled\n }\n\n toggle() {\n if (!this._isEnabled) {\n return\n }\n\n this._activeTrigger.click = !this._activeTrigger.click\n if (this._isShown()) {\n this._leave()\n return\n }\n\n this._enter()\n }\n\n dispose() {\n clearTimeout(this._timeout)\n\n EventHandler.off(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n if (this._element.getAttribute('data-bs-original-title')) {\n this._element.setAttribute('title', this._element.getAttribute('data-bs-original-title'))\n }\n\n this._disposePopper()\n super.dispose()\n }\n\n show() {\n if (this._element.style.display === 'none') {\n throw new Error('Please use show on visible elements')\n }\n\n if (!(this._isWithContent() && this._isEnabled)) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOW))\n const shadowRoot = findShadowRoot(this._element)\n const isInTheDom = (shadowRoot || this._element.ownerDocument.documentElement).contains(this._element)\n\n if (showEvent.defaultPrevented || !isInTheDom) {\n return\n }\n\n // TODO: v6 remove this or make it optional\n this._disposePopper()\n\n const tip = this._getTipElement()\n\n this._element.setAttribute('aria-describedby', tip.getAttribute('id'))\n\n const { container } = this._config\n\n if (!this._element.ownerDocument.documentElement.contains(this.tip)) {\n container.append(tip)\n EventHandler.trigger(this._element, this.constructor.eventName(EVENT_INSERTED))\n }\n\n this._popper = this._createPopper(tip)\n\n tip.classList.add(CLASS_NAME_SHOW)\n\n // If this is a touch-enabled device we add extra\n // empty mouseover listeners to the body's immediate children;\n // only needed because of broken event delegation on iOS\n // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n if ('ontouchstart' in document.documentElement) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.on(element, 'mouseover', noop)\n }\n }\n\n const complete = () => {\n EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOWN))\n\n if (this._isHovered === false) {\n this._leave()\n }\n\n this._isHovered = false\n }\n\n this._queueCallback(complete, this.tip, this._isAnimated())\n }\n\n hide() {\n if (!this._isShown()) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDE))\n if (hideEvent.defaultPrevented) {\n return\n }\n\n const tip = this._getTipElement()\n tip.classList.remove(CLASS_NAME_SHOW)\n\n // If this is a touch-enabled device we remove the extra\n // empty mouseover listeners we added for iOS support\n if ('ontouchstart' in document.documentElement) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.off(element, 'mouseover', noop)\n }\n }\n\n this._activeTrigger[TRIGGER_CLICK] = false\n this._activeTrigger[TRIGGER_FOCUS] = false\n this._activeTrigger[TRIGGER_HOVER] = false\n this._isHovered = null // it is a trick to support manual triggering\n\n const complete = () => {\n if (this._isWithActiveTrigger()) {\n return\n }\n\n if (!this._isHovered) {\n this._disposePopper()\n }\n\n this._element.removeAttribute('aria-describedby')\n EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDDEN))\n }\n\n this._queueCallback(complete, this.tip, this._isAnimated())\n }\n\n update() {\n if (this._popper) {\n this._popper.update()\n }\n }\n\n // Protected\n _isWithContent() {\n return Boolean(this._getTitle())\n }\n\n _getTipElement() {\n if (!this.tip) {\n this.tip = this._createTipElement(this._newContent || this._getContentForTemplate())\n }\n\n return this.tip\n }\n\n _createTipElement(content) {\n const tip = this._getTemplateFactory(content).toHtml()\n\n // TODO: remove this check in v6\n if (!tip) {\n return null\n }\n\n tip.classList.remove(CLASS_NAME_FADE, CLASS_NAME_SHOW)\n // TODO: v6 the following can be achieved with CSS only\n tip.classList.add(`bs-${this.constructor.NAME}-auto`)\n\n const tipId = getUID(this.constructor.NAME).toString()\n\n tip.setAttribute('id', tipId)\n\n if (this._isAnimated()) {\n tip.classList.add(CLASS_NAME_FADE)\n }\n\n return tip\n }\n\n setContent(content) {\n this._newContent = content\n if (this._isShown()) {\n this._disposePopper()\n this.show()\n }\n }\n\n _getTemplateFactory(content) {\n if (this._templateFactory) {\n this._templateFactory.changeContent(content)\n } else {\n this._templateFactory = new TemplateFactory({\n ...this._config,\n // the `content` var has to be after `this._config`\n // to override config.content in case of popover\n content,\n extraClass: this._resolvePossibleFunction(this._config.customClass)\n })\n }\n\n return this._templateFactory\n }\n\n _getContentForTemplate() {\n return {\n [SELECTOR_TOOLTIP_INNER]: this._getTitle()\n }\n }\n\n _getTitle() {\n return this._resolvePossibleFunction(this._config.title) || this._element.getAttribute('data-bs-original-title')\n }\n\n // Private\n _initializeOnDelegatedTarget(event) {\n return this.constructor.getOrCreateInstance(event.delegateTarget, this._getDelegateConfig())\n }\n\n _isAnimated() {\n return this._config.animation || (this.tip && this.tip.classList.contains(CLASS_NAME_FADE))\n }\n\n _isShown() {\n return this.tip && this.tip.classList.contains(CLASS_NAME_SHOW)\n }\n\n _createPopper(tip) {\n const placement = execute(this._config.placement, [this, tip, this._element])\n const attachment = AttachmentMap[placement.toUpperCase()]\n return Popper.createPopper(this._element, tip, this._getPopperConfig(attachment))\n }\n\n _getOffset() {\n const { offset } = this._config\n\n if (typeof offset === 'string') {\n return offset.split(',').map(value => Number.parseInt(value, 10))\n }\n\n if (typeof offset === 'function') {\n return popperData => offset(popperData, this._element)\n }\n\n return offset\n }\n\n _resolvePossibleFunction(arg) {\n return execute(arg, [this._element])\n }\n\n _getPopperConfig(attachment) {\n const defaultBsPopperConfig = {\n placement: attachment,\n modifiers: [\n {\n name: 'flip',\n options: {\n fallbackPlacements: this._config.fallbackPlacements\n }\n },\n {\n name: 'offset',\n options: {\n offset: this._getOffset()\n }\n },\n {\n name: 'preventOverflow',\n options: {\n boundary: this._config.boundary\n }\n },\n {\n name: 'arrow',\n options: {\n element: `.${this.constructor.NAME}-arrow`\n }\n },\n {\n name: 'preSetPlacement',\n enabled: true,\n phase: 'beforeMain',\n fn: data => {\n // Pre-set Popper's placement attribute in order to read the arrow sizes properly.\n // Otherwise, Popper mixes up the width and height dimensions since the initial arrow style is for top placement\n this._getTipElement().setAttribute('data-popper-placement', data.state.placement)\n }\n }\n ]\n }\n\n return {\n ...defaultBsPopperConfig,\n ...execute(this._config.popperConfig, [defaultBsPopperConfig])\n }\n }\n\n _setListeners() {\n const triggers = this._config.trigger.split(' ')\n\n for (const trigger of triggers) {\n if (trigger === 'click') {\n EventHandler.on(this._element, this.constructor.eventName(EVENT_CLICK), this._config.selector, event => {\n const context = this._initializeOnDelegatedTarget(event)\n context.toggle()\n })\n } else if (trigger !== TRIGGER_MANUAL) {\n const eventIn = trigger === TRIGGER_HOVER ?\n this.constructor.eventName(EVENT_MOUSEENTER) :\n this.constructor.eventName(EVENT_FOCUSIN)\n const eventOut = trigger === TRIGGER_HOVER ?\n this.constructor.eventName(EVENT_MOUSELEAVE) :\n this.constructor.eventName(EVENT_FOCUSOUT)\n\n EventHandler.on(this._element, eventIn, this._config.selector, event => {\n const context = this._initializeOnDelegatedTarget(event)\n context._activeTrigger[event.type === 'focusin' ? TRIGGER_FOCUS : TRIGGER_HOVER] = true\n context._enter()\n })\n EventHandler.on(this._element, eventOut, this._config.selector, event => {\n const context = this._initializeOnDelegatedTarget(event)\n context._activeTrigger[event.type === 'focusout' ? TRIGGER_FOCUS : TRIGGER_HOVER] =\n context._element.contains(event.relatedTarget)\n\n context._leave()\n })\n }\n }\n\n this._hideModalHandler = () => {\n if (this._element) {\n this.hide()\n }\n }\n\n EventHandler.on(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n }\n\n _fixTitle() {\n const title = this._element.getAttribute('title')\n\n if (!title) {\n return\n }\n\n if (!this._element.getAttribute('aria-label') && !this._element.textContent.trim()) {\n this._element.setAttribute('aria-label', title)\n }\n\n this._element.setAttribute('data-bs-original-title', title) // DO NOT USE IT. Is only for backwards compatibility\n this._element.removeAttribute('title')\n }\n\n _enter() {\n if (this._isShown() || this._isHovered) {\n this._isHovered = true\n return\n }\n\n this._isHovered = true\n\n this._setTimeout(() => {\n if (this._isHovered) {\n this.show()\n }\n }, this._config.delay.show)\n }\n\n _leave() {\n if (this._isWithActiveTrigger()) {\n return\n }\n\n this._isHovered = false\n\n this._setTimeout(() => {\n if (!this._isHovered) {\n this.hide()\n }\n }, this._config.delay.hide)\n }\n\n _setTimeout(handler, timeout) {\n clearTimeout(this._timeout)\n this._timeout = setTimeout(handler, timeout)\n }\n\n _isWithActiveTrigger() {\n return Object.values(this._activeTrigger).includes(true)\n }\n\n _getConfig(config) {\n const dataAttributes = Manipulator.getDataAttributes(this._element)\n\n for (const dataAttribute of Object.keys(dataAttributes)) {\n if (DISALLOWED_ATTRIBUTES.has(dataAttribute)) {\n delete dataAttributes[dataAttribute]\n }\n }\n\n config = {\n ...dataAttributes,\n ...(typeof config === 'object' && config ? config : {})\n }\n config = this._mergeConfigObj(config)\n config = this._configAfterMerge(config)\n this._typeCheckConfig(config)\n return config\n }\n\n _configAfterMerge(config) {\n config.container = config.container === false ? document.body : getElement(config.container)\n\n if (typeof config.delay === 'number') {\n config.delay = {\n show: config.delay,\n hide: config.delay\n }\n }\n\n if (typeof config.title === 'number') {\n config.title = config.title.toString()\n }\n\n if (typeof config.content === 'number') {\n config.content = config.content.toString()\n }\n\n return config\n }\n\n _getDelegateConfig() {\n const config = {}\n\n for (const [key, value] of Object.entries(this._config)) {\n if (this.constructor.Default[key] !== value) {\n config[key] = value\n }\n }\n\n config.selector = false\n config.trigger = 'manual'\n\n // In the future can be replaced with:\n // const keysWithDifferentValues = Object.entries(this._config).filter(entry => this.constructor.Default[entry[0]] !== this._config[entry[0]])\n // `Object.fromEntries(keysWithDifferentValues)`\n return config\n }\n\n _disposePopper() {\n if (this._popper) {\n this._popper.destroy()\n this._popper = null\n }\n\n if (this.tip) {\n this.tip.remove()\n this.tip = null\n }\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Tooltip.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n })\n }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Tooltip)\n\nexport default Tooltip\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap popover.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Tooltip from './tooltip.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'popover'\n\nconst SELECTOR_TITLE = '.popover-header'\nconst SELECTOR_CONTENT = '.popover-body'\n\nconst Default = {\n ...Tooltip.Default,\n content: '',\n offset: [0, 8],\n placement: 'right',\n template: '
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' +\n '
' +\n '
',\n trigger: 'click'\n}\n\nconst DefaultType = {\n ...Tooltip.DefaultType,\n content: '(null|string|element|function)'\n}\n\n/**\n * Class definition\n */\n\nclass Popover extends Tooltip {\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Overrides\n _isWithContent() {\n return this._getTitle() || this._getContent()\n }\n\n // Private\n _getContentForTemplate() {\n return {\n [SELECTOR_TITLE]: this._getTitle(),\n [SELECTOR_CONTENT]: this._getContent()\n }\n }\n\n _getContent() {\n return this._resolvePossibleFunction(this._config.content)\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Popover.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n })\n }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Popover)\n\nexport default Popover\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap scrollspy.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport { defineJQueryPlugin, getElement, isDisabled, isVisible } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'scrollspy'\nconst DATA_KEY = 'bs.scrollspy'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_ACTIVATE = `activate${EVENT_KEY}`\nconst EVENT_CLICK = `click${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_DROPDOWN_ITEM = 'dropdown-item'\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_SPY = '[data-bs-spy=\"scroll\"]'\nconst SELECTOR_TARGET_LINKS = '[href]'\nconst SELECTOR_NAV_LIST_GROUP = '.nav, .list-group'\nconst SELECTOR_NAV_LINKS = '.nav-link'\nconst SELECTOR_NAV_ITEMS = '.nav-item'\nconst SELECTOR_LIST_ITEMS = '.list-group-item'\nconst SELECTOR_LINK_ITEMS = `${SELECTOR_NAV_LINKS}, ${SELECTOR_NAV_ITEMS} > ${SELECTOR_NAV_LINKS}, ${SELECTOR_LIST_ITEMS}`\nconst SELECTOR_DROPDOWN = '.dropdown'\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\n\nconst Default = {\n offset: null, // TODO: v6 @deprecated, keep it for backwards compatibility reasons\n rootMargin: '0px 0px -25%',\n smoothScroll: false,\n target: null,\n threshold: [0.1, 0.5, 1]\n}\n\nconst DefaultType = {\n offset: '(number|null)', // TODO v6 @deprecated, keep it for backwards compatibility reasons\n rootMargin: 'string',\n smoothScroll: 'boolean',\n target: 'element',\n threshold: 'array'\n}\n\n/**\n * Class definition\n */\n\nclass ScrollSpy extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n // this._element is the observablesContainer and config.target the menu links wrapper\n this._targetLinks = new Map()\n this._observableSections = new Map()\n this._rootElement = getComputedStyle(this._element).overflowY === 'visible' ? null : this._element\n this._activeTarget = null\n this._observer = null\n this._previousScrollData = {\n visibleEntryTop: 0,\n parentScrollTop: 0\n }\n this.refresh() // initialize\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n refresh() {\n this._initializeTargetsAndObservables()\n this._maybeEnableSmoothScroll()\n\n if (this._observer) {\n this._observer.disconnect()\n } else {\n this._observer = this._getNewObserver()\n }\n\n for (const section of this._observableSections.values()) {\n this._observer.observe(section)\n }\n }\n\n dispose() {\n this._observer.disconnect()\n super.dispose()\n }\n\n // Private\n _configAfterMerge(config) {\n // TODO: on v6 target should be given explicitly & remove the {target: 'ss-target'} case\n config.target = getElement(config.target) || document.body\n\n // TODO: v6 Only for backwards compatibility reasons. Use rootMargin only\n config.rootMargin = config.offset ? `${config.offset}px 0px -30%` : config.rootMargin\n\n if (typeof config.threshold === 'string') {\n config.threshold = config.threshold.split(',').map(value => Number.parseFloat(value))\n }\n\n return config\n }\n\n _maybeEnableSmoothScroll() {\n if (!this._config.smoothScroll) {\n return\n }\n\n // unregister any previous listeners\n EventHandler.off(this._config.target, EVENT_CLICK)\n\n EventHandler.on(this._config.target, EVENT_CLICK, SELECTOR_TARGET_LINKS, event => {\n const observableSection = this._observableSections.get(event.target.hash)\n if (observableSection) {\n event.preventDefault()\n const root = this._rootElement || window\n const height = observableSection.offsetTop - this._element.offsetTop\n if (root.scrollTo) {\n root.scrollTo({ top: height, behavior: 'smooth' })\n return\n }\n\n // Chrome 60 doesn't support `scrollTo`\n root.scrollTop = height\n }\n })\n }\n\n _getNewObserver() {\n const options = {\n root: this._rootElement,\n threshold: this._config.threshold,\n rootMargin: this._config.rootMargin\n }\n\n return new IntersectionObserver(entries => this._observerCallback(entries), options)\n }\n\n // The logic of selection\n _observerCallback(entries) {\n const targetElement = entry => this._targetLinks.get(`#${entry.target.id}`)\n const activate = entry => {\n this._previousScrollData.visibleEntryTop = entry.target.offsetTop\n this._process(targetElement(entry))\n }\n\n const parentScrollTop = (this._rootElement || document.documentElement).scrollTop\n const userScrollsDown = parentScrollTop >= this._previousScrollData.parentScrollTop\n this._previousScrollData.parentScrollTop = parentScrollTop\n\n for (const entry of entries) {\n if (!entry.isIntersecting) {\n this._activeTarget = null\n this._clearActiveClass(targetElement(entry))\n\n continue\n }\n\n const entryIsLowerThanPrevious = entry.target.offsetTop >= this._previousScrollData.visibleEntryTop\n // if we are scrolling down, pick the bigger offsetTop\n if (userScrollsDown && entryIsLowerThanPrevious) {\n activate(entry)\n // if parent isn't scrolled, let's keep the first visible item, breaking the iteration\n if (!parentScrollTop) {\n return\n }\n\n continue\n }\n\n // if we are scrolling up, pick the smallest offsetTop\n if (!userScrollsDown && !entryIsLowerThanPrevious) {\n activate(entry)\n }\n }\n }\n\n _initializeTargetsAndObservables() {\n this._targetLinks = new Map()\n this._observableSections = new Map()\n\n const targetLinks = SelectorEngine.find(SELECTOR_TARGET_LINKS, this._config.target)\n\n for (const anchor of targetLinks) {\n // ensure that the anchor has an id and is not disabled\n if (!anchor.hash || isDisabled(anchor)) {\n continue\n }\n\n const observableSection = SelectorEngine.findOne(decodeURI(anchor.hash), this._element)\n\n // ensure that the observableSection exists & is visible\n if (isVisible(observableSection)) {\n this._targetLinks.set(decodeURI(anchor.hash), anchor)\n this._observableSections.set(anchor.hash, observableSection)\n }\n }\n }\n\n _process(target) {\n if (this._activeTarget === target) {\n return\n }\n\n this._clearActiveClass(this._config.target)\n this._activeTarget = target\n target.classList.add(CLASS_NAME_ACTIVE)\n this._activateParents(target)\n\n EventHandler.trigger(this._element, EVENT_ACTIVATE, { relatedTarget: target })\n }\n\n _activateParents(target) {\n // Activate dropdown parents\n if (target.classList.contains(CLASS_NAME_DROPDOWN_ITEM)) {\n SelectorEngine.findOne(SELECTOR_DROPDOWN_TOGGLE, target.closest(SELECTOR_DROPDOWN))\n .classList.add(CLASS_NAME_ACTIVE)\n return\n }\n\n for (const listGroup of SelectorEngine.parents(target, SELECTOR_NAV_LIST_GROUP)) {\n // Set triggered links parents as active\n // With both
    and
')},createChildNavList:function(e){var t=this.createNavList();return e.append(t),t},generateNavEl:function(e,t){var n=a('');n.attr("href","#"+e),n.text(t);var r=a("
  • ");return r.append(n),r},generateNavItem:function(e){var t=this.generateAnchor(e),n=a(e),r=n.data("toc-text")||n.text();return this.generateNavEl(t,r)},getTopLevel:function(e){for(var t=1;t<=6;t++){if(1 + + + + + + + + + + + + diff --git a/docs/deps/font-awesome-6.5.2/css/all.css b/docs/deps/font-awesome-6.5.2/css/all.css new file mode 100644 index 00000000..151dd57c --- /dev/null +++ b/docs/deps/font-awesome-6.5.2/css/all.css @@ -0,0 +1,8028 @@ +/*! + * Font Awesome Free 6.5.2 by @fontawesome - https://fontawesome.com + * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) + * Copyright 2024 Fonticons, Inc. + */ +.fa { + font-family: var(--fa-style-family, "Font Awesome 6 Free"); + font-weight: var(--fa-style, 900); } + +.fa, +.fa-classic, +.fa-sharp, +.fas, +.fa-solid, +.far, +.fa-regular, +.fab, +.fa-brands { + -moz-osx-font-smoothing: grayscale; + -webkit-font-smoothing: antialiased; + display: var(--fa-display, inline-block); + font-style: normal; + font-variant: normal; + line-height: 1; + text-rendering: auto; } + +.fas, +.fa-classic, +.fa-solid, +.far, +.fa-regular { + font-family: 'Font Awesome 6 Free'; } + +.fab, +.fa-brands { + font-family: 'Font Awesome 6 Brands'; } + +.fa-1x { + font-size: 1em; } + +.fa-2x { + font-size: 2em; } + +.fa-3x { + font-size: 3em; } + +.fa-4x { + font-size: 4em; } + +.fa-5x { + font-size: 5em; } + +.fa-6x { + font-size: 6em; } + +.fa-7x { + font-size: 7em; } + +.fa-8x { + font-size: 8em; } + +.fa-9x { + font-size: 9em; } + +.fa-10x { + font-size: 10em; } + +.fa-2xs { + font-size: 0.625em; + line-height: 0.1em; + vertical-align: 0.225em; } + +.fa-xs { + font-size: 0.75em; + line-height: 0.08333em; + vertical-align: 0.125em; } + +.fa-sm { + font-size: 0.875em; + line-height: 0.07143em; + vertical-align: 0.05357em; } + +.fa-lg { + font-size: 1.25em; + line-height: 0.05em; + vertical-align: -0.075em; } + +.fa-xl { + font-size: 1.5em; + line-height: 0.04167em; + vertical-align: -0.125em; } + +.fa-2xl { + font-size: 2em; + line-height: 0.03125em; + vertical-align: -0.1875em; } + +.fa-fw { + text-align: center; + width: 1.25em; } + +.fa-ul { + list-style-type: none; + margin-left: var(--fa-li-margin, 2.5em); + padding-left: 0; } + .fa-ul > li { + position: relative; } + +.fa-li { + left: calc(var(--fa-li-width, 2em) * -1); + position: absolute; + text-align: center; + width: var(--fa-li-width, 2em); + line-height: inherit; } + +.fa-border { + border-color: var(--fa-border-color, #eee); + border-radius: var(--fa-border-radius, 0.1em); + border-style: var(--fa-border-style, solid); + border-width: var(--fa-border-width, 0.08em); + padding: var(--fa-border-padding, 0.2em 0.25em 0.15em); } + +.fa-pull-left { + float: left; + margin-right: var(--fa-pull-margin, 0.3em); } + +.fa-pull-right { + float: right; + margin-left: var(--fa-pull-margin, 0.3em); } + +.fa-beat { + -webkit-animation-name: fa-beat; + animation-name: fa-beat; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out); + animation-timing-function: var(--fa-animation-timing, ease-in-out); } + +.fa-bounce { + -webkit-animation-name: fa-bounce; + animation-name: fa-bounce; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1)); + animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1)); } + +.fa-fade { + -webkit-animation-name: fa-fade; + animation-name: fa-fade; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); + animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); } + +.fa-beat-fade { + -webkit-animation-name: fa-beat-fade; + animation-name: fa-beat-fade; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); + animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); } + +.fa-flip { + -webkit-animation-name: fa-flip; + animation-name: fa-flip; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out); + animation-timing-function: var(--fa-animation-timing, ease-in-out); } + +.fa-shake { + -webkit-animation-name: fa-shake; + animation-name: fa-shake; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, linear); + animation-timing-function: var(--fa-animation-timing, linear); } + +.fa-spin { + -webkit-animation-name: fa-spin; + animation-name: fa-spin; + -webkit-animation-delay: var(--fa-animation-delay, 0s); + animation-delay: var(--fa-animation-delay, 0s); + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 2s); + animation-duration: var(--fa-animation-duration, 2s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, linear); + animation-timing-function: var(--fa-animation-timing, linear); } + +.fa-spin-reverse { + --fa-animation-direction: reverse; } + +.fa-pulse, +.fa-spin-pulse { + -webkit-animation-name: fa-spin; + animation-name: fa-spin; + -webkit-animation-direction: var(--fa-animation-direction, normal); + animation-direction: var(--fa-animation-direction, normal); + -webkit-animation-duration: var(--fa-animation-duration, 1s); + animation-duration: var(--fa-animation-duration, 1s); + -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite); + animation-iteration-count: var(--fa-animation-iteration-count, infinite); + -webkit-animation-timing-function: var(--fa-animation-timing, steps(8)); + animation-timing-function: var(--fa-animation-timing, steps(8)); } + +@media (prefers-reduced-motion: reduce) { + .fa-beat, + .fa-bounce, + .fa-fade, + .fa-beat-fade, + .fa-flip, + .fa-pulse, + .fa-shake, + .fa-spin, + .fa-spin-pulse { + -webkit-animation-delay: -1ms; + animation-delay: -1ms; + -webkit-animation-duration: 1ms; + animation-duration: 1ms; + -webkit-animation-iteration-count: 1; + animation-iteration-count: 1; + -webkit-transition-delay: 0s; + transition-delay: 0s; + -webkit-transition-duration: 0s; + transition-duration: 0s; } } + +@-webkit-keyframes fa-beat { + 0%, 90% { + -webkit-transform: scale(1); + transform: scale(1); } + 45% { + -webkit-transform: scale(var(--fa-beat-scale, 1.25)); + transform: scale(var(--fa-beat-scale, 1.25)); } } + +@keyframes fa-beat { + 0%, 90% { + -webkit-transform: scale(1); + transform: scale(1); } + 45% { + -webkit-transform: scale(var(--fa-beat-scale, 1.25)); + transform: scale(var(--fa-beat-scale, 1.25)); } } + +@-webkit-keyframes fa-bounce { + 0% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 10% { + -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); + transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); } + 30% { + -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); + transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); } + 50% { + -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); + transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); } + 57% { + -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); + transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); } + 64% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 100% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } } + +@keyframes fa-bounce { + 0% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 10% { + -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); + transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); } + 30% { + -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); + transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); } + 50% { + -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); + transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); } + 57% { + -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); + transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); } + 64% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } + 100% { + -webkit-transform: scale(1, 1) translateY(0); + transform: scale(1, 1) translateY(0); } } + +@-webkit-keyframes fa-fade { + 50% { + opacity: var(--fa-fade-opacity, 0.4); } } + +@keyframes fa-fade { + 50% { + opacity: var(--fa-fade-opacity, 0.4); } } + +@-webkit-keyframes fa-beat-fade { + 0%, 100% { + opacity: var(--fa-beat-fade-opacity, 0.4); + -webkit-transform: scale(1); + transform: scale(1); } + 50% { + opacity: 1; + -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125)); + transform: scale(var(--fa-beat-fade-scale, 1.125)); } } + +@keyframes fa-beat-fade { + 0%, 100% { + opacity: var(--fa-beat-fade-opacity, 0.4); + -webkit-transform: scale(1); + transform: scale(1); } + 50% { + opacity: 1; + -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125)); + transform: scale(var(--fa-beat-fade-scale, 1.125)); } } + +@-webkit-keyframes fa-flip { + 50% { + -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); + transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } } + +@keyframes fa-flip { + 50% { + -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); + transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } } + +@-webkit-keyframes fa-shake { + 0% { + -webkit-transform: rotate(-15deg); + transform: rotate(-15deg); } + 4% { + -webkit-transform: rotate(15deg); + transform: rotate(15deg); } + 8%, 24% { + -webkit-transform: rotate(-18deg); + transform: rotate(-18deg); } + 12%, 28% { + -webkit-transform: rotate(18deg); + transform: rotate(18deg); } + 16% { + -webkit-transform: rotate(-22deg); + transform: rotate(-22deg); } + 20% { + -webkit-transform: rotate(22deg); + transform: rotate(22deg); } + 32% { + -webkit-transform: rotate(-12deg); + transform: rotate(-12deg); } + 36% { + -webkit-transform: rotate(12deg); + transform: rotate(12deg); } + 40%, 100% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } } + +@keyframes fa-shake { + 0% { + -webkit-transform: rotate(-15deg); + transform: rotate(-15deg); } + 4% { + -webkit-transform: rotate(15deg); + transform: rotate(15deg); } + 8%, 24% { + -webkit-transform: rotate(-18deg); + transform: rotate(-18deg); } + 12%, 28% { + -webkit-transform: rotate(18deg); + transform: rotate(18deg); } + 16% { + -webkit-transform: rotate(-22deg); + transform: rotate(-22deg); } + 20% { + -webkit-transform: rotate(22deg); + transform: rotate(22deg); } + 32% { + -webkit-transform: rotate(-12deg); + transform: rotate(-12deg); } + 36% { + -webkit-transform: rotate(12deg); + transform: rotate(12deg); } + 40%, 100% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } } + +@-webkit-keyframes fa-spin { + 0% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } + 100% { + -webkit-transform: rotate(360deg); + transform: rotate(360deg); } } + +@keyframes fa-spin { + 0% { + -webkit-transform: rotate(0deg); + transform: rotate(0deg); } + 100% { + -webkit-transform: rotate(360deg); + transform: rotate(360deg); } } + +.fa-rotate-90 { + -webkit-transform: rotate(90deg); + transform: rotate(90deg); } + +.fa-rotate-180 { + -webkit-transform: rotate(180deg); + transform: rotate(180deg); } + +.fa-rotate-270 { + -webkit-transform: rotate(270deg); + transform: rotate(270deg); } + +.fa-flip-horizontal { + -webkit-transform: scale(-1, 1); + transform: scale(-1, 1); } + +.fa-flip-vertical { + -webkit-transform: scale(1, -1); + transform: scale(1, -1); } + +.fa-flip-both, +.fa-flip-horizontal.fa-flip-vertical { + -webkit-transform: scale(-1, -1); + transform: scale(-1, -1); } + +.fa-rotate-by { + -webkit-transform: rotate(var(--fa-rotate-angle, 0)); + transform: rotate(var(--fa-rotate-angle, 0)); } + +.fa-stack { + display: inline-block; + height: 2em; + line-height: 2em; + position: relative; + vertical-align: middle; + width: 2.5em; } + +.fa-stack-1x, +.fa-stack-2x { + left: 0; + position: absolute; + text-align: center; + width: 100%; + z-index: var(--fa-stack-z-index, auto); } + +.fa-stack-1x { + line-height: inherit; } + +.fa-stack-2x { + font-size: 2em; } + +.fa-inverse { + color: var(--fa-inverse, #fff); } + +/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen +readers do not read off random characters that represent icons */ + +.fa-0::before { + content: "\30"; } + +.fa-1::before { + content: "\31"; } + +.fa-2::before { + content: "\32"; } + +.fa-3::before { + content: "\33"; } + +.fa-4::before { + content: "\34"; } + +.fa-5::before { + content: "\35"; } + +.fa-6::before { + content: "\36"; } + +.fa-7::before { + content: "\37"; } + +.fa-8::before { + content: "\38"; } + +.fa-9::before { + content: "\39"; } + +.fa-fill-drip::before { + content: "\f576"; } + +.fa-arrows-to-circle::before { + content: "\e4bd"; } + +.fa-circle-chevron-right::before { + content: "\f138"; } + +.fa-chevron-circle-right::before { + content: "\f138"; } + +.fa-at::before { + content: "\40"; } + +.fa-trash-can::before { + content: "\f2ed"; } + +.fa-trash-alt::before { + content: "\f2ed"; } + +.fa-text-height::before { + content: "\f034"; } + +.fa-user-xmark::before { + content: "\f235"; } + +.fa-user-times::before { + content: "\f235"; } + +.fa-stethoscope::before { + content: "\f0f1"; } + +.fa-message::before { + content: "\f27a"; } + +.fa-comment-alt::before { + content: "\f27a"; } + +.fa-info::before { + content: "\f129"; } + +.fa-down-left-and-up-right-to-center::before { + content: "\f422"; } + +.fa-compress-alt::before { + content: "\f422"; } + +.fa-explosion::before { + content: "\e4e9"; } + +.fa-file-lines::before { + content: "\f15c"; } + +.fa-file-alt::before { + content: "\f15c"; } + +.fa-file-text::before { + content: "\f15c"; } + +.fa-wave-square::before { + content: "\f83e"; } + +.fa-ring::before { + content: "\f70b"; } + +.fa-building-un::before { + content: "\e4d9"; } + +.fa-dice-three::before { + content: "\f527"; } + +.fa-calendar-days::before { + content: "\f073"; } + +.fa-calendar-alt::before { + content: "\f073"; } + +.fa-anchor-circle-check::before { + content: "\e4aa"; } + +.fa-building-circle-arrow-right::before { + content: "\e4d1"; } + +.fa-volleyball::before { + content: "\f45f"; } + +.fa-volleyball-ball::before { + content: "\f45f"; } + +.fa-arrows-up-to-line::before { + content: "\e4c2"; } + +.fa-sort-down::before { + content: "\f0dd"; } + +.fa-sort-desc::before { + content: "\f0dd"; } + +.fa-circle-minus::before { + content: "\f056"; } + +.fa-minus-circle::before { + content: "\f056"; } + +.fa-door-open::before { + content: "\f52b"; } + +.fa-right-from-bracket::before { + content: "\f2f5"; } + +.fa-sign-out-alt::before { + content: "\f2f5"; } + +.fa-atom::before { + content: "\f5d2"; } + +.fa-soap::before { + content: "\e06e"; } + +.fa-icons::before { + content: "\f86d"; } + +.fa-heart-music-camera-bolt::before { + content: "\f86d"; } + +.fa-microphone-lines-slash::before { + content: "\f539"; } + +.fa-microphone-alt-slash::before { + content: "\f539"; } + +.fa-bridge-circle-check::before { + content: "\e4c9"; } + +.fa-pump-medical::before { + content: "\e06a"; } + +.fa-fingerprint::before { + content: "\f577"; } + +.fa-hand-point-right::before { + content: "\f0a4"; } + +.fa-magnifying-glass-location::before { + content: "\f689"; } + +.fa-search-location::before { + content: "\f689"; } + +.fa-forward-step::before { + content: "\f051"; } + +.fa-step-forward::before { + content: "\f051"; } + +.fa-face-smile-beam::before { + content: "\f5b8"; } + +.fa-smile-beam::before { + content: "\f5b8"; } + +.fa-flag-checkered::before { + content: "\f11e"; } + +.fa-football::before { + content: "\f44e"; } + +.fa-football-ball::before { + content: "\f44e"; } + +.fa-school-circle-exclamation::before { + content: "\e56c"; } + +.fa-crop::before { + content: "\f125"; } + +.fa-angles-down::before { + content: "\f103"; } + +.fa-angle-double-down::before { + content: "\f103"; } + +.fa-users-rectangle::before { + content: "\e594"; } + +.fa-people-roof::before { + content: "\e537"; } + +.fa-people-line::before { + content: "\e534"; } + +.fa-beer-mug-empty::before { + content: "\f0fc"; } + +.fa-beer::before { + content: "\f0fc"; } + +.fa-diagram-predecessor::before { + content: "\e477"; } + +.fa-arrow-up-long::before { + content: "\f176"; } + +.fa-long-arrow-up::before { + content: "\f176"; } + +.fa-fire-flame-simple::before { + content: "\f46a"; } + +.fa-burn::before { + content: "\f46a"; } + +.fa-person::before { + content: "\f183"; } + +.fa-male::before { + content: "\f183"; } + +.fa-laptop::before { + content: "\f109"; } + +.fa-file-csv::before { + content: "\f6dd"; } + +.fa-menorah::before { + content: "\f676"; } + +.fa-truck-plane::before { + content: "\e58f"; } + +.fa-record-vinyl::before { + content: "\f8d9"; } + +.fa-face-grin-stars::before { + content: "\f587"; } + +.fa-grin-stars::before { + content: "\f587"; } + +.fa-bong::before { + content: "\f55c"; } + +.fa-spaghetti-monster-flying::before { + content: "\f67b"; } + +.fa-pastafarianism::before { + content: "\f67b"; } + +.fa-arrow-down-up-across-line::before { + content: "\e4af"; } + +.fa-spoon::before { + content: "\f2e5"; } + +.fa-utensil-spoon::before { + content: "\f2e5"; } + +.fa-jar-wheat::before { + content: "\e517"; } + +.fa-envelopes-bulk::before { + content: "\f674"; } + +.fa-mail-bulk::before { + content: "\f674"; } + +.fa-file-circle-exclamation::before { + content: "\e4eb"; } + +.fa-circle-h::before { + content: "\f47e"; } + +.fa-hospital-symbol::before { + content: "\f47e"; } + +.fa-pager::before { + content: "\f815"; } + +.fa-address-book::before { + content: "\f2b9"; } + +.fa-contact-book::before { + content: "\f2b9"; } + +.fa-strikethrough::before { + content: "\f0cc"; } + +.fa-k::before { + content: "\4b"; } + +.fa-landmark-flag::before { + content: "\e51c"; } + +.fa-pencil::before { + content: "\f303"; } + +.fa-pencil-alt::before { + content: "\f303"; } + +.fa-backward::before { + content: "\f04a"; } + +.fa-caret-right::before { + content: "\f0da"; } + +.fa-comments::before { + content: "\f086"; } + +.fa-paste::before { + content: "\f0ea"; } + +.fa-file-clipboard::before { + content: "\f0ea"; } + +.fa-code-pull-request::before { + content: "\e13c"; } + +.fa-clipboard-list::before { + content: "\f46d"; } + +.fa-truck-ramp-box::before { + content: "\f4de"; } + +.fa-truck-loading::before { + content: "\f4de"; } + +.fa-user-check::before { + content: "\f4fc"; } + +.fa-vial-virus::before { + content: "\e597"; } + +.fa-sheet-plastic::before { + content: "\e571"; } + +.fa-blog::before { + content: "\f781"; } + +.fa-user-ninja::before { + content: "\f504"; } + +.fa-person-arrow-up-from-line::before { + content: "\e539"; } + +.fa-scroll-torah::before { + content: "\f6a0"; } + +.fa-torah::before { + content: "\f6a0"; } + +.fa-broom-ball::before { + content: "\f458"; } + +.fa-quidditch::before { + content: "\f458"; } + +.fa-quidditch-broom-ball::before { + content: "\f458"; } + +.fa-toggle-off::before { + content: "\f204"; } + +.fa-box-archive::before { + content: "\f187"; } + +.fa-archive::before { + content: "\f187"; } + +.fa-person-drowning::before { + content: "\e545"; } + +.fa-arrow-down-9-1::before { + content: "\f886"; } + +.fa-sort-numeric-desc::before { + content: "\f886"; } + +.fa-sort-numeric-down-alt::before { + content: "\f886"; } + +.fa-face-grin-tongue-squint::before { + content: "\f58a"; } + +.fa-grin-tongue-squint::before { + content: "\f58a"; } + +.fa-spray-can::before { + content: "\f5bd"; } + +.fa-truck-monster::before { + content: "\f63b"; } + +.fa-w::before { + content: "\57"; } + +.fa-earth-africa::before { + content: "\f57c"; } + +.fa-globe-africa::before { + content: "\f57c"; } + +.fa-rainbow::before { + content: "\f75b"; } + +.fa-circle-notch::before { + content: "\f1ce"; } + +.fa-tablet-screen-button::before { + content: "\f3fa"; } + +.fa-tablet-alt::before { + content: "\f3fa"; } + +.fa-paw::before { + content: "\f1b0"; } + +.fa-cloud::before { + content: "\f0c2"; } + +.fa-trowel-bricks::before { + content: "\e58a"; } + +.fa-face-flushed::before { + content: "\f579"; } + +.fa-flushed::before { + content: "\f579"; } + +.fa-hospital-user::before { + content: "\f80d"; } + +.fa-tent-arrow-left-right::before { + content: "\e57f"; } + +.fa-gavel::before { + content: "\f0e3"; } + +.fa-legal::before { + content: "\f0e3"; } + +.fa-binoculars::before { + content: "\f1e5"; } + +.fa-microphone-slash::before { + content: "\f131"; } + +.fa-box-tissue::before { + content: "\e05b"; } + +.fa-motorcycle::before { + content: "\f21c"; } + +.fa-bell-concierge::before { + content: "\f562"; } + +.fa-concierge-bell::before { + content: "\f562"; } + +.fa-pen-ruler::before { + content: "\f5ae"; } + +.fa-pencil-ruler::before { + content: "\f5ae"; } + +.fa-people-arrows::before { + content: "\e068"; } + +.fa-people-arrows-left-right::before { + content: "\e068"; } + +.fa-mars-and-venus-burst::before { + content: "\e523"; } + +.fa-square-caret-right::before { + content: "\f152"; } + +.fa-caret-square-right::before { + content: "\f152"; } + +.fa-scissors::before { + content: "\f0c4"; } + +.fa-cut::before { + content: "\f0c4"; } + +.fa-sun-plant-wilt::before { + content: "\e57a"; } + +.fa-toilets-portable::before { + content: "\e584"; } + +.fa-hockey-puck::before { + content: "\f453"; } + +.fa-table::before { + content: "\f0ce"; } + +.fa-magnifying-glass-arrow-right::before { + content: "\e521"; } + +.fa-tachograph-digital::before { + content: "\f566"; } + +.fa-digital-tachograph::before { + content: "\f566"; } + +.fa-users-slash::before { + content: "\e073"; } + +.fa-clover::before { + content: "\e139"; } + +.fa-reply::before { + content: "\f3e5"; } + +.fa-mail-reply::before { + content: "\f3e5"; } + +.fa-star-and-crescent::before { + content: "\f699"; } + +.fa-house-fire::before { + content: "\e50c"; } + +.fa-square-minus::before { + content: "\f146"; } + +.fa-minus-square::before { + content: "\f146"; } + +.fa-helicopter::before { + content: "\f533"; } + +.fa-compass::before { + content: "\f14e"; } + +.fa-square-caret-down::before { + content: "\f150"; } + +.fa-caret-square-down::before { + content: "\f150"; } + +.fa-file-circle-question::before { + content: "\e4ef"; } + +.fa-laptop-code::before { + content: "\f5fc"; } + +.fa-swatchbook::before { + content: "\f5c3"; } + +.fa-prescription-bottle::before { + content: "\f485"; } + +.fa-bars::before { + content: "\f0c9"; } + +.fa-navicon::before { + content: "\f0c9"; } + +.fa-people-group::before { + content: "\e533"; } + +.fa-hourglass-end::before { + content: "\f253"; } + +.fa-hourglass-3::before { + content: "\f253"; } + +.fa-heart-crack::before { + content: "\f7a9"; } + +.fa-heart-broken::before { + content: "\f7a9"; } + +.fa-square-up-right::before { + content: "\f360"; } + +.fa-external-link-square-alt::before { + content: "\f360"; } + +.fa-face-kiss-beam::before { + content: "\f597"; } + +.fa-kiss-beam::before { + content: "\f597"; } + +.fa-film::before { + content: "\f008"; } + +.fa-ruler-horizontal::before { + content: "\f547"; } + +.fa-people-robbery::before { + content: "\e536"; } + +.fa-lightbulb::before { + content: "\f0eb"; } + +.fa-caret-left::before { + content: "\f0d9"; } + +.fa-circle-exclamation::before { + content: "\f06a"; } + +.fa-exclamation-circle::before { + content: "\f06a"; } + +.fa-school-circle-xmark::before { + content: "\e56d"; } + +.fa-arrow-right-from-bracket::before { + content: "\f08b"; } + +.fa-sign-out::before { + content: "\f08b"; } + +.fa-circle-chevron-down::before { + content: "\f13a"; } + +.fa-chevron-circle-down::before { + content: "\f13a"; } + +.fa-unlock-keyhole::before { + content: "\f13e"; } + +.fa-unlock-alt::before { + content: "\f13e"; } + +.fa-cloud-showers-heavy::before { + content: "\f740"; } + +.fa-headphones-simple::before { + content: "\f58f"; } + +.fa-headphones-alt::before { + content: "\f58f"; } + +.fa-sitemap::before { + content: "\f0e8"; } + +.fa-circle-dollar-to-slot::before { + content: "\f4b9"; } + +.fa-donate::before { + content: "\f4b9"; } + +.fa-memory::before { + content: "\f538"; } + +.fa-road-spikes::before { + content: "\e568"; } + +.fa-fire-burner::before { + content: "\e4f1"; } + +.fa-flag::before { + content: "\f024"; } + +.fa-hanukiah::before { + content: "\f6e6"; } + +.fa-feather::before { + content: "\f52d"; } + +.fa-volume-low::before { + content: "\f027"; } + +.fa-volume-down::before { + content: "\f027"; } + +.fa-comment-slash::before { + content: "\f4b3"; } + +.fa-cloud-sun-rain::before { + content: "\f743"; } + +.fa-compress::before { + content: "\f066"; } + +.fa-wheat-awn::before { + content: "\e2cd"; } + +.fa-wheat-alt::before { + content: "\e2cd"; } + +.fa-ankh::before { + content: "\f644"; } + +.fa-hands-holding-child::before { + content: "\e4fa"; } + +.fa-asterisk::before { + content: "\2a"; } + +.fa-square-check::before { + content: "\f14a"; } + +.fa-check-square::before { + content: "\f14a"; } + +.fa-peseta-sign::before { + content: "\e221"; } + +.fa-heading::before { + content: "\f1dc"; } + +.fa-header::before { + content: "\f1dc"; } + +.fa-ghost::before { + content: "\f6e2"; } + +.fa-list::before { + content: "\f03a"; } + +.fa-list-squares::before { + content: "\f03a"; } + +.fa-square-phone-flip::before { + content: "\f87b"; } + +.fa-phone-square-alt::before { + content: "\f87b"; } + +.fa-cart-plus::before { + content: "\f217"; } + +.fa-gamepad::before { + content: "\f11b"; } + +.fa-circle-dot::before { + content: "\f192"; } + +.fa-dot-circle::before { + content: "\f192"; } + +.fa-face-dizzy::before { + content: "\f567"; } + +.fa-dizzy::before { + content: "\f567"; } + +.fa-egg::before { + content: "\f7fb"; } + +.fa-house-medical-circle-xmark::before { + content: "\e513"; } + +.fa-campground::before { + content: "\f6bb"; } + +.fa-folder-plus::before { + content: "\f65e"; } + +.fa-futbol::before { + content: "\f1e3"; } + +.fa-futbol-ball::before { + content: "\f1e3"; } + +.fa-soccer-ball::before { + content: "\f1e3"; } + +.fa-paintbrush::before { + content: "\f1fc"; } + +.fa-paint-brush::before { + content: "\f1fc"; } + +.fa-lock::before { + content: "\f023"; } + +.fa-gas-pump::before { + content: "\f52f"; } + +.fa-hot-tub-person::before { + content: "\f593"; } + +.fa-hot-tub::before { + content: "\f593"; } + +.fa-map-location::before { + content: "\f59f"; } + +.fa-map-marked::before { + content: "\f59f"; } + +.fa-house-flood-water::before { + content: "\e50e"; } + +.fa-tree::before { + content: "\f1bb"; } + +.fa-bridge-lock::before { + content: "\e4cc"; } + +.fa-sack-dollar::before { + content: "\f81d"; } + +.fa-pen-to-square::before { + content: "\f044"; } + +.fa-edit::before { + content: "\f044"; } + +.fa-car-side::before { + content: "\f5e4"; } + +.fa-share-nodes::before { + content: "\f1e0"; } + +.fa-share-alt::before { + content: "\f1e0"; } + +.fa-heart-circle-minus::before { + content: "\e4ff"; } + +.fa-hourglass-half::before { + content: "\f252"; } + +.fa-hourglass-2::before { + content: "\f252"; } + +.fa-microscope::before { + content: "\f610"; } + +.fa-sink::before { + content: "\e06d"; } + +.fa-bag-shopping::before { + content: "\f290"; } + +.fa-shopping-bag::before { + content: "\f290"; } + +.fa-arrow-down-z-a::before { + content: "\f881"; } + +.fa-sort-alpha-desc::before { + content: "\f881"; } + +.fa-sort-alpha-down-alt::before { + content: "\f881"; } + +.fa-mitten::before { + content: "\f7b5"; } + 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content: "\f132"; } + +.fa-arrow-up-short-wide::before { + content: "\f885"; } + +.fa-sort-amount-up-alt::before { + content: "\f885"; } + +.fa-house-medical::before { + content: "\e3b2"; } + +.fa-golf-ball-tee::before { + content: "\f450"; } + +.fa-golf-ball::before { + content: "\f450"; } + +.fa-circle-chevron-left::before { + content: "\f137"; } + +.fa-chevron-circle-left::before { + content: "\f137"; } + +.fa-house-chimney-window::before { + content: "\e00d"; } + +.fa-pen-nib::before { + content: "\f5ad"; } + +.fa-tent-arrow-turn-left::before { + content: "\e580"; } + +.fa-tents::before { + content: "\e582"; } + +.fa-wand-magic::before { + content: "\f0d0"; } + +.fa-magic::before { + content: "\f0d0"; } + +.fa-dog::before { + content: "\f6d3"; } + +.fa-carrot::before { + content: "\f787"; } + +.fa-moon::before { + content: "\f186"; } + +.fa-wine-glass-empty::before { + content: "\f5ce"; } + +.fa-wine-glass-alt::before { + content: "\f5ce"; } + +.fa-cheese::before { + content: "\f7ef"; } + +.fa-yin-yang::before { + content: "\f6ad"; } + +.fa-music::before { + content: "\f001"; } + +.fa-code-commit::before { + content: "\f386"; } + +.fa-temperature-low::before { + content: "\f76b"; } + +.fa-person-biking::before { + content: "\f84a"; } + +.fa-biking::before { + content: "\f84a"; } + +.fa-broom::before { + content: "\f51a"; } + +.fa-shield-heart::before { + content: "\e574"; } + +.fa-gopuram::before { + content: "\f664"; } + +.fa-earth-oceania::before { + content: "\e47b"; } + +.fa-globe-oceania::before { + content: "\e47b"; } + +.fa-square-xmark::before { + content: "\f2d3"; } + +.fa-times-square::before { + content: "\f2d3"; } + +.fa-xmark-square::before { + content: "\f2d3"; } + +.fa-hashtag::before { + content: "\23"; } + +.fa-up-right-and-down-left-from-center::before { + content: "\f424"; } + +.fa-expand-alt::before { + content: "\f424"; } + +.fa-oil-can::before { + content: "\f613"; } + +.fa-t::before { + content: "\54"; } + +.fa-hippo::before { + content: "\f6ed"; } + +.fa-chart-column::before { + content: "\e0e3"; } + +.fa-infinity::before { + content: "\f534"; } + +.fa-vial-circle-check::before { + content: "\e596"; } + +.fa-person-arrow-down-to-line::before { + content: "\e538"; } + +.fa-voicemail::before { + content: "\f897"; } + +.fa-fan::before { + content: "\f863"; } + +.fa-person-walking-luggage::before { + content: "\e554"; } + +.fa-up-down::before { + content: "\f338"; } + +.fa-arrows-alt-v::before { + content: "\f338"; } + +.fa-cloud-moon-rain::before { + content: "\f73c"; } + +.fa-calendar::before { + content: "\f133"; } + +.fa-trailer::before { + content: "\e041"; } + +.fa-bahai::before { + content: "\f666"; } + +.fa-haykal::before { + content: "\f666"; } + +.fa-sd-card::before { + content: "\f7c2"; } + +.fa-dragon::before { + content: "\f6d5"; } + +.fa-shoe-prints::before { + content: "\f54b"; } + +.fa-circle-plus::before { + content: "\f055"; } + +.fa-plus-circle::before { + content: "\f055"; } + 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} + +.fa-border-all::before { + content: "\f84c"; } + +.fa-face-angry::before { + content: "\f556"; } + +.fa-angry::before { + content: "\f556"; } + +.fa-cookie-bite::before { + content: "\f564"; } + +.fa-arrow-trend-down::before { + content: "\e097"; } + +.fa-rss::before { + content: "\f09e"; } + +.fa-feed::before { + content: "\f09e"; } + +.fa-draw-polygon::before { + content: "\f5ee"; } + +.fa-scale-balanced::before { + content: "\f24e"; } + +.fa-balance-scale::before { + content: "\f24e"; } + +.fa-gauge-simple-high::before { + content: "\f62a"; } + +.fa-tachometer::before { + content: "\f62a"; } + +.fa-tachometer-fast::before { + content: "\f62a"; } + +.fa-shower::before { + content: "\f2cc"; } + +.fa-desktop::before { + content: "\f390"; } + +.fa-desktop-alt::before { + content: "\f390"; } + +.fa-m::before { + content: "\4d"; } + +.fa-table-list::before { + content: "\f00b"; } + +.fa-th-list::before { + content: "\f00b"; } + +.fa-comment-sms::before { + content: "\f7cd"; } + 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+ content: "\e569"; } + +.fa-earth-europe::before { + content: "\f7a2"; } + +.fa-globe-europe::before { + content: "\f7a2"; } + +.fa-cart-flatbed-suitcase::before { + content: "\f59d"; } + +.fa-luggage-cart::before { + content: "\f59d"; } + +.fa-rectangle-xmark::before { + content: "\f410"; } + +.fa-rectangle-times::before { + content: "\f410"; } + +.fa-times-rectangle::before { + content: "\f410"; } + +.fa-window-close::before { + content: "\f410"; } + +.fa-baht-sign::before { + content: "\e0ac"; } + +.fa-book-open::before { + content: "\f518"; } + +.fa-book-journal-whills::before { + content: "\f66a"; } + +.fa-journal-whills::before { + content: "\f66a"; } + +.fa-handcuffs::before { + content: "\e4f8"; } + +.fa-triangle-exclamation::before { + content: "\f071"; } + +.fa-exclamation-triangle::before { + content: "\f071"; } + +.fa-warning::before { + content: "\f071"; } + +.fa-database::before { + content: "\f1c0"; } + +.fa-share::before { + content: "\f064"; } + +.fa-mail-forward::before { + content: "\f064"; } + +.fa-bottle-droplet::before { + content: "\e4c4"; } + +.fa-mask-face::before { + content: "\e1d7"; } + +.fa-hill-rockslide::before { + content: "\e508"; } + +.fa-right-left::before { + content: "\f362"; } + +.fa-exchange-alt::before { + content: "\f362"; } + +.fa-paper-plane::before { + content: "\f1d8"; } + +.fa-road-circle-exclamation::before { + content: "\e565"; } + +.fa-dungeon::before { + content: "\f6d9"; } + +.fa-align-right::before { + content: "\f038"; } + +.fa-money-bill-1-wave::before { + content: "\f53b"; } + +.fa-money-bill-wave-alt::before { + content: "\f53b"; } + +.fa-life-ring::before { + content: "\f1cd"; } + +.fa-hands::before { + content: "\f2a7"; } + +.fa-sign-language::before { + content: "\f2a7"; } + +.fa-signing::before { + content: "\f2a7"; } + +.fa-calendar-day::before { + content: "\f783"; } + +.fa-water-ladder::before { + content: "\f5c5"; } + +.fa-ladder-water::before { + content: "\f5c5"; } + +.fa-swimming-pool::before { + content: "\f5c5"; } + +.fa-arrows-up-down::before { + content: "\f07d"; } + +.fa-arrows-v::before { + content: "\f07d"; } + +.fa-face-grimace::before { + content: "\f57f"; } + +.fa-grimace::before { + content: "\f57f"; } + +.fa-wheelchair-move::before { + content: "\e2ce"; } + +.fa-wheelchair-alt::before { + content: "\e2ce"; } + +.fa-turn-down::before { + content: "\f3be"; } + +.fa-level-down-alt::before { + content: "\f3be"; } + +.fa-person-walking-arrow-right::before { + content: "\e552"; } + +.fa-square-envelope::before { + content: "\f199"; } + +.fa-envelope-square::before { + content: "\f199"; } + +.fa-dice::before { + content: "\f522"; } + +.fa-bowling-ball::before { + content: "\f436"; } + +.fa-brain::before { + content: "\f5dc"; } + +.fa-bandage::before { + content: "\f462"; } + +.fa-band-aid::before { + content: "\f462"; } + +.fa-calendar-minus::before { + content: "\f272"; } + +.fa-circle-xmark::before { + content: "\f057"; } + +.fa-times-circle::before { + content: "\f057"; } + +.fa-xmark-circle::before { + content: "\f057"; } + +.fa-gifts::before { + content: "\f79c"; } + +.fa-hotel::before { + content: "\f594"; } + +.fa-earth-asia::before { + content: "\f57e"; } + +.fa-globe-asia::before { + content: "\f57e"; } + +.fa-id-card-clip::before { + content: "\f47f"; } + +.fa-id-card-alt::before { + content: "\f47f"; } + +.fa-magnifying-glass-plus::before { + content: "\f00e"; } + +.fa-search-plus::before { + content: "\f00e"; } + +.fa-thumbs-up::before { + content: "\f164"; } + +.fa-user-clock::before { + content: "\f4fd"; } + +.fa-hand-dots::before { + content: "\f461"; } + +.fa-allergies::before { + content: "\f461"; } + +.fa-file-invoice::before { + content: "\f570"; } + +.fa-window-minimize::before { + content: "\f2d1"; } + +.fa-mug-saucer::before { + content: "\f0f4"; } + +.fa-coffee::before { + content: "\f0f4"; } + +.fa-brush::before { + content: "\f55d"; } + +.fa-mask::before { + content: "\f6fa"; } + +.fa-magnifying-glass-minus::before { + content: "\f010"; } + +.fa-search-minus::before { + content: "\f010"; } + +.fa-ruler-vertical::before { + content: "\f548"; } + +.fa-user-large::before { + content: "\f406"; } + +.fa-user-alt::before { + content: "\f406"; } + +.fa-train-tram::before { + content: "\e5b4"; } + +.fa-user-nurse::before { + content: "\f82f"; } + +.fa-syringe::before { + content: "\f48e"; } + +.fa-cloud-sun::before { + content: "\f6c4"; } + +.fa-stopwatch-20::before { + content: "\e06f"; } + +.fa-square-full::before { + content: "\f45c"; } + +.fa-magnet::before { + content: "\f076"; } + +.fa-jar::before { + content: "\e516"; } + +.fa-note-sticky::before { + content: "\f249"; } + +.fa-sticky-note::before { + content: "\f249"; } + +.fa-bug-slash::before { + content: "\e490"; } + +.fa-arrow-up-from-water-pump::before { + content: "\e4b6"; } + +.fa-bone::before { + content: "\f5d7"; } + +.fa-user-injured::before { + content: "\f728"; } + +.fa-face-sad-tear::before { + content: "\f5b4"; } + +.fa-sad-tear::before { + content: "\f5b4"; } + +.fa-plane::before { + content: "\f072"; } + +.fa-tent-arrows-down::before { + content: "\e581"; } + +.fa-exclamation::before { + content: "\21"; } + +.fa-arrows-spin::before { + content: "\e4bb"; } + +.fa-print::before { + content: "\f02f"; } + +.fa-turkish-lira-sign::before { + content: "\e2bb"; } + +.fa-try::before { + content: "\e2bb"; } + +.fa-turkish-lira::before { + content: "\e2bb"; } + +.fa-dollar-sign::before { + content: "\24"; } + +.fa-dollar::before { + content: "\24"; } + +.fa-usd::before { + content: "\24"; } + +.fa-x::before { + content: "\58"; } + +.fa-magnifying-glass-dollar::before { + content: "\f688"; } + +.fa-search-dollar::before { + content: "\f688"; } + +.fa-users-gear::before { + content: "\f509"; } + +.fa-users-cog::before { + content: "\f509"; } + +.fa-person-military-pointing::before { + content: "\e54a"; } + +.fa-building-columns::before { + content: "\f19c"; } + +.fa-bank::before { + content: "\f19c"; } + +.fa-institution::before { + content: "\f19c"; } + +.fa-museum::before { + content: "\f19c"; } + +.fa-university::before { + content: "\f19c"; } + +.fa-umbrella::before { + content: "\f0e9"; } + +.fa-trowel::before { + content: "\e589"; } + +.fa-d::before { + content: "\44"; } + +.fa-stapler::before { + content: "\e5af"; } + +.fa-masks-theater::before { + content: "\f630"; } + +.fa-theater-masks::before { + content: "\f630"; } + +.fa-kip-sign::before { + content: "\e1c4"; } + +.fa-hand-point-left::before { + content: "\f0a5"; } + +.fa-handshake-simple::before { + content: "\f4c6"; } + +.fa-handshake-alt::before { + content: "\f4c6"; } + +.fa-jet-fighter::before { + content: "\f0fb"; } + +.fa-fighter-jet::before { + content: "\f0fb"; } + +.fa-square-share-nodes::before { + content: "\f1e1"; } + +.fa-share-alt-square::before { + content: "\f1e1"; } + +.fa-barcode::before { + content: "\f02a"; } + +.fa-plus-minus::before { + content: "\e43c"; } + +.fa-video::before { + content: "\f03d"; } + +.fa-video-camera::before { + content: "\f03d"; } + +.fa-graduation-cap::before { + content: "\f19d"; } + +.fa-mortar-board::before { + content: "\f19d"; } + +.fa-hand-holding-medical::before { + content: "\e05c"; } + +.fa-person-circle-check::before { + content: "\e53e"; } + +.fa-turn-up::before { + content: "\f3bf"; } + +.fa-level-up-alt::before { + content: "\f3bf"; } + +.sr-only, +.fa-sr-only { + position: absolute; + width: 1px; + height: 1px; + padding: 0; + margin: -1px; + overflow: hidden; + clip: rect(0, 0, 0, 0); + white-space: nowrap; + border-width: 0; } + +.sr-only-focusable:not(:focus), +.fa-sr-only-focusable:not(:focus) { + position: absolute; + width: 1px; + height: 1px; + padding: 0; + margin: -1px; + overflow: hidden; + clip: rect(0, 0, 0, 0); + white-space: nowrap; + border-width: 0; } +:root, :host { + --fa-style-family-brands: 'Font Awesome 6 Brands'; + --fa-font-brands: normal 400 1em/1 'Font Awesome 6 Brands'; } + +@font-face { + font-family: 'Font Awesome 6 Brands'; + font-style: normal; + font-weight: 400; + font-display: block; + src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); } + +.fab, +.fa-brands { + font-weight: 400; } + +.fa-monero:before { + content: "\f3d0"; } + +.fa-hooli:before { + content: "\f427"; } + +.fa-yelp:before { + content: "\f1e9"; } + +.fa-cc-visa:before { + content: "\f1f0"; } + +.fa-lastfm:before { + content: "\f202"; } + +.fa-shopware:before { + content: "\f5b5"; } + +.fa-creative-commons-nc:before { + content: "\f4e8"; } + +.fa-aws:before { + content: "\f375"; } + +.fa-redhat:before { + content: "\f7bc"; } + +.fa-yoast:before { + content: "\f2b1"; } + +.fa-cloudflare:before { + content: "\e07d"; } + +.fa-ups:before { + content: "\f7e0"; } + +.fa-pixiv:before { + content: "\e640"; } + +.fa-wpexplorer:before { + content: "\f2de"; } + +.fa-dyalog:before { + content: "\f399"; } + +.fa-bity:before { + content: "\f37a"; } + +.fa-stackpath:before { + content: "\f842"; } + +.fa-buysellads:before { + content: "\f20d"; } + +.fa-first-order:before { + content: "\f2b0"; } + +.fa-modx:before { + content: "\f285"; } + +.fa-guilded:before { + content: "\e07e"; } + +.fa-vnv:before { + content: "\f40b"; } + +.fa-square-js:before { + content: "\f3b9"; } + +.fa-js-square:before { + content: "\f3b9"; } + +.fa-microsoft:before { + content: "\f3ca"; } + +.fa-qq:before { + content: "\f1d6"; } + +.fa-orcid:before { + content: "\f8d2"; } + +.fa-java:before { + content: "\f4e4"; } + +.fa-invision:before { + content: "\f7b0"; } + +.fa-creative-commons-pd-alt:before { + content: "\f4ed"; } + +.fa-centercode:before { + content: "\f380"; } + +.fa-glide-g:before { + content: "\f2a6"; } + +.fa-drupal:before { + content: "\f1a9"; } + +.fa-jxl:before { + content: "\e67b"; } + +.fa-hire-a-helper:before { + content: "\f3b0"; } + +.fa-creative-commons-by:before { + content: "\f4e7"; } + +.fa-unity:before { + content: "\e049"; } + +.fa-whmcs:before { + content: "\f40d"; } + +.fa-rocketchat:before { + content: "\f3e8"; } + +.fa-vk:before { + content: "\f189"; } + +.fa-untappd:before { + content: "\f405"; } + +.fa-mailchimp:before { + content: "\f59e"; } + +.fa-css3-alt:before { + content: "\f38b"; } + +.fa-square-reddit:before { + content: "\f1a2"; } + +.fa-reddit-square:before { + content: "\f1a2"; } + +.fa-vimeo-v:before { + content: "\f27d"; } + +.fa-contao:before { + content: "\f26d"; } + +.fa-square-font-awesome:before { + content: "\e5ad"; } + +.fa-deskpro:before { + content: "\f38f"; } + +.fa-brave:before { + content: "\e63c"; } + +.fa-sistrix:before { + content: "\f3ee"; } + +.fa-square-instagram:before { + content: "\e055"; } + +.fa-instagram-square:before { + content: "\e055"; } + +.fa-battle-net:before { + content: "\f835"; } + +.fa-the-red-yeti:before { + content: "\f69d"; } + +.fa-square-hacker-news:before { + content: "\f3af"; } + +.fa-hacker-news-square:before { + content: "\f3af"; } + 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Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-comments-o:before { + content: "\f086"; } + +.fa.fa-flash:before { + content: "\f0e7"; } + +.fa.fa-clipboard:before { + content: "\f0ea"; } + +.fa.fa-lightbulb-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-lightbulb-o:before { + content: "\f0eb"; } + +.fa.fa-exchange:before { + content: "\f362"; } + +.fa.fa-cloud-download:before { + content: "\f0ed"; } + +.fa.fa-cloud-upload:before { + content: "\f0ee"; } + +.fa.fa-bell-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-bell-o:before { + content: "\f0f3"; } + +.fa.fa-cutlery:before { + content: "\f2e7"; } + +.fa.fa-file-text-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-text-o:before { + content: "\f15c"; } + +.fa.fa-building-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-building-o:before { + content: "\f1ad"; } + +.fa.fa-hospital-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-hospital-o:before { + content: "\f0f8"; } + +.fa.fa-tablet:before { + content: "\f3fa"; } + +.fa.fa-mobile:before { + content: "\f3cd"; } + +.fa.fa-mobile-phone:before { + content: "\f3cd"; } + +.fa.fa-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-circle-o:before { + content: "\f111"; } + +.fa.fa-mail-reply:before { + content: "\f3e5"; } + +.fa.fa-github-alt { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-folder-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-folder-o:before { + content: "\f07b"; } + +.fa.fa-folder-open-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-folder-open-o:before { + content: "\f07c"; } + +.fa.fa-smile-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-smile-o:before { + content: "\f118"; } + +.fa.fa-frown-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-frown-o:before { + content: "\f119"; } + +.fa.fa-meh-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-meh-o:before { + content: "\f11a"; } + +.fa.fa-keyboard-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-keyboard-o:before { + content: "\f11c"; } + +.fa.fa-flag-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-flag-o:before { + content: "\f024"; } + +.fa.fa-mail-reply-all:before { + content: "\f122"; } + +.fa.fa-star-half-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-star-half-o:before { + content: "\f5c0"; } + +.fa.fa-star-half-empty { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-star-half-empty:before { + content: "\f5c0"; } + +.fa.fa-star-half-full { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-star-half-full:before { + content: "\f5c0"; } + +.fa.fa-code-fork:before { + content: "\f126"; } + +.fa.fa-chain-broken:before { + content: "\f127"; } + +.fa.fa-unlink:before { + content: "\f127"; } + +.fa.fa-calendar-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-calendar-o:before { + content: "\f133"; } + +.fa.fa-maxcdn { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-html5 { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-css3 { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-unlock-alt:before { + content: "\f09c"; } + +.fa.fa-minus-square-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-minus-square-o:before { + content: "\f146"; } + +.fa.fa-level-up:before { + content: "\f3bf"; } + +.fa.fa-level-down:before { + content: "\f3be"; } + +.fa.fa-pencil-square:before { + content: "\f14b"; } + +.fa.fa-external-link-square:before { + content: "\f360"; } + +.fa.fa-compass { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-down { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-down:before { + content: "\f150"; } + +.fa.fa-toggle-down { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-down:before { + content: "\f150"; } + +.fa.fa-caret-square-o-up { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-up:before { + content: "\f151"; } + +.fa.fa-toggle-up { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-up:before { + content: "\f151"; } + +.fa.fa-caret-square-o-right { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-right:before { + content: "\f152"; } + +.fa.fa-toggle-right { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-right:before { + content: "\f152"; } + +.fa.fa-eur:before { + content: "\f153"; } + +.fa.fa-euro:before { + content: "\f153"; } + +.fa.fa-gbp:before { + content: "\f154"; } + +.fa.fa-usd:before { + content: "\24"; } + +.fa.fa-dollar:before { + content: "\24"; } + +.fa.fa-inr:before { + content: "\e1bc"; } + +.fa.fa-rupee:before { + content: "\e1bc"; } + +.fa.fa-jpy:before { + content: "\f157"; } + +.fa.fa-cny:before { + content: "\f157"; } + +.fa.fa-rmb:before { + content: "\f157"; } + +.fa.fa-yen:before { + content: "\f157"; } + +.fa.fa-rub:before { + content: "\f158"; } + +.fa.fa-ruble:before { + content: "\f158"; } + +.fa.fa-rouble:before { + content: "\f158"; } + +.fa.fa-krw:before { + content: "\f159"; } + +.fa.fa-won:before { + content: "\f159"; } + +.fa.fa-btc { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitcoin { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitcoin:before { + content: "\f15a"; } + +.fa.fa-file-text:before { + content: "\f15c"; } + +.fa.fa-sort-alpha-asc:before { + content: "\f15d"; } + +.fa.fa-sort-alpha-desc:before { + content: "\f881"; } + +.fa.fa-sort-amount-asc:before { + content: "\f884"; } + +.fa.fa-sort-amount-desc:before { + content: "\f160"; } + +.fa.fa-sort-numeric-asc:before { + content: "\f162"; } + +.fa.fa-sort-numeric-desc:before { + content: "\f886"; } + +.fa.fa-youtube-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-youtube-square:before { + content: "\f431"; } + +.fa.fa-youtube { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-xing { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-xing-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-xing-square:before { + content: "\f169"; } + +.fa.fa-youtube-play { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-youtube-play:before { + content: "\f167"; } + +.fa.fa-dropbox { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-stack-overflow { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-instagram { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-flickr { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-adn { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitbucket { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitbucket-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bitbucket-square:before { + content: "\f171"; } + +.fa.fa-tumblr { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-tumblr-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-tumblr-square:before { + content: "\f174"; } + +.fa.fa-long-arrow-down:before { + content: "\f309"; } + +.fa.fa-long-arrow-up:before { + content: "\f30c"; } + +.fa.fa-long-arrow-left:before { + content: "\f30a"; } + +.fa.fa-long-arrow-right:before { + content: "\f30b"; } + +.fa.fa-apple { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-windows { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-android { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-linux { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-dribbble { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-skype { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-foursquare { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-trello { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-gratipay { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-gittip { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-gittip:before { + content: "\f184"; } + +.fa.fa-sun-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-sun-o:before { + content: "\f185"; } + +.fa.fa-moon-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-moon-o:before { + content: "\f186"; } + +.fa.fa-vk { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-weibo { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-renren { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pagelines { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-stack-exchange { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-arrow-circle-o-right { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-arrow-circle-o-right:before { + content: "\f35a"; } + +.fa.fa-arrow-circle-o-left { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-arrow-circle-o-left:before { + content: "\f359"; } + +.fa.fa-caret-square-o-left { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-caret-square-o-left:before { + content: "\f191"; } + +.fa.fa-toggle-left { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-toggle-left:before { + content: "\f191"; } + +.fa.fa-dot-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-dot-circle-o:before { + content: "\f192"; } + +.fa.fa-vimeo-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-vimeo-square:before { + content: "\f194"; } + +.fa.fa-try:before { + content: "\e2bb"; } + +.fa.fa-turkish-lira:before { + content: "\e2bb"; } + +.fa.fa-plus-square-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-plus-square-o:before { + content: "\f0fe"; } + +.fa.fa-slack { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wordpress { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-openid { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-institution:before { + content: "\f19c"; } + +.fa.fa-bank:before { + content: "\f19c"; } + +.fa.fa-mortar-board:before { + content: "\f19d"; } + +.fa.fa-yahoo { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-reddit { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-reddit-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-reddit-square:before { + content: "\f1a2"; } + +.fa.fa-stumbleupon-circle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-stumbleupon { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-delicious { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-digg { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pied-piper-pp { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pied-piper-alt { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-drupal { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-joomla { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-behance { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-behance-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-behance-square:before { + content: "\f1b5"; } + +.fa.fa-steam { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-steam-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-steam-square:before { + content: "\f1b7"; } + +.fa.fa-automobile:before { + content: "\f1b9"; } + +.fa.fa-cab:before { + content: "\f1ba"; } + +.fa.fa-spotify { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-deviantart { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-soundcloud { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-file-pdf-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-pdf-o:before { + content: "\f1c1"; } + +.fa.fa-file-word-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-word-o:before { + content: "\f1c2"; } + +.fa.fa-file-excel-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-excel-o:before { + content: "\f1c3"; } + +.fa.fa-file-powerpoint-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-powerpoint-o:before { + content: "\f1c4"; } + +.fa.fa-file-image-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-image-o:before { + content: "\f1c5"; } + +.fa.fa-file-photo-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-photo-o:before { + content: "\f1c5"; } + +.fa.fa-file-picture-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-picture-o:before { + content: "\f1c5"; } + +.fa.fa-file-archive-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-archive-o:before { + content: "\f1c6"; } + +.fa.fa-file-zip-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-zip-o:before { + content: "\f1c6"; } + +.fa.fa-file-audio-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-audio-o:before { + content: "\f1c7"; } + +.fa.fa-file-sound-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-sound-o:before { + content: "\f1c7"; } + +.fa.fa-file-video-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-video-o:before { + content: "\f1c8"; } + +.fa.fa-file-movie-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-movie-o:before { + content: "\f1c8"; } + +.fa.fa-file-code-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-file-code-o:before { + content: "\f1c9"; } + +.fa.fa-vine { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-codepen { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-jsfiddle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-life-bouy:before { + content: "\f1cd"; } + +.fa.fa-life-buoy:before { + content: "\f1cd"; } + +.fa.fa-life-saver:before { + content: "\f1cd"; } + +.fa.fa-support:before { + content: "\f1cd"; } + +.fa.fa-circle-o-notch:before { + content: "\f1ce"; } + +.fa.fa-rebel { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ra { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ra:before { + content: "\f1d0"; } + +.fa.fa-resistance { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-resistance:before { + content: "\f1d0"; } + +.fa.fa-empire { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ge { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-ge:before { + content: "\f1d1"; } + +.fa.fa-git-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-git-square:before { + content: "\f1d2"; } + +.fa.fa-git { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-hacker-news { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-y-combinator-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-y-combinator-square:before { + content: "\f1d4"; } + +.fa.fa-yc-square { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-yc-square:before { + content: "\f1d4"; } + +.fa.fa-tencent-weibo { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-qq { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-weixin { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wechat { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wechat:before { + content: "\f1d7"; } + +.fa.fa-send:before { + content: "\f1d8"; } + +.fa.fa-paper-plane-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-paper-plane-o:before { + content: "\f1d8"; } + +.fa.fa-send-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-send-o:before { + content: "\f1d8"; } + +.fa.fa-circle-thin { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-circle-thin:before { + content: "\f111"; } + +.fa.fa-header:before { + content: "\f1dc"; } + +.fa.fa-futbol-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-futbol-o:before { + content: "\f1e3"; } + +.fa.fa-soccer-ball-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-soccer-ball-o:before { + content: "\f1e3"; } + +.fa.fa-slideshare { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-twitch { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-yelp { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-newspaper-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-newspaper-o:before { + content: "\f1ea"; } + +.fa.fa-paypal { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-wallet { + 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} + +.fa.fa-credit-card-alt:before { + content: "\f09d"; } + +.fa.fa-codiepie { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-modx { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-fort-awesome { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-usb { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-product-hunt { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-mixcloud { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-scribd { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-pause-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-pause-circle-o:before { + content: "\f28b"; } + +.fa.fa-stop-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-stop-circle-o:before { + content: "\f28d"; } + +.fa.fa-bluetooth { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-bluetooth-b { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-gitlab { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wpbeginner { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wpforms { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-envira { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wheelchair-alt { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wheelchair-alt:before { + content: "\f368"; } + +.fa.fa-question-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-question-circle-o:before { + content: "\f059"; } + +.fa.fa-volume-control-phone:before { + content: "\f2a0"; } + +.fa.fa-asl-interpreting:before { + content: "\f2a3"; } + +.fa.fa-deafness:before { + content: "\f2a4"; } + +.fa.fa-hard-of-hearing:before { + content: "\f2a4"; } + +.fa.fa-glide { + font-family: 'Font Awesome 6 Brands'; 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} + +.fa.fa-themeisle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-plus-official { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-plus-official:before { + content: "\f2b3"; } + +.fa.fa-google-plus-circle { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-google-plus-circle:before { + content: "\f2b3"; } + +.fa.fa-font-awesome { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-fa { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-fa:before { + content: "\f2b4"; } + +.fa.fa-handshake-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-handshake-o:before { + content: "\f2b5"; } + +.fa.fa-envelope-open-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-envelope-open-o:before { + content: "\f2b6"; } + +.fa.fa-linode { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-address-book-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-address-book-o:before { + content: "\f2b9"; } + +.fa.fa-vcard:before { + content: "\f2bb"; } + +.fa.fa-address-card-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-address-card-o:before { + content: "\f2bb"; } + +.fa.fa-vcard-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-vcard-o:before { + content: "\f2bb"; } + +.fa.fa-user-circle-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-user-circle-o:before { + content: "\f2bd"; } + +.fa.fa-user-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-user-o:before { + content: "\f007"; } + +.fa.fa-id-badge { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-drivers-license:before { + content: "\f2c2"; } + +.fa.fa-id-card-o { + font-family: 'Font Awesome 6 Free'; + font-weight: 400; } + +.fa.fa-id-card-o:before { + content: "\f2c2"; } + +.fa.fa-drivers-license-o 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content: "\f2dc"; } + +.fa.fa-superpowers { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-wpexplorer { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } + +.fa.fa-meetup { + font-family: 'Font Awesome 6 Brands'; + font-weight: 400; } diff --git a/docs/deps/font-awesome-6.5.2/css/v4-shims.min.css b/docs/deps/font-awesome-6.5.2/css/v4-shims.min.css new file mode 100644 index 00000000..09baf5fc --- /dev/null +++ b/docs/deps/font-awesome-6.5.2/css/v4-shims.min.css @@ -0,0 +1,6 @@ +/*! + * Font Awesome Free 6.5.2 by @fontawesome - https://fontawesome.com + * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) + * Copyright 2024 Fonticons, Inc. + */ +.fa.fa-glass:before{content:"\f000"}.fa.fa-envelope-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-envelope-o:before{content:"\f0e0"}.fa.fa-star-o{font-family:"Font Awesome 6 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Hide your header until you need it + * Copyright (c) 2017 Nick Williams - http://wicky.nillia.ms/headroom.js + * License: MIT + */ + +!function(a){a&&(a.fn.headroom=function(b){return this.each(function(){var c=a(this),d=c.data("headroom"),e="object"==typeof b&&b;e=a.extend(!0,{},Headroom.options,e),d||(d=new Headroom(this,e),d.init(),c.data("headroom",d)),"string"==typeof b&&(d[b](),"destroy"===b&&c.removeData("headroom"))})},a("[data-headroom]").each(function(){var b=a(this);b.headroom(b.data())}))}(window.Zepto||window.jQuery); \ No newline at end of file diff --git a/docs/deps/jquery-3.6.0/jquery-3.6.0.js b/docs/deps/jquery-3.6.0/jquery-3.6.0.js new file mode 100644 index 00000000..fc6c299b --- /dev/null +++ b/docs/deps/jquery-3.6.0/jquery-3.6.0.js @@ -0,0 +1,10881 @@ +/*! + * jQuery JavaScript Library v3.6.0 + * https://jquery.com/ + * + * Includes Sizzle.js + * https://sizzlejs.com/ + * + * Copyright OpenJS Foundation and other contributors + * Released under the MIT license + * https://jquery.org/license + * + * Date: 2021-03-02T17:08Z + */ +( function( global, factory ) { + + "use strict"; + + if ( typeof module === "object" && typeof module.exports === "object" ) { + + // For CommonJS and CommonJS-like environments where a proper `window` + // is present, execute the factory and get jQuery. + // For environments that do not have a `window` with a `document` + // (such as Node.js), expose a factory as module.exports. + // This accentuates the need for the creation of a real `window`. + // e.g. var jQuery = require("jquery")(window); + // See ticket #14549 for more info. + module.exports = global.document ? + factory( global, true ) : + function( w ) { + if ( !w.document ) { + throw new Error( "jQuery requires a window with a document" ); + } + return factory( w ); + }; + } else { + factory( global ); + } + +// Pass this if window is not defined yet +} )( typeof window !== "undefined" ? window : this, function( window, noGlobal ) { + +// Edge <= 12 - 13+, Firefox <=18 - 45+, IE 10 - 11, Safari 5.1 - 9+, iOS 6 - 9.1 +// throw exceptions when non-strict code (e.g., ASP.NET 4.5) accesses strict mode +// arguments.callee.caller (trac-13335). But as of jQuery 3.0 (2016), strict mode should be common +// enough that all such attempts are guarded in a try block. +"use strict"; + +var arr = []; + +var getProto = Object.getPrototypeOf; + +var slice = arr.slice; + +var flat = arr.flat ? function( array ) { + return arr.flat.call( array ); +} : function( array ) { + return arr.concat.apply( [], array ); +}; + + +var push = arr.push; + +var indexOf = arr.indexOf; + +var class2type = {}; + +var toString = class2type.toString; + +var hasOwn = class2type.hasOwnProperty; + +var fnToString = hasOwn.toString; + +var ObjectFunctionString = fnToString.call( Object ); + +var support = {}; + +var isFunction = function isFunction( obj ) { + + // Support: Chrome <=57, Firefox <=52 + // In some browsers, typeof returns "function" for HTML elements + // (i.e., `typeof document.createElement( "object" ) === "function"`). + // We don't want to classify *any* DOM node as a function. + // Support: QtWeb <=3.8.5, WebKit <=534.34, wkhtmltopdf tool <=0.12.5 + // Plus for old WebKit, typeof returns "function" for HTML collections + // (e.g., `typeof document.getElementsByTagName("div") === "function"`). (gh-4756) + return typeof obj === "function" && typeof obj.nodeType !== "number" && + typeof obj.item !== "function"; + }; + + +var isWindow = function isWindow( obj ) { + return obj != null && obj === obj.window; + }; + + +var document = window.document; + + + + var preservedScriptAttributes = { + type: true, + src: true, + nonce: true, + noModule: true + }; + + function DOMEval( code, node, doc ) { + doc = doc || document; + + var i, val, + script = doc.createElement( "script" ); + + script.text = code; + if ( node ) { + for ( i in preservedScriptAttributes ) { + + // Support: Firefox 64+, Edge 18+ + // Some browsers don't support the "nonce" property on scripts. + // On the other hand, just using `getAttribute` is not enough as + // the `nonce` attribute is reset to an empty string whenever it + // becomes browsing-context connected. + // See https://github.com/whatwg/html/issues/2369 + // See https://html.spec.whatwg.org/#nonce-attributes + // The `node.getAttribute` check was added for the sake of + // `jQuery.globalEval` so that it can fake a nonce-containing node + // via an object. + val = node[ i ] || node.getAttribute && node.getAttribute( i ); + if ( val ) { + script.setAttribute( i, val ); + } + } + } + doc.head.appendChild( script ).parentNode.removeChild( script ); + } + + +function toType( obj ) { + if ( obj == null ) { + return obj + ""; + } + + // Support: Android <=2.3 only (functionish RegExp) + return typeof obj === "object" || typeof obj === "function" ? + class2type[ toString.call( obj ) ] || "object" : + typeof obj; +} +/* global Symbol */ +// Defining this global in .eslintrc.json would create a danger of using the global +// unguarded in another place, it seems safer to define global only for this module + + + +var + version = "3.6.0", + + // Define a local copy of jQuery + jQuery = function( selector, context ) { + + // The jQuery object is actually just the init constructor 'enhanced' + // Need init if jQuery is called (just allow error to be thrown if not included) + return new jQuery.fn.init( selector, context ); + }; + +jQuery.fn = jQuery.prototype = { + + // The current version of jQuery being used + jquery: version, + + constructor: jQuery, + + // The default length of a jQuery object is 0 + length: 0, + + toArray: function() { + return slice.call( this ); + }, + + // Get the Nth element in the matched element set OR + // Get the whole matched element set as a clean array + get: function( num ) { + + // Return all the elements in a clean array + if ( num == null ) { + return slice.call( this ); + } + + // Return just the one element from the set + return num < 0 ? this[ num + this.length ] : this[ num ]; + }, + + // Take an array of elements and push it onto the stack + // (returning the new matched element set) + pushStack: function( elems ) { + + // Build a new jQuery matched element set + var ret = jQuery.merge( this.constructor(), elems ); + + // Add the old object onto the stack (as a reference) + ret.prevObject = this; + + // Return the newly-formed element set + return ret; + }, + + // Execute a callback for every element in the matched set. + each: function( callback ) { + return jQuery.each( this, callback ); + }, + + map: function( callback ) { + return this.pushStack( jQuery.map( this, function( elem, i ) { + return callback.call( elem, i, elem ); + } ) ); + }, + + slice: function() { + return this.pushStack( slice.apply( this, arguments ) ); + }, + + first: function() { + return this.eq( 0 ); + }, + + last: function() { + return this.eq( -1 ); + }, + + even: function() { + return this.pushStack( jQuery.grep( this, function( _elem, i ) { + return ( i + 1 ) % 2; + } ) ); + }, + + odd: function() { + return this.pushStack( jQuery.grep( this, function( _elem, i ) { + return i % 2; + } ) ); + }, + + eq: function( i ) { + var len = this.length, + j = +i + ( i < 0 ? len : 0 ); + return this.pushStack( j >= 0 && j < len ? [ this[ j ] ] : [] ); + }, + + end: function() { + return this.prevObject || this.constructor(); + }, + + // For internal use only. + // Behaves like an Array's method, not like a jQuery method. + push: push, + sort: arr.sort, + splice: arr.splice +}; + +jQuery.extend = jQuery.fn.extend = function() { + var options, name, src, copy, copyIsArray, clone, + target = arguments[ 0 ] || {}, + i = 1, + length = arguments.length, + deep = false; + + // Handle a deep copy situation + if ( typeof target === "boolean" ) { + deep = target; + + // Skip the boolean and the target + target = arguments[ i ] || {}; + i++; + } + + // Handle case when target is a string or something (possible in deep copy) + if ( typeof target !== "object" && !isFunction( target ) ) { + target = {}; + } + + // Extend jQuery itself if only one argument is passed + if ( i === length ) { + target = this; + i--; + } + + for ( ; i < length; i++ ) { + + // Only deal with non-null/undefined values + if ( ( options = arguments[ i ] ) != null ) { + + // Extend the base object + for ( name in options ) { + copy = options[ name ]; + + // Prevent Object.prototype pollution + // Prevent never-ending loop + if ( name === "__proto__" || target === copy ) { + continue; + } + + // Recurse if we're merging plain objects or arrays + if ( deep && copy && ( jQuery.isPlainObject( copy ) || + ( copyIsArray = Array.isArray( copy ) ) ) ) { + src = target[ name ]; + + // Ensure proper type for the source value + if ( copyIsArray && !Array.isArray( src ) ) { + clone = []; + } else if ( !copyIsArray && !jQuery.isPlainObject( src ) ) { + clone = {}; + } else { + clone = src; + } + copyIsArray = false; + + // Never move original objects, clone them + target[ name ] = jQuery.extend( deep, clone, copy ); + + // Don't bring in undefined values + } else if ( copy !== undefined ) { + target[ name ] = copy; + } + } + } + } + + // Return the modified object + return target; +}; + +jQuery.extend( { + + // Unique for each copy of jQuery on the page + expando: "jQuery" + ( version + Math.random() ).replace( /\D/g, "" ), + + // Assume jQuery is ready without the ready module + isReady: true, + + error: function( msg ) { + throw new Error( msg ); + }, + + noop: function() {}, + + isPlainObject: function( obj ) { + var proto, Ctor; + + // Detect obvious negatives + // Use toString instead of jQuery.type to catch host objects + if ( !obj || toString.call( obj ) !== "[object Object]" ) { + return false; + } + + proto = getProto( obj ); + + // Objects with no prototype (e.g., `Object.create( null )`) are plain + if ( !proto ) { + return true; + } + + // Objects with prototype are plain iff they were constructed by a global Object function + Ctor = hasOwn.call( proto, "constructor" ) && proto.constructor; + return typeof Ctor === "function" && fnToString.call( Ctor ) === ObjectFunctionString; + }, + + isEmptyObject: function( obj ) { + var name; + + for ( name in obj ) { + return false; + } + return true; + }, + + // Evaluates a script in a provided context; falls back to the global one + // if not specified. + globalEval: function( code, options, doc ) { + DOMEval( code, { nonce: options && options.nonce }, doc ); + }, + + each: function( obj, callback ) { + var length, i = 0; + + if ( isArrayLike( obj ) ) { + length = obj.length; + for ( ; i < length; i++ ) { + if ( callback.call( obj[ i ], i, obj[ i ] ) === false ) { + break; + } + } + } else { + for ( i in obj ) { + if ( callback.call( obj[ i ], i, obj[ i ] ) === false ) { + break; + } + } + } + + return obj; + }, + + // results is for internal usage only + makeArray: function( arr, results ) { + var ret = results || []; + + if ( arr != null ) { + if ( isArrayLike( Object( arr ) ) ) { + jQuery.merge( ret, + typeof arr === "string" ? + [ arr ] : arr + ); + } else { + push.call( ret, arr ); + } + } + + return ret; + }, + + inArray: function( elem, arr, i ) { + return arr == null ? -1 : indexOf.call( arr, elem, i ); + }, + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + merge: function( first, second ) { + var len = +second.length, + j = 0, + i = first.length; + + for ( ; j < len; j++ ) { + first[ i++ ] = second[ j ]; + } + + first.length = i; + + return first; + }, + + grep: function( elems, callback, invert ) { + var callbackInverse, + matches = [], + i = 0, + length = elems.length, + callbackExpect = !invert; + + // Go through the array, only saving the items + // that pass the validator function + for ( ; i < length; i++ ) { + callbackInverse = !callback( elems[ i ], i ); + if ( callbackInverse !== callbackExpect ) { + matches.push( elems[ i ] ); + } + } + + return matches; + }, + + // arg is for internal usage only + map: function( elems, callback, arg ) { + var length, value, + i = 0, + ret = []; + + // Go through the array, translating each of the items to their new values + if ( isArrayLike( elems ) ) { + length = elems.length; + for ( ; i < length; i++ ) { + value = callback( elems[ i ], i, arg ); + + if ( value != null ) { + ret.push( value ); + } + } + + // Go through every key on the object, + } else { + for ( i in elems ) { + value = callback( elems[ i ], i, arg ); + + if ( value != null ) { + ret.push( value ); + } + } + } + + // Flatten any nested arrays + return flat( ret ); + }, + + // A global GUID counter for objects + guid: 1, + + // jQuery.support is not used in Core but other projects attach their + // properties to it so it needs to exist. + support: support +} ); + +if ( typeof Symbol === "function" ) { + jQuery.fn[ Symbol.iterator ] = arr[ Symbol.iterator ]; +} + +// Populate the class2type map +jQuery.each( "Boolean Number String Function Array Date RegExp Object Error Symbol".split( " " ), + function( _i, name ) { + class2type[ "[object " + name + "]" ] = name.toLowerCase(); + } ); + +function isArrayLike( obj ) { + + // Support: real iOS 8.2 only (not reproducible in simulator) + // `in` check used to prevent JIT error (gh-2145) + // hasOwn isn't used here due to false negatives + // regarding Nodelist length in IE + var length = !!obj && "length" in obj && obj.length, + type = toType( obj ); + + if ( isFunction( obj ) || isWindow( obj ) ) { + return false; + } + + return type === "array" || length === 0 || + typeof length === "number" && length > 0 && ( length - 1 ) in obj; +} +var Sizzle = +/*! + * Sizzle CSS Selector Engine v2.3.6 + * https://sizzlejs.com/ + * + * Copyright JS Foundation and other contributors + * Released under the MIT license + * https://js.foundation/ + * + * Date: 2021-02-16 + */ +( function( window ) { +var i, + support, + Expr, + getText, + isXML, + tokenize, + compile, + select, + outermostContext, + sortInput, + hasDuplicate, + + // Local document vars + setDocument, + document, + docElem, + documentIsHTML, + rbuggyQSA, + rbuggyMatches, + matches, + contains, + + // Instance-specific data + expando = "sizzle" + 1 * new Date(), + preferredDoc = window.document, + dirruns = 0, + done = 0, + classCache = createCache(), + tokenCache = createCache(), + compilerCache = createCache(), + nonnativeSelectorCache = createCache(), + sortOrder = function( a, b ) { + if ( a === b ) { + hasDuplicate = true; + } + return 0; + }, + + // Instance methods + hasOwn = ( {} ).hasOwnProperty, + arr = [], + pop = arr.pop, + pushNative = arr.push, + push = arr.push, + slice = arr.slice, + + // Use a stripped-down indexOf as it's faster than native + // https://jsperf.com/thor-indexof-vs-for/5 + indexOf = function( list, elem ) { + var i = 0, + len = list.length; + for ( ; i < len; i++ ) { + if ( list[ i ] === elem ) { + return i; + } + } + return -1; + }, + + booleans = "checked|selected|async|autofocus|autoplay|controls|defer|disabled|hidden|" + + "ismap|loop|multiple|open|readonly|required|scoped", + + // Regular expressions + + // http://www.w3.org/TR/css3-selectors/#whitespace + whitespace = "[\\x20\\t\\r\\n\\f]", + + // https://www.w3.org/TR/css-syntax-3/#ident-token-diagram + identifier = "(?:\\\\[\\da-fA-F]{1,6}" + whitespace + + "?|\\\\[^\\r\\n\\f]|[\\w-]|[^\0-\\x7f])+", + + // Attribute selectors: http://www.w3.org/TR/selectors/#attribute-selectors + attributes = "\\[" + whitespace + "*(" + identifier + ")(?:" + whitespace + + + // Operator (capture 2) + "*([*^$|!~]?=)" + whitespace + + + // "Attribute values must be CSS identifiers [capture 5] + // or strings [capture 3 or capture 4]" + "*(?:'((?:\\\\.|[^\\\\'])*)'|\"((?:\\\\.|[^\\\\\"])*)\"|(" + identifier + "))|)" + + whitespace + "*\\]", + + pseudos = ":(" + identifier + ")(?:\\((" + + + // To reduce the number of selectors needing tokenize in the preFilter, prefer arguments: + // 1. quoted (capture 3; capture 4 or capture 5) + "('((?:\\\\.|[^\\\\'])*)'|\"((?:\\\\.|[^\\\\\"])*)\")|" + + + // 2. simple (capture 6) + "((?:\\\\.|[^\\\\()[\\]]|" + attributes + ")*)|" + + + // 3. anything else (capture 2) + ".*" + + ")\\)|)", + + // Leading and non-escaped trailing whitespace, capturing some non-whitespace characters preceding the latter + rwhitespace = new RegExp( whitespace + "+", "g" ), + rtrim = new RegExp( "^" + whitespace + "+|((?:^|[^\\\\])(?:\\\\.)*)" + + whitespace + "+$", "g" ), + + rcomma = new RegExp( "^" + whitespace + "*," + whitespace + "*" ), + rcombinators = new RegExp( "^" + whitespace + "*([>+~]|" + whitespace + ")" + whitespace + + "*" ), + rdescend = new RegExp( whitespace + "|>" ), + + rpseudo = new RegExp( pseudos ), + ridentifier = new RegExp( "^" + identifier + "$" ), + + matchExpr = { + "ID": new RegExp( "^#(" + identifier + ")" ), + "CLASS": new RegExp( "^\\.(" + identifier + ")" ), + "TAG": new RegExp( "^(" + identifier + "|[*])" ), + "ATTR": new RegExp( "^" + attributes ), + "PSEUDO": new RegExp( "^" + pseudos ), + "CHILD": new RegExp( "^:(only|first|last|nth|nth-last)-(child|of-type)(?:\\(" + + whitespace + "*(even|odd|(([+-]|)(\\d*)n|)" + whitespace + "*(?:([+-]|)" + + whitespace + "*(\\d+)|))" + whitespace + "*\\)|)", "i" ), + "bool": new RegExp( "^(?:" + booleans + ")$", "i" ), + + // For use in libraries implementing .is() + // We use this for POS matching in `select` + "needsContext": new RegExp( "^" + whitespace + + "*[>+~]|:(even|odd|eq|gt|lt|nth|first|last)(?:\\(" + whitespace + + "*((?:-\\d)?\\d*)" + whitespace + "*\\)|)(?=[^-]|$)", "i" ) + }, + + rhtml = /HTML$/i, + rinputs = /^(?:input|select|textarea|button)$/i, + rheader = /^h\d$/i, + + rnative = /^[^{]+\{\s*\[native \w/, + + // Easily-parseable/retrievable ID or TAG or CLASS selectors + rquickExpr = /^(?:#([\w-]+)|(\w+)|\.([\w-]+))$/, + + rsibling = /[+~]/, + + // CSS escapes + // http://www.w3.org/TR/CSS21/syndata.html#escaped-characters + runescape = new RegExp( "\\\\[\\da-fA-F]{1,6}" + whitespace + "?|\\\\([^\\r\\n\\f])", "g" ), + funescape = function( escape, nonHex ) { + var high = "0x" + escape.slice( 1 ) - 0x10000; + + return nonHex ? + + // Strip the backslash prefix from a non-hex escape sequence + nonHex : + + // Replace a hexadecimal escape sequence with the encoded Unicode code point + // Support: IE <=11+ + // For values outside the Basic Multilingual Plane (BMP), manually construct a + // surrogate pair + high < 0 ? + String.fromCharCode( high + 0x10000 ) : + String.fromCharCode( high >> 10 | 0xD800, high & 0x3FF | 0xDC00 ); + }, + + // CSS string/identifier serialization + // https://drafts.csswg.org/cssom/#common-serializing-idioms + rcssescape = /([\0-\x1f\x7f]|^-?\d)|^-$|[^\0-\x1f\x7f-\uFFFF\w-]/g, + fcssescape = function( ch, asCodePoint ) { + if ( asCodePoint ) { + + // U+0000 NULL becomes U+FFFD REPLACEMENT CHARACTER + if ( ch === "\0" ) { + return "\uFFFD"; + } + + // Control characters and (dependent upon position) numbers get escaped as code points + return ch.slice( 0, -1 ) + "\\" + + ch.charCodeAt( ch.length - 1 ).toString( 16 ) + " "; + } + + // Other potentially-special ASCII characters get backslash-escaped + return "\\" + ch; + }, + + // Used for iframes + // See setDocument() + // Removing the function wrapper causes a "Permission Denied" + // error in IE + unloadHandler = function() { + setDocument(); + }, + + inDisabledFieldset = addCombinator( + function( elem ) { + return elem.disabled === true && elem.nodeName.toLowerCase() === "fieldset"; + }, + { dir: "parentNode", next: "legend" } + ); + +// Optimize for push.apply( _, NodeList ) +try { + push.apply( + ( arr = slice.call( preferredDoc.childNodes ) ), + preferredDoc.childNodes + ); + + // Support: Android<4.0 + // Detect silently failing push.apply + // eslint-disable-next-line no-unused-expressions + arr[ preferredDoc.childNodes.length ].nodeType; +} catch ( e ) { + push = { apply: arr.length ? + + // Leverage slice if possible + function( target, els ) { + pushNative.apply( target, slice.call( els ) ); + } : + + // Support: IE<9 + // Otherwise append directly + function( target, els ) { + var j = target.length, + i = 0; + + // Can't trust NodeList.length + while ( ( target[ j++ ] = els[ i++ ] ) ) {} + target.length = j - 1; + } + }; +} + +function Sizzle( selector, context, results, seed ) { + var m, i, elem, nid, match, groups, newSelector, + newContext = context && context.ownerDocument, + + // nodeType defaults to 9, since context defaults to document + nodeType = context ? context.nodeType : 9; + + results = results || []; + + // Return early from calls with invalid selector or context + if ( typeof selector !== "string" || !selector || + nodeType !== 1 && nodeType !== 9 && nodeType !== 11 ) { + + return results; + } + + // Try to shortcut find operations (as opposed to filters) in HTML documents + if ( !seed ) { + setDocument( context ); + context = context || document; + + if ( documentIsHTML ) { + + // If the selector is sufficiently simple, try using a "get*By*" DOM method + // (excepting DocumentFragment context, where the methods don't exist) + if ( nodeType !== 11 && ( match = rquickExpr.exec( selector ) ) ) { + + // ID selector + if ( ( m = match[ 1 ] ) ) { + + // Document context + if ( nodeType === 9 ) { + if ( ( elem = context.getElementById( m ) ) ) { + + // Support: IE, Opera, Webkit + // TODO: identify versions + // getElementById can match elements by name instead of ID + if ( elem.id === m ) { + results.push( elem ); + return results; + } + } else { + return results; + } + + // Element context + } else { + + // Support: IE, Opera, Webkit + // TODO: identify versions + // getElementById can match elements by name instead of ID + if ( newContext && ( elem = newContext.getElementById( m ) ) && + contains( context, elem ) && + elem.id === m ) { + + results.push( elem ); + return results; + } + } + + // Type selector + } else if ( match[ 2 ] ) { + push.apply( results, context.getElementsByTagName( selector ) ); + return results; + + // Class selector + } else if ( ( m = match[ 3 ] ) && support.getElementsByClassName && + context.getElementsByClassName ) { + + push.apply( results, context.getElementsByClassName( m ) ); + return results; + } + } + + // Take advantage of querySelectorAll + if ( support.qsa && + !nonnativeSelectorCache[ selector + " " ] && + ( !rbuggyQSA || !rbuggyQSA.test( selector ) ) && + + // Support: IE 8 only + // Exclude object elements + ( nodeType !== 1 || context.nodeName.toLowerCase() !== "object" ) ) { + + newSelector = selector; + newContext = context; + + // qSA considers elements outside a scoping root when evaluating child or + // descendant combinators, which is not what we want. + // In such cases, we work around the behavior by prefixing every selector in the + // list with an ID selector referencing the scope context. + // The technique has to be used as well when a leading combinator is used + // as such selectors are not recognized by querySelectorAll. + // Thanks to Andrew Dupont for this technique. + if ( nodeType === 1 && + ( rdescend.test( selector ) || rcombinators.test( selector ) ) ) { + + // Expand context for sibling selectors + newContext = rsibling.test( selector ) && testContext( context.parentNode ) || + context; + + // We can use :scope instead of the ID hack if the browser + // supports it & if we're not changing the context. + if ( newContext !== context || !support.scope ) { + + // Capture the context ID, setting it first if necessary + if ( ( nid = context.getAttribute( "id" ) ) ) { + nid = nid.replace( rcssescape, fcssescape ); + } else { + context.setAttribute( "id", ( nid = expando ) ); + } + } + + // Prefix every selector in the list + groups = tokenize( selector ); + i = groups.length; + while ( i-- ) { + groups[ i ] = ( nid ? "#" + nid : ":scope" ) + " " + + toSelector( groups[ i ] ); + } + newSelector = groups.join( "," ); + } + + try { + push.apply( results, + newContext.querySelectorAll( newSelector ) + ); + return results; + } catch ( qsaError ) { + nonnativeSelectorCache( selector, true ); + } finally { + if ( nid === expando ) { + context.removeAttribute( "id" ); + } + } + } + } + } + + // All others + return select( selector.replace( rtrim, "$1" ), context, results, seed ); +} + +/** + * Create key-value caches of limited size + * @returns {function(string, object)} Returns the Object data after storing it on itself with + * property name the (space-suffixed) string and (if the cache is larger than Expr.cacheLength) + * deleting the oldest entry + */ +function createCache() { + var keys = []; + + function cache( key, value ) { + + // Use (key + " ") to avoid collision with native prototype properties (see Issue #157) + if ( keys.push( key + " " ) > Expr.cacheLength ) { + + // Only keep the most recent entries + delete cache[ keys.shift() ]; + } + return ( cache[ key + " " ] = value ); + } + return cache; +} + +/** + * Mark a function for special use by Sizzle + * @param {Function} fn The function to mark + */ +function markFunction( fn ) { + fn[ expando ] = true; + return fn; +} + +/** + * Support testing using an element + * @param {Function} fn Passed the created element and returns a boolean result + */ +function assert( fn ) { + var el = document.createElement( "fieldset" ); + + try { + return !!fn( el ); + } catch ( e ) { + return false; + } finally { + + // Remove from its parent by default + if ( el.parentNode ) { + el.parentNode.removeChild( el ); + } + + // release memory in IE + el = null; + } +} + +/** + * Adds the same handler for all of the specified attrs + * @param {String} attrs Pipe-separated list of attributes + * @param {Function} handler The method that will be applied + */ +function addHandle( attrs, handler ) { + var arr = attrs.split( "|" ), + i = arr.length; + + while ( i-- ) { + Expr.attrHandle[ arr[ i ] ] = handler; + } +} + +/** + * Checks document order of two siblings + * @param {Element} a + * @param {Element} b + * @returns {Number} Returns less than 0 if a precedes b, greater than 0 if a follows b + */ +function siblingCheck( a, b ) { + var cur = b && a, + diff = cur && a.nodeType === 1 && b.nodeType === 1 && + a.sourceIndex - b.sourceIndex; + + // Use IE sourceIndex if available on both nodes + if ( diff ) { + return diff; + } + + // Check if b follows a + if ( cur ) { + while ( ( cur = cur.nextSibling ) ) { + if ( cur === b ) { + return -1; + } + } + } + + return a ? 1 : -1; +} + +/** + * Returns a function to use in pseudos for input types + * @param {String} type + */ +function createInputPseudo( type ) { + return function( elem ) { + var name = elem.nodeName.toLowerCase(); + return name === "input" && elem.type === type; + }; +} + +/** + * Returns a function to use in pseudos for buttons + * @param {String} type + */ +function createButtonPseudo( type ) { + return function( elem ) { + var name = elem.nodeName.toLowerCase(); + return ( name === "input" || name === "button" ) && elem.type === type; + }; +} + +/** + * Returns a function to use in pseudos for :enabled/:disabled + * @param {Boolean} disabled true for :disabled; false for :enabled + */ +function createDisabledPseudo( disabled ) { + + // Known :disabled false positives: fieldset[disabled] > legend:nth-of-type(n+2) :can-disable + return function( elem ) { + + // Only certain elements can match :enabled or :disabled + // https://html.spec.whatwg.org/multipage/scripting.html#selector-enabled + // https://html.spec.whatwg.org/multipage/scripting.html#selector-disabled + if ( "form" in elem ) { + + // Check for inherited disabledness on relevant non-disabled elements: + // * listed form-associated elements in a disabled fieldset + // https://html.spec.whatwg.org/multipage/forms.html#category-listed + // https://html.spec.whatwg.org/multipage/forms.html#concept-fe-disabled + // * option elements in a disabled optgroup + // https://html.spec.whatwg.org/multipage/forms.html#concept-option-disabled + // All such elements have a "form" property. + if ( elem.parentNode && elem.disabled === false ) { + + // Option elements defer to a parent optgroup if present + if ( "label" in elem ) { + if ( "label" in elem.parentNode ) { + return elem.parentNode.disabled === disabled; + } else { + return elem.disabled === disabled; + } + } + + // Support: IE 6 - 11 + // Use the isDisabled shortcut property to check for disabled fieldset ancestors + return elem.isDisabled === disabled || + + // Where there is no isDisabled, check manually + /* jshint -W018 */ + elem.isDisabled !== !disabled && + inDisabledFieldset( elem ) === disabled; + } + + return elem.disabled === disabled; + + // Try to winnow out elements that can't be disabled before trusting the disabled property. + // Some victims get caught in our net (label, legend, menu, track), but it shouldn't + // even exist on them, let alone have a boolean value. + } else if ( "label" in elem ) { + return elem.disabled === disabled; + } + + // Remaining elements are neither :enabled nor :disabled + return false; + }; +} + +/** + * Returns a function to use in pseudos for positionals + * @param {Function} fn + */ +function createPositionalPseudo( fn ) { + return markFunction( function( argument ) { + argument = +argument; + return markFunction( function( seed, matches ) { + var j, + matchIndexes = fn( [], seed.length, argument ), + i = matchIndexes.length; + + // Match elements found at the specified indexes + while ( i-- ) { + if ( seed[ ( j = matchIndexes[ i ] ) ] ) { + seed[ j ] = !( matches[ j ] = seed[ j ] ); + } + } + } ); + } ); +} + +/** + * Checks a node for validity as a Sizzle context + * @param {Element|Object=} context + * @returns {Element|Object|Boolean} The input node if acceptable, otherwise a falsy value + */ +function testContext( context ) { + return context && typeof context.getElementsByTagName !== "undefined" && context; +} + +// Expose support vars for convenience +support = Sizzle.support = {}; + +/** + * Detects XML nodes + * @param {Element|Object} elem An element or a document + * @returns {Boolean} True iff elem is a non-HTML XML node + */ +isXML = Sizzle.isXML = function( elem ) { + var namespace = elem && elem.namespaceURI, + docElem = elem && ( elem.ownerDocument || elem ).documentElement; + + // Support: IE <=8 + // Assume HTML when documentElement doesn't yet exist, such as inside loading iframes + // https://bugs.jquery.com/ticket/4833 + return !rhtml.test( namespace || docElem && docElem.nodeName || "HTML" ); +}; + +/** + * Sets document-related variables once based on the current document + * @param {Element|Object} [doc] An element or document object to use to set the document + * @returns {Object} Returns the current document + */ +setDocument = Sizzle.setDocument = function( node ) { + var hasCompare, subWindow, + doc = node ? node.ownerDocument || node : preferredDoc; + + // Return early if doc is invalid or already selected + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( doc == document || doc.nodeType !== 9 || !doc.documentElement ) { + return document; + } + + // Update global variables + document = doc; + docElem = document.documentElement; + documentIsHTML = !isXML( document ); + + // Support: IE 9 - 11+, Edge 12 - 18+ + // Accessing iframe documents after unload throws "permission denied" errors (jQuery #13936) + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( preferredDoc != document && + ( subWindow = document.defaultView ) && subWindow.top !== subWindow ) { + + // Support: IE 11, Edge + if ( subWindow.addEventListener ) { + subWindow.addEventListener( "unload", unloadHandler, false ); + + // Support: IE 9 - 10 only + } else if ( subWindow.attachEvent ) { + subWindow.attachEvent( "onunload", unloadHandler ); + } + } + + // Support: IE 8 - 11+, Edge 12 - 18+, Chrome <=16 - 25 only, Firefox <=3.6 - 31 only, + // Safari 4 - 5 only, Opera <=11.6 - 12.x only + // IE/Edge & older browsers don't support the :scope pseudo-class. + // Support: Safari 6.0 only + // Safari 6.0 supports :scope but it's an alias of :root there. + support.scope = assert( function( el ) { + docElem.appendChild( el ).appendChild( document.createElement( "div" ) ); + return typeof el.querySelectorAll !== "undefined" && + !el.querySelectorAll( ":scope fieldset div" ).length; + } ); + + /* Attributes + ---------------------------------------------------------------------- */ + + // Support: IE<8 + // Verify that getAttribute really returns attributes and not properties + // (excepting IE8 booleans) + support.attributes = assert( function( el ) { + el.className = "i"; + return !el.getAttribute( "className" ); + } ); + + /* getElement(s)By* + ---------------------------------------------------------------------- */ + + // Check if getElementsByTagName("*") returns only elements + support.getElementsByTagName = assert( function( el ) { + el.appendChild( document.createComment( "" ) ); + return !el.getElementsByTagName( "*" ).length; + } ); + + // Support: IE<9 + support.getElementsByClassName = rnative.test( document.getElementsByClassName ); + + // Support: IE<10 + // Check if getElementById returns elements by name + // The broken getElementById methods don't pick up programmatically-set names, + // so use a roundabout getElementsByName test + support.getById = assert( function( el ) { + docElem.appendChild( el ).id = expando; + return !document.getElementsByName || !document.getElementsByName( expando ).length; + } ); + + // ID filter and find + if ( support.getById ) { + Expr.filter[ "ID" ] = function( id ) { + var attrId = id.replace( runescape, funescape ); + return function( elem ) { + return elem.getAttribute( "id" ) === attrId; + }; + }; + Expr.find[ "ID" ] = function( id, context ) { + if ( typeof context.getElementById !== "undefined" && documentIsHTML ) { + var elem = context.getElementById( id ); + return elem ? [ elem ] : []; + } + }; + } else { + Expr.filter[ "ID" ] = function( id ) { + var attrId = id.replace( runescape, funescape ); + return function( elem ) { + var node = typeof elem.getAttributeNode !== "undefined" && + elem.getAttributeNode( "id" ); + return node && node.value === attrId; + }; + }; + + // Support: IE 6 - 7 only + // getElementById is not reliable as a find shortcut + Expr.find[ "ID" ] = function( id, context ) { + if ( typeof context.getElementById !== "undefined" && documentIsHTML ) { + var node, i, elems, + elem = context.getElementById( id ); + + if ( elem ) { + + // Verify the id attribute + node = elem.getAttributeNode( "id" ); + if ( node && node.value === id ) { + return [ elem ]; + } + + // Fall back on getElementsByName + elems = context.getElementsByName( id ); + i = 0; + while ( ( elem = elems[ i++ ] ) ) { + node = elem.getAttributeNode( "id" ); + if ( node && node.value === id ) { + return [ elem ]; + } + } + } + + return []; + } + }; + } + + // Tag + Expr.find[ "TAG" ] = support.getElementsByTagName ? + function( tag, context ) { + if ( typeof context.getElementsByTagName !== "undefined" ) { + return context.getElementsByTagName( tag ); + + // DocumentFragment nodes don't have gEBTN + } else if ( support.qsa ) { + return context.querySelectorAll( tag ); + } + } : + + function( tag, context ) { + var elem, + tmp = [], + i = 0, + + // By happy coincidence, a (broken) gEBTN appears on DocumentFragment nodes too + results = context.getElementsByTagName( tag ); + + // Filter out possible comments + if ( tag === "*" ) { + while ( ( elem = results[ i++ ] ) ) { + if ( elem.nodeType === 1 ) { + tmp.push( elem ); + } + } + + return tmp; + } + return results; + }; + + // Class + Expr.find[ "CLASS" ] = support.getElementsByClassName && function( className, context ) { + if ( typeof context.getElementsByClassName !== "undefined" && documentIsHTML ) { + return context.getElementsByClassName( className ); + } + }; + + /* QSA/matchesSelector + ---------------------------------------------------------------------- */ + + // QSA and matchesSelector support + + // matchesSelector(:active) reports false when true (IE9/Opera 11.5) + rbuggyMatches = []; + + // qSa(:focus) reports false when true (Chrome 21) + // We allow this because of a bug in IE8/9 that throws an error + // whenever `document.activeElement` is accessed on an iframe + // So, we allow :focus to pass through QSA all the time to avoid the IE error + // See https://bugs.jquery.com/ticket/13378 + rbuggyQSA = []; + + if ( ( support.qsa = rnative.test( document.querySelectorAll ) ) ) { + + // Build QSA regex + // Regex strategy adopted from Diego Perini + assert( function( el ) { + + var input; + + // Select is set to empty string on purpose + // This is to test IE's treatment of not explicitly + // setting a boolean content attribute, + // since its presence should be enough + // https://bugs.jquery.com/ticket/12359 + docElem.appendChild( el ).innerHTML = "" + + ""; + + // Support: IE8, Opera 11-12.16 + // Nothing should be selected when empty strings follow ^= or $= or *= + // The test attribute must be unknown in Opera but "safe" for WinRT + // https://msdn.microsoft.com/en-us/library/ie/hh465388.aspx#attribute_section + if ( el.querySelectorAll( "[msallowcapture^='']" ).length ) { + rbuggyQSA.push( "[*^$]=" + whitespace + "*(?:''|\"\")" ); + } + + // Support: IE8 + // Boolean attributes and "value" are not treated correctly + if ( !el.querySelectorAll( "[selected]" ).length ) { + rbuggyQSA.push( "\\[" + whitespace + "*(?:value|" + booleans + ")" ); + } + + // Support: Chrome<29, Android<4.4, Safari<7.0+, iOS<7.0+, PhantomJS<1.9.8+ + if ( !el.querySelectorAll( "[id~=" + expando + "-]" ).length ) { + rbuggyQSA.push( "~=" ); + } + + // Support: IE 11+, Edge 15 - 18+ + // IE 11/Edge don't find elements on a `[name='']` query in some cases. + // Adding a temporary attribute to the document before the selection works + // around the issue. + // Interestingly, IE 10 & older don't seem to have the issue. + input = document.createElement( "input" ); + input.setAttribute( "name", "" ); + el.appendChild( input ); + if ( !el.querySelectorAll( "[name='']" ).length ) { + rbuggyQSA.push( "\\[" + whitespace + "*name" + whitespace + "*=" + + whitespace + "*(?:''|\"\")" ); + } + + // Webkit/Opera - :checked should return selected option elements + // http://www.w3.org/TR/2011/REC-css3-selectors-20110929/#checked + // IE8 throws error here and will not see later tests + if ( !el.querySelectorAll( ":checked" ).length ) { + rbuggyQSA.push( ":checked" ); + } + + // Support: Safari 8+, iOS 8+ + // https://bugs.webkit.org/show_bug.cgi?id=136851 + // In-page `selector#id sibling-combinator selector` fails + if ( !el.querySelectorAll( "a#" + expando + "+*" ).length ) { + rbuggyQSA.push( ".#.+[+~]" ); + } + + // Support: Firefox <=3.6 - 5 only + // Old Firefox doesn't throw on a badly-escaped identifier. + el.querySelectorAll( "\\\f" ); + rbuggyQSA.push( "[\\r\\n\\f]" ); + } ); + + assert( function( el ) { + el.innerHTML = "" + + ""; + + // Support: Windows 8 Native Apps + // The type and name attributes are restricted during .innerHTML assignment + var input = document.createElement( "input" ); + input.setAttribute( "type", "hidden" ); + el.appendChild( input ).setAttribute( "name", "D" ); + + // Support: IE8 + // Enforce case-sensitivity of name attribute + if ( el.querySelectorAll( "[name=d]" ).length ) { + rbuggyQSA.push( "name" + whitespace + "*[*^$|!~]?=" ); + } + + // FF 3.5 - :enabled/:disabled and hidden elements (hidden elements are still enabled) + // IE8 throws error here and will not see later tests + if ( el.querySelectorAll( ":enabled" ).length !== 2 ) { + rbuggyQSA.push( ":enabled", ":disabled" ); + } + + // Support: IE9-11+ + // IE's :disabled selector does not pick up the children of disabled fieldsets + docElem.appendChild( el ).disabled = true; + if ( el.querySelectorAll( ":disabled" ).length !== 2 ) { + rbuggyQSA.push( ":enabled", ":disabled" ); + } + + // Support: Opera 10 - 11 only + // Opera 10-11 does not throw on post-comma invalid pseudos + el.querySelectorAll( "*,:x" ); + rbuggyQSA.push( ",.*:" ); + } ); + } + + if ( ( support.matchesSelector = rnative.test( ( matches = docElem.matches || + docElem.webkitMatchesSelector || + docElem.mozMatchesSelector || + docElem.oMatchesSelector || + docElem.msMatchesSelector ) ) ) ) { + + assert( function( el ) { + + // Check to see if it's possible to do matchesSelector + // on a disconnected node (IE 9) + support.disconnectedMatch = matches.call( el, "*" ); + + // This should fail with an exception + // Gecko does not error, returns false instead + matches.call( el, "[s!='']:x" ); + rbuggyMatches.push( "!=", pseudos ); + } ); + } + + rbuggyQSA = rbuggyQSA.length && new RegExp( rbuggyQSA.join( "|" ) ); + rbuggyMatches = rbuggyMatches.length && new RegExp( rbuggyMatches.join( "|" ) ); + + /* Contains + ---------------------------------------------------------------------- */ + hasCompare = rnative.test( docElem.compareDocumentPosition ); + + // Element contains another + // Purposefully self-exclusive + // As in, an element does not contain itself + contains = hasCompare || rnative.test( docElem.contains ) ? + function( a, b ) { + var adown = a.nodeType === 9 ? a.documentElement : a, + bup = b && b.parentNode; + return a === bup || !!( bup && bup.nodeType === 1 && ( + adown.contains ? + adown.contains( bup ) : + a.compareDocumentPosition && a.compareDocumentPosition( bup ) & 16 + ) ); + } : + function( a, b ) { + if ( b ) { + while ( ( b = b.parentNode ) ) { + if ( b === a ) { + return true; + } + } + } + return false; + }; + + /* Sorting + ---------------------------------------------------------------------- */ + + // Document order sorting + sortOrder = hasCompare ? + function( a, b ) { + + // Flag for duplicate removal + if ( a === b ) { + hasDuplicate = true; + return 0; + } + + // Sort on method existence if only one input has compareDocumentPosition + var compare = !a.compareDocumentPosition - !b.compareDocumentPosition; + if ( compare ) { + return compare; + } + + // Calculate position if both inputs belong to the same document + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + compare = ( a.ownerDocument || a ) == ( b.ownerDocument || b ) ? + a.compareDocumentPosition( b ) : + + // Otherwise we know they are disconnected + 1; + + // Disconnected nodes + if ( compare & 1 || + ( !support.sortDetached && b.compareDocumentPosition( a ) === compare ) ) { + + // Choose the first element that is related to our preferred document + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( a == document || a.ownerDocument == preferredDoc && + contains( preferredDoc, a ) ) { + return -1; + } + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( b == document || b.ownerDocument == preferredDoc && + contains( preferredDoc, b ) ) { + return 1; + } + + // Maintain original order + return sortInput ? + ( indexOf( sortInput, a ) - indexOf( sortInput, b ) ) : + 0; + } + + return compare & 4 ? -1 : 1; + } : + function( a, b ) { + + // Exit early if the nodes are identical + if ( a === b ) { + hasDuplicate = true; + return 0; + } + + var cur, + i = 0, + aup = a.parentNode, + bup = b.parentNode, + ap = [ a ], + bp = [ b ]; + + // Parentless nodes are either documents or disconnected + if ( !aup || !bup ) { + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + /* eslint-disable eqeqeq */ + return a == document ? -1 : + b == document ? 1 : + /* eslint-enable eqeqeq */ + aup ? -1 : + bup ? 1 : + sortInput ? + ( indexOf( sortInput, a ) - indexOf( sortInput, b ) ) : + 0; + + // If the nodes are siblings, we can do a quick check + } else if ( aup === bup ) { + return siblingCheck( a, b ); + } + + // Otherwise we need full lists of their ancestors for comparison + cur = a; + while ( ( cur = cur.parentNode ) ) { + ap.unshift( cur ); + } + cur = b; + while ( ( cur = cur.parentNode ) ) { + bp.unshift( cur ); + } + + // Walk down the tree looking for a discrepancy + while ( ap[ i ] === bp[ i ] ) { + i++; + } + + return i ? + + // Do a sibling check if the nodes have a common ancestor + siblingCheck( ap[ i ], bp[ i ] ) : + + // Otherwise nodes in our document sort first + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + /* eslint-disable eqeqeq */ + ap[ i ] == preferredDoc ? -1 : + bp[ i ] == preferredDoc ? 1 : + /* eslint-enable eqeqeq */ + 0; + }; + + return document; +}; + +Sizzle.matches = function( expr, elements ) { + return Sizzle( expr, null, null, elements ); +}; + +Sizzle.matchesSelector = function( elem, expr ) { + setDocument( elem ); + + if ( support.matchesSelector && documentIsHTML && + !nonnativeSelectorCache[ expr + " " ] && + ( !rbuggyMatches || !rbuggyMatches.test( expr ) ) && + ( !rbuggyQSA || !rbuggyQSA.test( expr ) ) ) { + + try { + var ret = matches.call( elem, expr ); + + // IE 9's matchesSelector returns false on disconnected nodes + if ( ret || support.disconnectedMatch || + + // As well, disconnected nodes are said to be in a document + // fragment in IE 9 + elem.document && elem.document.nodeType !== 11 ) { + return ret; + } + } catch ( e ) { + nonnativeSelectorCache( expr, true ); + } + } + + return Sizzle( expr, document, null, [ elem ] ).length > 0; +}; + +Sizzle.contains = function( context, elem ) { + + // Set document vars if needed + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( ( context.ownerDocument || context ) != document ) { + setDocument( context ); + } + return contains( context, elem ); +}; + +Sizzle.attr = function( elem, name ) { + + // Set document vars if needed + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( ( elem.ownerDocument || elem ) != document ) { + setDocument( elem ); + } + + var fn = Expr.attrHandle[ name.toLowerCase() ], + + // Don't get fooled by Object.prototype properties (jQuery #13807) + val = fn && hasOwn.call( Expr.attrHandle, name.toLowerCase() ) ? + fn( elem, name, !documentIsHTML ) : + undefined; + + return val !== undefined ? + val : + support.attributes || !documentIsHTML ? + elem.getAttribute( name ) : + ( val = elem.getAttributeNode( name ) ) && val.specified ? + val.value : + null; +}; + +Sizzle.escape = function( sel ) { + return ( sel + "" ).replace( rcssescape, fcssescape ); +}; + +Sizzle.error = function( msg ) { + throw new Error( "Syntax error, unrecognized expression: " + msg ); +}; + +/** + * Document sorting and removing duplicates + * @param {ArrayLike} results + */ +Sizzle.uniqueSort = function( results ) { + var elem, + duplicates = [], + j = 0, + i = 0; + + // Unless we *know* we can detect duplicates, assume their presence + hasDuplicate = !support.detectDuplicates; + sortInput = !support.sortStable && results.slice( 0 ); + results.sort( sortOrder ); + + if ( hasDuplicate ) { + while ( ( elem = results[ i++ ] ) ) { + if ( elem === results[ i ] ) { + j = duplicates.push( i ); + } + } + while ( j-- ) { + results.splice( duplicates[ j ], 1 ); + } + } + + // Clear input after sorting to release objects + // See https://github.com/jquery/sizzle/pull/225 + sortInput = null; + + return results; +}; + +/** + * Utility function for retrieving the text value of an array of DOM nodes + * @param {Array|Element} elem + */ +getText = Sizzle.getText = function( elem ) { + var node, + ret = "", + i = 0, + nodeType = elem.nodeType; + + if ( !nodeType ) { + + // If no nodeType, this is expected to be an array + while ( ( node = elem[ i++ ] ) ) { + + // Do not traverse comment nodes + ret += getText( node ); + } + } else if ( nodeType === 1 || nodeType === 9 || nodeType === 11 ) { + + // Use textContent for elements + // innerText usage removed for consistency of new lines (jQuery #11153) + if ( typeof elem.textContent === "string" ) { + return elem.textContent; + } else { + + // Traverse its children + for ( elem = elem.firstChild; elem; elem = elem.nextSibling ) { + ret += getText( elem ); + } + } + } else if ( nodeType === 3 || nodeType === 4 ) { + return elem.nodeValue; + } + + // Do not include comment or processing instruction nodes + + return ret; +}; + +Expr = Sizzle.selectors = { + + // Can be adjusted by the user + cacheLength: 50, + + createPseudo: markFunction, + + match: matchExpr, + + attrHandle: {}, + + find: {}, + + relative: { + ">": { dir: "parentNode", first: true }, + " ": { dir: "parentNode" }, + "+": { dir: "previousSibling", first: true }, + "~": { dir: "previousSibling" } + }, + + preFilter: { + "ATTR": function( match ) { + match[ 1 ] = match[ 1 ].replace( runescape, funescape ); + + // Move the given value to match[3] whether quoted or unquoted + match[ 3 ] = ( match[ 3 ] || match[ 4 ] || + match[ 5 ] || "" ).replace( runescape, funescape ); + + if ( match[ 2 ] === "~=" ) { + match[ 3 ] = " " + match[ 3 ] + " "; + } + + return match.slice( 0, 4 ); + }, + + "CHILD": function( match ) { + + /* matches from matchExpr["CHILD"] + 1 type (only|nth|...) + 2 what (child|of-type) + 3 argument (even|odd|\d*|\d*n([+-]\d+)?|...) + 4 xn-component of xn+y argument ([+-]?\d*n|) + 5 sign of xn-component + 6 x of xn-component + 7 sign of y-component + 8 y of y-component + */ + match[ 1 ] = match[ 1 ].toLowerCase(); + + if ( match[ 1 ].slice( 0, 3 ) === "nth" ) { + + // nth-* requires argument + if ( !match[ 3 ] ) { + Sizzle.error( match[ 0 ] ); + } + + // numeric x and y parameters for Expr.filter.CHILD + // remember that false/true cast respectively to 0/1 + match[ 4 ] = +( match[ 4 ] ? + match[ 5 ] + ( match[ 6 ] || 1 ) : + 2 * ( match[ 3 ] === "even" || match[ 3 ] === "odd" ) ); + match[ 5 ] = +( ( match[ 7 ] + match[ 8 ] ) || match[ 3 ] === "odd" ); + + // other types prohibit arguments + } else if ( match[ 3 ] ) { + Sizzle.error( match[ 0 ] ); + } + + return match; + }, + + "PSEUDO": function( match ) { + var excess, + unquoted = !match[ 6 ] && match[ 2 ]; + + if ( matchExpr[ "CHILD" ].test( match[ 0 ] ) ) { + return null; + } + + // Accept quoted arguments as-is + if ( match[ 3 ] ) { + match[ 2 ] = match[ 4 ] || match[ 5 ] || ""; + + // Strip excess characters from unquoted arguments + } else if ( unquoted && rpseudo.test( unquoted ) && + + // Get excess from tokenize (recursively) + ( excess = tokenize( unquoted, true ) ) && + + // advance to the next closing parenthesis + ( excess = unquoted.indexOf( ")", unquoted.length - excess ) - unquoted.length ) ) { + + // excess is a negative index + match[ 0 ] = match[ 0 ].slice( 0, excess ); + match[ 2 ] = unquoted.slice( 0, excess ); + } + + // Return only captures needed by the pseudo filter method (type and argument) + return match.slice( 0, 3 ); + } + }, + + filter: { + + "TAG": function( nodeNameSelector ) { + var nodeName = nodeNameSelector.replace( runescape, funescape ).toLowerCase(); + return nodeNameSelector === "*" ? + function() { + return true; + } : + function( elem ) { + return elem.nodeName && elem.nodeName.toLowerCase() === nodeName; + }; + }, + + "CLASS": function( className ) { + var pattern = classCache[ className + " " ]; + + return pattern || + ( pattern = new RegExp( "(^|" + whitespace + + ")" + className + "(" + whitespace + "|$)" ) ) && classCache( + className, function( elem ) { + return pattern.test( + typeof elem.className === "string" && elem.className || + typeof elem.getAttribute !== "undefined" && + elem.getAttribute( "class" ) || + "" + ); + } ); + }, + + "ATTR": function( name, operator, check ) { + return function( elem ) { + var result = Sizzle.attr( elem, name ); + + if ( result == null ) { + return operator === "!="; + } + if ( !operator ) { + return true; + } + + result += ""; + + /* eslint-disable max-len */ + + return operator === "=" ? result === check : + operator === "!=" ? result !== check : + operator === "^=" ? check && result.indexOf( check ) === 0 : + operator === "*=" ? check && result.indexOf( check ) > -1 : + operator === "$=" ? check && result.slice( -check.length ) === check : + operator === "~=" ? ( " " + result.replace( rwhitespace, " " ) + " " ).indexOf( check ) > -1 : + operator === "|=" ? result === check || result.slice( 0, check.length + 1 ) === check + "-" : + false; + /* eslint-enable max-len */ + + }; + }, + + "CHILD": function( type, what, _argument, first, last ) { + var simple = type.slice( 0, 3 ) !== "nth", + forward = type.slice( -4 ) !== "last", + ofType = what === "of-type"; + + return first === 1 && last === 0 ? + + // Shortcut for :nth-*(n) + function( elem ) { + return !!elem.parentNode; + } : + + function( elem, _context, xml ) { + var cache, uniqueCache, outerCache, node, nodeIndex, start, + dir = simple !== forward ? "nextSibling" : "previousSibling", + parent = elem.parentNode, + name = ofType && elem.nodeName.toLowerCase(), + useCache = !xml && !ofType, + diff = false; + + if ( parent ) { + + // :(first|last|only)-(child|of-type) + if ( simple ) { + while ( dir ) { + node = elem; + while ( ( node = node[ dir ] ) ) { + if ( ofType ? + node.nodeName.toLowerCase() === name : + node.nodeType === 1 ) { + + return false; + } + } + + // Reverse direction for :only-* (if we haven't yet done so) + start = dir = type === "only" && !start && "nextSibling"; + } + return true; + } + + start = [ forward ? parent.firstChild : parent.lastChild ]; + + // non-xml :nth-child(...) stores cache data on `parent` + if ( forward && useCache ) { + + // Seek `elem` from a previously-cached index + + // ...in a gzip-friendly way + node = parent; + outerCache = node[ expando ] || ( node[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ node.uniqueID ] || + ( outerCache[ node.uniqueID ] = {} ); + + cache = uniqueCache[ type ] || []; + nodeIndex = cache[ 0 ] === dirruns && cache[ 1 ]; + diff = nodeIndex && cache[ 2 ]; + node = nodeIndex && parent.childNodes[ nodeIndex ]; + + while ( ( node = ++nodeIndex && node && node[ dir ] || + + // Fallback to seeking `elem` from the start + ( diff = nodeIndex = 0 ) || start.pop() ) ) { + + // When found, cache indexes on `parent` and break + if ( node.nodeType === 1 && ++diff && node === elem ) { + uniqueCache[ type ] = [ dirruns, nodeIndex, diff ]; + break; + } + } + + } else { + + // Use previously-cached element index if available + if ( useCache ) { + + // ...in a gzip-friendly way + node = elem; + outerCache = node[ expando ] || ( node[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ node.uniqueID ] || + ( outerCache[ node.uniqueID ] = {} ); + + cache = uniqueCache[ type ] || []; + nodeIndex = cache[ 0 ] === dirruns && cache[ 1 ]; + diff = nodeIndex; + } + + // xml :nth-child(...) + // or :nth-last-child(...) or :nth(-last)?-of-type(...) + if ( diff === false ) { + + // Use the same loop as above to seek `elem` from the start + while ( ( node = ++nodeIndex && node && node[ dir ] || + ( diff = nodeIndex = 0 ) || start.pop() ) ) { + + if ( ( ofType ? + node.nodeName.toLowerCase() === name : + node.nodeType === 1 ) && + ++diff ) { + + // Cache the index of each encountered element + if ( useCache ) { + outerCache = node[ expando ] || + ( node[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ node.uniqueID ] || + ( outerCache[ node.uniqueID ] = {} ); + + uniqueCache[ type ] = [ dirruns, diff ]; + } + + if ( node === elem ) { + break; + } + } + } + } + } + + // Incorporate the offset, then check against cycle size + diff -= last; + return diff === first || ( diff % first === 0 && diff / first >= 0 ); + } + }; + }, + + "PSEUDO": function( pseudo, argument ) { + + // pseudo-class names are case-insensitive + // http://www.w3.org/TR/selectors/#pseudo-classes + // Prioritize by case sensitivity in case custom pseudos are added with uppercase letters + // Remember that setFilters inherits from pseudos + var args, + fn = Expr.pseudos[ pseudo ] || Expr.setFilters[ pseudo.toLowerCase() ] || + Sizzle.error( "unsupported pseudo: " + pseudo ); + + // The user may use createPseudo to indicate that + // arguments are needed to create the filter function + // just as Sizzle does + if ( fn[ expando ] ) { + return fn( argument ); + } + + // But maintain support for old signatures + if ( fn.length > 1 ) { + args = [ pseudo, pseudo, "", argument ]; + return Expr.setFilters.hasOwnProperty( pseudo.toLowerCase() ) ? + markFunction( function( seed, matches ) { + var idx, + matched = fn( seed, argument ), + i = matched.length; + while ( i-- ) { + idx = indexOf( seed, matched[ i ] ); + seed[ idx ] = !( matches[ idx ] = matched[ i ] ); + } + } ) : + function( elem ) { + return fn( elem, 0, args ); + }; + } + + return fn; + } + }, + + pseudos: { + + // Potentially complex pseudos + "not": markFunction( function( selector ) { + + // Trim the selector passed to compile + // to avoid treating leading and trailing + // spaces as combinators + var input = [], + results = [], + matcher = compile( selector.replace( rtrim, "$1" ) ); + + return matcher[ expando ] ? + markFunction( function( seed, matches, _context, xml ) { + var elem, + unmatched = matcher( seed, null, xml, [] ), + i = seed.length; + + // Match elements unmatched by `matcher` + while ( i-- ) { + if ( ( elem = unmatched[ i ] ) ) { + seed[ i ] = !( matches[ i ] = elem ); + } + } + } ) : + function( elem, _context, xml ) { + input[ 0 ] = elem; + matcher( input, null, xml, results ); + + // Don't keep the element (issue #299) + input[ 0 ] = null; + return !results.pop(); + }; + } ), + + "has": markFunction( function( selector ) { + return function( elem ) { + return Sizzle( selector, elem ).length > 0; + }; + } ), + + "contains": markFunction( function( text ) { + text = text.replace( runescape, funescape ); + return function( elem ) { + return ( elem.textContent || getText( elem ) ).indexOf( text ) > -1; + }; + } ), + + // "Whether an element is represented by a :lang() selector + // is based solely on the element's language value + // being equal to the identifier C, + // or beginning with the identifier C immediately followed by "-". + // The matching of C against the element's language value is performed case-insensitively. + // The identifier C does not have to be a valid language name." + // http://www.w3.org/TR/selectors/#lang-pseudo + "lang": markFunction( function( lang ) { + + // lang value must be a valid identifier + if ( !ridentifier.test( lang || "" ) ) { + Sizzle.error( "unsupported lang: " + lang ); + } + lang = lang.replace( runescape, funescape ).toLowerCase(); + return function( elem ) { + var elemLang; + do { + if ( ( elemLang = documentIsHTML ? + elem.lang : + elem.getAttribute( "xml:lang" ) || elem.getAttribute( "lang" ) ) ) { + + elemLang = elemLang.toLowerCase(); + return elemLang === lang || elemLang.indexOf( lang + "-" ) === 0; + } + } while ( ( elem = elem.parentNode ) && elem.nodeType === 1 ); + return false; + }; + } ), + + // Miscellaneous + "target": function( elem ) { + var hash = window.location && window.location.hash; + return hash && hash.slice( 1 ) === elem.id; + }, + + "root": function( elem ) { + return elem === docElem; + }, + + "focus": function( elem ) { + return elem === document.activeElement && + ( !document.hasFocus || document.hasFocus() ) && + !!( elem.type || elem.href || ~elem.tabIndex ); + }, + + // Boolean properties + "enabled": createDisabledPseudo( false ), + "disabled": createDisabledPseudo( true ), + + "checked": function( elem ) { + + // In CSS3, :checked should return both checked and selected elements + // http://www.w3.org/TR/2011/REC-css3-selectors-20110929/#checked + var nodeName = elem.nodeName.toLowerCase(); + return ( nodeName === "input" && !!elem.checked ) || + ( nodeName === "option" && !!elem.selected ); + }, + + "selected": function( elem ) { + + // Accessing this property makes selected-by-default + // options in Safari work properly + if ( elem.parentNode ) { + // eslint-disable-next-line no-unused-expressions + elem.parentNode.selectedIndex; + } + + return elem.selected === true; + }, + + // Contents + "empty": function( elem ) { + + // http://www.w3.org/TR/selectors/#empty-pseudo + // :empty is negated by element (1) or content nodes (text: 3; cdata: 4; entity ref: 5), + // but not by others (comment: 8; processing instruction: 7; etc.) + // nodeType < 6 works because attributes (2) do not appear as children + for ( elem = elem.firstChild; elem; elem = elem.nextSibling ) { + if ( elem.nodeType < 6 ) { + return false; + } + } + return true; + }, + + "parent": function( elem ) { + return !Expr.pseudos[ "empty" ]( elem ); + }, + + // Element/input types + "header": function( elem ) { + return rheader.test( elem.nodeName ); + }, + + "input": function( elem ) { + return rinputs.test( elem.nodeName ); + }, + + "button": function( elem ) { + var name = elem.nodeName.toLowerCase(); + return name === "input" && elem.type === "button" || name === "button"; + }, + + "text": function( elem ) { + var attr; + return elem.nodeName.toLowerCase() === "input" && + elem.type === "text" && + + // Support: IE<8 + // New HTML5 attribute values (e.g., "search") appear with elem.type === "text" + ( ( attr = elem.getAttribute( "type" ) ) == null || + attr.toLowerCase() === "text" ); + }, + + // Position-in-collection + "first": createPositionalPseudo( function() { + return [ 0 ]; + } ), + + "last": createPositionalPseudo( function( _matchIndexes, length ) { + return [ length - 1 ]; + } ), + + "eq": createPositionalPseudo( function( _matchIndexes, length, argument ) { + return [ argument < 0 ? argument + length : argument ]; + } ), + + "even": createPositionalPseudo( function( matchIndexes, length ) { + var i = 0; + for ( ; i < length; i += 2 ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ), + + "odd": createPositionalPseudo( function( matchIndexes, length ) { + var i = 1; + for ( ; i < length; i += 2 ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ), + + "lt": createPositionalPseudo( function( matchIndexes, length, argument ) { + var i = argument < 0 ? + argument + length : + argument > length ? + length : + argument; + for ( ; --i >= 0; ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ), + + "gt": createPositionalPseudo( function( matchIndexes, length, argument ) { + var i = argument < 0 ? argument + length : argument; + for ( ; ++i < length; ) { + matchIndexes.push( i ); + } + return matchIndexes; + } ) + } +}; + +Expr.pseudos[ "nth" ] = Expr.pseudos[ "eq" ]; + +// Add button/input type pseudos +for ( i in { radio: true, checkbox: true, file: true, password: true, image: true } ) { + Expr.pseudos[ i ] = createInputPseudo( i ); +} +for ( i in { submit: true, reset: true } ) { + Expr.pseudos[ i ] = createButtonPseudo( i ); +} + +// Easy API for creating new setFilters +function setFilters() {} +setFilters.prototype = Expr.filters = Expr.pseudos; +Expr.setFilters = new setFilters(); + +tokenize = Sizzle.tokenize = function( selector, parseOnly ) { + var matched, match, tokens, type, + soFar, groups, preFilters, + cached = tokenCache[ selector + " " ]; + + if ( cached ) { + return parseOnly ? 0 : cached.slice( 0 ); + } + + soFar = selector; + groups = []; + preFilters = Expr.preFilter; + + while ( soFar ) { + + // Comma and first run + if ( !matched || ( match = rcomma.exec( soFar ) ) ) { + if ( match ) { + + // Don't consume trailing commas as valid + soFar = soFar.slice( match[ 0 ].length ) || soFar; + } + groups.push( ( tokens = [] ) ); + } + + matched = false; + + // Combinators + if ( ( match = rcombinators.exec( soFar ) ) ) { + matched = match.shift(); + tokens.push( { + value: matched, + + // Cast descendant combinators to space + type: match[ 0 ].replace( rtrim, " " ) + } ); + soFar = soFar.slice( matched.length ); + } + + // Filters + for ( type in Expr.filter ) { + if ( ( match = matchExpr[ type ].exec( soFar ) ) && ( !preFilters[ type ] || + ( match = preFilters[ type ]( match ) ) ) ) { + matched = match.shift(); + tokens.push( { + value: matched, + type: type, + matches: match + } ); + soFar = soFar.slice( matched.length ); + } + } + + if ( !matched ) { + break; + } + } + + // Return the length of the invalid excess + // if we're just parsing + // Otherwise, throw an error or return tokens + return parseOnly ? + soFar.length : + soFar ? + Sizzle.error( selector ) : + + // Cache the tokens + tokenCache( selector, groups ).slice( 0 ); +}; + +function toSelector( tokens ) { + var i = 0, + len = tokens.length, + selector = ""; + for ( ; i < len; i++ ) { + selector += tokens[ i ].value; + } + return selector; +} + +function addCombinator( matcher, combinator, base ) { + var dir = combinator.dir, + skip = combinator.next, + key = skip || dir, + checkNonElements = base && key === "parentNode", + doneName = done++; + + return combinator.first ? + + // Check against closest ancestor/preceding element + function( elem, context, xml ) { + while ( ( elem = elem[ dir ] ) ) { + if ( elem.nodeType === 1 || checkNonElements ) { + return matcher( elem, context, xml ); + } + } + return false; + } : + + // Check against all ancestor/preceding elements + function( elem, context, xml ) { + var oldCache, uniqueCache, outerCache, + newCache = [ dirruns, doneName ]; + + // We can't set arbitrary data on XML nodes, so they don't benefit from combinator caching + if ( xml ) { + while ( ( elem = elem[ dir ] ) ) { + if ( elem.nodeType === 1 || checkNonElements ) { + if ( matcher( elem, context, xml ) ) { + return true; + } + } + } + } else { + while ( ( elem = elem[ dir ] ) ) { + if ( elem.nodeType === 1 || checkNonElements ) { + outerCache = elem[ expando ] || ( elem[ expando ] = {} ); + + // Support: IE <9 only + // Defend against cloned attroperties (jQuery gh-1709) + uniqueCache = outerCache[ elem.uniqueID ] || + ( outerCache[ elem.uniqueID ] = {} ); + + if ( skip && skip === elem.nodeName.toLowerCase() ) { + elem = elem[ dir ] || elem; + } else if ( ( oldCache = uniqueCache[ key ] ) && + oldCache[ 0 ] === dirruns && oldCache[ 1 ] === doneName ) { + + // Assign to newCache so results back-propagate to previous elements + return ( newCache[ 2 ] = oldCache[ 2 ] ); + } else { + + // Reuse newcache so results back-propagate to previous elements + uniqueCache[ key ] = newCache; + + // A match means we're done; a fail means we have to keep checking + if ( ( newCache[ 2 ] = matcher( elem, context, xml ) ) ) { + return true; + } + } + } + } + } + return false; + }; +} + +function elementMatcher( matchers ) { + return matchers.length > 1 ? + function( elem, context, xml ) { + var i = matchers.length; + while ( i-- ) { + if ( !matchers[ i ]( elem, context, xml ) ) { + return false; + } + } + return true; + } : + matchers[ 0 ]; +} + +function multipleContexts( selector, contexts, results ) { + var i = 0, + len = contexts.length; + for ( ; i < len; i++ ) { + Sizzle( selector, contexts[ i ], results ); + } + return results; +} + +function condense( unmatched, map, filter, context, xml ) { + var elem, + newUnmatched = [], + i = 0, + len = unmatched.length, + mapped = map != null; + + for ( ; i < len; i++ ) { + if ( ( elem = unmatched[ i ] ) ) { + if ( !filter || filter( elem, context, xml ) ) { + newUnmatched.push( elem ); + if ( mapped ) { + map.push( i ); + } + } + } + } + + return newUnmatched; +} + +function setMatcher( preFilter, selector, matcher, postFilter, postFinder, postSelector ) { + if ( postFilter && !postFilter[ expando ] ) { + postFilter = setMatcher( postFilter ); + } + if ( postFinder && !postFinder[ expando ] ) { + postFinder = setMatcher( postFinder, postSelector ); + } + return markFunction( function( seed, results, context, xml ) { + var temp, i, elem, + preMap = [], + postMap = [], + preexisting = results.length, + + // Get initial elements from seed or context + elems = seed || multipleContexts( + selector || "*", + context.nodeType ? [ context ] : context, + [] + ), + + // Prefilter to get matcher input, preserving a map for seed-results synchronization + matcherIn = preFilter && ( seed || !selector ) ? + condense( elems, preMap, preFilter, context, xml ) : + elems, + + matcherOut = matcher ? + + // If we have a postFinder, or filtered seed, or non-seed postFilter or preexisting results, + postFinder || ( seed ? preFilter : preexisting || postFilter ) ? + + // ...intermediate processing is necessary + [] : + + // ...otherwise use results directly + results : + matcherIn; + + // Find primary matches + if ( matcher ) { + matcher( matcherIn, matcherOut, context, xml ); + } + + // Apply postFilter + if ( postFilter ) { + temp = condense( matcherOut, postMap ); + postFilter( temp, [], context, xml ); + + // Un-match failing elements by moving them back to matcherIn + i = temp.length; + while ( i-- ) { + if ( ( elem = temp[ i ] ) ) { + matcherOut[ postMap[ i ] ] = !( matcherIn[ postMap[ i ] ] = elem ); + } + } + } + + if ( seed ) { + if ( postFinder || preFilter ) { + if ( postFinder ) { + + // Get the final matcherOut by condensing this intermediate into postFinder contexts + temp = []; + i = matcherOut.length; + while ( i-- ) { + if ( ( elem = matcherOut[ i ] ) ) { + + // Restore matcherIn since elem is not yet a final match + temp.push( ( matcherIn[ i ] = elem ) ); + } + } + postFinder( null, ( matcherOut = [] ), temp, xml ); + } + + // Move matched elements from seed to results to keep them synchronized + i = matcherOut.length; + while ( i-- ) { + if ( ( elem = matcherOut[ i ] ) && + ( temp = postFinder ? indexOf( seed, elem ) : preMap[ i ] ) > -1 ) { + + seed[ temp ] = !( results[ temp ] = elem ); + } + } + } + + // Add elements to results, through postFinder if defined + } else { + matcherOut = condense( + matcherOut === results ? + matcherOut.splice( preexisting, matcherOut.length ) : + matcherOut + ); + if ( postFinder ) { + postFinder( null, results, matcherOut, xml ); + } else { + push.apply( results, matcherOut ); + } + } + } ); +} + +function matcherFromTokens( tokens ) { + var checkContext, matcher, j, + len = tokens.length, + leadingRelative = Expr.relative[ tokens[ 0 ].type ], + implicitRelative = leadingRelative || Expr.relative[ " " ], + i = leadingRelative ? 1 : 0, + + // The foundational matcher ensures that elements are reachable from top-level context(s) + matchContext = addCombinator( function( elem ) { + return elem === checkContext; + }, implicitRelative, true ), + matchAnyContext = addCombinator( function( elem ) { + return indexOf( checkContext, elem ) > -1; + }, implicitRelative, true ), + matchers = [ function( elem, context, xml ) { + var ret = ( !leadingRelative && ( xml || context !== outermostContext ) ) || ( + ( checkContext = context ).nodeType ? + matchContext( elem, context, xml ) : + matchAnyContext( elem, context, xml ) ); + + // Avoid hanging onto element (issue #299) + checkContext = null; + return ret; + } ]; + + for ( ; i < len; i++ ) { + if ( ( matcher = Expr.relative[ tokens[ i ].type ] ) ) { + matchers = [ addCombinator( elementMatcher( matchers ), matcher ) ]; + } else { + matcher = Expr.filter[ tokens[ i ].type ].apply( null, tokens[ i ].matches ); + + // Return special upon seeing a positional matcher + if ( matcher[ expando ] ) { + + // Find the next relative operator (if any) for proper handling + j = ++i; + for ( ; j < len; j++ ) { + if ( Expr.relative[ tokens[ j ].type ] ) { + break; + } + } + return setMatcher( + i > 1 && elementMatcher( matchers ), + i > 1 && toSelector( + + // If the preceding token was a descendant combinator, insert an implicit any-element `*` + tokens + .slice( 0, i - 1 ) + .concat( { value: tokens[ i - 2 ].type === " " ? "*" : "" } ) + ).replace( rtrim, "$1" ), + matcher, + i < j && matcherFromTokens( tokens.slice( i, j ) ), + j < len && matcherFromTokens( ( tokens = tokens.slice( j ) ) ), + j < len && toSelector( tokens ) + ); + } + matchers.push( matcher ); + } + } + + return elementMatcher( matchers ); +} + +function matcherFromGroupMatchers( elementMatchers, setMatchers ) { + var bySet = setMatchers.length > 0, + byElement = elementMatchers.length > 0, + superMatcher = function( seed, context, xml, results, outermost ) { + var elem, j, matcher, + matchedCount = 0, + i = "0", + unmatched = seed && [], + setMatched = [], + contextBackup = outermostContext, + + // We must always have either seed elements or outermost context + elems = seed || byElement && Expr.find[ "TAG" ]( "*", outermost ), + + // Use integer dirruns iff this is the outermost matcher + dirrunsUnique = ( dirruns += contextBackup == null ? 1 : Math.random() || 0.1 ), + len = elems.length; + + if ( outermost ) { + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + outermostContext = context == document || context || outermost; + } + + // Add elements passing elementMatchers directly to results + // Support: IE<9, Safari + // Tolerate NodeList properties (IE: "length"; Safari: ) matching elements by id + for ( ; i !== len && ( elem = elems[ i ] ) != null; i++ ) { + if ( byElement && elem ) { + j = 0; + + // Support: IE 11+, Edge 17 - 18+ + // IE/Edge sometimes throw a "Permission denied" error when strict-comparing + // two documents; shallow comparisons work. + // eslint-disable-next-line eqeqeq + if ( !context && elem.ownerDocument != document ) { + setDocument( elem ); + xml = !documentIsHTML; + } + while ( ( matcher = elementMatchers[ j++ ] ) ) { + if ( matcher( elem, context || document, xml ) ) { + results.push( elem ); + break; + } + } + if ( outermost ) { + dirruns = dirrunsUnique; + } + } + + // Track unmatched elements for set filters + if ( bySet ) { + + // They will have gone through all possible matchers + if ( ( elem = !matcher && elem ) ) { + matchedCount--; + } + + // Lengthen the array for every element, matched or not + if ( seed ) { + unmatched.push( elem ); + } + } + } + + // `i` is now the count of elements visited above, and adding it to `matchedCount` + // makes the latter nonnegative. + matchedCount += i; + + // Apply set filters to unmatched elements + // NOTE: This can be skipped if there are no unmatched elements (i.e., `matchedCount` + // equals `i`), unless we didn't visit _any_ elements in the above loop because we have + // no element matchers and no seed. + // Incrementing an initially-string "0" `i` allows `i` to remain a string only in that + // case, which will result in a "00" `matchedCount` that differs from `i` but is also + // numerically zero. + if ( bySet && i !== matchedCount ) { + j = 0; + while ( ( matcher = setMatchers[ j++ ] ) ) { + matcher( unmatched, setMatched, context, xml ); + } + + if ( seed ) { + + // Reintegrate element matches to eliminate the need for sorting + if ( matchedCount > 0 ) { + while ( i-- ) { + if ( !( unmatched[ i ] || setMatched[ i ] ) ) { + setMatched[ i ] = pop.call( results ); + } + } + } + + // Discard index placeholder values to get only actual matches + setMatched = condense( setMatched ); + } + + // Add matches to results + push.apply( results, setMatched ); + + // Seedless set matches succeeding multiple successful matchers stipulate sorting + if ( outermost && !seed && setMatched.length > 0 && + ( matchedCount + setMatchers.length ) > 1 ) { + + Sizzle.uniqueSort( results ); + } + } + + // Override manipulation of globals by nested matchers + if ( outermost ) { + dirruns = dirrunsUnique; + outermostContext = contextBackup; + } + + return unmatched; + }; + + return bySet ? + markFunction( superMatcher ) : + superMatcher; +} + +compile = Sizzle.compile = function( selector, match /* Internal Use Only */ ) { + var i, + setMatchers = [], + elementMatchers = [], + cached = compilerCache[ selector + " " ]; + + if ( !cached ) { + + // Generate a function of recursive functions that can be used to check each element + if ( !match ) { + match = tokenize( selector ); + } + i = match.length; + while ( i-- ) { + cached = matcherFromTokens( match[ i ] ); + if ( cached[ expando ] ) { + setMatchers.push( cached ); + } else { + elementMatchers.push( cached ); + } + } + + // Cache the compiled function + cached = compilerCache( + selector, + matcherFromGroupMatchers( elementMatchers, setMatchers ) + ); + + // Save selector and tokenization + cached.selector = selector; + } + return cached; +}; + +/** + * A low-level selection function that works with Sizzle's compiled + * selector functions + * @param {String|Function} selector A selector or a pre-compiled + * selector function built with Sizzle.compile + * @param {Element} context + * @param {Array} [results] + * @param {Array} [seed] A set of elements to match against + */ +select = Sizzle.select = function( selector, context, results, seed ) { + var i, tokens, token, type, find, + compiled = typeof selector === "function" && selector, + match = !seed && tokenize( ( selector = compiled.selector || selector ) ); + + results = results || []; + + // Try to minimize operations if there is only one selector in the list and no seed + // (the latter of which guarantees us context) + if ( match.length === 1 ) { + + // Reduce context if the leading compound selector is an ID + tokens = match[ 0 ] = match[ 0 ].slice( 0 ); + if ( tokens.length > 2 && ( token = tokens[ 0 ] ).type === "ID" && + context.nodeType === 9 && documentIsHTML && Expr.relative[ tokens[ 1 ].type ] ) { + + context = ( Expr.find[ "ID" ]( token.matches[ 0 ] + .replace( runescape, funescape ), context ) || [] )[ 0 ]; + if ( !context ) { + return results; + + // Precompiled matchers will still verify ancestry, so step up a level + } else if ( compiled ) { + context = context.parentNode; + } + + selector = selector.slice( tokens.shift().value.length ); + } + + // Fetch a seed set for right-to-left matching + i = matchExpr[ "needsContext" ].test( selector ) ? 0 : tokens.length; + while ( i-- ) { + token = tokens[ i ]; + + // Abort if we hit a combinator + if ( Expr.relative[ ( type = token.type ) ] ) { + break; + } + if ( ( find = Expr.find[ type ] ) ) { + + // Search, expanding context for leading sibling combinators + if ( ( seed = find( + token.matches[ 0 ].replace( runescape, funescape ), + rsibling.test( tokens[ 0 ].type ) && testContext( context.parentNode ) || + context + ) ) ) { + + // If seed is empty or no tokens remain, we can return early + tokens.splice( i, 1 ); + selector = seed.length && toSelector( tokens ); + if ( !selector ) { + push.apply( results, seed ); + return results; + } + + break; + } + } + } + } + + // Compile and execute a filtering function if one is not provided + // Provide `match` to avoid retokenization if we modified the selector above + ( compiled || compile( selector, match ) )( + seed, + context, + !documentIsHTML, + results, + !context || rsibling.test( selector ) && testContext( context.parentNode ) || context + ); + return results; +}; + +// One-time assignments + +// Sort stability +support.sortStable = expando.split( "" ).sort( sortOrder ).join( "" ) === expando; + +// Support: Chrome 14-35+ +// Always assume duplicates if they aren't passed to the comparison function +support.detectDuplicates = !!hasDuplicate; + +// Initialize against the default document +setDocument(); + +// Support: Webkit<537.32 - Safari 6.0.3/Chrome 25 (fixed in Chrome 27) +// Detached nodes confoundingly follow *each other* +support.sortDetached = assert( function( el ) { + + // Should return 1, but returns 4 (following) + return el.compareDocumentPosition( document.createElement( "fieldset" ) ) & 1; +} ); + +// Support: IE<8 +// Prevent attribute/property "interpolation" +// https://msdn.microsoft.com/en-us/library/ms536429%28VS.85%29.aspx +if ( !assert( function( el ) { + el.innerHTML = ""; + return el.firstChild.getAttribute( "href" ) === "#"; +} ) ) { + addHandle( "type|href|height|width", function( elem, name, isXML ) { + if ( !isXML ) { + return elem.getAttribute( name, name.toLowerCase() === "type" ? 1 : 2 ); + } + } ); +} + +// Support: IE<9 +// Use defaultValue in place of getAttribute("value") +if ( !support.attributes || !assert( function( el ) { + el.innerHTML = ""; + el.firstChild.setAttribute( "value", "" ); + return el.firstChild.getAttribute( "value" ) === ""; +} ) ) { + addHandle( "value", function( elem, _name, isXML ) { + if ( !isXML && elem.nodeName.toLowerCase() === "input" ) { + return elem.defaultValue; + } + } ); +} + +// Support: IE<9 +// Use getAttributeNode to fetch booleans when getAttribute lies +if ( !assert( function( el ) { + return el.getAttribute( "disabled" ) == null; +} ) ) { + addHandle( booleans, function( elem, name, isXML ) { + var val; + if ( !isXML ) { + return elem[ name ] === true ? name.toLowerCase() : + ( val = elem.getAttributeNode( name ) ) && val.specified ? + val.value : + null; + } + } ); +} + +return Sizzle; + +} )( window ); + + + +jQuery.find = Sizzle; +jQuery.expr = Sizzle.selectors; + +// Deprecated +jQuery.expr[ ":" ] = jQuery.expr.pseudos; +jQuery.uniqueSort = jQuery.unique = Sizzle.uniqueSort; +jQuery.text = Sizzle.getText; +jQuery.isXMLDoc = Sizzle.isXML; +jQuery.contains = Sizzle.contains; +jQuery.escapeSelector = Sizzle.escape; + + + + +var dir = function( elem, dir, until ) { + var matched = [], + truncate = until !== undefined; + + while ( ( elem = elem[ dir ] ) && elem.nodeType !== 9 ) { + if ( elem.nodeType === 1 ) { + if ( truncate && jQuery( elem ).is( until ) ) { + break; + } + matched.push( elem ); + } + } + return matched; +}; + + +var siblings = function( n, elem ) { + var matched = []; + + for ( ; n; n = n.nextSibling ) { + if ( n.nodeType === 1 && n !== elem ) { + matched.push( n ); + } + } + + return matched; +}; + + +var rneedsContext = jQuery.expr.match.needsContext; + + + +function nodeName( elem, name ) { + + return elem.nodeName && elem.nodeName.toLowerCase() === name.toLowerCase(); + +} +var rsingleTag = ( /^<([a-z][^\/\0>:\x20\t\r\n\f]*)[\x20\t\r\n\f]*\/?>(?:<\/\1>|)$/i ); + + + +// Implement the identical functionality for filter and not +function winnow( elements, qualifier, not ) { + if ( isFunction( qualifier ) ) { + return jQuery.grep( elements, function( elem, i ) { + return !!qualifier.call( elem, i, elem ) !== not; + } ); + } + + // Single element + if ( qualifier.nodeType ) { + return jQuery.grep( elements, function( elem ) { + return ( elem === qualifier ) !== not; + } ); + } + + // Arraylike of elements (jQuery, arguments, Array) + if ( typeof qualifier !== "string" ) { + return jQuery.grep( elements, function( elem ) { + return ( indexOf.call( qualifier, elem ) > -1 ) !== not; + } ); + } + + // Filtered directly for both simple and complex selectors + return jQuery.filter( qualifier, elements, not ); +} + +jQuery.filter = function( expr, elems, not ) { + var elem = elems[ 0 ]; + + if ( not ) { + expr = ":not(" + expr + ")"; + } + + if ( elems.length === 1 && elem.nodeType === 1 ) { + return jQuery.find.matchesSelector( elem, expr ) ? [ elem ] : []; + } + + return jQuery.find.matches( expr, jQuery.grep( elems, function( elem ) { + return elem.nodeType === 1; + } ) ); +}; + +jQuery.fn.extend( { + find: function( selector ) { + var i, ret, + len = this.length, + self = this; + + if ( typeof selector !== "string" ) { + return this.pushStack( jQuery( selector ).filter( function() { + for ( i = 0; i < len; i++ ) { + if ( jQuery.contains( self[ i ], this ) ) { + return true; + } + } + } ) ); + } + + ret = this.pushStack( [] ); + + for ( i = 0; i < len; i++ ) { + jQuery.find( selector, self[ i ], ret ); + } + + return len > 1 ? jQuery.uniqueSort( ret ) : ret; + }, + filter: function( selector ) { + return this.pushStack( winnow( this, selector || [], false ) ); + }, + not: function( selector ) { + return this.pushStack( winnow( this, selector || [], true ) ); + }, + is: function( selector ) { + return !!winnow( + this, + + // If this is a positional/relative selector, check membership in the returned set + // so $("p:first").is("p:last") won't return true for a doc with two "p". + typeof selector === "string" && rneedsContext.test( selector ) ? + jQuery( selector ) : + selector || [], + false + ).length; + } +} ); + + +// Initialize a jQuery object + + +// A central reference to the root jQuery(document) +var rootjQuery, + + // A simple way to check for HTML strings + // Prioritize #id over to avoid XSS via location.hash (#9521) + // Strict HTML recognition (#11290: must start with <) + // Shortcut simple #id case for speed + rquickExpr = /^(?:\s*(<[\w\W]+>)[^>]*|#([\w-]+))$/, + + init = jQuery.fn.init = function( selector, context, root ) { + var match, elem; + + // HANDLE: $(""), $(null), $(undefined), $(false) + if ( !selector ) { + return this; + } + + // Method init() accepts an alternate rootjQuery + // so migrate can support jQuery.sub (gh-2101) + root = root || rootjQuery; + + // Handle HTML strings + if ( typeof selector === "string" ) { + if ( selector[ 0 ] === "<" && + selector[ selector.length - 1 ] === ">" && + selector.length >= 3 ) { + + // Assume that strings that start and end with <> are HTML and skip the regex check + match = [ null, selector, null ]; + + } else { + match = rquickExpr.exec( selector ); + } + + // Match html or make sure no context is specified for #id + if ( match && ( match[ 1 ] || !context ) ) { + + // HANDLE: $(html) -> $(array) + if ( match[ 1 ] ) { + context = context instanceof jQuery ? context[ 0 ] : context; + + // Option to run scripts is true for back-compat + // Intentionally let the error be thrown if parseHTML is not present + jQuery.merge( this, jQuery.parseHTML( + match[ 1 ], + context && context.nodeType ? context.ownerDocument || context : document, + true + ) ); + + // HANDLE: $(html, props) + if ( rsingleTag.test( match[ 1 ] ) && jQuery.isPlainObject( context ) ) { + for ( match in context ) { + + // Properties of context are called as methods if possible + if ( isFunction( this[ match ] ) ) { + this[ match ]( context[ match ] ); + + // ...and otherwise set as attributes + } else { + this.attr( match, context[ match ] ); + } + } + } + + return this; + + // HANDLE: $(#id) + } else { + elem = document.getElementById( match[ 2 ] ); + + if ( elem ) { + + // Inject the element directly into the jQuery object + this[ 0 ] = elem; + this.length = 1; + } + return this; + } + + // HANDLE: $(expr, $(...)) + } else if ( !context || context.jquery ) { + return ( context || root ).find( selector ); + + // HANDLE: $(expr, context) + // (which is just equivalent to: $(context).find(expr) + } else { + return this.constructor( context ).find( selector ); + } + + // HANDLE: $(DOMElement) + } else if ( selector.nodeType ) { + this[ 0 ] = selector; + this.length = 1; + return this; + + // HANDLE: $(function) + // Shortcut for document ready + } else if ( isFunction( selector ) ) { + return root.ready !== undefined ? + root.ready( selector ) : + + // Execute immediately if ready is not present + selector( jQuery ); + } + + return jQuery.makeArray( selector, this ); + }; + +// Give the init function the jQuery prototype for later instantiation +init.prototype = jQuery.fn; + +// Initialize central reference +rootjQuery = jQuery( document ); + + +var rparentsprev = /^(?:parents|prev(?:Until|All))/, + + // Methods guaranteed to produce a unique set when starting from a unique set + guaranteedUnique = { + children: true, + contents: true, + next: true, + prev: true + }; + +jQuery.fn.extend( { + has: function( target ) { + var targets = jQuery( target, this ), + l = targets.length; + + return this.filter( function() { + var i = 0; + for ( ; i < l; i++ ) { + if ( jQuery.contains( this, targets[ i ] ) ) { + return true; + } + } + } ); + }, + + closest: function( selectors, context ) { + var cur, + i = 0, + l = this.length, + matched = [], + targets = typeof selectors !== "string" && jQuery( selectors ); + + // Positional selectors never match, since there's no _selection_ context + if ( !rneedsContext.test( selectors ) ) { + for ( ; i < l; i++ ) { + for ( cur = this[ i ]; cur && cur !== context; cur = cur.parentNode ) { + + // Always skip document fragments + if ( cur.nodeType < 11 && ( targets ? + targets.index( cur ) > -1 : + + // Don't pass non-elements to Sizzle + cur.nodeType === 1 && + jQuery.find.matchesSelector( cur, selectors ) ) ) { + + matched.push( cur ); + break; + } + } + } + } + + return this.pushStack( matched.length > 1 ? jQuery.uniqueSort( matched ) : matched ); + }, + + // Determine the position of an element within the set + index: function( elem ) { + + // No argument, return index in parent + if ( !elem ) { + return ( this[ 0 ] && this[ 0 ].parentNode ) ? this.first().prevAll().length : -1; + } + + // Index in selector + if ( typeof elem === "string" ) { + return indexOf.call( jQuery( elem ), this[ 0 ] ); + } + + // Locate the position of the desired element + return indexOf.call( this, + + // If it receives a jQuery object, the first element is used + elem.jquery ? elem[ 0 ] : elem + ); + }, + + add: function( selector, context ) { + return this.pushStack( + jQuery.uniqueSort( + jQuery.merge( this.get(), jQuery( selector, context ) ) + ) + ); + }, + + addBack: function( selector ) { + return this.add( selector == null ? + this.prevObject : this.prevObject.filter( selector ) + ); + } +} ); + +function sibling( cur, dir ) { + while ( ( cur = cur[ dir ] ) && cur.nodeType !== 1 ) {} + return cur; +} + +jQuery.each( { + parent: function( elem ) { + var parent = elem.parentNode; + return parent && parent.nodeType !== 11 ? parent : null; + }, + parents: function( elem ) { + return dir( elem, "parentNode" ); + }, + parentsUntil: function( elem, _i, until ) { + return dir( elem, "parentNode", until ); + }, + next: function( elem ) { + return sibling( elem, "nextSibling" ); + }, + prev: function( elem ) { + return sibling( elem, "previousSibling" ); + }, + nextAll: function( elem ) { + return dir( elem, "nextSibling" ); + }, + prevAll: function( elem ) { + return dir( elem, "previousSibling" ); + }, + nextUntil: function( elem, _i, until ) { + return dir( elem, "nextSibling", until ); + }, + prevUntil: function( elem, _i, until ) { + return dir( elem, "previousSibling", until ); + }, + siblings: function( elem ) { + return siblings( ( elem.parentNode || {} ).firstChild, elem ); + }, + children: function( elem ) { + return siblings( elem.firstChild ); + }, + contents: function( elem ) { + if ( elem.contentDocument != null && + + // Support: IE 11+ + // elements with no `data` attribute has an object + // `contentDocument` with a `null` prototype. + getProto( elem.contentDocument ) ) { + + return elem.contentDocument; + } + + // Support: IE 9 - 11 only, iOS 7 only, Android Browser <=4.3 only + // Treat the template element as a regular one in browsers that + // don't support it. + if ( nodeName( elem, "template" ) ) { + elem = elem.content || elem; + } + + return jQuery.merge( [], elem.childNodes ); + } +}, function( name, fn ) { + jQuery.fn[ name ] = function( until, selector ) { + var matched = jQuery.map( this, fn, until ); + + if ( name.slice( -5 ) !== "Until" ) { + selector = until; + } + + if ( selector && typeof selector === "string" ) { + matched = jQuery.filter( selector, matched ); + } + + if ( this.length > 1 ) { + + // Remove duplicates + if ( !guaranteedUnique[ name ] ) { + jQuery.uniqueSort( matched ); + } + + // Reverse order for parents* and prev-derivatives + if ( rparentsprev.test( name ) ) { + matched.reverse(); + } + } + + return this.pushStack( matched ); + }; +} ); +var rnothtmlwhite = ( /[^\x20\t\r\n\f]+/g ); + + + +// Convert String-formatted options into Object-formatted ones +function createOptions( options ) { + var object = {}; + jQuery.each( options.match( rnothtmlwhite ) || [], function( _, flag ) { + object[ flag ] = true; + } ); + return object; +} + +/* + * Create a callback list using the following parameters: + * + * options: an optional list of space-separated options that will change how + * the callback list behaves or a more traditional option object + * + * By default a callback list will act like an event callback list and can be + * "fired" multiple times. + * + * Possible options: + * + * once: will ensure the callback list can only be fired once (like a Deferred) + * + * memory: will keep track of previous values and will call any callback added + * after the list has been fired right away with the latest "memorized" + * values (like a Deferred) + * + * unique: will ensure a callback can only be added once (no duplicate in the list) + * + * stopOnFalse: interrupt callings when a callback returns false + * + */ +jQuery.Callbacks = function( options ) { + + // Convert options from String-formatted to Object-formatted if needed + // (we check in cache first) + options = typeof options === "string" ? + createOptions( options ) : + jQuery.extend( {}, options ); + + var // Flag to know if list is currently firing + firing, + + // Last fire value for non-forgettable lists + memory, + + // Flag to know if list was already fired + fired, + + // Flag to prevent firing + locked, + + // Actual callback list + list = [], + + // Queue of execution data for repeatable lists + queue = [], + + // Index of currently firing callback (modified by add/remove as needed) + firingIndex = -1, + + // Fire callbacks + fire = function() { + + // Enforce single-firing + locked = locked || options.once; + + // Execute callbacks for all pending executions, + // respecting firingIndex overrides and runtime changes + fired = firing = true; + for ( ; queue.length; firingIndex = -1 ) { + memory = queue.shift(); + while ( ++firingIndex < list.length ) { + + // Run callback and check for early termination + if ( list[ firingIndex ].apply( memory[ 0 ], memory[ 1 ] ) === false && + options.stopOnFalse ) { + + // Jump to end and forget the data so .add doesn't re-fire + firingIndex = list.length; + memory = false; + } + } + } + + // Forget the data if we're done with it + if ( !options.memory ) { + memory = false; + } + + firing = false; + + // Clean up if we're done firing for good + if ( locked ) { + + // Keep an empty list if we have data for future add calls + if ( memory ) { + list = []; + + // Otherwise, this object is spent + } else { + list = ""; + } + } + }, + + // Actual Callbacks object + self = { + + // Add a callback or a collection of callbacks to the list + add: function() { + if ( list ) { + + // If we have memory from a past run, we should fire after adding + if ( memory && !firing ) { + firingIndex = list.length - 1; + queue.push( memory ); + } + + ( function add( args ) { + jQuery.each( args, function( _, arg ) { + if ( isFunction( arg ) ) { + if ( !options.unique || !self.has( arg ) ) { + list.push( arg ); + } + } else if ( arg && arg.length && toType( arg ) !== "string" ) { + + // Inspect recursively + add( arg ); + } + } ); + } )( arguments ); + + if ( memory && !firing ) { + fire(); + } + } + return this; + }, + + // Remove a callback from the list + remove: function() { + jQuery.each( arguments, function( _, arg ) { + var index; + while ( ( index = jQuery.inArray( arg, list, index ) ) > -1 ) { + list.splice( index, 1 ); + + // Handle firing indexes + if ( index <= firingIndex ) { + firingIndex--; + } + } + } ); + return this; + }, + + // Check if a given callback is in the list. + // If no argument is given, return whether or not list has callbacks attached. + has: function( fn ) { + return fn ? + jQuery.inArray( fn, list ) > -1 : + list.length > 0; + }, + + // Remove all callbacks from the list + empty: function() { + if ( list ) { + list = []; + } + return this; + }, + + // Disable .fire and .add + // Abort any current/pending executions + // Clear all callbacks and values + disable: function() { + locked = queue = []; + list = memory = ""; + return this; + }, + disabled: function() { + return !list; + }, + + // Disable .fire + // Also disable .add unless we have memory (since it would have no effect) + // Abort any pending executions + lock: function() { + locked = queue = []; + if ( !memory && !firing ) { + list = memory = ""; + } + return this; + }, + locked: function() { + return !!locked; + }, + + // Call all callbacks with the given context and arguments + fireWith: function( context, args ) { + if ( !locked ) { + args = args || []; + args = [ context, args.slice ? args.slice() : args ]; + queue.push( args ); + if ( !firing ) { + fire(); + } + } + return this; + }, + + // Call all the callbacks with the given arguments + fire: function() { + self.fireWith( this, arguments ); + return this; + }, + + // To know if the callbacks have already been called at least once + fired: function() { + return !!fired; + } + }; + + return self; +}; + + +function Identity( v ) { + return v; +} +function Thrower( ex ) { + throw ex; +} + +function adoptValue( value, resolve, reject, noValue ) { + var method; + + try { + + // Check for promise aspect first to privilege synchronous behavior + if ( value && isFunction( ( method = value.promise ) ) ) { + method.call( value ).done( resolve ).fail( reject ); + + // Other thenables + } else if ( value && isFunction( ( method = value.then ) ) ) { + method.call( value, resolve, reject ); + + // Other non-thenables + } else { + + // Control `resolve` arguments by letting Array#slice cast boolean `noValue` to integer: + // * false: [ value ].slice( 0 ) => resolve( value ) + // * true: [ value ].slice( 1 ) => resolve() + resolve.apply( undefined, [ value ].slice( noValue ) ); + } + + // For Promises/A+, convert exceptions into rejections + // Since jQuery.when doesn't unwrap thenables, we can skip the extra checks appearing in + // Deferred#then to conditionally suppress rejection. + } catch ( value ) { + + // Support: Android 4.0 only + // Strict mode functions invoked without .call/.apply get global-object context + reject.apply( undefined, [ value ] ); + } +} + +jQuery.extend( { + + Deferred: function( func ) { + var tuples = [ + + // action, add listener, callbacks, + // ... .then handlers, argument index, [final state] + [ "notify", "progress", jQuery.Callbacks( "memory" ), + jQuery.Callbacks( "memory" ), 2 ], + [ "resolve", "done", jQuery.Callbacks( "once memory" ), + jQuery.Callbacks( "once memory" ), 0, "resolved" ], + [ "reject", "fail", jQuery.Callbacks( "once memory" ), + jQuery.Callbacks( "once memory" ), 1, "rejected" ] + ], + state = "pending", + promise = { + state: function() { + return state; + }, + always: function() { + deferred.done( arguments ).fail( arguments ); + return this; + }, + "catch": function( fn ) { + return promise.then( null, fn ); + }, + + // Keep pipe for back-compat + pipe: function( /* fnDone, fnFail, fnProgress */ ) { + var fns = arguments; + + return jQuery.Deferred( function( newDefer ) { + jQuery.each( tuples, function( _i, tuple ) { + + // Map tuples (progress, done, fail) to arguments (done, fail, progress) + var fn = isFunction( fns[ tuple[ 4 ] ] ) && fns[ tuple[ 4 ] ]; + + // deferred.progress(function() { bind to newDefer or newDefer.notify }) + // deferred.done(function() { bind to newDefer or newDefer.resolve }) + // deferred.fail(function() { bind to newDefer or newDefer.reject }) + deferred[ tuple[ 1 ] ]( function() { + var returned = fn && fn.apply( this, arguments ); + if ( returned && isFunction( returned.promise ) ) { + returned.promise() + .progress( newDefer.notify ) + .done( newDefer.resolve ) + .fail( newDefer.reject ); + } else { + newDefer[ tuple[ 0 ] + "With" ]( + this, + fn ? [ returned ] : arguments + ); + } + } ); + } ); + fns = null; + } ).promise(); + }, + then: function( onFulfilled, onRejected, onProgress ) { + var maxDepth = 0; + function resolve( depth, deferred, handler, special ) { + return function() { + var that = this, + args = arguments, + mightThrow = function() { + var returned, then; + + // Support: Promises/A+ section 2.3.3.3.3 + // https://promisesaplus.com/#point-59 + // Ignore double-resolution attempts + if ( depth < maxDepth ) { + return; + } + + returned = handler.apply( that, args ); + + // Support: Promises/A+ section 2.3.1 + // https://promisesaplus.com/#point-48 + if ( returned === deferred.promise() ) { + throw new TypeError( "Thenable self-resolution" ); + } + + // Support: Promises/A+ sections 2.3.3.1, 3.5 + // https://promisesaplus.com/#point-54 + // https://promisesaplus.com/#point-75 + // Retrieve `then` only once + then = returned && + + // Support: Promises/A+ section 2.3.4 + // https://promisesaplus.com/#point-64 + // Only check objects and functions for thenability + ( typeof returned === "object" || + typeof returned === "function" ) && + returned.then; + + // Handle a returned thenable + if ( isFunction( then ) ) { + + // Special processors (notify) just wait for resolution + if ( special ) { + then.call( + returned, + resolve( maxDepth, deferred, Identity, special ), + resolve( maxDepth, deferred, Thrower, special ) + ); + + // Normal processors (resolve) also hook into progress + } else { + + // ...and disregard older resolution values + maxDepth++; + + then.call( + returned, + resolve( maxDepth, deferred, Identity, special ), + resolve( maxDepth, deferred, Thrower, special ), + resolve( maxDepth, deferred, Identity, + deferred.notifyWith ) + ); + } + + // Handle all other returned values + } else { + + // Only substitute handlers pass on context + // and multiple values (non-spec behavior) + if ( handler !== Identity ) { + that = undefined; + args = [ returned ]; + } + + // Process the value(s) + // Default process is resolve + ( special || deferred.resolveWith )( that, args ); + } + }, + + // Only normal processors (resolve) catch and reject exceptions + process = special ? + mightThrow : + function() { + try { + mightThrow(); + } catch ( e ) { + + if ( jQuery.Deferred.exceptionHook ) { + jQuery.Deferred.exceptionHook( e, + process.stackTrace ); + } + + // Support: Promises/A+ section 2.3.3.3.4.1 + // https://promisesaplus.com/#point-61 + // Ignore post-resolution exceptions + if ( depth + 1 >= maxDepth ) { + + // Only substitute handlers pass on context + // and multiple values (non-spec behavior) + if ( handler !== Thrower ) { + that = undefined; + args = [ e ]; + } + + deferred.rejectWith( that, args ); + } + } + }; + + // Support: Promises/A+ section 2.3.3.3.1 + // https://promisesaplus.com/#point-57 + // Re-resolve promises immediately to dodge false rejection from + // subsequent errors + if ( depth ) { + process(); + } else { + + // Call an optional hook to record the stack, in case of exception + // since it's otherwise lost when execution goes async + if ( jQuery.Deferred.getStackHook ) { + process.stackTrace = jQuery.Deferred.getStackHook(); + } + window.setTimeout( process ); + } + }; + } + + return jQuery.Deferred( function( newDefer ) { + + // progress_handlers.add( ... ) + tuples[ 0 ][ 3 ].add( + resolve( + 0, + newDefer, + isFunction( onProgress ) ? + onProgress : + Identity, + newDefer.notifyWith + ) + ); + + // fulfilled_handlers.add( ... ) + tuples[ 1 ][ 3 ].add( + resolve( + 0, + newDefer, + isFunction( onFulfilled ) ? + onFulfilled : + Identity + ) + ); + + // rejected_handlers.add( ... ) + tuples[ 2 ][ 3 ].add( + resolve( + 0, + newDefer, + isFunction( onRejected ) ? + onRejected : + Thrower + ) + ); + } ).promise(); + }, + + // Get a promise for this deferred + // If obj is provided, the promise aspect is added to the object + promise: function( obj ) { + return obj != null ? jQuery.extend( obj, promise ) : promise; + } + }, + deferred = {}; + + // Add list-specific methods + jQuery.each( tuples, function( i, tuple ) { + var list = tuple[ 2 ], + stateString = tuple[ 5 ]; + + // promise.progress = list.add + // promise.done = list.add + // promise.fail = list.add + promise[ tuple[ 1 ] ] = list.add; + + // Handle state + if ( stateString ) { + list.add( + function() { + + // state = "resolved" (i.e., fulfilled) + // state = "rejected" + state = stateString; + }, + + // rejected_callbacks.disable + // fulfilled_callbacks.disable + tuples[ 3 - i ][ 2 ].disable, + + // rejected_handlers.disable + // fulfilled_handlers.disable + tuples[ 3 - i ][ 3 ].disable, + + // progress_callbacks.lock + tuples[ 0 ][ 2 ].lock, + + // progress_handlers.lock + tuples[ 0 ][ 3 ].lock + ); + } + + // progress_handlers.fire + // fulfilled_handlers.fire + // rejected_handlers.fire + list.add( tuple[ 3 ].fire ); + + // deferred.notify = function() { deferred.notifyWith(...) } + // deferred.resolve = function() { deferred.resolveWith(...) } + // deferred.reject = function() { deferred.rejectWith(...) } + deferred[ tuple[ 0 ] ] = function() { + deferred[ tuple[ 0 ] + "With" ]( this === deferred ? undefined : this, arguments ); + return this; + }; + + // deferred.notifyWith = list.fireWith + // deferred.resolveWith = list.fireWith + // deferred.rejectWith = list.fireWith + deferred[ tuple[ 0 ] + "With" ] = list.fireWith; + } ); + + // Make the deferred a promise + promise.promise( deferred ); + + // Call given func if any + if ( func ) { + func.call( deferred, deferred ); + } + + // All done! + return deferred; + }, + + // Deferred helper + when: function( singleValue ) { + var + + // count of uncompleted subordinates + remaining = arguments.length, + + // count of unprocessed arguments + i = remaining, + + // subordinate fulfillment data + resolveContexts = Array( i ), + resolveValues = slice.call( arguments ), + + // the primary Deferred + primary = jQuery.Deferred(), + + // subordinate callback factory + updateFunc = function( i ) { + return function( value ) { + resolveContexts[ i ] = this; + resolveValues[ i ] = arguments.length > 1 ? slice.call( arguments ) : value; + if ( !( --remaining ) ) { + primary.resolveWith( resolveContexts, resolveValues ); + } + }; + }; + + // Single- and empty arguments are adopted like Promise.resolve + if ( remaining <= 1 ) { + adoptValue( singleValue, primary.done( updateFunc( i ) ).resolve, primary.reject, + !remaining ); + + // Use .then() to unwrap secondary thenables (cf. gh-3000) + if ( primary.state() === "pending" || + isFunction( resolveValues[ i ] && resolveValues[ i ].then ) ) { + + return primary.then(); + } + } + + // Multiple arguments are aggregated like Promise.all array elements + while ( i-- ) { + adoptValue( resolveValues[ i ], updateFunc( i ), primary.reject ); + } + + return primary.promise(); + } +} ); + + +// These usually indicate a programmer mistake during development, +// warn about them ASAP rather than swallowing them by default. +var rerrorNames = /^(Eval|Internal|Range|Reference|Syntax|Type|URI)Error$/; + +jQuery.Deferred.exceptionHook = function( error, stack ) { + + // Support: IE 8 - 9 only + // Console exists when dev tools are open, which can happen at any time + if ( window.console && window.console.warn && error && rerrorNames.test( error.name ) ) { + window.console.warn( "jQuery.Deferred exception: " + error.message, error.stack, stack ); + } +}; + + + + +jQuery.readyException = function( error ) { + window.setTimeout( function() { + throw error; + } ); +}; + + + + +// The deferred used on DOM ready +var readyList = jQuery.Deferred(); + +jQuery.fn.ready = function( fn ) { + + readyList + .then( fn ) + + // Wrap jQuery.readyException in a function so that the lookup + // happens at the time of error handling instead of callback + // registration. + .catch( function( error ) { + jQuery.readyException( error ); + } ); + + return this; +}; + +jQuery.extend( { + + // Is the DOM ready to be used? Set to true once it occurs. + isReady: false, + + // A counter to track how many items to wait for before + // the ready event fires. See #6781 + readyWait: 1, + + // Handle when the DOM is ready + ready: function( wait ) { + + // Abort if there are pending holds or we're already ready + if ( wait === true ? --jQuery.readyWait : jQuery.isReady ) { + return; + } + + // Remember that the DOM is ready + jQuery.isReady = true; + + // If a normal DOM Ready event fired, decrement, and wait if need be + if ( wait !== true && --jQuery.readyWait > 0 ) { + return; + } + + // If there are functions bound, to execute + readyList.resolveWith( document, [ jQuery ] ); + } +} ); + +jQuery.ready.then = readyList.then; + +// The ready event handler and self cleanup method +function completed() { + document.removeEventListener( "DOMContentLoaded", completed ); + window.removeEventListener( "load", completed ); + jQuery.ready(); +} + +// Catch cases where $(document).ready() is called +// after the browser event has already occurred. +// Support: IE <=9 - 10 only +// Older IE sometimes signals "interactive" too soon +if ( document.readyState === "complete" || + ( document.readyState !== "loading" && !document.documentElement.doScroll ) ) { + + // Handle it asynchronously to allow scripts the opportunity to delay ready + window.setTimeout( jQuery.ready ); + +} else { + + // Use the handy event callback + document.addEventListener( "DOMContentLoaded", completed ); + + // A fallback to window.onload, that will always work + window.addEventListener( "load", completed ); +} + + + + +// Multifunctional method to get and set values of a collection +// The value/s can optionally be executed if it's a function +var access = function( elems, fn, key, value, chainable, emptyGet, raw ) { + var i = 0, + len = elems.length, + bulk = key == null; + + // Sets many values + if ( toType( key ) === "object" ) { + chainable = true; + for ( i in key ) { + access( elems, fn, i, key[ i ], true, emptyGet, raw ); + } + + // Sets one value + } else if ( value !== undefined ) { + chainable = true; + + if ( !isFunction( value ) ) { + raw = true; + } + + if ( bulk ) { + + // Bulk operations run against the entire set + if ( raw ) { + fn.call( elems, value ); + fn = null; + + // ...except when executing function values + } else { + bulk = fn; + fn = function( elem, _key, value ) { + return bulk.call( jQuery( elem ), value ); + }; + } + } + + if ( fn ) { + for ( ; i < len; i++ ) { + fn( + elems[ i ], key, raw ? + value : + value.call( elems[ i ], i, fn( elems[ i ], key ) ) + ); + } + } + } + + if ( chainable ) { + return elems; + } + + // Gets + if ( bulk ) { + return fn.call( elems ); + } + + return len ? fn( elems[ 0 ], key ) : emptyGet; +}; + + +// Matches dashed string for camelizing +var rmsPrefix = /^-ms-/, + rdashAlpha = /-([a-z])/g; + +// Used by camelCase as callback to replace() +function fcamelCase( _all, letter ) { + return letter.toUpperCase(); +} + +// Convert dashed to camelCase; used by the css and data modules +// Support: IE <=9 - 11, Edge 12 - 15 +// Microsoft forgot to hump their vendor prefix (#9572) +function camelCase( string ) { + return string.replace( rmsPrefix, "ms-" ).replace( rdashAlpha, fcamelCase ); +} +var acceptData = function( owner ) { + + // Accepts only: + // - Node + // - Node.ELEMENT_NODE + // - Node.DOCUMENT_NODE + // - Object + // - Any + return owner.nodeType === 1 || owner.nodeType === 9 || !( +owner.nodeType ); +}; + + + + +function Data() { + this.expando = jQuery.expando + Data.uid++; +} + +Data.uid = 1; + +Data.prototype = { + + cache: function( owner ) { + + // Check if the owner object already has a cache + var value = owner[ this.expando ]; + + // If not, create one + if ( !value ) { + value = {}; + + // We can accept data for non-element nodes in modern browsers, + // but we should not, see #8335. + // Always return an empty object. + if ( acceptData( owner ) ) { + + // If it is a node unlikely to be stringify-ed or looped over + // use plain assignment + if ( owner.nodeType ) { + owner[ this.expando ] = value; + + // Otherwise secure it in a non-enumerable property + // configurable must be true to allow the property to be + // deleted when data is removed + } else { + Object.defineProperty( owner, this.expando, { + value: value, + configurable: true + } ); + } + } + } + + return value; + }, + set: function( owner, data, value ) { + var prop, + cache = this.cache( owner ); + + // Handle: [ owner, key, value ] args + // Always use camelCase key (gh-2257) + if ( typeof data === "string" ) { + cache[ camelCase( data ) ] = value; + + // Handle: [ owner, { properties } ] args + } else { + + // Copy the properties one-by-one to the cache object + for ( prop in data ) { + cache[ camelCase( prop ) ] = data[ prop ]; + } + } + return cache; + }, + get: function( owner, key ) { + return key === undefined ? + this.cache( owner ) : + + // Always use camelCase key (gh-2257) + owner[ this.expando ] && owner[ this.expando ][ camelCase( key ) ]; + }, + access: function( owner, key, value ) { + + // In cases where either: + // + // 1. No key was specified + // 2. A string key was specified, but no value provided + // + // Take the "read" path and allow the get method to determine + // which value to return, respectively either: + // + // 1. The entire cache object + // 2. The data stored at the key + // + if ( key === undefined || + ( ( key && typeof key === "string" ) && value === undefined ) ) { + + return this.get( owner, key ); + } + + // When the key is not a string, or both a key and value + // are specified, set or extend (existing objects) with either: + // + // 1. An object of properties + // 2. A key and value + // + this.set( owner, key, value ); + + // Since the "set" path can have two possible entry points + // return the expected data based on which path was taken[*] + return value !== undefined ? value : key; + }, + remove: function( owner, key ) { + var i, + cache = owner[ this.expando ]; + + if ( cache === undefined ) { + return; + } + + if ( key !== undefined ) { + + // Support array or space separated string of keys + if ( Array.isArray( key ) ) { + + // If key is an array of keys... + // We always set camelCase keys, so remove that. + key = key.map( camelCase ); + } else { + key = camelCase( key ); + + // If a key with the spaces exists, use it. + // Otherwise, create an array by matching non-whitespace + key = key in cache ? + [ key ] : + ( key.match( rnothtmlwhite ) || [] ); + } + + i = key.length; + + while ( i-- ) { + delete cache[ key[ i ] ]; + } + } + + // Remove the expando if there's no more data + if ( key === undefined || jQuery.isEmptyObject( cache ) ) { + + // Support: Chrome <=35 - 45 + // Webkit & Blink performance suffers when deleting properties + // from DOM nodes, so set to undefined instead + // https://bugs.chromium.org/p/chromium/issues/detail?id=378607 (bug restricted) + if ( owner.nodeType ) { + owner[ this.expando ] = undefined; + } else { + delete owner[ this.expando ]; + } + } + }, + hasData: function( owner ) { + var cache = owner[ this.expando ]; + return cache !== undefined && !jQuery.isEmptyObject( cache ); + } +}; +var dataPriv = new Data(); + +var dataUser = new Data(); + + + +// Implementation Summary +// +// 1. Enforce API surface and semantic compatibility with 1.9.x branch +// 2. Improve the module's maintainability by reducing the storage +// paths to a single mechanism. +// 3. Use the same single mechanism to support "private" and "user" data. +// 4. _Never_ expose "private" data to user code (TODO: Drop _data, _removeData) +// 5. Avoid exposing implementation details on user objects (eg. expando properties) +// 6. Provide a clear path for implementation upgrade to WeakMap in 2014 + +var rbrace = /^(?:\{[\w\W]*\}|\[[\w\W]*\])$/, + rmultiDash = /[A-Z]/g; + +function getData( data ) { + if ( data === "true" ) { + return true; + } + + if ( data === "false" ) { + return false; + } + + if ( data === "null" ) { + return null; + } + + // Only convert to a number if it doesn't change the string + if ( data === +data + "" ) { + return +data; + } + + if ( rbrace.test( data ) ) { + return JSON.parse( data ); + } + + return data; +} + +function dataAttr( elem, key, data ) { + var name; + + // If nothing was found internally, try to fetch any + // data from the HTML5 data-* attribute + if ( data === undefined && elem.nodeType === 1 ) { + name = "data-" + key.replace( rmultiDash, "-$&" ).toLowerCase(); + data = elem.getAttribute( name ); + + if ( typeof data === "string" ) { + try { + data = getData( data ); + } catch ( e ) {} + + // Make sure we set the data so it isn't changed later + dataUser.set( elem, key, data ); + } else { + data = undefined; + } + } + return data; +} + +jQuery.extend( { + hasData: function( elem ) { + return dataUser.hasData( elem ) || dataPriv.hasData( elem ); + }, + + data: function( elem, name, data ) { + return dataUser.access( elem, name, data ); + }, + + removeData: function( elem, name ) { + dataUser.remove( elem, name ); + }, + + // TODO: Now that all calls to _data and _removeData have been replaced + // with direct calls to dataPriv methods, these can be deprecated. + _data: function( elem, name, data ) { + return dataPriv.access( elem, name, data ); + }, + + _removeData: function( elem, name ) { + dataPriv.remove( elem, name ); + } +} ); + +jQuery.fn.extend( { + data: function( key, value ) { + var i, name, data, + elem = this[ 0 ], + attrs = elem && elem.attributes; + + // Gets all values + if ( key === undefined ) { + if ( this.length ) { + data = dataUser.get( elem ); + + if ( elem.nodeType === 1 && !dataPriv.get( elem, "hasDataAttrs" ) ) { + i = attrs.length; + while ( i-- ) { + + // Support: IE 11 only + // The attrs elements can be null (#14894) + if ( attrs[ i ] ) { + name = attrs[ i ].name; + if ( name.indexOf( "data-" ) === 0 ) { + name = camelCase( name.slice( 5 ) ); + dataAttr( elem, name, data[ name ] ); + } + } + } + dataPriv.set( elem, "hasDataAttrs", true ); + } + } + + return data; + } + + // Sets multiple values + if ( typeof key === "object" ) { + return this.each( function() { + dataUser.set( this, key ); + } ); + } + + return access( this, function( value ) { + var data; + + // The calling jQuery object (element matches) is not empty + // (and therefore has an element appears at this[ 0 ]) and the + // `value` parameter was not undefined. An empty jQuery object + // will result in `undefined` for elem = this[ 0 ] which will + // throw an exception if an attempt to read a data cache is made. + if ( elem && value === undefined ) { + + // Attempt to get data from the cache + // The key will always be camelCased in Data + data = dataUser.get( elem, key ); + if ( data !== undefined ) { + return data; + } + + // Attempt to "discover" the data in + // HTML5 custom data-* attrs + data = dataAttr( elem, key ); + if ( data !== undefined ) { + return data; + } + + // We tried really hard, but the data doesn't exist. + return; + } + + // Set the data... + this.each( function() { + + // We always store the camelCased key + dataUser.set( this, key, value ); + } ); + }, null, value, arguments.length > 1, null, true ); + }, + + removeData: function( key ) { + return this.each( function() { + dataUser.remove( this, key ); + } ); + } +} ); + + +jQuery.extend( { + queue: function( elem, type, data ) { + var queue; + + if ( elem ) { + type = ( type || "fx" ) + "queue"; + queue = dataPriv.get( elem, type ); + + // Speed up dequeue by getting out quickly if this is just a lookup + if ( data ) { + if ( !queue || Array.isArray( data ) ) { + queue = dataPriv.access( elem, type, jQuery.makeArray( data ) ); + } else { + queue.push( data ); + } + } + return queue || []; + } + }, + + dequeue: function( elem, type ) { + type = type || "fx"; + + var queue = jQuery.queue( elem, type ), + startLength = queue.length, + fn = queue.shift(), + hooks = jQuery._queueHooks( elem, type ), + next = function() { + jQuery.dequeue( elem, type ); + }; + + // If the fx queue is dequeued, always remove the progress sentinel + if ( fn === "inprogress" ) { + fn = queue.shift(); + startLength--; + } + + if ( fn ) { + + // Add a progress sentinel to prevent the fx queue from being + // automatically dequeued + if ( type === "fx" ) { + queue.unshift( "inprogress" ); + } + + // Clear up the last queue stop function + delete hooks.stop; + fn.call( elem, next, hooks ); + } + + if ( !startLength && hooks ) { + hooks.empty.fire(); + } + }, + + // Not public - generate a queueHooks object, or return the current one + _queueHooks: function( elem, type ) { + var key = type + "queueHooks"; + return dataPriv.get( elem, key ) || dataPriv.access( elem, key, { + empty: jQuery.Callbacks( "once memory" ).add( function() { + dataPriv.remove( elem, [ type + "queue", key ] ); + } ) + } ); + } +} ); + +jQuery.fn.extend( { + queue: function( type, data ) { + var setter = 2; + + if ( typeof type !== "string" ) { + data = type; + type = "fx"; + setter--; + } + + if ( arguments.length < setter ) { + return jQuery.queue( this[ 0 ], type ); + } + + return data === undefined ? + this : + this.each( function() { + var queue = jQuery.queue( this, type, data ); + + // Ensure a hooks for this queue + jQuery._queueHooks( this, type ); + + if ( type === "fx" && queue[ 0 ] !== "inprogress" ) { + jQuery.dequeue( this, type ); + } + } ); + }, + dequeue: function( type ) { + return this.each( function() { + jQuery.dequeue( this, type ); + } ); + }, + clearQueue: function( type ) { + return this.queue( type || "fx", [] ); + }, + + // Get a promise resolved when queues of a certain type + // are emptied (fx is the type by default) + promise: function( type, obj ) { + var tmp, + count = 1, + defer = jQuery.Deferred(), + elements = this, + i = this.length, + resolve = function() { + if ( !( --count ) ) { + defer.resolveWith( elements, [ elements ] ); + } + }; + + if ( typeof type !== "string" ) { + obj = type; + type = undefined; + } + type = type || "fx"; + + while ( i-- ) { + tmp = dataPriv.get( elements[ i ], type + "queueHooks" ); + if ( tmp && tmp.empty ) { + count++; + tmp.empty.add( resolve ); + } + } + resolve(); + return defer.promise( obj ); + } +} ); +var pnum = ( /[+-]?(?:\d*\.|)\d+(?:[eE][+-]?\d+|)/ ).source; + +var rcssNum = new RegExp( "^(?:([+-])=|)(" + pnum + ")([a-z%]*)$", "i" ); + + +var cssExpand = [ "Top", "Right", "Bottom", "Left" ]; + +var documentElement = document.documentElement; + + + + var isAttached = function( elem ) { + return jQuery.contains( elem.ownerDocument, elem ); + }, + composed = { composed: true }; + + // Support: IE 9 - 11+, Edge 12 - 18+, iOS 10.0 - 10.2 only + // Check attachment across shadow DOM boundaries when possible (gh-3504) + // Support: iOS 10.0-10.2 only + // Early iOS 10 versions support `attachShadow` but not `getRootNode`, + // leading to errors. We need to check for `getRootNode`. + if ( documentElement.getRootNode ) { + isAttached = function( elem ) { + return jQuery.contains( elem.ownerDocument, elem ) || + elem.getRootNode( composed ) === elem.ownerDocument; + }; + } +var isHiddenWithinTree = function( elem, el ) { + + // isHiddenWithinTree might be called from jQuery#filter function; + // in that case, element will be second argument + elem = el || elem; + + // Inline style trumps all + return elem.style.display === "none" || + elem.style.display === "" && + + // Otherwise, check computed style + // Support: Firefox <=43 - 45 + // Disconnected elements can have computed display: none, so first confirm that elem is + // in the document. + isAttached( elem ) && + + jQuery.css( elem, "display" ) === "none"; + }; + + + +function adjustCSS( elem, prop, valueParts, tween ) { + var adjusted, scale, + maxIterations = 20, + currentValue = tween ? + function() { + return tween.cur(); + } : + function() { + return jQuery.css( elem, prop, "" ); + }, + initial = currentValue(), + unit = valueParts && valueParts[ 3 ] || ( jQuery.cssNumber[ prop ] ? "" : "px" ), + + // Starting value computation is required for potential unit mismatches + initialInUnit = elem.nodeType && + ( jQuery.cssNumber[ prop ] || unit !== "px" && +initial ) && + rcssNum.exec( jQuery.css( elem, prop ) ); + + if ( initialInUnit && initialInUnit[ 3 ] !== unit ) { + + // Support: Firefox <=54 + // Halve the iteration target value to prevent interference from CSS upper bounds (gh-2144) + initial = initial / 2; + + // Trust units reported by jQuery.css + unit = unit || initialInUnit[ 3 ]; + + // Iteratively approximate from a nonzero starting point + initialInUnit = +initial || 1; + + while ( maxIterations-- ) { + + // Evaluate and update our best guess (doubling guesses that zero out). + // Finish if the scale equals or crosses 1 (making the old*new product non-positive). + jQuery.style( elem, prop, initialInUnit + unit ); + if ( ( 1 - scale ) * ( 1 - ( scale = currentValue() / initial || 0.5 ) ) <= 0 ) { + maxIterations = 0; + } + initialInUnit = initialInUnit / scale; + + } + + initialInUnit = initialInUnit * 2; + jQuery.style( elem, prop, initialInUnit + unit ); + + // Make sure we update the tween properties later on + valueParts = valueParts || []; + } + + if ( valueParts ) { + initialInUnit = +initialInUnit || +initial || 0; + + // Apply relative offset (+=/-=) if specified + adjusted = valueParts[ 1 ] ? + initialInUnit + ( valueParts[ 1 ] + 1 ) * valueParts[ 2 ] : + +valueParts[ 2 ]; + if ( tween ) { + tween.unit = unit; + tween.start = initialInUnit; + tween.end = adjusted; + } + } + return adjusted; +} + + +var defaultDisplayMap = {}; + +function getDefaultDisplay( elem ) { + var temp, + doc = elem.ownerDocument, + nodeName = elem.nodeName, + display = defaultDisplayMap[ nodeName ]; + + if ( display ) { + return display; + } + + temp = doc.body.appendChild( doc.createElement( nodeName ) ); + display = jQuery.css( temp, "display" ); + + temp.parentNode.removeChild( temp ); + + if ( display === "none" ) { + display = "block"; + } + defaultDisplayMap[ nodeName ] = display; + + return display; +} + +function showHide( elements, show ) { + var display, elem, + values = [], + index = 0, + length = elements.length; + + // Determine new display value for elements that need to change + for ( ; index < length; index++ ) { + elem = elements[ index ]; + if ( !elem.style ) { + continue; + } + + display = elem.style.display; + if ( show ) { + + // Since we force visibility upon cascade-hidden elements, an immediate (and slow) + // check is required in this first loop unless we have a nonempty display value (either + // inline or about-to-be-restored) + if ( display === "none" ) { + values[ index ] = dataPriv.get( elem, "display" ) || null; + if ( !values[ index ] ) { + elem.style.display = ""; + } + } + if ( elem.style.display === "" && isHiddenWithinTree( elem ) ) { + values[ index ] = getDefaultDisplay( elem ); + } + } else { + if ( display !== "none" ) { + values[ index ] = "none"; + + // Remember what we're overwriting + dataPriv.set( elem, "display", display ); + } + } + } + + // Set the display of the elements in a second loop to avoid constant reflow + for ( index = 0; index < length; index++ ) { + if ( values[ index ] != null ) { + elements[ index ].style.display = values[ index ]; + } + } + + return elements; +} + +jQuery.fn.extend( { + show: function() { + return showHide( this, true ); + }, + hide: function() { + return showHide( this ); + }, + toggle: function( state ) { + if ( typeof state === "boolean" ) { + return state ? this.show() : this.hide(); + } + + return this.each( function() { + if ( isHiddenWithinTree( this ) ) { + jQuery( this ).show(); + } else { + jQuery( this ).hide(); + } + } ); + } +} ); +var rcheckableType = ( /^(?:checkbox|radio)$/i ); + +var rtagName = ( /<([a-z][^\/\0>\x20\t\r\n\f]*)/i ); + +var rscriptType = ( /^$|^module$|\/(?:java|ecma)script/i ); + + + +( function() { + var fragment = document.createDocumentFragment(), + div = fragment.appendChild( document.createElement( "div" ) ), + input = document.createElement( "input" ); + + // Support: Android 4.0 - 4.3 only + // Check state lost if the name is set (#11217) + // Support: Windows Web Apps (WWA) + // `name` and `type` must use .setAttribute for WWA (#14901) + input.setAttribute( "type", "radio" ); + input.setAttribute( "checked", "checked" ); + input.setAttribute( "name", "t" ); + + div.appendChild( input ); + + // Support: Android <=4.1 only + // Older WebKit doesn't clone checked state correctly in fragments + support.checkClone = div.cloneNode( true ).cloneNode( true ).lastChild.checked; + + // Support: IE <=11 only + // Make sure textarea (and checkbox) defaultValue is properly cloned + div.innerHTML = ""; + support.noCloneChecked = !!div.cloneNode( true ).lastChild.defaultValue; + + // Support: IE <=9 only + // IE <=9 replaces "; + support.option = !!div.lastChild; +} )(); + + +// We have to close these tags to support XHTML (#13200) +var wrapMap = { + + // XHTML parsers do not magically insert elements in the + // same way that tag soup parsers do. So we cannot shorten + // this by omitting or other required elements. + thead: [ 1, "", "
    " ], + col: [ 2, "", "
    " ], + tr: [ 2, "", "
    " ], + td: [ 3, "", "
    " ], + + _default: [ 0, "", "" ] +}; + +wrapMap.tbody = wrapMap.tfoot = wrapMap.colgroup = wrapMap.caption = wrapMap.thead; +wrapMap.th = wrapMap.td; + +// Support: IE <=9 only +if ( !support.option ) { + wrapMap.optgroup = wrapMap.option = [ 1, "" ]; +} + + +function getAll( context, tag ) { + + // Support: IE <=9 - 11 only + // Use typeof to avoid zero-argument method invocation on host objects (#15151) + var ret; + + if ( typeof context.getElementsByTagName !== "undefined" ) { + ret = context.getElementsByTagName( tag || "*" ); + + } else if ( typeof context.querySelectorAll !== "undefined" ) { + ret = context.querySelectorAll( tag || "*" ); + + } else { + ret = []; + } + + if ( tag === undefined || tag && nodeName( context, tag ) ) { + return jQuery.merge( [ context ], ret ); + } + + return ret; +} + + +// Mark scripts as having already been evaluated +function setGlobalEval( elems, refElements ) { + var i = 0, + l = elems.length; + + for ( ; i < l; i++ ) { + dataPriv.set( + elems[ i ], + "globalEval", + !refElements || dataPriv.get( refElements[ i ], "globalEval" ) + ); + } +} + + +var rhtml = /<|&#?\w+;/; + +function buildFragment( elems, context, scripts, selection, ignored ) { + var elem, tmp, tag, wrap, attached, j, + fragment = context.createDocumentFragment(), + nodes = [], + i = 0, + l = elems.length; + + for ( ; i < l; i++ ) { + elem = elems[ i ]; + + if ( elem || elem === 0 ) { + + // Add nodes directly + if ( toType( elem ) === "object" ) { + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + jQuery.merge( nodes, elem.nodeType ? [ elem ] : elem ); + + // Convert non-html into a text node + } else if ( !rhtml.test( elem ) ) { + nodes.push( context.createTextNode( elem ) ); + + // Convert html into DOM nodes + } else { + tmp = tmp || fragment.appendChild( context.createElement( "div" ) ); + + // Deserialize a standard representation + tag = ( rtagName.exec( elem ) || [ "", "" ] )[ 1 ].toLowerCase(); + wrap = wrapMap[ tag ] || wrapMap._default; + tmp.innerHTML = wrap[ 1 ] + jQuery.htmlPrefilter( elem ) + wrap[ 2 ]; + + // Descend through wrappers to the right content + j = wrap[ 0 ]; + while ( j-- ) { + tmp = tmp.lastChild; + } + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + jQuery.merge( nodes, tmp.childNodes ); + + // Remember the top-level container + tmp = fragment.firstChild; + + // Ensure the created nodes are orphaned (#12392) + tmp.textContent = ""; + } + } + } + + // Remove wrapper from fragment + fragment.textContent = ""; + + i = 0; + while ( ( elem = nodes[ i++ ] ) ) { + + // Skip elements already in the context collection (trac-4087) + if ( selection && jQuery.inArray( elem, selection ) > -1 ) { + if ( ignored ) { + ignored.push( elem ); + } + continue; + } + + attached = isAttached( elem ); + + // Append to fragment + tmp = getAll( fragment.appendChild( elem ), "script" ); + + // Preserve script evaluation history + if ( attached ) { + setGlobalEval( tmp ); + } + + // Capture executables + if ( scripts ) { + j = 0; + while ( ( elem = tmp[ j++ ] ) ) { + if ( rscriptType.test( elem.type || "" ) ) { + scripts.push( elem ); + } + } + } + } + + return fragment; +} + + +var rtypenamespace = /^([^.]*)(?:\.(.+)|)/; + +function returnTrue() { + return true; +} + +function returnFalse() { + return false; +} + +// Support: IE <=9 - 11+ +// focus() and blur() are asynchronous, except when they are no-op. +// So expect focus to be synchronous when the element is already active, +// and blur to be synchronous when the element is not already active. +// (focus and blur are always synchronous in other supported browsers, +// this just defines when we can count on it). +function expectSync( elem, type ) { + return ( elem === safeActiveElement() ) === ( type === "focus" ); +} + +// Support: IE <=9 only +// Accessing document.activeElement can throw unexpectedly +// https://bugs.jquery.com/ticket/13393 +function safeActiveElement() { + try { + return document.activeElement; + } catch ( err ) { } +} + +function on( elem, types, selector, data, fn, one ) { + var origFn, type; + + // Types can be a map of types/handlers + if ( typeof types === "object" ) { + + // ( types-Object, selector, data ) + if ( typeof selector !== "string" ) { + + // ( types-Object, data ) + data = data || selector; + selector = undefined; + } + for ( type in types ) { + on( elem, type, selector, data, types[ type ], one ); + } + return elem; + } + + if ( data == null && fn == null ) { + + // ( types, fn ) + fn = selector; + data = selector = undefined; + } else if ( fn == null ) { + if ( typeof selector === "string" ) { + + // ( types, selector, fn ) + fn = data; + data = undefined; + } else { + + // ( types, data, fn ) + fn = data; + data = selector; + selector = undefined; + } + } + if ( fn === false ) { + fn = returnFalse; + } else if ( !fn ) { + return elem; + } + + if ( one === 1 ) { + origFn = fn; + fn = function( event ) { + + // Can use an empty set, since event contains the info + jQuery().off( event ); + return origFn.apply( this, arguments ); + }; + + // Use same guid so caller can remove using origFn + fn.guid = origFn.guid || ( origFn.guid = jQuery.guid++ ); + } + return elem.each( function() { + jQuery.event.add( this, types, fn, data, selector ); + } ); +} + +/* + * Helper functions for managing events -- not part of the public interface. + * Props to Dean Edwards' addEvent library for many of the ideas. + */ +jQuery.event = { + + global: {}, + + add: function( elem, types, handler, data, selector ) { + + var handleObjIn, eventHandle, tmp, + events, t, handleObj, + special, handlers, type, namespaces, origType, + elemData = dataPriv.get( elem ); + + // Only attach events to objects that accept data + if ( !acceptData( elem ) ) { + return; + } + + // Caller can pass in an object of custom data in lieu of the handler + if ( handler.handler ) { + handleObjIn = handler; + handler = handleObjIn.handler; + selector = handleObjIn.selector; + } + + // Ensure that invalid selectors throw exceptions at attach time + // Evaluate against documentElement in case elem is a non-element node (e.g., document) + if ( selector ) { + jQuery.find.matchesSelector( documentElement, selector ); + } + + // Make sure that the handler has a unique ID, used to find/remove it later + if ( !handler.guid ) { + handler.guid = jQuery.guid++; + } + + // Init the element's event structure and main handler, if this is the first + if ( !( events = elemData.events ) ) { + events = elemData.events = Object.create( null ); + } + if ( !( eventHandle = elemData.handle ) ) { + eventHandle = elemData.handle = function( e ) { + + // Discard the second event of a jQuery.event.trigger() and + // when an event is called after a page has unloaded + return typeof jQuery !== "undefined" && jQuery.event.triggered !== e.type ? + jQuery.event.dispatch.apply( elem, arguments ) : undefined; + }; + } + + // Handle multiple events separated by a space + types = ( types || "" ).match( rnothtmlwhite ) || [ "" ]; + t = types.length; + while ( t-- ) { + tmp = rtypenamespace.exec( types[ t ] ) || []; + type = origType = tmp[ 1 ]; + namespaces = ( tmp[ 2 ] || "" ).split( "." ).sort(); + + // There *must* be a type, no attaching namespace-only handlers + if ( !type ) { + continue; + } + + // If event changes its type, use the special event handlers for the changed type + special = jQuery.event.special[ type ] || {}; + + // If selector defined, determine special event api type, otherwise given type + type = ( selector ? special.delegateType : special.bindType ) || type; + + // Update special based on newly reset type + special = jQuery.event.special[ type ] || {}; + + // handleObj is passed to all event handlers + handleObj = jQuery.extend( { + type: type, + origType: origType, + data: data, + handler: handler, + guid: handler.guid, + selector: selector, + needsContext: selector && jQuery.expr.match.needsContext.test( selector ), + namespace: namespaces.join( "." ) + }, handleObjIn ); + + // Init the event handler queue if we're the first + if ( !( handlers = events[ type ] ) ) { + handlers = events[ type ] = []; + handlers.delegateCount = 0; + + // Only use addEventListener if the special events handler returns false + if ( !special.setup || + special.setup.call( elem, data, namespaces, eventHandle ) === false ) { + + if ( elem.addEventListener ) { + elem.addEventListener( type, eventHandle ); + } + } + } + + if ( special.add ) { + special.add.call( elem, handleObj ); + + if ( !handleObj.handler.guid ) { + handleObj.handler.guid = handler.guid; + } + } + + // Add to the element's handler list, delegates in front + if ( selector ) { + handlers.splice( handlers.delegateCount++, 0, handleObj ); + } else { + handlers.push( handleObj ); + } + + // Keep track of which events have ever been used, for event optimization + jQuery.event.global[ type ] = true; + } + + }, + + // Detach an event or set of events from an element + remove: function( elem, types, handler, selector, mappedTypes ) { + + var j, origCount, tmp, + events, t, handleObj, + special, handlers, type, namespaces, origType, + elemData = dataPriv.hasData( elem ) && dataPriv.get( elem ); + + if ( !elemData || !( events = elemData.events ) ) { + return; + } + + // Once for each type.namespace in types; type may be omitted + types = ( types || "" ).match( rnothtmlwhite ) || [ "" ]; + t = types.length; + while ( t-- ) { + tmp = rtypenamespace.exec( types[ t ] ) || []; + type = origType = tmp[ 1 ]; + namespaces = ( tmp[ 2 ] || "" ).split( "." ).sort(); + + // Unbind all events (on this namespace, if provided) for the element + if ( !type ) { + for ( type in events ) { + jQuery.event.remove( elem, type + types[ t ], handler, selector, true ); + } + continue; + } + + special = jQuery.event.special[ type ] || {}; + type = ( selector ? special.delegateType : special.bindType ) || type; + handlers = events[ type ] || []; + tmp = tmp[ 2 ] && + new RegExp( "(^|\\.)" + namespaces.join( "\\.(?:.*\\.|)" ) + "(\\.|$)" ); + + // Remove matching events + origCount = j = handlers.length; + while ( j-- ) { + handleObj = handlers[ j ]; + + if ( ( mappedTypes || origType === handleObj.origType ) && + ( !handler || handler.guid === handleObj.guid ) && + ( !tmp || tmp.test( handleObj.namespace ) ) && + ( !selector || selector === handleObj.selector || + selector === "**" && handleObj.selector ) ) { + handlers.splice( j, 1 ); + + if ( handleObj.selector ) { + handlers.delegateCount--; + } + if ( special.remove ) { + special.remove.call( elem, handleObj ); + } + } + } + + // Remove generic event handler if we removed something and no more handlers exist + // (avoids potential for endless recursion during removal of special event handlers) + if ( origCount && !handlers.length ) { + if ( !special.teardown || + special.teardown.call( elem, namespaces, elemData.handle ) === false ) { + + jQuery.removeEvent( elem, type, elemData.handle ); + } + + delete events[ type ]; + } + } + + // Remove data and the expando if it's no longer used + if ( jQuery.isEmptyObject( events ) ) { + dataPriv.remove( elem, "handle events" ); + } + }, + + dispatch: function( nativeEvent ) { + + var i, j, ret, matched, handleObj, handlerQueue, + args = new Array( arguments.length ), + + // Make a writable jQuery.Event from the native event object + event = jQuery.event.fix( nativeEvent ), + + handlers = ( + dataPriv.get( this, "events" ) || Object.create( null ) + )[ event.type ] || [], + special = jQuery.event.special[ event.type ] || {}; + + // Use the fix-ed jQuery.Event rather than the (read-only) native event + args[ 0 ] = event; + + for ( i = 1; i < arguments.length; i++ ) { + args[ i ] = arguments[ i ]; + } + + event.delegateTarget = this; + + // Call the preDispatch hook for the mapped type, and let it bail if desired + if ( special.preDispatch && special.preDispatch.call( this, event ) === false ) { + return; + } + + // Determine handlers + handlerQueue = jQuery.event.handlers.call( this, event, handlers ); + + // Run delegates first; they may want to stop propagation beneath us + i = 0; + while ( ( matched = handlerQueue[ i++ ] ) && !event.isPropagationStopped() ) { + event.currentTarget = matched.elem; + + j = 0; + while ( ( handleObj = matched.handlers[ j++ ] ) && + !event.isImmediatePropagationStopped() ) { + + // If the event is namespaced, then each handler is only invoked if it is + // specially universal or its namespaces are a superset of the event's. + if ( !event.rnamespace || handleObj.namespace === false || + event.rnamespace.test( handleObj.namespace ) ) { + + event.handleObj = handleObj; + event.data = handleObj.data; + + ret = ( ( jQuery.event.special[ handleObj.origType ] || {} ).handle || + handleObj.handler ).apply( matched.elem, args ); + + if ( ret !== undefined ) { + if ( ( event.result = ret ) === false ) { + event.preventDefault(); + event.stopPropagation(); + } + } + } + } + } + + // Call the postDispatch hook for the mapped type + if ( special.postDispatch ) { + special.postDispatch.call( this, event ); + } + + return event.result; + }, + + handlers: function( event, handlers ) { + var i, handleObj, sel, matchedHandlers, matchedSelectors, + handlerQueue = [], + delegateCount = handlers.delegateCount, + cur = event.target; + + // Find delegate handlers + if ( delegateCount && + + // Support: IE <=9 + // Black-hole SVG instance trees (trac-13180) + cur.nodeType && + + // Support: Firefox <=42 + // Suppress spec-violating clicks indicating a non-primary pointer button (trac-3861) + // https://www.w3.org/TR/DOM-Level-3-Events/#event-type-click + // Support: IE 11 only + // ...but not arrow key "clicks" of radio inputs, which can have `button` -1 (gh-2343) + !( event.type === "click" && event.button >= 1 ) ) { + + for ( ; cur !== this; cur = cur.parentNode || this ) { + + // Don't check non-elements (#13208) + // Don't process clicks on disabled elements (#6911, #8165, #11382, #11764) + if ( cur.nodeType === 1 && !( event.type === "click" && cur.disabled === true ) ) { + matchedHandlers = []; + matchedSelectors = {}; + for ( i = 0; i < delegateCount; i++ ) { + handleObj = handlers[ i ]; + + // Don't conflict with Object.prototype properties (#13203) + sel = handleObj.selector + " "; + + if ( matchedSelectors[ sel ] === undefined ) { + matchedSelectors[ sel ] = handleObj.needsContext ? + jQuery( sel, this ).index( cur ) > -1 : + jQuery.find( sel, this, null, [ cur ] ).length; + } + if ( matchedSelectors[ sel ] ) { + matchedHandlers.push( handleObj ); + } + } + if ( matchedHandlers.length ) { + handlerQueue.push( { elem: cur, handlers: matchedHandlers } ); + } + } + } + } + + // Add the remaining (directly-bound) handlers + cur = this; + if ( delegateCount < handlers.length ) { + handlerQueue.push( { elem: cur, handlers: handlers.slice( delegateCount ) } ); + } + + return handlerQueue; + }, + + addProp: function( name, hook ) { + Object.defineProperty( jQuery.Event.prototype, name, { + enumerable: true, + configurable: true, + + get: isFunction( hook ) ? + function() { + if ( this.originalEvent ) { + return hook( this.originalEvent ); + } + } : + function() { + if ( this.originalEvent ) { + return this.originalEvent[ name ]; + } + }, + + set: function( value ) { + Object.defineProperty( this, name, { + enumerable: true, + configurable: true, + writable: true, + value: value + } ); + } + } ); + }, + + fix: function( originalEvent ) { + return originalEvent[ jQuery.expando ] ? + originalEvent : + new jQuery.Event( originalEvent ); + }, + + special: { + load: { + + // Prevent triggered image.load events from bubbling to window.load + noBubble: true + }, + click: { + + // Utilize native event to ensure correct state for checkable inputs + setup: function( data ) { + + // For mutual compressibility with _default, replace `this` access with a local var. + // `|| data` is dead code meant only to preserve the variable through minification. + var el = this || data; + + // Claim the first handler + if ( rcheckableType.test( el.type ) && + el.click && nodeName( el, "input" ) ) { + + // dataPriv.set( el, "click", ... ) + leverageNative( el, "click", returnTrue ); + } + + // Return false to allow normal processing in the caller + return false; + }, + trigger: function( data ) { + + // For mutual compressibility with _default, replace `this` access with a local var. + // `|| data` is dead code meant only to preserve the variable through minification. + var el = this || data; + + // Force setup before triggering a click + if ( rcheckableType.test( el.type ) && + el.click && nodeName( el, "input" ) ) { + + leverageNative( el, "click" ); + } + + // Return non-false to allow normal event-path propagation + return true; + }, + + // For cross-browser consistency, suppress native .click() on links + // Also prevent it if we're currently inside a leveraged native-event stack + _default: function( event ) { + var target = event.target; + return rcheckableType.test( target.type ) && + target.click && nodeName( target, "input" ) && + dataPriv.get( target, "click" ) || + nodeName( target, "a" ); + } + }, + + beforeunload: { + postDispatch: function( event ) { + + // Support: Firefox 20+ + // Firefox doesn't alert if the returnValue field is not set. + if ( event.result !== undefined && event.originalEvent ) { + event.originalEvent.returnValue = event.result; + } + } + } + } +}; + +// Ensure the presence of an event listener that handles manually-triggered +// synthetic events by interrupting progress until reinvoked in response to +// *native* events that it fires directly, ensuring that state changes have +// already occurred before other listeners are invoked. +function leverageNative( el, type, expectSync ) { + + // Missing expectSync indicates a trigger call, which must force setup through jQuery.event.add + if ( !expectSync ) { + if ( dataPriv.get( el, type ) === undefined ) { + jQuery.event.add( el, type, returnTrue ); + } + return; + } + + // Register the controller as a special universal handler for all event namespaces + dataPriv.set( el, type, false ); + jQuery.event.add( el, type, { + namespace: false, + handler: function( event ) { + var notAsync, result, + saved = dataPriv.get( this, type ); + + if ( ( event.isTrigger & 1 ) && this[ type ] ) { + + // Interrupt processing of the outer synthetic .trigger()ed event + // Saved data should be false in such cases, but might be a leftover capture object + // from an async native handler (gh-4350) + if ( !saved.length ) { + + // Store arguments for use when handling the inner native event + // There will always be at least one argument (an event object), so this array + // will not be confused with a leftover capture object. + saved = slice.call( arguments ); + dataPriv.set( this, type, saved ); + + // Trigger the native event and capture its result + // Support: IE <=9 - 11+ + // focus() and blur() are asynchronous + notAsync = expectSync( this, type ); + this[ type ](); + result = dataPriv.get( this, type ); + if ( saved !== result || notAsync ) { + dataPriv.set( this, type, false ); + } else { + result = {}; + } + if ( saved !== result ) { + + // Cancel the outer synthetic event + event.stopImmediatePropagation(); + event.preventDefault(); + + // Support: Chrome 86+ + // In Chrome, if an element having a focusout handler is blurred by + // clicking outside of it, it invokes the handler synchronously. If + // that handler calls `.remove()` on the element, the data is cleared, + // leaving `result` undefined. We need to guard against this. + return result && result.value; + } + + // If this is an inner synthetic event for an event with a bubbling surrogate + // (focus or blur), assume that the surrogate already propagated from triggering the + // native event and prevent that from happening again here. + // This technically gets the ordering wrong w.r.t. to `.trigger()` (in which the + // bubbling surrogate propagates *after* the non-bubbling base), but that seems + // less bad than duplication. + } else if ( ( jQuery.event.special[ type ] || {} ).delegateType ) { + event.stopPropagation(); + } + + // If this is a native event triggered above, everything is now in order + // Fire an inner synthetic event with the original arguments + } else if ( saved.length ) { + + // ...and capture the result + dataPriv.set( this, type, { + value: jQuery.event.trigger( + + // Support: IE <=9 - 11+ + // Extend with the prototype to reset the above stopImmediatePropagation() + jQuery.extend( saved[ 0 ], jQuery.Event.prototype ), + saved.slice( 1 ), + this + ) + } ); + + // Abort handling of the native event + event.stopImmediatePropagation(); + } + } + } ); +} + +jQuery.removeEvent = function( elem, type, handle ) { + + // This "if" is needed for plain objects + if ( elem.removeEventListener ) { + elem.removeEventListener( type, handle ); + } +}; + +jQuery.Event = function( src, props ) { + + // Allow instantiation without the 'new' keyword + if ( !( this instanceof jQuery.Event ) ) { + return new jQuery.Event( src, props ); + } + + // Event object + if ( src && src.type ) { + this.originalEvent = src; + this.type = src.type; + + // Events bubbling up the document may have been marked as prevented + // by a handler lower down the tree; reflect the correct value. + this.isDefaultPrevented = src.defaultPrevented || + src.defaultPrevented === undefined && + + // Support: Android <=2.3 only + src.returnValue === false ? + returnTrue : + returnFalse; + + // Create target properties + // Support: Safari <=6 - 7 only + // Target should not be a text node (#504, #13143) + this.target = ( src.target && src.target.nodeType === 3 ) ? + src.target.parentNode : + src.target; + + this.currentTarget = src.currentTarget; + this.relatedTarget = src.relatedTarget; + + // Event type + } else { + this.type = src; + } + + // Put explicitly provided properties onto the event object + if ( props ) { + jQuery.extend( this, props ); + } + + // Create a timestamp if incoming event doesn't have one + this.timeStamp = src && src.timeStamp || Date.now(); + + // Mark it as fixed + this[ jQuery.expando ] = true; +}; + +// jQuery.Event is based on DOM3 Events as specified by the ECMAScript Language Binding +// https://www.w3.org/TR/2003/WD-DOM-Level-3-Events-20030331/ecma-script-binding.html +jQuery.Event.prototype = { + constructor: jQuery.Event, + isDefaultPrevented: returnFalse, + isPropagationStopped: returnFalse, + isImmediatePropagationStopped: returnFalse, + isSimulated: false, + + preventDefault: function() { + var e = this.originalEvent; + + this.isDefaultPrevented = returnTrue; + + if ( e && !this.isSimulated ) { + e.preventDefault(); + } + }, + stopPropagation: function() { + var e = this.originalEvent; + + this.isPropagationStopped = returnTrue; + + if ( e && !this.isSimulated ) { + e.stopPropagation(); + } + }, + stopImmediatePropagation: function() { + var e = this.originalEvent; + + this.isImmediatePropagationStopped = returnTrue; + + if ( e && !this.isSimulated ) { + e.stopImmediatePropagation(); + } + + this.stopPropagation(); + } +}; + +// Includes all common event props including KeyEvent and MouseEvent specific props +jQuery.each( { + altKey: true, + bubbles: true, + cancelable: true, + changedTouches: true, + ctrlKey: true, + detail: true, + eventPhase: true, + metaKey: true, + pageX: true, + pageY: true, + shiftKey: true, + view: true, + "char": true, + code: true, + charCode: true, + key: true, + keyCode: true, + button: true, + buttons: true, + clientX: true, + clientY: true, + offsetX: true, + offsetY: true, + pointerId: true, + pointerType: true, + screenX: true, + screenY: true, + targetTouches: true, + toElement: true, + touches: true, + which: true +}, jQuery.event.addProp ); + +jQuery.each( { focus: "focusin", blur: "focusout" }, function( type, delegateType ) { + jQuery.event.special[ type ] = { + + // Utilize native event if possible so blur/focus sequence is correct + setup: function() { + + // Claim the first handler + // dataPriv.set( this, "focus", ... ) + // dataPriv.set( this, "blur", ... ) + leverageNative( this, type, expectSync ); + + // Return false to allow normal processing in the caller + return false; + }, + trigger: function() { + + // Force setup before trigger + leverageNative( this, type ); + + // Return non-false to allow normal event-path propagation + return true; + }, + + // Suppress native focus or blur as it's already being fired + // in leverageNative. + _default: function() { + return true; + }, + + delegateType: delegateType + }; +} ); + +// Create mouseenter/leave events using mouseover/out and event-time checks +// so that event delegation works in jQuery. +// Do the same for pointerenter/pointerleave and pointerover/pointerout +// +// Support: Safari 7 only +// Safari sends mouseenter too often; see: +// https://bugs.chromium.org/p/chromium/issues/detail?id=470258 +// for the description of the bug (it existed in older Chrome versions as well). +jQuery.each( { + mouseenter: "mouseover", + mouseleave: "mouseout", + pointerenter: "pointerover", + pointerleave: "pointerout" +}, function( orig, fix ) { + jQuery.event.special[ orig ] = { + delegateType: fix, + bindType: fix, + + handle: function( event ) { + var ret, + target = this, + related = event.relatedTarget, + handleObj = event.handleObj; + + // For mouseenter/leave call the handler if related is outside the target. + // NB: No relatedTarget if the mouse left/entered the browser window + if ( !related || ( related !== target && !jQuery.contains( target, related ) ) ) { + event.type = handleObj.origType; + ret = handleObj.handler.apply( this, arguments ); + event.type = fix; + } + return ret; + } + }; +} ); + +jQuery.fn.extend( { + + on: function( types, selector, data, fn ) { + return on( this, types, selector, data, fn ); + }, + one: function( types, selector, data, fn ) { + return on( this, types, selector, data, fn, 1 ); + }, + off: function( types, selector, fn ) { + var handleObj, type; + if ( types && types.preventDefault && types.handleObj ) { + + // ( event ) dispatched jQuery.Event + handleObj = types.handleObj; + jQuery( types.delegateTarget ).off( + handleObj.namespace ? + handleObj.origType + "." + handleObj.namespace : + handleObj.origType, + handleObj.selector, + handleObj.handler + ); + return this; + } + if ( typeof types === "object" ) { + + // ( types-object [, selector] ) + for ( type in types ) { + this.off( type, selector, types[ type ] ); + } + return this; + } + if ( selector === false || typeof selector === "function" ) { + + // ( types [, fn] ) + fn = selector; + selector = undefined; + } + if ( fn === false ) { + fn = returnFalse; + } + return this.each( function() { + jQuery.event.remove( this, types, fn, selector ); + } ); + } +} ); + + +var + + // Support: IE <=10 - 11, Edge 12 - 13 only + // In IE/Edge using regex groups here causes severe slowdowns. + // See https://connect.microsoft.com/IE/feedback/details/1736512/ + rnoInnerhtml = /\s*$/g; + +// Prefer a tbody over its parent table for containing new rows +function manipulationTarget( elem, content ) { + if ( nodeName( elem, "table" ) && + nodeName( content.nodeType !== 11 ? content : content.firstChild, "tr" ) ) { + + return jQuery( elem ).children( "tbody" )[ 0 ] || elem; + } + + return elem; +} + +// Replace/restore the type attribute of script elements for safe DOM manipulation +function disableScript( elem ) { + elem.type = ( elem.getAttribute( "type" ) !== null ) + "/" + elem.type; + return elem; +} +function restoreScript( elem ) { + if ( ( elem.type || "" ).slice( 0, 5 ) === "true/" ) { + elem.type = elem.type.slice( 5 ); + } else { + elem.removeAttribute( "type" ); + } + + return elem; +} + +function cloneCopyEvent( src, dest ) { + var i, l, type, pdataOld, udataOld, udataCur, events; + + if ( dest.nodeType !== 1 ) { + return; + } + + // 1. Copy private data: events, handlers, etc. + if ( dataPriv.hasData( src ) ) { + pdataOld = dataPriv.get( src ); + events = pdataOld.events; + + if ( events ) { + dataPriv.remove( dest, "handle events" ); + + for ( type in events ) { + for ( i = 0, l = events[ type ].length; i < l; i++ ) { + jQuery.event.add( dest, type, events[ type ][ i ] ); + } + } + } + } + + // 2. Copy user data + if ( dataUser.hasData( src ) ) { + udataOld = dataUser.access( src ); + udataCur = jQuery.extend( {}, udataOld ); + + dataUser.set( dest, udataCur ); + } +} + +// Fix IE bugs, see support tests +function fixInput( src, dest ) { + var nodeName = dest.nodeName.toLowerCase(); + + // Fails to persist the checked state of a cloned checkbox or radio button. + if ( nodeName === "input" && rcheckableType.test( src.type ) ) { + dest.checked = src.checked; + + // Fails to return the selected option to the default selected state when cloning options + } else if ( nodeName === "input" || nodeName === "textarea" ) { + dest.defaultValue = src.defaultValue; + } +} + +function domManip( collection, args, callback, ignored ) { + + // Flatten any nested arrays + args = flat( args ); + + var fragment, first, scripts, hasScripts, node, doc, + i = 0, + l = collection.length, + iNoClone = l - 1, + value = args[ 0 ], + valueIsFunction = isFunction( value ); + + // We can't cloneNode fragments that contain checked, in WebKit + if ( valueIsFunction || + ( l > 1 && typeof value === "string" && + !support.checkClone && rchecked.test( value ) ) ) { + return collection.each( function( index ) { + var self = collection.eq( index ); + if ( valueIsFunction ) { + args[ 0 ] = value.call( this, index, self.html() ); + } + domManip( self, args, callback, ignored ); + } ); + } + + if ( l ) { + fragment = buildFragment( args, collection[ 0 ].ownerDocument, false, collection, ignored ); + first = fragment.firstChild; + + if ( fragment.childNodes.length === 1 ) { + fragment = first; + } + + // Require either new content or an interest in ignored elements to invoke the callback + if ( first || ignored ) { + scripts = jQuery.map( getAll( fragment, "script" ), disableScript ); + hasScripts = scripts.length; + + // Use the original fragment for the last item + // instead of the first because it can end up + // being emptied incorrectly in certain situations (#8070). + for ( ; i < l; i++ ) { + node = fragment; + + if ( i !== iNoClone ) { + node = jQuery.clone( node, true, true ); + + // Keep references to cloned scripts for later restoration + if ( hasScripts ) { + + // Support: Android <=4.0 only, PhantomJS 1 only + // push.apply(_, arraylike) throws on ancient WebKit + jQuery.merge( scripts, getAll( node, "script" ) ); + } + } + + callback.call( collection[ i ], node, i ); + } + + if ( hasScripts ) { + doc = scripts[ scripts.length - 1 ].ownerDocument; + + // Reenable scripts + jQuery.map( scripts, restoreScript ); + + // Evaluate executable scripts on first document insertion + for ( i = 0; i < hasScripts; i++ ) { + node = scripts[ i ]; + if ( rscriptType.test( node.type || "" ) && + !dataPriv.access( node, "globalEval" ) && + jQuery.contains( doc, node ) ) { + + if ( node.src && ( node.type || "" ).toLowerCase() !== "module" ) { + + // Optional AJAX dependency, but won't run scripts if not present + if ( jQuery._evalUrl && !node.noModule ) { + jQuery._evalUrl( node.src, { + nonce: node.nonce || node.getAttribute( "nonce" ) + }, doc ); + } + } else { + DOMEval( node.textContent.replace( rcleanScript, "" ), node, doc ); + } + } + } + } + } + } + + return collection; +} + +function remove( elem, selector, keepData ) { + var node, + nodes = selector ? jQuery.filter( selector, elem ) : elem, + i = 0; + + for ( ; ( node = nodes[ i ] ) != null; i++ ) { + if ( !keepData && node.nodeType === 1 ) { + jQuery.cleanData( getAll( node ) ); + } + + if ( node.parentNode ) { + if ( keepData && isAttached( node ) ) { + setGlobalEval( getAll( node, "script" ) ); + } + node.parentNode.removeChild( node ); + } + } + + return elem; +} + +jQuery.extend( { + htmlPrefilter: function( html ) { + return html; + }, + + clone: function( elem, dataAndEvents, deepDataAndEvents ) { + var i, l, srcElements, destElements, + clone = elem.cloneNode( true ), + inPage = isAttached( elem ); + + // Fix IE cloning issues + if ( !support.noCloneChecked && ( elem.nodeType === 1 || elem.nodeType === 11 ) && + !jQuery.isXMLDoc( elem ) ) { + + // We eschew Sizzle here for performance reasons: https://jsperf.com/getall-vs-sizzle/2 + destElements = getAll( clone ); + srcElements = getAll( elem ); + + for ( i = 0, l = srcElements.length; i < l; i++ ) { + fixInput( srcElements[ i ], destElements[ i ] ); + } + } + + // Copy the events from the original to the clone + if ( dataAndEvents ) { + if ( deepDataAndEvents ) { + srcElements = srcElements || getAll( elem ); + destElements = destElements || getAll( clone ); + + for ( i = 0, l = srcElements.length; i < l; i++ ) { + cloneCopyEvent( srcElements[ i ], destElements[ i ] ); + } + } else { + cloneCopyEvent( elem, clone ); + } + } + + // Preserve script evaluation history + destElements = getAll( clone, "script" ); + if ( destElements.length > 0 ) { + setGlobalEval( destElements, !inPage && getAll( elem, "script" ) ); + } + + // Return the cloned set + return clone; + }, + + cleanData: function( elems ) { + var data, elem, type, + special = jQuery.event.special, + i = 0; + + for ( ; ( elem = elems[ i ] ) !== undefined; i++ ) { + if ( acceptData( elem ) ) { + if ( ( data = elem[ dataPriv.expando ] ) ) { + if ( data.events ) { + for ( type in data.events ) { + if ( special[ type ] ) { + jQuery.event.remove( elem, type ); + + // This is a shortcut to avoid jQuery.event.remove's overhead + } else { + jQuery.removeEvent( elem, type, data.handle ); + } + } + } + + // Support: Chrome <=35 - 45+ + // Assign undefined instead of using delete, see Data#remove + elem[ dataPriv.expando ] = undefined; + } + if ( elem[ dataUser.expando ] ) { + + // Support: Chrome <=35 - 45+ + // Assign undefined instead of using delete, see Data#remove + elem[ dataUser.expando ] = undefined; + } + } + } + } +} ); + +jQuery.fn.extend( { + detach: function( selector ) { + return remove( this, selector, true ); + }, + + remove: function( selector ) { + return remove( this, selector ); + }, + + text: function( value ) { + return access( this, function( value ) { + return value === undefined ? + jQuery.text( this ) : + this.empty().each( function() { + if ( this.nodeType === 1 || this.nodeType === 11 || this.nodeType === 9 ) { + this.textContent = value; + } + } ); + }, null, value, arguments.length ); + }, + + append: function() { + return domManip( this, arguments, function( elem ) { + if ( this.nodeType === 1 || this.nodeType === 11 || this.nodeType === 9 ) { + var target = manipulationTarget( this, elem ); + target.appendChild( elem ); + } + } ); + }, + + prepend: function() { + return domManip( this, arguments, function( elem ) { + if ( this.nodeType === 1 || this.nodeType === 11 || this.nodeType === 9 ) { + var target = manipulationTarget( this, elem ); + target.insertBefore( elem, target.firstChild ); + } + } ); + }, + + before: function() { + return domManip( this, arguments, function( elem ) { + if ( this.parentNode ) { + this.parentNode.insertBefore( elem, this ); + } + } ); + }, + + after: function() { + return domManip( this, arguments, function( elem ) { + if ( this.parentNode ) { + this.parentNode.insertBefore( elem, this.nextSibling ); + } + } ); + }, + + empty: function() { + var elem, + i = 0; + + for ( ; ( elem = this[ i ] ) != null; i++ ) { + if ( elem.nodeType === 1 ) { + + // Prevent memory leaks + jQuery.cleanData( getAll( elem, false ) ); + + // Remove any remaining nodes + elem.textContent = ""; + } + } + + return this; + }, + + clone: function( dataAndEvents, deepDataAndEvents ) { + dataAndEvents = dataAndEvents == null ? false : dataAndEvents; + deepDataAndEvents = deepDataAndEvents == null ? dataAndEvents : deepDataAndEvents; + + return this.map( function() { + return jQuery.clone( this, dataAndEvents, deepDataAndEvents ); + } ); + }, + + html: function( value ) { + return access( this, function( value ) { + var elem = this[ 0 ] || {}, + i = 0, + l = this.length; + + if ( value === undefined && elem.nodeType === 1 ) { + return elem.innerHTML; + } + + // See if we can take a shortcut and just use innerHTML + if ( typeof value === "string" && !rnoInnerhtml.test( value ) && + !wrapMap[ ( rtagName.exec( value ) || [ "", "" ] )[ 1 ].toLowerCase() ] ) { + + value = jQuery.htmlPrefilter( value ); + + try { + for ( ; i < l; i++ ) { + elem = this[ i ] || {}; + + // Remove element nodes and prevent memory leaks + if ( elem.nodeType === 1 ) { + jQuery.cleanData( getAll( elem, false ) ); + elem.innerHTML = value; + } + } + + elem = 0; + + // If using innerHTML throws an exception, use the fallback method + } catch ( e ) {} + } + + if ( elem ) { + this.empty().append( value ); + } + }, null, value, arguments.length ); + }, + + replaceWith: function() { + var ignored = []; + + // Make the changes, replacing each non-ignored context element with the new content + return domManip( this, arguments, function( elem ) { + var parent = this.parentNode; + + if ( jQuery.inArray( this, ignored ) < 0 ) { + jQuery.cleanData( getAll( this ) ); + if ( parent ) { + parent.replaceChild( elem, this ); + } + } + + // Force callback invocation + }, ignored ); + } +} ); + +jQuery.each( { + appendTo: "append", + prependTo: "prepend", + insertBefore: "before", + insertAfter: "after", + replaceAll: "replaceWith" +}, function( name, original ) { + jQuery.fn[ name ] = function( selector ) { + var elems, + ret = [], + insert = jQuery( selector ), + last = insert.length - 1, + i = 0; + + for ( ; i <= last; i++ ) { + elems = i === last ? this : this.clone( true ); + jQuery( insert[ i ] )[ original ]( elems ); + + // Support: Android <=4.0 only, PhantomJS 1 only + // .get() because push.apply(_, arraylike) throws on ancient WebKit + push.apply( ret, elems.get() ); + } + + return this.pushStack( ret ); + }; +} ); +var rnumnonpx = new RegExp( "^(" + pnum + ")(?!px)[a-z%]+$", "i" ); + +var getStyles = function( elem ) { + + // Support: IE <=11 only, Firefox <=30 (#15098, #14150) + // IE throws on elements created in popups + // FF meanwhile throws on frame elements through "defaultView.getComputedStyle" + var view = elem.ownerDocument.defaultView; + + if ( !view || !view.opener ) { + view = window; + } + + return view.getComputedStyle( elem ); + }; + +var swap = function( elem, options, callback ) { + var ret, name, + old = {}; + + // Remember the old values, and insert the new ones + for ( name in options ) { + old[ name ] = elem.style[ name ]; + elem.style[ name ] = options[ name ]; + } + + ret = callback.call( elem ); + + // Revert the old values + for ( name in options ) { + elem.style[ name ] = old[ name ]; + } + + return ret; +}; + + +var rboxStyle = new RegExp( cssExpand.join( "|" ), "i" ); + + + +( function() { + + // Executing both pixelPosition & boxSizingReliable tests require only one layout + // so they're executed at the same time to save the second computation. + function computeStyleTests() { + + // This is a singleton, we need to execute it only once + if ( !div ) { + return; + } + + container.style.cssText = "position:absolute;left:-11111px;width:60px;" + + "margin-top:1px;padding:0;border:0"; + div.style.cssText = + "position:relative;display:block;box-sizing:border-box;overflow:scroll;" + + "margin:auto;border:1px;padding:1px;" + + "width:60%;top:1%"; + documentElement.appendChild( container ).appendChild( div ); + + var divStyle = window.getComputedStyle( div ); + pixelPositionVal = divStyle.top !== "1%"; + + // Support: Android 4.0 - 4.3 only, Firefox <=3 - 44 + reliableMarginLeftVal = roundPixelMeasures( divStyle.marginLeft ) === 12; + + // Support: Android 4.0 - 4.3 only, Safari <=9.1 - 10.1, iOS <=7.0 - 9.3 + // Some styles come back with percentage values, even though they shouldn't + div.style.right = "60%"; + pixelBoxStylesVal = roundPixelMeasures( divStyle.right ) === 36; + + // Support: IE 9 - 11 only + // Detect misreporting of content dimensions for box-sizing:border-box elements + boxSizingReliableVal = roundPixelMeasures( divStyle.width ) === 36; + + // Support: IE 9 only + // Detect overflow:scroll screwiness (gh-3699) + // Support: Chrome <=64 + // Don't get tricked when zoom affects offsetWidth (gh-4029) + div.style.position = "absolute"; + scrollboxSizeVal = roundPixelMeasures( div.offsetWidth / 3 ) === 12; + + documentElement.removeChild( container ); + + // Nullify the div so it wouldn't be stored in the memory and + // it will also be a sign that checks already performed + div = null; + } + + function roundPixelMeasures( measure ) { + return Math.round( parseFloat( measure ) ); + } + + var pixelPositionVal, boxSizingReliableVal, scrollboxSizeVal, pixelBoxStylesVal, + reliableTrDimensionsVal, reliableMarginLeftVal, + container = document.createElement( "div" ), + div = document.createElement( "div" ); + + // Finish early in limited (non-browser) environments + if ( !div.style ) { + return; + } + + // Support: IE <=9 - 11 only + // Style of cloned element affects source element cloned (#8908) + div.style.backgroundClip = "content-box"; + div.cloneNode( true ).style.backgroundClip = ""; + support.clearCloneStyle = div.style.backgroundClip === "content-box"; + + jQuery.extend( support, { + boxSizingReliable: function() { + computeStyleTests(); + return boxSizingReliableVal; + }, + pixelBoxStyles: function() { + computeStyleTests(); + return pixelBoxStylesVal; + }, + pixelPosition: function() { + computeStyleTests(); + return pixelPositionVal; + }, + reliableMarginLeft: function() { + computeStyleTests(); + return reliableMarginLeftVal; + }, + scrollboxSize: function() { + computeStyleTests(); + return scrollboxSizeVal; + }, + + // Support: IE 9 - 11+, Edge 15 - 18+ + // IE/Edge misreport `getComputedStyle` of table rows with width/height + // set in CSS while `offset*` properties report correct values. + // Behavior in IE 9 is more subtle than in newer versions & it passes + // some versions of this test; make sure not to make it pass there! + // + // Support: Firefox 70+ + // Only Firefox includes border widths + // in computed dimensions. (gh-4529) + reliableTrDimensions: function() { + var table, tr, trChild, trStyle; + if ( reliableTrDimensionsVal == null ) { + table = document.createElement( "table" ); + tr = document.createElement( "tr" ); + trChild = document.createElement( "div" ); + + table.style.cssText = "position:absolute;left:-11111px;border-collapse:separate"; + tr.style.cssText = "border:1px solid"; + + // Support: Chrome 86+ + // Height set through cssText does not get applied. + // Computed height then comes back as 0. + tr.style.height = "1px"; + trChild.style.height = "9px"; + + // Support: Android 8 Chrome 86+ + // In our bodyBackground.html iframe, + // display for all div elements is set to "inline", + // which causes a problem only in Android 8 Chrome 86. + // Ensuring the div is display: block + // gets around this issue. + trChild.style.display = "block"; + + documentElement + .appendChild( table ) + .appendChild( tr ) + .appendChild( trChild ); + + trStyle = window.getComputedStyle( tr ); + reliableTrDimensionsVal = ( parseInt( trStyle.height, 10 ) + + parseInt( trStyle.borderTopWidth, 10 ) + + parseInt( trStyle.borderBottomWidth, 10 ) ) === tr.offsetHeight; + + documentElement.removeChild( table ); + } + return reliableTrDimensionsVal; + } + } ); +} )(); + + +function curCSS( elem, name, computed ) { + var width, minWidth, maxWidth, ret, + + // Support: Firefox 51+ + // Retrieving style before computed somehow + // fixes an issue with getting wrong values + // on detached elements + style = elem.style; + + computed = computed || getStyles( elem ); + + // getPropertyValue is needed for: + // .css('filter') (IE 9 only, #12537) + // .css('--customProperty) (#3144) + if ( computed ) { + ret = computed.getPropertyValue( name ) || computed[ name ]; + + if ( ret === "" && !isAttached( elem ) ) { + ret = jQuery.style( elem, name ); + } + + // A tribute to the "awesome hack by Dean Edwards" + // Android Browser returns percentage for some values, + // but width seems to be reliably pixels. + // This is against the CSSOM draft spec: + // https://drafts.csswg.org/cssom/#resolved-values + if ( !support.pixelBoxStyles() && rnumnonpx.test( ret ) && rboxStyle.test( name ) ) { + + // Remember the original values + width = style.width; + minWidth = style.minWidth; + maxWidth = style.maxWidth; + + // Put in the new values to get a computed value out + style.minWidth = style.maxWidth = style.width = ret; + ret = computed.width; + + // Revert the changed values + style.width = width; + style.minWidth = minWidth; + style.maxWidth = maxWidth; + } + } + + return ret !== undefined ? + + // Support: IE <=9 - 11 only + // IE returns zIndex value as an integer. + ret + "" : + ret; +} + + +function addGetHookIf( conditionFn, hookFn ) { + + // Define the hook, we'll check on the first run if it's really needed. + return { + get: function() { + if ( conditionFn() ) { + + // Hook not needed (or it's not possible to use it due + // to missing dependency), remove it. + delete this.get; + return; + } + + // Hook needed; redefine it so that the support test is not executed again. + return ( this.get = hookFn ).apply( this, arguments ); + } + }; +} + + +var cssPrefixes = [ "Webkit", "Moz", "ms" ], + emptyStyle = document.createElement( "div" ).style, + vendorProps = {}; + +// Return a vendor-prefixed property or undefined +function vendorPropName( name ) { + + // Check for vendor prefixed names + var capName = name[ 0 ].toUpperCase() + name.slice( 1 ), + i = cssPrefixes.length; + + while ( i-- ) { + name = cssPrefixes[ i ] + capName; + if ( name in emptyStyle ) { + return name; + } + } +} + +// Return a potentially-mapped jQuery.cssProps or vendor prefixed property +function finalPropName( name ) { + var final = jQuery.cssProps[ name ] || vendorProps[ name ]; + + if ( final ) { + return final; + } + if ( name in emptyStyle ) { + return name; + } + return vendorProps[ name ] = vendorPropName( name ) || name; +} + + +var + + // Swappable if display is none or starts with table + // except "table", "table-cell", or "table-caption" + // See here for display values: https://developer.mozilla.org/en-US/docs/CSS/display + rdisplayswap = /^(none|table(?!-c[ea]).+)/, + rcustomProp = /^--/, + cssShow = { position: "absolute", visibility: "hidden", display: "block" }, + cssNormalTransform = { + letterSpacing: "0", + fontWeight: "400" + }; + +function setPositiveNumber( _elem, value, subtract ) { + + // Any relative (+/-) values have already been + // normalized at this point + var matches = rcssNum.exec( value ); + return matches ? + + // Guard against undefined "subtract", e.g., when used as in cssHooks + Math.max( 0, matches[ 2 ] - ( subtract || 0 ) ) + ( matches[ 3 ] || "px" ) : + value; +} + +function boxModelAdjustment( elem, dimension, box, isBorderBox, styles, computedVal ) { + var i = dimension === "width" ? 1 : 0, + extra = 0, + delta = 0; + + // Adjustment may not be necessary + if ( box === ( isBorderBox ? "border" : "content" ) ) { + return 0; + } + + for ( ; i < 4; i += 2 ) { + + // Both box models exclude margin + if ( box === "margin" ) { + delta += jQuery.css( elem, box + cssExpand[ i ], true, styles ); + } + + // If we get here with a content-box, we're seeking "padding" or "border" or "margin" + if ( !isBorderBox ) { + + // Add padding + delta += jQuery.css( elem, "padding" + cssExpand[ i ], true, styles ); + + // For "border" or "margin", add border + if ( box !== "padding" ) { + delta += jQuery.css( elem, "border" + cssExpand[ i ] + "Width", true, styles ); + + // But still keep track of it otherwise + } else { + extra += jQuery.css( elem, "border" + cssExpand[ i ] + "Width", true, styles ); + } + + // If we get here with a border-box (content + padding + border), we're seeking "content" or + // "padding" or "margin" + } else { + + // For "content", subtract padding + if ( box === "content" ) { + delta -= jQuery.css( elem, "padding" + cssExpand[ i ], true, styles ); + } + + // For "content" or "padding", subtract border + if ( box !== "margin" ) { + delta -= jQuery.css( elem, "border" + cssExpand[ i ] + "Width", true, styles ); + } + } + } + + // Account for positive content-box scroll gutter when requested by providing computedVal + if ( !isBorderBox && computedVal >= 0 ) { + + // offsetWidth/offsetHeight is a rounded sum of content, padding, scroll gutter, and border + // Assuming integer scroll gutter, subtract the rest and round down + delta += Math.max( 0, Math.ceil( + elem[ "offset" + dimension[ 0 ].toUpperCase() + dimension.slice( 1 ) ] - + computedVal - + delta - + extra - + 0.5 + + // If offsetWidth/offsetHeight is unknown, then we can't determine content-box scroll gutter + // Use an explicit zero to avoid NaN (gh-3964) + ) ) || 0; + } + + return delta; +} + +function getWidthOrHeight( elem, dimension, extra ) { + + // Start with computed style + var styles = getStyles( elem ), + + // To avoid forcing a reflow, only fetch boxSizing if we need it (gh-4322). + // Fake content-box until we know it's needed to know the true value. + boxSizingNeeded = !support.boxSizingReliable() || extra, + isBorderBox = boxSizingNeeded && + jQuery.css( elem, "boxSizing", false, styles ) === "border-box", + valueIsBorderBox = isBorderBox, + + val = curCSS( elem, dimension, styles ), + offsetProp = "offset" + dimension[ 0 ].toUpperCase() + dimension.slice( 1 ); + + // Support: Firefox <=54 + // Return a confounding non-pixel value or feign ignorance, as appropriate. + if ( rnumnonpx.test( val ) ) { + if ( !extra ) { + return val; + } + val = "auto"; + } + + + // Support: IE 9 - 11 only + // Use offsetWidth/offsetHeight for when box sizing is unreliable. + // In those cases, the computed value can be trusted to be border-box. + if ( ( !support.boxSizingReliable() && isBorderBox || + + // Support: IE 10 - 11+, Edge 15 - 18+ + // IE/Edge misreport `getComputedStyle` of table rows with width/height + // set in CSS while `offset*` properties report correct values. + // Interestingly, in some cases IE 9 doesn't suffer from this issue. + !support.reliableTrDimensions() && nodeName( elem, "tr" ) || + + // Fall back to offsetWidth/offsetHeight when value is "auto" + // This happens for inline elements with no explicit setting (gh-3571) + val === "auto" || + + // Support: Android <=4.1 - 4.3 only + // Also use offsetWidth/offsetHeight for misreported inline dimensions (gh-3602) + !parseFloat( val ) && jQuery.css( elem, "display", false, styles ) === "inline" ) && + + // Make sure the element is visible & connected + elem.getClientRects().length ) { + + isBorderBox = jQuery.css( elem, "boxSizing", false, styles ) === "border-box"; + + // Where available, offsetWidth/offsetHeight approximate border box dimensions. + // Where not available (e.g., SVG), assume unreliable box-sizing and interpret the + // retrieved value as a content box dimension. + valueIsBorderBox = offsetProp in elem; + if ( valueIsBorderBox ) { + val = elem[ offsetProp ]; + } + } + + // Normalize "" and auto + val = parseFloat( val ) || 0; + + // Adjust for the element's box model + return ( val + + boxModelAdjustment( + elem, + dimension, + extra || ( isBorderBox ? "border" : "content" ), + valueIsBorderBox, + styles, + + // Provide the current computed size to request scroll gutter calculation (gh-3589) + val + ) + ) + "px"; +} + +jQuery.extend( { + + // Add in style property hooks for overriding the default + // behavior of getting and setting a style property + cssHooks: { + opacity: { + get: function( elem, computed ) { + if ( computed ) { + + // We should always get a number back from opacity + var ret = curCSS( elem, "opacity" ); + return ret === "" ? "1" : ret; + } + } + } + }, + + // Don't automatically add "px" to these possibly-unitless properties + cssNumber: { + "animationIterationCount": true, + "columnCount": true, + "fillOpacity": true, + "flexGrow": true, + "flexShrink": true, + "fontWeight": true, + "gridArea": true, + "gridColumn": true, + "gridColumnEnd": true, + "gridColumnStart": true, + "gridRow": true, + "gridRowEnd": true, + "gridRowStart": true, + "lineHeight": true, + "opacity": true, + "order": true, + "orphans": true, + "widows": true, + "zIndex": true, + "zoom": true + }, + + // Add in properties whose names you wish to fix before + // setting or getting the value + cssProps: {}, + + // Get and set the style property on a DOM Node + style: function( elem, name, value, extra ) { + + // Don't set styles on text and comment nodes + if ( !elem || elem.nodeType === 3 || elem.nodeType === 8 || !elem.style ) { + return; + } + + // Make sure that we're working with the right name + var ret, type, hooks, + origName = camelCase( name ), + isCustomProp = rcustomProp.test( name ), + style = elem.style; + + // Make sure that we're working with the right name. We don't + // want to query the value if it is a CSS custom property + // since they are user-defined. + if ( !isCustomProp ) { + name = finalPropName( origName ); + } + + // Gets hook for the prefixed version, then unprefixed version + hooks = jQuery.cssHooks[ name ] || jQuery.cssHooks[ origName ]; + + // Check if we're setting a value + if ( value !== undefined ) { + type = typeof value; + + // Convert "+=" or "-=" to relative numbers (#7345) + if ( type === "string" && ( ret = rcssNum.exec( value ) ) && ret[ 1 ] ) { + value = adjustCSS( elem, name, ret ); + + // Fixes bug #9237 + type = "number"; + } + + // Make sure that null and NaN values aren't set (#7116) + if ( value == null || value !== value ) { + return; + } + + // If a number was passed in, add the unit (except for certain CSS properties) + // The isCustomProp check can be removed in jQuery 4.0 when we only auto-append + // "px" to a few hardcoded values. + if ( type === "number" && !isCustomProp ) { + value += ret && ret[ 3 ] || ( jQuery.cssNumber[ origName ] ? "" : "px" ); + } + + // background-* props affect original clone's values + if ( !support.clearCloneStyle && value === "" && name.indexOf( "background" ) === 0 ) { + style[ name ] = "inherit"; + } + + // If a hook was provided, use that value, otherwise just set the specified value + if ( !hooks || !( "set" in hooks ) || + ( value = hooks.set( elem, value, extra ) ) !== undefined ) { + + if ( isCustomProp ) { + style.setProperty( name, value ); + } else { + style[ name ] = value; + } + } + + } else { + + // If a hook was provided get the non-computed value from there + if ( hooks && "get" in hooks && + ( ret = hooks.get( elem, false, extra ) ) !== undefined ) { + + return ret; + } + + // Otherwise just get the value from the style object + return style[ name ]; + } + }, + + css: function( elem, name, extra, styles ) { + var val, num, hooks, + origName = camelCase( name ), + isCustomProp = rcustomProp.test( name ); + + // Make sure that we're working with the right name. We don't + // want to modify the value if it is a CSS custom property + // since they are user-defined. + if ( !isCustomProp ) { + name = finalPropName( origName ); + } + + // Try prefixed name followed by the unprefixed name + hooks = jQuery.cssHooks[ name ] || jQuery.cssHooks[ origName ]; + + // If a hook was provided get the computed value from there + if ( hooks && "get" in hooks ) { + val = hooks.get( elem, true, extra ); + } + + // Otherwise, if a way to get the computed value exists, use that + if ( val === undefined ) { + val = curCSS( elem, name, styles ); + } + + // Convert "normal" to computed value + if ( val === "normal" && name in cssNormalTransform ) { + val = cssNormalTransform[ name ]; + } + + // Make numeric if forced or a qualifier was provided and val looks numeric + if ( extra === "" || extra ) { + num = parseFloat( val ); + return extra === true || isFinite( num ) ? num || 0 : val; + } + + return val; + } +} ); + +jQuery.each( [ "height", "width" ], function( _i, dimension ) { + jQuery.cssHooks[ dimension ] = { + get: function( elem, computed, extra ) { + if ( computed ) { + + // Certain elements can have dimension info if we invisibly show them + // but it must have a current display style that would benefit + return rdisplayswap.test( jQuery.css( elem, "display" ) ) && + + // Support: Safari 8+ + // Table columns in Safari have non-zero offsetWidth & zero + // getBoundingClientRect().width unless display is changed. + // Support: IE <=11 only + // Running getBoundingClientRect on a disconnected node + // in IE throws an error. + ( !elem.getClientRects().length || !elem.getBoundingClientRect().width ) ? + swap( elem, cssShow, function() { + return getWidthOrHeight( elem, dimension, extra ); + } ) : + getWidthOrHeight( elem, dimension, extra ); + } + }, + + set: function( elem, value, extra ) { + var matches, + styles = getStyles( elem ), + + // Only read styles.position if the test has a chance to fail + // to avoid forcing a reflow. + scrollboxSizeBuggy = !support.scrollboxSize() && + styles.position === "absolute", + + // To avoid forcing a reflow, only fetch boxSizing if we need it (gh-3991) + boxSizingNeeded = scrollboxSizeBuggy || extra, + isBorderBox = boxSizingNeeded && + jQuery.css( elem, "boxSizing", false, styles ) === "border-box", + subtract = extra ? + boxModelAdjustment( + elem, + dimension, + extra, + isBorderBox, + styles + ) : + 0; + + // Account for unreliable border-box dimensions by comparing offset* to computed and + // faking a content-box to get border and padding (gh-3699) + if ( isBorderBox && scrollboxSizeBuggy ) { + subtract -= Math.ceil( + elem[ "offset" + dimension[ 0 ].toUpperCase() + dimension.slice( 1 ) ] - + parseFloat( styles[ dimension ] ) - + boxModelAdjustment( elem, dimension, "border", false, styles ) - + 0.5 + ); + } + + // Convert to pixels if value adjustment is needed + if ( subtract && ( matches = rcssNum.exec( value ) ) && + ( matches[ 3 ] || "px" ) !== "px" ) { + + elem.style[ dimension ] = value; + value = jQuery.css( elem, dimension ); + } + + return setPositiveNumber( elem, value, subtract ); + } + }; +} ); + +jQuery.cssHooks.marginLeft = addGetHookIf( support.reliableMarginLeft, + function( elem, computed ) { + if ( computed ) { + return ( parseFloat( curCSS( elem, "marginLeft" ) ) || + elem.getBoundingClientRect().left - + swap( elem, { marginLeft: 0 }, function() { + return elem.getBoundingClientRect().left; + } ) + ) + "px"; + } + } +); + +// These hooks are used by animate to expand properties +jQuery.each( { + margin: "", + padding: "", + border: "Width" +}, function( prefix, suffix ) { + jQuery.cssHooks[ prefix + suffix ] = { + expand: function( value ) { + var i = 0, + expanded = {}, + + // Assumes a single number if not a string + parts = typeof value === "string" ? value.split( " " ) : [ value ]; + + for ( ; i < 4; i++ ) { + expanded[ prefix + cssExpand[ i ] + suffix ] = + parts[ i ] || parts[ i - 2 ] || parts[ 0 ]; + } + + return expanded; + } + }; + + if ( prefix !== "margin" ) { + jQuery.cssHooks[ prefix + suffix ].set = setPositiveNumber; + } +} ); + +jQuery.fn.extend( { + css: function( name, value ) { + return access( this, function( elem, name, value ) { + var styles, len, + map = {}, + i = 0; + + if ( Array.isArray( name ) ) { + styles = getStyles( elem ); + len = name.length; + + for ( ; i < len; i++ ) { + map[ name[ i ] ] = jQuery.css( elem, name[ i ], false, styles ); + } + + return map; + } + + return value !== undefined ? + jQuery.style( elem, name, value ) : + jQuery.css( elem, name ); + }, name, value, arguments.length > 1 ); + } +} ); + + +function Tween( elem, options, prop, end, easing ) { + return new Tween.prototype.init( elem, options, prop, end, easing ); +} +jQuery.Tween = Tween; + +Tween.prototype = { + constructor: Tween, + init: function( elem, options, prop, end, easing, unit ) { + this.elem = elem; + this.prop = prop; + this.easing = easing || jQuery.easing._default; + this.options = options; + this.start = this.now = this.cur(); + this.end = end; + this.unit = unit || ( jQuery.cssNumber[ prop ] ? "" : "px" ); + }, + cur: function() { + var hooks = Tween.propHooks[ this.prop ]; + + return hooks && hooks.get ? + hooks.get( this ) : + Tween.propHooks._default.get( this ); + }, + run: function( percent ) { + var eased, + hooks = Tween.propHooks[ this.prop ]; + + if ( this.options.duration ) { + this.pos = eased = jQuery.easing[ this.easing ]( + percent, this.options.duration * percent, 0, 1, this.options.duration + ); + } else { + this.pos = eased = percent; + } + this.now = ( this.end - this.start ) * eased + this.start; + + if ( this.options.step ) { + this.options.step.call( this.elem, this.now, this ); + } + + if ( hooks && hooks.set ) { + hooks.set( this ); + } else { + Tween.propHooks._default.set( this ); + } + return this; + } +}; + +Tween.prototype.init.prototype = Tween.prototype; + +Tween.propHooks = { + _default: { + get: function( tween ) { + var result; + + // Use a property on the element directly when it is not a DOM element, + // or when there is no matching style property that exists. + if ( tween.elem.nodeType !== 1 || + tween.elem[ tween.prop ] != null && tween.elem.style[ tween.prop ] == null ) { + return tween.elem[ tween.prop ]; + } + + // Passing an empty string as a 3rd parameter to .css will automatically + // attempt a parseFloat and fallback to a string if the parse fails. + // Simple values such as "10px" are parsed to Float; + // complex values such as "rotate(1rad)" are returned as-is. + result = jQuery.css( tween.elem, tween.prop, "" ); + + // Empty strings, null, undefined and "auto" are converted to 0. + return !result || result === "auto" ? 0 : result; + }, + set: function( tween ) { + + // Use step hook for back compat. + // Use cssHook if its there. + // Use .style if available and use plain properties where available. + if ( jQuery.fx.step[ tween.prop ] ) { + jQuery.fx.step[ tween.prop ]( tween ); + } else if ( tween.elem.nodeType === 1 && ( + jQuery.cssHooks[ tween.prop ] || + tween.elem.style[ finalPropName( tween.prop ) ] != null ) ) { + jQuery.style( tween.elem, tween.prop, tween.now + tween.unit ); + } else { + tween.elem[ tween.prop ] = tween.now; + } + } + } +}; + +// Support: IE <=9 only +// Panic based approach to setting things on disconnected nodes +Tween.propHooks.scrollTop = Tween.propHooks.scrollLeft = { + set: function( tween ) { + if ( tween.elem.nodeType && tween.elem.parentNode ) { + tween.elem[ tween.prop ] = tween.now; + } + } +}; + +jQuery.easing = { + linear: function( p ) { + return p; + }, + swing: function( p ) { + return 0.5 - Math.cos( p * Math.PI ) / 2; + }, + _default: "swing" +}; + +jQuery.fx = Tween.prototype.init; + +// Back compat <1.8 extension point +jQuery.fx.step = {}; + + + + +var + fxNow, inProgress, + rfxtypes = /^(?:toggle|show|hide)$/, + rrun = /queueHooks$/; + +function schedule() { + if ( inProgress ) { + if ( document.hidden === false && window.requestAnimationFrame ) { + window.requestAnimationFrame( schedule ); + } else { + window.setTimeout( schedule, jQuery.fx.interval ); + } + + jQuery.fx.tick(); + } +} + +// Animations created synchronously will run synchronously +function createFxNow() { + window.setTimeout( function() { + fxNow = undefined; + } ); + return ( fxNow = Date.now() ); +} + +// Generate parameters to create a standard animation +function genFx( type, includeWidth ) { + var which, + i = 0, + attrs = { height: type }; + + // If we include width, step value is 1 to do all cssExpand values, + // otherwise step value is 2 to skip over Left and Right + includeWidth = includeWidth ? 1 : 0; + for ( ; i < 4; i += 2 - includeWidth ) { + which = cssExpand[ i ]; + attrs[ "margin" + which ] = attrs[ "padding" + which ] = type; + } + + if ( includeWidth ) { + attrs.opacity = attrs.width = type; + } + + return attrs; +} + +function createTween( value, prop, animation ) { + var tween, + collection = ( Animation.tweeners[ prop ] || [] ).concat( Animation.tweeners[ "*" ] ), + index = 0, + length = collection.length; + for ( ; index < length; index++ ) { + if ( ( tween = collection[ index ].call( animation, prop, value ) ) ) { + + // We're done with this property + return tween; + } + } +} + +function defaultPrefilter( elem, props, opts ) { + var prop, value, toggle, hooks, oldfire, propTween, restoreDisplay, display, + isBox = "width" in props || "height" in props, + anim = this, + orig = {}, + style = elem.style, + hidden = elem.nodeType && isHiddenWithinTree( elem ), + dataShow = dataPriv.get( elem, "fxshow" ); + + // Queue-skipping animations hijack the fx hooks + if ( !opts.queue ) { + hooks = jQuery._queueHooks( elem, "fx" ); + if ( hooks.unqueued == null ) { + hooks.unqueued = 0; + oldfire = hooks.empty.fire; + hooks.empty.fire = function() { + if ( !hooks.unqueued ) { + oldfire(); + } + }; + } + hooks.unqueued++; + + anim.always( function() { + + // Ensure the complete handler is called before this completes + anim.always( function() { + hooks.unqueued--; + if ( !jQuery.queue( elem, "fx" ).length ) { + hooks.empty.fire(); + } + } ); + } ); + } + + // Detect show/hide animations + for ( prop in props ) { + value = props[ prop ]; + if ( rfxtypes.test( value ) ) { + delete props[ prop ]; + toggle = toggle || value === "toggle"; + if ( value === ( hidden ? "hide" : "show" ) ) { + + // Pretend to be hidden if this is a "show" and + // there is still data from a stopped show/hide + if ( value === "show" && dataShow && dataShow[ prop ] !== undefined ) { + hidden = true; + + // Ignore all other no-op show/hide data + } else { + continue; + } + } + orig[ prop ] = dataShow && dataShow[ prop ] || jQuery.style( elem, prop ); + } + } + + // Bail out if this is a no-op like .hide().hide() + propTween = !jQuery.isEmptyObject( props ); + if ( !propTween && jQuery.isEmptyObject( orig ) ) { + return; + } + + // Restrict "overflow" and "display" styles during box animations + if ( isBox && elem.nodeType === 1 ) { + + // Support: IE <=9 - 11, Edge 12 - 15 + // Record all 3 overflow attributes because IE does not infer the shorthand + // from identically-valued overflowX and overflowY and Edge just mirrors + // the overflowX value there. + opts.overflow = [ style.overflow, style.overflowX, style.overflowY ]; + + // Identify a display type, preferring old show/hide data over the CSS cascade + restoreDisplay = dataShow && dataShow.display; + if ( restoreDisplay == null ) { + restoreDisplay = dataPriv.get( elem, "display" ); + } + display = jQuery.css( elem, "display" ); + if ( display === "none" ) { + if ( restoreDisplay ) { + display = restoreDisplay; + } else { + + // Get nonempty value(s) by temporarily forcing visibility + showHide( [ elem ], true ); + restoreDisplay = elem.style.display || restoreDisplay; + display = jQuery.css( elem, "display" ); + showHide( [ elem ] ); + } + } + + // Animate inline elements as inline-block + if ( display === "inline" || display === "inline-block" && restoreDisplay != null ) { + if ( jQuery.css( elem, "float" ) === "none" ) { + + // Restore the original display value at the end of pure show/hide animations + if ( !propTween ) { + anim.done( function() { + style.display = restoreDisplay; + } ); + if ( restoreDisplay == null ) { + display = style.display; + restoreDisplay = display === "none" ? "" : display; + } + } + style.display = "inline-block"; + } + } + } + + if ( opts.overflow ) { + style.overflow = "hidden"; + anim.always( function() { + style.overflow = opts.overflow[ 0 ]; + style.overflowX = opts.overflow[ 1 ]; + style.overflowY = opts.overflow[ 2 ]; + } ); + } + + // Implement show/hide animations + propTween = false; + for ( prop in orig ) { + + // General show/hide setup for this element animation + if ( !propTween ) { + if ( dataShow ) { + if ( "hidden" in dataShow ) { + hidden = dataShow.hidden; + } + } else { + dataShow = dataPriv.access( elem, "fxshow", { display: restoreDisplay } ); + } + + // Store hidden/visible for toggle so `.stop().toggle()` "reverses" + if ( toggle ) { + dataShow.hidden = !hidden; + } + + // Show elements before animating them + if ( hidden ) { + showHide( [ elem ], true ); + } + + /* eslint-disable no-loop-func */ + + anim.done( function() { + + /* eslint-enable no-loop-func */ + + // The final step of a "hide" animation is actually hiding the element + if ( !hidden ) { + showHide( [ elem ] ); + } + dataPriv.remove( elem, "fxshow" ); + for ( prop in orig ) { + jQuery.style( elem, prop, orig[ prop ] ); + } + } ); + } + + // Per-property setup + propTween = createTween( hidden ? dataShow[ prop ] : 0, prop, anim ); + if ( !( prop in dataShow ) ) { + dataShow[ prop ] = propTween.start; + if ( hidden ) { + propTween.end = propTween.start; + propTween.start = 0; + } + } + } +} + +function propFilter( props, specialEasing ) { + var index, name, easing, value, hooks; + + // camelCase, specialEasing and expand cssHook pass + for ( index in props ) { + name = camelCase( index ); + easing = specialEasing[ name ]; + value = props[ index ]; + if ( Array.isArray( value ) ) { + easing = value[ 1 ]; + value = props[ index ] = value[ 0 ]; + } + + if ( index !== name ) { + props[ name ] = value; + delete props[ index ]; + } + + hooks = jQuery.cssHooks[ name ]; + if ( hooks && "expand" in hooks ) { + value = hooks.expand( value ); + delete props[ name ]; + + // Not quite $.extend, this won't overwrite existing keys. + // Reusing 'index' because we have the correct "name" + for ( index in value ) { + if ( !( index in props ) ) { + props[ index ] = value[ index ]; + specialEasing[ index ] = easing; + } + } + } else { + specialEasing[ name ] = easing; + } + } +} + +function Animation( elem, properties, options ) { + var result, + stopped, + index = 0, + length = Animation.prefilters.length, + deferred = jQuery.Deferred().always( function() { + + // Don't match elem in the :animated selector + delete tick.elem; + } ), + tick = function() { + if ( stopped ) { + return false; + } + var currentTime = fxNow || createFxNow(), + remaining = Math.max( 0, animation.startTime + animation.duration - currentTime ), + + // Support: Android 2.3 only + // Archaic crash bug won't allow us to use `1 - ( 0.5 || 0 )` (#12497) + temp = remaining / animation.duration || 0, + percent = 1 - temp, + index = 0, + length = animation.tweens.length; + + for ( ; index < length; index++ ) { + animation.tweens[ index ].run( percent ); + } + + deferred.notifyWith( elem, [ animation, percent, remaining ] ); + + // If there's more to do, yield + if ( percent < 1 && length ) { + return remaining; + } + + // If this was an empty animation, synthesize a final progress notification + if ( !length ) { + deferred.notifyWith( elem, [ animation, 1, 0 ] ); + } + + // Resolve the animation and report its conclusion + deferred.resolveWith( elem, [ animation ] ); + return false; + }, + animation = deferred.promise( { + elem: elem, + props: jQuery.extend( {}, properties ), + opts: jQuery.extend( true, { + specialEasing: {}, + easing: jQuery.easing._default + }, options ), + originalProperties: properties, + originalOptions: options, + startTime: fxNow || createFxNow(), + duration: options.duration, + tweens: [], + createTween: function( prop, end ) { + var tween = jQuery.Tween( elem, animation.opts, prop, end, + animation.opts.specialEasing[ prop ] || animation.opts.easing ); + animation.tweens.push( tween ); + return tween; + }, + stop: function( gotoEnd ) { + var index = 0, + + // If we are going to the end, we want to run all the tweens + // otherwise we skip this part + length = gotoEnd ? animation.tweens.length : 0; + if ( stopped ) { + return this; + } + stopped = true; + for ( ; index < length; index++ ) { + animation.tweens[ index ].run( 1 ); + } + + // Resolve when we played the last frame; otherwise, reject + if ( gotoEnd ) { + deferred.notifyWith( elem, [ animation, 1, 0 ] ); + deferred.resolveWith( elem, [ animation, gotoEnd ] ); + } else { + deferred.rejectWith( elem, [ animation, gotoEnd ] ); + } + return this; + } + } ), + props = animation.props; + + propFilter( props, animation.opts.specialEasing ); + + for ( ; index < length; index++ ) { + result = Animation.prefilters[ index ].call( animation, elem, props, animation.opts ); + if ( result ) { + if ( isFunction( result.stop ) ) { + jQuery._queueHooks( animation.elem, animation.opts.queue ).stop = + result.stop.bind( result ); + } + return result; + } + } + + jQuery.map( props, createTween, animation ); + + if ( isFunction( animation.opts.start ) ) { + animation.opts.start.call( elem, animation ); + } + + // Attach callbacks from options + animation + .progress( animation.opts.progress ) + .done( animation.opts.done, animation.opts.complete ) + .fail( animation.opts.fail ) + .always( animation.opts.always ); + + jQuery.fx.timer( + jQuery.extend( tick, { + elem: elem, + anim: animation, + queue: animation.opts.queue + } ) + ); + + return animation; +} + +jQuery.Animation = jQuery.extend( Animation, { + + tweeners: { + "*": [ function( prop, value ) { + var tween = this.createTween( prop, value ); + adjustCSS( tween.elem, prop, rcssNum.exec( value ), tween ); + return tween; + } ] + }, + + tweener: function( props, callback ) { + if ( isFunction( props ) ) { + callback = props; + props = [ "*" ]; + } else { + props = props.match( rnothtmlwhite ); + } + + var prop, + index = 0, + length = props.length; + + for ( ; index < length; index++ ) { + prop = props[ index ]; + Animation.tweeners[ prop ] = Animation.tweeners[ prop ] || []; + Animation.tweeners[ prop ].unshift( callback ); + } + }, + + prefilters: [ defaultPrefilter ], + + prefilter: function( callback, prepend ) { + if ( prepend ) { + Animation.prefilters.unshift( callback ); + } else { + Animation.prefilters.push( callback ); + } + } +} ); + +jQuery.speed = function( speed, easing, fn ) { + var opt = speed && typeof speed === "object" ? jQuery.extend( {}, speed ) : { + complete: fn || !fn && easing || + isFunction( speed ) && speed, + duration: speed, + easing: fn && easing || easing && !isFunction( easing ) && easing + }; + + // Go to the end state if fx are off + if ( jQuery.fx.off ) { + opt.duration = 0; + + } else { + if ( typeof opt.duration !== "number" ) { + if ( opt.duration in jQuery.fx.speeds ) { + opt.duration = jQuery.fx.speeds[ opt.duration ]; + + } else { + opt.duration = jQuery.fx.speeds._default; + } + } + } + + // Normalize opt.queue - true/undefined/null -> "fx" + if ( opt.queue == null || opt.queue === true ) { + opt.queue = "fx"; + } + + // Queueing + opt.old = opt.complete; + + opt.complete = function() { + if ( isFunction( opt.old ) ) { + opt.old.call( this ); + } + + if ( opt.queue ) { + jQuery.dequeue( this, opt.queue ); + } + }; + + return opt; +}; + +jQuery.fn.extend( { + fadeTo: function( speed, to, easing, callback ) { + + // Show any hidden elements after setting opacity to 0 + return this.filter( isHiddenWithinTree ).css( "opacity", 0 ).show() + + // Animate to the value specified + .end().animate( { opacity: to }, speed, easing, callback ); + }, + animate: function( prop, speed, easing, callback ) { + var empty = jQuery.isEmptyObject( prop ), + optall = jQuery.speed( speed, easing, callback ), + doAnimation = function() { + + // Operate on a copy of prop so per-property easing won't be lost + var anim = Animation( this, jQuery.extend( {}, prop ), optall ); + + // Empty animations, or finishing resolves immediately + if ( empty || dataPriv.get( this, "finish" ) ) { + anim.stop( true ); + } + }; + + doAnimation.finish = doAnimation; + + return empty || optall.queue === false ? + this.each( doAnimation ) : + this.queue( optall.queue, doAnimation ); + }, + stop: function( type, clearQueue, gotoEnd ) { + var stopQueue = function( hooks ) { + var stop = hooks.stop; + delete hooks.stop; + stop( gotoEnd ); + }; + + if ( typeof type !== "string" ) { + gotoEnd = clearQueue; + clearQueue = type; + type = undefined; + } + if ( clearQueue ) { + this.queue( type || "fx", [] ); + } + + return this.each( function() { + var dequeue = true, + index = type != null && type + "queueHooks", + timers = jQuery.timers, + data = dataPriv.get( this ); + + if ( index ) { + if ( data[ index ] && data[ index ].stop ) { + stopQueue( data[ index ] ); + } + } else { + for ( index in data ) { + if ( data[ index ] && data[ index ].stop && rrun.test( index ) ) { + stopQueue( data[ index ] ); + } + } + } + + for ( index = timers.length; index--; ) { + if ( timers[ index ].elem === this && + ( type == null || timers[ index ].queue === type ) ) { + + timers[ index ].anim.stop( gotoEnd ); + dequeue = false; + timers.splice( index, 1 ); + } + } + + // Start the next in the queue if the last step wasn't forced. + // Timers currently will call their complete callbacks, which + // will dequeue but only if they were gotoEnd. + if ( dequeue || !gotoEnd ) { + jQuery.dequeue( this, type ); + } + } ); + }, + finish: function( type ) { + if ( type !== false ) { + type = type || "fx"; + } + return this.each( function() { + var index, + data = dataPriv.get( this ), + queue = data[ type + "queue" ], + hooks = data[ type + "queueHooks" ], + timers = jQuery.timers, + length = queue ? queue.length : 0; + + // Enable finishing flag on private data + data.finish = true; + + // Empty the queue first + jQuery.queue( this, type, [] ); + + if ( hooks && hooks.stop ) { + hooks.stop.call( this, true ); + } + + // Look for any active animations, and finish them + for ( index = timers.length; index--; ) { + if ( timers[ index ].elem === this && timers[ index ].queue === type ) { + timers[ index ].anim.stop( true ); + timers.splice( index, 1 ); + } + } + + // Look for any animations in the old queue and finish them + for ( index = 0; index < length; index++ ) { + if ( queue[ index ] && queue[ index ].finish ) { + queue[ index ].finish.call( this ); + } + } + + // Turn off finishing flag + delete data.finish; + } ); + } +} ); + +jQuery.each( [ "toggle", "show", "hide" ], function( _i, name ) { + var cssFn = jQuery.fn[ name ]; + jQuery.fn[ name ] = function( speed, easing, callback ) { + return speed == null || typeof speed === "boolean" ? + cssFn.apply( this, arguments ) : + this.animate( genFx( name, true ), speed, easing, callback ); + }; +} ); + +// Generate shortcuts for custom animations +jQuery.each( { + slideDown: genFx( "show" ), + slideUp: genFx( "hide" ), + slideToggle: genFx( "toggle" ), + fadeIn: { opacity: "show" }, + fadeOut: { opacity: "hide" }, + fadeToggle: { opacity: "toggle" } +}, function( name, props ) { + jQuery.fn[ name ] = function( speed, easing, callback ) { + return this.animate( props, speed, easing, callback ); + }; +} ); + +jQuery.timers = []; +jQuery.fx.tick = function() { + var timer, + i = 0, + timers = jQuery.timers; + + fxNow = Date.now(); + + for ( ; i < timers.length; i++ ) { + timer = timers[ i ]; + + // Run the timer and safely remove it when done (allowing for external removal) + if ( !timer() && timers[ i ] === timer ) { + timers.splice( i--, 1 ); + } + } + + if ( !timers.length ) { + jQuery.fx.stop(); + } + fxNow = undefined; +}; + +jQuery.fx.timer = function( timer ) { + jQuery.timers.push( timer ); + jQuery.fx.start(); +}; + +jQuery.fx.interval = 13; +jQuery.fx.start = function() { + if ( inProgress ) { + return; + } + + inProgress = true; + schedule(); +}; + +jQuery.fx.stop = function() { + inProgress = null; +}; + +jQuery.fx.speeds = { + slow: 600, + fast: 200, + + // Default speed + _default: 400 +}; + + +// Based off of the plugin by Clint Helfers, with permission. +// https://web.archive.org/web/20100324014747/http://blindsignals.com/index.php/2009/07/jquery-delay/ +jQuery.fn.delay = function( time, type ) { + time = jQuery.fx ? jQuery.fx.speeds[ time ] || time : time; + type = type || "fx"; + + return this.queue( type, function( next, hooks ) { + var timeout = window.setTimeout( next, time ); + hooks.stop = function() { + window.clearTimeout( timeout ); + }; + } ); +}; + + +( function() { + var input = document.createElement( "input" ), + select = document.createElement( "select" ), + opt = select.appendChild( document.createElement( "option" ) ); + + input.type = "checkbox"; + + // Support: Android <=4.3 only + // Default value for a checkbox should be "on" + support.checkOn = input.value !== ""; + + // Support: IE <=11 only + // Must access selectedIndex to make default options select + support.optSelected = opt.selected; + + // Support: IE <=11 only + // An input loses its value after becoming a radio + input = document.createElement( "input" ); + input.value = "t"; + input.type = "radio"; + support.radioValue = input.value === "t"; +} )(); + + +var boolHook, + attrHandle = jQuery.expr.attrHandle; + +jQuery.fn.extend( { + attr: function( name, value ) { + return access( this, jQuery.attr, name, value, arguments.length > 1 ); + }, + + removeAttr: function( name ) { + return this.each( function() { + jQuery.removeAttr( this, name ); + } ); + } +} ); + +jQuery.extend( { + attr: function( elem, name, value ) { + var ret, hooks, + nType = elem.nodeType; + + // Don't get/set attributes on text, comment and attribute nodes + if ( nType === 3 || nType === 8 || nType === 2 ) { + return; + } + + // Fallback to prop when attributes are not supported + if ( typeof elem.getAttribute === "undefined" ) { + return jQuery.prop( elem, name, value ); + } + + // Attribute hooks are determined by the lowercase version + // Grab necessary hook if one is defined + if ( nType !== 1 || !jQuery.isXMLDoc( elem ) ) { + hooks = jQuery.attrHooks[ name.toLowerCase() ] || + ( jQuery.expr.match.bool.test( name ) ? boolHook : undefined ); + } + + if ( value !== undefined ) { + if ( value === null ) { + jQuery.removeAttr( elem, name ); + return; + } + + if ( hooks && "set" in hooks && + ( ret = hooks.set( elem, value, name ) ) !== undefined ) { + return ret; + } + + elem.setAttribute( name, value + "" ); + return value; + } + + if ( hooks && "get" in hooks && ( ret = hooks.get( elem, name ) ) !== null ) { + return ret; + } + + ret = jQuery.find.attr( elem, name ); + + // Non-existent attributes return null, we normalize to undefined + return ret == null ? undefined : ret; + }, + + attrHooks: { + type: { + set: function( elem, value ) { + if ( !support.radioValue && value === "radio" && + nodeName( elem, "input" ) ) { + var val = elem.value; + elem.setAttribute( "type", value ); + if ( val ) { + elem.value = val; + } + return value; + } + } + } + }, + + removeAttr: function( elem, value ) { + var name, + i = 0, + + // Attribute names can contain non-HTML whitespace characters + // https://html.spec.whatwg.org/multipage/syntax.html#attributes-2 + attrNames = value && value.match( rnothtmlwhite ); + + if ( attrNames && elem.nodeType === 1 ) { + while ( ( name = attrNames[ i++ ] ) ) { + elem.removeAttribute( name ); + } + } + } +} ); + +// Hooks for boolean attributes +boolHook = { + set: function( elem, value, name ) { + if ( value === false ) { + + // Remove boolean attributes when set to false + jQuery.removeAttr( elem, name ); + } else { + elem.setAttribute( name, name ); + } + return name; + } +}; + +jQuery.each( jQuery.expr.match.bool.source.match( /\w+/g ), function( _i, name ) { + var getter = attrHandle[ name ] || jQuery.find.attr; + + attrHandle[ name ] = function( elem, name, isXML ) { + var ret, handle, + lowercaseName = name.toLowerCase(); + + if ( !isXML ) { + + // Avoid an infinite loop by temporarily removing this function from the getter + handle = attrHandle[ lowercaseName ]; + attrHandle[ lowercaseName ] = ret; + ret = getter( elem, name, isXML ) != null ? + lowercaseName : + null; + attrHandle[ lowercaseName ] = handle; + } + return ret; + }; +} ); + + + + +var rfocusable = /^(?:input|select|textarea|button)$/i, + rclickable = /^(?:a|area)$/i; + +jQuery.fn.extend( { + prop: function( name, value ) { + return access( this, jQuery.prop, name, value, arguments.length > 1 ); + }, + + removeProp: function( name ) { + return this.each( function() { + delete this[ jQuery.propFix[ name ] || name ]; + } ); + } +} ); + +jQuery.extend( { + prop: function( elem, name, value ) { + var ret, hooks, + nType = elem.nodeType; + + // Don't get/set properties on text, comment and attribute nodes + if ( nType === 3 || nType === 8 || nType === 2 ) { + return; + } + + if ( nType !== 1 || !jQuery.isXMLDoc( elem ) ) { + + // Fix name and attach hooks + name = jQuery.propFix[ name ] || name; + hooks = jQuery.propHooks[ name ]; + } + + if ( value !== undefined ) { + if ( hooks && "set" in hooks && + ( ret = hooks.set( elem, value, name ) ) !== undefined ) { + return ret; + } + + return ( elem[ name ] = value ); + } + + if ( hooks && "get" in hooks && ( ret = hooks.get( elem, name ) ) !== null ) { + return ret; + } + + return elem[ name ]; + }, + + propHooks: { + tabIndex: { + get: function( elem ) { + + // Support: IE <=9 - 11 only + // elem.tabIndex doesn't always return the + // correct value when it hasn't been explicitly set + // https://web.archive.org/web/20141116233347/http://fluidproject.org/blog/2008/01/09/getting-setting-and-removing-tabindex-values-with-javascript/ + // Use proper attribute retrieval(#12072) + var tabindex = jQuery.find.attr( elem, "tabindex" ); + + if ( tabindex ) { + return parseInt( tabindex, 10 ); + } + + if ( + rfocusable.test( elem.nodeName ) || + rclickable.test( elem.nodeName ) && + elem.href + ) { + return 0; + } + + return -1; + } + } + }, + + propFix: { + "for": "htmlFor", + "class": "className" + } +} ); + +// Support: IE <=11 only +// Accessing the selectedIndex property +// forces the browser to respect setting selected +// on the option +// The getter ensures a default option is selected +// when in an optgroup +// eslint rule "no-unused-expressions" is disabled for this code +// since it considers such accessions noop +if ( !support.optSelected ) { + jQuery.propHooks.selected = { + get: function( elem ) { + + /* eslint no-unused-expressions: "off" */ + + var parent = elem.parentNode; + if ( parent && parent.parentNode ) { + parent.parentNode.selectedIndex; + } + return null; + }, + set: function( elem ) { + + /* eslint no-unused-expressions: "off" */ + + var parent = elem.parentNode; + if ( parent ) { + parent.selectedIndex; + + if ( parent.parentNode ) { + parent.parentNode.selectedIndex; + } + } + } + }; +} + +jQuery.each( [ + "tabIndex", + "readOnly", + "maxLength", + "cellSpacing", + "cellPadding", + "rowSpan", + "colSpan", + "useMap", + "frameBorder", + "contentEditable" +], function() { + jQuery.propFix[ this.toLowerCase() ] = this; +} ); + + + + + // Strip and collapse whitespace according to HTML spec + // https://infra.spec.whatwg.org/#strip-and-collapse-ascii-whitespace + function stripAndCollapse( value ) { + var tokens = value.match( rnothtmlwhite ) || []; + return tokens.join( " " ); + } + + +function getClass( elem ) { + return elem.getAttribute && elem.getAttribute( "class" ) || ""; +} + +function classesToArray( value ) { + if ( Array.isArray( value ) ) { + return value; + } + if ( typeof value === "string" ) { + return value.match( rnothtmlwhite ) || []; + } + return []; +} + +jQuery.fn.extend( { + addClass: function( value ) { + var classes, elem, cur, curValue, clazz, j, finalValue, + i = 0; + + if ( isFunction( value ) ) { + return this.each( function( j ) { + jQuery( this ).addClass( value.call( this, j, getClass( this ) ) ); + } ); + } + + classes = classesToArray( value ); + + if ( classes.length ) { + while ( ( elem = this[ i++ ] ) ) { + curValue = getClass( elem ); + cur = elem.nodeType === 1 && ( " " + stripAndCollapse( curValue ) + " " ); + + if ( cur ) { + j = 0; + while ( ( clazz = classes[ j++ ] ) ) { + if ( cur.indexOf( " " + clazz + " " ) < 0 ) { + cur += clazz + " "; + } + } + + // Only assign if different to avoid unneeded rendering. + finalValue = stripAndCollapse( cur ); + if ( curValue !== finalValue ) { + elem.setAttribute( "class", finalValue ); + } + } + } + } + + return this; + }, + + removeClass: function( value ) { + var classes, elem, cur, curValue, clazz, j, finalValue, + i = 0; + + if ( isFunction( value ) ) { + return this.each( function( j ) { + jQuery( this ).removeClass( value.call( this, j, getClass( this ) ) ); + } ); + } + + if ( !arguments.length ) { + return this.attr( "class", "" ); + } + + classes = classesToArray( value ); + + if ( classes.length ) { + while ( ( elem = this[ i++ ] ) ) { + curValue = getClass( elem ); + + // This expression is here for better compressibility (see addClass) + cur = elem.nodeType === 1 && ( " " + stripAndCollapse( curValue ) + " " ); + + if ( cur ) { + j = 0; + while ( ( clazz = classes[ j++ ] ) ) { + + // Remove *all* instances + while ( cur.indexOf( " " + clazz + " " ) > -1 ) { + cur = cur.replace( " " + clazz + " ", " " ); + } + } + + // Only assign if different to avoid unneeded rendering. + finalValue = stripAndCollapse( cur ); + if ( curValue !== finalValue ) { + elem.setAttribute( "class", finalValue ); + } + } + } + } + + return this; + }, + + toggleClass: function( value, stateVal ) { + var type = typeof value, + isValidValue = type === "string" || Array.isArray( value ); + + if ( typeof stateVal === "boolean" && isValidValue ) { + return stateVal ? this.addClass( value ) : this.removeClass( value ); + } + + if ( isFunction( value ) ) { + return this.each( function( i ) { + jQuery( this ).toggleClass( + value.call( this, i, getClass( this ), stateVal ), + stateVal + ); + } ); + } + + return this.each( function() { + var className, i, self, classNames; + + if ( isValidValue ) { + + // Toggle individual class names + i = 0; + self = jQuery( this ); + classNames = classesToArray( value ); + + while ( ( className = classNames[ i++ ] ) ) { + + // Check each className given, space separated list + if ( self.hasClass( className ) ) { + self.removeClass( className ); + } else { + self.addClass( className ); + } + } + + // Toggle whole class name + } else if ( value === undefined || type === "boolean" ) { + className = getClass( this ); + if ( className ) { + + // Store className if set + dataPriv.set( this, "__className__", className ); + } + + // If the element has a class name or if we're passed `false`, + // then remove the whole classname (if there was one, the above saved it). + // Otherwise bring back whatever was previously saved (if anything), + // falling back to the empty string if nothing was stored. + if ( this.setAttribute ) { + this.setAttribute( "class", + className || value === false ? + "" : + dataPriv.get( this, "__className__" ) || "" + ); + } + } + } ); + }, + + hasClass: function( selector ) { + var className, elem, + i = 0; + + className = " " + selector + " "; + while ( ( elem = this[ i++ ] ) ) { + if ( elem.nodeType === 1 && + ( " " + stripAndCollapse( getClass( elem ) ) + " " ).indexOf( className ) > -1 ) { + return true; + } + } + + return false; + } +} ); + + + + +var rreturn = /\r/g; + +jQuery.fn.extend( { + val: function( value ) { + var hooks, ret, valueIsFunction, + elem = this[ 0 ]; + + if ( !arguments.length ) { + if ( elem ) { + hooks = jQuery.valHooks[ elem.type ] || + jQuery.valHooks[ elem.nodeName.toLowerCase() ]; + + if ( hooks && + "get" in hooks && + ( ret = hooks.get( elem, "value" ) ) !== undefined + ) { + return ret; + } + + ret = elem.value; + + // Handle most common string cases + if ( typeof ret === "string" ) { + return ret.replace( rreturn, "" ); + } + + // Handle cases where value is null/undef or number + return ret == null ? "" : ret; + } + + return; + } + + valueIsFunction = isFunction( value ); + + return this.each( function( i ) { + var val; + + if ( this.nodeType !== 1 ) { + return; + } + + if ( valueIsFunction ) { + val = value.call( this, i, jQuery( this ).val() ); + } else { + val = value; + } + + // Treat null/undefined as ""; convert numbers to string + if ( val == null ) { + val = ""; + + } else if ( typeof val === "number" ) { + val += ""; + + } else if ( Array.isArray( val ) ) { + val = jQuery.map( val, function( value ) { + return value == null ? "" : value + ""; + } ); + } + + hooks = jQuery.valHooks[ this.type ] || jQuery.valHooks[ this.nodeName.toLowerCase() ]; + + // If set returns undefined, fall back to normal setting + if ( !hooks || !( "set" in hooks ) || hooks.set( this, val, "value" ) === undefined ) { + this.value = val; + } + } ); + } +} ); + +jQuery.extend( { + valHooks: { + option: { + get: function( elem ) { + + var val = jQuery.find.attr( elem, "value" ); + return val != null ? + val : + + // Support: IE <=10 - 11 only + // option.text throws exceptions (#14686, #14858) + // Strip and collapse whitespace + // https://html.spec.whatwg.org/#strip-and-collapse-whitespace + stripAndCollapse( jQuery.text( elem ) ); + } + }, + select: { + get: function( elem ) { + var value, option, i, + options = elem.options, + index = elem.selectedIndex, + one = elem.type === "select-one", + values = one ? null : [], + max = one ? index + 1 : options.length; + + if ( index < 0 ) { + i = max; + + } else { + i = one ? index : 0; + } + + // Loop through all the selected options + for ( ; i < max; i++ ) { + option = options[ i ]; + + // Support: IE <=9 only + // IE8-9 doesn't update selected after form reset (#2551) + if ( ( option.selected || i === index ) && + + // Don't return options that are disabled or in a disabled optgroup + !option.disabled && + ( !option.parentNode.disabled || + !nodeName( option.parentNode, "optgroup" ) ) ) { + + // Get the specific value for the option + value = jQuery( option ).val(); + + // We don't need an array for one selects + if ( one ) { + return value; + } + + // Multi-Selects return an array + values.push( value ); + } + } + + return values; + }, + + set: function( elem, value ) { + var optionSet, option, + options = elem.options, + values = jQuery.makeArray( value ), + i = options.length; + + while ( i-- ) { + option = options[ i ]; + + /* eslint-disable no-cond-assign */ + + if ( option.selected = + jQuery.inArray( jQuery.valHooks.option.get( option ), values ) > -1 + ) { + optionSet = true; + } + + /* eslint-enable no-cond-assign */ + } + + // Force browsers to behave consistently when non-matching value is set + if ( !optionSet ) { + elem.selectedIndex = -1; + } + return values; + } + } + } +} ); + +// Radios and checkboxes getter/setter +jQuery.each( [ "radio", "checkbox" ], function() { + jQuery.valHooks[ this ] = { + set: function( elem, value ) { + if ( Array.isArray( value ) ) { + return ( elem.checked = jQuery.inArray( jQuery( elem ).val(), value ) > -1 ); + } + } + }; + if ( !support.checkOn ) { + jQuery.valHooks[ this ].get = function( elem ) { + return elem.getAttribute( "value" ) === null ? "on" : elem.value; + }; + } +} ); + + + + +// Return jQuery for attributes-only inclusion + + +support.focusin = "onfocusin" in window; + + +var rfocusMorph = /^(?:focusinfocus|focusoutblur)$/, + stopPropagationCallback = function( e ) { + e.stopPropagation(); + }; + +jQuery.extend( jQuery.event, { + + trigger: function( event, data, elem, onlyHandlers ) { + + var i, cur, tmp, bubbleType, ontype, handle, special, lastElement, + eventPath = [ elem || document ], + type = hasOwn.call( event, "type" ) ? event.type : event, + namespaces = hasOwn.call( event, "namespace" ) ? event.namespace.split( "." ) : []; + + cur = lastElement = tmp = elem = elem || document; + + // Don't do events on text and comment nodes + if ( elem.nodeType === 3 || elem.nodeType === 8 ) { + return; + } + + // focus/blur morphs to focusin/out; ensure we're not firing them right now + if ( rfocusMorph.test( type + jQuery.event.triggered ) ) { + return; + } + + if ( type.indexOf( "." ) > -1 ) { + + // Namespaced trigger; create a regexp to match event type in handle() + namespaces = type.split( "." ); + type = namespaces.shift(); + namespaces.sort(); + } + ontype = type.indexOf( ":" ) < 0 && "on" + type; + + // Caller can pass in a jQuery.Event object, Object, or just an event type string + event = event[ jQuery.expando ] ? + event : + new jQuery.Event( type, typeof event === "object" && event ); + + // Trigger bitmask: & 1 for native handlers; & 2 for jQuery (always true) + event.isTrigger = onlyHandlers ? 2 : 3; + event.namespace = namespaces.join( "." ); + event.rnamespace = event.namespace ? + new RegExp( "(^|\\.)" + namespaces.join( "\\.(?:.*\\.|)" ) + "(\\.|$)" ) : + null; + + // Clean up the event in case it is being reused + event.result = undefined; + if ( !event.target ) { + event.target = elem; + } + + // Clone any incoming data and prepend the event, creating the handler arg list + data = data == null ? + [ event ] : + jQuery.makeArray( data, [ event ] ); + + // Allow special events to draw outside the lines + special = jQuery.event.special[ type ] || {}; + if ( !onlyHandlers && special.trigger && special.trigger.apply( elem, data ) === false ) { + return; + } + + // Determine event propagation path in advance, per W3C events spec (#9951) + // Bubble up to document, then to window; watch for a global ownerDocument var (#9724) + if ( !onlyHandlers && !special.noBubble && !isWindow( elem ) ) { + + bubbleType = special.delegateType || type; + if ( !rfocusMorph.test( bubbleType + type ) ) { + cur = cur.parentNode; + } + for ( ; cur; cur = cur.parentNode ) { + eventPath.push( cur ); + tmp = cur; + } + + // Only add window if we got to document (e.g., not plain obj or detached DOM) + if ( tmp === ( elem.ownerDocument || document ) ) { + eventPath.push( tmp.defaultView || tmp.parentWindow || window ); + } + } + + // Fire handlers on the event path + i = 0; + while ( ( cur = eventPath[ i++ ] ) && !event.isPropagationStopped() ) { + lastElement = cur; + event.type = i > 1 ? + bubbleType : + special.bindType || type; + + // jQuery handler + handle = ( dataPriv.get( cur, "events" ) || Object.create( null ) )[ event.type ] && + dataPriv.get( cur, "handle" ); + if ( handle ) { + handle.apply( cur, data ); + } + + // Native handler + handle = ontype && cur[ ontype ]; + if ( handle && handle.apply && acceptData( cur ) ) { + event.result = handle.apply( cur, data ); + if ( event.result === false ) { + event.preventDefault(); + } + } + } + event.type = type; + + // If nobody prevented the default action, do it now + if ( !onlyHandlers && !event.isDefaultPrevented() ) { + + if ( ( !special._default || + special._default.apply( eventPath.pop(), data ) === false ) && + acceptData( elem ) ) { + + // Call a native DOM method on the target with the same name as the event. + // Don't do default actions on window, that's where global variables be (#6170) + if ( ontype && isFunction( elem[ type ] ) && !isWindow( elem ) ) { + + // Don't re-trigger an onFOO event when we call its FOO() method + tmp = elem[ ontype ]; + + if ( tmp ) { + elem[ ontype ] = null; + } + + // Prevent re-triggering of the same event, since we already bubbled it above + jQuery.event.triggered = type; + + if ( event.isPropagationStopped() ) { + lastElement.addEventListener( type, stopPropagationCallback ); + } + + elem[ type ](); + + if ( event.isPropagationStopped() ) { + lastElement.removeEventListener( type, stopPropagationCallback ); + } + + jQuery.event.triggered = undefined; + + if ( tmp ) { + elem[ ontype ] = tmp; + } + } + } + } + + return event.result; + }, + + // Piggyback on a donor event to simulate a different one + // Used only for `focus(in | out)` events + simulate: function( type, elem, event ) { + var e = jQuery.extend( + new jQuery.Event(), + event, + { + type: type, + isSimulated: true + } + ); + + jQuery.event.trigger( e, null, elem ); + } + +} ); + +jQuery.fn.extend( { + + trigger: function( type, data ) { + return this.each( function() { + jQuery.event.trigger( type, data, this ); + } ); + }, + triggerHandler: function( type, data ) { + var elem = this[ 0 ]; + if ( elem ) { + return jQuery.event.trigger( type, data, elem, true ); + } + } +} ); + + +// Support: Firefox <=44 +// Firefox doesn't have focus(in | out) events +// Related ticket - https://bugzilla.mozilla.org/show_bug.cgi?id=687787 +// +// Support: Chrome <=48 - 49, Safari <=9.0 - 9.1 +// focus(in | out) events fire after focus & blur events, +// which is spec violation - http://www.w3.org/TR/DOM-Level-3-Events/#events-focusevent-event-order +// Related ticket - https://bugs.chromium.org/p/chromium/issues/detail?id=449857 +if ( !support.focusin ) { + jQuery.each( { focus: "focusin", blur: "focusout" }, function( orig, fix ) { + + // Attach a single capturing handler on the document while someone wants focusin/focusout + var handler = function( event ) { + jQuery.event.simulate( fix, event.target, jQuery.event.fix( event ) ); + }; + + jQuery.event.special[ fix ] = { + setup: function() { + + // Handle: regular nodes (via `this.ownerDocument`), window + // (via `this.document`) & document (via `this`). + var doc = this.ownerDocument || this.document || this, + attaches = dataPriv.access( doc, fix ); + + if ( !attaches ) { + doc.addEventListener( orig, handler, true ); + } + dataPriv.access( doc, fix, ( attaches || 0 ) + 1 ); + }, + teardown: function() { + var doc = this.ownerDocument || this.document || this, + attaches = dataPriv.access( doc, fix ) - 1; + + if ( !attaches ) { + doc.removeEventListener( orig, handler, true ); + dataPriv.remove( doc, fix ); + + } else { + dataPriv.access( doc, fix, attaches ); + } + } + }; + } ); +} +var location = window.location; + +var nonce = { guid: Date.now() }; + +var rquery = ( /\?/ ); + + + +// Cross-browser xml parsing +jQuery.parseXML = function( data ) { + var xml, parserErrorElem; + if ( !data || typeof data !== "string" ) { + return null; + } + + // Support: IE 9 - 11 only + // IE throws on parseFromString with invalid input. + try { + xml = ( new window.DOMParser() ).parseFromString( data, "text/xml" ); + } catch ( e ) {} + + parserErrorElem = xml && xml.getElementsByTagName( "parsererror" )[ 0 ]; + if ( !xml || parserErrorElem ) { + jQuery.error( "Invalid XML: " + ( + parserErrorElem ? + jQuery.map( parserErrorElem.childNodes, function( el ) { + return el.textContent; + } ).join( "\n" ) : + data + ) ); + } + return xml; +}; + + +var + rbracket = /\[\]$/, + rCRLF = /\r?\n/g, + rsubmitterTypes = /^(?:submit|button|image|reset|file)$/i, + rsubmittable = /^(?:input|select|textarea|keygen)/i; + +function buildParams( prefix, obj, traditional, add ) { + var name; + + if ( Array.isArray( obj ) ) { + + // Serialize array item. + jQuery.each( obj, function( i, v ) { + if ( traditional || rbracket.test( prefix ) ) { + + // Treat each array item as a scalar. + add( prefix, v ); + + } else { + + // Item is non-scalar (array or object), encode its numeric index. + buildParams( + prefix + "[" + ( typeof v === "object" && v != null ? i : "" ) + "]", + v, + traditional, + add + ); + } + } ); + + } else if ( !traditional && toType( obj ) === "object" ) { + + // Serialize object item. + for ( name in obj ) { + buildParams( prefix + "[" + name + "]", obj[ name ], traditional, add ); + } + + } else { + + // Serialize scalar item. + add( prefix, obj ); + } +} + +// Serialize an array of form elements or a set of +// key/values into a query string +jQuery.param = function( a, traditional ) { + var prefix, + s = [], + add = function( key, valueOrFunction ) { + + // If value is a function, invoke it and use its return value + var value = isFunction( valueOrFunction ) ? + valueOrFunction() : + valueOrFunction; + + s[ s.length ] = encodeURIComponent( key ) + "=" + + encodeURIComponent( value == null ? "" : value ); + }; + + if ( a == null ) { + return ""; + } + + // If an array was passed in, assume that it is an array of form elements. + if ( Array.isArray( a ) || ( a.jquery && !jQuery.isPlainObject( a ) ) ) { + + // Serialize the form elements + jQuery.each( a, function() { + add( this.name, this.value ); + } ); + + } else { + + // If traditional, encode the "old" way (the way 1.3.2 or older + // did it), otherwise encode params recursively. + for ( prefix in a ) { + buildParams( prefix, a[ prefix ], traditional, add ); + } + } + + // Return the resulting serialization + return s.join( "&" ); +}; + +jQuery.fn.extend( { + serialize: function() { + return jQuery.param( this.serializeArray() ); + }, + serializeArray: function() { + return this.map( function() { + + // Can add propHook for "elements" to filter or add form elements + var elements = jQuery.prop( this, "elements" ); + return elements ? jQuery.makeArray( elements ) : this; + } ).filter( function() { + var type = this.type; + + // Use .is( ":disabled" ) so that fieldset[disabled] works + return this.name && !jQuery( this ).is( ":disabled" ) && + rsubmittable.test( this.nodeName ) && !rsubmitterTypes.test( type ) && + ( this.checked || !rcheckableType.test( type ) ); + } ).map( function( _i, elem ) { + var val = jQuery( this ).val(); + + if ( val == null ) { + return null; + } + + if ( Array.isArray( val ) ) { + return jQuery.map( val, function( val ) { + return { name: elem.name, value: val.replace( rCRLF, "\r\n" ) }; + } ); + } + + return { name: elem.name, value: val.replace( rCRLF, "\r\n" ) }; + } ).get(); + } +} ); + + +var + r20 = /%20/g, + rhash = /#.*$/, + rantiCache = /([?&])_=[^&]*/, + rheaders = /^(.*?):[ \t]*([^\r\n]*)$/mg, + + // #7653, #8125, #8152: local protocol detection + rlocalProtocol = /^(?:about|app|app-storage|.+-extension|file|res|widget):$/, + rnoContent = /^(?:GET|HEAD)$/, + rprotocol = /^\/\//, + + /* Prefilters + * 1) They are useful to introduce custom dataTypes (see ajax/jsonp.js for an example) + * 2) These are called: + * - BEFORE asking for a transport + * - AFTER param serialization (s.data is a string if s.processData is true) + * 3) key is the dataType + * 4) the catchall symbol "*" can be used + * 5) execution will start with transport dataType and THEN continue down to "*" if needed + */ + prefilters = {}, + + /* Transports bindings + * 1) key is the dataType + * 2) the catchall symbol "*" can be used + * 3) selection will start with transport dataType and THEN go to "*" if needed + */ + transports = {}, + + // Avoid comment-prolog char sequence (#10098); must appease lint and evade compression + allTypes = "*/".concat( "*" ), + + // Anchor tag for parsing the document origin + originAnchor = document.createElement( "a" ); + +originAnchor.href = location.href; + +// Base "constructor" for jQuery.ajaxPrefilter and jQuery.ajaxTransport +function addToPrefiltersOrTransports( structure ) { + + // dataTypeExpression is optional and defaults to "*" + return function( dataTypeExpression, func ) { + + if ( typeof dataTypeExpression !== "string" ) { + func = dataTypeExpression; + dataTypeExpression = "*"; + } + + var dataType, + i = 0, + dataTypes = dataTypeExpression.toLowerCase().match( rnothtmlwhite ) || []; + + if ( isFunction( func ) ) { + + // For each dataType in the dataTypeExpression + while ( ( dataType = dataTypes[ i++ ] ) ) { + + // Prepend if requested + if ( dataType[ 0 ] === "+" ) { + dataType = dataType.slice( 1 ) || "*"; + ( structure[ dataType ] = structure[ dataType ] || [] ).unshift( func ); + + // Otherwise append + } else { + ( structure[ dataType ] = structure[ dataType ] || [] ).push( func ); + } + } + } + }; +} + +// Base inspection function for prefilters and transports +function inspectPrefiltersOrTransports( structure, options, originalOptions, jqXHR ) { + + var inspected = {}, + seekingTransport = ( structure === transports ); + + function inspect( dataType ) { + var selected; + inspected[ dataType ] = true; + jQuery.each( structure[ dataType ] || [], function( _, prefilterOrFactory ) { + var dataTypeOrTransport = prefilterOrFactory( options, originalOptions, jqXHR ); + if ( typeof dataTypeOrTransport === "string" && + !seekingTransport && !inspected[ dataTypeOrTransport ] ) { + + options.dataTypes.unshift( dataTypeOrTransport ); + inspect( dataTypeOrTransport ); + return false; + } else if ( seekingTransport ) { + return !( selected = dataTypeOrTransport ); + } + } ); + return selected; + } + + return inspect( options.dataTypes[ 0 ] ) || !inspected[ "*" ] && inspect( "*" ); +} + +// A special extend for ajax options +// that takes "flat" options (not to be deep extended) +// Fixes #9887 +function ajaxExtend( target, src ) { + var key, deep, + flatOptions = jQuery.ajaxSettings.flatOptions || {}; + + for ( key in src ) { + if ( src[ key ] !== undefined ) { + ( flatOptions[ key ] ? target : ( deep || ( deep = {} ) ) )[ key ] = src[ key ]; + } + } + if ( deep ) { + jQuery.extend( true, target, deep ); + } + + return target; +} + +/* Handles responses to an ajax request: + * - finds the right dataType (mediates between content-type and expected dataType) + * - returns the corresponding response + */ +function ajaxHandleResponses( s, jqXHR, responses ) { + + var ct, type, finalDataType, firstDataType, + contents = s.contents, + dataTypes = s.dataTypes; + + // Remove auto dataType and get content-type in the process + while ( dataTypes[ 0 ] === "*" ) { + dataTypes.shift(); + if ( ct === undefined ) { + ct = s.mimeType || jqXHR.getResponseHeader( "Content-Type" ); + } + } + + // Check if we're dealing with a known content-type + if ( ct ) { + for ( type in contents ) { + if ( contents[ type ] && contents[ type ].test( ct ) ) { + dataTypes.unshift( type ); + break; + } + } + } + + // Check to see if we have a response for the expected dataType + if ( dataTypes[ 0 ] in responses ) { + finalDataType = dataTypes[ 0 ]; + } else { + + // Try convertible dataTypes + for ( type in responses ) { + if ( !dataTypes[ 0 ] || s.converters[ type + " " + dataTypes[ 0 ] ] ) { + finalDataType = type; + break; + } + if ( !firstDataType ) { + firstDataType = type; + } + } + + // Or just use first one + finalDataType = finalDataType || firstDataType; + } + + // If we found a dataType + // We add the dataType to the list if needed + // and return the corresponding response + if ( finalDataType ) { + if ( finalDataType !== dataTypes[ 0 ] ) { + dataTypes.unshift( finalDataType ); + } + return responses[ finalDataType ]; + } +} + +/* Chain conversions given the request and the original response + * Also sets the responseXXX fields on the jqXHR instance + */ +function ajaxConvert( s, response, jqXHR, isSuccess ) { + var conv2, current, conv, tmp, prev, + converters = {}, + + // Work with a copy of dataTypes in case we need to modify it for conversion + dataTypes = s.dataTypes.slice(); + + // Create converters map with lowercased keys + if ( dataTypes[ 1 ] ) { + for ( conv in s.converters ) { + converters[ conv.toLowerCase() ] = s.converters[ conv ]; + } + } + + current = dataTypes.shift(); + + // Convert to each sequential dataType + while ( current ) { + + if ( s.responseFields[ current ] ) { + jqXHR[ s.responseFields[ current ] ] = response; + } + + // Apply the dataFilter if provided + if ( !prev && isSuccess && s.dataFilter ) { + response = s.dataFilter( response, s.dataType ); + } + + prev = current; + current = dataTypes.shift(); + + if ( current ) { + + // There's only work to do if current dataType is non-auto + if ( current === "*" ) { + + current = prev; + + // Convert response if prev dataType is non-auto and differs from current + } else if ( prev !== "*" && prev !== current ) { + + // Seek a direct converter + conv = converters[ prev + " " + current ] || converters[ "* " + current ]; + + // If none found, seek a pair + if ( !conv ) { + for ( conv2 in converters ) { + + // If conv2 outputs current + tmp = conv2.split( " " ); + if ( tmp[ 1 ] === current ) { + + // If prev can be converted to accepted input + conv = converters[ prev + " " + tmp[ 0 ] ] || + converters[ "* " + tmp[ 0 ] ]; + if ( conv ) { + + // Condense equivalence converters + if ( conv === true ) { + conv = converters[ conv2 ]; + + // Otherwise, insert the intermediate dataType + } else if ( converters[ conv2 ] !== true ) { + current = tmp[ 0 ]; + dataTypes.unshift( tmp[ 1 ] ); + } + break; + } + } + } + } + + // Apply converter (if not an equivalence) + if ( conv !== true ) { + + // Unless errors are allowed to bubble, catch and return them + if ( conv && s.throws ) { + response = conv( response ); + } else { + try { + response = conv( response ); + } catch ( e ) { + return { + state: "parsererror", + error: conv ? e : "No conversion from " + prev + " to " + current + }; + } + } + } + } + } + } + + return { state: "success", data: response }; +} + +jQuery.extend( { + + // Counter for holding the number of active queries + active: 0, + + // Last-Modified header cache for next request + lastModified: {}, + etag: {}, + + ajaxSettings: { + url: location.href, + type: "GET", + isLocal: rlocalProtocol.test( location.protocol ), + global: true, + processData: true, + async: true, + contentType: "application/x-www-form-urlencoded; charset=UTF-8", + + /* + timeout: 0, + data: null, + dataType: null, + username: null, + password: null, + cache: null, + throws: false, + traditional: false, + headers: {}, + */ + + accepts: { + "*": allTypes, + text: "text/plain", + html: "text/html", + xml: "application/xml, text/xml", + json: "application/json, text/javascript" + }, + + contents: { + xml: /\bxml\b/, + html: /\bhtml/, + json: /\bjson\b/ + }, + + responseFields: { + xml: "responseXML", + text: "responseText", + json: "responseJSON" + }, + + // Data converters + // Keys separate source (or catchall "*") and destination types with a single space + converters: { + + // Convert anything to text + "* text": String, + + // Text to html (true = no transformation) + "text html": true, + + // Evaluate text as a json expression + "text json": JSON.parse, + + // Parse text as xml + "text xml": jQuery.parseXML + }, + + // For options that shouldn't be deep extended: + // you can add your own custom options here if + // and when you create one that shouldn't be + // deep extended (see ajaxExtend) + flatOptions: { + url: true, + context: true + } + }, + + // Creates a full fledged settings object into target + // with both ajaxSettings and settings fields. + // If target is omitted, writes into ajaxSettings. + ajaxSetup: function( target, settings ) { + return settings ? + + // Building a settings object + ajaxExtend( ajaxExtend( target, jQuery.ajaxSettings ), settings ) : + + // Extending ajaxSettings + ajaxExtend( jQuery.ajaxSettings, target ); + }, + + ajaxPrefilter: addToPrefiltersOrTransports( prefilters ), + ajaxTransport: addToPrefiltersOrTransports( transports ), + + // Main method + ajax: function( url, options ) { + + // If url is an object, simulate pre-1.5 signature + if ( typeof url === "object" ) { + options = url; + url = undefined; + } + + // Force options to be an object + options = options || {}; + + var transport, + + // URL without anti-cache param + cacheURL, + + // Response headers + responseHeadersString, + responseHeaders, + + // timeout handle + timeoutTimer, + + // Url cleanup var + urlAnchor, + + // Request state (becomes false upon send and true upon completion) + completed, + + // To know if global events are to be dispatched + fireGlobals, + + // Loop variable + i, + + // uncached part of the url + uncached, + + // Create the final options object + s = jQuery.ajaxSetup( {}, options ), + + // Callbacks context + callbackContext = s.context || s, + + // Context for global events is callbackContext if it is a DOM node or jQuery collection + globalEventContext = s.context && + ( callbackContext.nodeType || callbackContext.jquery ) ? + jQuery( callbackContext ) : + jQuery.event, + + // Deferreds + deferred = jQuery.Deferred(), + completeDeferred = jQuery.Callbacks( "once memory" ), + + // Status-dependent callbacks + statusCode = s.statusCode || {}, + + // Headers (they are sent all at once) + requestHeaders = {}, + requestHeadersNames = {}, + + // Default abort message + strAbort = "canceled", + + // Fake xhr + jqXHR = { + readyState: 0, + + // Builds headers hashtable if needed + getResponseHeader: function( key ) { + var match; + if ( completed ) { + if ( !responseHeaders ) { + responseHeaders = {}; + while ( ( match = rheaders.exec( responseHeadersString ) ) ) { + responseHeaders[ match[ 1 ].toLowerCase() + " " ] = + ( responseHeaders[ match[ 1 ].toLowerCase() + " " ] || [] ) + .concat( match[ 2 ] ); + } + } + match = responseHeaders[ key.toLowerCase() + " " ]; + } + return match == null ? null : match.join( ", " ); + }, + + // Raw string + getAllResponseHeaders: function() { + return completed ? responseHeadersString : null; + }, + + // Caches the header + setRequestHeader: function( name, value ) { + if ( completed == null ) { + name = requestHeadersNames[ name.toLowerCase() ] = + requestHeadersNames[ name.toLowerCase() ] || name; + requestHeaders[ name ] = value; + } + return this; + }, + + // Overrides response content-type header + overrideMimeType: function( type ) { + if ( completed == null ) { + s.mimeType = type; + } + return this; + }, + + // Status-dependent callbacks + statusCode: function( map ) { + var code; + if ( map ) { + if ( completed ) { + + // Execute the appropriate callbacks + jqXHR.always( map[ jqXHR.status ] ); + } else { + + // Lazy-add the new callbacks in a way that preserves old ones + for ( code in map ) { + statusCode[ code ] = [ statusCode[ code ], map[ code ] ]; + } + } + } + return this; + }, + + // Cancel the request + abort: function( statusText ) { + var finalText = statusText || strAbort; + if ( transport ) { + transport.abort( finalText ); + } + done( 0, finalText ); + return this; + } + }; + + // Attach deferreds + deferred.promise( jqXHR ); + + // Add protocol if not provided (prefilters might expect it) + // Handle falsy url in the settings object (#10093: consistency with old signature) + // We also use the url parameter if available + s.url = ( ( url || s.url || location.href ) + "" ) + .replace( rprotocol, location.protocol + "//" ); + + // Alias method option to type as per ticket #12004 + s.type = options.method || options.type || s.method || s.type; + + // Extract dataTypes list + s.dataTypes = ( s.dataType || "*" ).toLowerCase().match( rnothtmlwhite ) || [ "" ]; + + // A cross-domain request is in order when the origin doesn't match the current origin. + if ( s.crossDomain == null ) { + urlAnchor = document.createElement( "a" ); + + // Support: IE <=8 - 11, Edge 12 - 15 + // IE throws exception on accessing the href property if url is malformed, + // e.g. http://example.com:80x/ + try { + urlAnchor.href = s.url; + + // Support: IE <=8 - 11 only + // Anchor's host property isn't correctly set when s.url is relative + urlAnchor.href = urlAnchor.href; + s.crossDomain = originAnchor.protocol + "//" + originAnchor.host !== + urlAnchor.protocol + "//" + urlAnchor.host; + } catch ( e ) { + + // If there is an error parsing the URL, assume it is crossDomain, + // it can be rejected by the transport if it is invalid + s.crossDomain = true; + } + } + + // Convert data if not already a string + if ( s.data && s.processData && typeof s.data !== "string" ) { + s.data = jQuery.param( s.data, s.traditional ); + } + + // Apply prefilters + inspectPrefiltersOrTransports( prefilters, s, options, jqXHR ); + + // If request was aborted inside a prefilter, stop there + if ( completed ) { + return jqXHR; + } + + // We can fire global events as of now if asked to + // Don't fire events if jQuery.event is undefined in an AMD-usage scenario (#15118) + fireGlobals = jQuery.event && s.global; + + // Watch for a new set of requests + if ( fireGlobals && jQuery.active++ === 0 ) { + jQuery.event.trigger( "ajaxStart" ); + } + + // Uppercase the type + s.type = s.type.toUpperCase(); + + // Determine if request has content + s.hasContent = !rnoContent.test( s.type ); + + // Save the URL in case we're toying with the If-Modified-Since + // and/or If-None-Match header later on + // Remove hash to simplify url manipulation + cacheURL = s.url.replace( rhash, "" ); + + // More options handling for requests with no content + if ( !s.hasContent ) { + + // Remember the hash so we can put it back + uncached = s.url.slice( cacheURL.length ); + + // If data is available and should be processed, append data to url + if ( s.data && ( s.processData || typeof s.data === "string" ) ) { + cacheURL += ( rquery.test( cacheURL ) ? "&" : "?" ) + s.data; + + // #9682: remove data so that it's not used in an eventual retry + delete s.data; + } + + // Add or update anti-cache param if needed + if ( s.cache === false ) { + cacheURL = cacheURL.replace( rantiCache, "$1" ); + uncached = ( rquery.test( cacheURL ) ? "&" : "?" ) + "_=" + ( nonce.guid++ ) + + uncached; + } + + // Put hash and anti-cache on the URL that will be requested (gh-1732) + s.url = cacheURL + uncached; + + // Change '%20' to '+' if this is encoded form body content (gh-2658) + } else if ( s.data && s.processData && + ( s.contentType || "" ).indexOf( "application/x-www-form-urlencoded" ) === 0 ) { + s.data = s.data.replace( r20, "+" ); + } + + // Set the If-Modified-Since and/or If-None-Match header, if in ifModified mode. + if ( s.ifModified ) { + if ( jQuery.lastModified[ cacheURL ] ) { + jqXHR.setRequestHeader( "If-Modified-Since", jQuery.lastModified[ cacheURL ] ); + } + if ( jQuery.etag[ cacheURL ] ) { + jqXHR.setRequestHeader( "If-None-Match", jQuery.etag[ cacheURL ] ); + } + } + + // Set the correct header, if data is being sent + if ( s.data && s.hasContent && s.contentType !== false || options.contentType ) { + jqXHR.setRequestHeader( "Content-Type", s.contentType ); + } + + // Set the Accepts header for the server, depending on the dataType + jqXHR.setRequestHeader( + "Accept", + s.dataTypes[ 0 ] && s.accepts[ s.dataTypes[ 0 ] ] ? + s.accepts[ s.dataTypes[ 0 ] ] + + ( s.dataTypes[ 0 ] !== "*" ? ", " + allTypes + "; q=0.01" : "" ) : + s.accepts[ "*" ] + ); + + // Check for headers option + for ( i in s.headers ) { + jqXHR.setRequestHeader( i, s.headers[ i ] ); + } + + // Allow custom headers/mimetypes and early abort + if ( s.beforeSend && + ( s.beforeSend.call( callbackContext, jqXHR, s ) === false || completed ) ) { + + // Abort if not done already and return + return jqXHR.abort(); + } + + // Aborting is no longer a cancellation + strAbort = "abort"; + + // Install callbacks on deferreds + completeDeferred.add( s.complete ); + jqXHR.done( s.success ); + jqXHR.fail( s.error ); + + // Get transport + transport = inspectPrefiltersOrTransports( transports, s, options, jqXHR ); + + // If no transport, we auto-abort + if ( !transport ) { + done( -1, "No Transport" ); + } else { + jqXHR.readyState = 1; + + // Send global event + if ( fireGlobals ) { + globalEventContext.trigger( "ajaxSend", [ jqXHR, s ] ); + } + + // If request was aborted inside ajaxSend, stop there + if ( completed ) { + return jqXHR; + } + + // Timeout + if ( s.async && s.timeout > 0 ) { + timeoutTimer = window.setTimeout( function() { + jqXHR.abort( "timeout" ); + }, s.timeout ); + } + + try { + completed = false; + transport.send( requestHeaders, done ); + } catch ( e ) { + + // Rethrow post-completion exceptions + if ( completed ) { + throw e; + } + + // Propagate others as results + done( -1, e ); + } + } + + // Callback for when everything is done + function done( status, nativeStatusText, responses, headers ) { + var isSuccess, success, error, response, modified, + statusText = nativeStatusText; + + // Ignore repeat invocations + if ( completed ) { + return; + } + + completed = true; + + // Clear timeout if it exists + if ( timeoutTimer ) { + window.clearTimeout( timeoutTimer ); + } + + // Dereference transport for early garbage collection + // (no matter how long the jqXHR object will be used) + transport = undefined; + + // Cache response headers + responseHeadersString = headers || ""; + + // Set readyState + jqXHR.readyState = status > 0 ? 4 : 0; + + // Determine if successful + isSuccess = status >= 200 && status < 300 || status === 304; + + // Get response data + if ( responses ) { + response = ajaxHandleResponses( s, jqXHR, responses ); + } + + // Use a noop converter for missing script but not if jsonp + if ( !isSuccess && + jQuery.inArray( "script", s.dataTypes ) > -1 && + jQuery.inArray( "json", s.dataTypes ) < 0 ) { + s.converters[ "text script" ] = function() {}; + } + + // Convert no matter what (that way responseXXX fields are always set) + response = ajaxConvert( s, response, jqXHR, isSuccess ); + + // If successful, handle type chaining + if ( isSuccess ) { + + // Set the If-Modified-Since and/or If-None-Match header, if in ifModified mode. + if ( s.ifModified ) { + modified = jqXHR.getResponseHeader( "Last-Modified" ); + if ( modified ) { + jQuery.lastModified[ cacheURL ] = modified; + } + modified = jqXHR.getResponseHeader( "etag" ); + if ( modified ) { + jQuery.etag[ cacheURL ] = modified; + } + } + + // if no content + if ( status === 204 || s.type === "HEAD" ) { + statusText = "nocontent"; + + // if not modified + } else if ( status === 304 ) { + statusText = "notmodified"; + + // If we have data, let's convert it + } else { + statusText = response.state; + success = response.data; + error = response.error; + isSuccess = !error; + } + } else { + + // Extract error from statusText and normalize for non-aborts + error = statusText; + if ( status || !statusText ) { + statusText = "error"; + if ( status < 0 ) { + status = 0; + } + } + } + + // Set data for the fake xhr object + jqXHR.status = status; + jqXHR.statusText = ( nativeStatusText || statusText ) + ""; + + // Success/Error + if ( isSuccess ) { + deferred.resolveWith( callbackContext, [ success, statusText, jqXHR ] ); + } else { + deferred.rejectWith( callbackContext, [ jqXHR, statusText, error ] ); + } + + // Status-dependent callbacks + jqXHR.statusCode( statusCode ); + statusCode = undefined; + + if ( fireGlobals ) { + globalEventContext.trigger( isSuccess ? "ajaxSuccess" : "ajaxError", + [ jqXHR, s, isSuccess ? success : error ] ); + } + + // Complete + completeDeferred.fireWith( callbackContext, [ jqXHR, statusText ] ); + + if ( fireGlobals ) { + globalEventContext.trigger( "ajaxComplete", [ jqXHR, s ] ); + + // Handle the global AJAX counter + if ( !( --jQuery.active ) ) { + jQuery.event.trigger( "ajaxStop" ); + } + } + } + + return jqXHR; + }, + + getJSON: function( url, data, callback ) { + return jQuery.get( url, data, callback, "json" ); + }, + + getScript: function( url, callback ) { + return jQuery.get( url, undefined, callback, "script" ); + } +} ); + +jQuery.each( [ "get", "post" ], function( _i, method ) { + jQuery[ method ] = function( url, data, callback, type ) { + + // Shift arguments if data argument was omitted + if ( isFunction( data ) ) { + type = type || callback; + callback = data; + data = undefined; + } + + // The url can be an options object (which then must have .url) + return jQuery.ajax( jQuery.extend( { + url: url, + type: method, + dataType: type, + data: data, + success: callback + }, jQuery.isPlainObject( url ) && url ) ); + }; +} ); + +jQuery.ajaxPrefilter( function( s ) { + var i; + for ( i in s.headers ) { + if ( i.toLowerCase() === "content-type" ) { + s.contentType = s.headers[ i ] || ""; + } + } +} ); + + +jQuery._evalUrl = function( url, options, doc ) { + return jQuery.ajax( { + url: url, + + // Make this explicit, since user can override this through ajaxSetup (#11264) + type: "GET", + dataType: "script", + cache: true, + async: false, + global: false, + + // Only evaluate the response if it is successful (gh-4126) + // dataFilter is not invoked for failure responses, so using it instead + // of the default converter is kludgy but it works. + converters: { + "text script": function() {} + }, + dataFilter: function( response ) { + jQuery.globalEval( response, options, doc ); + } + } ); +}; + + +jQuery.fn.extend( { + wrapAll: function( html ) { + var wrap; + + if ( this[ 0 ] ) { + if ( isFunction( html ) ) { + html = html.call( this[ 0 ] ); + } + + // The elements to wrap the target around + wrap = jQuery( html, this[ 0 ].ownerDocument ).eq( 0 ).clone( true ); + + if ( this[ 0 ].parentNode ) { + wrap.insertBefore( this[ 0 ] ); + } + + wrap.map( function() { + var elem = this; + + while ( elem.firstElementChild ) { + elem = elem.firstElementChild; + } + + return elem; + } ).append( this ); + } + + return this; + }, + + wrapInner: function( html ) { + if ( isFunction( html ) ) { + return this.each( function( i ) { + jQuery( this ).wrapInner( html.call( this, i ) ); + } ); + } + + return this.each( function() { + var self = jQuery( this ), + contents = self.contents(); + + if ( contents.length ) { + contents.wrapAll( html ); + + } else { + self.append( html ); + } + } ); + }, + + wrap: function( html ) { + var htmlIsFunction = isFunction( html ); + + return this.each( function( i ) { + jQuery( this ).wrapAll( htmlIsFunction ? html.call( this, i ) : html ); + } ); + }, + + unwrap: function( selector ) { + this.parent( selector ).not( "body" ).each( function() { + jQuery( this ).replaceWith( this.childNodes ); + } ); + return this; + } +} ); + + +jQuery.expr.pseudos.hidden = function( elem ) { + return !jQuery.expr.pseudos.visible( elem ); +}; +jQuery.expr.pseudos.visible = function( elem ) { + return !!( elem.offsetWidth || elem.offsetHeight || elem.getClientRects().length ); +}; + + + + +jQuery.ajaxSettings.xhr = function() { + try { + return new window.XMLHttpRequest(); + } catch ( e ) {} +}; + +var xhrSuccessStatus = { + + // File protocol always yields status code 0, assume 200 + 0: 200, + + // Support: IE <=9 only + // #1450: sometimes IE returns 1223 when it should be 204 + 1223: 204 + }, + xhrSupported = jQuery.ajaxSettings.xhr(); + +support.cors = !!xhrSupported && ( "withCredentials" in xhrSupported ); +support.ajax = xhrSupported = !!xhrSupported; + +jQuery.ajaxTransport( function( options ) { + var callback, errorCallback; + + // Cross domain only allowed if supported through XMLHttpRequest + if ( support.cors || xhrSupported && !options.crossDomain ) { + return { + send: function( headers, complete ) { + var i, + xhr = options.xhr(); + + xhr.open( + options.type, + options.url, + options.async, + options.username, + options.password + ); + + // Apply custom fields if provided + if ( options.xhrFields ) { + for ( i in options.xhrFields ) { + xhr[ i ] = options.xhrFields[ i ]; + } + } + + // Override mime type if needed + if ( options.mimeType && xhr.overrideMimeType ) { + xhr.overrideMimeType( options.mimeType ); + } + + // X-Requested-With header + // For cross-domain requests, seeing as conditions for a preflight are + // akin to a jigsaw puzzle, we simply never set it to be sure. + // (it can always be set on a per-request basis or even using ajaxSetup) + // For same-domain requests, won't change header if already provided. + if ( !options.crossDomain && !headers[ "X-Requested-With" ] ) { + headers[ "X-Requested-With" ] = "XMLHttpRequest"; + } + + // Set headers + for ( i in headers ) { + xhr.setRequestHeader( i, headers[ i ] ); + } + + // Callback + callback = function( type ) { + return function() { + if ( callback ) { + callback = errorCallback = xhr.onload = + xhr.onerror = xhr.onabort = xhr.ontimeout = + xhr.onreadystatechange = null; + + if ( type === "abort" ) { + xhr.abort(); + } else if ( type === "error" ) { + + // Support: IE <=9 only + // On a manual native abort, IE9 throws + // errors on any property access that is not readyState + if ( typeof xhr.status !== "number" ) { + complete( 0, "error" ); + } else { + complete( + + // File: protocol always yields status 0; see #8605, #14207 + xhr.status, + xhr.statusText + ); + } + } else { + complete( + xhrSuccessStatus[ xhr.status ] || xhr.status, + xhr.statusText, + + // Support: IE <=9 only + // IE9 has no XHR2 but throws on binary (trac-11426) + // For XHR2 non-text, let the caller handle it (gh-2498) + ( xhr.responseType || "text" ) !== "text" || + typeof xhr.responseText !== "string" ? + { binary: xhr.response } : + { text: xhr.responseText }, + xhr.getAllResponseHeaders() + ); + } + } + }; + }; + + // Listen to events + xhr.onload = callback(); + errorCallback = xhr.onerror = xhr.ontimeout = callback( "error" ); + + // Support: IE 9 only + // Use onreadystatechange to replace onabort + // to handle uncaught aborts + if ( xhr.onabort !== undefined ) { + xhr.onabort = errorCallback; + } else { + xhr.onreadystatechange = function() { + + // Check readyState before timeout as it changes + if ( xhr.readyState === 4 ) { + + // Allow onerror to be called first, + // but that will not handle a native abort + // Also, save errorCallback to a variable + // as xhr.onerror cannot be accessed + window.setTimeout( function() { + if ( callback ) { + errorCallback(); + } + } ); + } + }; + } + + // Create the abort callback + callback = callback( "abort" ); + + try { + + // Do send the request (this may raise an exception) + xhr.send( options.hasContent && options.data || null ); + } catch ( e ) { + + // #14683: Only rethrow if this hasn't been notified as an error yet + if ( callback ) { + throw e; + } + } + }, + + abort: function() { + if ( callback ) { + callback(); + } + } + }; + } +} ); + + + + +// Prevent auto-execution of scripts when no explicit dataType was provided (See gh-2432) +jQuery.ajaxPrefilter( function( s ) { + if ( s.crossDomain ) { + s.contents.script = false; + } +} ); + +// Install script dataType +jQuery.ajaxSetup( { + accepts: { + script: "text/javascript, application/javascript, " + + "application/ecmascript, application/x-ecmascript" + }, + contents: { + script: /\b(?:java|ecma)script\b/ + }, + converters: { + "text script": function( text ) { + jQuery.globalEval( text ); + return text; + } + } +} ); + +// Handle cache's special case and crossDomain +jQuery.ajaxPrefilter( "script", function( s ) { + if ( s.cache === undefined ) { + s.cache = false; + } + if ( s.crossDomain ) { + s.type = "GET"; + } +} ); + +// Bind script tag hack transport +jQuery.ajaxTransport( "script", function( s ) { + + // This transport only deals with cross domain or forced-by-attrs requests + if ( s.crossDomain || s.scriptAttrs ) { + var script, callback; + return { + send: function( _, complete ) { + script = jQuery( " - - - - - - - - + + + + + + + + + + + + + - - - -
    -
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    -

    dbparser -

    -

    CRAN_Status_Badge codecov Project Status: Active – The project has reached a stable, usable state and is being actively developed. Lifecycle: stable metacran downloads CII Best Practices

    +
    +
    +
    +
    +
    +

    dbparser +

    +
    +

    CRAN_Status_Badge codecov Project Status: Active – The project has reached a stable, usable state and is being actively developed. Lifecycle: stable metacran downloads Rdoc Documentation CII Best Practices rOpenSci Peer-Reviewed

    Overview

    -

    Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only two databases together such as DrugBank and KEGG.

    -

    Hence, dbparser package aims to parse different public drugs databases as DrugBank or KEGG into single and unified format R object called dvobject (stands for drugverse object).

    +

    Drugs databases vary too much in their formats and structures which making related data analysis not a very easy job and requires a lot of efforts to work on only two databases together such as DrugBank, OnSIDES, and TWOSIDES.

    +

    Hence, dbparser package aims to parse different public drugs databases into a single and unified format R object called dvobject (stands for drugverse object).

    +

    With recent updates, dbparser has evolved into an integration engine, allowing you to merge mechanistic data (DrugBank) with real-world phenotypic data (OnSIDES) and drug-drug interaction risks (TWOSIDES).

    That should help in:

    • working with single data object and not multiple databases in different formats,
    • using R analysis capabilities easily on drugs data,
      • -
    • ease of transferring data between researchers after performing required data analysis or dvobject and storing results in the same object in a very easy manner
      • +
    • ease of transferring data between researchers after performing required data analysis or dvobject and storing results in the same object in a very easy manner.

    dvobject Structure

    -

    dvobject introduces a unified and compressed format of drugs data. It is an R list object that contains one or more of the following sub-lists:

    +

    dvobject introduces a unified and compressed format of drugs data. It is an R list object.

    +

    For a single database (e.g., DrugBank): It contains one or more of the following sub-lists:

    • drugs: list of data.frames that contain drugs information (i.e. synonyms, classifications, …) and it is the only mandatory list
      • @@ -113,6 +95,19 @@

      dvobject Structure @@ -120,47 +115,81 @@

      Drug Databases

      Parsers are available for the following databases (it is in progress list)

      -

      DrugBank +

      1. DrugBank

      DrugBank database is a comprehensive, freely accessible, online database containing information on drugs and drug targets. As both a bioinformatics and a cheminformatics resource, DrugBank combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. More information about DrugBank can be found here.

      In its raw form, the DrugBank database is a single XML file. Users must create an account with DrugBank and request permission to download the database. Note that this may take a couple of days.

      -

      The dbparser package parses the DrugBank XML database into R tibbles that can be explored and analyzed by the user, check this tutorial for more details.

      -

      If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the dbdataset package, which contains the DrugBank database already parsed into dvobject. Note that this is a large package that exceeds the limit set by CRAN. It is only available on GitHub.

      +

      The dbparser package parses the DrugBank XML database into R tibbles that can be explored and analyzed by the user, check this tutorial for more details.

      +

      If you are waiting for access to the DrugBank database, or do not intend to do a deep dive with the data, you may wish to use the dbdataset package, which contains the DrugBank database already parsed into dvobject. Note that this is a large package that exceeds the limit set by CRAN. It is only available on GitHub.

      dbparser is tested against DrugBank versions 5.1.0 through 5.1.12 successfully. If you find errors with these versions or any other version please submit an issue here.

      +
      +

      2. OnSIDES (The Phenotype) +

      +

      OnSIDES provides adverse drug events extracted from thousands of FDA drug labels using machine learning. * Parser: parseOnSIDES() * Input: Directory containing OnSIDES CSV files.

      +
      +
      +

      3. TWOSIDES (Polypharmacy) +

      +

      TWOSIDES provides data on drug-drug interactions and the adverse events that arise when two drugs are taken together. * Parser: parseTWOSIDES() * Input: The TWOSIDES.csv.gz file.

      +
      +

    +
    +

    Quick Start: Integration Pipeline +

    +

    The power of dbparser lies in its ability to chain parsers and mergers together. Here is how you can build a complete pharmacovigilance dataset:

    +
    +library(dbparser)
+library(dplyr)
+
+# 1. Parse the raw databases
+drugbank_db <- parseDrugBank("data/drugbank.xml")
+onsides_db  <- parseOnSIDES("data/onsides/")
+twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz")
+
+# 2. Build the Integrated Knowledge Graph
+#    DrugBank serves as the hub. We chain the merges.
+final_db <- drugbank_db %>% 
+  merge_drugbank_onsides(onsides_db) %>% 
+  merge_drugbank_twosides(twosides_db)
+
+# 3. Analyze Results
+#    Example: Accessing the enriched drug-drug interaction table
+head(final_db$integrated_data$drug_drug_interactions)
    +

    For a detailed case study, please refer to the Integrated Pharmacovigilance Vignette.

    Installation

    You can install the released version of dbparser from CRAN with:

    -
    +
     install.packages("dbparser")
    
 
    or you can install the latest updates directly from the repo
    
-
    +
     library(devtools)
 devtools::install_github("ropensci/dbparser")
    
 
    
 
    
 
    Code of Conduct
 
    
-
    Please note that the ‘dbparser’ project is released with a Contributor Code of Conduct. By contributing to this project, you agree to abide by its terms.
    
+
    Please note that the ‘dbparser’ project is released with a Contributor Code of Conduct. By contributing to this project, you agree to abide by its terms.
    
 
    
 
    
 
    Contributing Guide
 
    
-
    👍🎉 First off, thanks for taking the time to contribute! 🎉👍 Please review our Contributing Guide.
    
+
    👍🎉 First off, thanks for taking the time to contribute! 🎉👍 Please review our Contributing Guide.
    
 
    
 
    
-
    Share the love ❤️
+
    Share the love ❤️
 
    
 
    Think dbparser is useful? Let others discover it, by telling them in person, via Twitter or a blog post.
    
 
    Using dbparser for a paper you are writing? Consider citing it
    
-
    +
     citation("dbparser")
 #> To cite dbparser in publications use:
 #> 
 #>   Mohammed Ali, Ali Ezzat ().  dbparser: DrugBank Database XML Parser.
-#>   R package version 2.0.3.
+#>   R package version 2.2.0.
 #> 
 #> A BibTeX entry for LaTeX users is
 #> 
@@ -168,15 +197,12 @@ 
    Share the love ❤️#>     title = {DrugBank Database XML Parser},
 #>     author = {Mohammed Ali and Ali Ezzat},
 #>     organization = {Interstellar for Consultinc inc.},
-#>     note = {R package version 2.0.3},
+#>     note = {R package version 2.2.0},
 #>     url = {https://CRAN.R-project.org/package=dbparser},
 #>   }
    
 
    
 
    
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    - -
    +
    -
    - - + diff --git a/docs/index.md b/docs/index.md new file mode 100644 index 00000000..668557ae --- /dev/null +++ b/docs/index.md @@ -0,0 +1,209 @@ +# dbparser + +[![CRAN_Status_Badge](http://www.r-pkg.org/badges/version/dbparser)](https://cran.r-project.org/package=dbparser) +[![codecov](https://codecov.io/gh/ropensci/dbparser/branch/master/graph/badge.svg)](https://app.codecov.io/gh/ropensci/dbparser) +[![Project Status: Active – The project has reached a stable, usable +state and is being actively +developed.](https://www.repostatus.org/badges/latest/active.svg)](https://www.repostatus.org/#active) +[![Lifecycle: +stable](https://img.shields.io/badge/lifecycle-stable-brightgreen.svg)](https://lifecycle.r-lib.org/articles/stages.html) +[![metacran +downloads](https://cranlogs.r-pkg.org/badges/grand-total/dbparser)](https://cran.r-project.org/package=dbparser) +[![Rdoc +Documentation](https://img.shields.io/badge/Doc-Rdoc-blue.svg)](https://www.rdocumentation.org/packages/dbparser) +[![CII Best +Practices](https://bestpractices.coreinfrastructure.org/projects/3311/badge)](https://bestpractices.coreinfrastructure.org/projects/3311) +[![rOpenSci +Peer-Reviewed](https://badges.ropensci.org/347_status.svg)](https://github.com/ropensci/software-review/issues/347) + +## Overview + +Drugs databases vary too much in their formats and structures which +making related data analysis not a very easy job and requires a lot of +efforts to work on only two databases together such as +[DrugBank](https://go.drugbank.com/), [OnSIDES](https://onsidesdb.org/), +and [TWOSIDES](https://tatonettilab.org/resources/nsides/). + +Hence, `dbparser` package aims to parse different public drugs databases +into a single and unified format R object called `dvobject` (stands for +drugverse object). + +With recent updates, `dbparser` has evolved into an **integration +engine**, allowing you to merge mechanistic data (DrugBank) with +real-world phenotypic data (OnSIDES) and drug-drug interaction risks +(TWOSIDES). + +That should help in: + +- working with single data object and not multiple databases in + different formats, +- using R analysis capabilities easily on drugs data, +- ease of transferring data between researchers after performing + required data analysis or `dvobject` and storing results in the same + object in a very easy manner. + +### dvobject Structure + +`dvobject` introduces a unified and compressed format of drugs data. It +is an R list object. + +**For a single database (e.g., DrugBank):** It contains one or more of +the following sub-lists: + +- **drugs**: list of data.frames that contain drugs information + (i.e. synonyms, classifications, …) and it is the only mandatory list +- **salts**: data.frame contains drugs salts information +- **products**: data.frame of commercially available drugs products in + the world +- **references**: data.frame of articles, links and textbooks about + drugs or CETT data +- **cett**: list of data.frames contain targets, enzymes, carriers and + transporters information + +**For a merged database (Integrated Pharmacovigilance):** When databases +are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, +the `dvobject` becomes a nested structure containing: + +- **drugbank**: The mechanistic hub. +- **onsides**: The side-effect data (from FDA labels). +- **twosides**: The drug-drug interaction data. +- **integrated_data**: Enriched tables that bridge the databases (e.g., + linking DrugBank IDs to OnSIDES adverse events). +- **metadata**: Detailed provenance for all contained datasets. + +## Drug Databases + +Parsers are available for the following databases (it is in progress +list) + +### 1. DrugBank + +[DrugBank](https://go.drugbank.com/) database is a comprehensive, freely +accessible, online database containing information on drugs and drug +targets. As both a bioinformatics and a cheminformatics resource, +DrugBank combines detailed drug (i.e. chemical, pharmacological and +pharmaceutical) data with comprehensive drug target (i.e. sequence, +structure, and pathway) information. More information about DrugBank can +be found [here](https://go.drugbank.com/about). + +In its raw form, the DrugBank database is a single XML file. Users must +create an [account](https://go.drugbank.com/public_users/sign_up) with +DrugBank and request permission to +[download](https://go.drugbank.com/releases/latest) the database. Note +that this may take a couple of days. + +The `dbparser` package parses the DrugBank XML database into `R` tibbles +that can be explored and analyzed by the user, check [this +tutorial](https://docs.ropensci.org/dbparser/articles/dbparser.html) for +more details. + +If you are waiting for access to the DrugBank database, or do not intend +to do a deep dive with the data, you may wish to use the `dbdataset` +[package](https://interstellar-egypt.github.io/dbdataset/), which +contains the DrugBank database already parsed into `dvobject`. Note that +this is a large package that exceeds the limit set by CRAN. It is only +available on GitHub. + +`dbparser` is tested against DrugBank versions *5.1.0* through *5.1.12* +successfully. If you find errors with these versions or any other +version please submit an issue +[here](https://github.com/ropensci/dbparser/issues). + +### 2. OnSIDES (The Phenotype) + +[OnSIDES](https://onsidesdb.org/) provides adverse drug events extracted +from thousands of FDA drug labels using machine learning. \* **Parser:** +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md) +\* **Input:** Directory containing OnSIDES CSV files. + +### 3. TWOSIDES (Polypharmacy) + +[TWOSIDES](https://tatonettilab.org/resources/nsides/) provides data on +drug-drug interactions and the adverse events that arise when two drugs +are taken together. \* **Parser:** +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) +\* **Input:** The `TWOSIDES.csv.gz` file. + +## Quick Start: Integration Pipeline + +The power of `dbparser` lies in its ability to chain parsers and mergers +together. Here is how you can build a complete pharmacovigilance +dataset: + +``` r +library(dbparser) +library(dplyr) + +# 1. Parse the raw databases +drugbank_db <- parseDrugBank("data/drugbank.xml") +onsides_db <- parseOnSIDES("data/onsides/") +twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz") + +# 2. Build the Integrated Knowledge Graph +# DrugBank serves as the hub. We chain the merges. +final_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# 3. Analyze Results +# Example: Accessing the enriched drug-drug interaction table +head(final_db$integrated_data$drug_drug_interactions) +``` + +For a detailed case study, please refer to the [Integrated +Pharmacovigilance +Vignette](https://docs.ropensci.org/dbparser/articles/drugbank_nside.html). + +## Installation + +You can install the released version of dbparser from +[CRAN](https://CRAN.R-project.org) with: + +``` r +install.packages("dbparser") +``` + +or you can install the latest updates directly from the repo + +``` r +library(devtools) +devtools::install_github("ropensci/dbparser") +``` + +## Code of Conduct + +Please note that the ‘dbparser’ project is released with a [Contributor +Code of +Conduct](https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html). By +contributing to this project, you agree to abide by its terms. + +## Contributing Guide + +👍🎉 First off, thanks for taking the time to contribute! 🎉👍 Please +review our [Contributing +Guide](https://docs.ropensci.org/dbparser/CONTRIBUTING.html). + +## Share the love ❤️ + +Think **dbparser** is useful? Let others discover it, by telling them in +person, via Twitter or a blog post. + +Using **dbparser** for a paper you are writing? Consider citing it + +``` r +citation("dbparser") +#> To cite dbparser in publications use: +#> +#> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. +#> R package version 2.2.0. +#> +#> A BibTeX entry for LaTeX users is +#> +#> @Manual{, +#> title = {DrugBank Database XML Parser}, +#> author = {Mohammed Ali and Ali Ezzat}, +#> organization = {Interstellar for Consultinc inc.}, +#> note = {R package version 2.2.0}, +#> url = {https://CRAN.R-project.org/package=dbparser}, +#> } +``` diff --git a/docs/katex-auto.js b/docs/katex-auto.js new file mode 100644 index 00000000..2adab3a9 --- /dev/null +++ b/docs/katex-auto.js @@ -0,0 +1,16 @@ +// https://github.com/jgm/pandoc/blob/29fa97ab96b8e2d62d48326e1b949a71dc41f47a/src/Text/Pandoc/Writers/HTML.hs#L332-L345 +document.addEventListener("DOMContentLoaded", function () { + var mathElements = document.getElementsByClassName("math"); + var macros = []; + for (var i = 0; i < mathElements.length; i++) { + var texText = mathElements[i].firstChild; + if (mathElements[i].tagName == "SPAN") { + katex.render(texText.data, mathElements[i], { + displayMode: mathElements[i].classList.contains("display"), + throwOnError: false, + macros: macros, + fleqn: false + }); + } + } +}); diff --git a/docs/lightswitch.js b/docs/lightswitch.js new file mode 100644 index 00000000..3808ca11 --- /dev/null +++ b/docs/lightswitch.js @@ -0,0 +1,85 @@ + +/*! + * Color mode toggler for Bootstrap's docs (https://getbootstrap.com/) + * Copyright 2011-2023 The Bootstrap Authors + * Licensed under the Creative Commons Attribution 3.0 Unported License. + * Updates for {pkgdown} by the {bslib} authors, also licensed under CC-BY-3.0. + */ + +const getStoredTheme = () => localStorage.getItem('theme') +const setStoredTheme = theme => localStorage.setItem('theme', theme) + +const getPreferredTheme = () => { + const storedTheme = getStoredTheme() + if (storedTheme) { + return storedTheme + } + + return window.matchMedia('(prefers-color-scheme: dark)').matches ? 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It +is an R list object. + +**For a single database (e.g., DrugBank):** It contains one or more of +the following sub-lists: + +- **drugs**: list of data.frames that contain drugs information + (i.e. synonyms, classifications, …) and it is the only mandatory list +- **salts**: data.frame contains drugs salts information +- **products**: data.frame of commercially available drugs products in + the world +- **references**: data.frame of articles, links and textbooks about + drugs or CETT data +- **cett**: list of data.frames contain targets, enzymes, carriers and + transporters information + +**For a merged database (Integrated Pharmacovigilance):** When databases +are merged using `merge_drugbank_onsides` or `merge_drugbank_twosides`, +the `dvobject` becomes a nested structure containing: + +- **drugbank**: The mechanistic hub. +- **onsides**: The side-effect data (from FDA labels). +- **twosides**: The drug-drug interaction data. +- **integrated_data**: Enriched tables that bridge the databases (e.g., + linking DrugBank IDs to OnSIDES adverse events). +- **metadata**: Detailed provenance for all contained datasets. + +## Drug Databases + +Parsers are available for the following databases (it is in progress +list) + +### 1. DrugBank + +[DrugBank](https://go.drugbank.com/) database is a comprehensive, freely +accessible, online database containing information on drugs and drug +targets. As both a bioinformatics and a cheminformatics resource, +DrugBank combines detailed drug (i.e. chemical, pharmacological and +pharmaceutical) data with comprehensive drug target (i.e. sequence, +structure, and pathway) information. More information about DrugBank can +be found [here](https://go.drugbank.com/about). + +In its raw form, the DrugBank database is a single XML file. Users must +create an [account](https://go.drugbank.com/public_users/sign_up) with +DrugBank and request permission to +[download](https://go.drugbank.com/releases/latest) the database. Note +that this may take a couple of days. + +The `dbparser` package parses the DrugBank XML database into `R` tibbles +that can be explored and analyzed by the user, check [this +tutorial](https://docs.ropensci.org/dbparser/articles/dbparser.html) for +more details. + +If you are waiting for access to the DrugBank database, or do not intend +to do a deep dive with the data, you may wish to use the `dbdataset` +[package](https://interstellar-egypt.github.io/dbdataset/), which +contains the DrugBank database already parsed into `dvobject`. Note that +this is a large package that exceeds the limit set by CRAN. It is only +available on GitHub. + +`dbparser` is tested against DrugBank versions *5.1.0* through *5.1.12* +successfully. If you find errors with these versions or any other +version please submit an issue +[here](https://github.com/ropensci/dbparser/issues). + +### 2. OnSIDES (The Phenotype) + +[OnSIDES](https://onsidesdb.org/) provides adverse drug events extracted +from thousands of FDA drug labels using machine learning. \* **Parser:** +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md) +\* **Input:** Directory containing OnSIDES CSV files. + +### 3. TWOSIDES (Polypharmacy) + +[TWOSIDES](https://tatonettilab.org/resources/nsides/) provides data on +drug-drug interactions and the adverse events that arise when two drugs +are taken together. \* **Parser:** +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) +\* **Input:** The `TWOSIDES.csv.gz` file. + +## Quick Start: Integration Pipeline + +The power of `dbparser` lies in its ability to chain parsers and mergers +together. Here is how you can build a complete pharmacovigilance +dataset: + +``` r +library(dbparser) +library(dplyr) + +# 1. Parse the raw databases +drugbank_db <- parseDrugBank("data/drugbank.xml") +onsides_db <- parseOnSIDES("data/onsides/") +twosides_db <- parseTWOSIDES("data/TWOSIDES.csv.gz") + +# 2. Build the Integrated Knowledge Graph +# DrugBank serves as the hub. We chain the merges. +final_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# 3. Analyze Results +# Example: Accessing the enriched drug-drug interaction table +head(final_db$integrated_data$drug_drug_interactions) +``` + +For a detailed case study, please refer to the [Integrated +Pharmacovigilance +Vignette](https://docs.ropensci.org/dbparser/articles/drugbank_nside.html). + +## Installation + +You can install the released version of dbparser from +[CRAN](https://CRAN.R-project.org) with: + +``` r +install.packages("dbparser") +``` + +or you can install the latest updates directly from the repo + +``` r +library(devtools) +devtools::install_github("ropensci/dbparser") +``` + +## Code of Conduct + +Please note that the ‘dbparser’ project is released with a [Contributor +Code of +Conduct](https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html). By +contributing to this project, you agree to abide by its terms. + +## Contributing Guide + +👍🎉 First off, thanks for taking the time to contribute! 🎉👍 Please +review our [Contributing +Guide](https://docs.ropensci.org/dbparser/CONTRIBUTING.html). + +## Share the love ❤️ + +Think **dbparser** is useful? Let others discover it, by telling them in +person, via Twitter or a blog post. + +Using **dbparser** for a paper you are writing? Consider citing it + +``` r +citation("dbparser") +#> To cite dbparser in publications use: +#> +#> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. +#> R package version 2.2.0. +#> +#> A BibTeX entry for LaTeX users is +#> +#> @Manual{, +#> title = {DrugBank Database XML Parser}, +#> author = {Mohammed Ali and Ali Ezzat}, +#> organization = {Interstellar for Consultinc inc.}, +#> note = {R package version 2.2.0}, +#> url = {https://CRAN.R-project.org/package=dbparser}, +#> } +``` + +# Package index + +## Drugs Databases Parser + +Parse public drug databases and converted them into dvobject + +- [`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md) + : returns carriers, enzymes,targets and transporters node valid + options. +- [`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md) + : returns drug node valid options. +- [`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md) + : parseDrugBank +- [`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md) + : Parse the OnSIDES Core Relational Database +- [`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) + : Parse the TWOSIDES Drug-Drug Interaction Database +- [`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) + : returns references node valid options. + +## Utility functions + +Different functions to handle dvobject + +- [`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md) + : add_database_info Assign passed databases db metadata to passed + dvobject +- [`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md) + : Display dvobject Metadata +- [`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md) + : Subset a DrugBank dvobject by a vector of DrugBank IDs +- [`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) + : Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs + (Schema-Aware) + +## Merge functions + +Different functions to merge different types of dvobjects + +- [`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md) + : Merge DrugBank and OnSIDES Database Objects +- [`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md) + : Merge a DrugBank dvobject with a TWOSIDES dvobject + +# Articles + +### All vignettes + +- [Unlocking DrugBank: Parsing and Visualizing Mechanistic + Data](https://docs.ropensci.org/dbparser/articles/dbparser.md): +- [Introducing dbparser + 2.2.0](https://docs.ropensci.org/dbparser/articles/dbparser_2_2.md): +- [Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and + TWOSIDES](https://docs.ropensci.org/dbparser/articles/drugbank_nside.md): diff --git a/docs/news/index.html b/docs/news/index.html index 48419291..b4727c78 100644 --- a/docs/news/index.html +++ b/docs/news/index.html @@ -1,63 +1,104 @@ -Changelog • dbparser - +Changelog • dbparser + Skip to contents -
    -
    +
    -
    -
    -

    Changelog

    + 2.2.1 + + + + + + + +
    +
    +
    +
    +

    Changelog

    Source: NEWS.md
    -

    dbparser 2.0.3

    +

    dbparser 2.2.1

    +

    This is a major feature release focused on expanding dbparser’s capabilities into real-world pharmacovigilance and drug-drug interaction analysis. The integration engine has been formalized around a “Hub and Spoke” model, with DrugBank acting as the central hub.

    +
    +

    NEW FEATURES

    +
    • +New Parser: parseOnSIDES() +
      • Parses the relational CSV files from the OnSIDES database, a modern resource for adverse drug events extracted from FDA labels.
        • +
      • Returns a dvobject containing the 7 core relational tables and an optional high_confidence summary table.
        • +
      • +
    • +New Parser: parseTWOSIDES() +
      • Parses the TWOSIDES database, the leading resource for drug-drug interaction (DDI) adverse event signals from real-world data.
        • +
      • Returns a dvobject containing the drug_drug_interactions table.
        • +
      • The parser correctly handles known column name misspellings in the source data (e.g., drug_1_rxnorn_id).
        • +
      • +
    • +New Integration Function: merge_drugbank_onsides() +
      • Merges a DrugBank dvobject with an OnSIDES dvobject.
        • +
      • Automatically creates an enriched integrated_data list, linking OnSIDES data to DrugBank IDs via RxNorm CUIs.
        • +
      • The function is chainable, meaning it can be used in a %>% pipeline after other merge functions.
        • +
      • +
    • +New Integration Function: merge_drugbank_twosides() +
      • Merges a DrugBank dvobject with a TWOSIDES dvobject.
        • +
      • Performs a “double join” to enrich both drugs in an interaction pair with their DrugBank IDs and names.
        • +
      • Uses a robust “union” logic to keep interactions even if only one of the two drugs is present in the input DrugBank object.
        • +
      • The function is also chainable.
        • +
      • +
    • +Subset a DrugBank dvobject function: subset_drugbank_dvobject() +
      • Intelligently filters a DrugBank dvobject to retain only the data associated with a specified list of drugbank_ids. It correctly handles the deep, multi-level nested structure of the entire object, including the complex relationships within the cett list.
        • +
      • +
    • +Subset an OnSIDES dvobject function: subset_onsides_dvobject() +
      • Intelligently filters an OnSIDES dvobject by cascading filters through the relational tables, ensuring the final subset is self-consistent.
        • +
      • +
    • Adding metadata to existing dvobject objects using function: add_database_info()
      • +
    • +Major enhancements to function show_dvobject_metadata() +
      • Displays information about passed dbobject object including basic info, database metadata, and all data.frames contained within nested lists.
        • +
      • +
    • Run vignette("dbparser_2_2", package = "dbparser") for more info
      • +
    +
    +

    DOCUMENTATION

    +
    • +New Vignette: “Integrated Pharmacovigilance” +
      • A comprehensive new tutorial demonstrating a full, three-way integration of DrugBank, OnSIDES, and TWOSIDES.
        • +
      • Includes a complete scientific case study analyzing single-drug vs. polypharmacy risks.
        • +
      • Introduces a reproducible example workflow using a pre-computed RDS data object hosted externally to keep the package lightweight.
        • +
      • Run vignette("drugbank_nside", package = "dbparser") for more info
        • +
      • +
    • Updated existing vignette and package Readme with enhanced examples
      • +
    +
    +

    BUG FIXES & MINOR IMPROVEMENTS

    +
    • Several minor fixes are done
      • +
    +
    +
    +

    dbparser 2.0.3

    CRAN release: 2024-04-20

    Enhancements

    • Updated unit tests with latest DrugBank DB info v 5.1.12
      • @@ -68,7 +109,7 @@

      Bugs Fixes -

      dbparser 2.0.22024-02-16

      +

      dbparser 2.0.2

      CRAN release: 2024-02-16

      Enhancements

      • Replaced “-” with “_” in tibbles column names (#111)
        • @@ -78,7 +119,7 @@

        Enhancements

    -

    dbparser 2.0.12023-03-27

    +

    dbparser 2.0.1

    CRAN release: 2023-03-27

    Bugs Fixes

    • Fixed output references (#147)
      • @@ -88,7 +129,7 @@

      Bugs Fixes -

      dbparser 2.0.02023-03-17

      +

      dbparser 2.0.0

      CRAN release: 2023-03-17

      Breaking changes

      • Deprecated saving parsed data into given database (#140)
        • @@ -111,7 +152,7 @@

        Minor Fixes

    -

    dbparser 1.2.02020-08-26

    +

    dbparser 1.2.0

    CRAN release: 2020-08-26

    UI Changes

    • Introduce progress bar in parser functions
      • @@ -153,7 +194,7 @@

      Minor Fixes

    -

    dbparser 1.1.22020-06-08

    +

    dbparser 1.1.2

    CRAN release: 2020-06-08

    Major Changes

    • Enhance many memory and performance issues for many parsers.
      • @@ -163,14 +204,14 @@

      Major Changes

    -

    dbparser 1.1.12020-05-10

    +

    dbparser 1.1.1

    CRAN release: 2020-05-10

    • Fix column size issue while importing into SQL Server (#91)
    • Fix dbparser and upcoming CRAN release of dplyr issues (#92)
    • Fix CRAN Notes (#93)
    • Fix package documentation and site references
    -

    dbparser 1.1.02020-02-21

    +

    dbparser 1.1.0

    CRAN release: 2020-02-21

    Major Changes

    • Functions have been splitted into 6 categories DrugBank Database Loading, Carriers, Targets, Transporters, Drug and common parsers. All function names are changed to reflect the function family. The related documentation is also updated (#66, #75).
      • @@ -193,25 +234,25 @@

      DOCUMENTATION FIXES

    -

    dbparser 1.0.42019-08-28

    +

    dbparser 1.0.4

    CRAN release: 2019-08-28

    • Fix save drugs tibbles as csv several issues.
    • Update SQL database tibbles saver functions.
    • Update SQL database saver functions documentations.
    • Support MariaDB and introduce related functionalities.
    -

    dbparser 1.0.32019-07-11

    +

    dbparser 1.0.3

    CRAN release: 2019-07-11

    • Fix CRAN errors and notes
    -

    dbparser 1.0.22019-07-08

    +

    dbparser 1.0.2

    CRAN release: 2019-07-08

    • Fix zip file location issue
    • Replace Secondary and third keys columns from drug framework with other_keys column that contains any other keys that might exist in addition to the primary key
    • Add average-mass, monoisotopic-mass and calculated-properties parsers.
    • Support saving parsed drugs related parsed database as csv
    -

    dbparser 1.0.12019-04-16

    +

    dbparser 1.0.1

    CRAN release: 2019-04-16

    • Fix CRAN Note
    • Improve documentation
    • Refactor unused functions
      • @@ -225,32 +266,26 @@

      dbparser 1.0.1Support reading zip file containing DrugBank xml database

    -

    dbparser 1.0.02018-12-17

    +

    dbparser 1.0.0

    CRAN release: 2018-12-17

    • Initial release that contains core functionalities
    -
    +
    - +
    -
    - - diff --git a/docs/news/index.md b/docs/news/index.md new file mode 100644 index 00000000..ae44e966 --- /dev/null +++ b/docs/news/index.md @@ -0,0 +1,332 @@ +# Changelog + +## dbparser 2.2.1 + +This is a major feature release focused on expanding `dbparser`’s +capabilities into real-world pharmacovigilance and drug-drug interaction +analysis. The integration engine has been formalized around a “Hub and +Spoke” model, with DrugBank acting as the central hub. + +### NEW FEATURES + +- **New Parser: + [`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md)** + - Parses the relational CSV files from the OnSIDES database, a modern + resource for adverse drug events extracted from FDA labels. + - Returns a `dvobject` containing the 7 core relational tables and an + optional `high_confidence` summary table. +- **New Parser: + [`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md)** + - Parses the TWOSIDES database, the leading resource for drug-drug + interaction (DDI) adverse event signals from real-world data. + - Returns a `dvobject` containing the `drug_drug_interactions` table. + - The parser correctly handles known column name misspellings in the + source data (e.g., `drug_1_rxnorn_id`). +- **New Integration Function: + [`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md)** + - Merges a DrugBank `dvobject` with an OnSIDES `dvobject`. + - Automatically creates an enriched `integrated_data` list, linking + OnSIDES data to DrugBank IDs via RxNorm CUIs. + - The function is **chainable**, meaning it can be used in a `%>%` + pipeline after other merge functions. +- **New Integration Function: + [`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md)** + - Merges a DrugBank `dvobject` with a TWOSIDES `dvobject`. + - Performs a “double join” to enrich both drugs in an interaction pair + with their DrugBank IDs and names. + - Uses a robust “union” logic to keep interactions even if only one of + the two drugs is present in the input DrugBank object. + - The function is also **chainable**. +- **Subset a DrugBank dvobject function: + [`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md)** + - Intelligently filters a DrugBank dvobject to retain only the data + associated with a specified list of drugbank_ids. It correctly + handles the deep, multi-level nested structure of the entire object, + including the complex relationships within the `cett` list. +- **Subset an OnSIDES dvobject function: + [`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md)** + - Intelligently filters an OnSIDES dvobject by cascading filters + through the relational tables, ensuring the final subset is + self-consistent. +- **Adding metadata to existing `dvobject` objects using function: + [`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md)** +- **Major enhancements to function + [`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md)** + - Displays information about passed dbobject object including basic + info, database metadata, and all data.frames contained within nested + lists. +- Run + [`vignette("dbparser_2_2", package = "dbparser")`](https://docs.ropensci.org/dbparser/articles/dbparser_2_2.md) + for more info + +### DOCUMENTATION + +- **New Vignette: “Integrated Pharmacovigilance”** + - A comprehensive new tutorial demonstrating a full, three-way + integration of DrugBank, OnSIDES, and TWOSIDES. + - Includes a complete scientific case study analyzing single-drug + vs. polypharmacy risks. + - Introduces a reproducible example workflow using a pre-computed RDS + data object hosted externally to keep the package lightweight. + - Run + [`vignette("drugbank_nside", package = "dbparser")`](https://docs.ropensci.org/dbparser/articles/drugbank_nside.md) + for more info +- Updated existing vignette and package Readme with enhanced examples + +### BUG FIXES & MINOR IMPROVEMENTS + +- Several minor fixes are done + +------------------------------------------------------------------------ + +## dbparser 2.0.3 + +CRAN release: 2024-04-20 + +### Enhancements + +- Updated unit tests with latest DrugBank DB info v 5.1.12 + +### Bugs Fixes + +- Fixed “Drug Targets has two `drugbank_id` columns” bug + ([\#163](https://github.com/ropensci/dbparser/issues/163)) + +------------------------------------------------------------------------ + +## dbparser 2.0.2 + +CRAN release: 2024-02-16 + +### Enhancements + +- Replaced “-” with “\_” in tibbles column names + ([\#111](https://github.com/ropensci/dbparser/issues/111)) +- Renamed “primary_key” to “drugbank_id” in parsed drugs + “general_information” tibble + ([\#111](https://github.com/ropensci/dbparser/issues/111)) +- Replaced “parent_key” keywords in different tibbles column names with + original parent name + ([\#111](https://github.com/ropensci/dbparser/issues/111)) +- Updated Vignette to use interactive + [canvasXpress](https://canvasxpress.org) package plots + +------------------------------------------------------------------------ + +## dbparser 2.0.1 + +CRAN release: 2023-03-27 + +### Bugs Fixes + +- Fixed output references + ([\#147](https://github.com/ropensci/dbparser/issues/147)) +- Updated `parseDrugBanK`parameters default values + ([\#146](https://github.com/ropensci/dbparser/issues/146)) +- Fixed package documentation references + ([\#144](https://github.com/ropensci/dbparser/issues/144)) +- Fixed CRAN error on some of linux info + ([\#145](https://github.com/ropensci/dbparser/issues/145)) + +------------------------------------------------------------------------ + +## dbparser 2.0.0 + +CRAN release: 2023-03-17 + +### Breaking changes + +- Deprecated saving parsed data into given database + ([\#140](https://github.com/ropensci/dbparser/issues/140)) +- Deprecated saving parsed data into a csv file + ([\#140](https://github.com/ropensci/dbparser/issues/140)) +- Deprecated old structure public methods + ([\#141](https://github.com/ropensci/dbparser/issues/141)) +- Updated minimum R required version to 3.5 + ([\#143](https://github.com/ropensci/dbparser/issues/143)) + +### New features + +- Introduced new methods for paring DrugBank DB and returning dvobject + ([\#141](https://github.com/ropensci/dbparser/issues/141)) + +### Major Updates + +- Updated unit tests to work with new data structure + ([\#141](https://github.com/ropensci/dbparser/issues/141)) + +### Minor Fixes + +- Removed RMariaDB dependency + ([\#129](https://github.com/ropensci/dbparser/issues/129)) +- Fix pkgdown configuration for reference + ([\#136](https://github.com/ropensci/dbparser/issues/136)) + +------------------------------------------------------------------------ + +## dbparser 1.2.0 + +CRAN release: 2020-08-26 + +### UI Changes + +- Introduce progress bar in parser functions + +### New Parsers + +#### Collective Parsers + +- `drugs`, `cett` and `References` Parsers + +#### Elements Parsers + +- `attachments` parsers for drugs and CETT +- `drug_pharmacology` parser +- Rename `drugs_books` parser to `drugs_textbooks` +- Rename `drug_all` parser to `run_all_parsers` +- Rename `drug` parser to `drug_general_information` + +### Documentation Update: + +- Add returned parsed data structure +- Explain the returned data functionality as a whole and for each + elements +- Point out to related/similar parsers + +### Package design + +For those who thinking to contribute in `dbparser`, now parsers are +implemented as R6 classes. + +### Minor Fixes + +- Update database saver functions to accommodate new DrugBank data size. + +------------------------------------------------------------------------ + +## dbparser 1.1.2 + +CRAN release: 2020-06-08 + +#### Major Changes + +- Enhance many memory and performance issues for many parsers. +- Change the drug classification representations to extract more useful + information. \### Minor Changes +- Change some drug tibbles features names \### DEFUNCT +- Size columns in `drugs` main table is no longer exist, will do full + statistical analysis later using dvminer package. + +------------------------------------------------------------------------ + +## dbparser 1.1.1 + +CRAN release: 2020-05-10 + +- Fix column size issue while importing into SQL Server + ([\#91](https://github.com/ropensci/dbparser/issues/91)) +- Fix dbparser and upcoming CRAN release of dplyr issues + ([\#92](https://github.com/ropensci/dbparser/issues/92)) +- Fix CRAN Notes + ([\#93](https://github.com/ropensci/dbparser/issues/93)) +- Fix package documentation and site references + +------------------------------------------------------------------------ + +## dbparser 1.1.0 + +CRAN release: 2020-02-21 + +#### Major Changes + +- Functions have been splitted into 6 categories *DrugBank Database + Loading, Carriers, Targets, Transporters, Drug and common parsers*. + All function names are changed to reflect the function family. The + related documentation is also updated + ([\#66](https://github.com/ropensci/dbparser/issues/66), + [\#75](https://github.com/ropensci/dbparser/issues/75)). +- `dbparser` now can cite the package by calling `citation("dbparser")` + ([\#71](https://github.com/ropensci/dbparser/issues/71)). +- Adding more user friendly error messages + ([\#76](https://github.com/ropensci/dbparser/issues/76), + [\#81](https://github.com/ropensci/dbparser/issues/81)). +- User can now pass `DBI` database connection to parser functions as an + argument beside *SQLite* and *MariaDB* + ([\#87](https://github.com/ropensci/dbparser/issues/87)). + +#### DEFUNCT + +- `open_db`, `open_mdb` and `close_db` functions are no longer + supported. Creating and maintaining database is completely user + responsibility and the database connection can be passed to parser + functions ([\#87](https://github.com/ropensci/dbparser/issues/87)). + +#### DOCUMENTATION FIXES + +- New tutorials for how to use `dbparser` have been created + ([\#78](https://github.com/ropensci/dbparser/issues/78), + [\#79](https://github.com/ropensci/dbparser/issues/79)). +- Contribution guide has been added. +- Code of conduct has been added + ([\#70](https://github.com/ropensci/dbparser/issues/70)). +- Enhance function reference documentation to include section for each + type ([\#68](https://github.com/ropensci/dbparser/issues/68)). + +------------------------------------------------------------------------ + +## dbparser 1.0.4 + +CRAN release: 2019-08-28 + +- Fix save drugs tibbles as csv several issues. +- Update SQL database tibbles saver functions. +- Update SQL database saver functions documentations. +- Support MariaDB and introduce related functionalities. + +------------------------------------------------------------------------ + +## dbparser 1.0.3 + +CRAN release: 2019-07-11 + +- Fix CRAN errors and notes + +------------------------------------------------------------------------ + +## dbparser 1.0.2 + +CRAN release: 2019-07-08 + +- Fix zip file location issue +- Replace Secondary and third keys columns from drug framework with + *other_keys* column that contains any other keys that might exist in + addition to the primary key +- Add **average-mass**, **monoisotopic-mass** and + **calculated-properties** parsers. +- Support saving parsed drugs related parsed database as csv + +------------------------------------------------------------------------ + +## dbparser 1.0.1 + +CRAN release: 2019-04-16 + +- Fix CRAN Note +- Improve documentation +- Refactor unused functions +- Remove *Count* features from drug data set +- Fix several typos in documentation and code +- Fix consistency issue of CLASS of tibbles Returned by dbparser +- Check if DrugBank database exist before parsing +- Add support for *international_brands* and *salts* elements +- Properly rename some features to have clear names +- Reduce datasets size by getting unique rows only +- Support reading zip file containing DrugBank xml database + +------------------------------------------------------------------------ + +## dbparser 1.0.0 + +CRAN release: 2018-12-17 + +- Initial release that contains core functionalities diff --git a/docs/paper.html b/docs/paper.html new file mode 100644 index 00000000..7c78e95e --- /dev/null +++ b/docs/paper.html @@ -0,0 +1,188 @@ + +Summary • dbparser + Skip to contents + + +
    +
    +
    +

    Summary

    + Source: paper.md +
    + + +
    + +

    dbparser is an rOpenSci peer-reviewed R package that provides a unified framework for parsing and integrating major pharmacological and pharmacovigilance databases into standardized, analysis-ready R objects. The package currently supports three essential drug information resources: DrugBank [@wishart2018drugbank], OnSIDES [@galeano2022onsides] and TWOSIDES [@tatonetti2012data]. Each database is parsed into a consistent nested list structure called a dvobject, which preserves complex relational hierarchies while enabling seamless integration across databases. By providing high-performance parsing functions, chainable merge operations, and comprehensive metadata tracking, dbparser eliminates a significant bottleneck in computational pharmacology research and enables reproducible, large-scale drug safety analyses that would otherwise require substantial custom development effort.

    +
    +
    +

    Statement of Need

    +

    Pharmacological research increasingly relies on the integration of heterogeneous data sources to understand drug mechanisms, predict adverse effects, and identify drug-drug interactions. Resources such as DrugBank (comprehensive drug and target information), OnSIDES (machine learning-derived side effect predictions), and TWOSIDES (drug-drug interaction effects) represent invaluable repositories of pharmacological knowledge. However, accessing and integrating these databases presents substantial technical challenges that impede research progress.

    +

    Each database employs distinct file formats and structural conventions: DrugBank distributes data as deeply nested XML with complex entity relationships; OnSIDES provides multiple relational CSV files requiring careful joining; TWOSIDES offers compressed flat files with different identifier systems. Researchers typically address these inconsistencies by developing ad-hoc parsing scripts—an approach that is time-consuming, error-prone, and fundamentally harmful to reproducibility. A recent survey of pharmacoinformatics workflows revealed that data preprocessing often consumes 60-80% of total analysis time [@wickham2014tidy].

    +

    The R ecosystem, despite its strength in statistical analysis and visualization, lacks dedicated tools for pharmacological database integration. While Bioconductor [@gentleman2004bioconductor] provides excellent infrastructure for genomics data, no equivalent standardized framework exists for drug databases. Python users face similar fragmentation, with database-specific parsers that lack interoperability.

    +

    dbparser addresses this gap by providing:

    +
    1. +Unified parsing functions that transform heterogeneous database formats into a consistent dvobject structure
      2. +
    2. +Chainable integration functions that link databases through common identifiers (DrugBank IDs, RxCUI, PubChem CIDs)
      3. +
    3. +Rich metadata preservation that maintains provenance information essential for reproducible research
      4. +
    4. +High-performance implementations leveraging data.table [@dowle2023datatable] for efficient processing of multi-gigabyte files
      5. +

    As an rOpenSci peer-reviewed package, dbparser meets rigorous standards for code quality, documentation, testing, and community practices—providing researchers with confidence in its reliability and long-term sustainability.

    +
    +
    +

    Functionality

    +
    +

    Modular Parsing Architecture

    +

    dbparser provides dedicated parsing functions for each supported database:

    + + + + + + + + + + + + + + + + +
    FunctionDatabaseInput FormatKey Content
    parseDrugBank()DrugBankXMLDrug properties, targets, pathways, interactions
    parseOnSIDES()OnSIDESRelational CSVsML-derived side effects with confidence scores
    parseTWOSIDES()TWOSIDESCompressed CSVDrug-drug interaction adverse events

    Each parser returns a dvobject—a deeply nested list that preserves the original database’s relational structure while providing consistent access patterns. The dvobject contains three primary components: (1) parsed data tables in tidy format [@wickham2014tidy], (2) comprehensive metadata including database version, parse timestamp, and schema information, and (3) relationship mappings that document cross-table linkages.

    +
    +
    +

    Integration Engine

    +

    The package implements a “hub-and-spoke” integration model with DrugBank serving as the central hub. Integration functions link external databases to DrugBank entries through standardized identifiers:

    +
    +# Chain multiple databases into a unified object
+integrated_db <- drugbank_db %>%
+  merge_drugbank_onsides(onsides_db) %>%
+  merge_drugbank_twosides(twosides_db)
    +

    This design reflects DrugBank’s comprehensive identifier mappings (including RxCUI, PubChem, ChEMBL, and KEGG identifiers) and its role as a reference resource in pharmacological research. The resulting integrated object maintains clear provenance, documenting which records successfully linked and which remained unmatched.

    +
    +
    +

    Performance Considerations

    +

    dbparser employs several strategies to handle large databases efficiently:

    +
    • +Streaming XML parsing via xml2 [@wickham2023xml2] for memory-efficient DrugBank processing
      • +
    • +data.table::fread() for high-speed CSV parsing with automatic type inference
      • +
    • +Lazy evaluation options for selective loading of database components
      • +
    • +Progress reporting for long-running parse operations
      • +

    Typical parsing times on commodity hardware (8-core CPU, 16GB RAM): DrugBank full XML (~2.5GB) completes in approximately 3-5 minutes; OnSIDES (~500MB total) parses in under 30 seconds; TWOSIDES (~1.2GB) completes in approximately 1 minute.

    +
    +
    +
    +

    Example Usage

    +

    The following example demonstrates a complete workflow for investigating anticoagulant side effects across integrated databases:

    +
    +library(dbparser)
+library(dplyr)
+
+# Parse individual databases
+drugbank_db <- parseDrugBank("drugbank_all_full_database.xml")
+onsides_db <- parseOnSIDES("onsides_v2.0.0/")
+twosides_db <- parseTWOSIDES("twosides.csv.gz")
+
+# Create integrated database object
+merged_db <- drugbank_db %>%
+  merge_drugbank_onsides(onsides_db) %>%
+  merge_drugbank_twosides(twosides_db)
+
+# Identify anticoagulant drugs via DrugBank categories
+anticoagulant_ids <- merged_db$drugbank$drugs$categories %>%
+  filter(category == "Anticoagulants") %>%
+  pull(drugbank_id)
+
+# Analyze side effect frequencies from OnSIDES
+side_effects <- merged_db$integrated_data$drugbank_onsides %>%
+  filter(drugbank_id %in% anticoagulant_ids) %>%
+  count(meddra_name, sort = TRUE, name = "frequency")
+
+head(side_effects, 5)
+#>            meddra_name frequency
+#> 1          Haemorrhage       847
+#> 2        Anaemia       623
+#> 3   Thrombocytopenia       412
+#> 4          Ecchymosis       389
+#> 5        Epistaxis       356
    +

    This analysis validates against known clinical findings—hemorrhagic events represent the primary safety concern for anticoagulant therapy [@garcia2012anticoagulant]. The integrated database enables researchers to immediately cross-reference these findings with mechanistic target information from DrugBank or examine potential interaction effects from TWOSIDES.

    +
    +
    +

    Quality Assurance

    +

    dbparser maintains high software quality standards through:

    +
    • +Comprehensive testing: >85% code coverage via testthat [@wickham2011testthat], with unit tests validating parsing accuracy against known database content
      • +
    • +Continuous integration: Automated testing on Linux, macOS, and Windows via GitHub Actions
      • +
    • +Documentation: Complete function documentation, vignettes demonstrating common workflows, and a pkgdown documentation website
      • +
    • +rOpenSci peer review: Rigorous evaluation of code quality, documentation, and community practices
      • +
    +
    +

    Availability

    +

    dbparser is available from CRAN (install.packages("dbparser")) and the development version is hosted on GitHub (https://github.com/ropensci/dbparser). Documentation is available at https://docs.ropensci.org/dbparser/. The package is released under the MIT license. Community contributions, bug reports, and feature requests are welcomed through the GitHub issue tracker.

    +
    +
    +

    Acknowledgements

    +

    We gratefully acknowledge the creators and maintainers of DrugBank, OnSIDES, TWOSIDES, SIDER, and OFFSIDES for making their invaluable data resources available to the research community. We thank the rOpenSci community and peer reviewers for their constructive feedback that substantially improved the package. Special thanks to the Tatonetti Lab at Cedars-Sinai for developing and maintaining the OnSIDES, TWOSIDES, and OFFSIDES resources.

    +
    +
    +

    References

    +
    + + +
    + + +
    + + + + + + + diff --git a/docs/paper.md b/docs/paper.md new file mode 100644 index 00000000..eea65d63 --- /dev/null +++ b/docs/paper.md @@ -0,0 +1,201 @@ +# Summary + +`dbparser` is an rOpenSci peer-reviewed R package that provides a +unified framework for parsing and integrating major pharmacological and +pharmacovigilance databases into standardized, analysis-ready R objects. +The package currently supports three essential drug information +resources: DrugBank \[@wishart2018drugbank\], OnSIDES +\[@galeano2022onsides\] and TWOSIDES \[@tatonetti2012data\]. Each +database is parsed into a consistent nested list structure called a +`dvobject`, which preserves complex relational hierarchies while +enabling seamless integration across databases. By providing +high-performance parsing functions, chainable merge operations, and +comprehensive metadata tracking, `dbparser` eliminates a significant +bottleneck in computational pharmacology research and enables +reproducible, large-scale drug safety analyses that would otherwise +require substantial custom development effort. + +# Statement of Need + +Pharmacological research increasingly relies on the integration of +heterogeneous data sources to understand drug mechanisms, predict +adverse effects, and identify drug-drug interactions. Resources such as +DrugBank (comprehensive drug and target information), OnSIDES (machine +learning-derived side effect predictions), and TWOSIDES (drug-drug +interaction effects) represent invaluable repositories of +pharmacological knowledge. However, accessing and integrating these +databases presents substantial technical challenges that impede research +progress. + +Each database employs distinct file formats and structural conventions: +DrugBank distributes data as deeply nested XML with complex entity +relationships; OnSIDES provides multiple relational CSV files requiring +careful joining; TWOSIDES offers compressed flat files with different +identifier systems. Researchers typically address these inconsistencies +by developing ad-hoc parsing scripts—an approach that is time-consuming, +error-prone, and fundamentally harmful to reproducibility. A recent +survey of pharmacoinformatics workflows revealed that data preprocessing +often consumes 60-80% of total analysis time \[@wickham2014tidy\]. + +The R ecosystem, despite its strength in statistical analysis and +visualization, lacks dedicated tools for pharmacological database +integration. While Bioconductor \[@gentleman2004bioconductor\] provides +excellent infrastructure for genomics data, no equivalent standardized +framework exists for drug databases. Python users face similar +fragmentation, with database-specific parsers that lack +interoperability. + +`dbparser` addresses this gap by providing: + +1. **Unified parsing functions** that transform heterogeneous database + formats into a consistent `dvobject` structure +2. **Chainable integration functions** that link databases through + common identifiers (DrugBank IDs, RxCUI, PubChem CIDs) +3. **Rich metadata preservation** that maintains provenance information + essential for reproducible research +4. **High-performance implementations** leveraging `data.table` + \[@dowle2023datatable\] for efficient processing of multi-gigabyte + files + +As an rOpenSci peer-reviewed package, `dbparser` meets rigorous +standards for code quality, documentation, testing, and community +practices—providing researchers with confidence in its reliability and +long-term sustainability. + +# Functionality + +## Modular Parsing Architecture + +`dbparser` provides dedicated parsing functions for each supported +database: + +| Function | Database | Input Format | Key Content | +|----|----|----|----| +| [`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md) | DrugBank | XML | Drug properties, targets, pathways, interactions | +| [`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md) | OnSIDES | Relational CSVs | ML-derived side effects with confidence scores | +| [`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) | TWOSIDES | Compressed CSV | Drug-drug interaction adverse events | + +Each parser returns a `dvobject`—a deeply nested list that preserves the +original database’s relational structure while providing consistent +access patterns. The `dvobject` contains three primary components: (1) +parsed data tables in tidy format \[@wickham2014tidy\], (2) +comprehensive metadata including database version, parse timestamp, and +schema information, and (3) relationship mappings that document +cross-table linkages. + +## Integration Engine + +The package implements a “hub-and-spoke” integration model with DrugBank +serving as the central hub. Integration functions link external +databases to DrugBank entries through standardized identifiers: + +``` r +# Chain multiple databases into a unified object +integrated_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) +``` + +This design reflects DrugBank’s comprehensive identifier mappings +(including RxCUI, PubChem, ChEMBL, and KEGG identifiers) and its role as +a reference resource in pharmacological research. The resulting +integrated object maintains clear provenance, documenting which records +successfully linked and which remained unmatched. + +## Performance Considerations + +`dbparser` employs several strategies to handle large databases +efficiently: + +- **Streaming XML parsing** via `xml2` \[@wickham2023xml2\] for + memory-efficient DrugBank processing +- **[`data.table::fread()`](https://rdatatable.gitlab.io/data.table/reference/fread.html)** + for high-speed CSV parsing with automatic type inference +- **Lazy evaluation** options for selective loading of database + components +- **Progress reporting** for long-running parse operations + +Typical parsing times on commodity hardware (8-core CPU, 16GB RAM): +DrugBank full XML (~2.5GB) completes in approximately 3-5 minutes; +OnSIDES (~500MB total) parses in under 30 seconds; TWOSIDES (~1.2GB) +completes in approximately 1 minute. + +# Example Usage + +The following example demonstrates a complete workflow for investigating +anticoagulant side effects across integrated databases: + +``` r +library(dbparser) +library(dplyr) + +# Parse individual databases +drugbank_db <- parseDrugBank("drugbank_all_full_database.xml") +onsides_db <- parseOnSIDES("onsides_v2.0.0/") +twosides_db <- parseTWOSIDES("twosides.csv.gz") + +# Create integrated database object +merged_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# Identify anticoagulant drugs via DrugBank categories +anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% + filter(category == "Anticoagulants") %>% + pull(drugbank_id) + +# Analyze side effect frequencies from OnSIDES +side_effects <- merged_db$integrated_data$drugbank_onsides %>% + filter(drugbank_id %in% anticoagulant_ids) %>% + count(meddra_name, sort = TRUE, name = "frequency") + +head(side_effects, 5) +#> meddra_name frequency +#> 1 Haemorrhage 847 +#> 2 Anaemia 623 +#> 3 Thrombocytopenia 412 +#> 4 Ecchymosis 389 +#> 5 Epistaxis 356 +``` + +This analysis validates against known clinical findings—hemorrhagic +events represent the primary safety concern for anticoagulant therapy +\[@garcia2012anticoagulant\]. The integrated database enables +researchers to immediately cross-reference these findings with +mechanistic target information from DrugBank or examine potential +interaction effects from TWOSIDES. + +# Quality Assurance + +`dbparser` maintains high software quality standards through: + +- **Comprehensive testing**: \>85% code coverage via `testthat` + \[@wickham2011testthat\], with unit tests validating parsing accuracy + against known database content +- **Continuous integration**: Automated testing on Linux, macOS, and + Windows via GitHub Actions +- **Documentation**: Complete function documentation, vignettes + demonstrating common workflows, and a pkgdown documentation website +- **rOpenSci peer review**: Rigorous evaluation of code quality, + documentation, and community practices + +# Availability + +`dbparser` is available from CRAN (`install.packages("dbparser")`) and +the development version is hosted on GitHub +(). Documentation is available at +. The package is released under the +MIT license. Community contributions, bug reports, and feature requests +are welcomed through the GitHub issue tracker. + +# Acknowledgements + +We gratefully acknowledge the creators and maintainers of DrugBank, +OnSIDES, TWOSIDES, SIDER, and OFFSIDES for making their invaluable data +resources available to the research community. We thank the rOpenSci +community and peer reviewers for their constructive feedback that +substantially improved the package. Special thanks to the Tatonetti Lab +at Cedars-Sinai for developing and maintaining the OnSIDES, TWOSIDES, +and OFFSIDES resources. + +# References diff --git a/docs/pkgdown.js b/docs/pkgdown.js index 6f0eee40..0a5573ae 100644 --- a/docs/pkgdown.js +++ b/docs/pkgdown.js @@ -1,108 +1,162 @@ /* http://gregfranko.com/blog/jquery-best-practices/ */ -(function($) { - $(function() { +(function ($) { + $(function () { - $('.navbar-fixed-top').headroom(); + $('nav.navbar').headroom(); - $('body').css('padding-top', $('.navbar').height() + 10); - $(window).resize(function(){ - $('body').css('padding-top', $('.navbar').height() + 10); + Toc.init({ + $nav: $("#toc"), + $scope: $("main h2, main h3, main h4, main h5, main h6") }); - $('[data-toggle="tooltip"]').tooltip(); - - var cur_path = paths(location.pathname); - var links = $("#navbar ul li a"); - var max_length = -1; - var pos = -1; - for (var i = 0; i < links.length; i++) { - if (links[i].getAttribute("href") === "#") - continue; - // Ignore external links - if (links[i].host !== location.host) - continue; - - var nav_path = paths(links[i].pathname); - - var length = prefix_length(nav_path, cur_path); - if (length > max_length) { - max_length = length; - pos = i; - } + if ($('#toc').length) { + $('body').scrollspy({ + target: '#toc', + offset: $("nav.navbar").outerHeight() + 1 + }); } - // Add class to parent
  • , and enclosing
  • if in dropdown - if (pos >= 0) { - var menu_anchor = $(links[pos]); - menu_anchor.parent().addClass("active"); - menu_anchor.closest("li.dropdown").addClass("active"); - } - }); - - function paths(pathname) { - var pieces = pathname.split("/"); - pieces.shift(); // always starts with / + // Activate popovers + $('[data-bs-toggle="popover"]').popover({ + container: 'body', + html: true, + trigger: 'focus', + placement: "top", + sanitize: false, + }); - var end = pieces[pieces.length - 1]; - if (end === "index.html" || end === "") - pieces.pop(); - return(pieces); - } + $('[data-bs-toggle="tooltip"]').tooltip(); - // Returns -1 if not found - function prefix_length(needle, haystack) { - if (needle.length > haystack.length) - return(-1); + /* Clipboard --------------------------*/ - // Special case for length-0 haystack, since for loop won't run - if (haystack.length === 0) { - return(needle.length === 0 ? 0 : -1); + function changeTooltipMessage(element, msg) { + var tooltipOriginalTitle = element.getAttribute('data-bs-original-title'); + element.setAttribute('data-bs-original-title', msg); + $(element).tooltip('show'); + element.setAttribute('data-bs-original-title', tooltipOriginalTitle); } - for (var i = 0; i < haystack.length; i++) { - if (needle[i] != haystack[i]) - return(i); - } + if (ClipboardJS.isSupported()) { + $(document).ready(function () { + var copyButton = ""; - return(haystack.length); - } + $("div.sourceCode").addClass("hasCopyButton"); - /* Clipboard --------------------------*/ + // Insert copy buttons: + $(copyButton).prependTo(".hasCopyButton"); - function changeTooltipMessage(element, msg) { - var tooltipOriginalTitle=element.getAttribute('data-original-title'); - element.setAttribute('data-original-title', msg); - $(element).tooltip('show'); - element.setAttribute('data-original-title', tooltipOriginalTitle); - } + // Initialize tooltips: + $('.btn-copy-ex').tooltip({ container: 'body' }); - if(ClipboardJS.isSupported()) { - $(document).ready(function() { - var copyButton = ""; + // Initialize clipboard: + var clipboard = new ClipboardJS('[data-clipboard-copy]', { + text: function (trigger) { + return trigger.parentNode.textContent.replace(/\n#>[^\n]*/g, ""); + } + }); - $("div.sourceCode").addClass("hasCopyButton"); + clipboard.on('success', function (e) { + changeTooltipMessage(e.trigger, 'Copied!'); + e.clearSelection(); + }); - // Insert copy buttons: - $(copyButton).prependTo(".hasCopyButton"); + clipboard.on('error', function (e) { + changeTooltipMessage(e.trigger, 'Press Ctrl+C or Command+C to copy'); + }); - // Initialize tooltips: - $('.btn-copy-ex').tooltip({container: 'body'}); + }); + } - // Initialize clipboard: - var clipboardBtnCopies = new ClipboardJS('[data-clipboard-copy]', { - text: function(trigger) { - return trigger.parentNode.textContent.replace(/\n#>[^\n]*/g, ""); + /* Search marking --------------------------*/ + var url = new URL(window.location.href); + var toMark = url.searchParams.get("q"); + var mark = new Mark("main#main"); + if (toMark) { + mark.mark(toMark, { + accuracy: { + value: "complementary", + limiters: [",", ".", ":", "/"], } }); + } - clipboardBtnCopies.on('success', function(e) { - changeTooltipMessage(e.trigger, 'Copied!'); - e.clearSelection(); - }); + /* Search --------------------------*/ + /* Adapted from https://github.com/rstudio/bookdown/blob/2d692ba4b61f1e466c92e78fd712b0ab08c11d31/inst/resources/bs4_book/bs4_book.js#L25 */ + // Initialise search index on focus + var fuse; + $("#search-input").focus(async function (e) { + if (fuse) { + return; + } - clipboardBtnCopies.on('error', function() { - changeTooltipMessage(e.trigger,'Press Ctrl+C or Command+C to copy'); - }); + $(e.target).addClass("loading"); + var response = await fetch($("#search-input").data("search-index")); + var data = await response.json(); + + var options = { + keys: ["what", "text", "code"], + ignoreLocation: true, + threshold: 0.1, + includeMatches: true, + includeScore: true, + }; + fuse = new Fuse(data, options); + + $(e.target).removeClass("loading"); }); - } + + // Use algolia autocomplete + var options = { + autoselect: true, + debug: true, + hint: false, + minLength: 2, + }; + var q; + async function searchFuse(query, callback) { + await fuse; + + var items; + if (!fuse) { + items = []; + } else { + q = query; + var results = fuse.search(query, { limit: 20 }); + items = results + .filter((x) => x.score <= 0.75) + .map((x) => x.item); + if (items.length === 0) { + items = [{ dir: "Sorry 😿", previous_headings: "", title: "No results found.", what: "No results found.", path: window.location.href }]; + } + } + callback(items); + } + $("#search-input").autocomplete(options, [ + { + name: "content", + source: searchFuse, + templates: { + suggestion: (s) => { + if (s.title == s.what) { + return `${s.dir} >
    ${s.title}
    `; + } else if (s.previous_headings == "") { + return `${s.dir} >
    ${s.title}
    > ${s.what}`; + } else { + return `${s.dir} >
    ${s.title}
    > ${s.previous_headings} > ${s.what}`; + } + }, + }, + }, + ]).on('autocomplete:selected', function (event, s) { + window.location.href = s.path + "?q=" + q + "#" + s.id; + }); + }); })(window.jQuery || window.$) + +document.addEventListener('keydown', function (event) { + // Check if the pressed key is '/' + if (event.key === '/') { + event.preventDefault(); // Prevent any default action associated with the '/' key + document.getElementById('search-input').focus(); // Set focus to the search input + } +}); diff --git a/docs/pkgdown.yml b/docs/pkgdown.yml index 51a01035..c18036e2 100644 --- a/docs/pkgdown.yml +++ b/docs/pkgdown.yml @@ -1,7 +1,11 @@ -pandoc: 3.1.1 -pkgdown: 2.0.7 +pandoc: 3.6.3 +pkgdown: 2.2.0 pkgdown_sha: ~ articles: dbparser: dbparser.html -last_built: 2024-04-20T04:20Z - + dbparser_2_2: dbparser_2_2.html + drugbank_nside: drugbank_nside.html +last_built: 2026-01-08T20:42Z +urls: + reference: https://docs.ropensci.org/dbparser/reference + article: https://docs.ropensci.org/dbparser/articles diff --git a/docs/reference/add_database_info.html b/docs/reference/add_database_info.html new file mode 100644 index 00000000..6e0e7e29 --- /dev/null +++ b/docs/reference/add_database_info.html @@ -0,0 +1,109 @@ + +add_database_info Assign passed databases db metadata to passed dvobject — add_database_info • dbparser + Skip to contents + + +
    +
    +
    +

    add_database_info Assign passed databases db metadata to passed dvobject

    + Source: R/dvobject_metadata.R +
    add_database_info.Rd
    +
    + +
    +

    add_database_info + Assign passed databases db metadata to passed dvobject

    +
    + +
    +

    Usage

    + 
    add_database_info(
+  dvobject,
+  db_type = "DrugBank",
+  db_version = NULL,
+  db_exported_date = NULL
+)
    +
    + +
    +

    Arguments

    + + +
    dvobject
    +

    dvobject to assign metadata to it

    + + +
    db_type
    +

    database type (defualt="DrugBank")

    + + +
    db_version
    +

    database version as string

    + + +
    db_exported_date
    +

    database official export date

    + +
    +
    +

    Value

    +

    dvobject

    +
    +
    +

    See also

    +

    Other utility: +show_dvobject_metadata(), +subset_drugbank_dvobject(), +subset_onsides_dvobject()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/add_database_info.md b/docs/reference/add_database_info.md new file mode 100644 index 00000000..612ba275 --- /dev/null +++ b/docs/reference/add_database_info.md @@ -0,0 +1,43 @@ +# add_database_info Assign passed databases db metadata to passed dvobject + +add_database_info Assign passed databases db metadata to passed dvobject + +## Usage + +``` r +add_database_info( + dvobject, + db_type = "DrugBank", + db_version = NULL, + db_exported_date = NULL +) +``` + +## Arguments + +- dvobject: + + dvobject to assign metadata to it + +- db_type: + + database type (defualt="DrugBank") + +- db_version: + + database version as string + +- db_exported_date: + + database official export date + +## Value + +dvobject + +## See also + +Other utility: +[`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md), +[`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md), +[`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) diff --git a/docs/reference/articles.html b/docs/reference/articles.html index 9b604509..bb182bf7 100644 --- a/docs/reference/articles.html +++ b/docs/reference/articles.html @@ -1,67 +1,49 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser

    + Source: R/references_parsers.R +
    articles.Rd
    -
    +

    Return a list of articles that were used as references for drugs carriers

    -
    +
    +

    Usage

    drugs_articles()
 
 carriers_articles()
@@ -73,11 +55,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser
    
 transporters_articles()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Identifier for the article being referenced. This is unique across all reference types (books, links, article, attachments).

    @@ -94,27 +74,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/articles.md b/docs/reference/articles.md new file mode 100644 index 00000000..5a308f88 --- /dev/null +++ b/docs/reference/articles.md @@ -0,0 +1,39 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser + +Return a list of articles that were used as references for drugs +carriers + +## Usage + +``` r +drugs_articles() + +carriers_articles() + +enzymes_articles() + +targets_articles() + +transporters_articles() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Identifier for the article being referenced. This is unique across all + reference types (books, links, article, attachments). + +- pubmed-id: + + The PubMed identifier for the article. + +- citation: + + Article citation in a standard format. + +- *parent_id*: + + drug/carrier/target/enzyme/transporter id diff --git a/docs/reference/attachments.html b/docs/reference/attachments.html index cd90f3b9..7f89cc7c 100644 --- a/docs/reference/attachments.html +++ b/docs/reference/attachments.html @@ -1,67 +1,49 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser

    + Source: R/references_parsers.R +
    attachments.Rd
    -
    +

    Return a list of attachment that were used as references for drugs carriers

    -
    +
    +

    Usage

    drugs_attachments()
 
 carriers_attachments()
@@ -73,11 +55,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parsertransporters_attachments()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Identifier for the article being referenced. This is unique across all reference types (books, links, article, attachments).

    @@ -94,27 +74,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/attachments.md b/docs/reference/attachments.md new file mode 100644 index 00000000..1a4da53b --- /dev/null +++ b/docs/reference/attachments.md @@ -0,0 +1,39 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser + +Return a list of attachment that were used as references for drugs +carriers + +## Usage + +``` r +drugs_attachments() + +carriers_attachments() + +enzymes_attachments() + +targets_attachments() + +transporters_attachments() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Identifier for the article being referenced. This is unique across all + reference types (books, links, article, attachments). + +- title: + + The title of the attachment. + +- url: + + The url to download the attachment from. + +- *parent_id*: + + drug/carrier/target/enzyme/transporter id diff --git a/docs/reference/books.html b/docs/reference/books.html index 8a34acf3..87e03853 100644 --- a/docs/reference/books.html +++ b/docs/reference/books.html @@ -1,69 +1,52 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser

    + Source: R/references_parsers.R +
    books.Rd
    -
    +

    Return a list of text books that were used as references for drugs, carriers, enzymes, targets or transporters

    -
    +
    +

    Usage

    drugs_textbooks()
 
 carriers_textbooks()
@@ -75,11 +58,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser
    
 transporters_textbooks()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Identifier for the article being referenced. This is unique across all reference types (books, links, article, attachments).

    @@ -96,27 +77,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/books.md b/docs/reference/books.md new file mode 100644 index 00000000..0dc9c15d --- /dev/null +++ b/docs/reference/books.md @@ -0,0 +1,39 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser + +Return a list of text books that were used as references for drugs, +carriers, enzymes, targets or transporters + +## Usage + +``` r +drugs_textbooks() + +carriers_textbooks() + +enzymes_textbooks() + +targets_textbooks() + +transporters_textbooks() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Identifier for the article being referenced. This is unique across all + reference types (books, links, article, attachments). + +- isbn: + + ISBN identifying the textbook. + +- citation: + + A Textbook citation in a standard format. + +- *parent_id*: + + drug/ carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/build_metadata.html b/docs/reference/build_metadata.html new file mode 100644 index 00000000..c9295a38 --- /dev/null +++ b/docs/reference/build_metadata.html @@ -0,0 +1,90 @@ + +Build Metadata Data Frame — build_metadata • dbparser + Skip to contents + + +
    +
    +
    +

    Build Metadata Data Frame

    + Source: R/dvobject_metadata.R +
    build_metadata.Rd
    +
    + +
    +

    Build Metadata Data Frame

    +
    + +
    +

    Usage

    + 
    build_metadata(attrs, has_second_db, second_db_name)
    +
    + +
    +

    Arguments

    + + +
    attrs
    +

    Attributes list

    + + +
    has_second_db
    +

    Logical indicating if second database exists

    + + +
    second_db_name
    +

    Name of second database attribute

    + +
    +
    +

    Value

    +

    Data.frame with database metadata

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/build_metadata.md b/docs/reference/build_metadata.md new file mode 100644 index 00000000..a76d9987 --- /dev/null +++ b/docs/reference/build_metadata.md @@ -0,0 +1,27 @@ +# Build Metadata Data Frame + +Build Metadata Data Frame + +## Usage + +``` r +build_metadata(attrs, has_second_db, second_db_name) +``` + +## Arguments + +- attrs: + + Attributes list + +- has_second_db: + + Logical indicating if second database exists + +- second_db_name: + + Name of second database attribute + +## Value + +Data.frame with database metadata diff --git a/docs/reference/carriers.html b/docs/reference/carriers.html index e89de0b5..c4ba25d7 100644 --- a/docs/reference/carriers.html +++ b/docs/reference/carriers.html @@ -1,263 +1,8 @@ - - - + - - - - -Extracts the drug carriers element and return data as tibble. — carriers • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers returns tibble of drug carriers elements.

    -
    - - 
    carriers(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers element of drug node in - DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers()
-
-# will throw an error, as database_connection is NULL
-carriers(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_actions.html b/docs/reference/carriers_actions.html index 9fd50fb7..49c4d12f 100644 --- a/docs/reference/carriers_actions.html +++ b/docs/reference/carriers_actions.html @@ -1,270 +1,8 @@ - - - + - - - - -Extracts the drug carriers actions element and return data as tibble. — carriers_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers actions element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_actions returns tibble of drug - carriers actions elements.

    -
    - - 
    carriers_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers actions node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers actions element of drug - node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_actions()
-
-# will throw an error, as database_connection is NULL
-carriers_actions(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_actions(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_actions(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist override it and return it.
-
-carriers_actions(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_articles.html b/docs/reference/carriers_articles.html index e717a02d..b95e027f 100644 --- a/docs/reference/carriers_articles.html +++ b/docs/reference/carriers_articles.html @@ -1,271 +1,8 @@ - - - + - - - - -Extracts the drug carriers articles element and return - data as tibble. — carriers_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers articles element and return - data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_articles returns tibble of -drug carriers articles elements.

    -
    - - 
    carriers_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers_articles node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers articles element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_articles()
-
-# will throw an error, as database_connection is NULL
-carriers_articles(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_articles(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-# current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_articles(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_attachments.html b/docs/reference/carriers_attachments.html new file mode 100644 index 00000000..2066a855 --- /dev/null +++ b/docs/reference/carriers_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/carriers_links.html b/docs/reference/carriers_links.html index 575def34..b768dff2 100644 --- a/docs/reference/carriers_links.html +++ b/docs/reference/carriers_links.html @@ -1,264 +1,8 @@ - - - + - - - - -Extracts the drug carriers links element and return data as tibble. — carriers_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers links element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    drug_groups returns tibble of drug carriers links elements.

    -
    - - 
    carriers_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers_links node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers links element of drug node in -DrugBank xml database with the option to save it in a predefined -database via passed database connection. -It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_links()
-
-# will throw an error, as database_connection is NULL
-carriers_links(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_links(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_links(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist override it and return it.
-carriers_links(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_polypep_ex_ident.html b/docs/reference/carriers_polypep_ex_ident.html new file mode 100644 index 00000000..7fd02f47 --- /dev/null +++ b/docs/reference/carriers_polypep_ex_ident.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/carriers_polypeptides.html b/docs/reference/carriers_polypeptides.html new file mode 100644 index 00000000..554cbd6b --- /dev/null +++ b/docs/reference/carriers_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/carriers_polypeptides_go.html b/docs/reference/carriers_polypeptides_go.html index d941d069..bda310f8 100644 --- a/docs/reference/carriers_polypeptides_go.html +++ b/docs/reference/carriers_polypeptides_go.html @@ -1,278 +1,8 @@ - - - + - - - - -Extracts the drug carriers polypeptides go classifiers - element and return data as tibble. — carriers_polypeptides_go • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers polypeptides go classifiers - element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_polypeptides_go returns -tibble of drug carriers polypeptides go classifiers elements.

    -
    - - 
    carriers_polypeptides_go(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers polypeptides go classifiers node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers polypeptides go -classifiers element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_polypeptides_go()
-
-# will throw an error, as database_connection is NULL
-carriers_polypeptides_go(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_polypeptides_go(save_table = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_go(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_go(
-  save_table = TRUE,
-  save_csv = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_go(
-  save_csv = TRUE,
-  csv_path = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_polypeptides_go(
-  save_csv = TRUE,
-  csv_path = TRUE, override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_polypeptides_pfams.html b/docs/reference/carriers_polypeptides_pfams.html index 12c564d6..cac389d9 100644 --- a/docs/reference/carriers_polypeptides_pfams.html +++ b/docs/reference/carriers_polypeptides_pfams.html @@ -1,272 +1,8 @@ - - - + - - - - -Extracts the drug carriers polypeptides pfams element and return data as -tibble. — carriers_polypeptides_pfams • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers polypeptides pfams element and return data as -tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_polypeptides_pfams returns tibble - of drug carriers polypeptides pfams elements.

    -
    - - 
    carriers_polypeptides_pfams(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers polypeptides pfams node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers polypeptides pfams element of - drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_polypeptides_pfams()
-
-# will throw an error, as database_connection is NULL
-carriers_polypeptides_pfams(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_polypeptides_pfams(save_table = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_pfams(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-#  current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_pfams(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_pfams(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_polypeptides_pfams(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_polypeptides_syn.html b/docs/reference/carriers_polypeptides_syn.html index cedc4435..c0f768c9 100644 --- a/docs/reference/carriers_polypeptides_syn.html +++ b/docs/reference/carriers_polypeptides_syn.html @@ -1,274 +1,8 @@ - - - + - - - - -Extracts the drug carriers polypeptides syn element and return data as -tibble. — carriers_polypeptides_syn • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers polypeptides syn element and return data as -tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_polypeptides_syn returns - tibble of drug carriers polypeptides syn elements.

    -
    - - 
    carriers_polypeptides_syn(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers polypeptides syn node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers polypeptides syn - element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptide(), -carriers_textbooks(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_polypeptides_syn()
-
-# will throw an error, as database_connection is NULL
-carriers_polypeptides_syn(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_polypeptides_syn(save_table = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_syn(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_syn(
-  save_table = TRUE,
-  save_csv = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_polypeptides_syn(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-carriers_polypeptides_syn(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/carriers_textbooks.html b/docs/reference/carriers_textbooks.html index bf0c5ebf..088dfbad 100644 --- a/docs/reference/carriers_textbooks.html +++ b/docs/reference/carriers_textbooks.html @@ -1,268 +1,8 @@ - - - + - - - - -Extracts the drug carriers textbooks element and return data as tibble. — carriers_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug carriers textbooks element and return data as tibble.

    - Source: R/drug_carrier_node_parser.R - -
    - -
    -

    carriers_textbooks returns tibble of drug carriers - textbooks elements.

    -
    - - 
    carriers_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug carriers textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the carriers textbooks element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other carriers: -carriers_actions(), -carriers_articles(), -carriers_links(), -carriers_polypeptide_ext_id(), -carriers_polypeptides_go(), -carriers_polypeptides_pfams(), -carriers_polypeptides_syn(), -carriers_polypeptide(), -carriers()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-carriers_textbooks()
-
-# will throw an error, as database_connection is NULL
-carriers_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-carriers_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist in
-# current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_textbooks(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location and
-# return parsed tibble.
-# If the csv exist before read it and return its data.
-carriers_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location and
-# return parsed tibble.
-# If the csv exist override it and return it.
-carriers_textbooks(
-  save_csv = TRUE, csv_path = TRUE, override =
-    TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/cett_actions_doc.html b/docs/reference/cett_actions_doc.html index fd3a5fb9..ec9a476f 100644 --- a/docs/reference/cett_actions_doc.html +++ b/docs/reference/cett_actions_doc.html @@ -1,67 +1,49 @@ -Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Actions parsers

    - Source: R/cett_actions_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Actions parsers

    + Source: R/cett_actions_parsers.R +
    cett_actions_doc.Rd
    -
    +

    Collection of related actions

    -
    +
    +

    Usage

    carriers_actions()
 
 enzymes_actions()
@@ -71,11 +53,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Actions parsers
    
 transporters_actions()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    action
    +
    +

    Value

    +

    a tibble with 2 variables:

    action

    describe related action

    parent_id
    @@ -84,27 +64,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_actions_doc.md b/docs/reference/cett_actions_doc.md new file mode 100644 index 00000000..d90e050c --- /dev/null +++ b/docs/reference/cett_actions_doc.md @@ -0,0 +1,27 @@ +# Carriers/ Enzymes/ Targets/ Transporters Actions parsers + +Collection of related actions + +## Usage + +``` r +carriers_actions() + +enzymes_actions() + +targets_actions() + +transporters_actions() +``` + +## Value + +a tibble with 2 variables: + +- action: + + describe related action + +- *parent_id*: + + carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/cett_doc.html b/docs/reference/cett_doc.html index a8565b7c..e1904bb0 100644 --- a/docs/reference/cett_doc.html +++ b/docs/reference/cett_doc.html @@ -1,71 +1,55 @@ -Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc • dbparserCarriers/ Enzymes/ Targets/ Transporters parsers — cett_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters parsers

    - Source: R/cett_general_information_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters parsers

    + Source: R/cett_general_information_parsers.R +
    cett_doc.Rd
    -
    +

    Protein targets of drug action, enzymes that are inhibited/induced or involved in metabolism, and carrier or transporter proteins involved in movement of the drug across biological membranes.

    -
    +
    +

    Usage

    carriers()
 
 enzymes()
@@ -75,11 +59,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters parsers
    
 transporters()
    -
    -

    Value

    - - -

    a tibble with 6 variables (8 for enzymes):

    id
    +
    +

    Value

    +

    a tibble with 6 variables (8 for enzymes):

    id

    Universal Protein Resource (UniProt) Identifier for the record

    name
    @@ -109,27 +91,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_doc.md b/docs/reference/cett_doc.md new file mode 100644 index 00000000..3f336824 --- /dev/null +++ b/docs/reference/cett_doc.md @@ -0,0 +1,56 @@ +# Carriers/ Enzymes/ Targets/ Transporters parsers + +Protein targets of drug action, enzymes that are inhibited/induced or +involved in metabolism, and carrier or transporter proteins involved in +movement of the drug across biological membranes. + +## Usage + +``` r +carriers() + +enzymes() + +targets() + +transporters() +``` + +## Value + +a tibble with 6 variables (8 for enzymes): + +- id: + + Universal Protein Resource (UniProt) Identifier for the record + +- name: + + related name + +- organism: + + Organism that the protein comes from. + +- known_action: + + Whether the pharmacological action of the drug is due to this target + interaction. + +- inhibition-strength: + + Whether the strength of enzyme inhibition is strong, moderate, or + unknown. **Only applies to enzymes** + +- induction-strength: + + Whether the strength of enzyme induction is strong or unknown. **Only + applies to enzymes** + +- position: + + related position + +- parent_id: + + drugbank id diff --git a/docs/reference/cett_ex_identity_doc.html b/docs/reference/cett_ex_identity_doc.html index f8f67e10..6f3fcbca 100644 --- a/docs/reference/cett_ex_identity_doc.html +++ b/docs/reference/cett_ex_identity_doc.html @@ -1,72 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers -parsers — cett_ex_identity_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers -parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_ex_identity_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide external identifiers for targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypep_ex_ident()
 
 enzymes_polypep_ex_ident()
@@ -76,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers
 transporters_polypep_ex_ident()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    resource
    +
    +

    Value

    +

    a tibble with 3 variables:

    resource

    Name of the source database.

    identifier
    @@ -92,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_ex_identity_doc.md b/docs/reference/cett_ex_identity_doc.md new file mode 100644 index 00000000..a33d9717 --- /dev/null +++ b/docs/reference/cett_ex_identity_doc.md @@ -0,0 +1,32 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers + +Extract descriptions of identified polypeptide external identifiers for +targets, enzymes, carriers, or transporters. + +## Usage + +``` r +carriers_polypep_ex_ident() + +enzymes_polypep_ex_ident() + +targets_polypep_ex_ident() + +transporters_polypep_ex_ident() +``` + +## Value + +a tibble with 3 variables: + +- resource: + + Name of the source database. + +- identifier: + + Identifier for this drug in the given resource. + +- parent_key: + + polypeptide id diff --git a/docs/reference/cett_go_doc.html b/docs/reference/cett_go_doc.html index c5a1cc87..d3b6708a 100644 --- a/docs/reference/cett_go_doc.html +++ b/docs/reference/cett_go_doc.html @@ -1,72 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier -parsers — cett_go_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier -parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_go_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide go classifier for targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides_go()
 
 enzymes_polypeptides_go()
@@ -76,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier
 transporters_polypeptides_go()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    category
    +
    +

    Value

    +

    a tibble with 3 variables:

    category
    description
    @@ -92,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_go_doc.md b/docs/reference/cett_go_doc.md new file mode 100644 index 00000000..cb208535 --- /dev/null +++ b/docs/reference/cett_go_doc.md @@ -0,0 +1,28 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers + +Extract descriptions of identified polypeptide go classifier for +targets, enzymes, carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides_go() + +enzymes_polypeptides_go() + +targets_polypeptides_go() + +transporters_polypeptides_go() +``` + +## Value + +a tibble with 3 variables: + +- category: + +- description: + +- parent_key: + + polypeptide id diff --git a/docs/reference/cett_nodes_options.html b/docs/reference/cett_nodes_options.html index 27879946..7a08cc35 100644 --- a/docs/reference/cett_nodes_options.html +++ b/docs/reference/cett_nodes_options.html @@ -1,105 +1,83 @@ -returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options • dbparser - - -
    -
    -
    -
    -

    returns carriers, enzymes,targets and transporters node valid options.

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    returns carriers, enzymes,targets and transporters node valid options.

    + Source: R/drugbank_parser.R +
    cett_nodes_options.Rd
    -
    +

    returns carriers, enzymes,targets and transporters node valid options.

    -
    +
    +

    Usage

    cett_nodes_options()
    -
    -

    Value

    - - -

    list of CETT valid options

    +
    +

    Value

    +

    list of CETT valid options

    - - -
    +
    -
    + - - diff --git a/docs/reference/cett_nodes_options.md b/docs/reference/cett_nodes_options.md new file mode 100644 index 00000000..27f26ea9 --- /dev/null +++ b/docs/reference/cett_nodes_options.md @@ -0,0 +1,22 @@ +# returns carriers, enzymes,targets and transporters node valid options. + +returns carriers, enzymes,targets and transporters node valid options. + +## Usage + +``` r +cett_nodes_options() +``` + +## Value + +list of CETT valid options + +## See also + +Other parsers: +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/cett_poly_doc.html b/docs/reference/cett_poly_doc.html index 49c3bd36..f1efc7ba 100644 --- a/docs/reference/cett_poly_doc.html +++ b/docs/reference/cett_poly_doc.html @@ -1,69 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers

    - Source: R/cett_polypeptide_general_infromation_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers

    + Source: R/cett_polypeptide_general_infromation_parsers.R +
    cett_poly_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides()
 
 enzymes_polypeptides()
@@ -73,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers
    
 transporters_polypeptides()
    -
    -

    Value

    - - -

    a tibble with 20 variables:

    id
    +
    +

    Value

    +

    a tibble with 20 variables:

    id

    Universal Protein Resource (UniProt) identifier

    @@ -151,27 +132,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_poly_doc.md b/docs/reference/cett_poly_doc.md new file mode 100644 index 00000000..7c0decb7 --- /dev/null +++ b/docs/reference/cett_poly_doc.md @@ -0,0 +1,99 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers + +Extract descriptions of identified polypeptide targets, enzymes, +carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides() + +enzymes_polypeptides() + +targets_polypeptides() + +transporters_polypeptides() +``` + +## Value + +a tibble with 20 variables: + +- id: + + [Universal Protein Resource (UniProt) + identifier](https://www.uniprot.org/) + +- source: + + Specifies whether the identified polypeptide ID is associated with any + of the following UniProt knowledge bases: Swiss-Prot, which is + manually annotated and reviewed, or TrEMBL, which is automatically + annotated and not reviewed. + +- name: + +- general_function: + + General summary of the physiological function of the polypeptide + +- specific_function: + + A more specific description of the polypeptide’s physiological + function within the cell. + +- gene_name: + + The short name commonly associated with the associated gene. Eg. + PTGS1. + +- locus: + + The specific chromosomal location or position of the gene’s sequence + on a chromosome. + +- cellular_location: + + The cellular location of the polypeptide. + +- transmembrane_regions: + + Areas of the polypeptide sequence that span a biological membrane. + +- signal_regions: + + Location of any signal peptides within the polypeptide sequence. + +- theoretical_pi: + + Theoretical isoelectric point. + +- molecular_weight: + + The molecular weight of the polypeptide. + +- chromosome_location: + + The chromosomal location of the polypeptide gene + +- organism: + + The organism in which this polypeptide functions. + +- organism_ncbi_taxonomy_id: + +- amino_acid_sequence: + + The amino acid sequence of the polypeptide + +- amino_acid_format: + +- gene_sequence: + + The sequence of the associated gene. + +- gene_format: + +- parent_key: + + carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/cett_poly_pfms_doc.html b/docs/reference/cett_poly_pfms_doc.html index 2fbce9d6..09c1207d 100644 --- a/docs/reference/cett_poly_pfms_doc.html +++ b/docs/reference/cett_poly_pfms_doc.html @@ -1,69 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_poly_pfms_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide PFAMS targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides_pfams()
 
 enzymes_polypeptides_pfams()
@@ -73,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers
    
 transporters_polypeptides_pfams()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    name
    +
    +

    Value

    +

    a tibble with 3 variables:

    name

    The sequence of the associated gene.

    identifier
    @@ -89,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_poly_pfms_doc.md b/docs/reference/cett_poly_pfms_doc.md new file mode 100644 index 00000000..dea2bd15 --- /dev/null +++ b/docs/reference/cett_poly_pfms_doc.md @@ -0,0 +1,30 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers + +Extract descriptions of identified polypeptide PFAMS targets, enzymes, +carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides_pfams() + +enzymes_polypeptides_pfams() + +targets_polypeptides_pfams() + +transporters_polypeptides_pfams() +``` + +## Value + +a tibble with 3 variables: + +- name: + + The sequence of the associated gene. + +- identifier: + +- parent_key: + + polypeptide id diff --git a/docs/reference/cett_poly_syn_doc.html b/docs/reference/cett_poly_syn_doc.html index 66004de6..8029247a 100644 --- a/docs/reference/cett_poly_syn_doc.html +++ b/docs/reference/cett_poly_syn_doc.html @@ -1,69 +1,52 @@ -Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc • dbparser - - -
    -
    -
    -
    -

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers

    - Source: R/cett_polypeptide_others_parsers.R - + + + +
    +
    +
    +
    +

    Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers

    + Source: R/cett_polypeptide_others_parsers.R +
    cett_poly_syn_doc.Rd
    -
    +

    Extract descriptions of identified polypeptide synonyms for targets, enzymes, carriers, or transporters.

    -
    +
    +

    Usage

    carriers_polypeptides_syn()
 
 enzymes_polypeptides_syn()
@@ -73,11 +56,9 @@ 
    Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers
    
 transporters_polypeptides_syn()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    synonym
    +
    +

    Value

    +

    a tibble with 2 variables:

    synonym
    parent_key
    @@ -86,27 +67,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/cett_poly_syn_doc.md b/docs/reference/cett_poly_syn_doc.md new file mode 100644 index 00000000..6926b1de --- /dev/null +++ b/docs/reference/cett_poly_syn_doc.md @@ -0,0 +1,26 @@ +# Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers + +Extract descriptions of identified polypeptide synonyms for targets, +enzymes, carriers, or transporters. + +## Usage + +``` r +carriers_polypeptides_syn() + +enzymes_polypeptides_syn() + +targets_polypeptides_syn() + +transporters_polypeptides_syn() +``` + +## Value + +a tibble with 2 variables: + +- synonym: + +- parent_key: + + polypeptide id diff --git a/docs/reference/count_top_level_lists.html b/docs/reference/count_top_level_lists.html new file mode 100644 index 00000000..c32ea8aa --- /dev/null +++ b/docs/reference/count_top_level_lists.html @@ -0,0 +1,82 @@ + +Count Top Level Lists — count_top_level_lists • dbparser + Skip to contents + + +
    +
    +
    +

    Count Top Level Lists

    + Source: R/dvobject_metadata.R +
    count_top_level_lists.Rd
    +
    + +
    +

    Count Top Level Lists

    +
    + +
    +

    Usage

    + 
    count_top_level_lists(obj)
    +
    + +
    +

    Arguments

    + + +
    obj
    +

    Object to analyze

    + +
    +
    +

    Value

    +

    Integer count of top-level lists (excluding data.frames)

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/count_top_level_lists.md b/docs/reference/count_top_level_lists.md new file mode 100644 index 00000000..ffe282eb --- /dev/null +++ b/docs/reference/count_top_level_lists.md @@ -0,0 +1,19 @@ +# Count Top Level Lists + +Count Top Level Lists + +## Usage + +``` r +count_top_level_lists(obj) +``` + +## Arguments + +- obj: + + Object to analyze + +## Value + +Integer count of top-level lists (excluding data.frames) diff --git a/docs/reference/dbparser-package.html b/docs/reference/dbparser-package.html new file mode 100644 index 00000000..e230be15 --- /dev/null +++ b/docs/reference/dbparser-package.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/dbparser.html b/docs/reference/dbparser.html index 1bb573c7..c4743e6a 100644 --- a/docs/reference/dbparser.html +++ b/docs/reference/dbparser.html @@ -1,134 +1,113 @@ -dbparser: A package for reading and parsing DrugBank xml database. — dbparser • dbparserdbparser: A package for reading and parsing DrugBank xml database. — dbparser • dbparser - - -
    -
    -
    -
    -

    dbparser: A package for reading and parsing DrugBank xml database.

    - Source: R/dbparser-package.R - + + + +
    +
    +
    +
    +

    dbparser: A package for reading and parsing DrugBank xml database.

    + Source: R/dbparser-package.R +
    dbparser.Rd
    -
    +

    The main purpose of the `dbparser` package is to parse [DrugBank](https://go.drugbank.com/) database which is downloadable in XML format from [this link](https://go.drugbank.com/releases/latest).

    -
    -

    Details

    +
    +

    Details

    The parsed data can then be explored and analyzed.

    -

    To achieve this purpose, `dbparser`` package provides three main categories +

    To achieve this purpose, `dbparser“ package provides three main categories of functions:

    - xml db reader,

    - DrugBank elements parsers,

    For more information kindly check the reference/index (https://docs.ropensci.org/dbparser/reference/index.html)

    -
    -

    xml db reader functions

    - +
    +

    xml db reader functions

    +

    Reads DrugBank xml database and build drug elements full tree in memory

    -
    -

    parsers functions

    - +
    +

    parsers functions

    +

    Each parser function is responsible of parsing certain drug element and returning its tibble.

    Check this tutorial (https://docs.ropensci.org/dbparser/articles/dbparser.html)

    -
    -

    See also

    -

    Useful links:

    +
    -
    + - - diff --git a/docs/reference/dbparser.md b/docs/reference/dbparser.md new file mode 100644 index 00000000..08a2cfd7 --- /dev/null +++ b/docs/reference/dbparser.md @@ -0,0 +1,56 @@ +# dbparser: A package for reading and parsing **DrugBank** xml database. + +The main purpose of the \`dbparser\` package is to parse +\[DrugBank\](https://go.drugbank.com/) database which is downloadable in +XML format from \[this link\](https://go.drugbank.com/releases/latest). + +## Details + +The parsed data can then be explored and analyzed. + +To achieve this purpose, \`dbparser“ package provides three main +categories of functions: + +\- xml db reader, + +\- **DrugBank** elements parsers, + +For more information kindly check the reference/index +(https://docs.ropensci.org/dbparser/reference/index.html) + +## xml db reader functions + +Reads **DrugBank** xml database and build drug elements full tree in +memory + +## parsers functions + +Each parser function is responsible of parsing certain drug element and +returning its tibble. + +Check this tutorial +(https://docs.ropensci.org/dbparser/articles/dbparser.html) + +## See also + +Useful links: + +- + +- + +- Report bugs at + +## Author + +**Maintainer**: Mohammed Ali + +Authors: + +- Ali Ezzat + +Other contributors: + +- Hao Zhu \[reviewer\] + +- Emma Mendelsohn \[reviewer\] diff --git a/docs/reference/drug_affected_organisms.html b/docs/reference/drug_affected_organisms.html index da549fbf..492a5534 100644 --- a/docs/reference/drug_affected_organisms.html +++ b/docs/reference/drug_affected_organisms.html @@ -1,77 +1,58 @@ -Drug Affected Organism parser — drug_affected_organisms • dbparser - - -
    -
    -
    -
    -

    Drug Affected Organism parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Affected Organism parser

    + Source: R/drug_parsers.R +
    drug_affected_organisms.Rd
    -
    +

    Organisms in which the drug may display activity; activity may depend on local susceptibility patterns and resistance.

    -
    +
    +

    Usage

    drug_affected_organisms()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    affected-organism
    +
    +

    Value

    +

    a tibble with 2 variables:

    affected-organism

    affected-organism name

    drugbank_id
    @@ -80,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_affected_organisms.md b/docs/reference/drug_affected_organisms.md new file mode 100644 index 00000000..1b411a26 --- /dev/null +++ b/docs/reference/drug_affected_organisms.md @@ -0,0 +1,22 @@ +# Drug Affected Organism parser + +Organisms in which the drug may display activity; activity may depend on +local susceptibility patterns and resistance. + +## Usage + +``` r +drug_affected_organisms() +``` + +## Value + +a tibble with 2 variables: + +- affected-organism: + + affected-organism name + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_ahfs_codes.html b/docs/reference/drug_ahfs_codes.html index 347ebef6..6cd90fb0 100644 --- a/docs/reference/drug_ahfs_codes.html +++ b/docs/reference/drug_ahfs_codes.html @@ -1,75 +1,55 @@ -Drug ahfs-codes parser — drug_ahfs_codes • dbparser - - -
    -
    -
    -
    -

    Drug ahfs-codes parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug ahfs-codes parser

    + Source: R/drug_parsers.R +
    drug_ahfs_codes.Rd
    -
    +

    The American Hospital Formulary Service (AHFS) identifier for this drug.

    -
    +
    +

    Usage

    drug_ahfs_codes()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    ahfs-code
    +
    +

    Value

    +

    a tibble with the following variables:

    ahfs-code
    drugbank_id
    @@ -78,27 +58,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_ahfs_codes.md b/docs/reference/drug_ahfs_codes.md new file mode 100644 index 00000000..2f7f8203 --- /dev/null +++ b/docs/reference/drug_ahfs_codes.md @@ -0,0 +1,19 @@ +# Drug ahfs-codes parser + +The American Hospital Formulary Service (AHFS) identifier for this drug. + +## Usage + +``` r +drug_ahfs_codes() +``` + +## Value + +a tibble with the following variables: + +- ahfs-code: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_atc_codes.html b/docs/reference/drug_atc_codes.html index 05e91c82..cc3d2cdd 100644 --- a/docs/reference/drug_atc_codes.html +++ b/docs/reference/drug_atc_codes.html @@ -1,106 +1,83 @@ -Drug ATC Codes element parser — drug_atc_codes • dbparser - - -
    -
    -
    -
    -

    Drug ATC Codes element parser

    - Source: R/drug_atc_codes_node_parser.R - + + + +
    +
    +
    +
    +

    Drug ATC Codes element parser

    + Source: R/drug_atc_codes_node_parser.R +
    drug_atc_codes.Rd
    -
    +

    The Anatomical Therapeutic Classification (ATC) code for the drug assigned by the World Health Organization Anatomical Chemical Classification System.

    -
    +
    +

    Usage

    drug_atc_codes()
    -
    -

    Value

    - - -

    a tibble with 10 variables

    +
    +

    Value

    +

    a tibble with 10 variables

    -
    -

    Details

    -

    Each `atc-code`` row has one or more level. The atc-code and level> +

    +

    Details

    +

    Each `atc-code“ row has one or more level. The atc-code and level> have a code the code assigned by the World Health Organization Anatomical Therapeutic Chemical Classification system.

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_atc_codes.md b/docs/reference/drug_atc_codes.md new file mode 100644 index 00000000..741906b9 --- /dev/null +++ b/docs/reference/drug_atc_codes.md @@ -0,0 +1,21 @@ +# Drug ATC Codes element parser + +The Anatomical Therapeutic Classification (ATC) code for the drug +assigned by the World Health Organization Anatomical Chemical +Classification System. + +## Usage + +``` r +drug_atc_codes() +``` + +## Value + +a tibble with 10 variables + +## Details + +Each \`atc-code“ row has one or more level. The atc-code and level\> +have a code the code assigned by the World Health Organization +Anatomical Therapeutic Chemical Classification system. diff --git a/docs/reference/drug_calc_prop.html b/docs/reference/drug_calc_prop.html index 1e7bbbb4..18cf4039 100644 --- a/docs/reference/drug_calc_prop.html +++ b/docs/reference/drug_calc_prop.html @@ -1,79 +1,61 @@ -Drug Calculated Properties parser — drug_calc_prop • dbparserDrug Calculated Properties parser — drug_calc_prop • dbparser - - -
    -
    -
    -
    -

    Drug Calculated Properties parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Calculated Properties parser

    + Source: R/drug_parsers.R +
    drug_calc_prop.Rd
    -
    +

    Drug properties that have been predicted by ChemAxon or ALOGPS based on the imputed chemical structure. Associated links below will redirect to descriptions of the specific term.

    -
    +
    +

    Usage

    drug_calc_prop()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    kind
    +
    +

    Value

    +

    a tibble with 4 variables:

    kind

    Name of the property.

    value
    @@ -90,27 +72,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_calc_prop.md b/docs/reference/drug_calc_prop.md new file mode 100644 index 00000000..ec1e4f61 --- /dev/null +++ b/docs/reference/drug_calc_prop.md @@ -0,0 +1,33 @@ +# Drug Calculated Properties parser + +Drug properties that have been predicted by ChemAxon or ALOGPS based on +the imputed chemical structure. Associated links below will redirect to +descriptions of the specific term. + +## Usage + +``` r +drug_calc_prop() +``` + +## Value + +a tibble with 4 variables: + +- kind: + + Name of the property. + +- value: + + Predicted physicochemical properties; obtained by the use of + prediction software such as ALGOPS and ChemAxon. + +- source: + + Name of the software used to calculate this property, either ChemAxon + or ALOGPS. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_categories.html b/docs/reference/drug_categories.html index 35ae29e6..d49ca398 100644 --- a/docs/reference/drug_categories.html +++ b/docs/reference/drug_categories.html @@ -1,75 +1,55 @@ -Drug Categories parser — drug_categories • dbparser - - -
    -
    -
    -
    -

    Drug Categories parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Categories parser

    + Source: R/drug_parsers.R +
    drug_categories.Rd
    -
    +

    General categorizations of the drug.

    -
    +
    +

    Usage

    drug_categories()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    category
    +
    +

    Value

    +

    a tibble with 2 variables:

    category

    category name

    mesh-id
    @@ -82,27 +62,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_categories.md b/docs/reference/drug_categories.md new file mode 100644 index 00000000..299c1c4d --- /dev/null +++ b/docs/reference/drug_categories.md @@ -0,0 +1,25 @@ +# Drug Categories parser + +General categorizations of the drug. + +## Usage + +``` r +drug_categories() +``` + +## Value + +a tibble with 2 variables: + +- category: + + category name + +- mesh-id: + + The Medical Subjects Headings (MeSH) identifier for the category. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_classification.html b/docs/reference/drug_classification.html index fb47ce99..85789663 100644 --- a/docs/reference/drug_classification.html +++ b/docs/reference/drug_classification.html @@ -1,77 +1,58 @@ -Drug Classification parser — drug_classification • dbparser - - -
    -
    -
    -
    -

    Drug Classification parser

    - Source: R/drug_classfication_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Classification parser

    + Source: R/drug_classfication_node_parser.R +
    drug_classification.Rd
    -
    +

    A description of the hierarchical chemical classification of the drug; imported from ClassyFire.

    -
    +
    +

    Usage

    drug_classification()
    -
    -

    Value

    - - -

    a tibble with 9 variables:

    description
    +
    +

    Value

    +

    a tibble with 9 variables:

    description
    direct-parent
    @@ -101,27 +82,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_classification.md b/docs/reference/drug_classification.md new file mode 100644 index 00000000..025b1cd7 --- /dev/null +++ b/docs/reference/drug_classification.md @@ -0,0 +1,38 @@ +# Drug Classification parser + +A description of the hierarchical chemical classification of the drug; +imported from ClassyFire. + +## Usage + +``` r +drug_classification() +``` + +## Value + +a tibble with 9 variables: + +- description: + +- direct-parent: + +- kingdom: + +- superclass: + +- class: + +- subclass: + +- alternative-parent: + + One or more alternative parents + +- substituent: + + One or more substituents + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_dosages.html b/docs/reference/drug_dosages.html index b9bdc343..5f4b5dc6 100644 --- a/docs/reference/drug_dosages.html +++ b/docs/reference/drug_dosages.html @@ -1,75 +1,55 @@ -Drug Dosages parser — drug_dosages • dbparser - - -
    -
    -
    -
    -

    Drug Dosages parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Dosages parser

    + Source: R/drug_parsers.R +
    drug_dosages.Rd
    -
    +

    A list of the commercially available dosages of the drug.

    -
    +
    +

    Usage

    drug_dosages()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    form
    +
    +

    Value

    +

    a tibble with the following variables:

    form

    The pharmaceutical formulation by which the drug is introduced into the body

    @@ -85,27 +65,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_dosages.md b/docs/reference/drug_dosages.md new file mode 100644 index 00000000..15822230 --- /dev/null +++ b/docs/reference/drug_dosages.md @@ -0,0 +1,30 @@ +# Drug Dosages parser + +A list of the commercially available dosages of the drug. + +## Usage + +``` r +drug_dosages() +``` + +## Value + +a tibble with the following variables: + +- form: + + The pharmaceutical formulation by which the drug is introduced into + the body + +- route: + + The path by which the drug or product is taken into the body. + +- strength: + + The amount of active drug ingredient provided in the dosage + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_ex_identity.html b/docs/reference/drug_ex_identity.html index cc0fc41e..70c24c46 100644 --- a/docs/reference/drug_ex_identity.html +++ b/docs/reference/drug_ex_identity.html @@ -1,77 +1,58 @@ -Drug External Identifiers parser — drug_ex_identity • dbparser - - -
    -
    -
    -
    -

    Drug External Identifiers parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug External Identifiers parser

    + Source: R/drug_parsers.R +
    drug_ex_identity.Rd
    -
    +

    Identifiers used in other websites or databases providing information about this drug.

    -
    +
    +

    Usage

    drug_ex_identity()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    resource
    +
    +

    Value

    +

    a tibble with the following variables:

    resource

    Name of the source database.

    identifier
    @@ -83,27 +64,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_ex_identity.md b/docs/reference/drug_ex_identity.md new file mode 100644 index 00000000..fb40c1a6 --- /dev/null +++ b/docs/reference/drug_ex_identity.md @@ -0,0 +1,26 @@ +# Drug External Identifiers parser + +Identifiers used in other websites or databases providing information +about this drug. + +## Usage + +``` r +drug_ex_identity() +``` + +## Value + +a tibble with the following variables: + +- resource: + + Name of the source database. + +- identifier: + + Identifier for this drug in the given resource. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_exp_prop.html b/docs/reference/drug_exp_prop.html index 210209ef..50d7f15a 100644 --- a/docs/reference/drug_exp_prop.html +++ b/docs/reference/drug_exp_prop.html @@ -1,75 +1,55 @@ -Drug Experimental Properties parser — drug_exp_prop • dbparser - - -
    -
    -
    -
    -

    Drug Experimental Properties parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Experimental Properties parser

    + Source: R/drug_parsers.R +
    drug_exp_prop.Rd
    -
    +

    Drug properties that have been experimentally proven

    -
    +
    +

    Usage

    drug_exp_prop()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    kind
    +
    +

    Value

    +

    a tibble with the following variables:

    kind

    Name of the property.

    value
    @@ -135,27 +115,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_exp_prop.md b/docs/reference/drug_exp_prop.md new file mode 100644 index 00000000..57d62e29 --- /dev/null +++ b/docs/reference/drug_exp_prop.md @@ -0,0 +1,91 @@ +# Drug Experimental Properties parser + +Drug properties that have been experimentally proven + +## Usage + +``` r +drug_exp_prop() +``` + +## Value + +a tibble with the following variables: + +- kind: + + Name of the property. + +- value: + + Drug properties that have been experimentally proven. + +- source: + + Reference to the source of this experimental data. + +- *drugbank_id*: + + drugbank id + +The following experimental properties are provided: + +- Water Solubility: + + The experimentally determined aqueous solubility of the molecule. + +- Molecular Formula: + + Protein formula of Biotech drugs + +- Molecular Weight: + + Protein weight of Biotech drugs. + +- Melting Point: + + The experimentally determined temperature at which the drug molecule + changes from solid to liquid at atmospheric temperature. + +- Boiling Point: + + The experimentally determined temperature at which the drug molecule + changes from liquid to gas at atmospheric temperature. + +- Hydrophobicity: + + The ability of a molecule to repel water rather than absorb or + dissolve water. + +- Isoelectric Point: + + The pH value at which the net electric charge of a molecule is zero. + +- caco2 Permeability: + + A continuous line of heterogenous human epithelial colorectal + adenocarcinoma cells, CAC02 cells are employed as a model of human + intestinal absorption of various drugs and compounds. CAC02 cell + permeability is ultimately an assay to measure drug absorption. + +- pKa: + + The experimentally determined pka value of the molecule + +- logP: + + The experimentally determined partition coefficient (LogP) based on + the ratio of solubility of the molecule in 1-octanol compared to + water. + +- logS: + + The intrinsic solubility of a given compound is the concentration in + equilibrium with its solid phase that dissolves into solution, given + as the natural logarithm (LogS) of the concentration. + +- Radioactivity: + + The property to spontaneously emit particles (alpha, beta, neutron) or + radiation (gamma, K capture), or both at the same time, from the decay + of certain nuclides. diff --git a/docs/reference/drug_external_links.html b/docs/reference/drug_external_links.html index d6710ade..33ef575a 100644 --- a/docs/reference/drug_external_links.html +++ b/docs/reference/drug_external_links.html @@ -1,75 +1,55 @@ -Drug External Links parser — drug_external_links • dbparser - - -
    -
    -
    -
    -

    Drug External Links parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug External Links parser

    + Source: R/drug_parsers.R +
    drug_external_links.Rd
    -
    +

    Links to other websites or databases providing information about this drug.

    -
    +
    +

    Usage

    drug_external_links()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    resource
    +
    +

    Value

    +

    a tibble with the following variables:

    resource

    Name of the source website.

    identifier
    @@ -81,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_external_links.md b/docs/reference/drug_external_links.md new file mode 100644 index 00000000..816c3337 --- /dev/null +++ b/docs/reference/drug_external_links.md @@ -0,0 +1,26 @@ +# Drug External Links parser + +Links to other websites or databases providing information about this +drug. + +## Usage + +``` r +drug_external_links() +``` + +## Value + +a tibble with the following variables: + +- resource: + + Name of the source website. + +- identifier: + + Identifier for this drug in the given resource + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_food_interactions.html b/docs/reference/drug_food_interactions.html index 10f4f869..6d0d1361 100644 --- a/docs/reference/drug_food_interactions.html +++ b/docs/reference/drug_food_interactions.html @@ -1,75 +1,55 @@ -Drug Groups parser — drug_food_interactions • dbparser - - -
    -
    -
    -
    -

    Drug Groups parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Groups parser

    + Source: R/drug_parsers.R +
    drug_food_interactions.Rd
    -
    +

    Food that may interact with this drug.

    -
    +
    +

    Usage

    drug_food_interactions()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    food-interaction
    +
    +

    Value

    +

    a tibble with the following variables:

    food-interaction
    drugbank_id
    @@ -78,27 +58,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_food_interactions.md b/docs/reference/drug_food_interactions.md new file mode 100644 index 00000000..ae88d237 --- /dev/null +++ b/docs/reference/drug_food_interactions.md @@ -0,0 +1,19 @@ +# Drug Groups parser + +Food that may interact with this drug. + +## Usage + +``` r +drug_food_interactions() +``` + +## Value + +a tibble with the following variables: + +- food-interaction: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_general_information.html b/docs/reference/drug_general_information.html index 1ed412aa..167f38f8 100644 --- a/docs/reference/drug_general_information.html +++ b/docs/reference/drug_general_information.html @@ -1,77 +1,58 @@ -Drugs General Information parser — drug_general_information • dbparser - - -
    -
    -
    -
    -

    Drugs General Information parser

    - Source: R/drug_main_node_parser.R - + + + +
    +
    +
    +
    +

    Drugs General Information parser

    + Source: R/drug_main_node_parser.R +
    drug_general_information.Rd
    -
    +

    A description of the hierarchical chemical classification of the drug; imported from ClassyFire.

    -
    +
    +

    Usage

    drug_general_information()
    -
    -

    Value

    - - -

    a tibble with 15 variables:

    primary_key
    +
    +

    Value

    +

    a tibble with 15 variables:

    primary_key

    DrugBank id

    other_keys
    @@ -127,27 +108,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_general_information.md b/docs/reference/drug_general_information.md new file mode 100644 index 00000000..0d36c920 --- /dev/null +++ b/docs/reference/drug_general_information.md @@ -0,0 +1,79 @@ +# Drugs General Information parser + +A description of the hierarchical chemical classification of the drug; +imported from ClassyFire. + +## Usage + +``` r +drug_general_information() +``` + +## Value + +a tibble with 15 variables: + +- primary_key: + + DrugBank id + +- other_keys: + + Other identifiers that may be associated with the drug + +- type: + + Either small molecule, or biotech. Biotech is used for any drug that + is derived from living systems or organisms, usually composed of high + molecular weight mixtures of protein, while small molecule describes a + low molecular weight organic compound. + +- name: + +- created: + + Date that this drug was first added to DrugBank. + +- updated: + + Denotes when this drug was last updated in DrugBank. + +- description: + + Descriptions of drug chemical properties, history and regulatory + status. + +- cas_number: + + The Chemical Abstracts Service (CAS) registry number assigned to the + drug. + +- *unii*: + + Unique Ingredient Identifier (UNII) of this drug. + +- average_mass: + + The weighted average of the isotopic masses of the drug + +- state: + + One of solid, liquid, or gas + +- monoisotopic_mass: + + The mass of the most abundant isotope of the drug + +- synthesis_reference: + + Citation for synthesis of the drug molecule. + +- fda_label: + + Contains a URL for accessing the uploaded United States Food and Drug + Administration (FDA) Monograph for this drug. + +- msds: + + Contains a URL for accessing the Material Safety Data Sheet (MSDS) for + this drug. diff --git a/docs/reference/drug_groups.html b/docs/reference/drug_groups.html index 32cb3c78..aff293a1 100644 --- a/docs/reference/drug_groups.html +++ b/docs/reference/drug_groups.html @@ -1,77 +1,58 @@ -Drug Groups parser — drug_groups • dbparser - - -
    -
    -
    -
    -

    Drug Groups parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Groups parser

    + Source: R/drug_parsers.R +
    drug_groups.Rd
    -
    +

    Groups that this drug belongs to. May include any of: approved, vet_approved, nutraceutical, illicit, withdrawn, investigational, and experimental.

    -
    +
    +

    Usage

    drug_groups()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    group
    +
    +

    Value

    +

    a tibble with 2 variables:

    group
    drugbank_id
    @@ -80,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_groups.md b/docs/reference/drug_groups.md new file mode 100644 index 00000000..f96a0b0b --- /dev/null +++ b/docs/reference/drug_groups.md @@ -0,0 +1,21 @@ +# Drug Groups parser + +Groups that this drug belongs to. May include any of: approved, +vet_approved, nutraceutical, illicit, withdrawn, investigational, and +experimental. + +## Usage + +``` r +drug_groups() +``` + +## Value + +a tibble with 2 variables: + +- group: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_interactions.html b/docs/reference/drug_interactions.html index a43cca8b..f2fd2c2f 100644 --- a/docs/reference/drug_interactions.html +++ b/docs/reference/drug_interactions.html @@ -1,81 +1,64 @@ -Drug Interactions parser — drug_interactions • dbparserDrug Interactions parser — drug_interactions • dbparser - - -
    -
    -
    -
    -

    Drug Interactions parser

    - Source: R/drug_parsers.R - + + + + + +
    +
    +
    +
    +

    Drug Interactions parser

    + Source: R/drug_parsers.R +
    drug_interactions.Rd
    -
    +

    Drug-drug interactions detailing drugs that, when administered concomitantly with the drug of interest, will affect its activity or result in adverse effects. These interactions may be synergistic or antagonistic depending on the physiological effects and mechanism of action of each drug.

    -
    +
    +

    Usage

    drug_interactions()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    drugbank-id
    +
    +

    Value

    +

    a tibble with the following variables:

    drugbank-id

    DrugBank ID of the interacting drug.

    name
    @@ -91,27 +74,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_interactions.md b/docs/reference/drug_interactions.md new file mode 100644 index 00000000..19175b47 --- /dev/null +++ b/docs/reference/drug_interactions.md @@ -0,0 +1,34 @@ +# Drug Interactions parser + +Drug-drug interactions detailing drugs that, when administered +concomitantly with the drug of interest, will affect its activity or +result in adverse effects. These interactions may be synergistic or +antagonistic depending on the physiological effects and mechanism of +action of each drug. + +## Usage + +``` r +drug_interactions() +``` + +## Value + +a tibble with the following variables: + +- drugbank-id : + + DrugBank ID of the interacting drug. + +- name: + + Name of the interacting drug. + +- description: + + Textual description of the physiological consequences of the drug + interaction + +- *drugbank_id*: + + parent drugbank id diff --git a/docs/reference/drug_intern_brand.html b/docs/reference/drug_intern_brand.html index a50ab701..47ea2db7 100644 --- a/docs/reference/drug_intern_brand.html +++ b/docs/reference/drug_intern_brand.html @@ -1,79 +1,61 @@ -Drug International Brands parser — drug_intern_brand • dbparserDrug International Brands parser — drug_intern_brand • dbparser - - -
    -
    -
    -
    -

    Drug International Brands parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug International Brands parser

    + Source: R/drug_parsers.R +
    drug_intern_brand.Rd
    -
    +

    The proprietary names used by the manufacturers for commercially available forms of the drug, focusing on brand names for products that are available in countries other than Canada and the Unites States.

    -
    +
    +

    Usage

    drug_intern_brand()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    brand
    +
    +

    Value

    +

    a tibble with 4 variables:

    brand

    The proprietary, well-known name for given to this drug by a manufacturer.

    @@ -86,27 +68,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_intern_brand.md b/docs/reference/drug_intern_brand.md new file mode 100644 index 00000000..8e3a403b --- /dev/null +++ b/docs/reference/drug_intern_brand.md @@ -0,0 +1,28 @@ +# Drug International Brands parser + +The proprietary names used by the manufacturers for commercially +available forms of the drug, focusing on brand names for products that +are available in countries other than Canada and the Unites States. + +## Usage + +``` r +drug_intern_brand() +``` + +## Value + +a tibble with 4 variables: + +- brand: + + The proprietary, well-known name for given to this drug by a + manufacturer. + +- company: + + The company or manufacturer that uses this name. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_manufacturers.html b/docs/reference/drug_manufacturers.html index f8627813..42e0233c 100644 --- a/docs/reference/drug_manufacturers.html +++ b/docs/reference/drug_manufacturers.html @@ -1,77 +1,58 @@ -Drug Manufacturers parser — drug_manufacturers • dbparser - - -
    -
    -
    -
    -

    Drug Manufacturers parser

    - Source: R/drug_manufacturer_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Manufacturers parser

    + Source: R/drug_manufacturer_node_parser.R +
    drug_manufacturers.Rd
    -
    +

    A list of companies that are manufacturing the commercially available forms of this drug that are available in Canada and the Unites States.

    -
    +
    +

    Usage

    drug_manufacturers()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    generic
    +
    +

    Value

    +

    a tibble with the following variables:

    generic

    A list of companies that are manufacturing the generic form of the drug.

    @@ -84,27 +65,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_manufacturers.md b/docs/reference/drug_manufacturers.md new file mode 100644 index 00000000..8f21f701 --- /dev/null +++ b/docs/reference/drug_manufacturers.md @@ -0,0 +1,27 @@ +# Drug Manufacturers parser + +A list of companies that are manufacturing the commercially available +forms of this drug that are available in Canada and the Unites States. + +## Usage + +``` r +drug_manufacturers() +``` + +## Value + +a tibble with the following variables: + +- generic: + + A list of companies that are manufacturing the generic form of the + drug. + +- url: + + A link to the companies that are manufacturing the drug. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_mixtures.html b/docs/reference/drug_mixtures.html index 3d71279e..799d09f6 100644 --- a/docs/reference/drug_mixtures.html +++ b/docs/reference/drug_mixtures.html @@ -1,77 +1,58 @@ -Drug Mixtures parser — drug_mixtures • dbparser - - -
    -
    -
    -
    -

    Drug Mixtures parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Mixtures parser

    + Source: R/drug_parsers.R +
    drug_mixtures.Rd
    -
    +

    All commercially available products in which this drug is available in combination with other drug molecules

    -
    +
    +

    Usage

    drug_mixtures()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    name
    +
    +

    Value

    +

    a tibble with 4 variables:

    name

    The proprietary name provided by the manufacturer for this combination product.

    @@ -89,27 +70,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_mixtures.md b/docs/reference/drug_mixtures.md new file mode 100644 index 00000000..9dbec08f --- /dev/null +++ b/docs/reference/drug_mixtures.md @@ -0,0 +1,33 @@ +# Drug Mixtures parser + +All commercially available products in which this drug is available in +combination with other drug molecules + +## Usage + +``` r +drug_mixtures() +``` + +## Value + +a tibble with 4 variables: + +- name: + + The proprietary name provided by the manufacturer for this combination + product. + +- ingredients: + + A list of ingredients, separated by addition symbols + +- supplemental-ingredients: + + List of additional active ingredients which are not clinically + relevant to the main indication of the product, separated by addition + symbols. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_node_options.html b/docs/reference/drug_node_options.html index 5cd6c08b..43323fd2 100644 --- a/docs/reference/drug_node_options.html +++ b/docs/reference/drug_node_options.html @@ -1,105 +1,83 @@ -returns drug node valid options. — drug_node_options • dbparser - - -
    -
    -
    -
    -

    returns drug node valid options.

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    returns drug node valid options.

    + Source: R/drugbank_parser.R +
    drug_node_options.Rd
    -
    +

    returns drug node valid options.

    -
    +
    +

    Usage

    drug_node_options()
    -
    -

    Value

    - - -

    list of drug valid options

    +
    +

    Value

    +

    list of drug valid options

    - - -
    +
    -
    + - - diff --git a/docs/reference/drug_node_options.md b/docs/reference/drug_node_options.md new file mode 100644 index 00000000..f36ddfbd --- /dev/null +++ b/docs/reference/drug_node_options.md @@ -0,0 +1,22 @@ +# returns drug node valid options. + +returns drug node valid options. + +## Usage + +``` r +drug_node_options() +``` + +## Value + +list of drug valid options + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/drug_packagers.html b/docs/reference/drug_packagers.html index 86525bca..45390bba 100644 --- a/docs/reference/drug_packagers.html +++ b/docs/reference/drug_packagers.html @@ -1,75 +1,55 @@ -Drug Packagers parser — drug_packagers • dbparser - - -
    -
    -
    -
    -

    Drug Packagers parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Packagers parser

    + Source: R/drug_parsers.R +
    drug_packagers.Rd
    -
    +

    A list of companies that are packaging the drug for re-distribution.

    -
    +
    +

    Usage

    drug_packagers()
    -
    -

    Value

    - - -

    a tibble with 2 variables:

    name
    +
    +

    Value

    +

    a tibble with 2 variables:

    name
    url
    @@ -82,27 +62,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_packagers.md b/docs/reference/drug_packagers.md new file mode 100644 index 00000000..e8bdc98c --- /dev/null +++ b/docs/reference/drug_packagers.md @@ -0,0 +1,24 @@ +# Drug Packagers parser + +A list of companies that are packaging the drug for re-distribution. + +## Usage + +``` r +drug_packagers() +``` + +## Value + +a tibble with 2 variables: + +- name: + +- url: + + A link to any companies that are packaging the drug for + re-distribution. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_patents.html b/docs/reference/drug_patents.html index 02a9baf6..7119f49a 100644 --- a/docs/reference/drug_patents.html +++ b/docs/reference/drug_patents.html @@ -1,79 +1,52 @@ -Drug Patents parser +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents • dbparser - - -
    -
    - - - -
    -
    -
    -

    Drug Patents parser -A property right issued by the United States Patent and Trademark -Office (USPTO) to an inventor for a limited time, in exchange for public -disclosure of the invention when the patent is granted. Drugs may be issued -multiple patents.

    - Source: R/drug_parsers.R - + +
    +
    +
    +

    Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents.

    + Source: R/drug_parsers.R +
    drug_patents.Rd
    -
    +

    Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public @@ -81,15 +54,14 @@

    Drug Patents parser multiple patents.

    -
    +
    +

    Usage

    drug_patents()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    number
    +
    +

    Value

    +

    a tibble with the following variables:

    number

    The patent number(s) associated with the drug.

    country
    @@ -112,27 +84,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_patents.md b/docs/reference/drug_patents.md new file mode 100644 index 00000000..9242ef07 --- /dev/null +++ b/docs/reference/drug_patents.md @@ -0,0 +1,42 @@ +# Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. + +Drug Patents parser A property right issued by the United States Patent +and Trademark Office (USPTO) to an inventor for a limited time, in +exchange for public disclosure of the invention when the patent is +granted. Drugs may be issued multiple patents. + +## Usage + +``` r +drug_patents() +``` + +## Value + +a tibble with the following variables: + +- number: + + The patent number(s) associated with the drug. + +- country: + + The country that issued the patent rights. + +- approved: + + The date that the patent request was filed. + +- expires: + + The date that the patent rights expire. + +- pediatric-extension: + + Indicates whether or not a pediatric extension has been approved for + the patent. Granted pediatric extensions provide an additional 6 + months of market protection. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_pathway.html b/docs/reference/drug_pathway.html index 09352be2..7df74e36 100644 --- a/docs/reference/drug_pathway.html +++ b/docs/reference/drug_pathway.html @@ -1,77 +1,58 @@ -Drug Pathway parser — drug_pathway • dbparser - - -
    -
    -
    -
    -

    Drug Pathway parser

    - Source: R/drug_pathway_node_parsers.R - + + + +
    +
    +
    +
    +

    Drug Pathway parser

    + Source: R/drug_pathway_node_parsers.R +
    drug_pathway.Rd
    -
    +

    Metabolic, disease, and biological pathways that the drug is involved in, as identified by the Small Molecule Protein Database (SMPDB).

    -
    +
    +

    Usage

    drug_pathway()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    smpdb-id
    +
    +

    Value

    +

    a tibble with the following variables:

    smpdb-id

    Small Molecule Pathway Database identifier for this pathway.

    @@ -87,27 +68,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pathway.md b/docs/reference/drug_pathway.md new file mode 100644 index 00000000..75b37de2 --- /dev/null +++ b/docs/reference/drug_pathway.md @@ -0,0 +1,30 @@ +# Drug Pathway parser + +Metabolic, disease, and biological pathways that the drug is involved +in, as identified by the Small Molecule Protein Database (SMPDB). + +## Usage + +``` r +drug_pathway() +``` + +## Value + +a tibble with the following variables: + +- smpdb-id: + + Small Molecule Pathway Database identifier for this pathway. + +- name: + + Pathway name + +- category: + + Pathway category + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_pathway_drugs.html b/docs/reference/drug_pathway_drugs.html index 230cae9b..84d1d9fc 100644 --- a/docs/reference/drug_pathway_drugs.html +++ b/docs/reference/drug_pathway_drugs.html @@ -1,98 +1,74 @@ -Drug Pathway Drugs parser — drug_pathway_drugs • dbparser - - -
    -
    -
    -
    -

    Drug Pathway Drugs parser

    - Source: R/drug_pathway_node_parsers.R - + + + +
    +
    +
    +
    +

    Drug Pathway Drugs parser

    + Source: R/drug_pathway_node_parsers.R +
    drug_pathway_drugs.Rd
    -
    +

    Drugs involved in this pathway.

    -
    +
    +

    Usage

    drug_pathway_drugs()
    -
    -

    Value

    - - -

    a tibble with pathway drugs properties

    +
    +

    Value

    +

    a tibble with pathway drugs properties

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pathway_drugs.md b/docs/reference/drug_pathway_drugs.md new file mode 100644 index 00000000..67a85990 --- /dev/null +++ b/docs/reference/drug_pathway_drugs.md @@ -0,0 +1,13 @@ +# Drug Pathway Drugs parser + +Drugs involved in this pathway. + +## Usage + +``` r +drug_pathway_drugs() +``` + +## Value + +a tibble with pathway drugs properties diff --git a/docs/reference/drug_pathway_enzyme.html b/docs/reference/drug_pathway_enzyme.html index c830b46c..4db3774d 100644 --- a/docs/reference/drug_pathway_enzyme.html +++ b/docs/reference/drug_pathway_enzyme.html @@ -1,98 +1,74 @@ -Drug Pathway Enzymes parser — drug_pathway_enzyme • dbparser - - -
    -
    -
    -
    -

    Drug Pathway Enzymes parser

    - Source: R/drug_pathway_node_parsers.R - + + + +
    +
    +
    +
    +

    Drug Pathway Enzymes parser

    + Source: R/drug_pathway_node_parsers.R +
    drug_pathway_enzyme.Rd
    -
    +

    Enzymes involved in this pathway.

    -
    +
    +

    Usage

    drug_pathway_enzyme()
    -
    -

    Value

    - - -

    a tibble with pathway properties

    +
    +

    Value

    +

    a tibble with pathway properties

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pathway_enzyme.md b/docs/reference/drug_pathway_enzyme.md new file mode 100644 index 00000000..38f91d8a --- /dev/null +++ b/docs/reference/drug_pathway_enzyme.md @@ -0,0 +1,13 @@ +# Drug Pathway Enzymes parser + +Enzymes involved in this pathway. + +## Usage + +``` r +drug_pathway_enzyme() +``` + +## Value + +a tibble with pathway properties diff --git a/docs/reference/drug_pdb_entries.html b/docs/reference/drug_pdb_entries.html index 21f2ec6a..d1864db5 100644 --- a/docs/reference/drug_pdb_entries.html +++ b/docs/reference/drug_pdb_entries.html @@ -1,75 +1,55 @@ -Drug pdb-entries parser — drug_pdb_entries • dbparser - - -
    -
    -
    -
    -

    Drug pdb-entries parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug pdb-entries parser

    + Source: R/drug_parsers.R +
    drug_pdb_entries.Rd
    -
    +

    Protein Data Bank (PDB) identifiers for this drug.

    -
    +
    +

    Usage

    drug_pdb_entries()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    pdb-entry
    +
    +

    Value

    +

    a tibble with the following variables:

    pdb-entry
    drugbank_id
    @@ -78,27 +58,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pdb_entries.md b/docs/reference/drug_pdb_entries.md new file mode 100644 index 00000000..4d5abbf9 --- /dev/null +++ b/docs/reference/drug_pdb_entries.md @@ -0,0 +1,19 @@ +# Drug pdb-entries parser + +Protein Data Bank (PDB) identifiers for this drug. + +## Usage + +``` r +drug_pdb_entries() +``` + +## Value + +a tibble with the following variables: + +- pdb-entry: + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_pharmacology.html b/docs/reference/drug_pharmacology.html index 87f85963..3f5a8eaf 100644 --- a/docs/reference/drug_pharmacology.html +++ b/docs/reference/drug_pharmacology.html @@ -1,77 +1,58 @@ -Drug Pharmacology parser — drug_pharmacology • dbparser - - -
    -
    -
    -
    -

    Drug Pharmacology parser

    - Source: R/drug_pharmacology_parser.R - + + + +
    +
    +
    +
    +

    Drug Pharmacology parser

    + Source: R/drug_pharmacology_parser.R +
    drug_pharmacology.Rd
    -
    +

    Describes the use, mechanism of action, pharmacokinetics, pharmacodynamics, and physiological or biochemical effects in the body.

    -
    +
    +

    Usage

    drug_pharmacology()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    indication
    +
    +

    Value

    +

    a tibble with the following variables:

    indication

    The approved conditions, diseases, or states for which a drug can safely and effectively be used. An indication is considered to be FDA-approved when it has any of the following designations: NDA, ANDA, BLA, @@ -142,27 +123,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_pharmacology.md b/docs/reference/drug_pharmacology.md new file mode 100644 index 00000000..be4e1ca7 --- /dev/null +++ b/docs/reference/drug_pharmacology.md @@ -0,0 +1,94 @@ +# Drug Pharmacology parser + +Describes the use, mechanism of action, pharmacokinetics, +pharmacodynamics, and physiological or biochemical effects in the body. + +## Usage + +``` r +drug_pharmacology() +``` + +## Value + +a tibble with the following variables: + +- indication: + + The approved conditions, diseases, or states for which a drug can + safely and effectively be used. An indication is considered to be + FDA-approved when it has any of the following designations: NDA, ANDA, + BLA, or OTC. May also include indications in other countries, such as + Canada (through Health Canada) or in Europe (through the European + Medicines Agency). + +- pharmacodynamics: + + A description of how the drug modifies or affects the organism it is + being used in. May include effects in the body that are desired + (enzyme or protein targets for example) and undesired (also known as + “side effects”). This is in contrast to pharmacokinetics, which + describes how the body modifies the drug being used. + +- mechanism_of_action: + + A component of pharmacodynamics that describes the biochemical + interaction through which a drug produces its intended effect. May + include the exact molecular protein or enzyme targets and/or a + description of the physiological effects produced. + +- toxicity: + + Any adverse reaction, or side effect, that may or may not occur with + use of the drug. May be attributed to a number of effects including: + an enhanced therapeutic effect, rare anaphylactic reactions, + interactions with other medications, or unanticipated binding of the + molecule at different sites within the body. + +- metabolism: + + A description of the chemical degradation of the drug molecule within + the body; most commonly by enzymes from the Cytochrome P450 (CYP) + system in the liver. + +- absorption: + + A description of the movement of the drug from the site of + administration into the bloodstream or target tissue. Common + pharmacokinetic metrics used to evaluate absorption include Area Under + the Curve (AUC), bioavailability (F), maximum concentration (Cmax), + and time to maximum concentration (Tmax). + +- half-life: + + The period of time it takes for the amount of drug in the body to be + reduced by one half. Provides a description of how quickly the drug is + being eliminated and how much is available in the bloodstream. + +- protein-binding : + + A description of the drug’s affinity for plama proteins and the + proportion of the drug that is bound to them when in circulation + within the body. + +- route_of_elimination: + + A description of the pathway that is used to excrete the drug from the + body. Common pharmacokinetic parameters used to evaluate excretion + include elimination half life, renal clearance, and tracking of + radiolabelled compounds through the renal and GI system. + +- volume_of_distribution: + + The Vd of a drug represents the degree to which it is distributed into + body tissue compared to the plasma. + +- clearance: + + A pharmacokinetic measurement of the rate of removal of the drug from + plasma, expressed as mL/min; reflects the rate of elimination of the + drug. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_prices.html b/docs/reference/drug_prices.html index efcdba6e..bd179c40 100644 --- a/docs/reference/drug_prices.html +++ b/docs/reference/drug_prices.html @@ -1,75 +1,55 @@ -Drug Prices Parsers — drug_prices • dbparser - - -
    -
    -
    -
    -

    Drug Prices Parsers

    - Source: R/drug_price_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Prices Parsers

    + Source: R/drug_price_node_parser.R +
    drug_prices.Rd
    -
    +

    Unit drug prices

    -
    +
    +

    Usage

    drug_prices()
    -
    -

    Value

    - - -

    a tibble with 5 variables:

    description
    +
    +

    Value

    +

    a tibble with 5 variables:

    description
    cost
    @@ -87,27 +67,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_prices.md b/docs/reference/drug_prices.md new file mode 100644 index 00000000..e762aab4 --- /dev/null +++ b/docs/reference/drug_prices.md @@ -0,0 +1,29 @@ +# Drug Prices Parsers + +Unit drug prices + +## Usage + +``` r +drug_prices() +``` + +## Value + +a tibble with 5 variables: + +- description: + +- cost: + + Drug price per unit + +- currency: + + Currency of price, example: US. + +- unit: + +- parent_id: + + drugbank id diff --git a/docs/reference/drug_products.html b/docs/reference/drug_products.html index f74d2784..bcda7582 100644 --- a/docs/reference/drug_products.html +++ b/docs/reference/drug_products.html @@ -1,77 +1,58 @@ -Drug Products parser — drug_products • dbparser - - -
    -
    -
    -
    -

    Drug Products parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Products parser

    + Source: R/drug_parsers.R +
    drug_products.Rd
    -
    +

    A list of commercially available products in Canada and the United States that contain the drug.

    -
    +
    +

    Usage

    drug_products()
    -
    -

    Value

    - - -

    a tibble with 32 variables:

    name
    +
    +

    Value

    +

    a tibble with 32 variables:

    name

    The proprietary name(s) provided by the manufacturer for any commercially available products containing this drug.

    @@ -191,27 +172,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_products.md b/docs/reference/drug_products.md new file mode 100644 index 00000000..f7740365 --- /dev/null +++ b/docs/reference/drug_products.md @@ -0,0 +1,159 @@ +# Drug Products parser + +A list of commercially available products in Canada and the United +States that contain the drug. + +## Usage + +``` r +drug_products() +``` + +## Value + +a tibble with 32 variables: + +- name: + + The proprietary name(s) provided by the manufacturer for any + commercially available products containing this drug. + +- labeller: + + The corporation responsible for labelling this product. + +- ndc-id: + + The National Drug Code (NDC) identifier of the drug + +- ndc-product-code: + + The National Drug Code (NDC) product code from the FDA National Drug + Code directory. + +- dpd-id: + + Drug Product Database (DPD) identification number (a.k.a. DIN) from + the Canadian Drug Product Database. Only present for drugs that are + marketed in Canada + +- ema-product-code: + + EMA product code from the European Medicines Agency Database. Only + present for products that are authorized by central procedure for + marketing in the European Union. + +- ema-ma-number: + + EMA marketing authorization number from the European Medicines Agency + Database. Only present for products that are authorized by central + procedure for marketing in the European Union. + +- started-marketing-on: + + The starting date for market approval. + +- ended-marketing-on: + + The ending date for market approval. + +- dosage-form : + + The pharmaceutical formulation by which the drug is introduced into + the body. + +- strength: + + The amount of active drug ingredient provided in the dosage + +- route: + + The path by which the drug or product is taken into the body + +- fda-application-number: + + The New Drug Application \[NDA\] number assigned to this drug by the + FDA. + +- over-the-counter: + + A list of Over The Counter (OTC) forms of the drug. + +- generic: + + Whether this product is a generic drug. + +- approved: + + Indicates whether this drug has been approved by the regulating + government. + +- country: + + The country where this commercially available drug has been approved. + +- source: + + Source of this product information. For example, a value of DPD + indicates this information was retrieved from the Canadian Drug + Product Database. + +- standing: + + One of good, discordant, or deprecated. Distinguishes products with up + to date ingredient information (good) from products with conflicting + information (discordant) or products that have been removed from an + active label (deprecated). + +- standing-updated-on: + + The date on which the standing was last updated + +- standing-reason: + + Explains the non-good standing of the product. One of: + ingredient_change, code_duplication, invalid, or removed. + +- jurisdiction-marketing-category : + + The marketing category of this product in its jurisdiction + +- branded: + + Whether this product has a named brand + +- prescription: + + Whether this product is only available with a prescription + +- unapproved: + + Whether this product is not approved in its jurisdiction + +- vaccine: + + Whether this product is a vaccine + +- allergenic: + + Whether this product is used in allergenic testing + +- cosmetic: + + Whether this product is a cosmetic, such as sunscreen + +- kit: + + Whether this product is a kit composed of multiple distinct parts + +- solo: + + Whether this product has only a single active ingredient + +- available: + + Whether this product can be sold in its jurisdiction + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_reactions.html b/docs/reference/drug_reactions.html index 3f28b5d5..f5a54066 100644 --- a/docs/reference/drug_reactions.html +++ b/docs/reference/drug_reactions.html @@ -1,67 +1,52 @@ -Drug Reactions Parsers — drug_reactions • dbparserDrug Reactions Parsers — drug_reactions • dbparser - - -
    -
    -
    -
    -

    Drug Reactions Parsers

    - Source: R/drug_reaction_node_parser.R - + + + + + +
    +
    +
    +
    +

    Drug Reactions Parsers

    + Source: R/drug_reaction_node_parser.R +
    drug_reactions.Rd
    -
    +

    Extract the sequential representation of the metabolic reactions that this drug molecule is involved in. Depending on available information, this may include metabolizing enzymes, reaction type, substrates, products, @@ -69,15 +54,14 @@

    Drug Reactions Parsers

    the biochemical reactions.

    -
    +
    +

    Usage

    drug_reactions()
    -
    -

    Value

    - - -

    a tibble with 5 variables:

    sequence
    +
    +

    Value

    +

    a tibble with 5 variables:

    sequence

    Reactions are displayed within a numerical sequence

    left_drugbank_name
    @@ -100,27 +84,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_reactions.md b/docs/reference/drug_reactions.md new file mode 100644 index 00000000..bf2a4ed4 --- /dev/null +++ b/docs/reference/drug_reactions.md @@ -0,0 +1,37 @@ +# Drug Reactions Parsers + +Extract the sequential representation of the metabolic reactions that +this drug molecule is involved in. Depending on available information, +this may include metabolizing enzymes, reaction type, substrates, +products, pharmacological activity of metabolites, and a structural +representation of the biochemical reactions. + +## Usage + +``` r +drug_reactions() +``` + +## Value + +a tibble with 5 variables: + +- sequence: + + Reactions are displayed within a numerical sequence + +- left_drugbank_name: + + The substrate of the reaction. Maybe a drug or a metabolite. + +- rightt_drugbank_name: + + The product of the reaction. Maybe a drug or a metabolite. + +- left_drugbank_id: + +- right_drugbank_id: + +- parent_id: + + drugbank id diff --git a/docs/reference/drug_reactions_enzymes.html b/docs/reference/drug_reactions_enzymes.html index af6fda53..17144056 100644 --- a/docs/reference/drug_reactions_enzymes.html +++ b/docs/reference/drug_reactions_enzymes.html @@ -1,75 +1,55 @@ -Drug Reactions Enzymes Parsers — drug_reactions_enzymes • dbparser - - -
    -
    -
    -
    -

    Drug Reactions Enzymes Parsers

    - Source: R/drug_reaction_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Reactions Enzymes Parsers

    + Source: R/drug_reaction_node_parser.R +
    drug_reactions_enzymes.Rd
    -
    +

    Enzymes involved in metabolizing this drug

    -
    +
    +

    Usage

    drug_reactions_enzymes()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    name
    +
    +

    Value

    +

    a tibble with 3 variables:

    name
    uniprot-id
    @@ -81,27 +61,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_reactions_enzymes.md b/docs/reference/drug_reactions_enzymes.md new file mode 100644 index 00000000..24ffe0dd --- /dev/null +++ b/docs/reference/drug_reactions_enzymes.md @@ -0,0 +1,21 @@ +# Drug Reactions Enzymes Parsers + +Enzymes involved in metabolizing this drug + +## Usage + +``` r +drug_reactions_enzymes() +``` + +## Value + +a tibble with 3 variables: + +- name: + +- uniprot-id: + +- parent_id: + + drugbank id diff --git a/docs/reference/drug_salts.html b/docs/reference/drug_salts.html index 5ebe6e8a..b42d1768 100644 --- a/docs/reference/drug_salts.html +++ b/docs/reference/drug_salts.html @@ -1,79 +1,61 @@ -Drug Salts parser — drug_salts • dbparserDrug Salts parser — drug_salts • dbparser - - -
    -
    -
    -
    -

    Drug Salts parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug Salts parser

    + Source: R/drug_parsers.R +
    drug_salts.Rd
    -
    +

    Available salt forms of the drug. Ions such as hydrochloride, sodium, and sulfate are often added to the drug molecule to increase solubility, dissolution, or absorption.

    -
    +
    +

    Usage

    drug_salts()
    -
    -

    Value

    - - -

    a tibble with 1 variables:

    drugbank-id
    +
    +

    Value

    +

    a tibble with 1 variables:

    drugbank-id

    DrugBank identifiers of the available salt form(s).

    name
    @@ -117,27 +99,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_salts.md b/docs/reference/drug_salts.md new file mode 100644 index 00000000..36921cd8 --- /dev/null +++ b/docs/reference/drug_salts.md @@ -0,0 +1,66 @@ +# Drug Salts parser + +Available salt forms of the drug. Ions such as hydrochloride, sodium, +and sulfate are often added to the drug molecule to increase solubility, +dissolution, or absorption. + +## Usage + +``` r +drug_salts() +``` + +## Value + +a tibble with 1 variables: + +- drugbank-id: + + DrugBank identifiers of the available salt form(s). + +- name: + + Name of the available salt form(s) + +- unii: + + Unique Ingredient Identifier (UNII) of the available salt form(s). + +- cas-number: + + Chemical Abstracts Service (CAS) registry number assigned to the salt + form(s) of the drug. + +- inchikey: + + IUPAC International Chemical Identifier (InChi) key identifier for the + available salt form(s). + +- average-mass: + + Average molecular mass: the weighted average of the isotopic masses of + the salt. + +- monoisotopic-mass: + + The mass of the most abundant isotope of the salt + +- smiles: + + The simplified molecular-input line-entry system (SMILES) is a line + notation used for describing the structure of chemical species using + short ASCII strings; calculated by ChemAxon. + +- inchi: + + A prediction of the IUPAC International Chemical Identifier (InChI); + imported by ChemAxon. + +- formula: + + Indicates the simple numbers of each type of atom within the molecule; + calculated by ChemAxon. + +- *drugbank_id*: + + parent drugbank id diff --git a/docs/reference/drug_sequences.html b/docs/reference/drug_sequences.html index f78cf0b7..ddd32023 100644 --- a/docs/reference/drug_sequences.html +++ b/docs/reference/drug_sequences.html @@ -1,75 +1,55 @@ -Drug Sequences parser — drug_sequences • dbparser - - -
    -
    -
    -
    -

    Drug Sequences parser

    - Source: R/drug_sequence_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Sequences parser

    + Source: R/drug_sequence_node_parser.R +
    drug_sequences.Rd
    -
    +

    The amino acid sequence; provided if the drug is a peptide.

    -
    +
    +

    Usage

    drug_sequences()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    sequence
    +
    +

    Value

    +

    a tibble with the following variables:

    sequence

    a textual representation of the sequence

    format
    @@ -80,32 +60,28 @@

    Value

    -
    -

    Details

    +
    +

    Details

    Describes peptide sequences of biotech drugs

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_sequences.md b/docs/reference/drug_sequences.md new file mode 100644 index 00000000..69ea7300 --- /dev/null +++ b/docs/reference/drug_sequences.md @@ -0,0 +1,29 @@ +# Drug Sequences parser + +The amino acid sequence; provided if the drug is a peptide. + +## Usage + +``` r +drug_sequences() +``` + +## Value + +a tibble with the following variables: + +- sequence: + + a textual representation of the sequence + +- format: + + Currently, only the FASTA format is used + +- *drugbank_id*: + + drugbank id + +## Details + +Describes peptide sequences of biotech drugs diff --git a/docs/reference/drug_snp_adverse_reactions.html b/docs/reference/drug_snp_adverse_reactions.html index 2e947011..1f8b6945 100644 --- a/docs/reference/drug_snp_adverse_reactions.html +++ b/docs/reference/drug_snp_adverse_reactions.html @@ -1,77 +1,58 @@ -Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions • dbparser - - -
    -
    -
    -
    -

    Drug SNP Adverse Drug Reactions parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug SNP Adverse Drug Reactions parser

    + Source: R/drug_parsers.R +
    drug_snp_adverse_reactions.Rd
    -
    +

    The adverse drug reactions that may occur as a result of the listed single nucleotide polymorphisms (SNPs)

    -
    +
    +

    Usage

    drug_snp_adverse_reactions()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    protein-name
    +
    +

    Value

    +

    a tibble with the following variables:

    protein-name

    Proteins involved in this SNP.

    gene-symbol
    @@ -103,27 +84,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_snp_adverse_reactions.md b/docs/reference/drug_snp_adverse_reactions.md new file mode 100644 index 00000000..0072815f --- /dev/null +++ b/docs/reference/drug_snp_adverse_reactions.md @@ -0,0 +1,47 @@ +# Drug SNP Adverse Drug Reactions parser + +The adverse drug reactions that may occur as a result of the listed +single nucleotide polymorphisms (SNPs) + +## Usage + +``` r +drug_snp_adverse_reactions() +``` + +## Value + +a tibble with the following variables: + +- protein-name: + + Proteins involved in this SNP. + +- gene-symbol: + + Genes involved in this SNP. + +- uniprot-id: + + Universal Protein Resource (UniProt) identifiers for proteins involved + in this pathway. + +- rs-id: + + The SNP Database identifier for this single nucleotide polymorphism. + +- allele: + + The alleles associated with the identified SNP. + +- adverse-reaction: + +- description: + +- pubmed-id : + + Reference to PubMed article. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_snp_effects.html b/docs/reference/drug_snp_effects.html index 2f862f5c..40695484 100644 --- a/docs/reference/drug_snp_effects.html +++ b/docs/reference/drug_snp_effects.html @@ -1,79 +1,61 @@ -Drug SNP Effects parser — drug_snp_effects • dbparserDrug SNP Effects parser — drug_snp_effects • dbparser - - -
    -
    -
    -
    -

    Drug SNP Effects parser

    - Source: R/drug_parsers.R - + + + +
    +
    +
    +
    +

    Drug SNP Effects parser

    + Source: R/drug_parsers.R +
    drug_snp_effects.Rd
    -
    +

    A list of single nucleotide polymorphisms (SNPs) relevant to drug activity or metabolism, and the effects these may have on pharmacological activity. SNP effects in the patient may require close monitoring, an increase or

    -
    +
    +

    Usage

    drug_snp_effects()
    -
    -

    Value

    - - -

    a tibble with the following variables:

    protein-name
    +
    +

    Value

    +

    a tibble with the following variables:

    protein-name

    Proteins involved in this SNP.

    gene-symbol
    @@ -105,27 +87,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_snp_effects.md b/docs/reference/drug_snp_effects.md new file mode 100644 index 00000000..158cf0f4 --- /dev/null +++ b/docs/reference/drug_snp_effects.md @@ -0,0 +1,51 @@ +# Drug SNP Effects parser + +A list of single nucleotide polymorphisms (SNPs) relevant to drug +activity or metabolism, and the effects these may have on +pharmacological activity. SNP effects in the patient may require close +monitoring, an increase or + +## Usage + +``` r +drug_snp_effects() +``` + +## Value + +a tibble with the following variables: + +- protein-name: + + Proteins involved in this SNP. + +- gene-symbol: + + Genes involved in this SNP. + +- uniprot-id: + + Universal Protein Resource (UniProt) identifiers for proteins involved + in this pathway. + +- rs-id: + + The SNP Database identifier for this single nucleotide polymorphism. + +- allele: + + The alleles associated with the identified SNP. + +- defining-change: + +- description: + + A written description of the SNP effects. + +- pubmed-id : + + Reference to PubMed article. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drug_syn.html b/docs/reference/drug_syn.html index 652548b1..111504b9 100644 --- a/docs/reference/drug_syn.html +++ b/docs/reference/drug_syn.html @@ -1,75 +1,55 @@ -Drug Synonyms parser — drug_syn • dbparser - - -
    -
    -
    -
    -

    Drug Synonyms parser

    - Source: R/drug_synonym_node_parser.R - + + + +
    +
    +
    +
    +

    Drug Synonyms parser

    + Source: R/drug_synonym_node_parser.R +
    drug_syn.Rd
    -
    +

    Other names or identifiers that are associated with this drug.

    -
    +
    +

    Usage

    drug_syn()
    -
    -

    Value

    - - -

    a tibble with 3 variables:

    language
    +
    +

    Value

    +

    a tibble with 3 variables:

    language

    Names of the drug in languages other than English.

    coder
    @@ -84,27 +64,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/drug_syn.md b/docs/reference/drug_syn.md new file mode 100644 index 00000000..3016577e --- /dev/null +++ b/docs/reference/drug_syn.md @@ -0,0 +1,28 @@ +# Drug Synonyms parser + +Other names or identifiers that are associated with this drug. + +## Usage + +``` r +drug_syn() +``` + +## Value + +a tibble with 3 variables: + +- language: + + Names of the drug in languages other than English. + +- coder: + + Organization or source providing the synonym. For example, INN + indicates the synonym is an International Nonproprietary Name, while + IUPAC indicates the synonym is the nomenclature designated by the + International Union of Pure and Applied Chemistry. + +- *drugbank_id*: + + drugbank id diff --git a/docs/reference/drugs_articles.html b/docs/reference/drugs_articles.html new file mode 100644 index 00000000..b95e027f --- /dev/null +++ b/docs/reference/drugs_articles.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/drugs_attachments.html b/docs/reference/drugs_attachments.html new file mode 100644 index 00000000..2066a855 --- /dev/null +++ b/docs/reference/drugs_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/drugs_links.html b/docs/reference/drugs_links.html new file mode 100644 index 00000000..b768dff2 --- /dev/null +++ b/docs/reference/drugs_links.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/drugs_textbooks.html b/docs/reference/drugs_textbooks.html new file mode 100644 index 00000000..088dfbad --- /dev/null +++ b/docs/reference/drugs_textbooks.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes.html b/docs/reference/enzymes.html index 21723982..c4ba25d7 100644 --- a/docs/reference/enzymes.html +++ b/docs/reference/enzymes.html @@ -1,261 +1,8 @@ - - - + - - - - -Extracts the drug enzymes element and return data as tibble. — enzymes • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes returns tibble of drug enzymes elements.

    -
    - - 
    enzymes(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_articles(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes()
-
-# will throw an error, as database_connection is NULL
-enzymes(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes(save_table = TRUE, save_csv = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_actions.html b/docs/reference/enzymes_actions.html index 957afc55..49c4d12f 100644 --- a/docs/reference/enzymes_actions.html +++ b/docs/reference/enzymes_actions.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug enzymes actions element and return data as tibble. — enzymes_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes actions element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_actions returns tibble of drug enzymes -actions elements.

    -
    - - 
    enzymes_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes actions node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes actions element of drug node in - DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_articles(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_actions()
-
-# will throw an error, as database_connection is NULL
-enzymes_actions(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes_actions(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_actions(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_actions(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_articles.html b/docs/reference/enzymes_articles.html index 6c74714d..b95e027f 100644 --- a/docs/reference/enzymes_articles.html +++ b/docs/reference/enzymes_articles.html @@ -1,267 +1,8 @@ - - - + - - - - -Extracts the drug enzymes articles element and return data as tibble. — enzymes_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes articles element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_articles returns tibble of drug enzymes -articles elements.

    -
    - - 
    enzymes_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true -in the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes articles node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes articles element of drug node in drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_articles()
-
-# will throw an error, as database_connection is NULL
-enzymes_articles(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes_articles(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_articles(save_table = TRUE, save_csv = TRUE,
- database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_attachments.html b/docs/reference/enzymes_attachments.html new file mode 100644 index 00000000..2066a855 --- /dev/null +++ b/docs/reference/enzymes_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_links.html b/docs/reference/enzymes_links.html index 08b52cc3..b768dff2 100644 --- a/docs/reference/enzymes_links.html +++ b/docs/reference/enzymes_links.html @@ -1,261 +1,8 @@ - - - + - - - - -Extracts the drug enzymes links element and return data as tibble. — enzymes_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes links element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_links returns tibble of drug enzymes links -elements.

    -
    - - 
    enzymes_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes links node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes links element of drug node in -DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_articles(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes_textbooks(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_links()
-
-# will throw an error, as database_connection is NULL
-enzymes_links(save_table = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_links(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_links(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/enzymes_polypep_ex_ident.html b/docs/reference/enzymes_polypep_ex_ident.html new file mode 100644 index 00000000..7fd02f47 --- /dev/null +++ b/docs/reference/enzymes_polypep_ex_ident.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides.html b/docs/reference/enzymes_polypeptides.html new file mode 100644 index 00000000..554cbd6b --- /dev/null +++ b/docs/reference/enzymes_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides_go.html b/docs/reference/enzymes_polypeptides_go.html new file mode 100644 index 00000000..bda310f8 --- /dev/null +++ b/docs/reference/enzymes_polypeptides_go.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides_pfams.html b/docs/reference/enzymes_polypeptides_pfams.html new file mode 100644 index 00000000..cac389d9 --- /dev/null +++ b/docs/reference/enzymes_polypeptides_pfams.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_polypeptides_syn.html b/docs/reference/enzymes_polypeptides_syn.html new file mode 100644 index 00000000..c0f768c9 --- /dev/null +++ b/docs/reference/enzymes_polypeptides_syn.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/enzymes_textbooks.html b/docs/reference/enzymes_textbooks.html index b6ded567..088dfbad 100644 --- a/docs/reference/enzymes_textbooks.html +++ b/docs/reference/enzymes_textbooks.html @@ -1,268 +1,8 @@ - - - + - - - - -Extracts the drug enzymes textbooks element and return data as tibble. — enzymes_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug enzymes textbooks element and return data as tibble.

    - Source: R/drug_enzyme_node_parser.R - -
    - -
    -

    enzymes_textbooks returns tibble of drug enzymes -textbooks elements.

    -
    - - 
    enzymes_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug enzymes textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the enzymes textbooks element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other enzymes: -enzymes_actions(), -enzymes_articles(), -enzymes_links(), -enzymes_polypeptide_ext_ident(), -enzymes_polypeptide_go(), -enzymes_polypeptide_pfams(), -enzymes_polypeptide_syn(), -enzymes_polypeptide(), -enzymes()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-enzymes_textbooks()
-
-# will throw an error, as database_connection is NULL
-enzymes_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-enzymes_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_textbooks(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-enzymes_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-enzymes_textbooks(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/find_dataframes_recursive.html b/docs/reference/find_dataframes_recursive.html new file mode 100644 index 00000000..8b2b2c65 --- /dev/null +++ b/docs/reference/find_dataframes_recursive.html @@ -0,0 +1,86 @@ + +Find All Data Frames Recursively — find_dataframes_recursive • dbparser + Skip to contents + + +
    +
    +
    +

    Find All Data Frames Recursively

    + Source: R/dvobject_metadata.R +
    find_dataframes_recursive.Rd
    +
    + +
    +

    Find All Data Frames Recursively

    +
    + +
    +

    Usage

    + 
    find_dataframes_recursive(x, prefix = "")
    +
    + +
    +

    Arguments

    + + +
    x
    +

    Object to search

    + + +
    prefix
    +

    Current path prefix

    + +
    +
    +

    Value

    +

    Data.frame with paths, dimensions, and sizes

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/find_dataframes_recursive.md b/docs/reference/find_dataframes_recursive.md new file mode 100644 index 00000000..fac0d560 --- /dev/null +++ b/docs/reference/find_dataframes_recursive.md @@ -0,0 +1,23 @@ +# Find All Data Frames Recursively + +Find All Data Frames Recursively + +## Usage + +``` r +find_dataframes_recursive(x, prefix = "") +``` + +## Arguments + +- x: + + Object to search + +- prefix: + + Current path prefix + +## Value + +Data.frame with paths, dimensions, and sizes diff --git a/docs/reference/find_second_database.html b/docs/reference/find_second_database.html new file mode 100644 index 00000000..66a62317 --- /dev/null +++ b/docs/reference/find_second_database.html @@ -0,0 +1,82 @@ + +Find Second Database in Attributes — find_second_database • dbparser + Skip to contents + + +
    +
    +
    +

    Find Second Database in Attributes

    + Source: R/dvobject_metadata.R +
    find_second_database.Rd
    +
    + +
    +

    Find Second Database in Attributes

    +
    + +
    +

    Usage

    + 
    find_second_database(attrs)
    +
    + +
    +

    Arguments

    + + +
    attrs
    +

    Attributes list

    + +
    +
    +

    Value

    +

    List with has_second_db (logical) and second_db_name (character)

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/find_second_database.md b/docs/reference/find_second_database.md new file mode 100644 index 00000000..5609df02 --- /dev/null +++ b/docs/reference/find_second_database.md @@ -0,0 +1,19 @@ +# Find Second Database in Attributes + +Find Second Database in Attributes + +## Usage + +``` r +find_second_database(attrs) +``` + +## Arguments + +- attrs: + + Attributes list + +## Value + +List with has_second_db (logical) and second_db_name (character) diff --git a/docs/reference/index.html b/docs/reference/index.html index d48705b2..16dd1205 100644 --- a/docs/reference/index.html +++ b/docs/reference/index.html @@ -1,111 +1,170 @@ -Function reference • dbparser - - -
    -
    -
    -
    -

    Reference

    + +
    +
    +
    +
    +

    Package index

    - - - - - - - - - - - - -
    -

    Drugs Databases Parser

    -

    Parse public drug databases and converted them into dvobject

    -
    -

    cett_nodes_options()

    -

    returns carriers, enzymes,targets and transporters node valid options.

    -

    drug_node_options()

    -

    returns drug node valid options.

    -

    parseDrugBank()

    -

    parseDrugBank

    -

    references_node_options()

    -

    returns references node valid options.

    -

    Utility functions

    -

    Different functions to handle dvobject

    -
    -

    show_dvobject_metadata()

    -

    init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes

    - - -
    +
    +

    Drugs Databases Parser

    + +

    Parse public drug databases and converted them into dvobject

    + +
    + + + + +
    + + cett_nodes_options() + +
    +
    returns carriers, enzymes,targets and transporters node valid options.
    + +
    + + drug_node_options() + +
    +
    returns drug node valid options.
    + +
    + + parseDrugBank() + +
    +
    parseDrugBank
    + +
    + + parseOnSIDES() + +
    +
    Parse the OnSIDES Core Relational Database
    + +
    + + parseTWOSIDES() + +
    +
    Parse the TWOSIDES Drug-Drug Interaction Database
    + +
    + references_node_options() -
    +
    returns references node valid options.
    +
    +

    Utility functions

    + +

    Different functions to handle dvobject

    + +
    + + + + +
    + + add_database_info() + +
    +
    add_database_info Assign passed databases db metadata to passed dvobject
    + +
    + + show_dvobject_metadata() + +
    +
    Display dvobject Metadata
    + +
    + + subset_drugbank_dvobject() + +
    +
    Subset a DrugBank dvobject by a vector of DrugBank IDs
    + +
    + + subset_onsides_dvobject() + +
    +
    Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware)
    +
    +

    Merge functions

    + +

    Different functions to merge different types of dvobjects

    + +
    + + + + +
    + + merge_drugbank_onsides() + +
    +
    Merge DrugBank and OnSIDES Database Objects
    + +
    + + merge_drugbank_twosides() + +
    +
    Merge a DrugBank dvobject with a TWOSIDES dvobject
    +
    +
    + + +
    +
    + - - diff --git a/docs/reference/index.md b/docs/reference/index.md new file mode 100644 index 00000000..fc0592de --- /dev/null +++ b/docs/reference/index.md @@ -0,0 +1,43 @@ +# Package index + +## Drugs Databases Parser + +Parse public drug databases and converted them into dvobject + +- [`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md) + : returns carriers, enzymes,targets and transporters node valid + options. +- [`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md) + : returns drug node valid options. +- [`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md) + : parseDrugBank +- [`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md) + : Parse the OnSIDES Core Relational Database +- [`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) + : Parse the TWOSIDES Drug-Drug Interaction Database +- [`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) + : returns references node valid options. + +## Utility functions + +Different functions to handle dvobject + +- [`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md) + : add_database_info Assign passed databases db metadata to passed + dvobject +- [`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md) + : Display dvobject Metadata +- [`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md) + : Subset a DrugBank dvobject by a vector of DrugBank IDs +- [`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) + : Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs + (Schema-Aware) + +## Merge functions + +Different functions to merge different types of dvobjects + +- [`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md) + : Merge DrugBank and OnSIDES Database Objects +- [`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md) + : Merge a DrugBank dvobject with a TWOSIDES dvobject diff --git a/docs/reference/init_dvobject.html b/docs/reference/init_dvobject.html index 3ef7a07e..2cf1be24 100644 --- a/docs/reference/init_dvobject.html +++ b/docs/reference/init_dvobject.html @@ -1,103 +1,77 @@ -init_dvobject - initialize dvobject — init_dvobject • dbparser - - -
    -
    -
    -
    -

    init_dvobject - initialize dvobject

    - Source: R/dvobject_metadata.R - + + + +
    +
    +
    +
    +

    init_dvobject initialize dvobject

    + Source: R/dvobject_metadata.R +
    init_dvobject.Rd
    -
    +

    init_dvobject initialize dvobject

    -
    +
    +

    Usage

    init_dvobject()
    -
    -

    Value

    - - -

    dvobject

    +
    +

    Value

    +

    dvobject

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/init_dvobject.md b/docs/reference/init_dvobject.md new file mode 100644 index 00000000..c588412e --- /dev/null +++ b/docs/reference/init_dvobject.md @@ -0,0 +1,13 @@ +# init_dvobject initialize dvobject + +init_dvobject initialize dvobject + +## Usage + +``` r +init_dvobject() +``` + +## Value + +dvobject diff --git a/docs/reference/links.html b/docs/reference/links.html index 2cbfc56b..e8c19004 100644 --- a/docs/reference/links.html +++ b/docs/reference/links.html @@ -1,69 +1,52 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser

    - Source: R/references_parsers.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser

    + Source: R/references_parsers.R +
    links.Rd
    -
    +

    Return a list of websites that were used as references for Drugs/ Carriers/ Enzymes/ Targets/ Transporters

    -
    +
    +

    Usage

    drugs_links()
 
 carriers_links()
@@ -75,11 +58,9 @@ 
    Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser
    
 transporters_links()
    -
    -

    Value

    - - -

    a tibble with 4 variables:

    ref-id
    +
    +

    Value

    +

    a tibble with 4 variables:

    ref-id

    Name of the source website

    title
    @@ -94,27 +75,23 @@

    Value

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/links.md b/docs/reference/links.md new file mode 100644 index 00000000..7284c8b5 --- /dev/null +++ b/docs/reference/links.md @@ -0,0 +1,38 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser + +Return a list of websites that were used as references for Drugs/ +Carriers/ Enzymes/ Targets/ Transporters + +## Usage + +``` r +drugs_links() + +carriers_links() + +enzymes_links() + +targets_links() + +transporters_links() +``` + +## Value + +a tibble with 4 variables: + +- ref-id: + + Name of the source website + +- title: + + Identifier for this drug in the given resource + +- url: + + The url of the website + +- *parent_id*: + + drug/ carrier/ target/ enzyme/ transporter id diff --git a/docs/reference/merge_drugbank_onsides.html b/docs/reference/merge_drugbank_onsides.html new file mode 100644 index 00000000..3e00d6b4 --- /dev/null +++ b/docs/reference/merge_drugbank_onsides.html @@ -0,0 +1,141 @@ + +Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides • dbparser + Skip to contents + + +
    +
    +
    +

    Merge DrugBank and OnSIDES Database Objects

    + Source: R/merge_helpers.R +
    merge_drugbank_onsides.Rd
    +
    + +
    +

    Creates an integrated dvobject object by linking DrugBank dvobject with +OnSIDES dvobject using RxNorm CUIs as the bridge.

    +
    + +
    +

    Usage

    + 
    merge_drugbank_onsides(db_object, onsides_db)
    +
    + +
    +

    Arguments

    + + +
    db_object
    +

    A dvobject from `parseDrugBank()` OR an existing merged +dvobject (containing `$drugbank`).

    + + +
    onsides_db
    +

    A dvobject produced by `dbparser::parseOnSIDES()`.

    + +
    +
    +

    Value

    +

    A new dvobject containing the integrated data.

    +
    +
    +

    Details

    +

    This function performs the following key steps: +1. Creates a mapping table between DrugBank IDs and RxNorm CUIs from the DrugBank object. +2. Enriches the relevant OnSIDES tables (`vocab_rxnorm_ingredient` and optionally + `high_confidence`) by adding a `drugbank_id` column. +3. Assembles a new list object containing all original tables plus the enriched ones + and the ID mapping table itself.

    +

    The resulting object allows for powerful queries that span both mechanistic data from +DrugBank and clinical side-effect data from OnSIDES. +Supports piping and chaining with other merge functions.

    +
    +
    +

    See also

    +

    Other mergers: +merge_drugbank_twosides()

    +
    + +
    +

    Examples

    + 
    if (FALSE) { # \dontrun{
+# First, parse the individual databases
+drugbank <- parseDrugBank("path/to/drugbank.xml")
+onsides <- parseOnSIDES("path/to/onsides_csvs/")
+
+# Now, merge them into a single, powerful object
+merged_db <- merge_drugbank_onsides(drugbank, onsides)
+
+# --- Example Analysis: Find the protein targets of all drugs known to ---
+# --- cause the side effect "Hepatitis" with high confidence.        ---
+
+# 1. Find the MedDRA ID for "Hepatitis"
+hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>%
+  filter(meddra_name == "Hepatitis") %>%
+  pull(meddra_id)
+
+# 2. Find all drug ingredients linked to this effect in the high_confidence table
+drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>%
+  filter(effect_meddra_id == hepatitis_id) %>%
+  pull(drugbank_id) %>%
+  na.omit() %>%
+  unique()
+
+# 3. Look up the targets for these DrugBank IDs
+targets_of_interest <- merged_db$targets %>%
+  filter(parent_key %in% drug_ids_causing_hepatitis) %>%
+  select(drug_id = parent_key, target_name = name, gene_name)
+
+head(targets_of_interest)
+} # }
+
    +
    +
    + + +
    + + + + + + + diff --git a/docs/reference/merge_drugbank_onsides.md b/docs/reference/merge_drugbank_onsides.md new file mode 100644 index 00000000..cde6876f --- /dev/null +++ b/docs/reference/merge_drugbank_onsides.md @@ -0,0 +1,78 @@ +# Merge DrugBank and OnSIDES Database Objects + +Creates an integrated dvobject object by linking DrugBank dvobject with +OnSIDES dvobject using RxNorm CUIs as the bridge. + +## Usage + +``` r +merge_drugbank_onsides(db_object, onsides_db) +``` + +## Arguments + +- db_object: + + A dvobject from \`parseDrugBank()\` OR an existing merged dvobject + (containing \`\$drugbank\`). + +- onsides_db: + + A dvobject produced by \`dbparser::parseOnSIDES()\`. + +## Value + +A new dvobject containing the integrated data. + +## Details + +This function performs the following key steps: 1. Creates a mapping +table between DrugBank IDs and RxNorm CUIs from the DrugBank object. 2. +Enriches the relevant OnSIDES tables (\`vocab_rxnorm_ingredient\` and +optionally \`high_confidence\`) by adding a \`drugbank_id\` column. 3. +Assembles a new list object containing all original tables plus the +enriched ones and the ID mapping table itself. + +The resulting object allows for powerful queries that span both +mechanistic data from DrugBank and clinical side-effect data from +OnSIDES. Supports piping and chaining with other merge functions. + +## See also + +Other mergers: +[`merge_drugbank_twosides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.md) + +## Examples + +``` r +if (FALSE) { # \dontrun{ +# First, parse the individual databases +drugbank <- parseDrugBank("path/to/drugbank.xml") +onsides <- parseOnSIDES("path/to/onsides_csvs/") + +# Now, merge them into a single, powerful object +merged_db <- merge_drugbank_onsides(drugbank, onsides) + +# --- Example Analysis: Find the protein targets of all drugs known to --- +# --- cause the side effect "Hepatitis" with high confidence. --- + +# 1. Find the MedDRA ID for "Hepatitis" +hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% + filter(meddra_name == "Hepatitis") %>% + pull(meddra_id) + +# 2. Find all drug ingredients linked to this effect in the high_confidence table +drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% + filter(effect_meddra_id == hepatitis_id) %>% + pull(drugbank_id) %>% + na.omit() %>% + unique() + +# 3. Look up the targets for these DrugBank IDs +targets_of_interest <- merged_db$targets %>% + filter(parent_key %in% drug_ids_causing_hepatitis) %>% + select(drug_id = parent_key, target_name = name, gene_name) + +head(targets_of_interest) +} # } +``` diff --git a/docs/reference/merge_drugbank_twosides.html b/docs/reference/merge_drugbank_twosides.html new file mode 100644 index 00000000..33ace729 --- /dev/null +++ b/docs/reference/merge_drugbank_twosides.html @@ -0,0 +1,97 @@ + +Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides • dbparser + Skip to contents + + +
    +
    +
    +

    Merge a DrugBank dvobject with a TWOSIDES dvobject

    + Source: R/merge_helpers.R +
    merge_drugbank_twosides.Rd
    +
    + +
    +

    Integrates drug-drug interaction data from TWOSIDES with the rich mechanistic +information from DrugBank. This function is chainable and can accept a raw +DrugBank object or an already-merged dvobject.

    +
    + +
    +

    Usage

    + 
    merge_drugbank_twosides(db_object, twosides_db)
    +
    + +
    +

    Arguments

    + + +
    db_object
    +

    A dvobject from `parseDrugBank()` or an existing merged dvobject.

    + + +
    twosides_db
    +

    A dvobject from `parseTWOSIDES()`.

    + +
    +
    +

    Value

    +

    A new, nested dvobject with the TWOSIDES data added.

    +
    +
    +

    See also

    +

    Other mergers: +merge_drugbank_onsides()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/merge_drugbank_twosides.md b/docs/reference/merge_drugbank_twosides.md new file mode 100644 index 00000000..dc428969 --- /dev/null +++ b/docs/reference/merge_drugbank_twosides.md @@ -0,0 +1,30 @@ +# Merge a DrugBank dvobject with a TWOSIDES dvobject + +Integrates drug-drug interaction data from TWOSIDES with the rich +mechanistic information from DrugBank. This function is chainable and +can accept a raw DrugBank object or an already-merged dvobject. + +## Usage + +``` r +merge_drugbank_twosides(db_object, twosides_db) +``` + +## Arguments + +- db_object: + + A dvobject from \`parseDrugBank()\` or an existing merged dvobject. + +- twosides_db: + + A dvobject from \`parseTWOSIDES()\`. + +## Value + +A new, nested dvobject with the TWOSIDES data added. + +## See also + +Other mergers: +[`merge_drugbank_onsides()`](https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.md) diff --git a/docs/reference/parseDrugBank.html b/docs/reference/parseDrugBank.html index 0d247fc4..aa292bdf 100644 --- a/docs/reference/parseDrugBank.html +++ b/docs/reference/parseDrugBank.html @@ -1,71 +1,55 @@ -parseDrugBank — parseDrugBank • dbparserparseDrugBank — parseDrugBank • dbparser - - -
    -
    -
    -
    -

    parseDrugBank

    - Source: R/drugbank_parser.R - + +
    +
    +
    +
    +

    parseDrugBank

    + Source: R/drugbank_parser.R +
    parseDrugBank.Rd
    -
    +

    parses given DrugBank XML database into a dvobject. dvobject is a list of data.frames in which each data.frame represents a part of parsed data (i.e drugs, prices, carriers, ...)

    -
    +
    +

    Usage

    parseDrugBank(
   db_path,
   drug_options = NULL,
@@ -76,75 +60,73 @@ 
    parseDrugBank
    
 )
    -
    -

    Arguments

    -
    db_path
    +
    +

    Arguments

    + + +
    db_path

    string, full path for the DrugBank xml or zip file.

    -
    drug_options
    +
    drug_options

    character vector, list of sub drug related nodes names options to parse (default = NULL). Check drug_node_options() for all available options. If its value is `NULL` ONLY `drug_general_information` will be placed in the returned dvobject.

    -
    parse_salts
    +
    parse_salts

    boolean, parse salts info (default = FALSE)

    -
    parse_products
    +
    parse_products

    boolean, parse products info (default = FALSE)

    -
    references_options
    +
    references_options

    character vector, list of sub references related nodes names options to parse (default = NULL). Check references_node_options() for all available options.

    -
    cett_options
    +
    cett_options

    character vector, list of sub cett related nodes names options to parse (default = NULL). Check cett_nodes_options() for all available options.

    -
    -

    Value

    - - -

    dvobject

    +
    +

    Value

    +

    dvobject

    - - -
    +
    -
    + - - diff --git a/docs/reference/parseDrugBank.md b/docs/reference/parseDrugBank.md new file mode 100644 index 00000000..36c6f46c --- /dev/null +++ b/docs/reference/parseDrugBank.md @@ -0,0 +1,67 @@ +# parseDrugBank + +parses given DrugBank XML database into a dvobject. dvobject is a list +of data.frames in which each data.frame represents a part of parsed data +(i.e drugs, prices, carriers, ...) + +## Usage + +``` r +parseDrugBank( + db_path, + drug_options = NULL, + parse_salts = FALSE, + parse_products = FALSE, + references_options = NULL, + cett_options = NULL +) +``` + +## Arguments + +- db_path: + + **string**, full path for the **DrugBank** xml or zip file. + +- drug_options: + + **character vector**, list of sub drug related nodes names options to + parse (default = NULL). Check + [`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md) + for all available options. If its value is \`NULL\` ONLY + \`drug_general_information\` will be placed in the returned dvobject. + +- parse_salts: + + **boolean**, parse salts info (default = FALSE) + +- parse_products: + + **boolean**, parse products info (default = FALSE) + +- references_options: + + **character vector**, list of sub references related nodes names + options to parse (default = NULL). Check + [`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) + for all available options. + +- cett_options: + + **character vector**, list of sub cett related nodes names options to + parse (default = NULL). Check + [`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md) + for all available options. + +## Value + +dvobject + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/parseOnSIDES.html b/docs/reference/parseOnSIDES.html new file mode 100644 index 00000000..2d70f9cd --- /dev/null +++ b/docs/reference/parseOnSIDES.html @@ -0,0 +1,118 @@ + +Parse the OnSIDES Core Relational Database — parseOnSIDES • dbparser + Skip to contents + + +
    +
    +
    +

    Parse the OnSIDES Core Relational Database

    + Source: R/onsides_parser.R +
    parseOnSIDES.Rd
    +
    + +
    +

    Parses the core relational tables from the OnSIDES database.

    +
    + +
    +

    Usage

    + 
    parseOnSIDES(
+  dataDir,
+  include_high_confidence = TRUE,
+  db_version = NULL,
+  db_exported_date = NULL
+)
    +
    + +
    +

    Arguments

    + + +
    dataDir
    +

    A string specifying the path to the directory containing the +OnSIDES CSV files.

    + + +
    include_high_confidence
    +

    Logical. If TRUE (the default), the function +will also parse the `high_confidence.csv` file, which is a pre-aggregated +summary of ingredient-to-effect relationships. If the file is not found, +a warning is issued.

    + + +
    db_version
    +

    used onside version (default = NULL)

    + + +
    db_exported_date
    +

    used onside release date (default = NULL)

    + +
    +
    +

    Value

    +

    dvobject

    +
    +
    +

    See also

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseTWOSIDES(), +references_node_options()

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseTWOSIDES(), +references_node_options()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/parseOnSIDES.md b/docs/reference/parseOnSIDES.md new file mode 100644 index 00000000..12ac9954 --- /dev/null +++ b/docs/reference/parseOnSIDES.md @@ -0,0 +1,56 @@ +# Parse the OnSIDES Core Relational Database + +Parses the core relational tables from the OnSIDES database. + +## Usage + +``` r +parseOnSIDES( + dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL +) +``` + +## Arguments + +- dataDir: + + A string specifying the path to the directory containing the OnSIDES + CSV files. + +- include_high_confidence: + + Logical. If TRUE (the default), the function will also parse the + \`high_confidence.csv\` file, which is a pre-aggregated summary of + ingredient-to-effect relationships. If the file is not found, a + warning is issued. + +- db_version: + + used onside version (default = NULL) + +- db_exported_date: + + used onside release date (default = NULL) + +## Value + +dvobject + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/parseTWOSIDES.html b/docs/reference/parseTWOSIDES.html new file mode 100644 index 00000000..c0a1993e --- /dev/null +++ b/docs/reference/parseTWOSIDES.html @@ -0,0 +1,149 @@ + +Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES • dbparser + Skip to contents + + +
    +
    +
    +

    Parse the TWOSIDES Drug-Drug Interaction Database

    + Source: R/nsides_parsers.R +
    parseTWOSIDES.Rd
    +
    + +
    +

    Reads the TWOSIDES data file, which contains adverse event data for pairs of +drugs taken concurrently (N=2 interactions).

    +
    + +
    +

    Usage

    + 
    parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL)
    +
    + +
    +

    Arguments

    + + +
    twosides_file_path
    +

    Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz').

    + + +
    db_version
    +

    used twoside version (default = NULL)

    + + +
    db_exported_date
    +

    used twoside release date (default = NULL)

    + +
    +
    +

    Value

    +

    A dvobject of class `TWOSIDESDB` containing the `drug_drug_interactions` + data frame and associated metadata.

    +
    +
    +

    Details

    +

    TWOSIDES is a database of drug-drug interaction safety signals +mined from the FDA's Adverse Event Reporting System using the same +approach as is used to generate OffSIDES.

    +

    Database fields as follow:

    drug_1_rxnorn_id
    +

    RxNORM identifier for drug 1

    + +
    drug_1_concept_name
    +

    RxNORM name string for drug 1

    + +
    drug_2_rxnorm_id
    +

    RxNORM identifier for drug 2

    + +
    drug_2_concept_name
    +

    RxNORM name string for drug 3

    + +
    condition_meddra_id
    +

    MedDRA identifier for the side effect

    + +
    condition_concpet_name
    +

    MedDRA name string for the side effect

    + +
    A
    +

    The number of reports for the pair of drugs that report the side effect

    + +
    B
    +

    The number of reports for the pair of drugs that do not report the side effect

    + +
    C
    +

    The number of reports for other PSM matched drugs (including perhaps the single versions of drug 1 or drug 2) that report the side effect

    + +
    D
    +

    The number of reports for other PSM matched drugs and other side effects

    + +
    PRR
    +

    Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D))

    + +
    PRR_error
    +

    Error estimate of the PRR

    + +
    mean_reporting_frequency
    +

    Proportion of reports for the drug that report the side effect, A/(A+B)

    + + +
    +
    +

    See also

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseOnSIDES(), +references_node_options()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/parseTWOSIDES.md b/docs/reference/parseTWOSIDES.md new file mode 100644 index 00000000..87f87ab2 --- /dev/null +++ b/docs/reference/parseTWOSIDES.md @@ -0,0 +1,106 @@ +# Parse the TWOSIDES Drug-Drug Interaction Database + +Reads the +[TWOSIDES](https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz) +data file, which contains adverse event data for pairs of drugs taken +concurrently (N=2 interactions). + +## Usage + +``` r +parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL) +``` + +## Arguments + +- twosides_file_path: + + Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). + +- db_version: + + used twoside version (default = NULL) + +- db_exported_date: + + used twoside release date (default = NULL) + +## Value + +A dvobject of class \`TWOSIDESDB\` containing the +\`drug_drug_interactions\` data frame and associated metadata. + +## Details + +[TWOSIDES](https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz) +is a database of drug-drug interaction safety signals mined from the +FDA's Adverse Event Reporting System using the same approach as is used +to generate OffSIDES. + +Database fields as follow: + +- drug_1_rxnorn_id: + + RxNORM identifier for drug 1 + +- drug_1_concept_name: + + RxNORM name string for drug 1 + +- drug_2_rxnorm_id: + + RxNORM identifier for drug 2 + +- drug_2_concept_name: + + RxNORM name string for drug 3 + +- condition_meddra_id: + + MedDRA identifier for the side effect + +- condition_concpet_name: + + MedDRA name string for the side effect + +- A: + + The number of reports for the pair of drugs that report the side + effect + +- B: + + The number of reports for the pair of drugs that do not report the + side effect + +- C: + + The number of reports for other PSM matched drugs (including perhaps + the single versions of drug 1 or drug 2) that report the side effect + +- D: + + The number of reports for other PSM matched drugs and other side + effects + +- PRR: + + Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D)) + +- PRR_error: + + Error estimate of the PRR + +- mean_reporting_frequency: + + Proportion of reports for the drug that report the side effect, + A/(A+B) + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`references_node_options()`](https://docs.ropensci.org/dbparser/reference/references_node_options.md) diff --git a/docs/reference/parse_cett_node.html b/docs/reference/parse_cett_node.html index fd7e992c..4e1dc758 100644 --- a/docs/reference/parse_cett_node.html +++ b/docs/reference/parse_cett_node.html @@ -1,100 +1,77 @@ -Run all CETT related parsers — parse_cett_node • dbparser - - -
    -
    -
    -
    -

    Run all CETT related parsers

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    Run all CETT related parsers

    + Source: R/drugbank_parser.R +
    parse_cett_node.Rd
    -
    +

    Run all parsers that retrieve carriers, enzymes, targets and transporters related information

    -
    +
    +

    Usage

    parse_cett_node(cett_options)
    -
    -

    Value

    - - -

    a list of all drugs parsed tibbles

    +
    +

    Value

    +

    a list of all drugs parsed tibbles

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/parse_cett_node.md b/docs/reference/parse_cett_node.md new file mode 100644 index 00000000..e18acb8a --- /dev/null +++ b/docs/reference/parse_cett_node.md @@ -0,0 +1,14 @@ +# Run all CETT related parsers + +Run all parsers that retrieve carriers, enzymes, targets and +transporters related information + +## Usage + +``` r +parse_cett_node(cett_options) +``` + +## Value + +a list of all drugs parsed tibbles diff --git a/docs/reference/parse_drug_nodes.html b/docs/reference/parse_drug_nodes.html index 1a7b0251..738107f8 100644 --- a/docs/reference/parse_drug_nodes.html +++ b/docs/reference/parse_drug_nodes.html @@ -1,104 +1,82 @@ -Run all drug related parsers — parse_drug_nodes • dbparser - - -
    -
    -
    -
    -

    Run all drug related parsers

    - Source: R/drugbank_parser.R - + +
    +
    +
    +
    +

    Run all drug related parsers

    + Source: R/drugbank_parser.R +
    parse_drug_nodes.Rd
    -
    +

    Run all parsers that retrieve drugs related information

    -
    +
    +

    Usage

    parse_drug_nodes(drug_options)
    -
    -

    Arguments

    -
    drug_options
    +
    +

    Arguments

    + + +
    drug_options

    - list of options to parse

    -
    -

    Value

    - - -

    a list of all drugs parsed tibbles

    +
    +

    Value

    +

    a list of all drugs parsed tibbles

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/parse_drug_nodes.md b/docs/reference/parse_drug_nodes.md new file mode 100644 index 00000000..0e8a5cc7 --- /dev/null +++ b/docs/reference/parse_drug_nodes.md @@ -0,0 +1,19 @@ +# Run all drug related parsers + +Run all parsers that retrieve drugs related information + +## Usage + +``` r +parse_drug_nodes(drug_options) +``` + +## Arguments + +- drug_options: + + \- list of options to parse + +## Value + +a list of all drugs parsed tibbles diff --git a/docs/reference/parse_references_node.html b/docs/reference/parse_references_node.html index 0c29c728..00a23351 100644 --- a/docs/reference/parse_references_node.html +++ b/docs/reference/parse_references_node.html @@ -1,99 +1,75 @@ -Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node • dbparser - - -
    -
    -
    -
    -

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser

    + Source: R/drugbank_parser.R +
    parse_references_node.Rd
    -
    +

    Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser

    -
    +
    +

    Usage

    parse_references_node(references_options)
    -
    -

    Value

    - - -

    a list of all references for drugs, carriers, enzymes, targets or +

    +

    Value

    +

    a list of all references for drugs, carriers, enzymes, targets or transporters

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/parse_references_node.md b/docs/reference/parse_references_node.md new file mode 100644 index 00000000..64aa2ec5 --- /dev/null +++ b/docs/reference/parse_references_node.md @@ -0,0 +1,15 @@ +# Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser + +Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element +parser + +## Usage + +``` r +parse_references_node(references_options) +``` + +## Value + +a list of all references for drugs, carriers, enzymes, targets or +transporters diff --git a/docs/reference/read_drugbank_xml_db.html b/docs/reference/read_drugbank_xml_db.html index 77d09009..be36ac54 100644 --- a/docs/reference/read_drugbank_xml_db.html +++ b/docs/reference/read_drugbank_xml_db.html @@ -1,114 +1,93 @@ -Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db • dbparser - - -
    -
    -
    -
    -

    Reads DrugBank xml database and load it into memory.

    - Source: R/drug_common_utilities.R - + +
    +
    +
    +
    +

    Reads DrugBank xml database and load it into memory.

    + Source: R/drug_common_utilities.R +
    read_drugbank_xml_db.Rd
    -
    +

    read_drugbank_xml_db loads DrugBank xml database full tree into memory.

    -
    +
    +

    Usage

    read_drugbank_xml_db(db_path)
    -
    -

    Arguments

    -
    db_path
    +
    +

    Arguments

    + + +
    db_path

    string, full path for the DrugBank xml or zip file.

    -
    -

    Value

    - - -

    loaded DB or NULL

    +
    +

    Value

    +

    loaded DB or NULL

    -
    -

    Details

    +
    +

    Details

    This functions reads DrugBank xml database and load it into memory for later processing. Hence; this method must be called before any other function in the package and it needs to be called one time only.

    It takes one single mandatory argument which is the location of DrugBank db.

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/read_drugbank_xml_db.md b/docs/reference/read_drugbank_xml_db.md new file mode 100644 index 00000000..51cc467f --- /dev/null +++ b/docs/reference/read_drugbank_xml_db.md @@ -0,0 +1,29 @@ +# Reads **DrugBank** xml database and load it into memory. + +`read_drugbank_xml_db` loads **DrugBank** xml database full tree into +memory. + +## Usage + +``` r +read_drugbank_xml_db(db_path) +``` + +## Arguments + +- db_path: + + **string**, full path for the **DrugBank** xml or zip file. + +## Value + +loaded DB or NULL + +## Details + +This functions reads **DrugBank** xml database and load it into memory +for later processing. Hence; this method **must** be called before any +other function in the package and it needs to be called one time only. + +It takes one single mandatory argument which is the location of DrugBank +db. diff --git a/docs/reference/references_node_options.html b/docs/reference/references_node_options.html index be939ed8..93e54ee7 100644 --- a/docs/reference/references_node_options.html +++ b/docs/reference/references_node_options.html @@ -1,105 +1,83 @@ -returns references node valid options. — references_node_options • dbparser - - -
    -
    -
    -
    -

    returns references node valid options.

    - Source: R/drugbank_parser.R - + + + +
    +
    +
    +
    +

    returns references node valid options.

    + Source: R/drugbank_parser.R +
    references_node_options.Rd
    -
    +

    returns references node valid options.

    -
    +
    +

    Usage

    references_node_options()
    -
    -

    Value

    - - -

    list of references valid options

    +
    +

    Value

    +

    list of references valid options

    -
    -

    See also

    -

    Other parsers: -cett_nodes_options(), -drug_node_options(), -parseDrugBank()

    +
    +

    See also

    +

    Other parsers: +cett_nodes_options(), +drug_node_options(), +parseDrugBank(), +parseOnSIDES(), +parseTWOSIDES()

    -
    - -
    +
    -
    + - - diff --git a/docs/reference/references_node_options.md b/docs/reference/references_node_options.md new file mode 100644 index 00000000..97f0908f --- /dev/null +++ b/docs/reference/references_node_options.md @@ -0,0 +1,22 @@ +# returns references node valid options. + +returns references node valid options. + +## Usage + +``` r +references_node_options() +``` + +## Value + +list of references valid options + +## See also + +Other parsers: +[`cett_nodes_options()`](https://docs.ropensci.org/dbparser/reference/cett_nodes_options.md), +[`drug_node_options()`](https://docs.ropensci.org/dbparser/reference/drug_node_options.md), +[`parseDrugBank()`](https://docs.ropensci.org/dbparser/reference/parseDrugBank.md), +[`parseOnSIDES()`](https://docs.ropensci.org/dbparser/reference/parseOnSIDES.md), +[`parseTWOSIDES()`](https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.md) diff --git a/docs/reference/show_dvobject_metadata.html b/docs/reference/show_dvobject_metadata.html index 0a0b9a53..188892de 100644 --- a/docs/reference/show_dvobject_metadata.html +++ b/docs/reference/show_dvobject_metadata.html @@ -1,109 +1,106 @@ -init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes — show_dvobject_metadata • dbparser - - -
    -
    -
    -
    -

    init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes

    - Source: R/dvobject_metadata.R - + + + + + + +
    +
    +
    +
    +

    Display dvobject Metadata

    + Source: R/dvobject_metadata.R +
    show_dvobject_metadata.Rd
    -
    -

    init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes

    +
    +

    Displays information about passed dbobject object including basic info, +database metadata, and all data.frames contained within nested lists.

    -
    - 
    show_dvobject_metadata(dvobject)
    +
    +

    Usage

    + 
    show_dvobject_metadata(obj, return_df = FALSE)
    -
    -

    Arguments

    -
    dvobject
    -

    - dvobject list to show related metadata

    +
    +

    Arguments

    + + +
    obj
    +

    A dvobject

    -
    -
    -

    Value

    - -

    data.frame

    +
    return_df
    +

    Logical. If TRUE, returns metadata data.frame without printing. +Default is FALSE.

    + +
    +
    +

    Value

    +

    Invisibly returns a data.frame containing dvobject metadata

    +
    +
    +

    See also

    +

    Other utility: +add_database_info(), +subset_drugbank_dvobject(), +subset_onsides_dvobject()

    -
    - -
    +
    +

    Examples

    + 
    if (FALSE) { # \dontrun{
+display_merged_db_attrs(drugbank)
+metadata <- display_merged_db_attrs(drugbank, return_df = TRUE)
+} # }
+
+
    +
    +
    -
    + - - diff --git a/docs/reference/show_dvobject_metadata.md b/docs/reference/show_dvobject_metadata.md new file mode 100644 index 00000000..58081be3 --- /dev/null +++ b/docs/reference/show_dvobject_metadata.md @@ -0,0 +1,41 @@ +# Display dvobject Metadata + +Displays information about passed dbobject object including basic info, +database metadata, and all data.frames contained within nested lists. + +## Usage + +``` r +show_dvobject_metadata(obj, return_df = FALSE) +``` + +## Arguments + +- obj: + + A dvobject + +- return_df: + + Logical. If TRUE, returns metadata data.frame without printing. + Default is FALSE. + +## Value + +Invisibly returns a data.frame containing dvobject metadata + +## See also + +Other utility: +[`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md), +[`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md), +[`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) + +## Examples + +``` r +if (FALSE) { # \dontrun{ +display_merged_db_attrs(drugbank) +metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) +} # } +``` diff --git a/docs/reference/subset_drugbank_dvobject.html b/docs/reference/subset_drugbank_dvobject.html new file mode 100644 index 00000000..c862a4d6 --- /dev/null +++ b/docs/reference/subset_drugbank_dvobject.html @@ -0,0 +1,109 @@ + +Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject • dbparser + Skip to contents + + +
    +
    +
    +

    Subset a DrugBank dvobject by a vector of DrugBank IDs

    + Source: R/utils.R +
    subset_drugbank_dvobject.Rd
    +
    + +
    +

    Subset a DrugBank dvobject by a vector of DrugBank IDs

    +
    + +
    +

    Usage

    + 
    subset_drugbank_dvobject(dvobject, drug_ids)
    +
    + +
    +

    Arguments

    + + +
    dvobject
    +

    The dvobject from `parseDrugBank()`.

    + + +
    drug_ids
    +

    A character vector of `drugbank_id` values to keep.

    + +
    +
    +

    Value

    +

    A new, smaller dvobject with the same structure and attributes.

    +
    +
    +

    Details

    +

    Intelligently filters a DrugBank dvobject to retain only the data associated +with a specified list of drugbank_ids. It correctly handles the deep, +multi-level nested structure of the entire object, including the complex +relationships within the `cett` list.

    +
    +
    +

    See also

    +

    Other utility: +add_database_info(), +show_dvobject_metadata(), +subset_onsides_dvobject()

    +
    + +
    +

    Examples

    + 
    if (FALSE) { # \dontrun{
+library(dbparser)
+one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank,
+                                     drug_ids = "DB00001")
+} # }
+
    +
    +
    + + +
    + + + + + + + diff --git a/docs/reference/subset_drugbank_dvobject.md b/docs/reference/subset_drugbank_dvobject.md new file mode 100644 index 00000000..7e6b2406 --- /dev/null +++ b/docs/reference/subset_drugbank_dvobject.md @@ -0,0 +1,47 @@ +# Subset a DrugBank dvobject by a vector of DrugBank IDs + +Subset a DrugBank dvobject by a vector of DrugBank IDs + +## Usage + +``` r +subset_drugbank_dvobject(dvobject, drug_ids) +``` + +## Arguments + +- dvobject: + + The dvobject from \`parseDrugBank()\`. + +- drug_ids: + + A character vector of \`drugbank_id\` values to keep. + +## Value + +A new, smaller dvobject with the same structure and attributes. + +## Details + +Intelligently filters a DrugBank dvobject to retain only the data +associated with a specified list of drugbank_ids. It correctly handles +the deep, multi-level nested structure of the entire object, including +the complex relationships within the \`cett\` list. + +## See also + +Other utility: +[`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md), +[`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md), +[`subset_onsides_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.md) + +## Examples + +``` r +if (FALSE) { # \dontrun{ +library(dbparser) +one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, + drug_ids = "DB00001") +} # } +``` diff --git a/docs/reference/subset_onsides_dvobject.html b/docs/reference/subset_onsides_dvobject.html new file mode 100644 index 00000000..4bb8877d --- /dev/null +++ b/docs/reference/subset_onsides_dvobject.html @@ -0,0 +1,96 @@ + +Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject • dbparser + Skip to contents + + +
    +
    +
    +

    Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware)

    + Source: R/utils.R +
    subset_onsides_dvobject.Rd
    +
    + +
    +

    Intelligently filters an OnSIDES dvobject by cascading filters through the +relational tables, ensuring the final subset is self-consistent.

    +
    + +
    +

    Usage

    + 
    subset_onsides_dvobject(dvobject, ingredient_ids)
    +
    + +
    +

    Arguments

    + + +
    dvobject
    +

    A dvobject from `parseOnSIDES()`.

    + + +
    ingredient_ids
    +

    A character vector of RxNorm CUIs (ingredients) to keep.

    + +
    +
    +

    Value

    +

    A new, smaller dvobject with the same structure.

    +
    +
    +

    See also

    +

    Other utility: +add_database_info(), +show_dvobject_metadata(), +subset_drugbank_dvobject()

    +
    + +
    + + +
    + + + + + + + diff --git a/docs/reference/subset_onsides_dvobject.md b/docs/reference/subset_onsides_dvobject.md new file mode 100644 index 00000000..524fe7bc --- /dev/null +++ b/docs/reference/subset_onsides_dvobject.md @@ -0,0 +1,31 @@ +# Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) + +Intelligently filters an OnSIDES dvobject by cascading filters through +the relational tables, ensuring the final subset is self-consistent. + +## Usage + +``` r +subset_onsides_dvobject(dvobject, ingredient_ids) +``` + +## Arguments + +- dvobject: + + A dvobject from \`parseOnSIDES()\`. + +- ingredient_ids: + + A character vector of RxNorm CUIs (ingredients) to keep. + +## Value + +A new, smaller dvobject with the same structure. + +## See also + +Other utility: +[`add_database_info()`](https://docs.ropensci.org/dbparser/reference/add_database_info.md), +[`show_dvobject_metadata()`](https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.md), +[`subset_drugbank_dvobject()`](https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.md) diff --git a/docs/reference/targets.html b/docs/reference/targets.html index cdfb3334..c4ba25d7 100644 --- a/docs/reference/targets.html +++ b/docs/reference/targets.html @@ -1,261 +1,8 @@ - - - + - - - - -Extracts the drug targ element and return data as tibble. — targets • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets returns tibble of drug targ elements.

    -
    - - 
    targets(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug target node attributes date frame

    -

    Details

    - -

    This functions extracts the target element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_articles(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets()
-
-# will throw an error, as database_connection is NULL
-targets(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets(save_table = TRUE, save_csv = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-#  location and return parsed tibble.
-# If the csv exist override it and return it.
-targets(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_actions.html b/docs/reference/targets_actions.html index 6fdd7561..49c4d12f 100644 --- a/docs/reference/targets_actions.html +++ b/docs/reference/targets_actions.html @@ -1,264 +1,8 @@ - - - + - - - - -Extracts the drug targ actions element and return data as tibble. — targets_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ actions element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_actions returns tibble of drug targ -actions elements.

    -
    - - 
    targets_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ actions node attributes date frame

    -

    Details

    - -

    This functions extracts the targ actions element of drug node in drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and - database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_articles(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_actions()
-
-# will throw an error, as database_connection is NULL
-targets_actions(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_actions(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_actions(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_actions(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_articles.html b/docs/reference/targets_articles.html index b2dba150..b95e027f 100644 --- a/docs/reference/targets_articles.html +++ b/docs/reference/targets_articles.html @@ -1,267 +1,8 @@ - - - + - - - - -Extracts the drug targ articles element and return data as tibble. — targets_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ articles element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_articles returns tibble of drug targ -articles elements.

    -
    - - 
    targets_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ articles node attributes date frame

    -

    Details

    - -

    This functions extracts the targ articles element of drug node in drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_articles()
-
-# will throw an error, as database_connection is NULL
-targets_articles(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_articles(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_articles(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_attachments.html b/docs/reference/targets_attachments.html new file mode 100644 index 00000000..2066a855 --- /dev/null +++ b/docs/reference/targets_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_links.html b/docs/reference/targets_links.html index c6cabd56..b768dff2 100644 --- a/docs/reference/targets_links.html +++ b/docs/reference/targets_links.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug targ links element and return data as tibble. — targets_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ links element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_links returns tibble of drug targ links - elements.

    -
    - - 
    targets_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ_links node attributes date frame

    -

    Details

    - -

    This functions extracts the targ links element of drug node in -DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_articles(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets_textbooks(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_links()
-
-# will throw an error, as database_connection is NULL
-targets_links(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_links(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_links(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in
-#  current location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_links(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/targets_polypep_ex_ident.html b/docs/reference/targets_polypep_ex_ident.html new file mode 100644 index 00000000..7fd02f47 --- /dev/null +++ b/docs/reference/targets_polypep_ex_ident.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides.html b/docs/reference/targets_polypeptides.html new file mode 100644 index 00000000..554cbd6b --- /dev/null +++ b/docs/reference/targets_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides_go.html b/docs/reference/targets_polypeptides_go.html new file mode 100644 index 00000000..bda310f8 --- /dev/null +++ b/docs/reference/targets_polypeptides_go.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides_pfams.html b/docs/reference/targets_polypeptides_pfams.html new file mode 100644 index 00000000..cac389d9 --- /dev/null +++ b/docs/reference/targets_polypeptides_pfams.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_polypeptides_syn.html b/docs/reference/targets_polypeptides_syn.html new file mode 100644 index 00000000..c0f768c9 --- /dev/null +++ b/docs/reference/targets_polypeptides_syn.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/targets_textbooks.html b/docs/reference/targets_textbooks.html index b13f3e0c..088dfbad 100644 --- a/docs/reference/targets_textbooks.html +++ b/docs/reference/targets_textbooks.html @@ -1,268 +1,8 @@ - - - + - - - - -Extracts the drug targ textbooks element and return data as tibble. — targets_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug targ textbooks element and return data as tibble.

    - Source: R/drug_targets_node_parser.R - -
    - -
    -

    targets_textbooks returns tibble of drug - targ textbooks elements.

    -
    - - 
    targets_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug targ textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the targ textbooks element of drug node in - drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other targets: -targets_actions(), -targets_articles(), -targets_links(), -targets_polypeptide_ext_ident(), -targets_polypeptide_go(), -targets_polypeptide_pfams(), -targets_polypeptide_syn(), -targets_polypeptide(), -targets()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-targets_textbooks()
-
-# will throw an error, as database_connection is NULL
-targets_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-targets_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_textbooks(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-targets_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-targets_textbooks(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters.html b/docs/reference/transporters.html index d3ee5976..c4ba25d7 100644 --- a/docs/reference/transporters.html +++ b/docs/reference/transporters.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug transporters element and return data as tibble. — transporters • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters returns tibble of drug transporters -elements.

    -
    - - 
    transporters(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters element of drug node in - DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters()
-
-# will throw an error, as database_connection is NULL
-transporters(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in
-# current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not
-# exist in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters(save_table = TRUE, save_csv = TRUE,
-database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters(save_csv = TRUE, csv_path = TRUE, override = TRUE)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_actions.html b/docs/reference/transporters_actions.html index fff9be35..49c4d12f 100644 --- a/docs/reference/transporters_actions.html +++ b/docs/reference/transporters_actions.html @@ -1,265 +1,8 @@ - - - + - - - - -Extracts the drug transporters actions element and return data as tibble. — transporters_actions • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters actions element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters actions returns tibble of drug - transporters -actions elements.

    -
    - - 
    transporters_actions(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in -the new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters actions node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters actions element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_articles(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_actions()
-
-# will throw an error, as database_connection is NULL
-transporters_actions(save_table = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_actions(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_actions(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_actions(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location
-#  and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_actions(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_articles.html b/docs/reference/transporters_articles.html index 4134e363..b95e027f 100644 --- a/docs/reference/transporters_articles.html +++ b/docs/reference/transporters_articles.html @@ -1,266 +1,8 @@ - - - + - - - - -Extracts the drug transporters articles element and return data as -tibble. — transporters_articles • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters articles element and return data as -tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters articles returns tibble of drug -transporters articles elements.

    -
    - - 
    transporters_articles(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters articles node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters articles element of drug node in - drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_articles()
-
-# will throw an error, as database_connection is NULL
-transporters_articles(save_table = TRUE)
-
-# save parsed tibble as csv if it does not exist in current location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_articles(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_articles(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_articles(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_articles(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_attachments.html b/docs/reference/transporters_attachments.html new file mode 100644 index 00000000..2066a855 --- /dev/null +++ b/docs/reference/transporters_attachments.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_links.html b/docs/reference/transporters_links.html index 63fe685e..b768dff2 100644 --- a/docs/reference/transporters_links.html +++ b/docs/reference/transporters_links.html @@ -1,267 +1,8 @@ - - - + - - - - -Extracts the drug transporters links element and return data as tibble. — transporters_links • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters links element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters_links returns tibble of drug -transporters_links elements.

    -
    - - 
    transporters_links(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters links node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters links element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_links()
-
-# will throw an error, as database_connection is NULL
-transporters_links(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_links(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_links(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_links(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_links(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_polypep_ex_ident.html b/docs/reference/transporters_polypep_ex_ident.html index b0a6bde6..7fd02f47 100644 --- a/docs/reference/transporters_polypep_ex_ident.html +++ b/docs/reference/transporters_polypep_ex_ident.html @@ -1,276 +1,8 @@ - - - + - - - - -Extracts the drug transporters polypeptides external identifiers - element and return data as tibble. — transporters_polypep_ex_ident • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters polypeptides external identifiers - element and return data as tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters_polypep_ex_ident -returns tibble of drug transporters polypeptides external identifiers -elements.

    -
    - - 
    transporters_polypep_ex_ident(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters polypeptides external identifiers - node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters polypeptides external - identifiers element of drug node in DrugBank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_links(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters_textbooks(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_polypep_ex_ident()
-
-# will throw an error, as database_connection is NULL
-transporters_polypep_ex_ident(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_polypep_ex_ident(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_polypep_ex_ident(
-  save_table = TRUE, save_csv = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in given location
-# and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_polypep_ex_ident(
-  save_csv = TRUE, csv_path = TRUE
-)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_polypep_ex_ident(
-  save_csv = TRUE, csv_path = TRUE, override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/reference/transporters_polypeptides.html b/docs/reference/transporters_polypeptides.html new file mode 100644 index 00000000..554cbd6b --- /dev/null +++ b/docs/reference/transporters_polypeptides.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_polypeptides_go.html b/docs/reference/transporters_polypeptides_go.html new file mode 100644 index 00000000..bda310f8 --- /dev/null +++ b/docs/reference/transporters_polypeptides_go.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_polypeptides_pfams.html b/docs/reference/transporters_polypeptides_pfams.html new file mode 100644 index 00000000..cac389d9 --- /dev/null +++ b/docs/reference/transporters_polypeptides_pfams.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_polypeptides_syn.html b/docs/reference/transporters_polypeptides_syn.html new file mode 100644 index 00000000..c0f768c9 --- /dev/null +++ b/docs/reference/transporters_polypeptides_syn.html @@ -0,0 +1,8 @@ + + + + + + + + diff --git a/docs/reference/transporters_textbooks.html b/docs/reference/transporters_textbooks.html index 4cbb1983..088dfbad 100644 --- a/docs/reference/transporters_textbooks.html +++ b/docs/reference/transporters_textbooks.html @@ -1,272 +1,8 @@ - - - + - - - - -Extracts the drug transporters textbooks element and return data as - tibble. — transporters_textbooks • dbparser - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - -
    -
    - - - - -
    - -
    -
    -
    -

    Extracts the drug transporters textbooks element and return data as - tibble.

    - Source: R/drug_transporter_node_parser.R - -
    - -
    -

    transporters_textbooks returns tibble of drug -transporters - textbooks elements.

    -
    - - 
    transporters_textbooks(
-  save_table = FALSE,
-  save_csv = FALSE,
-  csv_path = ".",
-  override_csv = FALSE,
-  database_connection = NULL
-)
    - -

    Arguments

    - - - - - - - - - - - - - - - - - - - - - - -
    save_table

    boolean, save table in database if true.

    save_csv

    boolean, save csv version of parsed tibble if true

    csv_path

    location to save csv files into it, default is current -location, save_csv must be true

    override_csv

    override existing csv, if any, in case it is true in the -new parse operation

    database_connection

    DBI connection object that holds a connection to -user defined database. If save_table is enabled without providing -value for this function an error will be thrown.

    - -

    Value

    - -

    drug transporters textbooks node attributes date frame

    -

    Details

    - -

    This functions extracts the transporters textbooks element of drug node in -drugbank -xml database with the option to save it in a predefined database via -passed database connection. It takes two optional arguments to -save the returned tibble in the database save_table and -database_connection. -It must be called after read_drugbank_xml_db function like -any other parser function. -If read_drugbank_xml_db is called before for any reason, so -no need to call it again before calling this function.

    -

    See also

    - -

    Other transporters: -transporters_actions(), -transporters_articles(), -transporters_links(), -transporters_polypep_ex_ident(), -transporters_polypeptide_go(), -transporters_polypeptide_pfams(), -transporters_polypeptide_syn(), -transporters_polypeptide(), -transporters()

    - -

    Examples

    - 
    if (FALSE) {
-# return only the parsed tibble
-transporters_textbooks()
-
-# will throw an error, as database_connection is NULL
-transporters_textbooks(save_table = TRUE)
-
-# save in database in SQLite in memory database and return parsed tibble
-sqlite_con <- DBI::dbConnect(RSQLite::SQLite())
-transporters_textbooks(save_table = TRUE, database_connection = sqlite_con)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_textbooks(save_csv = TRUE)
-
-# save in database, save parsed tibble as csv if it does not exist
-# in current location and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_textbooks(save_table = TRUE, save_csv = TRUE)
-
-# save parsed tibble as csv if it does not exist in given location
-#  and return parsed tibble.
-# If the csv exist before read it and return its data.
-transporters_textbooks(save_csv = TRUE, csv_path = TRUE)
-
-# save parsed tibble as csv if it does not exist in current
-# location and return parsed tibble.
-# If the csv exist override it and return it.
-transporters_textbooks(
-  save_csv = TRUE, csv_path = TRUE,
-  override = TRUE
-)
-}
    -
    - -
    - - - -
    - - - - - - diff --git a/docs/search.json b/docs/search.json new file mode 100644 index 00000000..e4570c09 --- /dev/null +++ b/docs/search.json @@ -0,0 +1 @@ +[{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"DrugBank database global gold standard drug information, containing rich data chemical structures, pharmacology, molecular targets. However, raw data provided massive, complex XML file difficult use statistical analysis. dbparser solves problem. transforms complex XML Drugverse Object (dvobject)—structured collection R data frames ready analysis. tutorial, demonstrate : Parse database. Explore data structure. Visualize key insights using dplyr canvasXpress.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"the-parsing-workflow","dir":"Articles","previous_headings":"1. Loading Data","what":"The Parsing Workflow","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"real-world scenario, parse full XML database (downloaded DrugBank) using parseDrugBank().","code":"library(dbparser) # Parse the full XML file (this creates a dvobject) # drugbank_db <- parseDrugBank(\"drugbank_full_database.xml\")"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"loading-sample-data","dir":"Articles","previous_headings":"1. Loading Data","what":"Loading Sample Data","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"vignette, load curated sample datasets included package. represent specific tables found inside full dvobject.","code":"suppressPackageStartupMessages({ library(tidyr) library(dplyr) library(tibble) library(canvasXpress) library(dbparser) }) # Load sample tables representing parts of the parsed dvobject drugs <- readRDS(system.file(\"drugs.RDS\", package = \"dbparser\")) drug_groups <- readRDS(system.file(\"drug_groups.RDS\", package = \"dbparser\")) drug_targets_actions <- readRDS(system.file(\"targets_actions.RDS\", package = \"dbparser\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-the-drug-landscape","dir":"Articles","previous_headings":"","what":"2. Analysis: The Drug Landscape","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"universe approved drugs look like? Let’s analyze composition database drug type (Small Molecule vs. Biotech).","code":"# Prepare data: Count drugs by type type_stat <- drugs %>% group_by(type) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% column_to_rownames(\"type\") # Visualize canvasXpress( data = type_stat, graphType = \"Bar\", title = \"Composition of DrugBank: Drug Types\", showSampleNames = FALSE, legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-approval-status","dir":"Articles","previous_headings":"","what":"3. Analysis: Approval Status","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Drugs categorized groups “approved”, “investigational”, “experimental”. complexity (Biotech vs. Small Molecule) differ across groups?","code":"# Prepare data: Cross-tabulate Type vs Group group_stat <- drugs %>% full_join(drug_groups, by = \"drugbank_id\") %>% group_by(type, group) %>% summarise(count = n(), .groups = 'drop') %>% pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% column_to_rownames(\"type\") # Visualize with a Stacked Bar Chart canvasXpress( data = group_stat, graphType = \"Stacked\", graphOrientation = \"horizontal\", title = \"Drug Types by Approval Status\", xAxisTitle = \"Number of Drugs\", legendPosition = \"bottom\", xAxis2Show = FALSE )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"analysis-molecular-mechanisms","dir":"Articles","previous_headings":"","what":"4. Analysis: Molecular Mechanisms","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"One DrugBank’s valuable features detailed information drugs interact targets (Proteins, Enzymes, etc.). drugs mostly inhibitors, agonists, antagonists?","code":"# Prepare data: Top 10 most common Mechanisms of Action targetActionCounts <- drug_targets_actions %>% group_by(action) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% slice_head(n = 10) %>% column_to_rownames(\"action\") # Visualize canvasXpress( data = targetActionCounts, graphType = \"Bar\", graphOrientation = \"vertical\", colorBy = \"Count\", title = \"Top 10 Mechanisms of Action\", xAxisTitle = \"Number of Interactions\", showSampleNames = FALSE, legendPosition = \"none\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser.html","id":"next-steps-integrated-pharmacovigilance","dir":"Articles","previous_headings":"","what":"5. Next Steps: Integrated Pharmacovigilance","title":"Unlocking DrugBank: Parsing and Visualizing Mechanistic Data","text":"Now mastered mechanistic data DrugBank, can combine real-world data! dbparser now supports OnSIDES (Adverse Events) TWOSIDES (Drug-Drug Interactions). Check Integrated Pharmacovigilance Vignette learn merge databases perform polypharmacy risk analysis.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"the-hub-and-spoke-architecture","dir":"Articles","previous_headings":"","what":"The “Hub and Spoke” Architecture","title":"Introducing dbparser 2.2.0","text":"Version 2.2.0 moves beyond simple XML parsing. re-engineered package around “Hub Spoke” integration model: Hub: DrugBank serves anchor, providing stable molecular definitions. Spokes: OnSIDES TWOSIDES provide phenotypic clinical layers. introduced specific functions bridge worlds. new merge_drugbank_onsides() merge_drugbank_twosides() functions don’t just combine lists; perform intelligent “double joins” ID mapping (using RxNorm CUIs) ensure molecular data correctly linked clinical outcomes.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"pipeline-ready-pharmacovigilance","dir":"Articles","previous_headings":"","what":"Pipeline-Ready Pharmacovigilance","title":"Introducing dbparser 2.2.0","text":"One main design goals usability. new merge functions “chainable,” meaning integrate seamlessly tidyverse. can now build massive, multi-domain pharmacovigilance dataset three lines R code: result unified dvobject (DrugVerse Object) contains mechanistic data, label data, interaction data, enriched common identifiers.","code":"library(dbparser) library(dplyr) final_db <- parseDrugBank(\"data/drugbank.xml\") %>% merge_drugbank_onsides(parseOnSIDES(\"data/onsides/\")) %>% merge_drugbank_twosides(parseTWOSIDES(\"data/twosides.csv.gz\"))"},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"new-tools-for-reproducibility","dir":"Articles","previous_headings":"","what":"New Tools for Reproducibility","title":"Introducing dbparser 2.2.0","text":"support developers educators, also exposed internal subsetting engines (subset_drugbank_dvobject subset_onsides_dvobject). schema-aware functions allow slice massive databases consistent, shareable micro-datasets—perfect creating unit tests teaching materials.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"a-scientific-case-study","dir":"Articles","previous_headings":"","what":"A Scientific Case Study","title":"Introducing dbparser 2.2.0","text":"demonstrate power new workflow, included comprehensive new vignette: Integrated Pharmacovigilance tutorial, perform live analysis Leuprolide (hormone therapy) Calcitriol (Vitamin D). define individual side effect profiles using OnSIDES, use new TWOSIDES integration quantify specific risks—Anaemia—arise two drugs prescribed together.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/dbparser_2_2.html","id":"availability","dir":"Articles","previous_headings":"","what":"Availability","title":"Introducing dbparser 2.2.0","text":"dbparser 2.2.0 available now. can install GitHub get latest features immediately, case available CRAN yet. look forward seeing community builds new capabilities!","code":"devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"modern pharmacovigilance, analyzing drugs isolation often insufficient. Patients frequently take multiple medications, leading complex Drug-Drug Interactions (DDIs). dbparser package now provides unified framework analyze complete safety profile drug: Mechanism: Biological targets pathways DrugBank. Phenotype (Single Drug): Real-world adverse events OnSIDES. Polypharmacy (Combinations): Interaction risks TWOSIDES. vignette demonstrates complete workflow: loading three databases, merging single dvobject, performing scientific case study interaction Leuprolide Calcitriol.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"prerequisites","dir":"Articles","previous_headings":"","what":"Prerequisites","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"library(dbparser) library(dplyr) library(tidyr) library(canvasXpress) library(data.table)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"loading-and-inspecting-data","dir":"Articles","previous_headings":"","what":"1. Loading and Inspecting Data","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"use curated sample data files included dbparser package demonstrate workflow.","code":""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-drugbank-the-hub","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.1 Load DrugBank (The Hub)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"First, load mechanistic data.","code":"# Load sample DrugBank data included in the package drugbank_path <- system.file(\"two_drugs.RDS\", package = \"dbparser\") drugbank_db <- readRDS(drugbank_path) # Review the drugbank object structure show_dvobject_metadata(drugbank_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 55 3 1.5 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original DrugBank 5.1 2025-01-02 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugs$general_information 2 15 8 Kb #> drugs$drug_classification 2 9 3.8 Kb #> drugs$synonyms 15 4 3.6 Kb #> drugs$pharmacology 2 12 18.1 Kb #> drugs$international_brands 9 3 2.7 Kb #> drugs$mixtures 5 3 2 Kb #> drugs$packagers 35 3 6.2 Kb #> drugs$manufacturers 13 4 2.9 Kb #> drugs$prices 16 5 4.6 Kb #> drugs$categories 58 3 9.2 Kb #> drugs$dosages 189 4 17.4 Kb #> drugs$atc_codes 4 10 4.3 Kb #> drugs$patents 35 6 8.6 Kb #> drugs$drug_interactions 1645 4 514.7 Kb #> drugs$sequences 1 3 1.3 Kb #> drugs$calculated_properties 26 4 5.6 Kb #> drugs$experimental_properties 5 4 2.4 Kb #> drugs$external_identifiers 30 3 4.7 Kb #> drugs$pdb_entries 19 2 2.4 Kb #> drugs$affected_organisms 2 2 1.2 Kb #> drugs$groups 4 2 1.3 Kb #> drugs$external_links 5 3 2.1 Kb #> salts 2 8 2.8 Kb #> products 190 19 68.6 Kb #> references$drugs$articles 13 4 6.3 Kb #> references$drugs$links 11 4 6.1 Kb #> references$carriers$books 1 4 1.6 Kb #> references$carriers$articles 15 4 5.4 Kb #> references$enzymes$books 33 4 8.2 Kb #> references$enzymes$articles 1573 4 485.5 Kb #> references$enzymes$links 615 4 164.4 Kb #> references$enzymes$attachments 55 4 20 Kb #> references$targets$articles 101 4 27.4 Kb #> references$targets$links 14 4 7.1 Kb #> cett$carriers$general_information 1 6 1.9 Kb #> cett$carriers$actions 2 2 1.2 Kb #> cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> cett$carriers$polypeptides$synonyms 10 2 2 Kb #> cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> cett$carriers$polypeptides$go 2 3 1.5 Kb #> cett$enzymes$general_information 2 8 2.6 Kb #> cett$enzymes$actions 7 2 1.5 Kb #> cett$enzymes$polypeptides$general_information 2 20 14 Kb #> cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> cett$enzymes$polypeptides$go 21 3 3.6 Kb #> cett$targets$general_information 4 6 2.6 Kb #> cett$targets$actions 10 2 1.9 Kb #> cett$targets$polypeptides$general_information 4 20 14.2 Kb #> cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> cett$targets$polypeptides$pfams 5 3 2.1 Kb #> cett$targets$polypeptides$go 37 3 5.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-onsides-single-drug-labels","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.2 Load OnSIDES (Single-Drug Labels)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Next, load adverse event data extracted FDA labels.","code":"# Load sample OnSIDES data included in the package onsides_path <- system.file(\"onside.RDS\", package = \"dbparser\") onsides_db <- readRDS(onsides_path) # Review the onsides_db object structure show_dvobject_metadata(onsides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 8 0 2.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original OnSIDES 3.1.1 April 2025 #> #> === DATA.FRAMES === #> Path Rows Cols Size #> product_adverse_effect 52745 7 2.2 Mb #> high_confidence 2 2 1.4 Kb #> product_label 95 5 39.7 Kb #> product_to_rxnorm 160 2 5.5 Kb #> vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> vocab_meddra_adverse_effect 347 3 31.6 Kb #> vocab_rxnorm_ingredient 3 3 2.1 Kb #> vocab_rxnorm_product 17 3 4.9 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"load-twosides-drug-interactions","dir":"Articles","previous_headings":"1. Loading and Inspecting Data","what":"1.3 Load TWOSIDES (Drug Interactions)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, load dataset containing adverse events reported two drugs taken simultaneously.","code":"# Load sample TWOSIDES data included in the package twosides_path <- system.file(\"twoside_raw.zip\", package = \"dbparser\") if(file.exists(twosides_path)) { twosides_db <- parseTWOSIDES(twosides_path) } else { # Fallback for demonstration if file is not yet in the build # Mocking structure similar to actual TWOSIDES output twosides_db <- list(drug_drug_interactions = data.table( drug_1_rxnorm_id = \"42375\", drug_1_concept_name = \"Leuprolide\", drug_2_rxnorm_id = \"1894\", drug_2_concept_name = \"Calcitriol\", condition_meddra_id = \"10002034\", condition_concept_name = \"Anaemia\", PRR = \"13.33\", mean_reporting_frequency = \"0.12\" )) class(twosides_db) <- c(\"TWOSIDESDb\", \"dvobject\", \"list\") attr(twosides_db, \"original_db_info\") <- list(type=\"TWOSIDES\", version=\"2.0\") } # Review structure show_dvobject_metadata(twosides_db) #> === BASIC INFO === #> Class Total_DataFrames Top_Level_Lists Object_Size #> 1 dvobject 1 0 217.6 Kb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> Original TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"merging-the-databases-chaining","dir":"Articles","previous_headings":"","what":"2. Merging the Databases (Chaining)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"integrate databases chain. First, merge OnSIDES DrugBank, merge TWOSIDES result. creates single “Hub Spoke” object centered DrugBank.","code":"# Step 1: Merge DrugBank + OnSIDES db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) # Step 2: Merge Result + TWOSIDES # The function is chainable and automatically detects the existing data final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) # Review final object structure # Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' show_dvobject_metadata(final_db) #> === BASIC INFO === #> Class Total_DataFrames #> 1 DrugBankTWOSIDESDb, DrugBankOnSIDESDb, dvobject 68 #> Top_Level_Lists Object_Size #> 1 4 4.3 Mb #> #> === DATABASE METADATA === #> Database Type Version Export_Date #> First Database DrugBank 5.1 2025-01-02 #> Second Database TWOSIDESDB Unknown Unknown #> #> === DATA.FRAMES === #> Path Rows Cols Size #> drugbank$drugs$general_information 2 15 8 Kb #> drugbank$drugs$drug_classification 2 9 3.8 Kb #> drugbank$drugs$synonyms 15 4 3.6 Kb #> drugbank$drugs$pharmacology 2 12 18.1 Kb #> drugbank$drugs$international_brands 9 3 2.7 Kb #> drugbank$drugs$mixtures 5 3 2 Kb #> drugbank$drugs$packagers 35 3 6.2 Kb #> drugbank$drugs$manufacturers 13 4 2.9 Kb #> drugbank$drugs$prices 16 5 4.6 Kb #> drugbank$drugs$categories 58 3 9.2 Kb #> drugbank$drugs$dosages 189 4 17.4 Kb #> drugbank$drugs$atc_codes 4 10 4.3 Kb #> drugbank$drugs$patents 35 6 8.6 Kb #> drugbank$drugs$drug_interactions 1645 4 514.7 Kb #> drugbank$drugs$sequences 1 3 1.3 Kb #> drugbank$drugs$calculated_properties 26 4 5.6 Kb #> drugbank$drugs$experimental_properties 5 4 2.4 Kb #> drugbank$drugs$external_identifiers 30 3 4.7 Kb #> drugbank$drugs$pdb_entries 19 2 2.4 Kb #> drugbank$drugs$affected_organisms 2 2 1.2 Kb #> drugbank$drugs$groups 4 2 1.3 Kb #> drugbank$drugs$external_links 5 3 2.1 Kb #> drugbank$salts 2 8 2.8 Kb #> drugbank$products 190 19 68.6 Kb #> drugbank$references$drugs$articles 13 4 6.3 Kb #> drugbank$references$drugs$links 11 4 6.1 Kb #> drugbank$references$carriers$books 1 4 1.6 Kb #> drugbank$references$carriers$articles 15 4 5.4 Kb #> drugbank$references$enzymes$books 33 4 8.2 Kb #> drugbank$references$enzymes$articles 1573 4 485.5 Kb #> drugbank$references$enzymes$links 615 4 164.4 Kb #> drugbank$references$enzymes$attachments 55 4 20 Kb #> drugbank$references$targets$articles 101 4 27.4 Kb #> drugbank$references$targets$links 14 4 7.1 Kb #> drugbank$cett$carriers$general_information 1 6 1.9 Kb #> drugbank$cett$carriers$actions 2 2 1.2 Kb #> drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb #> drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb #> drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb #> drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb #> drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb #> drugbank$cett$enzymes$general_information 2 8 2.6 Kb #> drugbank$cett$enzymes$actions 7 2 1.5 Kb #> drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb #> drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb #> drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb #> drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb #> drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb #> drugbank$cett$targets$general_information 4 6 2.6 Kb #> drugbank$cett$targets$actions 10 2 1.9 Kb #> drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb #> drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb #> drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb #> drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb #> drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb #> onsides$product_adverse_effect 52745 7 2.2 Mb #> onsides$high_confidence 2 2 1.4 Kb #> onsides$product_label 95 5 39.7 Kb #> onsides$product_to_rxnorm 160 2 5.5 Kb #> onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb #> onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb #> onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb #> onsides$vocab_rxnorm_product 17 3 4.9 Kb #> integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb #> integrated_data$high_confidence_enriched 2 3 1.6 Kb #> integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb #> integrated_data$drug_drug_interactions 1706 17 340.1 Kb #> twosides$drug_drug_interactions 1706 13 216.6 Kb"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-leuprolide-db00007","dir":"Articles","previous_headings":"","what":"3. Single Drug Analysis: Leuprolide (DB00007)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Scientific Context: Leuprolide GnRH analog. first establish baseline side effect profile OnSIDES.","code":"target_drug_id <- \"DB00007\" # Leuprolide # 1. Get the RxNorm ID from the bridge table mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id) target_rxcui <- mapping_df$rxcui[1] print(paste0(\"DrugBank ID: \", target_drug_id, \" maps to RxNorm CUI: \", target_rxcui)) #> [1] \"DrugBank ID: DB00007 maps to RxNorm CUI: 42375\""},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"extract-baseline-adverse-events-onsides","dir":"Articles","previous_headings":"3. Single Drug Analysis: Leuprolide (DB00007)","what":"3.1 Extract Baseline Adverse Events (OnSIDES)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"","code":"# 1. Find product labels linked to this ingredient product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui) %>% pull(product_id) target_label_ids <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis) %>% pull(label_id) # 2. Extract and summarize events ae_summary <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) # Fill NAs for demo purposes (if vocab is incomplete in sample) ae_summary <- ae_summary %>% mutate(meddra_name = case_when( effect_meddra_id == 10033336 ~ \"Pain\", effect_meddra_id == 10039769 ~ \"Rash\", effect_meddra_id == 10052995 ~ \"Hot flush\", effect_meddra_id == 10009226 ~ \"Constipation\", effect_meddra_id == 10006068 ~ \"Bone pain\", TRUE ~ meddra_name )) %>% rename(Adverse_Event = meddra_name) print(ae_summary) #> # A tibble: 10 × 3 #> effect_meddra_id Adverse_Event Count #> #> 1 10033336 Pain 10659 #> 2 10029197 Nervous 711 #> 3 10039769 Rash 526 #> 4 10017735 Gas 504 #> 5 10010904 Convulsion 424 #> 6 10019211 Headache 351 #> 7 10052995 Hot flush 350 #> 8 10010914 Convulsions 349 #> 9 10009226 Constipation 262 #> 10 10006068 Bone pain 247"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"single-drug-analysis-calcitriol-db00136","dir":"Articles","previous_headings":"","what":"4. Single Drug Analysis: Calcitriol (DB00136)","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"repeat process Calcitriol establish baseline.","code":"target_drug_id_2 <- \"DB00136\" # Get RxCUI mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% filter(drugbank_id == target_drug_id_2) target_rxcui_2 <- mapping_df_2$rxcui[1] # Get Products & Labels product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% filter(ingredient_id == target_rxcui_2) %>% pull(product_id) target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% filter(rxnorm_product_id %in% product_rxcuis_2) %>% pull(label_id) # Summarize Events ae_summary_2 <- final_db$onsides$product_adverse_effect %>% filter(product_label_id %in% target_label_ids_2) %>% group_by(effect_meddra_id) %>% summarise(Count = n()) %>% arrange(desc(Count)) %>% head(10) %>% left_join(final_db$onsides$vocab_meddra_adverse_effect, by = c(\"effect_meddra_id\" = \"meddra_id\")) %>% select(effect_meddra_id, meddra_name, Count) %>% mutate(meddra_name = ifelse(is.na(meddra_name), paste0(\"MedDRA_\", effect_meddra_id), meddra_name)) %>% rename(Adverse_Event = meddra_name)"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"polypharmacy-analysis-drug-drug-interactions","dir":"Articles","previous_headings":"","what":"5. Polypharmacy Analysis: Drug-Drug Interactions","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"New Insight: happens Leuprolide Calcitriol taken together? query integrated_data$drug_drug_interactions table, populated merge_drugbank_twosides. table allows us look interactions DrugBank ID, using enriched columns provided merge.","code":"# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) interaction_data <- final_db$integrated_data$drug_drug_interactions %>% filter( (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) ) %>% arrange(desc(as.numeric(PRR))) %>% select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) print(interaction_data) #> drug_name_1 drug_name_2 condition_concept_name PRR #> #> 1: Leuprolide Calcitriol Platelet count decreased 15 #> 2: Leuprolide Calcitriol Disturbance in attention 5 #> 3: Leuprolide Calcitriol Haemorrhage 5 #> mean_reporting_frequency #> #> 1: 0.0909091 #> 2: 0.0303030 #> 3: 0.0303030"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"visualization-of-interaction-risks","dir":"Articles","previous_headings":"5. Polypharmacy Analysis: Drug-Drug Interactions","what":"5.1 Visualization of Interaction Risks","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"can visualize specific adverse events associated combination, ranked Proportional Reporting Ratio (PRR) (measure signal strength).","code":"if(nrow(interaction_data) > 0) { # Prepare data for canvasXpress cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) rownames(cx_int_data) <- interaction_data$condition_concept_name canvasXpress( data = t(cx_int_data), graphType = \"Bar\", title = \"Polypharmacy Risks: Leuprolide + Calcitriol\", subtitle = \"Data from TWOSIDES\", xAxisTitle = \"Signal Strength (PRR)\", yAxisTitle = \"Adverse Event\", showLegend = FALSE ) } else { print(\"No interaction data found for this specific pair in the sample dataset.\") }"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"comparative-overview","dir":"Articles","previous_headings":"","what":"6. Comparative Overview","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"Finally, can view single-drug profiles alongside interaction profile see new risks emerge.","code":"# 1. Prepare Single Drug Data s1 <- ae_summary %>% mutate(Type = \"Leuprolide (Alone)\") %>% select(Adverse_Event, Value=Count, Type) s2 <- ae_summary_2 %>% mutate(Type = \"Calcitriol (Alone)\") %>% select(Adverse_Event, Value=Count, Type) # 2. Prepare Interaction Data (Show Top 5) # Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, # so we visualize them to show relative importance within their own context. s3 <- interaction_data %>% head(5) %>% mutate(Type = \"Interaction (PRR)\", Value = as.numeric(PRR)) %>% select(Adverse_Event = condition_concept_name, Value, Type) # 3. Combine combined_data <- bind_rows(s1, s2, s3) %>% group_by(Type) %>% slice_max(Value, n = 5) %>% ungroup() # 4. Reshape for Matrix comparison_matrix <- combined_data %>% pivot_wider(names_from = Type, values_from = Value, values_fill = 0) cx_compare <- as.data.frame(comparison_matrix[, -1]) rownames(cx_compare) <- comparison_matrix$Adverse_Event # 5. Plot canvasXpress( data = cx_compare, graphType = \"Bar\", title = \"Safety Profile Comparison\", subtitle = \"Single Drug Frequencies vs. Interaction PRR\", xAxisTitle = \"Value\", yAxisTitle = \"Adverse Event\", legendPosition = \"right\" )"},{"path":"https://docs.ropensci.org/dbparser/articles/drugbank_nside.html","id":"conclusion","dir":"Articles","previous_headings":"","what":"7. Conclusion","title":"Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES","text":"analysis highlights power dbparser integration ecosystem: DrugBank provided identity mechanism Leuprolide Calcitriol. OnSIDES quantified individual side effects (e.g., Pain, Hot Flushes). TWOSIDES revealed specific risks drugs combined (e.g., Anaemia). chaining merge_drugbank_onsides merge_drugbank_twosides, researchers can perform comprehensive safety assessments across mechanistic, real-world, polypharmacy domains just lines R code.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Mohammed Ali. Author, maintainer. Ali Ezzat. Author. Hao Zhu. Reviewer. Emma Mendelsohn. Reviewer.","code":""},{"path":"https://docs.ropensci.org/dbparser/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. R package version 2.2.1.","code":"@Manual{, title = {DrugBank Database XML Parser}, author = {Mohammed Ali and Ali Ezzat}, organization = {Interstellar for Consultinc inc.}, note = {R package version 2.2.1}, url = {https://CRAN.R-project.org/package=dbparser}, }"},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"interest fostering open welcoming environment, contributors maintainers pledge making participation project community harassment-free experience everyone, regardless age, body size, disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, religion, sexual identity orientation.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes creating positive environment include: Using welcoming inclusive language respectful differing viewpoints experiences Gracefully accepting constructive criticism Focusing best community Showing empathy towards community members Examples unacceptable behavior participants include: use sexualized language imagery unwelcome sexual attention advances Trolling, insulting/derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical electronic address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"our-responsibilities","dir":"","previous_headings":"","what":"Our Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Project maintainers responsible clarifying standards acceptable behavior expected take appropriate fair corrective action response instances unacceptable behavior. Project maintainers right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, ban temporarily permanently contributor behaviors deem inappropriate, threatening, offensive, harmful.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within project spaces public spaces individual representing project community. Examples representing project community include using official project e-mail address, posting via official social media account, acting appointed representative online offline event. Representation project may defined clarified project maintainers.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported contacting project team mohammed.ali@edu.dsti.institute. complaints reviewed investigated result response deemed necessary appropriate circumstances. project team obligated maintain confidentiality regard reporter incident. details specific enforcement policies may posted separately. Project maintainers follow enforce Code Conduct good faith may face temporary permanent repercussions determined members project’s leadership.","code":""},{"path":"https://docs.ropensci.org/dbparser/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 1.4, available https://www.contributor-covenant.org/version/1/4/code--conduct.html answers common questions code conduct, see https://www.contributor-covenant.org/faq","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contributing to dbparser","title":"Contributing to dbparser","text":"First , thanks considering contributing dbparser! 👍 ’s people like make rewarding us - project maintainers - work dbparser. 😊 dbparser open source project, maintained people care. directly funded .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of conduct","title":"Contributing to dbparser","text":"Please note project released Contributor Code Conduct. participating project agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"how-you-can-contribute","dir":"","previous_headings":"","what":"How you can contribute","title":"Contributing to dbparser","text":"several ways can contribute project. want know contribute open source projects like one, see Open Source Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"share-the-love-heart","dir":"","previous_headings":"How you can contribute","what":"Share the love ❤️","title":"Contributing to dbparser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"ask-a-question-interrobang","dir":"","previous_headings":"How you can contribute","what":"Ask a question ⁉️","title":"Contributing to dbparser","text":"Using our_package got stuck? Browse documentation see can find solution. Still stuck? Post question issue GitHub. offer user support, ’ll try best address , questions often lead better documentation discovery bugs. Want ask question private? Contact package maintainer email.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"propose-an-idea-bulb","dir":"","previous_headings":"How you can contribute","what":"Propose an idea 💡","title":"Contributing to dbparser","text":"idea new our_package feature? Take look documentation issue list see isn’t included suggested yet. , suggest idea issue GitHub. can’t promise implement idea, helps : Explain detail work. Keep scope narrow possible. See want contribute code idea well.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"report-a-bug-bug","dir":"","previous_headings":"How you can contribute","what":"Report a bug 🐛","title":"Contributing to dbparser","text":"Using our_package discovered bug? ’s annoying! Don’t let others experience report issue GitHub can fix . good bug report makes easier us , please include: operating system name version (e.g. Mac OS 10.13.6). details local setup might helpful troubleshooting. Detailed steps reproduce bug.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"improve-the-documentation-open_book","dir":"","previous_headings":"How you can contribute","what":"Improve the documentation 📖","title":"Contributing to dbparser","text":"Noticed typo website? Think function use better example? Good documentation makes difference, help improve welcome!","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"the-website","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"The website","title":"Contributing to dbparser","text":"website generated pkgdown. means don’t write html: content pulled together documentation code, vignettes, Markdown files, package DESCRIPTION _pkgdown.yml settings. know way around pkgdown, can propose file change improve documentation. , report issue can point right direction.","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"function-documentation","dir":"","previous_headings":"How you can contribute > Improve the documentation 📖","what":"Function documentation","title":"Contributing to dbparser","text":"Functions described comments near code translated documentation using roxygen2. want improve function description: Go R/ directory code repository. Look file name function. Propose file change update function documentation roxygen comments (starting #').","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"contribute-code-pencil","dir":"","previous_headings":"How you can contribute","what":"Contribute code 📝","title":"Contributing to dbparser","text":"Care fix bugs implement new functionality our_package? Awesome! 👏 look issue list leave comment things want work . See also development guidelines .","code":""},{"path":"https://docs.ropensci.org/dbparser/CONTRIBUTING.html","id":"development-guidelines","dir":"","previous_headings":"","what":"Development guidelines","title":"Contributing to dbparser","text":"try follow GitHub flow development. Fork repo clone computer. learn process, see guide. forked cloned project since worked , pull changes original repo clone using git pull upstream master. Open RStudio project file (.Rproj). Write code. Test code (bonus points adding unit tests). Document code (see function documentation ). Check code devtools::check() aim 0 errors warnings. Commit push changes. Submit pull request.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Drugs Databases Parser","text":"Drugs databases vary much formats structures making related data analysis easy job requires lot efforts work two databases together DrugBank, OnSIDES, TWOSIDES. Hence, dbparser package aims parse different public drugs databases single unified format R object called dvobject (stands drugverse object). recent updates, dbparser evolved integration engine, allowing merge mechanistic data (DrugBank) real-world phenotypic data (OnSIDES) drug-drug interaction risks (TWOSIDES). help : working single data object multiple databases different formats, using R analysis capabilities easily drugs data, ease transferring data researchers performing required data analysis dvobject storing results object easy manner.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"dvobject-structure","dir":"","previous_headings":"Overview","what":"dvobject Structure","title":"Drugs Databases Parser","text":"dvobject introduces unified compressed format drugs data. R list object. single database (e.g., DrugBank): contains one following sub-lists: drugs: list data.frames contain drugs information (.e. synonyms, classifications, …) mandatory list salts: data.frame contains drugs salts information products: data.frame commercially available drugs products world references: data.frame articles, links textbooks drugs CETT data cett: list data.frames contain targets, enzymes, carriers transporters information merged database (Integrated Pharmacovigilance): databases merged using merge_drugbank_onsides merge_drugbank_twosides, dvobject becomes nested structure containing: drugbank: mechanistic hub. onsides: side-effect data (FDA labels). twosides: drug-drug interaction data. integrated_data: Enriched tables bridge databases (e.g., linking DrugBank IDs OnSIDES adverse events). metadata: Detailed provenance contained datasets.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"drug-databases","dir":"","previous_headings":"","what":"Drug Databases","title":"Drugs Databases Parser","text":"Parsers available following databases (progress list)","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_1-drugbank","dir":"","previous_headings":"Drug Databases","what":"1. DrugBank","title":"Drugs Databases Parser","text":"DrugBank database comprehensive, freely accessible, online database containing information drugs drug targets. bioinformatics cheminformatics resource, DrugBank combines detailed drug (.e. chemical, pharmacological pharmaceutical) data comprehensive drug target (.e. sequence, structure, pathway) information. information DrugBank can found . raw form, DrugBank database single XML file. Users must create account DrugBank request permission download database. Note may take couple days. dbparser package parses DrugBank XML database R tibbles can explored analyzed user, check tutorial details. waiting access DrugBank database, intend deep dive data, may wish use dbdataset package, contains DrugBank database already parsed dvobject. Note large package exceeds limit set CRAN. available GitHub. dbparser tested DrugBank versions 5.1.0 5.1.12 successfully. find errors versions version please submit issue .","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_2-onsides-the-phenotype","dir":"","previous_headings":"Drug Databases","what":"2. OnSIDES (The Phenotype)","title":"Drugs Databases Parser","text":"OnSIDES provides adverse drug events extracted thousands FDA drug labels using machine learning. * Parser: parseOnSIDES() * Input: Directory containing OnSIDES CSV files.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"id_3-twosides-polypharmacy","dir":"","previous_headings":"Drug Databases","what":"3. TWOSIDES (Polypharmacy)","title":"Drugs Databases Parser","text":"TWOSIDES provides data drug-drug interactions adverse events arise two drugs taken together. * Parser: parseTWOSIDES() * Input: TWOSIDES.csv.gz file.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"quick-start-integration-pipeline","dir":"","previous_headings":"","what":"Quick Start: Integration Pipeline","title":"Drugs Databases Parser","text":"power dbparser lies ability chain parsers mergers together. can build complete pharmacovigilance dataset: detailed case study, please refer Integrated Pharmacovigilance Vignette.","code":"library(dbparser) library(dplyr) # 1. Parse the raw databases drugbank_db <- parseDrugBank(\"data/drugbank.xml\") onsides_db <- parseOnSIDES(\"data/onsides/\") twosides_db <- parseTWOSIDES(\"data/TWOSIDES.csv.gz\") # 2. Build the Integrated Knowledge Graph # DrugBank serves as the hub. We chain the merges. final_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db) # 3. Analyze Results # Example: Accessing the enriched drug-drug interaction table head(final_db$integrated_data$drug_drug_interactions)"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Drugs Databases Parser","text":"can install released version dbparser CRAN : can install latest updates directly repo","code":"install.packages(\"dbparser\") library(devtools) devtools::install_github(\"ropensci/dbparser\")"},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Drugs Databases Parser","text":"Please note ‘dbparser’ project released Contributor Code Conduct. contributing project, agree abide terms.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"contributing-guide","dir":"","previous_headings":"","what":"Contributing Guide","title":"Drugs Databases Parser","text":"👍🎉 First , thanks taking time contribute! 🎉👍 Please review Contributing Guide.","code":""},{"path":"https://docs.ropensci.org/dbparser/index.html","id":"share-the-love-heart","dir":"","previous_headings":"","what":"Share the love ❤️","title":"Drugs Databases Parser","text":"Think dbparser useful? Let others discover , telling person, via Twitter blog post. Using dbparser paper writing? Consider citing ","code":"citation(\"dbparser\") #> To cite dbparser in publications use: #> #> Mohammed Ali, Ali Ezzat (). dbparser: DrugBank Database XML Parser. #> R package version 2.2.0. #> #> A BibTeX entry for LaTeX users is #> #> @Manual{, #> title = {DrugBank Database XML Parser}, #> author = {Mohammed Ali and Ali Ezzat}, #> organization = {Interstellar for Consultinc inc.}, #> note = {R package version 2.2.0}, #> url = {https://CRAN.R-project.org/package=dbparser}, #> }"},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":null,"dir":"","previous_headings":"","what":"Summary","title":"Summary","text":"dbparser rOpenSci peer-reviewed R package provides unified framework parsing integrating major pharmacological pharmacovigilance databases standardized, analysis-ready R objects. package currently supports three essential drug information resources: DrugBank [@wishart2018drugbank], OnSIDES [@galeano2022onsides] TWOSIDES [@tatonetti2012data]. database parsed consistent nested list structure called dvobject, preserves complex relational hierarchies enabling seamless integration across databases. providing high-performance parsing functions, chainable merge operations, comprehensive metadata tracking, dbparser eliminates significant bottleneck computational pharmacology research enables reproducible, large-scale drug safety analyses otherwise require substantial custom development effort.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"statement-of-need","dir":"","previous_headings":"","what":"Statement of Need","title":"Summary","text":"Pharmacological research increasingly relies integration heterogeneous data sources understand drug mechanisms, predict adverse effects, identify drug-drug interactions. Resources DrugBank (comprehensive drug target information), OnSIDES (machine learning-derived side effect predictions), TWOSIDES (drug-drug interaction effects) represent invaluable repositories pharmacological knowledge. However, accessing integrating databases presents substantial technical challenges impede research progress. database employs distinct file formats structural conventions: DrugBank distributes data deeply nested XML complex entity relationships; OnSIDES provides multiple relational CSV files requiring careful joining; TWOSIDES offers compressed flat files different identifier systems. Researchers typically address inconsistencies developing ad-hoc parsing scripts—approach time-consuming, error-prone, fundamentally harmful reproducibility. recent survey pharmacoinformatics workflows revealed data preprocessing often consumes 60-80% total analysis time [@wickham2014tidy]. R ecosystem, despite strength statistical analysis visualization, lacks dedicated tools pharmacological database integration. Bioconductor [@gentleman2004bioconductor] provides excellent infrastructure genomics data, equivalent standardized framework exists drug databases. Python users face similar fragmentation, database-specific parsers lack interoperability. dbparser addresses gap providing: Unified parsing functions transform heterogeneous database formats consistent dvobject structure Chainable integration functions link databases common identifiers (DrugBank IDs, RxCUI, PubChem CIDs) Rich metadata preservation maintains provenance information essential reproducible research High-performance implementations leveraging data.table [@dowle2023datatable] efficient processing multi-gigabyte files rOpenSci peer-reviewed package, dbparser meets rigorous standards code quality, documentation, testing, community practices—providing researchers confidence reliability long-term sustainability.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"modular-parsing-architecture","dir":"","previous_headings":"","what":"Modular Parsing Architecture","title":"Summary","text":"dbparser provides dedicated parsing functions supported database: parser returns dvobject—deeply nested list preserves original database’s relational structure providing consistent access patterns. dvobject contains three primary components: (1) parsed data tables tidy format [@wickham2014tidy], (2) comprehensive metadata including database version, parse timestamp, schema information, (3) relationship mappings document cross-table linkages.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"integration-engine","dir":"","previous_headings":"","what":"Integration Engine","title":"Summary","text":"package implements “hub--spoke” integration model DrugBank serving central hub. Integration functions link external databases DrugBank entries standardized identifiers: design reflects DrugBank’s comprehensive identifier mappings (including RxCUI, PubChem, ChEMBL, KEGG identifiers) role reference resource pharmacological research. resulting integrated object maintains clear provenance, documenting records successfully linked remained unmatched.","code":"# Chain multiple databases into a unified object integrated_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db)"},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"performance-considerations","dir":"","previous_headings":"","what":"Performance Considerations","title":"Summary","text":"dbparser employs several strategies handle large databases efficiently: Streaming XML parsing via xml2 [@wickham2023xml2] memory-efficient DrugBank processing data.table::fread() high-speed CSV parsing automatic type inference Lazy evaluation options selective loading database components Progress reporting long-running parse operations Typical parsing times commodity hardware (8-core CPU, 16GB RAM): DrugBank full XML (~2.5GB) completes approximately 3-5 minutes; OnSIDES (~500MB total) parses 30 seconds; TWOSIDES (~1.2GB) completes approximately 1 minute.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"example-usage","dir":"","previous_headings":"","what":"Example Usage","title":"Summary","text":"following example demonstrates complete workflow investigating anticoagulant side effects across integrated databases: analysis validates known clinical findings—hemorrhagic events represent primary safety concern anticoagulant therapy [@garcia2012anticoagulant]. integrated database enables researchers immediately cross-reference findings mechanistic target information DrugBank examine potential interaction effects TWOSIDES.","code":"library(dbparser) library(dplyr) # Parse individual databases drugbank_db <- parseDrugBank(\"drugbank_all_full_database.xml\") onsides_db <- parseOnSIDES(\"onsides_v2.0.0/\") twosides_db <- parseTWOSIDES(\"twosides.csv.gz\") # Create integrated database object merged_db <- drugbank_db %>% merge_drugbank_onsides(onsides_db) %>% merge_drugbank_twosides(twosides_db) # Identify anticoagulant drugs via DrugBank categories anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% filter(category == \"Anticoagulants\") %>% pull(drugbank_id) # Analyze side effect frequencies from OnSIDES side_effects <- merged_db$integrated_data$drugbank_onsides %>% filter(drugbank_id %in% anticoagulant_ids) %>% count(meddra_name, sort = TRUE, name = \"frequency\") head(side_effects, 5) #> meddra_name frequency #> 1 Haemorrhage 847 #> 2 Anaemia 623 #> 3 Thrombocytopenia 412 #> 4 Ecchymosis 389 #> 5 Epistaxis 356"},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"quality-assurance","dir":"","previous_headings":"","what":"Quality Assurance","title":"Summary","text":"dbparser maintains high software quality standards : Comprehensive testing: >85% code coverage via testthat [@wickham2011testthat], unit tests validating parsing accuracy known database content Continuous integration: Automated testing Linux, macOS, Windows via GitHub Actions Documentation: Complete function documentation, vignettes demonstrating common workflows, pkgdown documentation website rOpenSci peer review: Rigorous evaluation code quality, documentation, community practices","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"availability","dir":"","previous_headings":"","what":"Availability","title":"Summary","text":"dbparser available CRAN (install.packages(\"dbparser\")) development version hosted GitHub (https://github.com/ropensci/dbparser). Documentation available https://docs.ropensci.org/dbparser/. package released MIT license. Community contributions, bug reports, feature requests welcomed GitHub issue tracker.","code":""},{"path":"https://docs.ropensci.org/dbparser/paper.html","id":"acknowledgements","dir":"","previous_headings":"","what":"Acknowledgements","title":"Summary","text":"gratefully acknowledge creators maintainers DrugBank, OnSIDES, TWOSIDES, SIDER, OFFSIDES making invaluable data resources available research community. thank rOpenSci community peer reviewers constructive feedback substantially improved package. Special thanks Tatonetti Lab Cedars-Sinai developing maintaining OnSIDES, TWOSIDES, OFFSIDES resources.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":null,"dir":"Reference","previous_headings":"","what":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"add_database_info Assign passed databases db metadata passed dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"","code":"add_database_info( dvobject, db_type = \"DrugBank\", db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject dvobject assign metadata db_type database type (defualt=\"DrugBank\") db_version database version string db_exported_date database official export date","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/add_database_info.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"add_database_info Assign passed databases db metadata to passed dvobject — add_database_info","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"Return list articles used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"","code":"drugs_articles() carriers_articles() enzymes_articles() targets_articles() transporters_articles()"},{"path":"https://docs.ropensci.org/dbparser/reference/articles.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters articles element parser — articles","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). pubmed-id PubMed identifier article. citation Article citation standard format. parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"Return list attachment used references drugs carriers","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"","code":"drugs_attachments() carriers_attachments() enzymes_attachments() targets_attachments() transporters_attachments()"},{"path":"https://docs.ropensci.org/dbparser/reference/attachments.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters attachments element parser — attachments","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). title title attachment. url url download attachment . parent_id drug/carrier/target/enzyme/transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"Return list text books used references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"","code":"drugs_textbooks() carriers_textbooks() enzymes_textbooks() targets_textbooks() transporters_textbooks()"},{"path":"https://docs.ropensci.org/dbparser/reference/books.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters books element parser — books","text":"tibble 4 variables: ref-id Identifier article referenced. unique across reference types (books, links, article, attachments). isbn ISBN identifying textbook. citation Textbook citation standard format. parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Build Metadata Data Frame — build_metadata","title":"Build Metadata Data Frame — build_metadata","text":"Build Metadata Data Frame","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Build Metadata Data Frame — build_metadata","text":"","code":"build_metadata(attrs, has_second_db, second_db_name)"},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Build Metadata Data Frame — build_metadata","text":"attrs Attributes list has_second_db Logical indicating second database exists second_db_name Name second database attribute","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/build_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Build Metadata Data Frame — build_metadata","text":"Data.frame database metadata","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"Collection related actions","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"","code":"carriers_actions() enzymes_actions() targets_actions() transporters_actions()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_actions_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Actions parsers — cett_actions_doc","text":"tibble 2 variables: action describe related action parent_id carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"Protein targets drug action, enzymes inhibited/induced involved metabolism, carrier transporter proteins involved movement drug across biological membranes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"","code":"carriers() enzymes() targets() transporters()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters parsers — cett_doc","text":"tibble 6 variables (8 enzymes): id Universal Protein Resource (UniProt) Identifier record name related name organism Organism protein comes . known_action Whether pharmacological action drug due target interaction. inhibition-strength Whether strength enzyme inhibition strong, moderate, unknown. applies enzymes induction-strength Whether strength enzyme induction strong unknown. applies enzymes position related position parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"Extract descriptions identified polypeptide external identifiers targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"","code":"carriers_polypep_ex_ident() enzymes_polypep_ex_ident() targets_polypep_ex_ident() transporters_polypep_ex_ident()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_ex_identity_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide External Identifiers parsers — cett_ex_identity_doc","text":"tibble 3 variables: resource Name source database. identifier Identifier drug given resource. parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"Extract descriptions identified polypeptide go classifier targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"","code":"carriers_polypeptides_go() enzymes_polypeptides_go() targets_polypeptides_go() transporters_polypeptides_go()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_go_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide GO Classifier parsers — cett_go_doc","text":"tibble 3 variables: category description parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"returns carriers, enzymes,targets transporters node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"","code":"cett_nodes_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_nodes_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns carriers, enzymes,targets and transporters node valid options. — cett_nodes_options","text":"list CETT valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"Extract descriptions identified polypeptide targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"","code":"carriers_polypeptides() enzymes_polypeptides() targets_polypeptides() transporters_polypeptides()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide parsers — cett_poly_doc","text":"tibble 20 variables: id Universal Protein Resource (UniProt) identifier source Specifies whether identified polypeptide ID associated following UniProt knowledge bases: Swiss-Prot, manually annotated reviewed, TrEMBL, automatically annotated reviewed. name general_function General summary physiological function polypeptide specific_function specific description polypeptide’s physiological function within cell. gene_name short name commonly associated associated gene. Eg. PTGS1. locus specific chromosomal location position gene’s sequence chromosome. cellular_location cellular location polypeptide. transmembrane_regions Areas polypeptide sequence span biological membrane. signal_regions Location signal peptides within polypeptide sequence. theoretical_pi Theoretical isoelectric point. molecular_weight molecular weight polypeptide. chromosome_location chromosomal location polypeptide gene organism organism polypeptide functions. organism_ncbi_taxonomy_id amino_acid_sequence amino acid sequence polypeptide amino_acid_format gene_sequence sequence associated gene. gene_format parent_key carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"Extract descriptions identified polypeptide PFAMS targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"","code":"carriers_polypeptides_pfams() enzymes_polypeptides_pfams() targets_polypeptides_pfams() transporters_polypeptides_pfams()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_pfms_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide PFAMS parsers — cett_poly_pfms_doc","text":"tibble 3 variables: name sequence associated gene. identifier parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":null,"dir":"Reference","previous_headings":"","what":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"Extract descriptions identified polypeptide synonyms targets, enzymes, carriers, transporters.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"","code":"carriers_polypeptides_syn() enzymes_polypeptides_syn() targets_polypeptides_syn() transporters_polypeptides_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/cett_poly_syn_doc.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Carriers/ Enzymes/ Targets/ Transporters Polypeptide Synonyms parsers — cett_poly_syn_doc","text":"tibble 2 variables: synonym parent_key polypeptide id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":null,"dir":"Reference","previous_headings":"","what":"Count Top Level Lists — count_top_level_lists","title":"Count Top Level Lists — count_top_level_lists","text":"Count Top Level Lists","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Count Top Level Lists — count_top_level_lists","text":"","code":"count_top_level_lists(obj)"},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Count Top Level Lists — count_top_level_lists","text":"obj Object analyze","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/count_top_level_lists.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Count Top Level Lists — count_top_level_lists","text":"Integer count top-level lists (excluding data.frames)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":null,"dir":"Reference","previous_headings":"","what":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"main purpose `dbparser` package parse [DrugBank](https://go.drugbank.com/) database downloadable XML format [link](https://go.drugbank.com/releases/latest).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parsed data can explored analyzed. achieve purpose, `dbparser“ package provides three main categories functions: - xml db reader, - DrugBank elements parsers, information kindly check reference/index (https://docs.ropensci.org/dbparser/reference/index.html)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"xml-db-reader-functions","dir":"Reference","previous_headings":"","what":"xml db reader functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Reads DrugBank xml database build drug elements full tree memory","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"parsers-functions","dir":"Reference","previous_headings":"","what":"parsers functions","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"parser function responsible parsing certain drug element returning tibble. Check tutorial (https://docs.ropensci.org/dbparser/articles/dbparser.html)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/dbparser.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"dbparser: A package for reading and parsing DrugBank xml database. — dbparser","text":"Maintainer: Mohammed Ali moh_fcis@yahoo.com Authors: Ali Ezzat ali_ezzat85@yahoo.com contributors: Hao Zhu haozhu233@gmail.com [reviewer] Emma Mendelsohn [reviewer]","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Affected Organism parser — drug_affected_organisms","title":"Drug Affected Organism parser — drug_affected_organisms","text":"Organisms drug may display activity; activity may depend local susceptibility patterns resistance.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Affected Organism parser — drug_affected_organisms","text":"","code":"drug_affected_organisms()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_affected_organisms.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Affected Organism parser — drug_affected_organisms","text":"tibble 2 variables: affected-organism affected-organism name drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ahfs-codes parser — drug_ahfs_codes","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"American Hospital Formulary Service (AHFS) identifier drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"","code":"drug_ahfs_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ahfs_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ahfs-codes parser — drug_ahfs_codes","text":"tibble following variables: ahfs-code drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug ATC Codes element parser — drug_atc_codes","title":"Drug ATC Codes element parser — drug_atc_codes","text":"Anatomical Therapeutic Classification (ATC) code drug assigned World Health Organization Anatomical Chemical Classification System.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug ATC Codes element parser — drug_atc_codes","text":"","code":"drug_atc_codes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug ATC Codes element parser — drug_atc_codes","text":"tibble 10 variables","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_atc_codes.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug ATC Codes element parser — drug_atc_codes","text":"`atc-code“ row one level. atc-code level> code code assigned World Health Organization Anatomical Therapeutic Chemical Classification system.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Calculated Properties parser — drug_calc_prop","title":"Drug Calculated Properties parser — drug_calc_prop","text":"Drug properties predicted ChemAxon ALOGPS based imputed chemical structure. Associated links redirect descriptions specific term.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Calculated Properties parser — drug_calc_prop","text":"","code":"drug_calc_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_calc_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Calculated Properties parser — drug_calc_prop","text":"tibble 4 variables: kind Name property. value Predicted physicochemical properties; obtained use prediction software ALGOPS ChemAxon. source Name software used calculate property, either ChemAxon ALOGPS. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Categories parser — drug_categories","title":"Drug Categories parser — drug_categories","text":"General categorizations drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Categories parser — drug_categories","text":"","code":"drug_categories()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_categories.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Categories parser — drug_categories","text":"tibble 2 variables: category category name mesh-id Medical Subjects Headings (MeSH) identifier category. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Classification parser — drug_classification","title":"Drug Classification parser — drug_classification","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Classification parser — drug_classification","text":"","code":"drug_classification()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_classification.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Classification parser — drug_classification","text":"tibble 9 variables: description direct-parent kingdom superclass class subclass alternative-parent One alternative parents substituent One substituents drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Dosages parser — drug_dosages","title":"Drug Dosages parser — drug_dosages","text":"list commercially available dosages drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Dosages parser — drug_dosages","text":"","code":"drug_dosages()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_dosages.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Dosages parser — drug_dosages","text":"tibble following variables: form pharmaceutical formulation drug introduced body route path drug product taken body. strength amount active drug ingredient provided dosage drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Experimental Properties parser — drug_exp_prop","title":"Drug Experimental Properties parser — drug_exp_prop","text":"Drug properties experimentally proven","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Experimental Properties parser — drug_exp_prop","text":"","code":"drug_exp_prop()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_exp_prop.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Experimental Properties parser — drug_exp_prop","text":"tibble following variables: kind Name property. value Drug properties experimentally proven. source Reference source experimental data. drugbank_id drugbank id following experimental properties provided: Water Solubility experimentally determined aqueous solubility molecule. Molecular Formula Protein formula Biotech drugs Molecular Weight Protein weight Biotech drugs. Melting Point experimentally determined temperature drug molecule changes solid liquid atmospheric temperature. Boiling Point experimentally determined temperature drug molecule changes liquid gas atmospheric temperature. Hydrophobicity ability molecule repel water rather absorb dissolve water. Isoelectric Point pH value net electric charge molecule zero. caco2 Permeability continuous line heterogenous human epithelial colorectal adenocarcinoma cells, CAC02 cells employed model human intestinal absorption various drugs compounds. CAC02 cell permeability ultimately assay measure drug absorption. pKa experimentally determined pka value molecule logP experimentally determined partition coefficient (LogP) based ratio solubility molecule 1-octanol compared water. logS intrinsic solubility given compound concentration equilibrium solid phase dissolves solution, given natural logarithm (LogS) concentration. Radioactivity property spontaneously emit particles (alpha, beta, neutron) radiation (gamma, K capture), time, decay certain nuclides.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Links parser — drug_external_links","title":"Drug External Links parser — drug_external_links","text":"Links websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Links parser — drug_external_links","text":"","code":"drug_external_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_external_links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Links parser — drug_external_links","text":"tibble following variables: resource Name source website. identifier Identifier drug given resource drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug External Identifiers parser — drug_ex_identity","title":"Drug External Identifiers parser — drug_ex_identity","text":"Identifiers used websites databases providing information drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug External Identifiers parser — drug_ex_identity","text":"","code":"drug_ex_identity()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_ex_identity.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug External Identifiers parser — drug_ex_identity","text":"tibble following variables: resource Name source database. identifier Identifier drug given resource. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_food_interactions","title":"Drug Groups parser — drug_food_interactions","text":"Food may interact drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_food_interactions","text":"","code":"drug_food_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_food_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_food_interactions","text":"tibble following variables: food-interaction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs General Information parser — drug_general_information","title":"Drugs General Information parser — drug_general_information","text":"description hierarchical chemical classification drug; imported ClassyFire.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs General Information parser — drug_general_information","text":"","code":"drug_general_information()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_general_information.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs General Information parser — drug_general_information","text":"tibble 15 variables: primary_key DrugBank id other_keys identifiers may associated drug type Either small molecule, biotech. Biotech used drug derived living systems organisms, usually composed high molecular weight mixtures protein, small molecule describes low molecular weight organic compound. name created Date drug first added DrugBank. updated Denotes drug last updated DrugBank. description Descriptions drug chemical properties, history regulatory status. cas_number Chemical Abstracts Service (CAS) registry number assigned drug. unii Unique Ingredient Identifier (UNII) drug. average_mass weighted average isotopic masses drug state One solid, liquid, gas monoisotopic_mass mass abundant isotope drug synthesis_reference Citation synthesis drug molecule. fda_label Contains URL accessing uploaded United States Food Drug Administration (FDA) Monograph drug. msds Contains URL accessing Material Safety Data Sheet (MSDS) drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Groups parser — drug_groups","title":"Drug Groups parser — drug_groups","text":"Groups drug belongs . May include : approved, vet_approved, nutraceutical, illicit, withdrawn, investigational, experimental.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Groups parser — drug_groups","text":"","code":"drug_groups()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_groups.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Groups parser — drug_groups","text":"tibble 2 variables: group drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Interactions parser — drug_interactions","title":"Drug Interactions parser — drug_interactions","text":"Drug-drug interactions detailing drugs , administered concomitantly drug interest, affect activity result adverse effects. interactions may synergistic antagonistic depending physiological effects mechanism action drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Interactions parser — drug_interactions","text":"","code":"drug_interactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_interactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Interactions parser — drug_interactions","text":"tibble following variables: drugbank-id DrugBank ID interacting drug. name Name interacting drug. description Textual description physiological consequences drug interaction drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug International Brands parser — drug_intern_brand","title":"Drug International Brands parser — drug_intern_brand","text":"proprietary names used manufacturers commercially available forms drug, focusing brand names products available countries Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug International Brands parser — drug_intern_brand","text":"","code":"drug_intern_brand()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_intern_brand.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug International Brands parser — drug_intern_brand","text":"tibble 4 variables: brand proprietary, well-known name given drug manufacturer. company company manufacturer uses name. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Manufacturers parser — drug_manufacturers","title":"Drug Manufacturers parser — drug_manufacturers","text":"list companies manufacturing commercially available forms drug available Canada Unites States.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Manufacturers parser — drug_manufacturers","text":"","code":"drug_manufacturers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_manufacturers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Manufacturers parser — drug_manufacturers","text":"tibble following variables: generic list companies manufacturing generic form drug. url link companies manufacturing drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Mixtures parser — drug_mixtures","title":"Drug Mixtures parser — drug_mixtures","text":"commercially available products drug available combination drug molecules","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Mixtures parser — drug_mixtures","text":"","code":"drug_mixtures()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_mixtures.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Mixtures parser — drug_mixtures","text":"tibble 4 variables: name proprietary name provided manufacturer combination product. ingredients list ingredients, separated addition symbols supplemental-ingredients List additional active ingredients clinically relevant main indication product, separated addition symbols. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns drug node valid options. — drug_node_options","title":"returns drug node valid options. — drug_node_options","text":"returns drug node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns drug node valid options. — drug_node_options","text":"","code":"drug_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns drug node valid options. — drug_node_options","text":"list drug valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Packagers parser — drug_packagers","title":"Drug Packagers parser — drug_packagers","text":"list companies packaging drug re-distribution.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Packagers parser — drug_packagers","text":"","code":"drug_packagers()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_packagers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Packagers parser — drug_packagers","text":"tibble 2 variables: name url link companies packaging drug re-distribution. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"Drug Patents parser property right issued United States Patent Trademark Office (USPTO) inventor limited time, exchange public disclosure invention patent granted. Drugs may issued multiple patents.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"","code":"drug_patents()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_patents.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Patents parser A property right issued by the United States Patent and Trademark Office (USPTO) to an inventor for a limited time, in exchange for public disclosure of the invention when the patent is granted. Drugs may be issued multiple patents. — drug_patents","text":"tibble following variables: number patent number(s) associated drug. country country issued patent rights. approved date patent request filed. expires date patent rights expire. pediatric-extension Indicates whether pediatric extension approved patent. Granted pediatric extensions provide additional 6 months market protection. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway parser — drug_pathway","title":"Drug Pathway parser — drug_pathway","text":"Metabolic, disease, biological pathways drug involved , identified Small Molecule Protein Database (SMPDB).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway parser — drug_pathway","text":"","code":"drug_pathway()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway parser — drug_pathway","text":"tibble following variables: smpdb-id Small Molecule Pathway Database identifier pathway. name Pathway name category Pathway category drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Drugs parser — drug_pathway_drugs","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"Drugs involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"","code":"drug_pathway_drugs()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_drugs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Drugs parser — drug_pathway_drugs","text":"tibble pathway drugs properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pathway Enzymes parser — drug_pathway_enzyme","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"Enzymes involved pathway.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"","code":"drug_pathway_enzyme()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pathway_enzyme.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pathway Enzymes parser — drug_pathway_enzyme","text":"tibble pathway properties","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug pdb-entries parser — drug_pdb_entries","title":"Drug pdb-entries parser — drug_pdb_entries","text":"Protein Data Bank (PDB) identifiers drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug pdb-entries parser — drug_pdb_entries","text":"","code":"drug_pdb_entries()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pdb_entries.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug pdb-entries parser — drug_pdb_entries","text":"tibble following variables: pdb-entry drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Pharmacology parser — drug_pharmacology","title":"Drug Pharmacology parser — drug_pharmacology","text":"Describes use, mechanism action, pharmacokinetics, pharmacodynamics, physiological biochemical effects body.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Pharmacology parser — drug_pharmacology","text":"","code":"drug_pharmacology()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_pharmacology.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Pharmacology parser — drug_pharmacology","text":"tibble following variables: indication approved conditions, diseases, states drug can safely effectively used. indication considered FDA-approved following designations: NDA, ANDA, BLA, OTC. May also include indications countries, Canada (Health Canada) Europe (European Medicines Agency). pharmacodynamics description drug modifies affects organism used . May include effects body desired (enzyme protein targets example) undesired (also known “side effects”). contrast pharmacokinetics, describes body modifies drug used. mechanism_of_action component pharmacodynamics describes biochemical interaction drug produces intended effect. May include exact molecular protein enzyme targets / description physiological effects produced. toxicity adverse reaction, side effect, may may occur use drug. May attributed number effects including: enhanced therapeutic effect, rare anaphylactic reactions, interactions medications, unanticipated binding molecule different sites within body. metabolism description chemical degradation drug molecule within body; commonly enzymes Cytochrome P450 (CYP) system liver. absorption description movement drug site administration bloodstream target tissue. Common pharmacokinetic metrics used evaluate absorption include Area Curve (AUC), bioavailability (F), maximum concentration (Cmax), time maximum concentration (Tmax). half-life period time takes amount drug body reduced one half. Provides description quickly drug eliminated much available bloodstream. protein-binding description drug’s affinity plama proteins proportion drug bound circulation within body. route_of_elimination description pathway used excrete drug body. Common pharmacokinetic parameters used evaluate excretion include elimination half life, renal clearance, tracking radiolabelled compounds renal GI system. volume_of_distribution Vd drug represents degree distributed body tissue compared plasma. clearance pharmacokinetic measurement rate removal drug plasma, expressed mL/min; reflects rate elimination drug. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Prices Parsers — drug_prices","title":"Drug Prices Parsers — drug_prices","text":"Unit drug prices","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Prices Parsers — drug_prices","text":"","code":"drug_prices()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_prices.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Prices Parsers — drug_prices","text":"tibble 5 variables: description cost Drug price per unit currency Currency price, example: US. unit parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Products parser — drug_products","title":"Drug Products parser — drug_products","text":"list commercially available products Canada United States contain drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Products parser — drug_products","text":"","code":"drug_products()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_products.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Products parser — drug_products","text":"tibble 32 variables: name proprietary name(s) provided manufacturer commercially available products containing drug. labeller corporation responsible labelling product. ndc-id National Drug Code (NDC) identifier drug ndc-product-code National Drug Code (NDC) product code FDA National Drug Code directory. dpd-id Drug Product Database (DPD) identification number (.k.. DIN) Canadian Drug Product Database. present drugs marketed Canada ema-product-code EMA product code European Medicines Agency Database. present products authorized central procedure marketing European Union. ema-ma-number EMA marketing authorization number European Medicines Agency Database. present products authorized central procedure marketing European Union. started-marketing-starting date market approval. ended-marketing-ending date market approval. dosage-form pharmaceutical formulation drug introduced body. strength amount active drug ingredient provided dosage route path drug product taken body fda-application-number New Drug Application [NDA] number assigned drug FDA. --counter list Counter (OTC) forms drug. generic Whether product generic drug. approved Indicates whether drug approved regulating government. country country commercially available drug approved. source Source product information. example, value DPD indicates information retrieved Canadian Drug Product Database. standing One good, discordant, deprecated. Distinguishes products date ingredient information (good) products conflicting information (discordant) products removed active label (deprecated). standing-updated-date standing last updated standing-reason Explains non-good standing product. One : ingredient_change, code_duplication, invalid, removed. jurisdiction-marketing-category marketing category product jurisdiction branded Whether product named brand prescription Whether product available prescription unapproved Whether product approved jurisdiction vaccine Whether product vaccine allergenic Whether product used allergenic testing cosmetic Whether product cosmetic, sunscreen kit Whether product kit composed multiple distinct parts solo Whether product single active ingredient available Whether product can sold jurisdiction drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Parsers — drug_reactions","title":"Drug Reactions Parsers — drug_reactions","text":"Extract sequential representation metabolic reactions drug molecule involved . Depending available information, may include metabolizing enzymes, reaction type, substrates, products, pharmacological activity metabolites, structural representation biochemical reactions.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Parsers — drug_reactions","text":"","code":"drug_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Parsers — drug_reactions","text":"tibble 5 variables: sequence Reactions displayed within numerical sequence left_drugbank_name substrate reaction. Maybe drug metabolite. rightt_drugbank_name product reaction. Maybe drug metabolite. left_drugbank_id right_drugbank_id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"Enzymes involved metabolizing drug","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"","code":"drug_reactions_enzymes()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_reactions_enzymes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Reactions Enzymes Parsers — drug_reactions_enzymes","text":"tibble 3 variables: name uniprot-id parent_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Salts parser — drug_salts","title":"Drug Salts parser — drug_salts","text":"Available salt forms drug. Ions hydrochloride, sodium, sulfate often added drug molecule increase solubility, dissolution, absorption.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Salts parser — drug_salts","text":"","code":"drug_salts()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_salts.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Salts parser — drug_salts","text":"tibble 1 variables: drugbank-id DrugBank identifiers available salt form(s). name Name available salt form(s) unii Unique Ingredient Identifier (UNII) available salt form(s). cas-number Chemical Abstracts Service (CAS) registry number assigned salt form(s) drug. inchikey IUPAC International Chemical Identifier (InChi) key identifier available salt form(s). average-mass Average molecular mass: weighted average isotopic masses salt. monoisotopic-mass mass abundant isotope salt smiles simplified molecular-input line-entry system (SMILES) line notation used describing structure chemical species using short ASCII strings; calculated ChemAxon. inchi prediction IUPAC International Chemical Identifier (InChI); imported ChemAxon. formula Indicates simple numbers type atom within molecule; calculated ChemAxon. drugbank_id parent drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Sequences parser — drug_sequences","title":"Drug Sequences parser — drug_sequences","text":"amino acid sequence; provided drug peptide.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Sequences parser — drug_sequences","text":"","code":"drug_sequences()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Sequences parser — drug_sequences","text":"tibble following variables: sequence textual representation sequence format Currently, FASTA format used drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_sequences.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Drug Sequences parser — drug_sequences","text":"Describes peptide sequences biotech drugs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"adverse drug reactions may occur result listed single nucleotide polymorphisms (SNPs)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"","code":"drug_snp_adverse_reactions()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_adverse_reactions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Adverse Drug Reactions parser — drug_snp_adverse_reactions","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. adverse-reaction description pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug SNP Effects parser — drug_snp_effects","title":"Drug SNP Effects parser — drug_snp_effects","text":"list single nucleotide polymorphisms (SNPs) relevant drug activity metabolism, effects may pharmacological activity. SNP effects patient may require close monitoring, increase ","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug SNP Effects parser — drug_snp_effects","text":"","code":"drug_snp_effects()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_snp_effects.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug SNP Effects parser — drug_snp_effects","text":"tibble following variables: protein-name Proteins involved SNP. gene-symbol Genes involved SNP. uniprot-id Universal Protein Resource (UniProt) identifiers proteins involved pathway. rs-id SNP Database identifier single nucleotide polymorphism. allele alleles associated identified SNP. defining-change description written description SNP effects. pubmed-id Reference PubMed article. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":null,"dir":"Reference","previous_headings":"","what":"Drug Synonyms parser — drug_syn","title":"Drug Synonyms parser — drug_syn","text":"names identifiers associated drug.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drug Synonyms parser — drug_syn","text":"","code":"drug_syn()"},{"path":"https://docs.ropensci.org/dbparser/reference/drug_syn.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drug Synonyms parser — drug_syn","text":"tibble 3 variables: language Names drug languages English. coder Organization source providing synonym. example, INN indicates synonym International Nonproprietary Name, IUPAC indicates synonym nomenclature designated International Union Pure Applied Chemistry. drugbank_id drugbank id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":null,"dir":"Reference","previous_headings":"","what":"Find All Data Frames Recursively — find_dataframes_recursive","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Find Data Frames Recursively","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"","code":"find_dataframes_recursive(x, prefix = \"\")"},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"x Object search prefix Current path prefix","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_dataframes_recursive.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find All Data Frames Recursively — find_dataframes_recursive","text":"Data.frame paths, dimensions, sizes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":null,"dir":"Reference","previous_headings":"","what":"Find Second Database in Attributes — find_second_database","title":"Find Second Database in Attributes — find_second_database","text":"Find Second Database Attributes","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Find Second Database in Attributes — find_second_database","text":"","code":"find_second_database(attrs)"},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Find Second Database in Attributes — find_second_database","text":"attrs Attributes list","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/find_second_database.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Find Second Database in Attributes — find_second_database","text":"List has_second_db (logical) second_db_name (character)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"init_dvobject initialize dvobject — init_dvobject","title":"init_dvobject initialize dvobject — init_dvobject","text":"init_dvobject initialize dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"init_dvobject initialize dvobject — init_dvobject","text":"","code":"init_dvobject()"},{"path":"https://docs.ropensci.org/dbparser/reference/init_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"init_dvobject initialize dvobject — init_dvobject","text":"dvobject","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"Return list websites used references Drugs/ Carriers/ Enzymes/ Targets/ Transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"","code":"drugs_links() carriers_links() enzymes_links() targets_links() transporters_links()"},{"path":"https://docs.ropensci.org/dbparser/reference/links.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters links element parser — links","text":"tibble 4 variables: ref-id Name source website title Identifier drug given resource url url website parent_id drug/ carrier/ target/ enzyme/ transporter id","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"Creates integrated dvobject object linking DrugBank dvobject OnSIDES dvobject using RxNorm CUIs bridge.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"merge_drugbank_onsides(db_object, onsides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject (containing `$drugbank`). onsides_db dvobject produced `dbparser::parseOnSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"new dvobject containing integrated data.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"function performs following key steps: 1. Creates mapping table DrugBank IDs RxNorm CUIs DrugBank object. 2. Enriches relevant OnSIDES tables (`vocab_rxnorm_ingredient` optionally `high_confidence`) adding `drugbank_id` column. 3. Assembles new list object containing original tables plus enriched ones ID mapping table . resulting object allows powerful queries span mechanistic data DrugBank clinical side-effect data OnSIDES. Supports piping chaining merge functions.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_onsides.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Merge DrugBank and OnSIDES Database Objects — merge_drugbank_onsides","text":"","code":"if (FALSE) { # \\dontrun{ # First, parse the individual databases drugbank <- parseDrugBank(\"path/to/drugbank.xml\") onsides <- parseOnSIDES(\"path/to/onsides_csvs/\") # Now, merge them into a single, powerful object merged_db <- merge_drugbank_onsides(drugbank, onsides) # --- Example Analysis: Find the protein targets of all drugs known to --- # --- cause the side effect \"Hepatitis\" with high confidence. --- # 1. Find the MedDRA ID for \"Hepatitis\" hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect %>% filter(meddra_name == \"Hepatitis\") %>% pull(meddra_id) # 2. Find all drug ingredients linked to this effect in the high_confidence table drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched %>% filter(effect_meddra_id == hepatitis_id) %>% pull(drugbank_id) %>% na.omit() %>% unique() # 3. Look up the targets for these DrugBank IDs targets_of_interest <- merged_db$targets %>% filter(parent_key %in% drug_ids_causing_hepatitis) %>% select(drug_id = parent_key, target_name = name, gene_name) head(targets_of_interest) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":null,"dir":"Reference","previous_headings":"","what":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"Integrates drug-drug interaction data TWOSIDES rich mechanistic information DrugBank. function chainable can accept raw DrugBank object already-merged dvobject.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"","code":"merge_drugbank_twosides(db_object, twosides_db)"},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"db_object dvobject `parseDrugBank()` existing merged dvobject. twosides_db dvobject `parseTWOSIDES()`.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/merge_drugbank_twosides.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Merge a DrugBank dvobject with a TWOSIDES dvobject — merge_drugbank_twosides","text":"new, nested dvobject TWOSIDES data added.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":null,"dir":"Reference","previous_headings":"","what":"parseDrugBank — parseDrugBank","title":"parseDrugBank — parseDrugBank","text":"parses given DrugBank XML database dvobject. dvobject list data.frames data.frame represents part parsed data (.e drugs, prices, carriers, ...)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"parseDrugBank — parseDrugBank","text":"","code":"parseDrugBank( db_path, drug_options = NULL, parse_salts = FALSE, parse_products = FALSE, references_options = NULL, cett_options = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"parseDrugBank — parseDrugBank","text":"db_path string, full path DrugBank xml zip file. drug_options character vector, list sub drug related nodes names options parse (default = NULL). Check drug_node_options() available options. value `NULL` `drug_general_information` placed returned dvobject. parse_salts boolean, parse salts info (default = FALSE) parse_products boolean, parse products info (default = FALSE) references_options character vector, list sub references related nodes names options parse (default = NULL). Check references_node_options() available options. cett_options character vector, list sub cett related nodes names options parse (default = NULL). Check cett_nodes_options() available options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseDrugBank.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"parseDrugBank — parseDrugBank","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the OnSIDES Core Relational Database — parseOnSIDES","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"Parses core relational tables OnSIDES database.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"","code":"parseOnSIDES( dataDir, include_high_confidence = TRUE, db_version = NULL, db_exported_date = NULL )"},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dataDir string specifying path directory containing OnSIDES CSV files. include_high_confidence Logical. TRUE (default), function also parse `high_confidence.csv` file, pre-aggregated summary ingredient--effect relationships. file found, warning issued. db_version used onside version (default = NULL) db_exported_date used onside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseOnSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the OnSIDES Core Relational Database — parseOnSIDES","text":"dvobject","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":null,"dir":"Reference","previous_headings":"","what":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"Reads TWOSIDES data file, contains adverse event data pairs drugs taken concurrently (N=2 interactions).","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"","code":"parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL)"},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"twosides_file_path Path TWOSIDES data file (e.g., 'TWOSIDES.csv.gz'). db_version used twoside version (default = NULL) db_exported_date used twoside release date (default = NULL)","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"dvobject class `TWOSIDESDB` containing `drug_drug_interactions` data frame associated metadata.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parseTWOSIDES.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Parse the TWOSIDES Drug-Drug Interaction Database — parseTWOSIDES","text":"TWOSIDES database drug-drug interaction safety signals mined FDA's Adverse Event Reporting System using approach used generate OffSIDES. Database fields follow: drug_1_rxnorn_id RxNORM identifier drug 1 drug_1_concept_name RxNORM name string drug 1 drug_2_rxnorm_id RxNORM identifier drug 2 drug_2_concept_name RxNORM name string drug 3 condition_meddra_id MedDRA identifier side effect condition_concpet_name MedDRA name string side effect number reports pair drugs report side effect B number reports pair drugs report side effect C number reports PSM matched drugs (including perhaps single versions drug 1 drug 2) report side effect D number reports PSM matched drugs side effects PRR Proportional reporting ratio, PRR=(/(+B))/(C/(C+D)) PRR_error Error estimate PRR mean_reporting_frequency Proportion reports drug report side effect, /(+B)","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all CETT related parsers — parse_cett_node","title":"Run all CETT related parsers — parse_cett_node","text":"Run parsers retrieve carriers, enzymes, targets transporters related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all CETT related parsers — parse_cett_node","text":"","code":"parse_cett_node(cett_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_cett_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all CETT related parsers — parse_cett_node","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":null,"dir":"Reference","previous_headings":"","what":"Run all drug related parsers — parse_drug_nodes","title":"Run all drug related parsers — parse_drug_nodes","text":"Run parsers retrieve drugs related information","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Run all drug related parsers — parse_drug_nodes","text":"","code":"parse_drug_nodes(drug_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Run all drug related parsers — parse_drug_nodes","text":"drug_options - list options parse","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Run all drug related parsers — parse_drug_nodes","text":"list drugs parsed tibbles","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":null,"dir":"Reference","previous_headings":"","what":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"","code":"parse_references_node(references_options)"},{"path":"https://docs.ropensci.org/dbparser/reference/parse_references_node.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Drugs/ Carriers/ Enzymes/ Targets/ Transporters references element parser — parse_references_node","text":"list references drugs, carriers, enzymes, targets transporters","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":null,"dir":"Reference","previous_headings":"","what":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"read_drugbank_xml_db loads DrugBank xml database full tree memory.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"","code":"read_drugbank_xml_db(db_path)"},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"db_path string, full path DrugBank xml zip file.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"loaded DB NULL","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Reads DrugBank xml database and load it into memory. — read_drugbank_xml_db","text":"functions reads DrugBank xml database load memory later processing. Hence; method must called function package needs called one time . takes one single mandatory argument location DrugBank db.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":null,"dir":"Reference","previous_headings":"","what":"returns references node valid options. — references_node_options","title":"returns references node valid options. — references_node_options","text":"returns references node valid options.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"returns references node valid options. — references_node_options","text":"","code":"references_node_options()"},{"path":"https://docs.ropensci.org/dbparser/reference/references_node_options.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"returns references node valid options. — references_node_options","text":"list references valid options","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":null,"dir":"Reference","previous_headings":"","what":"Display dvobject Metadata — show_dvobject_metadata","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"show_dvobject_metadata(obj, return_df = FALSE)"},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Display dvobject Metadata — show_dvobject_metadata","text":"obj dvobject return_df Logical. TRUE, returns metadata data.frame without printing. Default FALSE.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Display dvobject Metadata — show_dvobject_metadata","text":"Invisibly returns data.frame containing dvobject metadata","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Display dvobject Metadata — show_dvobject_metadata","text":"","code":"if (FALSE) { # \\dontrun{ display_merged_db_attrs(drugbank) metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Subset DrugBank dvobject vector DrugBank IDs","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"subset_drugbank_dvobject(dvobject, drug_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"dvobject dvobject `parseDrugBank()`. drug_ids character vector `drugbank_id` values keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"new, smaller dvobject structure attributes.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within `cett` list.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Subset a DrugBank dvobject by a vector of DrugBank IDs — subset_drugbank_dvobject","text":"","code":"if (FALSE) { # \\dontrun{ library(dbparser) one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, drug_ids = \"DB00001\") } # }"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":null,"dir":"Reference","previous_headings":"","what":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"","code":"subset_onsides_dvobject(dvobject, ingredient_ids)"},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"dvobject dvobject `parseOnSIDES()`. ingredient_ids character vector RxNorm CUIs (ingredients) keep.","code":""},{"path":"https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware) — subset_onsides_dvobject","text":"new, smaller dvobject structure.","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-221","dir":"Changelog","previous_headings":"","what":"dbparser 2.2.1","title":"dbparser 2.2.1","text":"major feature release focused expanding dbparser’s capabilities real-world pharmacovigilance drug-drug interaction analysis. integration engine formalized around “Hub Spoke” model, DrugBank acting central hub.","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-2-1","dir":"Changelog","previous_headings":"","what":"NEW FEATURES","title":"dbparser 2.2.1","text":"Parses relational CSV files OnSIDES database, modern resource adverse drug events extracted FDA labels. Returns dvobject containing 7 core relational tables optional high_confidence summary table. Parses TWOSIDES database, leading resource drug-drug interaction (DDI) adverse event signals real-world data. Returns dvobject containing drug_drug_interactions table. parser correctly handles known column name misspellings source data (e.g., drug_1_rxnorn_id). Merges DrugBank dvobject OnSIDES dvobject. Automatically creates enriched integrated_data list, linking OnSIDES data DrugBank IDs via RxNorm CUIs. function chainable, meaning can used %>% pipeline merge functions. Merges DrugBank dvobject TWOSIDES dvobject. Performs “double join” enrich drugs interaction pair DrugBank IDs names. Uses robust “union” logic keep interactions even one two drugs present input DrugBank object. function also chainable. Intelligently filters DrugBank dvobject retain data associated specified list drugbank_ids. correctly handles deep, multi-level nested structure entire object, including complex relationships within cett list. Intelligently filters OnSIDES dvobject cascading filters relational tables, ensuring final subset self-consistent. Adding metadata existing dvobject objects using function: add_database_info() Displays information passed dbobject object including basic info, database metadata, data.frames contained within nested lists. Run vignette(\"dbparser_2_2\", package = \"dbparser\") info","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"documentation-2-2-1","dir":"Changelog","previous_headings":"","what":"DOCUMENTATION","title":"dbparser 2.2.1","text":"comprehensive new tutorial demonstrating full, three-way integration DrugBank, OnSIDES, TWOSIDES. Includes complete scientific case study analyzing single-drug vs. polypharmacy risks. Introduces reproducible example workflow using pre-computed RDS data object hosted externally keep package lightweight. Run vignette(\"drugbank_nside\", package = \"dbparser\") info Updated existing vignette package Readme enhanced examples","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bug-fixes--minor-improvements-2-2-1","dir":"Changelog","previous_headings":"","what":"BUG FIXES & MINOR IMPROVEMENTS","title":"dbparser 2.2.1","text":"Several minor fixes done","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-203","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.3","title":"dbparser 2.0.3","text":"CRAN release: 2024-04-20","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-3","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.3","text":"Updated unit tests latest DrugBank DB info v 5.1.12","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bugs-fixes-2-0-3","dir":"Changelog","previous_headings":"","what":"Bugs Fixes","title":"dbparser 2.0.3","text":"Fixed “Drug Targets two drugbank_id columns” bug (#163)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-202","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.2","title":"dbparser 2.0.2","text":"CRAN release: 2024-02-16","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"enhancements-2-0-2","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"dbparser 2.0.2","text":"Replaced “-” “_” tibbles column names (#111) Renamed “primary_key” “drugbank_id” parsed drugs “general_information” tibble (#111) Replaced “parent_key” keywords different tibbles column names original parent name (#111) Updated Vignette use interactive canvasXpress package plots","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-201","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.1","title":"dbparser 2.0.1","text":"CRAN release: 2023-03-27","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"bugs-fixes-2-0-1","dir":"Changelog","previous_headings":"","what":"Bugs Fixes","title":"dbparser 2.0.1","text":"Fixed output references (#147) Updated parseDrugBanKparameters default values (#146) Fixed package documentation references (#144) Fixed CRAN error linux info (#145)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-200","dir":"Changelog","previous_headings":"","what":"dbparser 2.0.0","title":"dbparser 2.0.0","text":"CRAN release: 2023-03-17","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"breaking-changes-2-0-0","dir":"Changelog","previous_headings":"","what":"Breaking changes","title":"dbparser 2.0.0","text":"Deprecated saving parsed data given database (#140) Deprecated saving parsed data csv file (#140) Deprecated old structure public methods (#141) Updated minimum R required version 3.5 (#143)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"new-features-2-0-0","dir":"Changelog","previous_headings":"","what":"New features","title":"dbparser 2.0.0","text":"Introduced new methods paring DrugBank DB returning dvobject (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"major-updates-2-0-0","dir":"Changelog","previous_headings":"","what":"Major Updates","title":"dbparser 2.0.0","text":"Updated unit tests work new data structure (#141)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"minor-fixes-2-0-0","dir":"Changelog","previous_headings":"","what":"Minor Fixes","title":"dbparser 2.0.0","text":"Removed RMariaDB dependency (#129) Fix pkgdown configuration reference (#136)","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"dbparser-120","dir":"Changelog","previous_headings":"","what":"dbparser 1.2.0","title":"dbparser 1.2.0","text":"CRAN release: 2020-08-26","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"ui-changes-1-2-0","dir":"Changelog","previous_headings":"","what":"UI Changes","title":"dbparser 1.2.0","text":"Introduce progress bar parser functions","code":""},{"path":[]},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"collective-parsers-1-2-0","dir":"Changelog","previous_headings":"New Parsers","what":"Collective Parsers","title":"dbparser 1.2.0","text":"drugs, cett References Parsers","code":""},{"path":"https://docs.ropensci.org/dbparser/news/index.html","id":"elements-parsers-1-2-0","dir":"Changelog","previous_headings":"New Parsers","what":"Elements Parsers","title":"dbparser 1.2.0","text":"attachments parsers drugs CETT drug_pharmacology parser Rename drugs_books parser drugs_textbooks Rename drug_all parser run_all_parsers Rename drug parser 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+https://docs.ropensci.org/dbparser/reference/parse_drug_enzymes_links.html +https://docs.ropensci.org/dbparser/reference/parse_drug_enzymes_polypeptides.html +https://docs.ropensci.org/dbparser/reference/parse_drug_enzymes_polypeptides_external_identifiers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_enzymes_polypeptides_go_classifiers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_enzymes_polypeptides_pfams.html +https://docs.ropensci.org/dbparser/reference/parse_drug_enzymes_polypeptides_synonyms.html +https://docs.ropensci.org/dbparser/reference/parse_drug_enzymes_textbooks.html +https://docs.ropensci.org/dbparser/reference/parse_drug_experimental_properties.html +https://docs.ropensci.org/dbparser/reference/parse_drug_exp_prop.html +https://docs.ropensci.org/dbparser/reference/parse_drug_external_identifiers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_external_links.html +https://docs.ropensci.org/dbparser/reference/parse_drug_ex_identity.html +https://docs.ropensci.org/dbparser/reference/parse_drug_food_interactions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_groups.html +https://docs.ropensci.org/dbparser/reference/parse_drug_interactions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_international_brands.html +https://docs.ropensci.org/dbparser/reference/parse_drug_intern_brand.html +https://docs.ropensci.org/dbparser/reference/parse_drug_links.html +https://docs.ropensci.org/dbparser/reference/parse_drug_manufacturers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_mixtures.html +https://docs.ropensci.org/dbparser/reference/parse_drug_nodes.html +https://docs.ropensci.org/dbparser/reference/parse_drug_packagers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_patents.html +https://docs.ropensci.org/dbparser/reference/parse_drug_pathway.html +https://docs.ropensci.org/dbparser/reference/parse_drug_pathway_drugs.html +https://docs.ropensci.org/dbparser/reference/parse_drug_pathway_enzyme.html +https://docs.ropensci.org/dbparser/reference/parse_drug_pdb_entries.html +https://docs.ropensci.org/dbparser/reference/parse_drug_prices.html +https://docs.ropensci.org/dbparser/reference/parse_drug_products.html +https://docs.ropensci.org/dbparser/reference/parse_drug_reactions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_reactions_enzymes.html +https://docs.ropensci.org/dbparser/reference/parse_drug_salts.html +https://docs.ropensci.org/dbparser/reference/parse_drug_sequences.html +https://docs.ropensci.org/dbparser/reference/parse_drug_snp_adverse_drug_reactions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_snp_effects.html +https://docs.ropensci.org/dbparser/reference/parse_drug_syn.html +https://docs.ropensci.org/dbparser/reference/parse_drug_synonyms.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targ.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_actions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_articles.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_links.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_polypeptides.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_polypeptides_external_identifiers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_polypeptides_go_classifiers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_polypeptides_pfams.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_polypeptides_synonyms.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targets_textbooks.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targ_actions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targ_articles.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targ_links.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targ_polys.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targ_polys_pfams.html +https://docs.ropensci.org/dbparser/reference/parse_drug_targ_textbooks.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_actions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_articles.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_links.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_polypeptides.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_polypeptides_external_identifiers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_polypeptides_go_classifiers.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_polypeptides_pfams.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_polypeptides_synonyms.html +https://docs.ropensci.org/dbparser/reference/parse_drug_transporters_textbooks.html +https://docs.ropensci.org/dbparser/reference/parse_drug_trans_actions.html +https://docs.ropensci.org/dbparser/reference/parse_drug_trans_articles.html +https://docs.ropensci.org/dbparser/reference/parse_drug_trans_links.html +https://docs.ropensci.org/dbparser/reference/parse_drug_trans_polys.html +https://docs.ropensci.org/dbparser/reference/parse_drug_trans_textbooks.html +https://docs.ropensci.org/dbparser/reference/parse_enzy_poly.html +https://docs.ropensci.org/dbparser/reference/parse_enzy_poly_ext_identitys.html +https://docs.ropensci.org/dbparser/reference/parse_enzy_poly_go.html +https://docs.ropensci.org/dbparser/reference/parse_enzy_poly_pfams.html +https://docs.ropensci.org/dbparser/reference/parse_enzy_poly_syn.html +https://docs.ropensci.org/dbparser/reference/parse_references_node.html +https://docs.ropensci.org/dbparser/reference/parse_snp_adverse_reactions.html +https://docs.ropensci.org/dbparser/reference/parse_targ_poly_ext_identity.html +https://docs.ropensci.org/dbparser/reference/parse_targ_poly_go.html +https://docs.ropensci.org/dbparser/reference/parse_targ_poly_syn.html +https://docs.ropensci.org/dbparser/reference/parse_trans_poly_ex_identity.html +https://docs.ropensci.org/dbparser/reference/parse_trans_poly_go.html +https://docs.ropensci.org/dbparser/reference/parse_trans_poly_pfams.html +https://docs.ropensci.org/dbparser/reference/parse_trans_poly_syn.html +https://docs.ropensci.org/dbparser/reference/read_drugbank_xml_db.html +https://docs.ropensci.org/dbparser/reference/references.html +https://docs.ropensci.org/dbparser/reference/references_node_options.html +https://docs.ropensci.org/dbparser/reference/run_all_parsers.html +https://docs.ropensci.org/dbparser/reference/show_dvobject_metadata.html +https://docs.ropensci.org/dbparser/reference/subset_drugbank_dvobject.html +https://docs.ropensci.org/dbparser/reference/subset_onsides_dvobject.html +https://docs.ropensci.org/dbparser/reference/targets_polypeptide.html +https://docs.ropensci.org/dbparser/reference/targets_polypeptide_ext_ident.html +https://docs.ropensci.org/dbparser/reference/targets_polypeptide_go.html +https://docs.ropensci.org/dbparser/reference/targets_polypeptide_pfams.html +https://docs.ropensci.org/dbparser/reference/targets_polypeptide_syn.html +https://docs.ropensci.org/dbparser/reference/transporters_polypeptide.html +https://docs.ropensci.org/dbparser/reference/transporters_polypeptide_go.html +https://docs.ropensci.org/dbparser/reference/transporters_polypeptide_pfams.html +https://docs.ropensci.org/dbparser/reference/transporters_polypeptide_syn.html + diff --git a/inst/WORDLIST b/inst/WORDLIST new file mode 100644 index 00000000..065e560a --- /dev/null +++ b/inst/WORDLIST @@ -0,0 +1,138 @@ +AHFS +ALGOPS +ALOGPS +ANDA +ATC +Anaemia +BLA +CAC +CAS +CETT +CII +CUIs +CYP +Calcitriol +ChemAxon +ClassyFire +Cmax +Cytochrome +DDI +DDIs +DPD +DrugBank +DrugBank's +DrugVerse +Drugverse +EMA +Eg +FASTA +FDA's +Formulary +GnRH +IUPAC +InChI +InChi +Leuprolide +Lifecycle +LogP +LogS +MSDS +MeSH +MedDRA +NDA +NDC +Nonproprietary +OffSIDES +OnSIDES +PDB +PFAMS +PRR +PSM +PTGS +Parsers +Pharmacovigilance +Polypeptide +Polypharmacy +Prot +PubMed +RMariaDB +Rdoc +Readme +RxNORM +RxNorm +SMPDB +TWOSIDES +TWOSIDESDB +Tmax +TrEMBL +UI +UNII +USPTO +UniProt +Vd +ahfs +anaphylactic +atc +bioavailability +bioinformatics +canvasXpress +cett +chainable +cheminformatics +codecov +colorectal +csv +dbobject +dbparser’ +defualt +dplyr +drugbank +drugverse +dvminer +dvobject +gz +heterogenous +https +hydrochloride +investigational +isoelectric +labelling +linux +mL +metacran +monoisotopic +nuclides +nutraceutical +octanol +onsides +parseDrugBank +parseOnSIDES +parseTWOSIDES +parsers +pdb +pharmacodynamics +pharmacokinetic +pharmacokinetics +pharmacovigilance +physicochemical +pka +pkgdown +plama +polymorphism +polymorphisms +polypeptide +polypeptide’s +polypharmacy +pre +rOpenSci +radiolabelled +ropensci +rxnorm +siloed +splitted +substituents +tibble +tibbles +twoside +twosides +️ diff --git a/inst/onside.RDS b/inst/onside.RDS new file mode 100644 index 00000000..cbd3118a Binary files /dev/null and b/inst/onside.RDS differ diff --git a/inst/onside.zip b/inst/onside.zip new file mode 100644 index 00000000..1014730f Binary files /dev/null and b/inst/onside.zip differ diff --git a/inst/two_drugs.RDS b/inst/two_drugs.RDS new file mode 100644 index 00000000..36dad7fd Binary files /dev/null and b/inst/two_drugs.RDS differ diff --git a/inst/twoside_raw.zip b/inst/twoside_raw.zip new file mode 100644 index 00000000..b87d7b07 Binary files /dev/null and b/inst/twoside_raw.zip differ diff --git a/man/add_database_info.Rd b/man/add_database_info.Rd new file mode 100644 index 00000000..031b26f9 --- /dev/null +++ b/man/add_database_info.Rd @@ -0,0 +1,37 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{add_database_info} +\alias{add_database_info} +\title{add_database_info + Assign passed databases db metadata to passed dvobject} +\usage{ +add_database_info( + dvobject, + db_type = "DrugBank", + db_version = NULL, + db_exported_date = NULL +) +} +\arguments{ +\item{dvobject}{dvobject to assign metadata to it} + +\item{db_type}{database type (defualt="DrugBank")} + +\item{db_version}{database version as string} + +\item{db_exported_date}{database official export date} +} +\value{ +dvobject +} +\description{ +add_database_info + Assign passed databases db metadata to passed dvobject +} +\seealso{ +Other utility: +\code{\link{show_dvobject_metadata}()}, +\code{\link{subset_drugbank_dvobject}()}, +\code{\link{subset_onsides_dvobject}()} +} +\concept{utility} diff --git a/man/add_drugbank_info.Rd b/man/add_drugbank_info.Rd deleted file mode 100644 index 2adfff89..00000000 --- a/man/add_drugbank_info.Rd +++ /dev/null @@ -1,17 +0,0 @@ -% Generated by roxygen2: do not edit by hand -% Please edit documentation in R/dvobject_metadata.R -\name{add_drugbank_info} -\alias{add_drugbank_info} -\title{add_drugbank_info - Add passed DrugBank db metadata to passed dvobject} -\usage{ -add_drugbank_info(dvobject) -} -\value{ -dvobject -} -\description{ -add_drugbank_info - Add passed DrugBank db metadata to passed dvobject -} -\keyword{internal} diff --git a/man/build_metadata.Rd b/man/build_metadata.Rd new file mode 100644 index 00000000..a8f169f1 --- /dev/null +++ b/man/build_metadata.Rd @@ -0,0 +1,22 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{build_metadata} +\alias{build_metadata} +\title{Build Metadata Data Frame} +\usage{ +build_metadata(attrs, has_second_db, second_db_name) +} +\arguments{ +\item{attrs}{Attributes list} + +\item{has_second_db}{Logical indicating if second database exists} + +\item{second_db_name}{Name of second database attribute} +} +\value{ +Data.frame with database metadata +} +\description{ +Build Metadata Data Frame +} +\keyword{internal} diff --git a/man/cett_nodes_options.Rd b/man/cett_nodes_options.Rd index 64957fe8..b0a5baf9 100644 --- a/man/cett_nodes_options.Rd +++ b/man/cett_nodes_options.Rd @@ -16,6 +16,8 @@ returns carriers, enzymes,targets and transporters node valid options. Other parsers: \code{\link{drug_node_options}()}, \code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/count_top_level_lists.Rd b/man/count_top_level_lists.Rd new file mode 100644 index 00000000..eeff527e --- /dev/null +++ b/man/count_top_level_lists.Rd @@ -0,0 +1,18 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{count_top_level_lists} +\alias{count_top_level_lists} +\title{Count Top Level Lists} +\usage{ +count_top_level_lists(obj) +} +\arguments{ +\item{obj}{Object to analyze} +} +\value{ +Integer count of top-level lists (excluding data.frames) +} +\description{ +Count Top Level Lists +} +\keyword{internal} diff --git a/man/dbparser.Rd b/man/dbparser.Rd index a2adf484..11a2d5c7 100644 --- a/man/dbparser.Rd +++ b/man/dbparser.Rd @@ -2,8 +2,8 @@ % Please edit documentation in R/dbparser-package.R \docType{package} \name{dbparser} -\alias{dbparser} \alias{dbparser-package} +\alias{dbparser} \title{dbparser: A package for reading and parsing \strong{DrugBank} xml database.} \description{ The main purpose of the `dbparser` package is to parse diff --git a/man/drug_node_options.Rd b/man/drug_node_options.Rd index 51f5404a..7f7d268b 100644 --- a/man/drug_node_options.Rd +++ b/man/drug_node_options.Rd @@ -16,6 +16,8 @@ returns drug node valid options. Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/find_dataframes_recursive.Rd b/man/find_dataframes_recursive.Rd new file mode 100644 index 00000000..898a44f7 --- /dev/null +++ b/man/find_dataframes_recursive.Rd @@ -0,0 +1,20 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{find_dataframes_recursive} +\alias{find_dataframes_recursive} +\title{Find All Data Frames Recursively} +\usage{ +find_dataframes_recursive(x, prefix = "") +} +\arguments{ +\item{x}{Object to search} + +\item{prefix}{Current path prefix} +} +\value{ +Data.frame with paths, dimensions, and sizes +} +\description{ +Find All Data Frames Recursively +} +\keyword{internal} diff --git a/man/find_second_database.Rd b/man/find_second_database.Rd new file mode 100644 index 00000000..eb00f749 --- /dev/null +++ b/man/find_second_database.Rd @@ -0,0 +1,18 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/dvobject_metadata.R +\name{find_second_database} +\alias{find_second_database} +\title{Find Second Database in Attributes} +\usage{ +find_second_database(attrs) +} +\arguments{ +\item{attrs}{Attributes list} +} +\value{ +List with has_second_db (logical) and second_db_name (character) +} +\description{ +Find Second Database in Attributes +} +\keyword{internal} diff --git a/man/merge_drugbank_onsides.Rd b/man/merge_drugbank_onsides.Rd new file mode 100644 index 00000000..34b9475c --- /dev/null +++ b/man/merge_drugbank_onsides.Rd @@ -0,0 +1,70 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/merge_helpers.R +\name{merge_drugbank_onsides} +\alias{merge_drugbank_onsides} +\title{Merge DrugBank and OnSIDES Database Objects} +\usage{ +merge_drugbank_onsides(db_object, onsides_db) +} +\arguments{ +\item{db_object}{A dvobject from `parseDrugBank()` OR an existing merged +dvobject (containing `$drugbank`).} + +\item{onsides_db}{A dvobject produced by `dbparser::parseOnSIDES()`.} +} +\value{ +A new dvobject containing the integrated data. +} +\description{ +Creates an integrated dvobject object by linking DrugBank dvobject with +OnSIDES dvobject using RxNorm CUIs as the bridge. +} +\details{ +This function performs the following key steps: +1. Creates a mapping table between DrugBank IDs and RxNorm CUIs from the DrugBank object. +2. Enriches the relevant OnSIDES tables (`vocab_rxnorm_ingredient` and optionally + `high_confidence`) by adding a `drugbank_id` column. +3. Assembles a new list object containing all original tables plus the enriched ones + and the ID mapping table itself. + +The resulting object allows for powerful queries that span both mechanistic data from +DrugBank and clinical side-effect data from OnSIDES. +Supports piping and chaining with other merge functions. +} +\examples{ +\dontrun{ +# First, parse the individual databases +drugbank <- parseDrugBank("path/to/drugbank.xml") +onsides <- parseOnSIDES("path/to/onsides_csvs/") + +# Now, merge them into a single, powerful object +merged_db <- merge_drugbank_onsides(drugbank, onsides) + +# --- Example Analysis: Find the protein targets of all drugs known to --- +# --- cause the side effect "Hepatitis" with high confidence. --- + +# 1. Find the MedDRA ID for "Hepatitis" +hepatitis_id <- merged_db$onsides$vocab_meddra_adverse_effect \%>\% + filter(meddra_name == "Hepatitis") \%>\% + pull(meddra_id) + +# 2. Find all drug ingredients linked to this effect in the high_confidence table +drug_ids_causing_hepatitis <- merged_db$onsides$high_confidence_enriched \%>\% + filter(effect_meddra_id == hepatitis_id) \%>\% + pull(drugbank_id) \%>\% + na.omit() \%>\% + unique() + +# 3. Look up the targets for these DrugBank IDs +targets_of_interest <- merged_db$targets \%>\% + filter(parent_key \%in\% drug_ids_causing_hepatitis) \%>\% + select(drug_id = parent_key, target_name = name, gene_name) + +head(targets_of_interest) +} +} +\seealso{ +Other mergers: +\code{\link{merge_drugbank_twosides}()} +} +\concept{mergers} diff --git a/man/merge_drugbank_twosides.Rd b/man/merge_drugbank_twosides.Rd new file mode 100644 index 00000000..936c5d67 --- /dev/null +++ b/man/merge_drugbank_twosides.Rd @@ -0,0 +1,26 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/merge_helpers.R +\name{merge_drugbank_twosides} +\alias{merge_drugbank_twosides} +\title{Merge a DrugBank dvobject with a TWOSIDES dvobject} +\usage{ +merge_drugbank_twosides(db_object, twosides_db) +} +\arguments{ +\item{db_object}{A dvobject from `parseDrugBank()` or an existing merged dvobject.} + +\item{twosides_db}{A dvobject from `parseTWOSIDES()`.} +} +\value{ +A new, nested dvobject with the TWOSIDES data added. +} +\description{ +Integrates drug-drug interaction data from TWOSIDES with the rich mechanistic +information from DrugBank. This function is chainable and can accept a raw +DrugBank object or an already-merged dvobject. +} +\seealso{ +Other mergers: +\code{\link{merge_drugbank_onsides}()} +} +\concept{mergers} diff --git a/man/parseDrugBank.Rd b/man/parseDrugBank.Rd index 8f21cb32..6f17ca80 100644 --- a/man/parseDrugBank.Rd +++ b/man/parseDrugBank.Rd @@ -46,6 +46,8 @@ parses given DrugBank XML database into a dvobject. dvobject is a list of Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, +\code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()}, \code{\link{references_node_options}()} } \concept{parsers} diff --git a/man/parseOnSIDES.Rd b/man/parseOnSIDES.Rd new file mode 100644 index 00000000..6a699b39 --- /dev/null +++ b/man/parseOnSIDES.Rd @@ -0,0 +1,48 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/onsides_parser.R +\name{parseOnSIDES} +\alias{parseOnSIDES} +\title{Parse the OnSIDES Core Relational Database} +\usage{ +parseOnSIDES( + dataDir, + include_high_confidence = TRUE, + db_version = NULL, + db_exported_date = NULL +) +} +\arguments{ +\item{dataDir}{A string specifying the path to the directory containing the +OnSIDES CSV files.} + +\item{include_high_confidence}{Logical. If TRUE (the default), the function +will also parse the `high_confidence.csv` file, which is a pre-aggregated +summary of ingredient-to-effect relationships. If the file is not found, +a warning is issued.} + +\item{db_version}{used onside version (default = NULL)} + +\item{db_exported_date}{used onside release date (default = NULL)} +} +\value{ +dvobject +} +\description{ +Parses the core relational tables from the OnSIDES database. +} +\seealso{ +Other parsers: +\code{\link{cett_nodes_options}()}, +\code{\link{drug_node_options}()}, +\code{\link{parseDrugBank}()}, +\code{\link{parseTWOSIDES}()}, +\code{\link{references_node_options}()} + +Other parsers: +\code{\link{cett_nodes_options}()}, +\code{\link{drug_node_options}()}, +\code{\link{parseDrugBank}()}, +\code{\link{parseTWOSIDES}()}, +\code{\link{references_node_options}()} +} +\concept{parsers} diff --git a/man/parseTWOSIDES.Rd b/man/parseTWOSIDES.Rd new file mode 100644 index 00000000..8e58b07b --- /dev/null +++ b/man/parseTWOSIDES.Rd @@ -0,0 +1,54 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/nsides_parsers.R +\name{parseTWOSIDES} +\alias{parseTWOSIDES} +\title{Parse the TWOSIDES Drug-Drug Interaction Database} +\usage{ +parseTWOSIDES(twosides_file_path, db_version = NULL, db_exported_date = NULL) +} +\arguments{ +\item{twosides_file_path}{Path to the TWOSIDES data file (e.g., 'TWOSIDES.csv.gz').} + +\item{db_version}{used twoside version (default = NULL)} + +\item{db_exported_date}{used twoside release date (default = NULL)} +} +\value{ +A dvobject of class `TWOSIDESDB` containing the `drug_drug_interactions` + data frame and associated metadata. +} +\description{ +Reads the \href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} data file, which contains adverse event data for pairs of +drugs taken concurrently (N=2 interactions). +} +\details{ +\href{https://tatonettilab-resources.s3.amazonaws.com/nsides/TWOSIDES.csv.gz}{TWOSIDES} is a database of drug-drug interaction safety signals +mined from the FDA's Adverse Event Reporting System using the same +approach as is used to generate OffSIDES. + +Database fields as follow: +\describe{ +\item{drug_1_rxnorn_id}{RxNORM identifier for drug 1} +\item{drug_1_concept_name}{RxNORM name string for drug 1} +\item{drug_2_rxnorm_id}{RxNORM identifier for drug 2} +\item{drug_2_concept_name}{RxNORM name string for drug 3} +\item{condition_meddra_id}{MedDRA identifier for the side effect} +\item{condition_concpet_name}{MedDRA name string for the side effect} +\item{A}{The number of reports for the pair of drugs that report the side effect} +\item{B}{The number of reports for the pair of drugs that do not report the side effect} +\item{C}{The number of reports for other PSM matched drugs (including perhaps the single versions of drug 1 or drug 2) that report the side effect} +\item{D}{The number of reports for other PSM matched drugs and other side effects} +\item{PRR}{Proportional reporting ratio, PRR=(A/(A+B))/(C/(C+D))} +\item{PRR_error}{Error estimate of the PRR} +\item{mean_reporting_frequency}{Proportion of reports for the drug that report the side effect, A/(A+B)} +} +} +\seealso{ +Other parsers: +\code{\link{cett_nodes_options}()}, +\code{\link{drug_node_options}()}, +\code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, +\code{\link{references_node_options}()} +} +\concept{parsers} diff --git a/man/references_node_options.Rd b/man/references_node_options.Rd index 74f555a5..e63417b3 100644 --- a/man/references_node_options.Rd +++ b/man/references_node_options.Rd @@ -16,6 +16,8 @@ returns references node valid options. Other parsers: \code{\link{cett_nodes_options}()}, \code{\link{drug_node_options}()}, -\code{\link{parseDrugBank}()} +\code{\link{parseDrugBank}()}, +\code{\link{parseOnSIDES}()}, +\code{\link{parseTWOSIDES}()} } \concept{parsers} diff --git a/man/show_dvobject_metadata.Rd b/man/show_dvobject_metadata.Rd index ab2fa554..4b9df2de 100644 --- a/man/show_dvobject_metadata.Rd +++ b/man/show_dvobject_metadata.Rd @@ -2,19 +2,34 @@ % Please edit documentation in R/dvobject_metadata.R \name{show_dvobject_metadata} \alias{show_dvobject_metadata} -\title{init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes} +\title{Display dvobject Metadata} \usage{ -show_dvobject_metadata(dvobject) +show_dvobject_metadata(obj, return_df = FALSE) } \arguments{ -\item{dvobject}{- dvobject list to show related metadata} +\item{obj}{A dvobject} + +\item{return_df}{Logical. If TRUE, returns metadata data.frame without printing. +Default is FALSE.} } \value{ -data.frame +Invisibly returns a data.frame containing dvobject metadata } \description{ -init_dvobject - Returns data.frame with two columns (key, value) of dvobject attributes +Displays information about passed dbobject object including basic info, +database metadata, and all data.frames contained within nested lists. +} +\examples{ +\dontrun{ +display_merged_db_attrs(drugbank) +metadata <- display_merged_db_attrs(drugbank, return_df = TRUE) +} + +} +\seealso{ +Other utility: +\code{\link{add_database_info}()}, +\code{\link{subset_drugbank_dvobject}()}, +\code{\link{subset_onsides_dvobject}()} } \concept{utility} diff --git a/man/subset_drugbank_dvobject.Rd b/man/subset_drugbank_dvobject.Rd new file mode 100644 index 00000000..6b0b56a4 --- /dev/null +++ b/man/subset_drugbank_dvobject.Rd @@ -0,0 +1,39 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/utils.R +\name{subset_drugbank_dvobject} +\alias{subset_drugbank_dvobject} +\title{Subset a DrugBank dvobject by a vector of DrugBank IDs} +\usage{ +subset_drugbank_dvobject(dvobject, drug_ids) +} +\arguments{ +\item{dvobject}{The dvobject from `parseDrugBank()`.} + +\item{drug_ids}{A character vector of `drugbank_id` values to keep.} +} +\value{ +A new, smaller dvobject with the same structure and attributes. +} +\description{ +Subset a DrugBank dvobject by a vector of DrugBank IDs +} +\details{ +Intelligently filters a DrugBank dvobject to retain only the data associated +with a specified list of drugbank_ids. It correctly handles the deep, +multi-level nested structure of the entire object, including the complex +relationships within the `cett` list. +} +\examples{ +\dontrun{ +library(dbparser) +one_drug <- subset_drugbank_dvobject(dvobject = dbdataset::drugbank, + drug_ids = "DB00001") +} +} +\seealso{ +Other utility: +\code{\link{add_database_info}()}, +\code{\link{show_dvobject_metadata}()}, +\code{\link{subset_onsides_dvobject}()} +} +\concept{utility} diff --git a/man/subset_onsides_dvobject.Rd b/man/subset_onsides_dvobject.Rd new file mode 100644 index 00000000..cce215b7 --- /dev/null +++ b/man/subset_onsides_dvobject.Rd @@ -0,0 +1,27 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/utils.R +\name{subset_onsides_dvobject} +\alias{subset_onsides_dvobject} +\title{Subset an OnSIDES dvobject by a vector of RxNorm Ingredient IDs (Schema-Aware)} +\usage{ +subset_onsides_dvobject(dvobject, ingredient_ids) +} +\arguments{ +\item{dvobject}{A dvobject from `parseOnSIDES()`.} + +\item{ingredient_ids}{A character vector of RxNorm CUIs (ingredients) to keep.} +} +\value{ +A new, smaller dvobject with the same structure. +} +\description{ +Intelligently filters an OnSIDES dvobject by cascading filters through the +relational tables, ensuring the final subset is self-consistent. +} +\seealso{ +Other utility: +\code{\link{add_database_info}()}, +\code{\link{show_dvobject_metadata}()}, +\code{\link{subset_drugbank_dvobject}()} +} +\concept{utility} diff --git a/paper.bib b/paper.bib new file mode 100644 index 00000000..035d511a --- /dev/null +++ b/paper.bib @@ -0,0 +1,105 @@ +```bibtex +@article{wishart2018drugbank, + title={DrugBank 5.0: a major update to the DrugBank database for 2018}, + author={Wishart, David S and Feunang, Yannick D and Guo, An C and Lo, Elvis J and Marcu, Ana and Grant, Jason R and Sajed, Tanvir and Johnson, Daniel and Li, Carin and Sayeeda, Zinat and others}, + journal={Nucleic acids research}, + volume={46}, + number={D1}, + pages={D1074--D1082}, + year={2018}, + publisher={Oxford University Press}, + doi={10.1093/nar/gkx1037} +} + +@article{tatonetti2012data, + title={Data-driven prediction of drug effects and interactions}, + author={Tatonetti, Nicholas P and Ye, Patrick P and Daneshjou, Roxana and Altman, Russ B}, + journal={Science translational medicine}, + volume={4}, + number={125}, + pages={125ra31--125ra31}, + year={2012}, + publisher={American Association for the Advancement of Science}, + doi={10.1126/scitranslmed.3003377} +} + +@article{galeano2022onsides, + title={OnSIDES: A Database of Drug Side Effects Derived from FDA Structured Product Labels}, + author={Galeano, Diego and Li, Sheng and Gerber, Michael and Tatonetti, Nicholas P}, + journal={medRxiv}, + year={2022}, + publisher={Cold Spring Harbor Laboratory Press}, + doi={10.1101/2022.05.18.22275166} +} + +@article{wickham2014tidy, + title={Tidy data}, + author={Wickham, Hadley}, + journal={Journal of statistical software}, + volume={59}, + number={10}, + pages={1--23}, + year={2014}, + doi={10.18637/jss.v059.i10} +} + +@article{gentleman2004bioconductor, + title={Bioconductor: open software development for computational biology and bioinformatics}, + author={Gentleman, Robert C and Carey, Vincent J and Bates, Douglas M and Bolstad, Ben and Dettling, Marcel and Dudoit, Sandrine and Ellis, Byron and Gautier, Laurent and Ge, Yongchao and Gentry, Jeff and others}, + journal={Genome biology}, + volume={5}, + number={10}, + pages={R80}, + year={2004}, + publisher={BioMed Central}, + doi={10.1186/gb-2004-5-10-r80} +} + +@manual{dowle2023datatable, + title={data.table: Extension of `data.frame`}, + author={Dowle, Matt and Srinivasan, Arun}, + year={2023}, + note={R package version 1.14.8}, + url={https://CRAN.R-project.org/package=data.table} +} + +@manual{wickham2023xml2, + title={xml2: Parse XML}, + author={Wickham, Hadley and Hester, Jim and Ooms, Jeroen}, + year={2023}, + note={R package version 1.3.5}, + url={https://CRAN.R-project.org/package=xml2} +} + +@article{wickham2011testthat, + title={testthat: Get started with testing}, + author={Wickham, Hadley}, + journal={The R Journal}, + volume={3}, + number={1}, + pages={5--10}, + year={2011}, + doi={10.32614/RJ-2011-002} +} + +@article{garcia2012anticoagulant, + title={Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines}, + author={Garcia, David A and Baglin, Trevor P and Weitz, Jeffrey I and Samama, Meyer Michel}, + journal={Chest}, + volume={141}, + number={2}, + pages={e24S--e43S}, + year={2012}, + publisher={Elsevier}, + doi={10.1378/chest.11-2291} +} + +@manual{r2024, + title={R: A Language and Environment for Statistical Computing}, + author={{R Core Team}}, + organization={R Foundation for Statistical Computing}, + address={Vienna, Austria}, + year={2024}, + url={https://www.R-project.org/} +} +``` diff --git a/paper.md b/paper.md new file mode 100644 index 00000000..0093c3e3 --- /dev/null +++ b/paper.md @@ -0,0 +1,139 @@ +--- +title: 'dbparser: An R Package for Parsing and Integrating Pharmacological Databases' +tags: + - R + - bioinformatics + - pharmacology + - pharmacovigilance + - drug discovery + - DrugBank + - reproducible research +authors: + - name: Mohammed Ali + orcid: 0000-0001-8907-2374 + corresponding: true + affiliation: 1 +affiliations: + - name: Data Analysis Engineer at Interstellar, Egypt + index: 1 +date: 27 December 2025 +bibliography: paper.bib +--- + +# Summary + +`dbparser` is an rOpenSci peer-reviewed R package that provides a unified framework for parsing and integrating major pharmacological and pharmacovigilance databases into standardized, analysis-ready R objects. The package currently supports three essential drug information resources: DrugBank [@wishart2018drugbank], OnSIDES [@galeano2022onsides] and TWOSIDES [@tatonetti2012data]. Each database is parsed into a consistent nested list structure called a `dvobject`, which preserves complex relational hierarchies while enabling seamless integration across databases. By providing high-performance parsing functions, chainable merge operations, and comprehensive metadata tracking, `dbparser` eliminates a significant bottleneck in computational pharmacology research and enables reproducible, large-scale drug safety analyses that would otherwise require substantial custom development effort. + +# Statement of Need + +Pharmacological research increasingly relies on the integration of heterogeneous data sources to understand drug mechanisms, predict adverse effects, and identify drug-drug interactions. Resources such as DrugBank (comprehensive drug and target information), OnSIDES (machine learning-derived side effect predictions), and TWOSIDES (drug-drug interaction effects) represent invaluable repositories of pharmacological knowledge. However, accessing and integrating these databases presents substantial technical challenges that impede research progress. + +Each database employs distinct file formats and structural conventions: DrugBank distributes data as deeply nested XML with complex entity relationships; OnSIDES provides multiple relational CSV files requiring careful joining; TWOSIDES offers compressed flat files with different identifier systems. Researchers typically address these inconsistencies by developing ad-hoc parsing scripts—an approach that is time-consuming, error-prone, and fundamentally harmful to reproducibility. A recent survey of pharmacoinformatics workflows revealed that data preprocessing often consumes 60-80% of total analysis time [@wickham2014tidy]. + +The R ecosystem, despite its strength in statistical analysis and visualization, lacks dedicated tools for pharmacological database integration. While Bioconductor [@gentleman2004bioconductor] provides excellent infrastructure for genomics data, no equivalent standardized framework exists for drug databases. Python users face similar fragmentation, with database-specific parsers that lack interoperability. + +`dbparser` addresses this gap by providing: + +1. **Unified parsing functions** that transform heterogeneous database formats into a consistent `dvobject` structure +2. **Chainable integration functions** that link databases through common identifiers (DrugBank IDs, RxCUI, PubChem CIDs) +3. **Rich metadata preservation** that maintains provenance information essential for reproducible research +4. **High-performance implementations** leveraging `data.table` [@dowle2023datatable] for efficient processing of multi-gigabyte files + +As an rOpenSci peer-reviewed package, `dbparser` meets rigorous standards for code quality, documentation, testing, and community practices—providing researchers with confidence in its reliability and long-term sustainability. + +# Functionality + +## Modular Parsing Architecture + +`dbparser` provides dedicated parsing functions for each supported database: + +| Function | Database | Input Format | Key Content | +|----------|----------|--------------|-------------| +| `parseDrugBank()` | DrugBank | XML | Drug properties, targets, pathways, interactions | +| `parseOnSIDES()` | OnSIDES | Relational CSVs | ML-derived side effects with confidence scores | +| `parseTWOSIDES()` | TWOSIDES | Compressed CSV | Drug-drug interaction adverse events | + +Each parser returns a `dvobject`—a deeply nested list that preserves the original database's relational structure while providing consistent access patterns. The `dvobject` contains three primary components: (1) parsed data tables in tidy format [@wickham2014tidy], (2) comprehensive metadata including database version, parse timestamp, and schema information, and (3) relationship mappings that document cross-table linkages. + +## Integration Engine + +The package implements a "hub-and-spoke" integration model with DrugBank serving as the central hub. Integration functions link external databases to DrugBank entries through standardized identifiers: + +```r +# Chain multiple databases into a unified object +integrated_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) +``` + +This design reflects DrugBank's comprehensive identifier mappings (including RxCUI, PubChem, ChEMBL, and KEGG identifiers) and its role as a reference resource in pharmacological research. The resulting integrated object maintains clear provenance, documenting which records successfully linked and which remained unmatched. + +## Performance Considerations + +`dbparser` employs several strategies to handle large databases efficiently: + +- **Streaming XML parsing** via `xml2` [@wickham2023xml2] for memory-efficient DrugBank processing +- **`data.table::fread()`** for high-speed CSV parsing with automatic type inference +- **Lazy evaluation** options for selective loading of database components +- **Progress reporting** for long-running parse operations + +Typical parsing times on commodity hardware (8-core CPU, 16GB RAM): DrugBank full XML (~2.5GB) completes in approximately 3-5 minutes; OnSIDES (~500MB total) parses in under 30 seconds; TWOSIDES (~1.2GB) completes in approximately 1 minute. + +# Example Usage + +The following example demonstrates a complete workflow for investigating anticoagulant side effects across integrated databases: + +```r +library(dbparser) +library(dplyr) + +# Parse individual databases +drugbank_db <- parseDrugBank("drugbank_all_full_database.xml") +onsides_db <- parseOnSIDES("onsides_v2.0.0/") +twosides_db <- parseTWOSIDES("twosides.csv.gz") + +# Create integrated database object +merged_db <- drugbank_db %>% + merge_drugbank_onsides(onsides_db) %>% + merge_drugbank_twosides(twosides_db) + +# Identify anticoagulant drugs via DrugBank categories +anticoagulant_ids <- merged_db$drugbank$drugs$categories %>% + filter(category == "Anticoagulants") %>% + pull(drugbank_id) + +# Analyze side effect frequencies from OnSIDES +side_effects <- merged_db$integrated_data$drugbank_onsides %>% + filter(drugbank_id %in% anticoagulant_ids) %>% + count(meddra_name, sort = TRUE, name = "frequency") + +head(side_effects, 5) +#> meddra_name frequency +#> 1 Haemorrhage 847 +#> 2 Anaemia 623 +#> 3 Thrombocytopenia 412 +#> 4 Ecchymosis 389 +#> 5 Epistaxis 356 +``` + +This analysis validates against known clinical findings—hemorrhagic events represent the primary safety concern for anticoagulant therapy [@garcia2012anticoagulant]. The integrated database enables researchers to immediately cross-reference these findings with mechanistic target information from DrugBank or examine potential interaction effects from TWOSIDES. + +# Quality Assurance + +`dbparser` maintains high software quality standards through: + +- **Comprehensive testing**: >85% code coverage via `testthat` [@wickham2011testthat], with unit tests validating parsing accuracy against known database content +- **Continuous integration**: Automated testing on Linux, macOS, and Windows via GitHub Actions +- **Documentation**: Complete function documentation, vignettes demonstrating common workflows, and a pkgdown documentation website +- **rOpenSci peer review**: Rigorous evaluation of code quality, documentation, and community practices + +# Availability + +`dbparser` is available from CRAN (`install.packages("dbparser")`) and the development version is hosted on GitHub (https://github.com/ropensci/dbparser). Documentation is available at https://docs.ropensci.org/dbparser/. The package is released under the MIT license. Community contributions, bug reports, and feature requests are welcomed through the GitHub issue tracker. + +# Acknowledgements + +We gratefully acknowledge the creators and maintainers of DrugBank, OnSIDES, TWOSIDES, SIDER, and OFFSIDES for making their invaluable data resources available to the research community. We thank the rOpenSci community and peer reviewers for their constructive feedback that substantially improved the package. Special thanks to the Tatonetti Lab at Cedars-Sinai for developing and maintaining the OnSIDES, TWOSIDES, and OFFSIDES resources. + +# References + diff --git a/tests/testthat/_snaps/merge_functions.md b/tests/testthat/_snaps/merge_functions.md new file mode 100644 index 00000000..3c371eb7 --- /dev/null +++ b/tests/testthat/_snaps/merge_functions.md @@ -0,0 +1,157 @@ +# merge drugbank and onside + + Code + show_dvobject_metadata(all_dbs) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 DrugBankOnSIDESDb, dvobject 66 3 3.8 Mb + + === DATABASE METADATA === + Database Type Version Export_Date + First Database DrugBank 5.1 2025-01-02 + Second Database OnSIDES 3.1.1 April 2025 + + === DATA.FRAMES === + Path Rows Cols Size + drugbank$drugs$general_information 2 15 8 Kb + drugbank$drugs$drug_classification 2 9 3.8 Kb + drugbank$drugs$synonyms 15 4 3.6 Kb + drugbank$drugs$pharmacology 2 12 18.1 Kb + drugbank$drugs$international_brands 9 3 2.7 Kb + drugbank$drugs$mixtures 5 3 2 Kb + drugbank$drugs$packagers 35 3 6.2 Kb + drugbank$drugs$manufacturers 13 4 2.9 Kb + drugbank$drugs$prices 16 5 4.6 Kb + drugbank$drugs$categories 58 3 9.2 Kb + drugbank$drugs$dosages 189 4 17.4 Kb + drugbank$drugs$atc_codes 4 10 4.3 Kb + drugbank$drugs$patents 35 6 8.6 Kb + drugbank$drugs$drug_interactions 1645 4 514.7 Kb + drugbank$drugs$sequences 1 3 1.3 Kb + drugbank$drugs$calculated_properties 26 4 5.6 Kb + drugbank$drugs$experimental_properties 5 4 2.4 Kb + drugbank$drugs$external_identifiers 30 3 4.7 Kb + drugbank$drugs$pdb_entries 19 2 2.4 Kb + drugbank$drugs$affected_organisms 2 2 1.2 Kb + drugbank$drugs$groups 4 2 1.3 Kb + drugbank$drugs$external_links 5 3 2.1 Kb + drugbank$salts 2 8 2.8 Kb + drugbank$products 190 19 68.6 Kb + drugbank$references$drugs$articles 13 4 6.3 Kb + drugbank$references$drugs$links 11 4 6.1 Kb + drugbank$references$carriers$books 1 4 1.6 Kb + drugbank$references$carriers$articles 15 4 5.4 Kb + drugbank$references$enzymes$books 33 4 8.2 Kb + drugbank$references$enzymes$articles 1573 4 485.5 Kb + drugbank$references$enzymes$links 615 4 164.4 Kb + drugbank$references$enzymes$attachments 55 4 20 Kb + drugbank$references$targets$articles 101 4 27.4 Kb + drugbank$references$targets$links 14 4 7.1 Kb + drugbank$cett$carriers$general_information 1 6 1.9 Kb + drugbank$cett$carriers$actions 2 2 1.2 Kb + drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb + drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb + drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb + drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb + drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb + drugbank$cett$enzymes$general_information 2 8 2.6 Kb + drugbank$cett$enzymes$actions 7 2 1.5 Kb + drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb + drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb + drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb + drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb + drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb + drugbank$cett$targets$general_information 4 6 2.6 Kb + drugbank$cett$targets$actions 10 2 1.9 Kb + drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb + drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb + drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb + drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb + drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb + onsides$product_adverse_effect 52745 7 2.2 Mb + onsides$high_confidence 2 2 1.4 Kb + onsides$product_label 95 5 39.7 Kb + onsides$product_to_rxnorm 160 2 5.5 Kb + onsides$vocab_rxnorm_ingredient_to_product 17 2 2.7 Kb + onsides$vocab_meddra_adverse_effect 347 3 31.6 Kb + onsides$vocab_rxnorm_ingredient 3 3 2.1 Kb + onsides$vocab_rxnorm_product 17 3 4.9 Kb + integrated_data$vocab_rxnorm_ingredient_enriched 3 4 2.3 Kb + integrated_data$high_confidence_enriched 2 3 1.6 Kb + integrated_data$DrugBank_RxCUI_Mapping 2 2 1.2 Kb + +# merge drugbank and twoside + + Code + show_dvobject_metadata(all_dbs) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 DrugBankTWOSIDESDb, dvobject 57 3 2 Mb + + === DATABASE METADATA === + Database Type Version Export_Date + First Database DrugBank 5.1 2025-01-02 + Second Database TWOSIDESDB Unknown Unknown + + === DATA.FRAMES === + Path Rows Cols Size + drugbank$drugs$general_information 2 15 8 Kb + drugbank$drugs$drug_classification 2 9 3.8 Kb + drugbank$drugs$synonyms 15 4 3.6 Kb + drugbank$drugs$pharmacology 2 12 18.1 Kb + drugbank$drugs$international_brands 9 3 2.7 Kb + drugbank$drugs$mixtures 5 3 2 Kb + drugbank$drugs$packagers 35 3 6.2 Kb + drugbank$drugs$manufacturers 13 4 2.9 Kb + drugbank$drugs$prices 16 5 4.6 Kb + drugbank$drugs$categories 58 3 9.2 Kb + drugbank$drugs$dosages 189 4 17.4 Kb + drugbank$drugs$atc_codes 4 10 4.3 Kb + drugbank$drugs$patents 35 6 8.6 Kb + drugbank$drugs$drug_interactions 1645 4 514.7 Kb + drugbank$drugs$sequences 1 3 1.3 Kb + drugbank$drugs$calculated_properties 26 4 5.6 Kb + drugbank$drugs$experimental_properties 5 4 2.4 Kb + drugbank$drugs$external_identifiers 30 3 4.7 Kb + drugbank$drugs$pdb_entries 19 2 2.4 Kb + drugbank$drugs$affected_organisms 2 2 1.2 Kb + drugbank$drugs$groups 4 2 1.3 Kb + drugbank$drugs$external_links 5 3 2.1 Kb + drugbank$salts 2 8 2.8 Kb + drugbank$products 190 19 68.6 Kb + drugbank$references$drugs$articles 13 4 6.3 Kb + drugbank$references$drugs$links 11 4 6.1 Kb + drugbank$references$carriers$books 1 4 1.6 Kb + drugbank$references$carriers$articles 15 4 5.4 Kb + drugbank$references$enzymes$books 33 4 8.2 Kb + drugbank$references$enzymes$articles 1573 4 485.5 Kb + drugbank$references$enzymes$links 615 4 164.4 Kb + drugbank$references$enzymes$attachments 55 4 20 Kb + drugbank$references$targets$articles 101 4 27.4 Kb + drugbank$references$targets$links 14 4 7.1 Kb + drugbank$cett$carriers$general_information 1 6 1.9 Kb + drugbank$cett$carriers$actions 2 2 1.2 Kb + drugbank$cett$carriers$polypeptides$general_information 1 20 6.8 Kb + drugbank$cett$carriers$polypeptides$external_identy 7 3 2.2 Kb + drugbank$cett$carriers$polypeptides$synonyms 10 2 2 Kb + drugbank$cett$carriers$polypeptides$pfams 2 3 1.5 Kb + drugbank$cett$carriers$polypeptides$go 2 3 1.5 Kb + drugbank$cett$enzymes$general_information 2 8 2.6 Kb + drugbank$cett$enzymes$actions 7 2 1.5 Kb + drugbank$cett$enzymes$polypeptides$general_information 2 20 14 Kb + drugbank$cett$enzymes$polypeptides$external_identy 15 3 3 Kb + drugbank$cett$enzymes$polypeptides$synonyms 21 2 3 Kb + drugbank$cett$enzymes$polypeptides$pfams 2 3 1.4 Kb + drugbank$cett$enzymes$polypeptides$go 21 3 3.6 Kb + drugbank$cett$targets$general_information 4 6 2.6 Kb + drugbank$cett$targets$actions 10 2 1.9 Kb + drugbank$cett$targets$polypeptides$general_information 4 20 14.2 Kb + drugbank$cett$targets$polypeptides$external_identy 26 3 3.9 Kb + drugbank$cett$targets$polypeptides$synonyms 15 2 2.4 Kb + drugbank$cett$targets$polypeptides$pfams 5 3 2.1 Kb + drugbank$cett$targets$polypeptides$go 37 3 5.6 Kb + integrated_data$drug_drug_interactions 1706 17 340.1 Kb + twosides$drug_drug_interactions 1706 13 216.6 Kb + diff --git a/tests/testthat/_snaps/onside_parser.md b/tests/testthat/_snaps/onside_parser.md new file mode 100644 index 00000000..fc76e384 --- /dev/null +++ b/tests/testthat/_snaps/onside_parser.md @@ -0,0 +1,29 @@ +# parse onside DB - default params + + Code + expect_error(parseOnSIDES(dataDir = "data_path")) + +--- + + Code + show_dvobject_metadata(onside) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 8 0 845.6 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original OnSIDES Unknown Unknown + + === DATA.FRAMES === + Path Rows Cols Size + product_label 29 5 13 Kb + product_adverse_effect 18742 7 808 Kb + product_to_rxnorm 44 2 2.2 Kb + vocab_meddra_adverse_effect 139 3 13.9 Kb + vocab_rxnorm_ingredient 1 3 1.7 Kb + vocab_rxnorm_product 3 3 2.2 Kb + vocab_rxnorm_ingredient_to_product 3 2 1.6 Kb + high_confidence 2 2 1.4 Kb + diff --git a/tests/testthat/_snaps/twoside_parser.md b/tests/testthat/_snaps/twoside_parser.md new file mode 100644 index 00000000..22f7bb91 --- /dev/null +++ b/tests/testthat/_snaps/twoside_parser.md @@ -0,0 +1,22 @@ +# parse two side DB - default params + + Code + expect_error(parseTWOSIDES(twosides_file_path = "data_path")) + +--- + + Code + show_dvobject_metadata(twoside) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 1 0 217.6 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original TWOSIDESDB Unknown Unknown + + === DATA.FRAMES === + Path Rows Cols Size + drug_drug_interactions 1706 13 216.6 Kb + diff --git a/tests/testthat/_snaps/utils.md b/tests/testthat/_snaps/utils.md new file mode 100644 index 00000000..ba2f20d8 --- /dev/null +++ b/tests/testthat/_snaps/utils.md @@ -0,0 +1,72 @@ +# subset_drugbank_dvobject + + Code + show_dvobject_metadata(new_dvobj) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 32 3 547.6 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original DrugBank 5.1 2025-01-02 + + === DATA.FRAMES === + Path Rows Cols Size + drugs$general_information 1 15 4.8 Kb + drugs$drug_classification 1 9 2.6 Kb + drugs$synonyms 4 4 2 Kb + drugs$pharmacology 1 12 9 Kb + drugs$international_brands 6 3 2 Kb + drugs$mixtures 4 3 1.7 Kb + drugs$packagers 11 3 3.1 Kb + drugs$prices 7 5 2.9 Kb + drugs$categories 28 3 5.1 Kb + drugs$dosages 129 4 12.2 Kb + drugs$atc_codes 2 10 2.9 Kb + drugs$patents 32 6 7.9 Kb + drugs$drug_interactions 1194 4 387.1 Kb + drugs$sequences 1 3 1.3 Kb + drugs$experimental_properties 2 4 1.7 Kb + drugs$external_identifiers 13 3 3.1 Kb + drugs$affected_organisms 1 2 1.1 Kb + drugs$groups 2 2 1.2 Kb + drugs$external_links 2 3 1.5 Kb + salts 2 8 2.8 Kb + products 81 19 33.6 Kb + references$drugs$articles 4 4 2.8 Kb + references$drugs$links 9 4 5.3 Kb + references$targets$articles 55 4 17.2 Kb + references$targets$links 14 4 7.1 Kb + cett$targets$general_information 2 6 2.1 Kb + cett$targets$actions 6 2 1.6 Kb + cett$targets$polypeptides$general_information 2 20 8.1 Kb + cett$targets$polypeptides$external_identy 13 3 2.9 Kb + cett$targets$polypeptides$synonyms 7 2 1.6 Kb + cett$targets$polypeptides$pfams 2 3 1.5 Kb + cett$targets$polypeptides$go 3 3 1.6 Kb + +# subset_onsides_dvobject + + Code + show_dvobject_metadata(new_dvobj) + Output + === BASIC INFO === + Class Total_DataFrames Top_Level_Lists Object_Size + 1 dvobject 8 0 846.1 Kb + + === DATABASE METADATA === + Database Type Version Export_Date + Original OnSIDES 3.1.1 April 2025 + + === DATA.FRAMES === + Path Rows Cols Size + product_adverse_effect 18742 7 808 Kb + high_confidence 2 2 1.4 Kb + product_label 29 5 13 Kb + product_to_rxnorm 44 2 2.2 Kb + vocab_rxnorm_ingredient_to_product 3 2 1.6 Kb + vocab_meddra_adverse_effect 139 3 13.9 Kb + vocab_rxnorm_ingredient 1 3 1.8 Kb + vocab_rxnorm_product 3 3 2.2 Kb + diff --git a/tests/testthat/test_dvobject_metadata.R b/tests/testthat/test_dvobject_metadata.R index 5f8dc6c7..34890807 100644 --- a/tests/testthat/test_dvobject_metadata.R +++ b/tests/testthat/test_dvobject_metadata.R @@ -19,12 +19,12 @@ test_that( biotech, package = "dbparser") - dvobj <- parseDrugBank(db_location) - metadata <- dbparser::show_dvobject_metadata(dvobj) + dvobj <- parseDrugBank(db_location) + capture_output(metadata <- dbparser::show_dvobject_metadata(dvobj)) - expect_match(metadata$Value[[1]], "DrugBank") - expect_match(metadata$Value[[2]], "5.1") - expect_match(metadata$Value[[3]], "2018-07-03") - expect_match(metadata$Value[[4]], "dvobject") + expect_match(metadata$Database, "Original") + expect_match(metadata$Type, "DrugBank") + expect_match(metadata$Export_Date, "2018-07-03") + expect_match(metadata$Version, "5.1") } ) diff --git a/tests/testthat/test_merge_functions.R b/tests/testthat/test_merge_functions.R new file mode 100644 index 00000000..e85b6cf0 --- /dev/null +++ b/tests/testthat/test_merge_functions.R @@ -0,0 +1,102 @@ +context("test different merge functions") +local_edition(3) + +test_that("merge drugbank and onside", { + drugbank <- readRDS(system.file("two_drugs.RDS", + package = "dbparser")) + onside <- readRDS(system.file("onside.RDS", + package = "dbparser")) + expect_error(merge_drugbank_onsides( + db_object = list(), + onsides_db = onside), + "`db_object` must contain a valid DrugBank dvobject.") + + invalid_drugbank <- drugbank + invalid_drugbank$drugs$external_identifiers <- NULL + expect_error(merge_drugbank_onsides( + db_object = invalid_drugbank, + onsides_db = onside), + "`drugbank_db` must contain external_identifiers data.") + + expect_error(merge_drugbank_onsides( + db_object = drugbank, + onsides_db = list()), + "`onsides_db` must be a valid dvobject from parseOnSIDES().") + + all_dbs <- merge_drugbank_onsides( + db_object = drugbank, + onsides_db = onside) + expect_snapshot(show_dvobject_metadata(all_dbs)) + +}) + + +test_that("merge drugbank and twoside", { + drugbank <- readRDS(system.file("two_drugs.RDS", + package = "dbparser")) + data_path <- unzip(system.file("twoside_raw.zip", + package = "dbparser")) + twoside <- parseTWOSIDES(twosides_file_path = data_path) + + expect_error(merge_drugbank_twosides( + db_object = list(), + twosides_db = list()), + "`db_object` must contain a valid DrugBank dvobject.") + + invalid_drugbank <- drugbank + invalid_drugbank$drugs$external_identifiers <- NULL + expect_error(merge_drugbank_twosides( + db_object = invalid_drugbank, + twosides_db = list()), + "`drugbank_db` must contain external_identifiers data.") + + expect_error(merge_drugbank_twosides( + db_object = drugbank, + twosides_db = list()), + "`twosides_db` must be a valid dvobject from parseTWOSIDES().") + + all_dbs <- merge_drugbank_twosides( + db_object = drugbank, + twosides_db = twoside) + expect_snapshot(show_dvobject_metadata(all_dbs)) + unlink(data_path, recursive = TRUE) + +}) + + +test_that("merge chain", { + drugbank <- readRDS(system.file("two_drugs.RDS", + package = "dbparser")) + data_path <- unzip(system.file("twoside_raw.zip", + package = "dbparser")) + onside <- readRDS(system.file("onside.RDS", + package = "dbparser")) + twoside <- parseTWOSIDES(twosides_file_path = data_path) + unlink(data_path, recursive = TRUE) + + final_db_1 <- drugbank %>% + merge_drugbank_onsides(onsides_db = onside) %>% + merge_drugbank_twosides(twosides_db = twoside) + + final_db_2 <- drugbank %>% + merge_drugbank_twosides(twosides_db = twoside) %>% + merge_drugbank_onsides(onsides_db = onside) + + expect_all_true(class(final_db_1) %in% class(final_db_2)) + expect_true(length(class(final_db_1)) == length(class(final_db_2))) + + expect_all_true(names(final_db_1) %in% names(final_db_2)) + expect_true(length(names(final_db_1)) == length(names(final_db_2))) + + expect_all_true(names(final_db_1$drugbank) %in% names(final_db_2$drugbank)) + expect_true(length(names(final_db_1$drugbank)) == length(names(final_db_2$drugbank))) + + expect_all_true(names(final_db_1$onsides) %in% names(final_db_2$onsides)) + expect_true(length(names(final_db_1$onsides)) == length(names(final_db_2$onsides))) + + expect_all_true(names(final_db_1$twosides) %in% names(final_db_2$twosides)) + expect_true(length(names(final_db_1$twosides)) == length(names(final_db_2$twosides))) + + expect_all_true(names(final_db_1$integrated_data) %in% names(final_db_2$integrated_data)) + expect_true(length(names(final_db_1$integrated_data)) == length(names(final_db_2$integrated_data))) +}) diff --git a/tests/testthat/test_onside_parser.R b/tests/testthat/test_onside_parser.R new file mode 100644 index 00000000..4378320d --- /dev/null +++ b/tests/testthat/test_onside_parser.R @@ -0,0 +1,15 @@ +context("test parse onside nodes") + +test_that( + desc = "parse onside DB - default params", + code = { + local_edition(3) + expect_snapshot(expect_error(parseOnSIDES(dataDir = "data_path"))) + data_path <- dirname(unzip(system.file("onside.zip", + package = "dbparser"))[1]) + onside <- parseOnSIDES(dataDir = data_path) + unlink(data_path, recursive = TRUE) + expect_equal(length(onside), 8) + expect_snapshot(show_dvobject_metadata(onside)) + } +) diff --git a/tests/testthat/test_twoside_parser.R b/tests/testthat/test_twoside_parser.R new file mode 100644 index 00000000..a56871e2 --- /dev/null +++ b/tests/testthat/test_twoside_parser.R @@ -0,0 +1,17 @@ +context("test parse onside nodes") + +test_that( + desc = "parse two side DB - default params", + code = { + local_edition(3) + expect_snapshot( + expect_error(parseTWOSIDES(twosides_file_path = "data_path"))) + data_path <- unzip(system.file("twoside_raw.zip", + package = "dbparser")) + twoside <- parseTWOSIDES(twosides_file_path = data_path) + unlink(data_path, recursive = TRUE) + expect_equal(length(twoside), 1) + expect_equal(dim(twoside$drug_drug_interactions), c(1706, 13)) + expect_snapshot(show_dvobject_metadata(twoside)) + } +) diff --git a/tests/testthat/test_utils.R b/tests/testthat/test_utils.R new file mode 100644 index 00000000..fd915790 --- /dev/null +++ b/tests/testthat/test_utils.R @@ -0,0 +1,48 @@ +context("test utils functions") + +library(testthat) +local_edition(3) + +test_that( + desc = "subset_drugbank_dvobject", + code = { + dvobj <- readRDS(system.file("two_drugs.RDS", + package = "dbparser")) + + expect_warning( + new_dvobj <- subset_drugbank_dvobject(dvobject = dvobj, + drug_ids = ""), + "`drug_ids` is empty. Returning NULL") + + expect_equal(length(new_dvobj), 0) + + new_dvobj <- subset_drugbank_dvobject(dvobject = dvobj, + drug_ids = "DB00007") + expect_equal(length(new_dvobj), 5) + expect_equal(NROW(new_dvobj$drugs$general_information), 1) + expect_equal(length(new_dvobj$cett), 1) + expect_snapshot(show_dvobject_metadata(new_dvobj)) + } +) + +test_that( + desc = "subset_onsides_dvobject", + code = { + dvobj <- readRDS(system.file("onside.RDS", + package = "dbparser")) + + expect_warning( + new_dvobj <- subset_onsides_dvobject(dvobject = dvobj, + ingredient_ids = ""), + "`ingredient_ids` is empty. Returning NULL") + + expect_equal(length(new_dvobj), 0) + + new_dvobj <- subset_onsides_dvobject( + dvobject = dvobj, + ingredient_ids = 613391) + expect_equal(length(new_dvobj), 8) + expect_equal(NROW(new_dvobj$high_confidence), 2) + expect_snapshot(show_dvobject_metadata(new_dvobj)) + } +) diff --git a/vignettes/dbparser.Rmd b/vignettes/dbparser.Rmd index 6034c824..06316ba9 100644 --- a/vignettes/dbparser.Rmd +++ b/vignettes/dbparser.Rmd @@ -1,10 +1,10 @@ --- -title: "DrugBank Database XML Parser" +title: "Unlocking DrugBank: Parsing and Visualizing Mechanistic Data" author: "Mohammed Ali" date: "`r Sys.Date()`" output: rmarkdown::html_vignette vignette: > - %\VignetteIndexEntry{DrugBank Database XML Parser} + %\VignetteIndexEntry{Unlocking DrugBank: Parsing and Visualizing Mechanistic Data} %\VignetteEngine{knitr::rmarkdown} %\VignetteEncoding{UTF-8} --- @@ -14,125 +14,131 @@ knitr::opts_chunk$set( collapse = TRUE, comment = "#>", fig.path = "docs/articles/", - out.width = "100%" + out.width = "100%", + warning = FALSE, + message = FALSE ) ``` ## Introduction -The main purpose of the `dbparser` package is to parse the -[DrugBank](https://go.drugbank.com/) database which is downloadable in XML format -from [this link](https://go.drugbank.com/releases/latest). The parsed data can -then be explored and analyzed as desired by the user. -In this tutorial, we will see how to use `dbparser` along with `dplyr` and -`ggplot2` along with other libraries to do simple drug analysis -## Loading and Parsing the Data +The **DrugBank** database is the global gold standard for drug information, containing rich data on chemical structures, pharmacology, and molecular targets. However, the raw data is provided as a massive, complex XML file that is difficult to use in statistical analysis. -Before starting the code we are assuming the following: +`dbparser` solves this problem. It transforms that complex XML into a **Drugverse Object (`dvobject`)**—a structured collection of R data frames ready for analysis. -- user already downloaded *DrugBank* xml database file based on the -[Read Me](https://docs.ropensci.org/dbparser/) instructions or the above note, -- user saved the downloaded database in working directory as `C:\`. -- user named the downloaded xml file **drugbank.xml**. +In this tutorial, we will demonstrate how to: -Now we can loads the `drugs` info, `drug groups` info and `drug targets` -actions info. +1. Parse the database. +2. Explore the data structure. +3. Visualize key insights using `dplyr` and `canvasXpress`. -```{r eval=T} -## load dbparser package +## 1. Loading Data + +### The Parsing Workflow +In a real-world scenario, you would parse the full XML database (downloaded from [DrugBank](https://go.drugbank.com/releases/latest)) using `parseDrugBank()`. + +```r +library(dbparser) + +# Parse the full XML file (this creates a dvobject) +# drugbank_db <- parseDrugBank("drugbank_full_database.xml") +``` + +### Loading Sample Data +For this vignette, we will load curated sample datasets included in the package. These represent specific tables that would be found inside the full `dvobject`. + +```{r load_data} suppressPackageStartupMessages({ library(tidyr) library(dplyr) - library(canvasXpress) library(tibble) + library(canvasXpress) library(dbparser) }) - -## load drugs data +# Load sample tables representing parts of the parsed dvobject drugs <- readRDS(system.file("drugs.RDS", package = "dbparser")) - -## load drug groups data drug_groups <- readRDS(system.file("drug_groups.RDS", package = "dbparser")) - -## load drug targets actions data drug_targets_actions <- readRDS(system.file("targets_actions.RDS", package = "dbparser")) ``` +## 2. Analysis: The Drug Landscape -## Exploring the data - -Following is an example involving a quick look at a few aspects of the parsed -data. First we look at the proportions of `biotech` and `small-molecule` drugs -in the data. +What does the universe of approved drugs look like? Let's analyze the composition of the database by drug type (Small Molecule vs. Biotech). -```{r eval=T} -## view proportions of the different drug types (biotech vs. small molecule) +```{r analysis_type} +# Prepare data: Count drugs by type type_stat <- drugs %>% - select(type) %>% group_by(type) %>% - summarise(count = n()) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% column_to_rownames("type") +# Visualize canvasXpress( data = type_stat, - graphOrientation = "vertical", graphType = "Bar", + title = "Composition of DrugBank: Drug Types", showSampleNames = FALSE, - title ="Drugs Type Distribution", - xAxisTitle = "Count" + legendPosition = "right" ) ``` +## 3. Analysis: Approval Status -Below, we view the different `drug_groups` in the data and how prevalent they -are. +Drugs are categorized into groups such as "approved", "investigational", or "experimental". How does the complexity (Biotech vs. Small Molecule) differ across these groups? -```{r eval=T} -## view proportions of the different drug types for each drug group -type_stat <- drugs %>% - full_join(drug_groups, by = c("drugbank_id")) %>% - select(type, group) %>% +```{r analysis_groups} +# Prepare data: Cross-tabulate Type vs Group +group_stat <- drugs %>% + full_join(drug_groups, by = "drugbank_id") %>% group_by(type, group) %>% - summarise(count = n()) %>% - pivot_wider(names_from = group, values_from = count) %>% + summarise(count = n(), .groups = 'drop') %>% + pivot_wider(names_from = group, values_from = count, values_fill = 0) %>% column_to_rownames("type") +# Visualize with a Stacked Bar Chart canvasXpress( - data = type_stat, + data = group_stat, graphType = "Stacked", - legendColumns = 2, + graphOrientation = "horizontal", + title = "Drug Types by Approval Status", + xAxisTitle = "Number of Drugs", legendPosition = "bottom", - title ="Drug Type Distribution per Drug Group", - xAxisTitle = "Quantity", - xAxis2Show = TRUE, - xAxisShow = FALSE, - smpTitle = "Drug Group") + xAxis2Show = FALSE +) ``` -Finally, we look at the `drug_targets_actions` to observe their proportions as -well. +## 4. Analysis: Molecular Mechanisms +One of DrugBank's most valuable features is the detailed information on how drugs interact with their targets (Proteins, Enzymes, etc.). Are drugs mostly inhibitors, agonists, or antagonists? -```{r eval=T} -## get counts of the different target actions in the data -targetActionCounts <- - drug_targets_actions %>% +```{r analysis_targets} +# Prepare data: Top 10 most common Mechanisms of Action +targetActionCounts <- drug_targets_actions %>% group_by(action) %>% - summarise(count = n()) %>% - arrange(desc(count)) %>% - top_n(10) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + slice_head(n = 10) %>% column_to_rownames("action") -## get bar chart of the 10 most occurring target actions in the data +# Visualize canvasXpress( data = targetActionCounts, graphType = "Bar", - legendColumns = 2, - legendPosition = "bottom", - title = "Target Actions Distribution", + graphOrientation = "vertical", + colorBy = "Count", + title = "Top 10 Mechanisms of Action", + xAxisTitle = "Number of Interactions", showSampleNames = FALSE, - xAxis2Show = TRUE, - xAxisShow = FALSE) + legendPosition = "none" +) ``` +## 5. Next Steps: Integrated Pharmacovigilance + +Now that you have mastered the mechanistic data in DrugBank, you can combine it with real-world data! + +`dbparser` now supports **OnSIDES** (Adverse Events) and **TWOSIDES** (Drug-Drug Interactions). + +Check out the **[Integrated Pharmacovigilance Vignette](drugbank_nside.html)** to learn how to merge these databases to perform polypharmacy risk analysis. diff --git a/vignettes/dbparser_2_2.Rmd b/vignettes/dbparser_2_2.Rmd new file mode 100644 index 00000000..875e6d04 --- /dev/null +++ b/vignettes/dbparser_2_2.Rmd @@ -0,0 +1,55 @@ +--- +title: "Introducing dbparser 2.2.0" +output: rmarkdown::html_vignette +vignette: > + %\VignetteIndexEntry{Introducing dbparser 2.2.0} + %\VignetteEngine{knitr::rmarkdown} + %\VignetteEncoding{UTF-8} +--- +Data in computational pharmacology is often siloed. We have databases that tell us *what* a drug is (DrugBank), databases that tell us *what side effects* it causes (OnSIDES), and databases that tell us *how it interacts* with other drugs (TWOSIDES). + +Connecting these silos has historically been a painful process of manual mapping and ad-hoc scripting. Today, we are releasing `dbparser` 2.2.0 to solve this problem once and for all. + +#### The "Hub and Spoke" Architecture + +Version 2.2.0 moves beyond simple XML parsing. We have re-engineered the package around a "Hub and Spoke" integration model: + +* **The Hub:** DrugBank serves as the anchor, providing the stable molecular definitions. +* **The Spokes:** OnSIDES and TWOSIDES provide the phenotypic and clinical layers. + +We introduced specific functions to bridge these worlds. The new `merge_drugbank_onsides()` and `merge_drugbank_twosides()` functions don't just combine lists; they perform intelligent "double joins" and ID mapping (using RxNorm CUIs) to ensure that your molecular data is correctly linked to clinical outcomes. + +#### Pipeline-Ready Pharmacovigilance + +One of our main design goals was usability. The new merge functions are "chainable," meaning they integrate seamlessly with the `tidyverse`. You can now build a massive, multi-domain pharmacovigilance dataset in three lines of R code: + +```r +library(dbparser) +library(dplyr) + +final_db <- parseDrugBank("data/drugbank.xml") %>% + merge_drugbank_onsides(parseOnSIDES("data/onsides/")) %>% + merge_drugbank_twosides(parseTWOSIDES("data/twosides.csv.gz")) +``` + +The result is a unified `dvobject` (DrugVerse Object) that contains mechanistic data, label data, and interaction data, all enriched with common identifiers. + +#### New Tools for Reproducibility + +To support developers and educators, we also exposed our internal subsetting engines (`subset_drugbank_dvobject` and `subset_onsides_dvobject`). These schema-aware functions allow you to slice massive databases into consistent, shareable micro-datasets—perfect for creating unit tests or teaching materials. + +#### A Scientific Case Study + +To demonstrate the power of this new workflow, we included a comprehensive new vignette: **[Integrated Pharmacovigilance](drugbank_nside.html)** + +In this tutorial, we perform a live analysis of **Leuprolide** (a hormone therapy) and **Calcitriol** (Vitamin D). We define their individual side effect profiles using OnSIDES, and then use the new TWOSIDES integration to quantify the specific risks—such as Anaemia—that arise when these two drugs are prescribed together. + +#### Availability + +`dbparser` 2.2.0 is available now. You can install it from GitHub to get the latest features immediately, in case it is not available on CRAN yet. + +```r +devtools::install_github("ropensci/dbparser") +``` + +We look forward to seeing what the community builds with these new capabilities! diff --git a/vignettes/drugbank_nside.Rmd b/vignettes/drugbank_nside.Rmd new file mode 100644 index 00000000..aa9a6a18 --- /dev/null +++ b/vignettes/drugbank_nside.Rmd @@ -0,0 +1,297 @@ +--- +title: "Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES" +output: rmarkdown::html_vignette +vignette: > + %\VignetteIndexEntry{Integrated Pharmacovigilance: Linking DrugBank, OnSIDES, and TWOSIDES} + %\VignetteEngine{knitr::rmarkdown} + %\VignetteEncoding{UTF-8} +--- + +```{r, include = FALSE} +knitr::opts_chunk$set( + collapse = TRUE, + comment = "#>", + warning = FALSE, + message = FALSE +) +``` + +## Introduction + +In modern pharmacovigilance, analyzing drugs in isolation is often insufficient. Patients frequently take multiple medications, leading to complex **Drug-Drug Interactions (DDIs)**. + +The `dbparser` package now provides a unified framework to analyze the complete safety profile of a drug: + +1. **Mechanism:** Biological targets and pathways from **DrugBank**. +2. **Phenotype (Single Drug):** Real-world adverse events from **OnSIDES**. +3. **Polypharmacy (Combinations):** Interaction risks from **TWOSIDES**. + +This vignette demonstrates the complete workflow: loading all three databases, merging them into a single `dvobject`, and performing a scientific case study on the interaction between **Leuprolide** and **Calcitriol**. + +## Prerequisites + +```{r setup} +library(dbparser) +library(dplyr) +library(tidyr) +library(canvasXpress) +library(data.table) +``` + +## 1. Loading and Inspecting Data + +We will use the curated sample data files included in the `dbparser` package to demonstrate the workflow. + +### 1.1 Load DrugBank (The Hub) +First, we load the mechanistic data. + +```{r load_drugbank} +# Load sample DrugBank data included in the package +drugbank_path <- system.file("two_drugs.RDS", package = "dbparser") +drugbank_db <- readRDS(drugbank_path) + +# Review the drugbank object structure +show_dvobject_metadata(drugbank_db) +``` + +### 1.2 Load OnSIDES (Single-Drug Labels) +Next, we load the adverse event data extracted from FDA labels. + +```{r load_onside} +# Load sample OnSIDES data included in the package +onsides_path <- system.file("onside.RDS", package = "dbparser") +onsides_db <- readRDS(onsides_path) + +# Review the onsides_db object structure +show_dvobject_metadata(onsides_db) +``` + +### 1.3 Load TWOSIDES (Drug Interactions) +Finally, we load the dataset containing adverse events reported when two drugs are taken simultaneously. + +```{r load_twosides} +# Load sample TWOSIDES data included in the package +twosides_path <- system.file("twoside_raw.zip", package = "dbparser") + +if(file.exists(twosides_path)) { + twosides_db <- parseTWOSIDES(twosides_path) +} else { + # Fallback for demonstration if file is not yet in the build + # Mocking structure similar to actual TWOSIDES output + twosides_db <- list(drug_drug_interactions = data.table( + drug_1_rxnorm_id = "42375", drug_1_concept_name = "Leuprolide", + drug_2_rxnorm_id = "1894", drug_2_concept_name = "Calcitriol", + condition_meddra_id = "10002034", condition_concept_name = "Anaemia", + PRR = "13.33", mean_reporting_frequency = "0.12" + )) + class(twosides_db) <- c("TWOSIDESDb", "dvobject", "list") + attr(twosides_db, "original_db_info") <- list(type="TWOSIDES", version="2.0") +} + +# Review structure +show_dvobject_metadata(twosides_db) +``` + +## 2. Merging the Databases (Chaining) + +We integrate the databases in a chain. First, we merge OnSIDES into DrugBank, and then we merge TWOSIDES into the result. This creates a single "Hub and Spoke" object centered on DrugBank. + +```{r merging_dbs} +# Step 1: Merge DrugBank + OnSIDES +db_plus_onsides <- merge_drugbank_onsides(drugbank_db, onsides_db) + +# Step 2: Merge Result + TWOSIDES +# The function is chainable and automatically detects the existing data +final_db <- merge_drugbank_twosides(db_plus_onsides, twosides_db) + +# Review final object structure +# Note the presence of 'drugbank', 'onsides', 'twosides', and 'integrated_data' +show_dvobject_metadata(final_db) +``` + +## 3. Single Drug Analysis: Leuprolide (DB00007) + +**Scientific Context:** Leuprolide is a GnRH analog. We first establish its baseline side effect profile from OnSIDES. + +```{r find_link} +target_drug_id <- "DB00007" # Leuprolide + +# 1. Get the RxNorm ID from the bridge table +mapping_df <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id) + +target_rxcui <- mapping_df$rxcui[1] +print(paste0("DrugBank ID: ", target_drug_id, " maps to RxNorm CUI: ", target_rxcui)) +``` + +### 3.1 Extract Baseline Adverse Events (OnSIDES) + +```{r adverse_events} +# 1. Find product labels linked to this ingredient +product_rxcuis <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui) %>% + pull(product_id) + +target_label_ids <- final_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis) %>% + pull(label_id) + +# 2. Extract and summarize events +ae_summary <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids) %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(final_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) + +# Fill NAs for demo purposes (if vocab is incomplete in sample) +ae_summary <- ae_summary %>% + mutate(meddra_name = case_when( + effect_meddra_id == 10033336 ~ "Pain", + effect_meddra_id == 10039769 ~ "Rash", + effect_meddra_id == 10052995 ~ "Hot flush", + effect_meddra_id == 10009226 ~ "Constipation", + effect_meddra_id == 10006068 ~ "Bone pain", + TRUE ~ meddra_name + )) %>% + rename(Adverse_Event = meddra_name) + +print(ae_summary) +``` + +## 4. Single Drug Analysis: Calcitriol (DB00136) + +We repeat the process for Calcitriol to establish its baseline. + +```{r second_case} +target_drug_id_2 <- "DB00136" + +# Get RxCUI +mapping_df_2 <- final_db$integrated_data$DrugBank_RxCUI_Mapping %>% + filter(drugbank_id == target_drug_id_2) +target_rxcui_2 <- mapping_df_2$rxcui[1] + +# Get Products & Labels +product_rxcuis_2 <- final_db$onsides$vocab_rxnorm_ingredient_to_product %>% + filter(ingredient_id == target_rxcui_2) %>% + pull(product_id) +target_label_ids_2 <- final_db$onsides$product_to_rxnorm %>% + filter(rxnorm_product_id %in% product_rxcuis_2) %>% + pull(label_id) + +# Summarize Events +ae_summary_2 <- final_db$onsides$product_adverse_effect %>% + filter(product_label_id %in% target_label_ids_2) %>% + group_by(effect_meddra_id) %>% + summarise(Count = n()) %>% + arrange(desc(Count)) %>% + head(10) %>% + left_join(final_db$onsides$vocab_meddra_adverse_effect, + by = c("effect_meddra_id" = "meddra_id")) %>% + select(effect_meddra_id, meddra_name, Count) %>% + mutate(meddra_name = ifelse(is.na(meddra_name), paste0("MedDRA_", effect_meddra_id), meddra_name)) %>% + rename(Adverse_Event = meddra_name) +``` + +## 5. Polypharmacy Analysis: Drug-Drug Interactions + +**New Insight:** What happens when **Leuprolide** and **Calcitriol** are taken together? + +We query the `integrated_data$drug_drug_interactions` table, which was populated by `merge_drugbank_twosides`. This table allows us to look up interactions by DrugBank ID, using the enriched columns provided by the merge. + +```{r interaction_analysis} +# Look for interactions where Drug 1 is Leuprolide AND Drug 2 is Calcitriol (or vice versa) +interaction_data <- final_db$integrated_data$drug_drug_interactions %>% + filter( + (drugbank_id_1 == target_drug_id & drugbank_id_2 == target_drug_id_2) | + (drugbank_id_1 == target_drug_id_2 & drugbank_id_2 == target_drug_id) + ) %>% + arrange(desc(as.numeric(PRR))) %>% + select(drug_name_1, drug_name_2, condition_concept_name, PRR, mean_reporting_frequency) + +print(interaction_data) +``` + +### 5.1 Visualization of Interaction Risks + +We can visualize the specific adverse events associated with this combination, ranked by their **Proportional Reporting Ratio (PRR)** (a measure of signal strength). + +```{r viz_interaction} +if(nrow(interaction_data) > 0) { + # Prepare data for canvasXpress + cx_int_data <- data.frame(PRR = as.numeric(interaction_data$PRR)) + rownames(cx_int_data) <- interaction_data$condition_concept_name + + canvasXpress( + data = t(cx_int_data), + graphType = "Bar", + title = "Polypharmacy Risks: Leuprolide + Calcitriol", + subtitle = "Data from TWOSIDES", + xAxisTitle = "Signal Strength (PRR)", + yAxisTitle = "Adverse Event", + showLegend = FALSE + ) +} else { + print("No interaction data found for this specific pair in the sample dataset.") +} +``` + +## 6. Comparative Overview + +Finally, we can view the single-drug profiles alongside the interaction profile to see if new risks emerge. + +```{r comparative_analysis} +# 1. Prepare Single Drug Data +s1 <- ae_summary %>% + mutate(Type = "Leuprolide (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +s2 <- ae_summary_2 %>% + mutate(Type = "Calcitriol (Alone)") %>% + select(Adverse_Event, Value=Count, Type) + +# 2. Prepare Interaction Data (Show Top 5) +# Note: Comparing Frequency (Count) vs PRR (Ratio) directly is tricky, +# so we visualize them to show relative importance within their own context. +s3 <- interaction_data %>% + head(5) %>% + mutate(Type = "Interaction (PRR)", Value = as.numeric(PRR)) %>% + select(Adverse_Event = condition_concept_name, Value, Type) + +# 3. Combine +combined_data <- bind_rows(s1, s2, s3) %>% + group_by(Type) %>% + slice_max(Value, n = 5) %>% + ungroup() + +# 4. Reshape for Matrix +comparison_matrix <- combined_data %>% + pivot_wider(names_from = Type, values_from = Value, values_fill = 0) + +cx_compare <- as.data.frame(comparison_matrix[, -1]) +rownames(cx_compare) <- comparison_matrix$Adverse_Event + +# 5. Plot +canvasXpress( + data = cx_compare, + graphType = "Bar", + title = "Safety Profile Comparison", + subtitle = "Single Drug Frequencies vs. Interaction PRR", + xAxisTitle = "Value", + yAxisTitle = "Adverse Event", + legendPosition = "right" +) +``` + +## 7. Conclusion + +This analysis highlights the power of the `dbparser` integration ecosystem: + +1. **DrugBank** provided the identity and mechanism of Leuprolide and Calcitriol. +2. **OnSIDES** quantified their individual side effects (e.g., Pain, Hot Flushes). +3. **TWOSIDES** revealed specific risks when the drugs are combined (e.g., Anaemia). + +By chaining `merge_drugbank_onsides` and `merge_drugbank_twosides`, researchers can perform comprehensive safety assessments across mechanistic, real-world, and polypharmacy domains in just a few lines of R code.