Investigate preliminary data #1
Description
one yeast, one human
use time slicing for fairness (2018 or something)
hypotheses regarding PYURF and its role in disease?
vectordb full text?
two articles to start with:
https://www.nature.com/articles/s41586-022-04765-3 (human)
https://www.nature.com/articles/nbt.3683 (yeast)
- observation: CoQ abundance is lower in PYURF-KO cells. not much is known about PYURF. fairly obvious hypothesis: presumably PYURF has something to do with producing CoQ. what are the repercussions of lowered CoQ abundance? presumably some kind of metabolic disease.
- maybe this one observation is very simple, but there's so much data they don't know what to do with it. there are probably hundreds of downregulated/upregulated metabolites/proteins in each KO cell line.
- so maybe it's reasonable to ask: for this PYURF-KO cell line, what is changing? what does it mean? can GPT recapitulate the hypothesis that CoQ production is being disrupted and can it connect that to metabolic disease?