From 556e9a7389028b268988bb3be5ca312b787c2ec6 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Mon, 23 Jun 2025 08:02:24 +0200 Subject: [PATCH 01/47] draft: blq imputation options in NCA setup --- R/PKNCA.R | 9 +- inst/shiny/modules/tab_nca.R | 61 +++--- inst/shiny/modules/tab_nca/setup.R | 62 +++--- .../modules/tab_nca/setup/data_imputation.R | 89 ++++++++ inst/shiny/modules/tab_nca/setup/settings.R | 193 +++++++++--------- 5 files changed, 250 insertions(+), 164 deletions(-) create mode 100644 inst/shiny/modules/tab_nca/setup/data_imputation.R diff --git a/R/PKNCA.R b/R/PKNCA.R index e87c3d81b..e9a9784be 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -193,7 +193,9 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter selected_profile, selected_pcspec, params, - should_impute_c0 = TRUE + should_impute_c0 = TRUE, + # PKNCA default BLQ imputation rule + blq_imputation_rule = list(first = "keep", middle = "drop", last = "keep") ) { data <- adnca_data @@ -202,6 +204,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter data$options <- list( auc.method = method, + conc.blq = blq_imputation_rule, progress = FALSE, keep_interval_cols = c("NCA_PROFILE", "DOSNOA", "type_interval"), min.hl.r.squared = 0.01 @@ -251,7 +254,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter # Impute start values if requested if (should_impute_c0) { data <- create_start_impute(data) - + # Don't impute parameters that are not AUC dependent params_auc_dep <- pknca_cdisc_terms %>% filter(grepl("auc|aumc", PKNCA) | grepl("auc", Depends)) %>% @@ -262,7 +265,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% pull(PKNCA) |> intersect(names(PKNCA::get.interval.cols())) - + all_impute_methods <- na.omit(unique(data$intervals$impute)) data$intervals <- Reduce(function(d, ti_arg) { diff --git a/inst/shiny/modules/tab_nca.R b/inst/shiny/modules/tab_nca.R index dc0759c01..00244d841 100644 --- a/inst/shiny/modules/tab_nca.R +++ b/inst/shiny/modules/tab_nca.R @@ -20,7 +20,7 @@ #' @returns `res_nca` reactive with results data object. tab_nca_ui <- function(id) { ns <- NS(id) - + fluidPage( div( class = "d-flex justify-content-between", @@ -58,27 +58,27 @@ tab_nca_ui <- function(id) { tab_nca_server <- function(id, adnca_data, grouping_vars) { moduleServer(id, function(input, output, session) { ns <- session$ns - + #' Setup session-wide object for storing data units. Units can be edited by the user on #' various steps of the workflow (pre- and post-NCA calculation) and the whole application #' should respect the units, regardless of location. session$userData$units_table <- reactiveVal(NULL) - + #' Initializes PKNCA::PKNCAdata object from pre-processed adnca data pknca_data <- reactive({ req(adnca_data()) log_trace("Creating PKNCA::data object.") - + tryCatch({ #' Create data object pknca_object <- PKNCA_create_data_object(adnca_data()) log_success("PKNCA data object created.") - + #' Enable related tabs and update the curent view if data is created succesfully. purrr::walk(c("nca", "visualisation", "tlg"), \(tab) { shinyjs::enable(selector = paste0("#page li a[data-value=", tab, "]")) }) - + pknca_object }, error = function(e) { log_error(e$message) @@ -87,25 +87,26 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { }) }) |> bindEvent(adnca_data()) - + # #' NCA Setup module nca_setup <- setup_server("nca_setup", adnca_data, pknca_data) - + processed_pknca_data <- nca_setup$processed_pknca_data settings <- nca_setup$settings slope_rules <- nca_setup$slope_rules - + output$manual_slopes <- renderTable(slope_rules$manual_slopes()) - + # List all irrelevant warnings to suppres in the NCA calculation irrelevant_regex_warnings <- c( "No intervals for data$", "^Too few points for half-life" ) - + #' Triggers NCA analysis, creating res_nca reactive res_nca <- reactive({ req(processed_pknca_data()) + withProgress(message = "Calculating NCA...", value = 0, { log_info("Calculating NCA results...") tryCatch({ @@ -113,7 +114,7 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { # from within warning handler without bleeding to global env. pknca_warn_env <- new.env() pknca_warn_env$warnings <- c() - + #' Calculate results res <- withCallingHandlers({ processed_pknca_data() %>% @@ -134,22 +135,22 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { } invokeRestart("muffleWarning") }) - + # Apply flag rules to mark results in the `exclude` column current_rules <- isolate(settings()$flags) flag_rules_to_apply <- current_rules |> purrr::keep(~ .x$is.checked) |> purrr::map(~ .x$threshold) res <- PKNCA_hl_rules_exclusion(res, flag_rules_to_apply) - + # Display unique warnings thrown by PKNCA run. purrr::walk(unique(pknca_warn_env$warnings), \(w) { w_message <- paste0("PKNCA run produced a warning: ", w) log_warn(w_message) showNotification(w_message, type = "warning", duration = 5) }) - - + + #' Apply units if (!is.null(session$userData$units_table())) { res$data$units <- session$userData$units_table() @@ -162,15 +163,15 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { mutate(PPSTRES = PPORRES * conversion_factor) %>% select(-conversion_factor) } - + updateTabsetPanel(session, "ncapanel", selected = "Results") - + log_success("NCA results calculated.") - + # Apply standard CDISC names and return the object res %>% mutate(PPTESTCD = translate_terms(PPTESTCD, "PKNCA", "PPTESTCD")) - + }, error = function(e) { log_error("Error calculating NCA results:\n{conditionMessage(e)}") showNotification(.parse_pknca_error(e), type = "error", duration = NULL) @@ -179,7 +180,7 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { }) }) |> bindEvent(input$nca) - + #' Show slopes results output$slope_results <- DT::renderDataTable({ req(res_nca()) @@ -200,18 +201,18 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { formatStyle("Exclude", target = "row", backgroundColor = styleEqual(NA, NA, default = "#f5b4b4")) }) - + nca_results_server("nca_results", processed_pknca_data, res_nca, settings, grouping_vars) - + #' Descriptive statistics module descriptive_statistics_server("descriptive_stats", res_nca, grouping_vars) - + #' Additional analysis module additional_analysis_server("non_nca", processed_pknca_data, grouping_vars) - + #' Parameter datasets module parameter_datasets_server("parameter_datasets", res_nca) - + # return results for use in other modules res_nca }) @@ -225,7 +226,7 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { #' @returns String with html-formatted error message. .parse_pknca_error <- function(e) { msg <- conditionMessage(e) - + if (grepl("pk.calc.", msg)) { # Handle errors from PKNCA package. param_of_error <- gsub(".*'pk\\.calc\\.(.*)'.*", "\\1", msg) @@ -235,11 +236,11 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { "

", msg, "

If the error is unexpected, please report a bug." ) - + } else if (grepl("^No reason provided", msg)) { # Handle no reason provided erros from the calculation function. msg <- paste(msg, "

Please provide the reason in Setup > Slope Selector tab.") - + } else { # Handle unknown error msg <- paste0( @@ -247,6 +248,6 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { " please inspect the logs and report a bug." ) } - + HTML(gsub("\\\n", "
", msg)) } diff --git a/inst/shiny/modules/tab_nca/setup.R b/inst/shiny/modules/tab_nca/setup.R index c268f0378..39c724e1b 100644 --- a/inst/shiny/modules/tab_nca/setup.R +++ b/inst/shiny/modules/tab_nca/setup.R @@ -16,25 +16,25 @@ setup_ui <- function(id) { ns <- NS(id) - + navset_pill_list( nav_panel( "Settings", fluidRow( column(6, - fileInput( - ns("settings_upload"), - width = "100%", - label = "Upload settings", - buttonLabel = list(icon("folder"), "Browse"), - accept = ".rds" - ) + fileInput( + ns("settings_upload"), + width = "100%", + label = "Upload settings", + buttonLabel = list(icon("folder"), "Browse"), + accept = ".rds" + ) ), column(6, - downloadButton( - ns("settings_download"), - label = "Download settings" - ) + downloadButton( + ns("settings_download"), + label = "Download settings" + ) ) ), fluidRow(units_table_ui(ns("units_table"))), @@ -49,13 +49,13 @@ setup_server <- function(id, data, adnca_data) { moduleServer(id, function(input, output, session) { # Gather all settings from the appropriate module settings <- settings_server("nca_settings", data, adnca_data, settings_override) - + # Create processed data object with applied settings. - + processed_pknca_data <- reactive({ req(adnca_data(), settings()) log_trace("Updating PKNCA::data object.") - + processed_pknca_data <- PKNCA_update_data_object( adnca_data = adnca_data(), auc_data = settings()$partial_aucs, @@ -64,16 +64,17 @@ setup_server <- function(id, data, adnca_data) { selected_profile = settings()$profile, selected_pcspec = settings()$pcspec, params = settings()$parameter_selection, - should_impute_c0 = settings()$data_imputation$impute_c0 + should_impute_c0 = settings()$data_imputation$impute_c0, + blq_imputation_rule = settings()$data_imputation$blq_imputation_rule ) - + # Show bioavailability widget if it is possible to calculate if (processed_pknca_data$dose$data$std_route %>% unique() %>% length() == 2) { shinyjs::show(selector = ".bioavailability-picker") } else { shinyjs::hide(selector = ".bioavailability-picker") } - + if (nrow(processed_pknca_data$intervals) == 0) { showNotification( "All intervals were filtered. Please revise your settings", @@ -81,21 +82,21 @@ setup_server <- function(id, data, adnca_data) { duration = 10 ) } - + processed_pknca_data }) - + # Parameter unit changes option: Opens a modal message with a units table to edit units_table_server("units_table", processed_pknca_data) - + # Create version for slope plots # Only parameters required for the slope plots are set in intervals # NCA dynamic changes/filters based on user selections slopes_pknca_data <- reactive({ req(adnca_data(), settings(), settings()$profile, - settings()$analyte, settings()$pcspec) + settings()$analyte, settings()$pcspec, settings()$data_imputation$blq_imputation_rule) log_trace("Updating PKNCA::data object for slopes.") - + PKNCA_update_data_object( adnca_data = adnca_data(), auc_data = settings()$partial_aucs, @@ -105,18 +106,19 @@ setup_server <- function(id, data, adnca_data) { selected_pcspec = settings()$pcspec, params = c("lambda.z.n.points", "lambda.z.time.first", "r.squared", "adj.r.squared", "tmax"), - should_impute_c0 = settings()$data_imputation$impute_c0 + should_impute_c0 = settings()$data_imputation$impute_c0, + blq_imputation_rule = settings()$data_imputation$blq_imputation_rule ) }) - + slope_rules <- slope_selector_server( "slope_selector", slopes_pknca_data, manual_slopes_override ) - + summary_server("nca_setup_summary", processed_pknca_data) - + # Handle downloading and uploading settings output$settings_download <- downloadHandler( filename = paste0("aNCA_settings_", Sys.Date(), ".rds"), @@ -124,15 +126,15 @@ setup_server <- function(id, data, adnca_data) { saveRDS(list(settings = settings(), slope_rules = slope_rules$manual_slopes()), con) } ) - + imported_settings <- reactive({ req(input$settings_upload) readRDS(input$settings_upload$datapath) }) - + settings_override <- reactive(imported_settings()$settings) manual_slopes_override <- reactive(imported_settings()$slope_rules) - + list( processed_pknca_data = processed_pknca_data, settings = settings, diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R new file mode 100644 index 000000000..7e22d6d69 --- /dev/null +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -0,0 +1,89 @@ +data_imputation_ui <- function(id) { + ns <- NS(id) + + tagList( + input_switch( + id = ns("should_impute_c0"), + label = "Impute Concentration", + value = TRUE + ), + br(), + helpText(HTML(paste( + "Imputes a start-of-interval concentration to calculate non-observational parameters:", + "- If DOSNO = 1 & IV bolus: C0 = 0", + "- If DOSNO > 1 & not IV bolus: C0 = predose", + "- If IV bolus & monoexponential data: logslope", + "- If IV bolus & not monoexponential data: C0 = C1", + sep = "
" + ))), + br(), + selectInput( + ns("select_blq_strategy"), + "Select BLQ Imputation Strategy", + choices = c( + "tmax based imputation", + "Positional BLQ imputation", + "Set value for all BLQ" + ), + selected = "tmax based imputation" + ), + # Always render all inputs, but use conditionalPanel to show/hide + div( + style = "margin-top: 1em;", + conditionalPanel( + condition = sprintf("input['%s'] == 'tmax based imputation'", ns("select_blq_strategy")), + selectizeInput(ns("before_tmax"), "Before tmax", choices = c("drop", "keep"), selected = "keep", options = list(create = TRUE), width = "25%"), + selectizeInput(ns("after_tmax"), "After tmax", choices = c("drop", "keep"), selected = "drop", options = list(create = TRUE), width = "25%") + ), + conditionalPanel( + condition = sprintf("input['%s'] == 'Positional BLQ imputation'", ns("select_blq_strategy")), + selectizeInput(ns("before_first_non_blq"), "Before first non-BLQ", choices = c("drop", "keep"), selected = "drop", options = list(create = TRUE), width = "25%"), + selectizeInput(ns("in_between_non_blqs"), "In between non-BLQs", choices = c("drop", "keep"), selected = "keep", options = list(create = TRUE), width = "25%"), + selectizeInput(ns("after_last_non_blq"), "After last non-BLQ", choices = c("drop", "keep"), selected = "drop", options = list(create = TRUE), width = "25%") + ), + conditionalPanel( + condition = sprintf("input['%s'] == 'Set value for all BLQ'", ns("select_blq_strategy")), + selectizeInput(ns("blq_value"), "BLQ value", choices = c("drop", "keep"), selected = "0.05", options = list(create = TRUE), width = "25%") + ) + ) + ) +} + +data_imputation_server <- function(id) { + moduleServer(id, function(input, output, session) { + ns <- session$ns + + should_impute_c0 <- reactive({ + input$should_impute_c0 + }) + + blq_rule <- reactive({ + req(input$select_blq_strategy) + rule_list <- switch(input$select_blq_strategy, + "tmax based imputation" = list( + before.tmax = input$before_tmax, + after.tmax = input$after_tmax + ), + "Positional BLQ imputation" = list( + first = input$before_first_non_blq, + middle = input$in_between_non_blqs, + last = input$after_last_non_blq + ), + "Set value for all BLQ" = input$blq_value, + NULL + ) + are_valid_inputs <- sapply(rule_list, function(x) grepl('[0-9]*', x) || x %in% c('drop', 'keep')) + if (any(!are_valid_inputs) && !is.null(rule_list[[1]])) { + browser() + showNotification("Please, BLQ imputation values should be numeric or NA.", type = "error") + return(NULL) + } + rule_list + }) + + return(list( + should_impute_c0 = should_impute_c0, + blq_imputation_rule = blq_rule + )) + }) +} diff --git a/inst/shiny/modules/tab_nca/setup/settings.R b/inst/shiny/modules/tab_nca/setup/settings.R index 6e98afa28..22bec6258 100644 --- a/inst/shiny/modules/tab_nca/setup/settings.R +++ b/inst/shiny/modules/tab_nca/setup/settings.R @@ -1,4 +1,3 @@ - #' NCA Settings Server Module #' #' This module handles logic for basic / general settings for the NCA run. Generates appropriate @@ -16,7 +15,7 @@ settings_ui <- function(id) { ns <- NS(id) - + tagList( accordion( accordion_panel( @@ -24,55 +23,55 @@ settings_ui <- function(id) { # Selection of analyte, dose number and specimen fluidRow( column(4, - selectInput( - ns("select_analyte"), - "Choose the Analyte:", - multiple = TRUE, - choices = NULL - ) + selectInput( + ns("select_analyte"), + "Choose the Analyte:", + multiple = TRUE, + choices = NULL + ) ), column(4, - selectInput( - ns("select_profile"), - "Choose the NCA Profile:", - multiple = TRUE, - choices = NULL - ) + selectInput( + ns("select_profile"), + "Choose the NCA Profile:", + multiple = TRUE, + choices = NULL + ) ), column(4, - selectInput( - ns("select_pcspec"), - "Choose the Specimen:", - multiple = TRUE, - choices = NULL - ) + selectInput( + ns("select_pcspec"), + "Choose the Specimen:", + multiple = TRUE, + choices = NULL + ) ) ), # Method, NCA parameters, and units table fluidRow( column(4, - selectInput( - ns("method"), - "Extrapolation Method:", - choices = c("lin-log", "lin up/log down", "linear"), - selected = "lin up/log down" - ) + selectInput( + ns("method"), + "Extrapolation Method:", + choices = c("lin-log", "lin up/log down", "linear"), + selected = "lin up/log down" + ) ), column(4, # pickerinput only enabled when IV and EX data present - shinyjs::hidden( - div( - class = "bioavailability-picker", - pickerInput( - ns("bioavailability"), - "Calculate Bioavailability:", - choices = pknca_cdisc_terms %>% - filter(startsWith(PPTESTCD, "FABS_") | startsWith(PPTESTCD, "FREL_")) %>% - pull(PKNCA, PPTESTCD), - multiple = TRUE, - selected = NULL - ) - ) - ) + shinyjs::hidden( + div( + class = "bioavailability-picker", + pickerInput( + ns("bioavailability"), + "Calculate Bioavailability:", + choices = pknca_cdisc_terms %>% + filter(startsWith(PPTESTCD, "FABS_") | startsWith(PPTESTCD, "FREL_")) %>% + pull(PKNCA, PPTESTCD), + multiple = TRUE, + selected = NULL + ) + ) + ) ) ) ), @@ -89,20 +88,8 @@ settings_ui <- function(id) { ), accordion_panel( title = "Data Imputation", - input_switch( - id = ns("should_impute_c0"), - label = "Impute Concentration", - value = TRUE - ), - br(), - helpText(HTML(paste( - "Imputes a start-of-interval concentration to calculate non-observational parameters:", - "- If DOSNO = 1 & IV bolus: C0 = 0", - "- If DOSNO > 1 & not IV bolus: C0 = predose", - "- If IV bolus & monoexponential data: logslope", - "- If IV bolus & not monoexponential data: C0 = C1", - sep = "
" - ))) + # Moved input_switch for should_impute_c0 into the data_imputation module + data_imputation_ui(ns("data_imputation")) ), accordion_panel( title = "Partial AUCs", @@ -125,36 +112,39 @@ settings_ui <- function(id) { settings_server <- function(id, data, adnca_data, settings_override) { moduleServer(id, function(input, output, session) { ns <- session$ns - + conc_data <- reactive(adnca_data()$conc$data) - + + # Modules for Data Imputation + data_imputation <- data_imputation_server("data_imputation") + # File Upload Handling observeEvent(settings_override(), { settings <- settings_override() - + log_debug_list("User settings override:", settings) - + not_compatible <- c() - + # General # if (all(settings$analyte %in% unique(data()$PARAM))) { updateSelectInput(inputId = "select_analyte", selected = settings$analyte) } else { not_compatible <- append(not_compatible, "Analyte") } - + if (all(settings$profile %in% unique(data()$NCA_PROFILE))) { updateSelectInput(inputId = "select_profile", selected = settings$profile) } else { not_compatible <- append(not_compatible, "NCA Profile") } - + if (all(settings$pcspec %in% unique(data()$PCSPEC))) { updateSelectInput(inputId = "select_pcspec", selected = settings$pcspec) } else { not_compatible <- append(not_compatible, "Dose Specimen") } - + if (length(not_compatible) != 0) { msg <- paste0( paste0(not_compatible, collapse = ", "), @@ -163,31 +153,31 @@ settings_server <- function(id, data, adnca_data, settings_override) { log_warn(msg) showNotification(msg, type = "warning", duration = 10) } - + updateSelectInput(inputId = "method", selected = settings$method) - + if (!is.null(settings$bioavailability)) updateSelectInput(inputId = "bioavailability", selected = settings$bioavailability) - + # Parmeter selection # reset_reactable_memory() - + params_data <- pknca_cdisc_terms %>% filter(TYPE != "PKNCA-not-covered") %>% pull("PKNCA") - + updateReactable( "nca_parameters", selected = which(params_data %in% settings$parameter_selection) ) - + # Data imputation # update_switch("should_impute_c0", value = settings$data_imputation$impute_c0) - + # Partial AUCs # auc_data(settings$partial_aucs) refresh_reactable(refresh_reactable() + 1) - + # Flags # .update_rule_input( session, @@ -195,21 +185,21 @@ settings_server <- function(id, data, adnca_data, settings_override) { settings$flags$adj.r.squared$is.checked, settings$flags$adj.r.squared$threshold ) - + .update_rule_input( session, "aucpext.obs", settings$flags$aucpext.obs$is.checked, settings$flags$aucpext.obs$threshold ) - + .update_rule_input( session, "aucpext.pred", settings$flags$aucpext.pred$is.checked, settings$flags$aucpext.pred$threshold ) - + .update_rule_input( session, "span.ratio", @@ -217,34 +207,34 @@ settings_server <- function(id, data, adnca_data, settings_override) { settings$flags$span.ratio$threshold ) }) - + # Include keyboard limits for the settings GUI display - + # Keyboard limits for the setting thresholds limit_input_value(input, session, "adj.r.squared_threshold", max = 1, min = 0, lab = "RSQADJ") limit_input_value(input, session, "aucpext.obs_threshold", max = 100, min = 0, lab = "AUCPEO") limit_input_value(input, session, "aucpext.pred_threshold", max = 100, min = 0, lab = "AUCPEP") limit_input_value(input, session, "span.ratio_threshold", min = 0, lab = "SPAN") - - + + # Choose dosenumbers to be analyzed observeEvent(data()$DOSNO, priority = -1, { req(data()) - + updateSelectInput( session, inputId = "select_profile", choices = unique(data()$NCA_PROFILE), selected = unique(data()$NCA_PROFILE)[1] ) - + updateSelectInput( session, inputId = "select_analyte", choices = unique(data()$PARAM), selected = unique(data()$PARAM)[1] ) - + updateSelectInput( session, inputId = "select_pcspec", @@ -252,7 +242,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { selected = unique(data()$PCSPEC)[1] ) }) - + DEFAULT_PARAMS <- c( "aucinf.obs", "aucinf.obs.dn", "auclast", "auclast.dn", @@ -266,14 +256,14 @@ settings_server <- function(id, data, adnca_data, settings_override) { "adj.r.squared", "lambda.z.time.first", "aucpext.obs", "aucpext.pred" ) - + output$nca_parameters <- renderReactable({ #remove parameters that are currently unavailable in PKNCA params_data <- pknca_cdisc_terms %>% filter(TYPE != "PKNCA-not-covered") - + default_row_indices <- which(params_data$PKNCA %in% DEFAULT_PARAMS) - + reactable( params_data %>% select(TYPE, PPTESTCD, PPTEST, CAT), @@ -287,22 +277,22 @@ settings_server <- function(id, data, adnca_data, settings_override) { defaultSelected = default_row_indices ) }) - + nca_params <- reactive({ selected_rows <- getReactableState("nca_parameters", "selected") if (is.null(selected_rows) || length(selected_rows) == 0) return(NULL) - + params_data <- pknca_cdisc_terms %>% filter(TYPE != "PKNCA-not-covered") selected_terms <- params_data[selected_rows, , drop = FALSE] - + # Return PKNCA column names selected_terms$PKNCA }) - + output$nca_param_display <- renderUI({ req(nca_params()) - + div( class = "nca-pill-grid", lapply(nca_params(), function(param) { @@ -310,12 +300,12 @@ settings_server <- function(id, data, adnca_data, settings_override) { }) ) }) - + # Reactive value to store the AUC data table auc_data <- reactiveVal( tibble(start_auc = rep(NA_real_, 2), end_auc = rep(NA_real_, 2)) ) - + # Render the editable reactable table refresh_reactable <- reactiveVal(1) output$auc_table <- renderReactable({ @@ -336,7 +326,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { ) }) %>% shiny::bindEvent(refresh_reactable()) - + # Add a blank row on button click observeEvent(input$addRow, { df <- auc_data() @@ -344,7 +334,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { reset_reactable_memory() refresh_reactable(refresh_reactable() + 1) }) - + #' For each of the columns in partial aucs data frame, attach an event that will read #' edits for that column made in the reactable. observe({ @@ -359,7 +349,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { }) }) }) - + settings <- reactive({ req(input$select_analyte) # Wait on general settings UI to be loaded list( @@ -370,7 +360,8 @@ settings_server <- function(id, data, adnca_data, settings_override) { bioavailability = input$bioavailability, parameter_selection = nca_params(), data_imputation = list( - impute_c0 = input$should_impute_c0 + impute_c0 = data_imputation$should_impute_c0(), + blq_imputation_rule = data_imputation$blq_imputation_rule() ), partial_aucs = auc_data(), flags = list( @@ -393,11 +384,11 @@ settings_server <- function(id, data, adnca_data, settings_override) { ) ) }) - + # Debounce the trigger, so the data is not updated too often. settings_debounce <- 2500 settings_debounced <- debounce(settings, settings_debounce) - + # On all changes, disable NCA button for given period of time to prevent the user from running # the NCA before settings are applied. observeEvent(settings(), { @@ -410,7 +401,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { );" )) }) - + settings_debounced }) } @@ -434,12 +425,12 @@ settings_server <- function(id, data, adnca_data, settings_override) { step = step, min = min ) - + # Only include `max` if not NULL if (!is.null(max)) { numeric_args$max <- max } - + fluidRow( column( width = 6, @@ -467,7 +458,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { .update_rule_input <- function(session, id, checked, value) { threshold_id <- paste0(id, "_threshold") rule_id <- paste0(id, "_rule") - + updateCheckboxInput(session = session, inputId = rule_id, value = checked) if (checked) updateNumericInput(session = session, inputId = threshold_id, value = value) From 15b357b457b84849625c331d7b0d4fb37d65cdec Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 25 Jun 2025 18:02:57 +0200 Subject: [PATCH 02/47] fix: make work 'Set value for all BLQ' --- inst/shiny/modules/tab_nca/setup/data_imputation.R | 6 +++++- 1 file changed, 5 insertions(+), 1 deletion(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 7e22d6d69..f2ed20f10 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -69,7 +69,11 @@ data_imputation_server <- function(id) { middle = input$in_between_non_blqs, last = input$after_last_non_blq ), - "Set value for all BLQ" = input$blq_value, + "Set value for all BLQ" = list( + first = input$blq_value, + middle = input$blq_value, + last = input$blq_value + ), NULL ) are_valid_inputs <- sapply(rule_list, function(x) grepl('[0-9]*', x) || x %in% c('drop', 'keep')) From 9884b46f52785b1b1ec96f808f509b0b6ca231c0 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 26 Jun 2025 11:20:30 +0200 Subject: [PATCH 03/47] fix: improve invalid input text handling --- .../modules/tab_nca/setup/data_imputation.R | 24 +++++++++++++++---- 1 file changed, 20 insertions(+), 4 deletions(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index f2ed20f10..20c4c30b0 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -17,6 +17,7 @@ data_imputation_ui <- function(id) { sep = "
" ))), br(), + br(), selectInput( ns("select_blq_strategy"), "Select BLQ Imputation Strategy", @@ -76,12 +77,27 @@ data_imputation_server <- function(id) { ), NULL ) - are_valid_inputs <- sapply(rule_list, function(x) grepl('[0-9]*', x) || x %in% c('drop', 'keep')) - if (any(!are_valid_inputs) && !is.null(rule_list[[1]])) { - browser() - showNotification("Please, BLQ imputation values should be numeric or NA.", type = "error") + # Transform in the list text number to numeric + rule_list <- lapply(rule_list, function(x) { + if (x %in% c("drop", "keep")) { + return(x) + } else if (grepl('^[0-9]+(\\.[0-9]+)?$', x)) { + return(as.numeric(x)) + } else { + return(NA) + } + }) + are_invalid_inputs <- is.na(unlist(rule_list)) + if (any(are_invalid_inputs)) { + showNotification( + "BLQ imputation values must be numeric, 'drop' or 'keep'. + Otherwise, default PKNCA imputation (BLQ position) will be used", + type = "warning", + duration = 8 + ) return(NULL) } + rule_list }) From 8dab1e1e72bfbbac0272039bb319f9b21b1414ef Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 26 Jun 2025 11:21:15 +0200 Subject: [PATCH 04/47] docs: roxygenise --- man/PKNCA_update_data_object.Rd | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/man/PKNCA_update_data_object.Rd b/man/PKNCA_update_data_object.Rd index 2d8a5c566..d71582835 100644 --- a/man/PKNCA_update_data_object.Rd +++ b/man/PKNCA_update_data_object.Rd @@ -12,7 +12,8 @@ PKNCA_update_data_object( selected_profile, selected_pcspec, params, - should_impute_c0 = TRUE + should_impute_c0 = TRUE, + blq_imputation_rule = list(first = "keep", middle = "drop", last = "keep") ) } \arguments{ From 2a7f54af2b6c348b1bbb1f1cafa0bc4b654dd181 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 26 Jun 2025 19:15:43 +0200 Subject: [PATCH 05/47] refactor: create blq_selectize helper fun to elude repetition --- .../modules/tab_nca/setup/data_imputation.R | 70 +++++++++++-------- 1 file changed, 42 insertions(+), 28 deletions(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 20c4c30b0..8f707e14d 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -1,6 +1,6 @@ data_imputation_ui <- function(id) { ns <- NS(id) - + tagList( input_switch( id = ns("should_impute_c0"), @@ -33,18 +33,20 @@ data_imputation_ui <- function(id) { style = "margin-top: 1em;", conditionalPanel( condition = sprintf("input['%s'] == 'tmax based imputation'", ns("select_blq_strategy")), - selectizeInput(ns("before_tmax"), "Before tmax", choices = c("drop", "keep"), selected = "keep", options = list(create = TRUE), width = "25%"), - selectizeInput(ns("after_tmax"), "After tmax", choices = c("drop", "keep"), selected = "drop", options = list(create = TRUE), width = "25%") + blq_selectize(ns("before_tmax"), "Before tmax", selected = "keep"), + blq_selectize(ns("after_tmax"), "After tmax", selected = "drop") ), conditionalPanel( - condition = sprintf("input['%s'] == 'Positional BLQ imputation'", ns("select_blq_strategy")), - selectizeInput(ns("before_first_non_blq"), "Before first non-BLQ", choices = c("drop", "keep"), selected = "drop", options = list(create = TRUE), width = "25%"), - selectizeInput(ns("in_between_non_blqs"), "In between non-BLQs", choices = c("drop", "keep"), selected = "keep", options = list(create = TRUE), width = "25%"), - selectizeInput(ns("after_last_non_blq"), "After last non-BLQ", choices = c("drop", "keep"), selected = "drop", options = list(create = TRUE), width = "25%") + condition = sprintf( + "input['%s'] == 'Positional BLQ imputation'", ns("select_blq_strategy") + ), + blq_selectize(ns("before_first_non_blq"), "Before first non-BLQ", selected = "drop"), + blq_selectize(ns("in_between_non_blqs"), "In between non-BLQs", selected = "keep"), + blq_selectize(ns("after_last_non_blq"), "After last non-BLQ", selected = "drop") ), conditionalPanel( condition = sprintf("input['%s'] == 'Set value for all BLQ'", ns("select_blq_strategy")), - selectizeInput(ns("blq_value"), "BLQ value", choices = c("drop", "keep"), selected = "0.05", options = list(create = TRUE), width = "25%") + blq_selectize(ns("blq_value_first"), "BLQ value (first)", selected = "0.05"), ) ) ) @@ -53,35 +55,36 @@ data_imputation_ui <- function(id) { data_imputation_server <- function(id) { moduleServer(id, function(input, output, session) { ns <- session$ns - + should_impute_c0 <- reactive({ input$should_impute_c0 }) - + blq_rule <- reactive({ req(input$select_blq_strategy) - rule_list <- switch(input$select_blq_strategy, - "tmax based imputation" = list( - before.tmax = input$before_tmax, - after.tmax = input$after_tmax - ), - "Positional BLQ imputation" = list( - first = input$before_first_non_blq, - middle = input$in_between_non_blqs, - last = input$after_last_non_blq - ), - "Set value for all BLQ" = list( - first = input$blq_value, - middle = input$blq_value, - last = input$blq_value - ), - NULL + rule_list <- switch( + input$select_blq_strategy, + "tmax based imputation" = list( + before.tmax = input$before_tmax, + after.tmax = input$after_tmax + ), + "Positional BLQ imputation" = list( + first = input$before_first_non_blq, + middle = input$in_between_non_blqs, + last = input$after_last_non_blq + ), + "Set value for all BLQ" = list( + first = input$blq_value, + middle = input$blq_value, + last = input$blq_value + ), + NULL ) # Transform in the list text number to numeric rule_list <- lapply(rule_list, function(x) { if (x %in% c("drop", "keep")) { return(x) - } else if (grepl('^[0-9]+(\\.[0-9]+)?$', x)) { + } else if (grepl("^[0-9]+(\\.[0-9]+)?$", x)) { return(as.numeric(x)) } else { return(NA) @@ -100,10 +103,21 @@ data_imputation_server <- function(id) { rule_list }) - + return(list( should_impute_c0 = should_impute_c0, blq_imputation_rule = blq_rule )) }) } + +# Helper function for BLQ selectize inputs +blq_selectize <- function(id, label, selected = NULL) { + selectizeInput( + id, label, + choices = c("drop", "keep", selected), + selected = selected, + options = list(create = TRUE), + width = "25%" + ) +} \ No newline at end of file From 5b33ac181eb18b902bfed2b63283d380797379c2 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 26 Jun 2025 19:16:11 +0200 Subject: [PATCH 06/47] refactor: lintr --- inst/shiny/modules/tab_nca.R | 62 +++---- inst/shiny/modules/tab_nca/setup.R | 60 ++++--- inst/shiny/modules/tab_nca/setup/settings.R | 187 ++++++++++---------- 3 files changed, 158 insertions(+), 151 deletions(-) diff --git a/inst/shiny/modules/tab_nca.R b/inst/shiny/modules/tab_nca.R index 00244d841..a27255e50 100644 --- a/inst/shiny/modules/tab_nca.R +++ b/inst/shiny/modules/tab_nca.R @@ -20,7 +20,7 @@ #' @returns `res_nca` reactive with results data object. tab_nca_ui <- function(id) { ns <- NS(id) - + fluidPage( div( class = "d-flex justify-content-between", @@ -58,27 +58,27 @@ tab_nca_ui <- function(id) { tab_nca_server <- function(id, adnca_data, grouping_vars) { moduleServer(id, function(input, output, session) { ns <- session$ns - + #' Setup session-wide object for storing data units. Units can be edited by the user on #' various steps of the workflow (pre- and post-NCA calculation) and the whole application #' should respect the units, regardless of location. session$userData$units_table <- reactiveVal(NULL) - + #' Initializes PKNCA::PKNCAdata object from pre-processed adnca data pknca_data <- reactive({ req(adnca_data()) log_trace("Creating PKNCA::data object.") - + tryCatch({ #' Create data object pknca_object <- PKNCA_create_data_object(adnca_data()) log_success("PKNCA data object created.") - + #' Enable related tabs and update the curent view if data is created succesfully. purrr::walk(c("nca", "visualisation", "tlg"), \(tab) { shinyjs::enable(selector = paste0("#page li a[data-value=", tab, "]")) }) - + pknca_object }, error = function(e) { log_error(e$message) @@ -87,26 +87,26 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { }) }) |> bindEvent(adnca_data()) - + # #' NCA Setup module nca_setup <- setup_server("nca_setup", adnca_data, pknca_data) - + processed_pknca_data <- nca_setup$processed_pknca_data settings <- nca_setup$settings slope_rules <- nca_setup$slope_rules - + output$manual_slopes <- renderTable(slope_rules$manual_slopes()) - + # List all irrelevant warnings to suppres in the NCA calculation irrelevant_regex_warnings <- c( "No intervals for data$", "^Too few points for half-life" ) - + #' Triggers NCA analysis, creating res_nca reactive res_nca <- reactive({ req(processed_pknca_data()) - + withProgress(message = "Calculating NCA...", value = 0, { log_info("Calculating NCA results...") tryCatch({ @@ -114,7 +114,7 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { # from within warning handler without bleeding to global env. pknca_warn_env <- new.env() pknca_warn_env$warnings <- c() - + #' Calculate results res <- withCallingHandlers({ processed_pknca_data() %>% @@ -135,22 +135,22 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { } invokeRestart("muffleWarning") }) - + # Apply flag rules to mark results in the `exclude` column current_rules <- isolate(settings()$flags) flag_rules_to_apply <- current_rules |> purrr::keep(~ .x$is.checked) |> purrr::map(~ .x$threshold) res <- PKNCA_hl_rules_exclusion(res, flag_rules_to_apply) - + # Display unique warnings thrown by PKNCA run. purrr::walk(unique(pknca_warn_env$warnings), \(w) { w_message <- paste0("PKNCA run produced a warning: ", w) log_warn(w_message) showNotification(w_message, type = "warning", duration = 5) }) - - + + #' Apply units if (!is.null(session$userData$units_table())) { res$data$units <- session$userData$units_table() @@ -163,15 +163,15 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { mutate(PPSTRES = PPORRES * conversion_factor) %>% select(-conversion_factor) } - + updateTabsetPanel(session, "ncapanel", selected = "Results") - + log_success("NCA results calculated.") - + # Apply standard CDISC names and return the object res %>% mutate(PPTESTCD = translate_terms(PPTESTCD, "PKNCA", "PPTESTCD")) - + }, error = function(e) { log_error("Error calculating NCA results:\n{conditionMessage(e)}") showNotification(.parse_pknca_error(e), type = "error", duration = NULL) @@ -180,7 +180,7 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { }) }) |> bindEvent(input$nca) - + #' Show slopes results output$slope_results <- DT::renderDataTable({ req(res_nca()) @@ -201,18 +201,18 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { formatStyle("Exclude", target = "row", backgroundColor = styleEqual(NA, NA, default = "#f5b4b4")) }) - + nca_results_server("nca_results", processed_pknca_data, res_nca, settings, grouping_vars) - + #' Descriptive statistics module descriptive_statistics_server("descriptive_stats", res_nca, grouping_vars) - + #' Additional analysis module additional_analysis_server("non_nca", processed_pknca_data, grouping_vars) - + #' Parameter datasets module parameter_datasets_server("parameter_datasets", res_nca) - + # return results for use in other modules res_nca }) @@ -226,7 +226,7 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { #' @returns String with html-formatted error message. .parse_pknca_error <- function(e) { msg <- conditionMessage(e) - + if (grepl("pk.calc.", msg)) { # Handle errors from PKNCA package. param_of_error <- gsub(".*'pk\\.calc\\.(.*)'.*", "\\1", msg) @@ -236,11 +236,11 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { "

", msg, "

If the error is unexpected, please report a bug." ) - + } else if (grepl("^No reason provided", msg)) { # Handle no reason provided erros from the calculation function. msg <- paste(msg, "

Please provide the reason in Setup > Slope Selector tab.") - + } else { # Handle unknown error msg <- paste0( @@ -248,6 +248,6 @@ tab_nca_server <- function(id, adnca_data, grouping_vars) { " please inspect the logs and report a bug." ) } - + HTML(gsub("\\\n", "
", msg)) } diff --git a/inst/shiny/modules/tab_nca/setup.R b/inst/shiny/modules/tab_nca/setup.R index 39c724e1b..5272a23aa 100644 --- a/inst/shiny/modules/tab_nca/setup.R +++ b/inst/shiny/modules/tab_nca/setup.R @@ -16,25 +16,27 @@ setup_ui <- function(id) { ns <- NS(id) - + navset_pill_list( nav_panel( "Settings", fluidRow( - column(6, - fileInput( - ns("settings_upload"), - width = "100%", - label = "Upload settings", - buttonLabel = list(icon("folder"), "Browse"), - accept = ".rds" - ) + column( + 6, + fileInput( + ns("settings_upload"), + width = "100%", + label = "Upload settings", + buttonLabel = list(icon("folder"), "Browse"), + accept = ".rds" + ) ), - column(6, - downloadButton( - ns("settings_download"), - label = "Download settings" - ) + column( + 6, + downloadButton( + ns("settings_download"), + label = "Download settings" + ) ) ), fluidRow(units_table_ui(ns("units_table"))), @@ -49,13 +51,13 @@ setup_server <- function(id, data, adnca_data) { moduleServer(id, function(input, output, session) { # Gather all settings from the appropriate module settings <- settings_server("nca_settings", data, adnca_data, settings_override) - + # Create processed data object with applied settings. - + processed_pknca_data <- reactive({ req(adnca_data(), settings()) log_trace("Updating PKNCA::data object.") - + processed_pknca_data <- PKNCA_update_data_object( adnca_data = adnca_data(), auc_data = settings()$partial_aucs, @@ -67,14 +69,14 @@ setup_server <- function(id, data, adnca_data) { should_impute_c0 = settings()$data_imputation$impute_c0, blq_imputation_rule = settings()$data_imputation$blq_imputation_rule ) - + # Show bioavailability widget if it is possible to calculate if (processed_pknca_data$dose$data$std_route %>% unique() %>% length() == 2) { shinyjs::show(selector = ".bioavailability-picker") } else { shinyjs::hide(selector = ".bioavailability-picker") } - + if (nrow(processed_pknca_data$intervals) == 0) { showNotification( "All intervals were filtered. Please revise your settings", @@ -82,13 +84,13 @@ setup_server <- function(id, data, adnca_data) { duration = 10 ) } - + processed_pknca_data }) - + # Parameter unit changes option: Opens a modal message with a units table to edit units_table_server("units_table", processed_pknca_data) - + # Create version for slope plots # Only parameters required for the slope plots are set in intervals # NCA dynamic changes/filters based on user selections @@ -96,7 +98,7 @@ setup_server <- function(id, data, adnca_data) { req(adnca_data(), settings(), settings()$profile, settings()$analyte, settings()$pcspec, settings()$data_imputation$blq_imputation_rule) log_trace("Updating PKNCA::data object for slopes.") - + PKNCA_update_data_object( adnca_data = adnca_data(), auc_data = settings()$partial_aucs, @@ -110,15 +112,15 @@ setup_server <- function(id, data, adnca_data) { blq_imputation_rule = settings()$data_imputation$blq_imputation_rule ) }) - + slope_rules <- slope_selector_server( "slope_selector", slopes_pknca_data, manual_slopes_override ) - + summary_server("nca_setup_summary", processed_pknca_data) - + # Handle downloading and uploading settings output$settings_download <- downloadHandler( filename = paste0("aNCA_settings_", Sys.Date(), ".rds"), @@ -126,15 +128,15 @@ setup_server <- function(id, data, adnca_data) { saveRDS(list(settings = settings(), slope_rules = slope_rules$manual_slopes()), con) } ) - + imported_settings <- reactive({ req(input$settings_upload) readRDS(input$settings_upload$datapath) }) - + settings_override <- reactive(imported_settings()$settings) manual_slopes_override <- reactive(imported_settings()$slope_rules) - + list( processed_pknca_data = processed_pknca_data, settings = settings, diff --git a/inst/shiny/modules/tab_nca/setup/settings.R b/inst/shiny/modules/tab_nca/setup/settings.R index 22bec6258..22eca2750 100644 --- a/inst/shiny/modules/tab_nca/setup/settings.R +++ b/inst/shiny/modules/tab_nca/setup/settings.R @@ -15,63 +15,68 @@ settings_ui <- function(id) { ns <- NS(id) - + tagList( accordion( accordion_panel( title = "General Settings", # Selection of analyte, dose number and specimen fluidRow( - column(4, - selectInput( - ns("select_analyte"), - "Choose the Analyte:", - multiple = TRUE, - choices = NULL - ) + column( + 4, + selectInput( + ns("select_analyte"), + "Choose the Analyte:", + multiple = TRUE, + choices = NULL + ) ), - column(4, - selectInput( - ns("select_profile"), - "Choose the NCA Profile:", - multiple = TRUE, - choices = NULL - ) + column( + 4, + selectInput( + ns("select_profile"), + "Choose the NCA Profile:", + multiple = TRUE, + choices = NULL + ) ), - column(4, - selectInput( - ns("select_pcspec"), - "Choose the Specimen:", - multiple = TRUE, - choices = NULL - ) + column( + 4, + selectInput( + ns("select_pcspec"), + "Choose the Specimen:", + multiple = TRUE, + choices = NULL + ) ) ), # Method, NCA parameters, and units table fluidRow( - column(4, - selectInput( - ns("method"), - "Extrapolation Method:", - choices = c("lin-log", "lin up/log down", "linear"), - selected = "lin up/log down" - ) + column( + 4, + selectInput( + ns("method"), + "Extrapolation Method:", + choices = c("lin-log", "lin up/log down", "linear"), + selected = "lin up/log down" + ) ), - column(4, # pickerinput only enabled when IV and EX data present - shinyjs::hidden( - div( - class = "bioavailability-picker", - pickerInput( - ns("bioavailability"), - "Calculate Bioavailability:", - choices = pknca_cdisc_terms %>% - filter(startsWith(PPTESTCD, "FABS_") | startsWith(PPTESTCD, "FREL_")) %>% - pull(PKNCA, PPTESTCD), - multiple = TRUE, - selected = NULL - ) - ) - ) + column( + 4, # pickerinput only enabled when IV and EX data present + shinyjs::hidden( + div( + class = "bioavailability-picker", + pickerInput( + ns("bioavailability"), + "Calculate Bioavailability:", + choices = pknca_cdisc_terms %>% + filter(startsWith(PPTESTCD, "FABS_") | startsWith(PPTESTCD, "FREL_")) %>% + pull(PKNCA, PPTESTCD), + multiple = TRUE, + selected = NULL + ) + ) + ) ) ) ), @@ -112,39 +117,39 @@ settings_ui <- function(id) { settings_server <- function(id, data, adnca_data, settings_override) { moduleServer(id, function(input, output, session) { ns <- session$ns - + conc_data <- reactive(adnca_data()$conc$data) - + # Modules for Data Imputation data_imputation <- data_imputation_server("data_imputation") - + # File Upload Handling observeEvent(settings_override(), { settings <- settings_override() - + log_debug_list("User settings override:", settings) - + not_compatible <- c() - + # General # if (all(settings$analyte %in% unique(data()$PARAM))) { updateSelectInput(inputId = "select_analyte", selected = settings$analyte) } else { not_compatible <- append(not_compatible, "Analyte") } - + if (all(settings$profile %in% unique(data()$NCA_PROFILE))) { updateSelectInput(inputId = "select_profile", selected = settings$profile) } else { not_compatible <- append(not_compatible, "NCA Profile") } - + if (all(settings$pcspec %in% unique(data()$PCSPEC))) { updateSelectInput(inputId = "select_pcspec", selected = settings$pcspec) } else { not_compatible <- append(not_compatible, "Dose Specimen") } - + if (length(not_compatible) != 0) { msg <- paste0( paste0(not_compatible, collapse = ", "), @@ -153,31 +158,31 @@ settings_server <- function(id, data, adnca_data, settings_override) { log_warn(msg) showNotification(msg, type = "warning", duration = 10) } - + updateSelectInput(inputId = "method", selected = settings$method) - + if (!is.null(settings$bioavailability)) updateSelectInput(inputId = "bioavailability", selected = settings$bioavailability) - + # Parmeter selection # reset_reactable_memory() - + params_data <- pknca_cdisc_terms %>% filter(TYPE != "PKNCA-not-covered") %>% pull("PKNCA") - + updateReactable( "nca_parameters", selected = which(params_data %in% settings$parameter_selection) ) - + # Data imputation # update_switch("should_impute_c0", value = settings$data_imputation$impute_c0) - + # Partial AUCs # auc_data(settings$partial_aucs) refresh_reactable(refresh_reactable() + 1) - + # Flags # .update_rule_input( session, @@ -185,21 +190,21 @@ settings_server <- function(id, data, adnca_data, settings_override) { settings$flags$adj.r.squared$is.checked, settings$flags$adj.r.squared$threshold ) - + .update_rule_input( session, "aucpext.obs", settings$flags$aucpext.obs$is.checked, settings$flags$aucpext.obs$threshold ) - + .update_rule_input( session, "aucpext.pred", settings$flags$aucpext.pred$is.checked, settings$flags$aucpext.pred$threshold ) - + .update_rule_input( session, "span.ratio", @@ -207,34 +212,34 @@ settings_server <- function(id, data, adnca_data, settings_override) { settings$flags$span.ratio$threshold ) }) - + # Include keyboard limits for the settings GUI display - + # Keyboard limits for the setting thresholds limit_input_value(input, session, "adj.r.squared_threshold", max = 1, min = 0, lab = "RSQADJ") limit_input_value(input, session, "aucpext.obs_threshold", max = 100, min = 0, lab = "AUCPEO") limit_input_value(input, session, "aucpext.pred_threshold", max = 100, min = 0, lab = "AUCPEP") limit_input_value(input, session, "span.ratio_threshold", min = 0, lab = "SPAN") - - + + # Choose dosenumbers to be analyzed observeEvent(data()$DOSNO, priority = -1, { req(data()) - + updateSelectInput( session, inputId = "select_profile", choices = unique(data()$NCA_PROFILE), selected = unique(data()$NCA_PROFILE)[1] ) - + updateSelectInput( session, inputId = "select_analyte", choices = unique(data()$PARAM), selected = unique(data()$PARAM)[1] ) - + updateSelectInput( session, inputId = "select_pcspec", @@ -242,7 +247,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { selected = unique(data()$PCSPEC)[1] ) }) - + DEFAULT_PARAMS <- c( "aucinf.obs", "aucinf.obs.dn", "auclast", "auclast.dn", @@ -256,14 +261,14 @@ settings_server <- function(id, data, adnca_data, settings_override) { "adj.r.squared", "lambda.z.time.first", "aucpext.obs", "aucpext.pred" ) - + output$nca_parameters <- renderReactable({ #remove parameters that are currently unavailable in PKNCA params_data <- pknca_cdisc_terms %>% filter(TYPE != "PKNCA-not-covered") - + default_row_indices <- which(params_data$PKNCA %in% DEFAULT_PARAMS) - + reactable( params_data %>% select(TYPE, PPTESTCD, PPTEST, CAT), @@ -277,22 +282,22 @@ settings_server <- function(id, data, adnca_data, settings_override) { defaultSelected = default_row_indices ) }) - + nca_params <- reactive({ selected_rows <- getReactableState("nca_parameters", "selected") if (is.null(selected_rows) || length(selected_rows) == 0) return(NULL) - + params_data <- pknca_cdisc_terms %>% filter(TYPE != "PKNCA-not-covered") selected_terms <- params_data[selected_rows, , drop = FALSE] - + # Return PKNCA column names selected_terms$PKNCA }) - + output$nca_param_display <- renderUI({ req(nca_params()) - + div( class = "nca-pill-grid", lapply(nca_params(), function(param) { @@ -300,12 +305,12 @@ settings_server <- function(id, data, adnca_data, settings_override) { }) ) }) - + # Reactive value to store the AUC data table auc_data <- reactiveVal( tibble(start_auc = rep(NA_real_, 2), end_auc = rep(NA_real_, 2)) ) - + # Render the editable reactable table refresh_reactable <- reactiveVal(1) output$auc_table <- renderReactable({ @@ -326,7 +331,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { ) }) %>% shiny::bindEvent(refresh_reactable()) - + # Add a blank row on button click observeEvent(input$addRow, { df <- auc_data() @@ -334,7 +339,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { reset_reactable_memory() refresh_reactable(refresh_reactable() + 1) }) - + #' For each of the columns in partial aucs data frame, attach an event that will read #' edits for that column made in the reactable. observe({ @@ -349,7 +354,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { }) }) }) - + settings <- reactive({ req(input$select_analyte) # Wait on general settings UI to be loaded list( @@ -384,11 +389,11 @@ settings_server <- function(id, data, adnca_data, settings_override) { ) ) }) - + # Debounce the trigger, so the data is not updated too often. settings_debounce <- 2500 settings_debounced <- debounce(settings, settings_debounce) - + # On all changes, disable NCA button for given period of time to prevent the user from running # the NCA before settings are applied. observeEvent(settings(), { @@ -401,7 +406,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { );" )) }) - + settings_debounced }) } @@ -425,12 +430,12 @@ settings_server <- function(id, data, adnca_data, settings_override) { step = step, min = min ) - + # Only include `max` if not NULL if (!is.null(max)) { numeric_args$max <- max } - + fluidRow( column( width = 6, @@ -458,7 +463,7 @@ settings_server <- function(id, data, adnca_data, settings_override) { .update_rule_input <- function(session, id, checked, value) { threshold_id <- paste0(id, "_threshold") rule_id <- paste0(id, "_rule") - + updateCheckboxInput(session = session, inputId = rule_id, value = checked) if (checked) updateNumericInput(session = session, inputId = threshold_id, value = value) From 61b87d0f1e4d5814b50f67d7b96fdb1a2c8c87a5 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 26 Jun 2025 19:16:40 +0200 Subject: [PATCH 07/47] docs: roxygenise --- R/PKNCA.R | 9 +++++++-- man/PKNCA_update_data_object.Rd | 6 ++++++ 2 files changed, 13 insertions(+), 2 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index e9a9784be..47d31a124 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -176,6 +176,11 @@ PKNCA_create_data_object <- function(adnca_data) { # nolint: object_name_linter #' @param selected_pcspec User selected specimen #' @param params A list of parameters for NCA calculation #' @param should_impute_c0 Logical indicating if start values should be imputed +#' @param blq_imputation_rule A list defining the BLQ imputation rule using PKNCA format. +#' The list should either contain three elements named: `first`, `middle`, and `last` or +#' two elements named `before.tmax` and `after.tmax`. Each element can be a numeric value +#' (substituting the BLQ value), or a string such as `"drop"` (ignores the value) +#' or `"keep"` (keeps the value as 0). #' #' @returns A fully configured `PKNCAdata` object. #' @@ -254,7 +259,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter # Impute start values if requested if (should_impute_c0) { data <- create_start_impute(data) - + # Don't impute parameters that are not AUC dependent params_auc_dep <- pknca_cdisc_terms %>% filter(grepl("auc|aumc", PKNCA) | grepl("auc", Depends)) %>% @@ -265,7 +270,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% pull(PKNCA) |> intersect(names(PKNCA::get.interval.cols())) - + all_impute_methods <- na.omit(unique(data$intervals$impute)) data$intervals <- Reduce(function(d, ti_arg) { diff --git a/man/PKNCA_update_data_object.Rd b/man/PKNCA_update_data_object.Rd index d71582835..356955e14 100644 --- a/man/PKNCA_update_data_object.Rd +++ b/man/PKNCA_update_data_object.Rd @@ -32,6 +32,12 @@ PKNCA_update_data_object( \item{params}{A list of parameters for NCA calculation} \item{should_impute_c0}{Logical indicating if start values should be imputed} + +\item{blq_imputation_rule}{A list defining the BLQ imputation rule using PKNCA format. +The list should either contain three elements named: \code{first}, \code{middle}, and \code{last} or +two elements named \code{before.tmax} and \code{after.tmax}. Each element can be a numeric value +(substituting the BLQ value), or a string such as \code{"drop"} (ignores the value) +or \code{"keep"} (keeps the value as 0).} } \value{ A fully configured \code{PKNCAdata} object. From a643f94c714614ea8ff7488871ee0f5a515c37b2 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 27 Jun 2025 08:51:00 +0200 Subject: [PATCH 08/47] fix: default before_tmax should be 0 --- inst/shiny/modules/tab_nca/setup/data_imputation.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 8f707e14d..e53daf964 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -33,7 +33,7 @@ data_imputation_ui <- function(id) { style = "margin-top: 1em;", conditionalPanel( condition = sprintf("input['%s'] == 'tmax based imputation'", ns("select_blq_strategy")), - blq_selectize(ns("before_tmax"), "Before tmax", selected = "keep"), + blq_selectize(ns("before_tmax"), "Before tmax", selected = "0"), blq_selectize(ns("after_tmax"), "After tmax", selected = "drop") ), conditionalPanel( From 39356c1a50b7999ee01d75f6047cbf4dde792d30 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 27 Jun 2025 09:19:55 +0200 Subject: [PATCH 09/47] fix: problem in blq_selectize definition for BLQ value --- R/PKNCA.R | 1 + inst/shiny/modules/tab_nca/setup/data_imputation.R | 5 +++-- 2 files changed, 4 insertions(+), 2 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index 47d31a124..90fadf51c 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -144,6 +144,7 @@ PKNCA_create_data_object <- function(adnca_data) { # nolint: object_name_linter intervals = intervals, #TODO: should be default units = PKNCA_build_units_table(pknca_conc, pknca_dose) ) + pknca_data_object } diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index e53daf964..5c1bb5abc 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -46,7 +46,7 @@ data_imputation_ui <- function(id) { ), conditionalPanel( condition = sprintf("input['%s'] == 'Set value for all BLQ'", ns("select_blq_strategy")), - blq_selectize(ns("blq_value_first"), "BLQ value (first)", selected = "0.05"), + blq_selectize(ns("blq_value"), "Value for BLQ", selected = "0.05"), ) ) ) @@ -80,6 +80,7 @@ data_imputation_server <- function(id) { ), NULL ) + # Transform in the list text number to numeric rule_list <- lapply(rule_list, function(x) { if (x %in% c("drop", "keep")) { @@ -115,7 +116,7 @@ data_imputation_server <- function(id) { blq_selectize <- function(id, label, selected = NULL) { selectizeInput( id, label, - choices = c("drop", "keep", selected), + choices = unique(c("drop", "keep", selected)), selected = selected, options = list(create = TRUE), width = "25%" From f6b2c8a4bc983a21bc623d7ddf1e3455fb9fcd36 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 27 Jun 2025 09:56:24 +0200 Subject: [PATCH 10/47] data: AVAL < 0.05 was changed to 0 (BLQ) --- inst/shiny/data/Dummy_complex_data.csv | 302 ++++++++++++------------- 1 file changed, 151 insertions(+), 151 deletions(-) diff --git a/inst/shiny/data/Dummy_complex_data.csv b/inst/shiny/data/Dummy_complex_data.csv index 9c3b747d9..d75fd9beb 100644 --- a/inst/shiny/data/Dummy_complex_data.csv +++ b/inst/shiny/data/Dummy_complex_data.csv @@ -5,22 +5,22 @@ "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,7.5,7.5,8,8,8.66,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",8.66,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.49,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,27.25,27.25,48,48,7.03,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",7.03,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.48,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,73.08,73.08,144,144,3.78,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.78,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.0063,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,2425.17,2425.17,NA,NA,0,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Safety Follow Up",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",2,503.67,-0.33,0,504,0,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.53,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,7.28,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",7.28,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,533,29,48,552,6.25,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",6.25,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.955,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.955,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,695.92,191.92,384,888,0.68,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.68,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.54,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0031,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,7.99,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",7.99,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.04,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1182.58,174.58,336,1344,1.28,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",1.28,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.06,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1345.83,337.83,672,1680,0.116,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.116,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.07,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0.0201,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1513.5,1.5,0.5,1512.5,8.73,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",8.73,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1683.17,171.17,336,1848,1.11,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",1.11,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.5,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1849,337,672,2184,0.149,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",0.149,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.0258,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2017.5,1.5,0.5,2016.5,6.84,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",6.84,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.48,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2184.08,168.08,336,2352,1.07,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 8",1.07,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.45,"Sponsor123",11101 "XX01","XX01-11102","Analyte01","SERUM","EVERY WEEK",1,170.25,1.75,0,168.5,14.9,"Analyte01","intravascular",35,74,"F","WHITE",1.55,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",14.9,"ug/mL",0,"18/08/2021 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","11/08/2021 15:53",163,54.9,"kg","cm",1.56,"Sponsor123",11102 @@ -105,7 +105,7 @@ "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",2,172.632,4.632,4,172,14.7,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",14.7,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.07,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",2,192.302,24.302,48,216,9.06,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",9.06,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.99,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",2,242.052,74.052,192,360,4.24,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",4.24,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.97,"Sponsor123",11107 -"XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0058,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 +"XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,505.862,1.862,0.5,504.5,23,"Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",23,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.56,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,531.452,27.452,48,552,7.62,"Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",7.62,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",4,672.612,0.612,0,672,0.6,"Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.6,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 @@ -144,22 +144,22 @@ "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",1,9.782,9.782,8,8,4.45,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.45,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",1,24.652,24.652,48,48,2.61,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.61,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.59,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",1,74.752,74.752,144,144,0.703,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0.703,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.55,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.024,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,169.612,1.612,0.5,168.5,7.83,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.83,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.12,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,172.582,4.582,4,172,6.47,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",6.47,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.19,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,193.582,25.582,48,216,3.47,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",3.47,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.11,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,265.512,97.512,192,360,0.102,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.102,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.14,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0105,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,337.532,1.532,0.5,336.5,9.79,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",9.79,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.65,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,361.712,25.712,48,384,3.89,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",3.89,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.62,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0111,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,505.582,1.582,0.5,504.5,7.5,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",7.5,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.49,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,529.062,25.062,48,552,2.2,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.2,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.47,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.0268,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,673.682,1.682,0.5,672.5,8.87,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",8.87,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.54,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,699.452,27.452,48,720,3.57,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",3.57,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,768.332,96.332,192,864,0.325,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.325,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.64,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.0378,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",6,841.652,1.652,0.5,840.5,7.19,"Analyte01","intravascular",35,61,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",7.19,"ug/mL",0,"28/02/2022 18:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","04/04/2022 14:03",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11110","Analyte01","SERUM","EVERY WEEK",1,-0.846,-0.846,0,0,0,"Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/06/2022 15:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.54,"Sponsor123",11110 "XX01","XX01-11110","Analyte01","SERUM","EVERY WEEK",1,1.604,1.604,0.5,0.5,8.83,"Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",8.83,"ug/mL",0,"06/07/2022 11:18",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.49,"Sponsor123",11110 @@ -227,7 +227,7 @@ "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",2,172.72,4.72,4,172,10.5,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",10.5,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.41,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",2,191.67,23.67,48,216,8.15,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",8.15,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",2,237.08,69.08,192,360,2.09,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",2.09,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.49,"Sponsor123",11112 -"XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0441,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 +"XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",3,337.72,1.72,0.5,336.5,9.21,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",9.21,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.45,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",4,504.3,0.3,0,504,0.108,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.108,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.5,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY 3 WEEKS",4,505.53,1.53,0.5,504.5,9.45,"Analyte01","intravascular",35,42,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",9.45,"ug/mL",0,"23/08/2022 11:13",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/08/2022 11:28",177,92.2,"kg","cm",0.97,"Sponsor123",11112 @@ -246,7 +246,7 @@ "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",2,172.5,4.5,4,172,10.7,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",10.7,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.02,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",2,192.83,24.83,48,216,8.7,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",8.7,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.04,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",2,263.67,95.67,192,360,2.52,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",2.52,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.01,"Sponsor123",11201 -"XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.002,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 +"XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,505.5,1.5,0.5,504.5,11.8,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",11.8,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.52,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,531.08,27.08,48,552,7.95,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",7.95,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",4,672.75,0.75,0,672,0.793,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.793,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 @@ -255,7 +255,7 @@ "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",4,772.75,100.75,192,864,2.7,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",2.7,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.48,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",5,840.67,0.67,0,840,0.898,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.898,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.5,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY 3 WEEKS",5,841.5,1.5,0.5,840.5,15.2,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",15.2,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.56,"Sponsor123",11201 -"XX01","XX01-11201","Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.0097,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 +"XX01","XX01-11201","Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,-1.663333333,-1.663333333,0,0,0,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"31/05/2022 13:36",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.49,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,1.716666667,1.716666667,0.5,0.5,9.38,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",9.38,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,5.446666667,5.446666667,4,4,8.99,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",8.99,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 @@ -264,17 +264,17 @@ "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,78.36666667,78.36666667,144,144,2.11,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.11,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,167.6866667,167.6866667,336,336,0.188,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.188,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,194.0866667,194.0866667,216,216,0.0788,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.0788,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.44,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.011,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.003,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,502.3866667,-1.613333333,0,504,0,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,505.8166667,1.816666667,0.5,504.5,8.42,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",8.42,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.56,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,670.4966667,166.4966667,336,840,0.154,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.154,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.55,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,693.2166667,189.2166667,384,888,0.0795,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.0795,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.0231,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1007.416667,-0.583333333,0,1008,0,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.59,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1009.536667,1.536666667,0.5,1008.5,9.17,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",9.17,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.97,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1174.966667,166.9666667,336,1344,0.126,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.126,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.98,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.0031,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 "XX01","XX01-11203","Analyte01","SERUM","EVERY WEEK",1,-1.086,-1.086,0,0,0,"Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"02/06/2022 12:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.6,"Sponsor123",11203 "XX01","XX01-11203","Analyte01","SERUM","EVERY WEEK",1,1.664,1.664,0.5,0.5,12.6,"Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",12.6,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.57,"Sponsor123",11203 "XX01","XX01-11203","Analyte01","SERUM","EVERY WEEK",1,6.084,6.084,4,4,14,"Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",14,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.59,"Sponsor123",11203 @@ -316,7 +316,7 @@ "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",1,9.662,9.662,8,8,19.9,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",19.9,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.57,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",1,27.002,27.002,48,48,11.1,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",11.1,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.61,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",1,72.752,72.752,144,144,6.14,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",6.14,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.55,"Sponsor123",11204 -"XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0166,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 +"XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,506.662,2.662,0.5,504.5,13,"Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",13,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.26,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,530.502,26.502,48,552,13.4,"Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",13.4,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",3,671.712,-0.288,0,672,2.5,"Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.5,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 @@ -371,19 +371,19 @@ "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",1,75.49857143,75.49857143,144,144,6.61,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",6.61,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.72,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",1,170.7485714,170.7485714,336,336,2.59,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",2.59,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.74,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",1,338.0885714,338.0885714,672,672,0.349,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.349,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.67,"Sponsor123",25101 -"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0185,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 +"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,506.1885714,2.188571429,0.5,504.5,11.7,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",11.7,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.14,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,531.8885714,27.88857143,48,552,9,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",9,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.13,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,668.7185714,164.7185714,336,840,1.97,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.97,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,699.7185714,195.7185714,384,888,1.43,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",1.43,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,767.7185714,263.7185714,528,1032,0.69,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.69,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.23,"Sponsor123",25101 -"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0211,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 +"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1010.048571,2.048571429,0.5,1008.5,13.3,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",13.3,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.63,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1177.548571,169.5485714,336,1344,2.05,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",2.05,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.54,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1345.298571,337.2985714,672,1680,0.32,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.32,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.58,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",4,1514.248571,1.748571429,0,1512.5,12.7,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",12.7,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.64,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",4,1681.088571,168.5885714,335.5,1848,2.29,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",2.29,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.6,"Sponsor123",25101 -"XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.04,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 +"XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",6,2017.968571,1.468571429,0,2016.5,8.69,"Analyte01","intravascular",35,70,"F","WHITE",0.32,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",8.69,"ug/mL",0,"13/09/2022 12:34",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","23/08/2022 11:35",149,64,"kg","cm",0.31,"Sponsor123",25101 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,-0.42,-0.42,0,0,0,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"16/06/2022 11:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.56,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,1.5,1.5,0.5,0.5,12.1,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",12.1,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.47,"Sponsor123",25102 @@ -393,13 +393,13 @@ "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.61,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.61,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.44,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,167.92,167.92,336,336,1.45,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.45,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.5,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.968,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.968,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 -"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0315,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 -"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0034,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 +"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 +"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,5.25,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.25,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1.05,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,530.67,26.67,48,552,7.65,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",7.65,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,671.83,167.83,336,840,1.88,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.88,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.96,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,698.65,194.65,384,888,1.42,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",1.42,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.97,"Sponsor123",25102 -"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0069,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 +"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,10.2,"Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",10.2,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.54,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1176.22,168.22,336,1344,2,"Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",2,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.45,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1344.22,336.22,672,1680,0.147,"Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.147,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.52,"Sponsor123",25102 @@ -410,7 +410,7 @@ "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,25.08,25.08,48,48,6.32,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.32,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.48,"Sponsor123",25103 "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.12,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.12,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.46,"Sponsor123",25103 "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,170.82,170.82,336,336,0.603,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.603,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.5,"Sponsor123",25103 -"XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0027,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 +"XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,503.95,503.95,NA,NA,0,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,-2.994285714,-2.994285714,0,0,0,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"19/07/2022 12:37",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,1.765714286,1.765714286,0.5,0.5,14.4,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",14.4,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.49,"Sponsor123",25104 @@ -419,8 +419,8 @@ "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,27.60571429,27.60571429,48,48,8.16,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",8.16,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.54,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,71.60571429,71.60571429,144,144,4.51,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",4.51,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,1.28,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.28,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 -"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0187,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 -"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.002,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 +"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 +"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,505.6557143,1.655714286,0.5,504.5,12.1,"Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",12.1,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,527.8157143,23.81571429,48,552,9.64,"Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",9.64,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.51,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,677.0157143,173.0157143,336,840,1.65,"Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.65,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 @@ -438,22 +438,22 @@ "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,7.5,7.5,8,8,8.66,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.33,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.49,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,27.25,27.25,48,48,7.03,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.515,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.48,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.08,73.08,144,144,3.78,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.89,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.00315,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,2425.17,2425.17,NA,NA,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Safety Follow Up",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",2,503.67,-0.33,0,504,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.53,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,7.28,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.64,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,533,29,48,552,6.25,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.125,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.955,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.4775,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,695.92,191.92,384,888,0.68,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.34,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.54,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.00155,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,7.99,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",3.995,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.04,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1182.58,174.58,336,1344,1.28,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.64,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.06,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1345.83,337.83,672,1680,0.116,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.058,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.07,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0.01005,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1513.5,1.5,0.5,1512.5,8.73,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",4.365,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1683.17,171.17,336,1848,1.11,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",0.555,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.5,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1849,337,672,2184,0.149,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",0.0745,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.0129,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2017.5,1.5,0.5,2016.5,6.84,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",3.42,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.48,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2184.08,168.08,336,2352,1.07,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 8",0.535,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.45,"Sponsor123",11101 "XX01","XX01-11102","Metab. of Analyte01","SERUM","EVERY WEEK",1,170.25,1.75,0,168.5,14.9,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",1.55,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.45,"ug/mL",0,"18/08/2021 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","11/08/2021 15:53",163,54.9,"kg","cm",1.56,"Sponsor123",11102 @@ -515,7 +515,7 @@ "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",9,1345.58,1.58,0.5,1344.5,3.61,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",1.805,"ug/mL",0,"18/11/2021 11:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/11/2021 13:15",168,102.6,"kg","cm",0.54,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",10,1511.75,-0.25,0,1512,0.271,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0.1355,"ug/mL",0,"18/11/2021 11:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/11/2021 13:15",168,102.6,"kg","cm",0.54,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",10,1513.53,1.53,0.5,1512.5,4.6,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",2.3,"ug/mL",0,"29/11/2021 13:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","18/11/2021 11:50",168,102.6,"kg","cm",0.61,"Sponsor123",11103 -"XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",11,1680.08,0.08,0,1680,0.0917,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",0.04585,"ug/mL",0,"29/11/2021 13:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","18/11/2021 11:50",168,102.6,"kg","cm",0.57,"Sponsor123",11103 +"XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",11,1680.08,0.08,0,1680,0.0917,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",0,"ug/mL",0,"29/11/2021 13:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","18/11/2021 11:50",168,102.6,"kg","cm",0.57,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",11,1681.58,1.58,0.5,1680.5,4.52,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",2.26,"ug/mL",0,"07/12/2021 13:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 13:20",168,102.6,"kg","cm",0.58,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",12,1848.67,0.67,0,1848,0.4,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",0.2,"ug/mL",0,"07/12/2021 13:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 13:20",168,102.6,"kg","cm",0.53,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",12,1849.67,1.67,0.5,1848.5,6.72,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",3.36,"ug/mL",0,"14/12/2021 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/12/2021 13:30",168,102.6,"kg","cm",0.59,"Sponsor123",11103 @@ -538,7 +538,7 @@ "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.632,4.632,4,172,14.7,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.35,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.07,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",2,192.302,24.302,48,216,9.06,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",4.53,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.99,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",2,242.052,74.052,192,360,4.24,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",2.12,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.97,"Sponsor123",11107 -"XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0029,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 +"XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,505.862,1.862,0.5,504.5,23,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",11.5,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.56,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,531.452,27.452,48,552,7.62,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.81,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",4,672.612,0.612,0,672,0.6,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.3,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 @@ -577,22 +577,22 @@ "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.782,9.782,8,8,4.45,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",2.225,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",1,24.652,24.652,48,48,2.61,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",1.305,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.59,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",1,74.752,74.752,144,144,0.703,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0.3515,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.55,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.012,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,169.612,1.612,0.5,168.5,7.83,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",3.915,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.12,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.582,4.582,4,172,6.47,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",3.235,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.19,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,193.582,25.582,48,216,3.47,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.735,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.11,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,265.512,97.512,192,360,0.102,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.051,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.14,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.00525,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,337.532,1.532,0.5,336.5,9.79,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",4.895,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.65,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,361.712,25.712,48,384,3.89,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",1.945,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.62,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.00555,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,505.582,1.582,0.5,504.5,7.5,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.75,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.49,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,529.062,25.062,48,552,2.2,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.1,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.47,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.0134,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,673.682,1.682,0.5,672.5,8.87,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",4.435,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.54,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,699.452,27.452,48,720,3.57,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",1.785,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,768.332,96.332,192,864,0.325,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.1625,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.64,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.0189,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",6,841.652,1.652,0.5,840.5,7.19,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.595,"ug/mL",0,"28/02/2022 18:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","04/04/2022 14:03",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11110","Metab. of Analyte01","SERUM","EVERY WEEK",1,-0.846,-0.846,0,0,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/06/2022 15:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.54,"Sponsor123",11110 "XX01","XX01-11110","Metab. of Analyte01","SERUM","EVERY WEEK",1,1.604,1.604,0.5,0.5,8.83,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.415,"ug/mL",0,"06/07/2022 11:18",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.49,"Sponsor123",11110 @@ -660,7 +660,7 @@ "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.72,4.72,4,172,10.5,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",5.25,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.41,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",2,191.67,23.67,48,216,8.15,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",4.075,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",2,237.08,69.08,192,360,2.09,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.045,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.49,"Sponsor123",11112 -"XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.02205,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 +"XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",3,337.72,1.72,0.5,336.5,9.21,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",4.605,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.45,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",4,504.3,0.3,0,504,0.108,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.054,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.5,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,505.53,1.53,0.5,504.5,9.45,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",4.725,"ug/mL",0,"23/08/2022 11:13",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/08/2022 11:28",177,92.2,"kg","cm",0.97,"Sponsor123",11112 @@ -679,7 +679,7 @@ "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.5,4.5,4,172,10.7,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",5.35,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.02,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",2,192.83,24.83,48,216,8.7,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",4.35,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.04,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",2,263.67,95.67,192,360,2.52,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.26,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.01,"Sponsor123",11201 -"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.001,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 +"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,505.5,1.5,0.5,504.5,11.8,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.9,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.52,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,531.08,27.08,48,552,7.95,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.975,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",4,672.75,0.75,0,672,0.793,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.3965,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 @@ -688,7 +688,7 @@ "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",4,772.75,100.75,192,864,2.7,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.35,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.48,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",5,840.67,0.67,0,840,0.898,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.449,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.5,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,841.5,1.5,0.5,840.5,15.2,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",7.6,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.56,"Sponsor123",11201 -"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.00485,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 +"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,-1.663333333,-1.663333333,0,0,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"31/05/2022 13:36",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.49,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,1.716666667,1.716666667,0.5,0.5,9.38,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.69,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,5.446666667,5.446666667,4,4,8.99,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.495,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 @@ -696,18 +696,18 @@ "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,24.04666667,24.04666667,48,48,6.04,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.02,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.51,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,78.36666667,78.36666667,144,144,2.11,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.055,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,167.6866667,167.6866667,336,336,0.188,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.094,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,194.0866667,194.0866667,216,216,0.0788,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.0394,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.44,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.0055,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0015,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,194.0866667,194.0866667,216,216,0.0788,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.44,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,502.3866667,-1.613333333,0,504,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.8166667,1.816666667,0.5,504.5,8.42,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",4.21,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.56,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,670.4966667,166.4966667,336,840,0.154,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.077,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.55,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,693.2166667,189.2166667,384,888,0.0795,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.03975,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.01155,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,693.2166667,189.2166667,384,888,0.0795,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1007.416667,-0.583333333,0,1008,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.59,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1009.536667,1.536666667,0.5,1008.5,9.17,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",4.585,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.97,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1174.966667,166.9666667,336,1344,0.126,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.063,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.98,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.00155,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 "XX01","XX01-11203","Metab. of Analyte01","SERUM","EVERY WEEK",1,-1.086,-1.086,0,0,0,"Metab. of Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"02/06/2022 12:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.6,"Sponsor123",11203 "XX01","XX01-11203","Metab. of Analyte01","SERUM","EVERY WEEK",1,1.664,1.664,0.5,0.5,12.6,"Metab. of Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.3,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.57,"Sponsor123",11203 "XX01","XX01-11203","Metab. of Analyte01","SERUM","EVERY WEEK",1,6.084,6.084,4,4,14,"Metab. of Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",7,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.59,"Sponsor123",11203 @@ -749,7 +749,7 @@ "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.662,9.662,8,8,19.9,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",9.95,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.57,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",1,27.002,27.002,48,48,11.1,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.55,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.61,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",1,72.752,72.752,144,144,6.14,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.07,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.55,"Sponsor123",11204 -"XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0083,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 +"XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,506.662,2.662,0.5,504.5,13,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",6.5,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.26,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,530.502,26.502,48,552,13.4,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",6.7,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",3,671.712,-0.288,0,672,2.5,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.25,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 @@ -804,19 +804,19 @@ "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,75.49857143,75.49857143,144,144,6.61,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.305,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.72,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,170.7485714,170.7485714,336,336,2.59,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.295,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.74,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,338.0885714,338.0885714,672,672,0.349,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.1745,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.67,"Sponsor123",25101 -"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.00925,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 +"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,506.1885714,2.188571429,0.5,504.5,11.7,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.85,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.14,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,531.8885714,27.88857143,48,552,9,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",4.5,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.13,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,668.7185714,164.7185714,336,840,1.97,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.985,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,699.7185714,195.7185714,384,888,1.43,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.715,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,767.7185714,263.7185714,528,1032,0.69,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.345,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.23,"Sponsor123",25101 -"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.01055,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 +"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1010.048571,2.048571429,0.5,1008.5,13.3,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",6.65,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.63,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1177.548571,169.5485714,336,1344,2.05,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",1.025,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.54,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1345.298571,337.2985714,672,1680,0.32,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.16,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.58,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",4,1514.248571,1.748571429,0,1512.5,12.7,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",6.35,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.64,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",4,1681.088571,168.5885714,335.5,1848,2.29,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",1.145,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.6,"Sponsor123",25101 -"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.02,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 +"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",6,2017.968571,1.468571429,0,2016.5,8.69,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.32,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",4.345,"ug/mL",0,"13/09/2022 12:34",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","23/08/2022 11:35",149,64,"kg","cm",0.31,"Sponsor123",25101 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,-0.42,-0.42,0,0,0,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"16/06/2022 11:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.56,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,1.5,1.5,0.5,0.5,12.1,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.05,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.47,"Sponsor123",25102 @@ -826,13 +826,13 @@ "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.61,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.805,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.44,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,167.92,167.92,336,336,1.45,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.725,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.5,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.968,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.484,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.01575,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0017,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,5.25,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",2.625,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1.05,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,530.67,26.67,48,552,7.65,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.825,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,671.83,167.83,336,840,1.88,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.94,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.96,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,698.65,194.65,384,888,1.42,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.71,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.97,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.00345,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,10.2,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",5.1,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.54,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1176.22,168.22,336,1344,2,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",1,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.45,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1344.22,336.22,672,1680,0.147,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.0735,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.52,"Sponsor123",25102 @@ -843,7 +843,7 @@ "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,25.08,25.08,48,48,6.32,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.16,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.48,"Sponsor123",25103 "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.12,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.56,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.46,"Sponsor123",25103 "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,170.82,170.82,336,336,0.603,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.3015,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.5,"Sponsor123",25103 -"XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.00135,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 +"XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,503.95,503.95,NA,NA,0,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,-2.994285714,-2.994285714,0,0,0,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"19/07/2022 12:37",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,1.765714286,1.765714286,0.5,0.5,14.4,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",7.2,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.49,"Sponsor123",25104 @@ -852,8 +852,8 @@ "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,27.60571429,27.60571429,48,48,8.16,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",4.08,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.54,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,71.60571429,71.60571429,144,144,4.51,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.255,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,1.28,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.64,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 -"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.00935,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 -"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.001,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 +"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 +"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.6557143,1.655714286,0.5,504.5,12.1,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",6.05,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,527.8157143,23.81571429,48,552,9.64,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",4.82,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.51,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,677.0157143,173.0157143,336,840,1.65,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.825,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 @@ -995,7 +995,7 @@ "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",1,9.8,9.8,8,8,6.205749553,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.205749553,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.76,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",1,25.37,25.37,48,48,5.278321739,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.278321739,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.79,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",1,72.58,72.58,144,144,1.911402348,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.911402348,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.76,"Sponsor123",11108 -"XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,166.45,-1.55,0,168,0.018456611,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.018456611,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.71,"Sponsor123",11108 +"XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,166.45,-1.55,0,168,0.018456611,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.71,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,169.87,1.87,0.5,168.5,6.994037203,"Analyte01","intravascular",35,65,"M","WHITE",1.08,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",6.994037203,"ng/mL",0,"21/02/2022 13:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 16:05",168,60.7,"kg","cm",1.07,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,172.75,4.75,4,172,7.050359202,"Analyte01","intravascular",35,65,"M","WHITE",1.08,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.050359202,"ng/mL",0,"21/02/2022 13:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 16:05",168,60.7,"kg","cm",1.07,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,191.67,23.67,48,216,5.618470372,"Analyte01","intravascular",35,65,"M","WHITE",1.08,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",5.618470372,"ng/mL",0,"21/02/2022 13:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 16:05",168,60.7,"kg","cm",1.06,"Sponsor123",11108 @@ -1309,7 +1309,7 @@ "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY WEEK",2,503.67,-0.33,0,504,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.53,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,3.043295153,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.043295153,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,533,29,48,552,2.733320867,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.733320867,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.5,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.021953977,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.021953977,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.021953977,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,695.92,191.92,384,888,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.54,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,3.354203165,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",3.354203165,"ng/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.04,"Sponsor123",11101 @@ -1413,7 +1413,7 @@ "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",4,746.952,74.952,192,864,1.174330684,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.174330684,"ng/mL",0,"05/04/2022 12:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/03/2022 12:01",165,83.8,"kg","cm",0.62,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",5,840.752,0.752,0,840,0,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0,"ng/mL",0,"05/04/2022 12:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/03/2022 12:01",165,83.8,"kg","cm",0.59,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",5,841.832,1.832,0.5,840.5,7.844450395,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",7.844450395,"ng/mL",0,"12/04/2022 12:16",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","05/04/2022 12:58",165,83.8,"kg","cm",0.61,"Sponsor123",11107 -"XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",6,1007.782,-0.218,0,1008,0.041230449,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.041230449,"ng/mL",0,"12/04/2022 12:16",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","05/04/2022 12:58",165,83.8,"kg","cm",0.58,"Sponsor123",11107 +"XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",6,1007.782,-0.218,0,1008,0.041230449,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"12/04/2022 12:16",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","05/04/2022 12:58",165,83.8,"kg","cm",0.58,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",6,1009.662,1.662,0.5,1008.5,5.509762499,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",5.509762499,"ng/mL",0,"19/04/2022 13:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/04/2022 12:16",165,83.8,"kg","cm",0.52,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",7,1173.712,-2.288,0,1176,0,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0,"ng/mL",0,"19/04/2022 13:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/04/2022 12:16",165,83.8,"kg","cm",0.5,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",7,1177.882,1.882,0.5,1176.5,8.269199939,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",8.269199939,"ng/mL",0,"26/04/2022 12:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/04/2022 13:15",165,83.8,"kg","cm",0.57,"Sponsor123",11107 @@ -1622,7 +1622,7 @@ "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",3,674.632,2.632,0.5,672.5,6.782330318,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",6.782330318,"ng/mL",0,"14/07/2022 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 14:07",158,49.3,"kg","cm",2.15,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",4,840.332,0.332,0,840,0.99833855,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.99833855,"ng/mL",0,"14/07/2022 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 14:07",158,49.3,"kg","cm",2.12,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",4,842.662,2.662,0.5,840.5,6.784642191,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",6.784642191,"ng/mL",0,"28/07/2022 15:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/07/2022 12:55",158,49.3,"kg","cm",1.52,"Sponsor123",11204 -"XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",5,1008.832,0.832,0,1008,0.034722063,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.034722063,"ng/mL",0,"28/07/2022 15:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/07/2022 12:55",158,49.3,"kg","cm",1.54,"Sponsor123",11204 +"XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",5,1008.832,0.832,0,1008,0.034722063,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"28/07/2022 15:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/07/2022 12:55",158,49.3,"kg","cm",1.54,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",5,1010.662,2.662,0.5,1008.5,5.752836288,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.67,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",5.752836288,"ng/mL",0,"04/08/2022 11:41",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 15:15",158,49.3,"kg","cm",1.71,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",6,1176.982,0.982,0,1176,0.911808985,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.67,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.911808985,"ng/mL",0,"04/08/2022 11:41",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 15:15",158,49.3,"kg","cm",1.67,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",6,1178.652,2.652,0.5,1176.5,8.057737649,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.1,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",8.057737649,"ng/mL",0,"09/06/2022 20:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","04/08/2022 11:41",158,49.3,"kg","cm",1.07,"Sponsor123",11204 @@ -1691,7 +1691,7 @@ "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,25.5,25.5,48,48,3.82051373,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.82051373,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,73.5,73.5,144,144,1.188223986,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.188223986,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.44,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,167.92,167.92,336,336,0.314168016,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.314168016,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.5,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.041711459,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.041711459,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.041711459,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,336,336,672,672,0,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,504.33,0.33,0,504,0,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,2.212564682,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",2.212564682,"ng/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1.05,"Sponsor123",25102 @@ -1717,7 +1717,7 @@ "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,9.765714286,9.765714286,8,8,6.475188124,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.475188124,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,27.60571429,27.60571429,48,48,3.823118238,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.823118238,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.54,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,71.60571429,71.60571429,144,144,1.933920415,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.933920415,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 -"XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,0.048685909,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.048685909,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 +"XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,0.048685909,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,505.6557143,1.655714286,0.5,504.5,5.426375551,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.426375551,"ng/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 @@ -1763,46 +1763,46 @@ "XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,5.548333333,5.548333333,4,4,10.8,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.058409126,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 "XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,5.548333333,5.548333333,4,4,10.36464401,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.058409126,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 "XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,5.548333333,5.548333333,4,4,5.047901516,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.058409126,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,8.181893465,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,3.763972436,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,10.47706187,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,4.917609111,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.07652178,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,4.933665926,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,14.91208176,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,7.131524797,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,5.847310608,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,2.624298377,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,27,27,48,48,10.00408762,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,27,27,48,48,4.690083597,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,6.680462515,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,3.202902042,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,2.519461466,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,1.03432864,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.142675299,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,1.390436009,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,5.885567326,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,2.66811552,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,8.181893465,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,3.763972436,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,10.47706187,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,4.917609111,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.07652178,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,4.933665926,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,14.91208176,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,7.131524797,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,5.847310608,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,2.624298377,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,27,27,48,48,10.00408762,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,27,27,48,48,4.690083597,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,6.680462515,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,3.202902042,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,2.519461466,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,1.03432864,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.142675299,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,1.390436009,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,5.885567326,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,2.66811552,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,166.83,-1.17,0,168,1.02,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.02,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,166.83,-1.17,0,168,1.02,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.51,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,166.83,-1.17,0,168,0.613748741,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.613748741,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 @@ -1827,22 +1827,22 @@ "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.7,4.7,4,172,13.7,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.136429157,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,172.7,4.7,4,172,13.14878431,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.136429157,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,172.7,4.7,4,172,6.438060292,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.136429157,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,12.0608923,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,5.54137299,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,9.355778538,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,4.441899726,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,5.333241209,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,2.354235599,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,1.041181545,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,0.278658763,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,12.0608923,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,5.54137299,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,9.355778538,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,4.441899726,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,5.333241209,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,2.354235599,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,1.041181545,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,0.278658763,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",3,336.92,0.92,0,336,2.15,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",5.977785616,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,336.92,0.92,0,336,2.15,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",5.977785616,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,336.92,0.92,0,336,1.615339806,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",5.977785616,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 @@ -1851,12 +1851,12 @@ "XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,337.5,1.5,0.5,336.5,12.2,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",3.346952402,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,337.5,1.5,0.5,336.5,11.85937042,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",3.346952402,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",3,337.5,1.5,0.5,336.5,5.413133289,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",3.346952402,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,9.259674271,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,4.303346934,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0011,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.00055,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,9.259674271,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,4.303346934,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,503.18,-0.82,0,504,0,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,503.18,-0.82,0,504,0,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",4,504.83,0.83,0,504,2.45,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",6.540739295,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 @@ -1871,14 +1871,14 @@ "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,505.53,1.53,0.5,504.5,12.1,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.24803501,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,505.53,1.53,0.5,504.5,11.58635242,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.24803501,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,505.53,1.53,0.5,504.5,5.481440212,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.24803501,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,8.329548693,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,3.913289621,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,531,27,48,552,5.929618595,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,531,27,48,552,2.539113296,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,8.329548693,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,3.913289621,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,531,27,48,552,5.929618595,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,531,27,48,552,2.539113296,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,671.13,-0.87,0,672,0.91,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.91,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,671.13,-0.87,0,672,0.91,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.455,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,671.13,-0.87,0,672,0.412083557,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.412083557,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 @@ -1895,22 +1895,22 @@ "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,673.62,1.62,0.5,672.5,11.5,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.968480486,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,673.62,1.62,0.5,672.5,10.89343252,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.968480486,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,673.62,1.62,0.5,672.5,5.389411409,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.968480486,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,10.72193707,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,5.266087488,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,8.73558088,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,4.262302904,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,4.179376159,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,1.641646762,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,2.835053079,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,1.195996355,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,10.72193707,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,5.266087488,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,8.73558088,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,4.262302904,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,4.179376159,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,1.641646762,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,2.835053079,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,1.195996355,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",5,840.18,0.18,0,840,0.721,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",12.52905317,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",5,840.18,0.18,0,840,0.721,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",12.52905317,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",5,840.18,0.18,0,840,0.197022986,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",12.52905317,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 @@ -1923,8 +1923,8 @@ "XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",6,841.5,1.5,0.5,840.5,15.3,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.346952402,"ug/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",6,841.5,1.5,0.5,840.5,14.78576513,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.346952402,"ng/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",6,841.5,1.5,0.5,840.5,7.20730422,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.346952402,"ng/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0118,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Metab. of Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0059,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Metab. of Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",6,1006.73,-1.27,0,1008,0,"Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",6,1006.73,-1.27,0,1008,0,"Metab. of Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",7,1008.75,0.75,0,1008,2.35,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",7.085498291,"ug/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 From 5e3eee311bfb5bb0710f65c3ccc53df0284349b7 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 27 Jun 2025 09:56:57 +0200 Subject: [PATCH 11/47] spelling: update wordlist to include BLQ --- inst/WORDLIST | 1 + 1 file changed, 1 insertion(+) diff --git a/inst/WORDLIST b/inst/WORDLIST index 1e12e7100..7c5250722 100644 --- a/inst/WORDLIST +++ b/inst/WORDLIST @@ -8,6 +8,7 @@ AUClast AVAL AVALU Analyte +BLQ CDISC DOSEA DOSEU From b745304addcabd22133dffeedef29d4446686bf0 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Tue, 1 Jul 2025 10:05:58 +0200 Subject: [PATCH 12/47] feat: add option for "No BLQ handling" --- .../modules/tab_nca/setup/data_imputation.R | 20 ++++++++++++++----- 1 file changed, 15 insertions(+), 5 deletions(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 5c1bb5abc..72a0dbe78 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -22,17 +22,18 @@ data_imputation_ui <- function(id) { ns("select_blq_strategy"), "Select BLQ Imputation Strategy", choices = c( - "tmax based imputation", + "Tmax based imputation", "Positional BLQ imputation", - "Set value for all BLQ" + "Set value for all BLQ", + "No BLQ handling" ), - selected = "tmax based imputation" + selected = "Tmax based imputation" ), # Always render all inputs, but use conditionalPanel to show/hide div( style = "margin-top: 1em;", conditionalPanel( - condition = sprintf("input['%s'] == 'tmax based imputation'", ns("select_blq_strategy")), + condition = sprintf("input['%s'] == 'Tmax based imputation'", ns("select_blq_strategy")), blq_selectize(ns("before_tmax"), "Before tmax", selected = "0"), blq_selectize(ns("after_tmax"), "After tmax", selected = "drop") ), @@ -47,6 +48,10 @@ data_imputation_ui <- function(id) { conditionalPanel( condition = sprintf("input['%s'] == 'Set value for all BLQ'", ns("select_blq_strategy")), blq_selectize(ns("blq_value"), "Value for BLQ", selected = "0.05"), + ), + conditionalPanel( + condition = sprintf("input['%s'] == 'No BLQ handling'", ns("select_blq_strategy")), + helpText("No BLQ imputation will be applied. All values are kept as is") ) ) ) @@ -64,7 +69,7 @@ data_imputation_server <- function(id) { req(input$select_blq_strategy) rule_list <- switch( input$select_blq_strategy, - "tmax based imputation" = list( + "Tmax based imputation" = list( before.tmax = input$before_tmax, after.tmax = input$after_tmax ), @@ -78,6 +83,11 @@ data_imputation_server <- function(id) { middle = input$blq_value, last = input$blq_value ), + "No BLQ handling" = list( + first = "keep", + middle = "keep", + last = "keep" + ), NULL ) From 9c898ecca0a3046045732e86f2a812f1c0175f79 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Tue, 1 Jul 2025 10:41:47 +0200 Subject: [PATCH 13/47] data: reset dataset back ADNCA --- inst/shiny/data/Dummy_complex_data.csv | 302 ++++++++++++------------- 1 file changed, 151 insertions(+), 151 deletions(-) diff --git a/inst/shiny/data/Dummy_complex_data.csv b/inst/shiny/data/Dummy_complex_data.csv index d75fd9beb..9c3b747d9 100644 --- a/inst/shiny/data/Dummy_complex_data.csv +++ b/inst/shiny/data/Dummy_complex_data.csv @@ -5,22 +5,22 @@ "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,7.5,7.5,8,8,8.66,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",8.66,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.49,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,27.25,27.25,48,48,7.03,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",7.03,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.48,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,73.08,73.08,144,144,3.78,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.78,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.0063,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",1,2425.17,2425.17,NA,NA,0,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Safety Follow Up",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY WEEK",2,503.67,-0.33,0,504,0,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.53,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,7.28,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",7.28,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,533,29,48,552,6.25,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",6.25,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.955,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.955,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",2,695.92,191.92,384,888,0.68,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.68,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.54,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0031,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,7.99,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",7.99,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.04,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1182.58,174.58,336,1344,1.28,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",1.28,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.06,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",3,1345.83,337.83,672,1680,0.116,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.116,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.07,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0.0201,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1513.5,1.5,0.5,1512.5,8.73,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",8.73,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1683.17,171.17,336,1848,1.11,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",1.11,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.5,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",4,1849,337,672,2184,0.149,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",0.149,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 -"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 +"XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.0258,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2017.5,1.5,0.5,2016.5,6.84,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",6.84,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.48,"Sponsor123",11101 "XX01","XX01-11101","Analyte01","SERUM","EVERY 3 WEEKS",5,2184.08,168.08,336,2352,1.07,"Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 8",1.07,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.45,"Sponsor123",11101 "XX01","XX01-11102","Analyte01","SERUM","EVERY WEEK",1,170.25,1.75,0,168.5,14.9,"Analyte01","intravascular",35,74,"F","WHITE",1.55,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",14.9,"ug/mL",0,"18/08/2021 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","11/08/2021 15:53",163,54.9,"kg","cm",1.56,"Sponsor123",11102 @@ -105,7 +105,7 @@ "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",2,172.632,4.632,4,172,14.7,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",14.7,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.07,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",2,192.302,24.302,48,216,9.06,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",9.06,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.99,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",2,242.052,74.052,192,360,4.24,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",4.24,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.97,"Sponsor123",11107 -"XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 +"XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0058,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,505.862,1.862,0.5,504.5,23,"Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",23,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.56,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",3,531.452,27.452,48,552,7.62,"Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",7.62,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 "XX01","XX01-11107","Analyte01","SERUM","EVERY WEEK",4,672.612,0.612,0,672,0.6,"Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.6,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 @@ -144,22 +144,22 @@ "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",1,9.782,9.782,8,8,4.45,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.45,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",1,24.652,24.652,48,48,2.61,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.61,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.59,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",1,74.752,74.752,144,144,0.703,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0.703,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.55,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.024,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,169.612,1.612,0.5,168.5,7.83,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.83,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.12,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,172.582,4.582,4,172,6.47,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",6.47,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.19,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,193.582,25.582,48,216,3.47,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",3.47,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.11,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",2,265.512,97.512,192,360,0.102,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.102,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.14,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0105,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,337.532,1.532,0.5,336.5,9.79,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",9.79,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.65,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",3,361.712,25.712,48,384,3.89,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",3.89,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.62,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0111,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,505.582,1.582,0.5,504.5,7.5,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",7.5,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.49,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",4,529.062,25.062,48,552,2.2,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.2,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.47,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.0268,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,673.682,1.682,0.5,672.5,8.87,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",8.87,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.54,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,699.452,27.452,48,720,3.57,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",3.57,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",5,768.332,96.332,192,864,0.325,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.325,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.64,"Sponsor123",11109 -"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 +"XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.0378,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Analyte01","SERUM","EVERY WEEK",6,841.652,1.652,0.5,840.5,7.19,"Analyte01","intravascular",35,61,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",7.19,"ug/mL",0,"28/02/2022 18:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","04/04/2022 14:03",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11110","Analyte01","SERUM","EVERY WEEK",1,-0.846,-0.846,0,0,0,"Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/06/2022 15:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.54,"Sponsor123",11110 "XX01","XX01-11110","Analyte01","SERUM","EVERY WEEK",1,1.604,1.604,0.5,0.5,8.83,"Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",8.83,"ug/mL",0,"06/07/2022 11:18",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.49,"Sponsor123",11110 @@ -227,7 +227,7 @@ "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",2,172.72,4.72,4,172,10.5,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",10.5,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.41,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",2,191.67,23.67,48,216,8.15,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",8.15,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",2,237.08,69.08,192,360,2.09,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",2.09,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.49,"Sponsor123",11112 -"XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 +"XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0441,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",3,337.72,1.72,0.5,336.5,9.21,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",9.21,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.45,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY WEEK",4,504.3,0.3,0,504,0.108,"Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.108,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.5,"Sponsor123",11112 "XX01","XX01-11112","Analyte01","SERUM","EVERY 3 WEEKS",4,505.53,1.53,0.5,504.5,9.45,"Analyte01","intravascular",35,42,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",9.45,"ug/mL",0,"23/08/2022 11:13",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/08/2022 11:28",177,92.2,"kg","cm",0.97,"Sponsor123",11112 @@ -246,7 +246,7 @@ "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",2,172.5,4.5,4,172,10.7,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",10.7,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.02,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",2,192.83,24.83,48,216,8.7,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",8.7,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.04,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",2,263.67,95.67,192,360,2.52,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",2.52,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.01,"Sponsor123",11201 -"XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 +"XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.002,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,505.5,1.5,0.5,504.5,11.8,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",11.8,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.52,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",3,531.08,27.08,48,552,7.95,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",7.95,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",4,672.75,0.75,0,672,0.793,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.793,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 @@ -255,7 +255,7 @@ "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",4,772.75,100.75,192,864,2.7,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",2.7,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.48,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY WEEK",5,840.67,0.67,0,840,0.898,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.898,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.5,"Sponsor123",11201 "XX01","XX01-11201","Analyte01","SERUM","EVERY 3 WEEKS",5,841.5,1.5,0.5,840.5,15.2,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",15.2,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.56,"Sponsor123",11201 -"XX01","XX01-11201","Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 +"XX01","XX01-11201","Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.0097,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,-1.663333333,-1.663333333,0,0,0,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"31/05/2022 13:36",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.49,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,1.716666667,1.716666667,0.5,0.5,9.38,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",9.38,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,5.446666667,5.446666667,4,4,8.99,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",8.99,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 @@ -264,17 +264,17 @@ "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,78.36666667,78.36666667,144,144,2.11,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.11,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,167.6866667,167.6866667,336,336,0.188,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.188,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,194.0866667,194.0866667,216,216,0.0788,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.0788,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.44,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.011,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.003,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,502.3866667,-1.613333333,0,504,0,"Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,505.8166667,1.816666667,0.5,504.5,8.42,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",8.42,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.56,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,670.4966667,166.4966667,336,840,0.154,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.154,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.55,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,693.2166667,189.2166667,384,888,0.0795,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.0795,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.0231,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1007.416667,-0.583333333,0,1008,0,"Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.59,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1009.536667,1.536666667,0.5,1008.5,9.17,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",9.17,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.97,"Sponsor123",11202 "XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1174.966667,166.9666667,336,1344,0.126,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.126,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.98,"Sponsor123",11202 -"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 +"XX01","XX01-11202","Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.0031,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 "XX01","XX01-11203","Analyte01","SERUM","EVERY WEEK",1,-1.086,-1.086,0,0,0,"Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"02/06/2022 12:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.6,"Sponsor123",11203 "XX01","XX01-11203","Analyte01","SERUM","EVERY WEEK",1,1.664,1.664,0.5,0.5,12.6,"Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",12.6,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.57,"Sponsor123",11203 "XX01","XX01-11203","Analyte01","SERUM","EVERY WEEK",1,6.084,6.084,4,4,14,"Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",14,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.59,"Sponsor123",11203 @@ -316,7 +316,7 @@ "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",1,9.662,9.662,8,8,19.9,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",19.9,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.57,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",1,27.002,27.002,48,48,11.1,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",11.1,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.61,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",1,72.752,72.752,144,144,6.14,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",6.14,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.55,"Sponsor123",11204 -"XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 +"XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0166,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,506.662,2.662,0.5,504.5,13,"Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",13,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.26,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",2,530.502,26.502,48,552,13.4,"Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",13.4,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 "XX01","XX01-11204","Analyte01","SERUM","EVERY WEEK",3,671.712,-0.288,0,672,2.5,"Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.5,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 @@ -371,19 +371,19 @@ "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",1,75.49857143,75.49857143,144,144,6.61,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",6.61,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.72,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",1,170.7485714,170.7485714,336,336,2.59,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",2.59,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.74,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",1,338.0885714,338.0885714,672,672,0.349,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.349,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.67,"Sponsor123",25101 -"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 +"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0185,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,506.1885714,2.188571429,0.5,504.5,11.7,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",11.7,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.14,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,531.8885714,27.88857143,48,552,9,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",9,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.13,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,668.7185714,164.7185714,336,840,1.97,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.97,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,699.7185714,195.7185714,384,888,1.43,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",1.43,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",2,767.7185714,263.7185714,528,1032,0.69,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.69,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.23,"Sponsor123",25101 -"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 +"XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0211,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1010.048571,2.048571429,0.5,1008.5,13.3,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",13.3,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.63,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1177.548571,169.5485714,336,1344,2.05,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",2.05,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.54,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY 3 WEEKS",3,1345.298571,337.2985714,672,1680,0.32,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.32,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.58,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",4,1514.248571,1.748571429,0,1512.5,12.7,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",12.7,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.64,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",4,1681.088571,168.5885714,335.5,1848,2.29,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",2.29,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.6,"Sponsor123",25101 -"XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 +"XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.04,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 "XX01","XX01-25101","Analyte01","SERUM","EVERY WEEK",6,2017.968571,1.468571429,0,2016.5,8.69,"Analyte01","intravascular",35,70,"F","WHITE",0.32,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",8.69,"ug/mL",0,"13/09/2022 12:34",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","23/08/2022 11:35",149,64,"kg","cm",0.31,"Sponsor123",25101 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,-0.42,-0.42,0,0,0,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"16/06/2022 11:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.56,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,1.5,1.5,0.5,0.5,12.1,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",12.1,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.47,"Sponsor123",25102 @@ -393,13 +393,13 @@ "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.61,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.61,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.44,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,167.92,167.92,336,336,1.45,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.45,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.5,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.968,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.968,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 -"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 -"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 +"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0315,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 +"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0034,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,5.25,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.25,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1.05,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,530.67,26.67,48,552,7.65,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",7.65,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,671.83,167.83,336,840,1.88,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.88,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.96,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",2,698.65,194.65,384,888,1.42,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",1.42,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.97,"Sponsor123",25102 -"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 +"XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0069,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,10.2,"Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",10.2,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.54,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1176.22,168.22,336,1344,2,"Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",2,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.45,"Sponsor123",25102 "XX01","XX01-25102","Analyte01","SERUM","EVERY 3 WEEKS",3,1344.22,336.22,672,1680,0.147,"Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.147,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.52,"Sponsor123",25102 @@ -410,7 +410,7 @@ "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,25.08,25.08,48,48,6.32,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.32,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.48,"Sponsor123",25103 "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.12,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.12,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.46,"Sponsor123",25103 "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,170.82,170.82,336,336,0.603,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.603,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.5,"Sponsor123",25103 -"XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 +"XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0027,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25103","Analyte01","SERUM","EVERY 3 WEEKS",1,503.95,503.95,NA,NA,0,"Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,-2.994285714,-2.994285714,0,0,0,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"19/07/2022 12:37",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,1.765714286,1.765714286,0.5,0.5,14.4,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",14.4,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.49,"Sponsor123",25104 @@ -419,8 +419,8 @@ "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,27.60571429,27.60571429,48,48,8.16,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",8.16,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.54,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,71.60571429,71.60571429,144,144,4.51,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",4.51,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,1.28,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.28,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 -"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 -"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 +"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0187,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 +"XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.002,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,505.6557143,1.655714286,0.5,504.5,12.1,"Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",12.1,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,527.8157143,23.81571429,48,552,9.64,"Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",9.64,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.51,"Sponsor123",25104 "XX01","XX01-25104","Analyte01","SERUM","EVERY 3 WEEKS",2,677.0157143,173.0157143,336,840,1.65,"Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.65,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 @@ -438,22 +438,22 @@ "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,7.5,7.5,8,8,8.66,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.33,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.49,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,27.25,27.25,48,48,7.03,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.515,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.48,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.08,73.08,144,144,3.78,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.89,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,383.67,383.67,NA,NA,0.0063,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.00315,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.51,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",1,2425.17,2425.17,NA,NA,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Safety Follow Up",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY WEEK",2,503.67,-0.33,0,504,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.53,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,7.28,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.64,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,533,29,48,552,6.25,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.125,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.5,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.955,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.4775,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,695.92,191.92,384,888,0.68,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.34,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.54,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0031,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.00155,"ug/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,7.99,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",3.995,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.04,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1182.58,174.58,336,1344,1.28,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.64,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.06,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1345.83,337.83,672,1680,0.116,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.058,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.07,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1512.92,0.92,0,1512,0.0201,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0.01005,"ug/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",0.95,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1513.5,1.5,0.5,1512.5,8.73,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",4.365,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1683.17,171.17,336,1848,1.11,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",0.555,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.5,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,1849,337,672,2184,0.149,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",0.0745,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.49,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2016.92,0.92,0,2016,0.0258,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.0129,"ug/mL",0,"17/08/2022 16:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2022 11:00",173,90,"kg","cm",0.56,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2017.5,1.5,0.5,2016.5,6.84,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",3.42,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.48,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,2184.08,168.08,336,2352,1.07,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 5 Day 8",0.535,"ug/mL",0,"27/07/2021 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","17/08/2022 16:25",173,90,"kg","cm",0.45,"Sponsor123",11101 "XX01","XX01-11102","Metab. of Analyte01","SERUM","EVERY WEEK",1,170.25,1.75,0,168.5,14.9,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",1.55,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.45,"ug/mL",0,"18/08/2021 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","11/08/2021 15:53",163,54.9,"kg","cm",1.56,"Sponsor123",11102 @@ -515,7 +515,7 @@ "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",9,1345.58,1.58,0.5,1344.5,3.61,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",1.805,"ug/mL",0,"18/11/2021 11:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/11/2021 13:15",168,102.6,"kg","cm",0.54,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",10,1511.75,-0.25,0,1512,0.271,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",0.1355,"ug/mL",0,"18/11/2021 11:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/11/2021 13:15",168,102.6,"kg","cm",0.54,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",10,1513.53,1.53,0.5,1512.5,4.6,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",2.3,"ug/mL",0,"29/11/2021 13:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","18/11/2021 11:50",168,102.6,"kg","cm",0.61,"Sponsor123",11103 -"XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",11,1680.08,0.08,0,1680,0.0917,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",0,"ug/mL",0,"29/11/2021 13:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","18/11/2021 11:50",168,102.6,"kg","cm",0.57,"Sponsor123",11103 +"XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",11,1680.08,0.08,0,1680,0.0917,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",0.04585,"ug/mL",0,"29/11/2021 13:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","18/11/2021 11:50",168,102.6,"kg","cm",0.57,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",11,1681.58,1.58,0.5,1680.5,4.52,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",2.26,"ug/mL",0,"07/12/2021 13:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 13:20",168,102.6,"kg","cm",0.58,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",12,1848.67,0.67,0,1848,0.4,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",0.2,"ug/mL",0,"07/12/2021 13:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 13:20",168,102.6,"kg","cm",0.53,"Sponsor123",11103 "XX01","XX01-11103","Metab. of Analyte01","SERUM","EVERY WEEK",12,1849.67,1.67,0.5,1848.5,6.72,"Metab. of Analyte01","intravascular",35,41,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 15",3.36,"ug/mL",0,"14/12/2021 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/12/2021 13:30",168,102.6,"kg","cm",0.59,"Sponsor123",11103 @@ -538,7 +538,7 @@ "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.632,4.632,4,172,14.7,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.35,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.07,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",2,192.302,24.302,48,216,9.06,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",4.53,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.99,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",2,242.052,74.052,192,360,4.24,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",2.12,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",0.97,"Sponsor123",11107 -"XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 +"XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.702,0.702,0,504,0.0058,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",1.03,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0029,"ug/mL",0,"22/03/2022 11:26",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","08/03/2022 12:40",165,83.8,"kg","cm",1.03,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,505.862,1.862,0.5,504.5,23,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",11.5,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.56,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",3,531.452,27.452,48,552,7.62,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.81,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","SERUM","EVERY WEEK",4,672.612,0.612,0,672,0.6,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.3,"ug/mL",0,"29/03/2022 12:01",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/03/2022 11:26",165,83.8,"kg","cm",0.54,"Sponsor123",11107 @@ -577,22 +577,22 @@ "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.782,9.782,8,8,4.45,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",2.225,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",1,24.652,24.652,48,48,2.61,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",1.305,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.59,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",1,74.752,74.752,144,144,0.703,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0.3515,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.55,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,167.962,-0.038,0,168,0.024,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.012,"ug/mL",0,"07/03/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/02/2022 12:35",172,100.3,"kg","cm",1.52,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,169.612,1.612,0.5,168.5,7.83,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",3.915,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.12,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.582,4.582,4,172,6.47,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",3.235,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.19,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,193.582,25.582,48,216,3.47,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.735,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.11,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",2,265.512,97.512,192,360,0.102,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.051,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.14,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,336.202,0.202,0,336,0.0105,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.00525,"ug/mL",0,"14/03/2022 11:52",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/03/2022 11:35",172,100.3,"kg","cm",1.18,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,337.532,1.532,0.5,336.5,9.79,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",4.895,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.65,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",3,361.712,25.712,48,384,3.89,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",1.945,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.62,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,504.332,0.332,0,504,0.0111,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.65,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.00555,"ug/mL",0,"21/03/2022 11:27",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/03/2022 11:52",172,100.3,"kg","cm",0.67,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,505.582,1.582,0.5,504.5,7.5,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.75,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.49,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",4,529.062,25.062,48,552,2.2,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.1,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.47,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,672.102,0.102,0,672,0.0268,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.0134,"ug/mL",0,"28/03/2022 12:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/03/2022 11:27",172,100.3,"kg","cm",0.5,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,673.682,1.682,0.5,672.5,8.87,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",4.435,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.54,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,699.452,27.452,48,720,3.57,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",1.785,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",5,768.332,96.332,192,864,0.325,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.1625,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.64,"Sponsor123",11109 -"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 +"XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",6,838.562,-1.438,0,840,0.0378,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.0189,"ug/mL",0,"04/04/2022 14:03",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/03/2022 12:06",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11109","Metab. of Analyte01","SERUM","EVERY WEEK",6,841.652,1.652,0.5,840.5,7.19,"Metab. of Analyte01","intravascular",35,61,"M","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.595,"ug/mL",0,"28/02/2022 18:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","04/04/2022 14:03",172,100.3,"kg","cm",0.6,"Sponsor123",11109 "XX01","XX01-11110","Metab. of Analyte01","SERUM","EVERY WEEK",1,-0.846,-0.846,0,0,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/06/2022 15:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.54,"Sponsor123",11110 "XX01","XX01-11110","Metab. of Analyte01","SERUM","EVERY WEEK",1,1.604,1.604,0.5,0.5,8.83,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.415,"ug/mL",0,"06/07/2022 11:18",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/06/2022 15:06",170,70,"kg","cm",1.49,"Sponsor123",11110 @@ -660,7 +660,7 @@ "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.72,4.72,4,172,10.5,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",5.25,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.41,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",2,191.67,23.67,48,216,8.15,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",4.075,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",2,237.08,69.08,192,360,2.09,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.045,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.49,"Sponsor123",11112 -"XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 +"XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",3,334.73,-1.27,0,336,0.0441,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.02205,"ug/mL",0,"09/08/2022 11:54",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 13:14",177,92.2,"kg","cm",1.43,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",3,337.72,1.72,0.5,336.5,9.21,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",4.605,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.45,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY WEEK",4,504.3,0.3,0,504,0.108,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1.48,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.054,"ug/mL",0,"16/08/2022 11:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 11:54",177,92.2,"kg","cm",1.5,"Sponsor123",11112 "XX01","XX01-11112","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",4,505.53,1.53,0.5,504.5,9.45,"Metab. of Analyte01","intravascular",35,42,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",4.725,"ug/mL",0,"23/08/2022 11:13",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/08/2022 11:28",177,92.2,"kg","cm",0.97,"Sponsor123",11112 @@ -679,7 +679,7 @@ "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.5,4.5,4,172,10.7,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",5.35,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.02,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",2,192.83,24.83,48,216,8.7,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",4.35,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.04,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",2,263.67,95.67,192,360,2.52,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.26,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",1.01,"Sponsor123",11201 -"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 +"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,504.83,0.83,0,504,0.002,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.001,"ug/mL",0,"26/05/2022 12:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/05/2022 13:10",185,83,"kg","cm",0.96,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,505.5,1.5,0.5,504.5,11.8,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.9,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.52,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",3,531.08,27.08,48,552,7.95,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.975,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",4,672.75,0.75,0,672,0.793,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.3965,"ug/mL",0,"02/06/2022 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","26/05/2022 12:50",185,83,"kg","cm",0.51,"Sponsor123",11201 @@ -688,7 +688,7 @@ "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",4,772.75,100.75,192,864,2.7,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.35,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.48,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY WEEK",5,840.67,0.67,0,840,0.898,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.449,"ug/mL",0,"09/06/2022 14:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 14:00",185,83,"kg","cm",0.5,"Sponsor123",11201 "XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,841.5,1.5,0.5,840.5,15.2,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",7.6,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.56,"Sponsor123",11201 -"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 +"XX01","XX01-11201","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",5,1200,360,NA,NA,0.0097,"Metab. of Analyte01","intravascular",50,56,"M","WHITE",0.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0.00485,"ug/mL",0,"05/05/2022 17:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 14:50",185,83,"kg","cm",0.47,"Sponsor123",11201 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,-1.663333333,-1.663333333,0,0,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"31/05/2022 13:36",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.49,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,1.716666667,1.716666667,0.5,0.5,9.38,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.69,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,5.446666667,5.446666667,4,4,8.99,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",4.495,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.46,"Sponsor123",11202 @@ -696,18 +696,18 @@ "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,24.04666667,24.04666667,48,48,6.04,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.02,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.51,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,78.36666667,78.36666667,144,144,2.11,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.055,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,167.6866667,167.6866667,336,336,0.188,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.094,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,194.0866667,194.0866667,216,216,0.0788,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.44,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,194.0866667,194.0866667,216,216,0.0788,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.0394,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.44,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,263.5866667,263.5866667,360,360,0.011,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0.0055,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,335.9466667,335.9466667,672,672,0.003,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.0015,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,502.3866667,-1.613333333,0,504,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.47,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:49",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:36",185,78.9,"kg","cm",1.47,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.8166667,1.816666667,0.5,504.5,8.42,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",4.21,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.56,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,670.4966667,166.4966667,336,840,0.154,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.077,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.55,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,693.2166667,189.2166667,384,888,0.0795,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,693.2166667,189.2166667,384,888,0.0795,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.03975,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,741.5966667,237.5966667,528,1032,0.0231,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.01155,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.62,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1007.416667,-0.583333333,0,1008,0,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:49",185,78.9,"kg","cm",1.59,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1009.536667,1.536666667,0.5,1008.5,9.17,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",4.585,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.97,"Sponsor123",11202 "XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1174.966667,166.9666667,336,1344,0.126,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.063,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",0.98,"Sponsor123",11202 -"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 +"XX01","XX01-11202","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1341.786667,333.7866667,672,1680,0.0031,"Metab. of Analyte01","intravascular",35,65,"M","WHITE",0.98,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.00155,"ug/mL",0,"31/05/2022 19:28",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 12:56",185,78.9,"kg","cm",1.03,"Sponsor123",11202 "XX01","XX01-11203","Metab. of Analyte01","SERUM","EVERY WEEK",1,-1.086,-1.086,0,0,0,"Metab. of Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"02/06/2022 12:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.6,"Sponsor123",11203 "XX01","XX01-11203","Metab. of Analyte01","SERUM","EVERY WEEK",1,1.664,1.664,0.5,0.5,12.6,"Metab. of Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.3,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.57,"Sponsor123",11203 "XX01","XX01-11203","Metab. of Analyte01","SERUM","EVERY WEEK",1,6.084,6.084,4,4,14,"Metab. of Analyte01","intravascular",50,66,"M","WHITE",1.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",7,"ug/mL",0,"09/06/2022 14:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/06/2022 12:30",174,75.5,"kg","cm",1.59,"Sponsor123",11203 @@ -749,7 +749,7 @@ "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.662,9.662,8,8,19.9,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",9.95,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.57,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",1,27.002,27.002,48,48,11.1,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.55,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.61,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",1,72.752,72.752,144,144,6.14,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.07,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.55,"Sponsor123",11204 -"XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 +"XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,503.002,-0.998,0,504,0.0166,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0083,"ug/mL",0,"30/06/2022 13:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/06/2022 13:35",158,49.3,"kg","cm",2.53,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,506.662,2.662,0.5,504.5,13,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",6.5,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.26,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",2,530.502,26.502,48,552,13.4,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",6.7,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","SERUM","EVERY WEEK",3,671.712,-0.288,0,672,2.5,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",3.3,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",1.25,"ug/mL",0,"07/07/2022 14:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","30/06/2022 13:55",158,49.3,"kg","cm",3.29,"Sponsor123",11204 @@ -804,19 +804,19 @@ "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,75.49857143,75.49857143,144,144,6.61,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",3.305,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.72,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,170.7485714,170.7485714,336,336,2.59,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.295,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.74,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,338.0885714,338.0885714,672,672,0.349,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.1745,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.67,"Sponsor123",25101 -"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 +"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.2985714,0.298571429,0,504,0.0185,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.72,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.00925,"ug/mL",0,"21/06/2022 13:50",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/05/2022 13:13",149,64,"kg","cm",1.71,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,506.1885714,2.188571429,0.5,504.5,11.7,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.85,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.14,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,531.8885714,27.88857143,48,552,9,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",4.5,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.13,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,668.7185714,164.7185714,336,840,1.97,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.985,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,699.7185714,195.7185714,384,888,1.43,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.715,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.17,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,767.7185714,263.7185714,528,1032,0.69,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0.345,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.23,"Sponsor123",25101 -"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 +"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.388571,0.388571429,0,1008,0.0211,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",1.17,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.01055,"ug/mL",0,"12/07/2022 11:20",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 13:50",149,64,"kg","cm",1.1,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1010.048571,2.048571429,0.5,1008.5,13.3,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",6.65,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.63,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1177.548571,169.5485714,336,1344,2.05,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",1.025,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.54,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1345.298571,337.2985714,672,1680,0.32,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.16,"ug/mL",0,"02/08/2022 10:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/07/2022 11:20",149,64,"kg","cm",0.58,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",4,1514.248571,1.748571429,0,1512.5,12.7,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 1",6.35,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.64,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",4,1681.088571,168.5885714,335.5,1848,2.29,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 4 Day 8",1.145,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.6,"Sponsor123",25101 -"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 +"XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",5,2016.468571,0.468571429,0,2016,0.04,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",0.02,"ug/mL",0,"23/08/2022 11:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","02/08/2022 10:58",149,64,"kg","cm",0.57,"Sponsor123",25101 "XX01","XX01-25101","Metab. of Analyte01","SERUM","EVERY WEEK",6,2017.968571,1.468571429,0,2016.5,8.69,"Metab. of Analyte01","intravascular",35,70,"F","WHITE",0.32,"Hours","mg",0,"Analyte01","Cycle 5 Day 1",4.345,"ug/mL",0,"13/09/2022 12:34",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","23/08/2022 11:35",149,64,"kg","cm",0.31,"Sponsor123",25101 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,-0.42,-0.42,0,0,0,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"16/06/2022 11:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.56,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,1.5,1.5,0.5,0.5,12.1,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.05,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.47,"Sponsor123",25102 @@ -826,13 +826,13 @@ "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.61,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.805,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.44,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,167.92,167.92,336,336,1.45,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.725,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.5,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.968,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.484,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,336,336,672,672,0.0315,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.01575,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,504.33,0.33,0,504,0.0034,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0017,"ug/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,5.25,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",2.625,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1.05,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,530.67,26.67,48,552,7.65,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",3.825,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,671.83,167.83,336,840,1.88,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.94,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.96,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,698.65,194.65,384,888,1.42,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0.71,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",0.97,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0.0069,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.00345,"ug/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,10.2,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",5.1,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.54,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1176.22,168.22,336,1344,2,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",1,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.45,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",3,1344.22,336.22,672,1680,0.147,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 15",0.0735,"ug/mL",0,"14/09/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 10:10",168.9,50,"kg","cm",0.52,"Sponsor123",25102 @@ -843,7 +843,7 @@ "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,25.08,25.08,48,48,6.32,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.16,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.48,"Sponsor123",25103 "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,73.5,73.5,144,144,3.12,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.56,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.46,"Sponsor123",25103 "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,170.82,170.82,336,336,0.603,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.3015,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.5,"Sponsor123",25103 -"XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 +"XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,338.55,338.55,672,672,0.0027,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.00135,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25103","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,503.95,503.95,NA,NA,0,"Metab. of Analyte01","intravascular",35,46,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Discontinuation Visit",0,"ug/mL",0,"21/06/2022 18:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","21/06/2022 12:30",180,67.1,"kg","cm",1.47,"Sponsor123",25103 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,-2.994285714,-2.994285714,0,0,0,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"19/07/2022 12:37",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,1.765714286,1.765714286,0.5,0.5,14.4,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",7.2,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.49,"Sponsor123",25104 @@ -852,8 +852,8 @@ "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,27.60571429,27.60571429,48,48,8.16,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",4.08,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.54,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,71.60571429,71.60571429,144,144,4.51,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.255,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,1.28,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.64,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 -"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 -"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 +"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0.0187,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0.00935,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 +"XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0.002,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.001,"ug/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,505.6557143,1.655714286,0.5,504.5,12.1,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",6.05,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,527.8157143,23.81571429,48,552,9.64,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",4.82,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.51,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","SERUM","EVERY 3 WEEKS",2,677.0157143,173.0157143,336,840,1.65,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.825,"ug/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 @@ -995,7 +995,7 @@ "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",1,9.8,9.8,8,8,6.205749553,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.205749553,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.76,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",1,25.37,25.37,48,48,5.278321739,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.278321739,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.79,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",1,72.58,72.58,144,144,1.911402348,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.911402348,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.76,"Sponsor123",11108 -"XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,166.45,-1.55,0,168,0.018456611,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.71,"Sponsor123",11108 +"XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,166.45,-1.55,0,168,0.018456611,"Analyte01","intravascular",35,65,"M","WHITE",1.75,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.018456611,"ng/mL",0,"14/02/2022 16:05",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 15:50",168,60.7,"kg","cm",1.71,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,169.87,1.87,0.5,168.5,6.994037203,"Analyte01","intravascular",35,65,"M","WHITE",1.08,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",6.994037203,"ng/mL",0,"21/02/2022 13:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 16:05",168,60.7,"kg","cm",1.07,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,172.75,4.75,4,172,7.050359202,"Analyte01","intravascular",35,65,"M","WHITE",1.08,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",7.050359202,"ng/mL",0,"21/02/2022 13:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 16:05",168,60.7,"kg","cm",1.07,"Sponsor123",11108 "XX01","XX01-11108","Analyte01","CSF","EVERY WEEK",2,191.67,23.67,48,216,5.618470372,"Analyte01","intravascular",35,65,"M","WHITE",1.08,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",5.618470372,"ng/mL",0,"21/02/2022 13:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 16:05",168,60.7,"kg","cm",1.06,"Sponsor123",11108 @@ -1309,7 +1309,7 @@ "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY WEEK",2,503.67,-0.33,0,504,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"15/06/2022 11:25",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/07/2021 12:30",173,90,"kg","cm",1.53,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,3.043295153,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.043295153,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,533,29,48,552,2.733320867,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.733320867,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.5,"Sponsor123",11101 -"XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.021953977,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 +"XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,671.58,167.58,336,840,0.021953977,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.021953977,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.45,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,695.92,191.92,384,888,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.54,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",3,1008.33,0.33,0,1008,0,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"06/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","15/06/2022 11:25",173,90,"kg","cm",1.47,"Sponsor123",11101 "XX01","XX01-11101","Metab. of Analyte01","CSF","EVERY 3 WEEKS",3,1009.5,1.5,0.5,1008.5,3.354203165,"Metab. of Analyte01","intravascular",35,52,"M","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",3.354203165,"ng/mL",0,"27/07/2022 11:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/07/2022 11:00",173,90,"kg","cm",1.04,"Sponsor123",11101 @@ -1413,7 +1413,7 @@ "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",4,746.952,74.952,192,864,1.174330684,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.174330684,"ng/mL",0,"05/04/2022 12:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/03/2022 12:01",165,83.8,"kg","cm",0.62,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",5,840.752,0.752,0,840,0,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0,"ng/mL",0,"05/04/2022 12:58",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/03/2022 12:01",165,83.8,"kg","cm",0.59,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",5,841.832,1.832,0.5,840.5,7.844450395,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",7.844450395,"ng/mL",0,"12/04/2022 12:16",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","05/04/2022 12:58",165,83.8,"kg","cm",0.61,"Sponsor123",11107 -"XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",6,1007.782,-0.218,0,1008,0.041230449,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"12/04/2022 12:16",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","05/04/2022 12:58",165,83.8,"kg","cm",0.58,"Sponsor123",11107 +"XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",6,1007.782,-0.218,0,1008,0.041230449,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.58,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.041230449,"ng/mL",0,"12/04/2022 12:16",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","05/04/2022 12:58",165,83.8,"kg","cm",0.58,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",6,1009.662,1.662,0.5,1008.5,5.509762499,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",5.509762499,"ng/mL",0,"19/04/2022 13:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/04/2022 12:16",165,83.8,"kg","cm",0.52,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",7,1173.712,-2.288,0,1176,0,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0,"ng/mL",0,"19/04/2022 13:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","12/04/2022 12:16",165,83.8,"kg","cm",0.5,"Sponsor123",11107 "XX01","XX01-11107","Metab. of Analyte01","CSF","EVERY WEEK",7,1177.882,1.882,0.5,1176.5,8.269199939,"Metab. of Analyte01","intravascular",35,48,"F","WHITE",0.55,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",8.269199939,"ng/mL",0,"26/04/2022 12:07",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/04/2022 13:15",165,83.8,"kg","cm",0.57,"Sponsor123",11107 @@ -1622,7 +1622,7 @@ "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",3,674.632,2.632,0.5,672.5,6.782330318,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",6.782330318,"ng/mL",0,"14/07/2022 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 14:07",158,49.3,"kg","cm",2.15,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",4,840.332,0.332,0,840,0.99833855,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",2.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",0.99833855,"ng/mL",0,"14/07/2022 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 14:07",158,49.3,"kg","cm",2.12,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",4,842.662,2.662,0.5,840.5,6.784642191,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",6.784642191,"ng/mL",0,"28/07/2022 15:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/07/2022 12:55",158,49.3,"kg","cm",1.52,"Sponsor123",11204 -"XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",5,1008.832,0.832,0,1008,0.034722063,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"28/07/2022 15:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/07/2022 12:55",158,49.3,"kg","cm",1.54,"Sponsor123",11204 +"XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",5,1008.832,0.832,0,1008,0.034722063,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.034722063,"ng/mL",0,"28/07/2022 15:15",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/07/2022 12:55",158,49.3,"kg","cm",1.54,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",5,1010.662,2.662,0.5,1008.5,5.752836288,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.67,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",5.752836288,"ng/mL",0,"04/08/2022 11:41",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 15:15",158,49.3,"kg","cm",1.71,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",6,1176.982,0.982,0,1176,0.911808985,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.67,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",0.911808985,"ng/mL",0,"04/08/2022 11:41",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","28/07/2022 15:15",158,49.3,"kg","cm",1.67,"Sponsor123",11204 "XX01","XX01-11204","Metab. of Analyte01","CSF","EVERY WEEK",6,1178.652,2.652,0.5,1176.5,8.057737649,"Metab. of Analyte01","intravascular",50,69,"F","WHITE",1.1,"Hours","mg",0,"Analyte01","Cycle 3 Day 8",8.057737649,"ng/mL",0,"09/06/2022 20:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","04/08/2022 11:41",158,49.3,"kg","cm",1.07,"Sponsor123",11204 @@ -1691,7 +1691,7 @@ "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,25.5,25.5,48,48,3.82051373,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.82051373,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,73.5,73.5,144,144,1.188223986,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.188223986,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.44,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,167.92,167.92,336,336,0.314168016,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.314168016,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.5,"Sponsor123",25102 -"XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.041711459,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 +"XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,195.18,195.18,216,216,0.041711459,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0.041711459,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.51,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,336,336,672,672,0,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.45,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,504.33,0.33,0,504,0,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"07/07/2022 15:40",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","16/06/2022 11:10",168.9,50,"kg","cm",1.53,"Sponsor123",25102 "XX01","XX01-25102","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,505.5,1.5,0.5,504.5,2.212564682,"Metab. of Analyte01","intravascular",35,64,"M","ASIAN",1,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",2.212564682,"ng/mL",0,"28/07/2022 10:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/07/2022 15:40",168.9,50,"kg","cm",1.05,"Sponsor123",25102 @@ -1717,7 +1717,7 @@ "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,9.765714286,9.765714286,8,8,6.475188124,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",6.475188124,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,27.60571429,27.60571429,48,48,3.823118238,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",3.823118238,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.54,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,71.60571429,71.60571429,144,144,1.933920415,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.933920415,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.52,"Sponsor123",25104 -"XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,0.048685909,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 +"XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,165.9157143,165.9157143,336,336,0.048685909,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.048685909,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",1,333.3857143,333.3857143,672,672,0,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",0,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.53,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,503.1357143,-0.864285714,0,504,0,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.53,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"09/08/2022 14:06",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","19/07/2022 12:37",165,71.9,"kg","cm",1.55,"Sponsor123",25104 "XX01","XX01-25104","Metab. of Analyte01","CSF","EVERY 3 WEEKS",2,505.6557143,1.655714286,0.5,504.5,5.426375551,"Metab. of Analyte01","intravascular",35,67,"M","WHITE",1.52,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",5.426375551,"ng/mL",0,"30/08/2022 10:48",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","09/08/2022 14:06",165,71.9,"kg","cm",1.5,"Sponsor123",25104 @@ -1763,46 +1763,46 @@ "XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,5.548333333,5.548333333,4,4,10.8,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.058409126,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 "XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,5.548333333,5.548333333,4,4,10.36464401,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.058409126,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 "XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,5.548333333,5.548333333,4,4,5.047901516,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.058409126,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,8.181893465,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,3.763972436,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,10.47706187,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,4.917609111,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.07652178,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,4.933665926,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,14.91208176,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,7.131524797,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,5.847310608,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,2.624298377,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,27,27,48,48,10.00408762,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,27,27,48,48,4.690083597,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,6.680462515,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,3.202902042,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,2.519461466,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,1.03432864,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.142675299,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,1.390436009,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,5.885567326,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,2.66811552,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",0,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,5.98,5.98,4,4,8.66,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,8.181893465,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,5.98,5.98,4,4,3.763972436,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.037932394,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,7.78,7.78,8,8,11,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,10.47706187,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,7.78,7.78,8,8,4.917609111,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.006270183,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.5,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,10.07652178,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,9.218333333,9.218333333,8,8,4.933665926,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001488058,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,9.5,9.5,8,8,15.4,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,14.91208176,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,9.5,9.5,8,8,7.131524797,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 1",0.001122777,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,26.35,26.35,48,48,6.36,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,5.847310608,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,26.35,26.35,48,48,2.624298377,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",5.4e-11,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,27,27,48,48,10.3,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,27,27,48,48,10.00408762,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,27,27,48,48,4.690083597,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",2.82e-11,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,28.46833333,28.46833333,48,48,7.16,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,6.680462515,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,28.46833333,28.46833333,48,48,3.202902042,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 2",6.49e-12,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.13,73.13,144,144,3.01,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,2.519461466,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",1,73.13,73.13,144,144,1.03432864,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",2.61e-31,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11105","Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","SERUM","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.67,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ug/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,3.142675299,"Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11105","Metab. of Analyte01","CSF","EVERY WEEK",1,73.63833333,73.63833333,144,144,1.390436009,"Metab. of Analyte01","intravascular",35,74,"F","WHITE",2.02,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",1.57e-31,"ng/mL",0,"29/11/2021 19:45",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/11/2021 12:48",163,67.7,"kg","cm",0,"Sponsor123",11105 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",1,76.67,76.67,144,144,6.44,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ug/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,5.885567326,"Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",1,76.67,76.67,144,144,2.66811552,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 4",7.56e-33,"ng/mL",0,"29/09/2021 15:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","22/09/2021 10:45",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,166.83,-1.17,0,168,1.02,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",1.02,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,166.83,-1.17,0,168,1.02,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.51,"ug/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,166.83,-1.17,0,168,0.613748741,"Analyte01","intravascular",35,45,"M","WHITE",1.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.613748741,"ng/mL",0,"10/01/2022 13:51",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","03/01/2022 11:54",188,90,"kg","cm",0,"Sponsor123",11106 @@ -1827,22 +1827,22 @@ "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,172.7,4.7,4,172,13.7,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.136429157,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,172.7,4.7,4,172,13.14878431,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.136429157,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,172.7,4.7,4,172,6.438060292,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 8",0.136429157,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,12.0608923,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,5.54137299,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,9.355778538,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,4.441899726,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,5.333241209,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,2.354235599,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,1.041181545,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,0.278658763,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,191.83,23.83,48,216,12.6,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,12.0608923,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,191.83,23.83,48,216,5.54137299,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",6.71e-10,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,193.58,25.58,48,216,9.84,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,9.355778538,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,193.58,25.58,48,216,4.441899726,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 9",1.17e-10,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",2,263.5,95.5,192,360,5.76,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,5.333241209,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",2,263.5,95.5,192,360,2.354235599,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",5.02e-41,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",2,264.45,96.45,192,360,1.43,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,1.041181545,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",2,264.45,96.45,192,360,0.278658763,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 1 Day 12",1.94e-41,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",3,336.92,0.92,0,336,2.15,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",5.977785616,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,336.92,0.92,0,336,2.15,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",5.977785616,"ug/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,336.92,0.92,0,336,1.615339806,"Analyte01","intravascular",35,57,"F","WHITE",1,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",5.977785616,"ng/mL",0,"06/10/2021 16:30",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","29/09/2021 15:30",161,48.8,"kg","cm",0,"Sponsor123",11104 @@ -1851,12 +1851,12 @@ "XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,337.5,1.5,0.5,336.5,12.2,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",3.346952402,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,337.5,1.5,0.5,336.5,11.85937042,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",3.346952402,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",3,337.5,1.5,0.5,336.5,5.413133289,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 15",3.346952402,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,9.259674271,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,4.303346934,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",0,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",3,359.5,23.5,48,384,9.69,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,9.259674271,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",3,359.5,23.5,48,384,4.303346934,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 1 Day 16",9.34e-10,"ng/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.0011,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,503.18,-0.82,0,504,0.0011,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0.00055,"ug/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,503.18,-0.82,0,504,0,"Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,503.18,-0.82,0,504,0,"Metab. of Analyte01","intravascular",3.5,45,"M","WHITE",2.23,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",0,"ng/mL",0,"31/01/2022 13:42",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","10/01/2022 13:51",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",4,504.83,0.83,0,504,2.45,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",6.540739295,"ug/mL",0,"13/10/2021 12:55",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","06/10/2021 16:30",161,48.8,"kg","cm",0,"Sponsor123",11104 @@ -1871,14 +1871,14 @@ "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,505.53,1.53,0.5,504.5,12.1,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.24803501,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,505.53,1.53,0.5,504.5,11.58635242,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.24803501,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,505.53,1.53,0.5,504.5,5.481440212,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 1",3.24803501,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,8.329548693,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,3.913289621,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,531,27,48,552,5.929618595,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,531,27,48,552,2.539113296,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",0,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",4,529.5,25.5,48,552,8.88,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ug/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,8.329548693,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",4,529.5,25.5,48,552,3.913289621,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",1.26e-10,"ng/mL",0,"20/10/2021 15:10",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","13/10/2021 12:55",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",3,531,27,48,552,6.3,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",3,531,27,48,552,5.929618595,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",3,531,27,48,552,2.539113296,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 2",2.82e-11,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,671.13,-0.87,0,672,0.91,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.91,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,671.13,-0.87,0,672,0.91,"Metab. of Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.455,"ug/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,671.13,-0.87,0,672,0.412083557,"Analyte01","intravascular",2.15,45,"M","WHITE",1.6,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",0.412083557,"ng/mL",0,"07/02/2022 13:02",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","31/01/2022 13:42",188,90,"kg","cm",0,"Sponsor123",11106 @@ -1895,22 +1895,22 @@ "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,673.62,1.62,0.5,672.5,11.5,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.968480486,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,673.62,1.62,0.5,672.5,10.89343252,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.968480486,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,673.62,1.62,0.5,672.5,5.389411409,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 8",2.968480486,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,10.72193707,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,5.266087488,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,8.73558088,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,4.262302904,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,4.179376159,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,1.641646762,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,2.835053079,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,1.195996355,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",0,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,695.5,23.5,48,720,11.1,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,10.72193707,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,695.5,23.5,48,720,5.266087488,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",9.34e-10,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,698.53,26.53,48,720,9.39,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,8.73558088,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,698.53,26.53,48,720,4.262302904,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 9",4.51e-11,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",5,766.33,94.33,192,864,4.66,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ug/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,4.179376159,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",5,766.33,94.33,192,864,1.641646762,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.62e-40,"ng/mL",0,"27/10/2021 14:00",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","20/10/2021 15:10",161,48.8,"kg","cm",0,"Sponsor123",11104 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",4,768.47,96.47,192,864,3.32,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,2.835053079,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",4,768.47,96.47,192,864,1.195996355,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 12",1.9e-41,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",5,840.18,0.18,0,840,0.721,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",12.52905317,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",5,840.18,0.18,0,840,0.721,"Metab. of Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",12.52905317,"ug/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",5,840.18,0.18,0,840,0.197022986,"Analyte01","intravascular",35,45,"M","WHITE",1.12,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",12.52905317,"ng/mL",0,"14/02/2022 12:39",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","07/02/2022 13:02",188,90,"kg","cm",0,"Sponsor123",11106 @@ -1923,8 +1923,8 @@ "XX01","XX01-11104","Metab. of Analyte01","SERUM","EVERY WEEK",6,841.5,1.5,0.5,840.5,15.3,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.346952402,"ug/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Analyte01","CSF","EVERY WEEK",6,841.5,1.5,0.5,840.5,14.78576513,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.346952402,"ng/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 "XX01","XX01-11104","Metab. of Analyte01","CSF","EVERY WEEK",6,841.5,1.5,0.5,840.5,7.20730422,"Metab. of Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 2 Day 15",3.346952402,"ng/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 -"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 -"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Metab. of Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0118,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 +"XX01","XX01-11106","Metab. of Analyte01","SERUM","EVERY WEEK",6,1006.73,-1.27,0,1008,0.0118,"Metab. of Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0.0059,"ug/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Analyte01","CSF","EVERY WEEK",6,1006.73,-1.27,0,1008,0,"Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11106","Metab. of Analyte01","CSF","EVERY WEEK",6,1006.73,-1.27,0,1008,0,"Metab. of Analyte01","intravascular",1.17,45,"M","WHITE",0.07,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",0,"ng/mL",0,"21/02/2022 12:56",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","14/02/2022 12:39",188,90,"kg","cm",0,"Sponsor123",11106 "XX01","XX01-11104","Analyte01","SERUM","EVERY WEEK",7,1008.75,0.75,0,1008,2.35,"Analyte01","intravascular",35,57,"F","WHITE",0.5,"Hours","mg",0,"Analyte01","Cycle 3 Day 1",7.085498291,"ug/mL",0,"03/11/2021 12:35",339203,"Dummy Treatment Arm A","Dummy Treatment Arm P","27/10/2021 14:00",161,48.8,"kg","cm",0,"Sponsor123",11104 From 668b377c1af19c6f0e3034f2022fac2c3167c70a Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Mon, 20 Oct 2025 07:27:37 +0200 Subject: [PATCH 14/47] try change strategy BLQ --- R/PKNCA.R | 56 ++++++++++++++++++++++++++++++++----------------------- 1 file changed, 33 insertions(+), 23 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index daa631193..c943e119f 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -241,7 +241,6 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter data$options <- list( auc.method = method, - conc.blq = blq_imputation_rule, progress = FALSE, keep_interval_cols = c( "NCA_PROFILE", "DOSNOA", "type_interval", @@ -297,33 +296,44 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter ) %>% unique() - data$impute <- NA + data$impute <- "" # Impute start values if requested if (should_impute_c0) { data <- create_start_impute(data) - - # Don't impute parameters that are not AUC dependent - params_auc_dep <- metadata_nca_parameters %>% - filter(grepl("auc|aumc", PKNCA) | grepl("auc", Depends)) %>% - pull(PKNCA) - - params_not_to_impute <- metadata_nca_parameters %>% - filter(!grepl("auc|aumc", PKNCA), - !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% - pull(PKNCA) |> - intersect(names(PKNCA::get.interval.cols())) - - all_impute_methods <- na.omit(unique(data$intervals$impute)) - - data$intervals <- Reduce(function(d, ti_arg) { - interval_remove_impute( - d, - target_impute = ti_arg, - target_params = params_not_to_impute - ) - }, all_impute_methods, init = data$intervals) } +browser() + # Define a BLQ imputation method for PKNCA + PKNCA_impute_method_blq <- function(conc, time) { + PKNCA::clean.conc.blq(conc = conc, time = time, conc.blq = blq_imputation_rule) + } + data$intervals$impute <- "" + data$intervals$impute <- add_impute_method( + impute_vals = data$intervals$impute, + target_impute = "blq", + after = 0 + ) + + # Don't impute parameters that are not AUC dependent + params_auc_dep <- metadata_nca_parameters %>% + filter(grepl("auc|aumc", PKNCA) | grepl("auc", Depends)) %>% + pull(PKNCA) + + params_not_to_impute <- metadata_nca_parameters %>% + filter(!grepl("auc|aumc", PKNCA), + !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% + pull(PKNCA) |> + intersect(names(PKNCA::get.interval.cols())) + + all_impute_methods <- na.omit(unique(data$intervals$impute)) + + data$intervals <- Reduce(function(d, ti_arg) { + interval_remove_impute( + d, + target_impute = ti_arg, + target_params = params_not_to_impute + ) + }, all_impute_methods, init = data$intervals) data } From 6fdd4bcdd4d0889706281d71e89fcfda5d3de58a Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 22 Oct 2025 14:40:32 +0200 Subject: [PATCH 15/47] stage/stash --- R/PKNCA.R | 26 ++++++++++++++------------ R/create_start_impute.R | 4 ++-- R/intervals_helpers.R | 35 +++++++++++++++++++++++++++++++++++ 3 files changed, 51 insertions(+), 14 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index c943e119f..9be370ab1 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -296,29 +296,29 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter ) %>% unique() - data$impute <- "" + data$intervals$impute <- "" # Impute start values if requested if (should_impute_c0) { data <- create_start_impute(data) } -browser() + # Define a BLQ imputation method for PKNCA + data$intervals$impute <- ifelse( + data$intervals$impute != "", + paste("blq", data$intervals$impute, sep = ","), + "blq" + ) PKNCA_impute_method_blq <- function(conc, time) { PKNCA::clean.conc.blq(conc = conc, time = time, conc.blq = blq_imputation_rule) } - data$intervals$impute <- "" - data$intervals$impute <- add_impute_method( - impute_vals = data$intervals$impute, - target_impute = "blq", - after = 0 - ) # Don't impute parameters that are not AUC dependent params_auc_dep <- metadata_nca_parameters %>% - filter(grepl("auc|aumc", PKNCA) | grepl("auc", Depends)) %>% + filter((grepl("auc|aumc", PKNCA) | grepl("auc", Depends)), + TYPE == "PKNCA-not-covered") %>% pull(PKNCA) - + params_not_to_impute <- metadata_nca_parameters %>% filter(!grepl("auc|aumc", PKNCA), !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% @@ -326,14 +326,16 @@ browser() intersect(names(PKNCA::get.interval.cols())) all_impute_methods <- na.omit(unique(data$intervals$impute)) - +browser() + interval_remove_all_imputes(data = data$intervals, target_params = params_not_to_impute) %>% select(start, end, USUBJID, PARAM, cmax, auclast, vss.obs, impute) %>% View() + data$intervals <- Reduce(function(d, ti_arg) { interval_remove_impute( d, target_impute = ti_arg, target_params = params_not_to_impute ) - }, all_impute_methods, init = data$intervals) + }, sort(all_impute_methods), init = data$intervals) data } diff --git a/R/create_start_impute.R b/R/create_start_impute.R index b45c30675..bdb7895cb 100644 --- a/R/create_start_impute.R +++ b/R/create_start_impute.R @@ -76,8 +76,8 @@ create_start_impute <- function(pknca_data) { rowwise() %>% mutate( impute = case_when( - # Start concentration already present: No imputation (NA) - !!sym(time_column) == start & !is.na(!!sym(conc_column)) ~ NA, + # Start concentration already present: No imputation + !!sym(time_column) == start & !is.na(!!sym(conc_column)) ~ "", # 1st dose with not IV bolus or analyte =! drug : Start concentration is 0 is.first.dose & (!is.ivbolus | !is.analyte.drug) ~ "start_conc0", diff --git a/R/intervals_helpers.R b/R/intervals_helpers.R index f60d85c2a..b964e8d91 100644 --- a/R/intervals_helpers.R +++ b/R/intervals_helpers.R @@ -386,3 +386,38 @@ assert_subset <- function(a, b) { ) } } + + +interval_remove_all_imputes <- function(data, target_params) { + browser() + # Validate inputs + if (missing(data) || missing(target_params)) { + stop("Both 'data' and 'target_params' must be provided.") + } + + # Ensure the impute column exists and is a character column + if (!"impute" %in% colnames(data)) { + warning("No default impute column identified. No impute methods to remove") + return(data) + } else if (!is.character(data$impute)) { + stop("The 'impute' column in the intervals data.frame must be a character column.") + } + + # Get all parameter column names in the data frame + all_param_options <- setdiff(names(PKNCA::get.interval.cols()), c("start", "end")) + param_cols <- intersect(names(data), all_param_options) + + # Handle target_params + assert_subset(target_params, all_param_options) + + # Identify the interval rows that need to be changed + target_rows <- which(rowSums(replace(data[, target_params, drop = FALSE], + is.na(data[, target_params, drop = FALSE]), FALSE)) > 0) + new_rows <- data[target_rows, ] + new_rows[, setdiff(param_cols, target_params)] <- FALSE + new_rows$impute <- "" +browser() + data[target_rows, target_params] <- FALSE + bind_rows(data, new_rows) + +} From ab3ccdcb0bceb1c9ffe3531930f8293529aab243 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 4 Dec 2025 14:16:51 +0100 Subject: [PATCH 16/47] try: failing to include BLQ in impute --- R/PKNCA.R | 36 ++++++++++++++++++++++-------------- R/intervals_helpers.R | 3 +-- 2 files changed, 23 insertions(+), 16 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index cad20f5a8..414e3cef1 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -321,13 +321,19 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter ) }, all_impute_methods, init = data$intervals) } + all_impute_methods <- na.omit(unique(data$intervals$impute)) + + data$intervals <- Reduce(function(d, ti_arg) { + interval_remove_impute( + d, + target_impute = ti_arg, + target_params = params_not_to_impute + ) + }, sort(all_impute_methods), init = data$intervals) # Define a BLQ imputation method for PKNCA - data$intervals$impute <- ifelse( - data$intervals$impute != "", - paste("blq", data$intervals$impute, sep = ","), - "blq" - ) + # and apply it only for non-observational parameters + PKNCA_impute_method_blq <- function(conc, time) { PKNCA::clean.conc.blq(conc = conc, time = time, conc.blq = blq_imputation_rule) } @@ -344,17 +350,19 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter pull(PKNCA) |> intersect(names(PKNCA::get.interval.cols())) - all_impute_methods <- na.omit(unique(data$intervals$impute)) -browser() - interval_remove_all_imputes(data = data$intervals, target_params = params_not_to_impute) %>% select(start, end, USUBJID, PARAM, cmax, auclast, vss.obs, impute) %>% View() + params_to_impute <- setdiff(names(PKNCA::get.interval.cols()), c(params_not_to_impute, "start", "end")) - data$intervals <- Reduce(function(d, ti_arg) { - interval_remove_impute( - d, - target_impute = ti_arg, - target_params = params_not_to_impute + data$intervals <- data$intervals %>% + mutate( + param_to_impute_is_not_na = rowSums(!is.na(select(., all_of(params_to_impute)))) > 0, + param_to_impute_is_not_false = rowSums(select(., all_of(params_to_impute)) != FALSE, na.rm = TRUE) > 0, + has_param_to_impute = param_to_impute_is_not_na & param_to_impute_is_not_false, + impute = ifelse( + has_param_to_impute, + ifelse(is.na(impute) | impute == "", "blq", paste0("blq", impute, sep = ",")), + impute + ) ) - }, sort(all_impute_methods), init = data$intervals) data } diff --git a/R/intervals_helpers.R b/R/intervals_helpers.R index ae9de21c0..e61d005dc 100644 --- a/R/intervals_helpers.R +++ b/R/intervals_helpers.R @@ -389,7 +389,6 @@ assert_subset <- function(a, b) { interval_remove_all_imputes <- function(data, target_params) { - browser() # Validate inputs if (missing(data) || missing(target_params)) { stop("Both 'data' and 'target_params' must be provided.") @@ -416,7 +415,7 @@ interval_remove_all_imputes <- function(data, target_params) { new_rows <- data[target_rows, ] new_rows[, setdiff(param_cols, target_params)] <- FALSE new_rows$impute <- "" -browser() + data[target_rows, target_params] <- FALSE bind_rows(data, new_rows) From 7f72c3c468d3f82ea394530f72a95ce554ab4f4c Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 4 Dec 2025 15:41:23 +0100 Subject: [PATCH 17/47] stage --- R/PKNCA.R | 13 ++++++++----- 1 file changed, 8 insertions(+), 5 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index 414e3cef1..38b0a3e70 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -312,6 +312,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter intersect(names(PKNCA::get.interval.cols())) all_impute_methods <- na.omit(unique(data$intervals$impute)) + all_impute_methods <- all_impute_methods[all_impute_methods != ""] data$intervals <- Reduce(function(d, ti_arg) { interval_remove_impute( @@ -319,9 +320,9 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter target_impute = ti_arg, target_params = params_not_to_impute ) - }, all_impute_methods, init = data$intervals) + }, all_impute_methods, init = data$intervals) %>% + mutate(impute = ifelse(is.na(impute), "", impute)) } - all_impute_methods <- na.omit(unique(data$intervals$impute)) data$intervals <- Reduce(function(d, ti_arg) { interval_remove_impute( @@ -357,13 +358,15 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter param_to_impute_is_not_na = rowSums(!is.na(select(., all_of(params_to_impute)))) > 0, param_to_impute_is_not_false = rowSums(select(., all_of(params_to_impute)) != FALSE, na.rm = TRUE) > 0, has_param_to_impute = param_to_impute_is_not_na & param_to_impute_is_not_false, + impute = ifelse(is.na(impute), "", impute), impute = ifelse( has_param_to_impute, - ifelse(is.na(impute) | impute == "", "blq", paste0("blq", impute, sep = ",")), + ifelse(impute == "", "blq", paste0("blq, ", impute)), impute ) - ) - + ) %>% + select(any_of(names(data$intervals))) +browser() data } From 18b8f33b6c27d768419e5c83b4068ebf332caf75 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 4 Dec 2025 16:40:27 +0100 Subject: [PATCH 18/47] fix: test with expected "" instead of NA --- tests/testthat/test-create_start_impute.R | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/tests/testthat/test-create_start_impute.R b/tests/testthat/test-create_start_impute.R index a3beaa532..a5b2f9644 100644 --- a/tests/testthat/test-create_start_impute.R +++ b/tests/testthat/test-create_start_impute.R @@ -20,11 +20,11 @@ describe("create_start_impute", { expect_warning(create_start_impute(mydata_noints), "No intervals provided. No modification") }) - it("does not add impute (NA) when start is in PKNCAconc", { + it("does not add impute ('') when start is in PKNCAconc", { not_imputed <- result$intervals %>% dplyr::filter(USUBJID == 1, DOSNOA == 1, type_interval == "main") %>% dplyr::pull(impute) - expect_equal(not_imputed, NA_character_) + expect_equal(not_imputed, "") }) it("sets conc0 when route is extravascular (first dose)", { From 897a84e59189be019c6a5beee5b3f59492f6bb89 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Thu, 4 Dec 2025 16:43:41 +0100 Subject: [PATCH 19/47] try: simplify call of imputable params --- R/PKNCA.R | 12 ++---------- 1 file changed, 2 insertions(+), 10 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index 38b0a3e70..0af4c1481 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -340,19 +340,11 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter } # Don't impute parameters that are not AUC dependent - params_auc_dep <- metadata_nca_parameters %>% + params_to_impute <- metadata_nca_parameters %>% filter((grepl("auc|aumc", PKNCA) | grepl("auc", Depends)), - TYPE == "PKNCA-not-covered") %>% + TYPE != "PKNCA-not-covered") %>% pull(PKNCA) - params_not_to_impute <- metadata_nca_parameters %>% - filter(!grepl("auc|aumc", PKNCA), - !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% - pull(PKNCA) |> - intersect(names(PKNCA::get.interval.cols())) - - params_to_impute <- setdiff(names(PKNCA::get.interval.cols()), c(params_not_to_impute, "start", "end")) - data$intervals <- data$intervals %>% mutate( param_to_impute_is_not_na = rowSums(!is.na(select(., all_of(params_to_impute)))) > 0, From 9ae60bc9a020df7c73ed18b5f75ae5a8f49d7123 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Tue, 16 Dec 2025 14:24:47 +0100 Subject: [PATCH 20/47] fix: NA prevents issues ("") & use conc.group, time.group --- R/PKNCA.R | 11 ++++++----- 1 file changed, 6 insertions(+), 5 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index f67626204..6c998595b 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -334,9 +334,9 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter # Define a BLQ imputation method for PKNCA # and apply it only for non-observational parameters - - PKNCA_impute_method_blq <- function(conc, time) { - PKNCA::clean.conc.blq(conc = conc, time = time, conc.blq = blq_imputation_rule) + + PKNCA_impute_method_blq <<- function(conc.group, time.group, ...) { + PKNCA::clean.conc.blq(conc = conc.group, time = time.group, conc.blq = blq_imputation_rule) } # Don't impute parameters that are not AUC dependent @@ -355,10 +355,11 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter has_param_to_impute, ifelse(impute == "", "blq", paste0("blq, ", impute)), impute - ) + ), + impute = ifelse(impute == "", NA_character_, impute) ) %>% select(any_of(names(data$intervals))) -browser() + data } From 05641d6793cfc044c75f5312607b5030cbbea2f9 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Tue, 16 Dec 2025 14:43:44 +0100 Subject: [PATCH 21/47] refactor: lintr --- R/PKNCA.R | 6 ++++-- R/intervals_helpers.R | 2 +- inst/shiny/modules/tab_nca.R | 11 ----------- inst/shiny/modules/tab_nca/setup/data_imputation.R | 12 ++++++------ 4 files changed, 11 insertions(+), 20 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index 6c998595b..17ba431c3 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -335,7 +335,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter # Define a BLQ imputation method for PKNCA # and apply it only for non-observational parameters - PKNCA_impute_method_blq <<- function(conc.group, time.group, ...) { + PKNCA_impute_method_blq <<- function(conc.group, time.group, ...) { #nolint PKNCA::clean.conc.blq(conc = conc.group, time = time.group, conc.blq = blq_imputation_rule) } @@ -348,7 +348,9 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter data$intervals <- data$intervals %>% mutate( param_to_impute_is_not_na = rowSums(!is.na(select(., all_of(params_to_impute)))) > 0, - param_to_impute_is_not_false = rowSums(select(., all_of(params_to_impute)) != FALSE, na.rm = TRUE) > 0, + param_to_impute_is_not_false = rowSums( + select(., all_of(params_to_impute)) != FALSE, na.rm = TRUE + ) > 0, has_param_to_impute = param_to_impute_is_not_na & param_to_impute_is_not_false, impute = ifelse(is.na(impute), "", impute), impute = ifelse( diff --git a/R/intervals_helpers.R b/R/intervals_helpers.R index e61d005dc..17987783e 100644 --- a/R/intervals_helpers.R +++ b/R/intervals_helpers.R @@ -405,7 +405,7 @@ interval_remove_all_imputes <- function(data, target_params) { # Get all parameter column names in the data frame all_param_options <- setdiff(names(PKNCA::get.interval.cols()), c("start", "end")) param_cols <- intersect(names(data), all_param_options) - + # Handle target_params assert_subset(target_params, all_param_options) diff --git a/inst/shiny/modules/tab_nca.R b/inst/shiny/modules/tab_nca.R index cb5b73352..cbd861e8a 100644 --- a/inst/shiny/modules/tab_nca.R +++ b/inst/shiny/modules/tab_nca.R @@ -93,17 +93,6 @@ tab_nca_server <- function(id, pknca_data, extra_group_vars) { #' Triggers NCA analysis, creating res_nca reactive res_nca <- reactive({ req(processed_pknca_data()) -# # <<<<<<< HEAD -# -# withProgress(message = "Calculating NCA...", value = 0, { -# log_info("Calculating NCA results...") -# tryCatch({ -# # Create env for storing PKNCA run warnings, so that warning messages can be appended -# # from within warning handler without bleeding to global env. -# pknca_warn_env <- new.env() -# pknca_warn_env$warnings <- c() -# # ======= -# # >>>>>>> origin/main if (all(!unlist(processed_pknca_data()$intervals[sapply(processed_pknca_data()$intervals, is.logical)]))) { diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 72a0dbe78..1a7d56b4b 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -94,11 +94,11 @@ data_imputation_server <- function(id) { # Transform in the list text number to numeric rule_list <- lapply(rule_list, function(x) { if (x %in% c("drop", "keep")) { - return(x) + x } else if (grepl("^[0-9]+(\\.[0-9]+)?$", x)) { - return(as.numeric(x)) + as.numeric(x) } else { - return(NA) + NA } }) are_invalid_inputs <- is.na(unlist(rule_list)) @@ -115,10 +115,10 @@ data_imputation_server <- function(id) { rule_list }) - return(list( + list( should_impute_c0 = should_impute_c0, blq_imputation_rule = blq_rule - )) + ) }) } @@ -131,4 +131,4 @@ blq_selectize <- function(id, label, selected = NULL) { options = list(create = TRUE), width = "25%" ) -} \ No newline at end of file +} From 3fc8acd577422b3f360f44da56a051a1a34bdebc Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Tue, 16 Dec 2025 14:57:02 +0100 Subject: [PATCH 22/47] rm PR changes that are not needed --- R/PKNCA.R | 14 ++------------ R/intervals_helpers.R | 34 ---------------------------------- 2 files changed, 2 insertions(+), 46 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index 17ba431c3..0f50eff3c 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -294,7 +294,7 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter ) %>% unique() - data$intervals$impute <- "" + data$intervals$impute <- NA_character_ # Impute start values if requested if (should_impute_c0) { @@ -312,7 +312,6 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter intersect(names(PKNCA::get.interval.cols())) all_impute_methods <- na.omit(unique(data$intervals$impute)) - all_impute_methods <- all_impute_methods[all_impute_methods != ""] data$intervals <- Reduce(function(d, ti_arg) { interval_remove_impute( @@ -320,18 +319,9 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter target_impute = ti_arg, target_params = params_not_to_impute ) - }, all_impute_methods, init = data$intervals) %>% - mutate(impute = ifelse(is.na(impute), "", impute)) + }, all_impute_methods, init = data$intervals) } - data$intervals <- Reduce(function(d, ti_arg) { - interval_remove_impute( - d, - target_impute = ti_arg, - target_params = params_not_to_impute - ) - }, sort(all_impute_methods), init = data$intervals) - # Define a BLQ imputation method for PKNCA # and apply it only for non-observational parameters diff --git a/R/intervals_helpers.R b/R/intervals_helpers.R index 17987783e..f71b5f4b3 100644 --- a/R/intervals_helpers.R +++ b/R/intervals_helpers.R @@ -386,37 +386,3 @@ assert_subset <- function(a, b) { ) } } - - -interval_remove_all_imputes <- function(data, target_params) { - # Validate inputs - if (missing(data) || missing(target_params)) { - stop("Both 'data' and 'target_params' must be provided.") - } - - # Ensure the impute column exists and is a character column - if (!"impute" %in% colnames(data)) { - warning("No default impute column identified. No impute methods to remove") - return(data) - } else if (!is.character(data$impute)) { - stop("The 'impute' column in the intervals data.frame must be a character column.") - } - - # Get all parameter column names in the data frame - all_param_options <- setdiff(names(PKNCA::get.interval.cols()), c("start", "end")) - param_cols <- intersect(names(data), all_param_options) - - # Handle target_params - assert_subset(target_params, all_param_options) - - # Identify the interval rows that need to be changed - target_rows <- which(rowSums(replace(data[, target_params, drop = FALSE], - is.na(data[, target_params, drop = FALSE]), FALSE)) > 0) - new_rows <- data[target_rows, ] - new_rows[, setdiff(param_cols, target_params)] <- FALSE - new_rows$impute <- "" - - data[target_rows, target_params] <- FALSE - bind_rows(data, new_rows) - -} From f8e97de65759d3a00b237b27fa24ec563fe4fc8b Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Tue, 16 Dec 2025 15:21:36 +0100 Subject: [PATCH 23/47] test: fix expected NA (instead of "") --- tests/testthat/test-create_start_impute.R | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/tests/testthat/test-create_start_impute.R b/tests/testthat/test-create_start_impute.R index a5b2f9644..a3beaa532 100644 --- a/tests/testthat/test-create_start_impute.R +++ b/tests/testthat/test-create_start_impute.R @@ -20,11 +20,11 @@ describe("create_start_impute", { expect_warning(create_start_impute(mydata_noints), "No intervals provided. No modification") }) - it("does not add impute ('') when start is in PKNCAconc", { + it("does not add impute (NA) when start is in PKNCAconc", { not_imputed <- result$intervals %>% dplyr::filter(USUBJID == 1, DOSNOA == 1, type_interval == "main") %>% dplyr::pull(impute) - expect_equal(not_imputed, "") + expect_equal(not_imputed, NA_character_) }) it("sets conc0 when route is extravascular (first dose)", { From d626406421497b5c538323c970b058cd792def23 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Tue, 16 Dec 2025 15:26:05 +0100 Subject: [PATCH 24/47] add missing global bindings --- R/zzz.R | 5 +++++ 1 file changed, 5 insertions(+) diff --git a/R/zzz.R b/R/zzz.R index fe3eb577d..29341741e 100644 --- a/R/zzz.R +++ b/R/zzz.R @@ -58,6 +58,7 @@ "PCTPTNUM", "PCTPTREF", "PKNCA", + "PKNCA_impute_method_blq", "PPANMETH", "PPORRES", "PPORRESU", @@ -124,6 +125,7 @@ "exclude_half.life", "facet_title", "format_fun", + "has_param_to_impute", "id_list", "id_plot", "id_variable_col", @@ -132,6 +134,7 @@ "interval_name_col", "interval_next", "interval_prev", + "impute", "is.excluded.hl", "is.included.hl", "is.iv", @@ -153,6 +156,8 @@ "nom_dose_time", "nom_interval_next", "nom_interval_prev", + "param_to_impute_is_not_na", + "param_to_impute_is_not_false", "pknca_units_tbl", "ppanmeth_ref_groups", "ppanmeth_test_groups", From 7a17abd8b1fd4b044a36acfdda21a692a66dd624 Mon Sep 17 00:00:00 2001 From: =?UTF-8?q?Gerardo=20J=2E=20Rodr=C3=ADguez?= <68994823+Gero1999@users.noreply.github.com> Date: Wed, 31 Dec 2025 11:19:25 +0100 Subject: [PATCH 25/47] Apply style suggestions from code review MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Co-authored-by: Mateusz Kołomański <63905560+m-kolomanski@users.noreply.github.com> Co-authored-by: Copilot <175728472+Copilot@users.noreply.github.com> --- R/PKNCA.R | 7 ++----- inst/shiny/modules/tab_nca/setup/data_imputation.R | 5 ++--- 2 files changed, 4 insertions(+), 8 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index 0f50eff3c..7e365b511 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -229,7 +229,6 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter selected_pcspec, params, should_impute_c0 = TRUE, - # PKNCA default BLQ imputation rule blq_imputation_rule = list(first = "keep", middle = "drop", last = "keep") ) { @@ -337,10 +336,8 @@ PKNCA_update_data_object <- function( # nolint: object_name_linter data$intervals <- data$intervals %>% mutate( - param_to_impute_is_not_na = rowSums(!is.na(select(., all_of(params_to_impute)))) > 0, - param_to_impute_is_not_false = rowSums( - select(., all_of(params_to_impute)) != FALSE, na.rm = TRUE - ) > 0, + param_to_impute_is_not_na = if_any(all_of(params_to_impute), ~ !is.na(.)), + param_to_impute_is_not_false = if_any(all_of(params_to_impute), ~ !isFALSE(.)), has_param_to_impute = param_to_impute_is_not_na & param_to_impute_is_not_false, impute = ifelse(is.na(impute), "", impute), impute = ifelse( diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 1a7d56b4b..a56c43a85 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -10,8 +10,8 @@ data_imputation_ui <- function(id) { br(), helpText(HTML(paste( "Imputes a start-of-interval concentration to calculate non-observational parameters:", - "- If DOSNO = 1 & IV bolus: C0 = 0", - "- If DOSNO > 1 & not IV bolus: C0 = predose", + "- If first dose & IV bolus: C0 = 0", + "- If not first dose or not IV bolus: C0 = predose", "- If IV bolus & monoexponential data: logslope", "- If IV bolus & not monoexponential data: C0 = C1", sep = "
" @@ -29,7 +29,6 @@ data_imputation_ui <- function(id) { ), selected = "Tmax based imputation" ), - # Always render all inputs, but use conditionalPanel to show/hide div( style = "margin-top: 1em;", conditionalPanel( From 197db3bd15c019642fa066b79bbe18310543f3ae Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 31 Dec 2025 11:38:31 +0100 Subject: [PATCH 26/47] suggestion: don't asign reactive should_impute_c0 MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Co-authored-by: Mateusz Kołomański <63905560+m-kolomanski@users.noreply.github.com> --- inst/shiny/modules/tab_nca/setup/data_imputation.R | 6 +----- 1 file changed, 1 insertion(+), 5 deletions(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index a56c43a85..6ec8f5395 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -60,10 +60,6 @@ data_imputation_server <- function(id) { moduleServer(id, function(input, output, session) { ns <- session$ns - should_impute_c0 <- reactive({ - input$should_impute_c0 - }) - blq_rule <- reactive({ req(input$select_blq_strategy) rule_list <- switch( @@ -115,7 +111,7 @@ data_imputation_server <- function(id) { }) list( - should_impute_c0 = should_impute_c0, + should_impute_c0 = reactive(input$should_impute_c0), blq_imputation_rule = blq_rule ) }) From 1c20017885d7b6e5af8ec3f6386aa1d6ecb64cb2 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 31 Dec 2025 11:44:44 +0100 Subject: [PATCH 27/47] style: make equal name with return (blq_imputation_rule) --- inst/shiny/modules/tab_nca/setup/data_imputation.R | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 6ec8f5395..c764cf066 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -60,7 +60,7 @@ data_imputation_server <- function(id) { moduleServer(id, function(input, output, session) { ns <- session$ns - blq_rule <- reactive({ + blq_imputation_rule <- reactive({ req(input$select_blq_strategy) rule_list <- switch( input$select_blq_strategy, @@ -112,7 +112,7 @@ data_imputation_server <- function(id) { list( should_impute_c0 = reactive(input$should_impute_c0), - blq_imputation_rule = blq_rule + blq_imputation_rule = blq_imputation_rule ) }) } From 1c5d37d080835f2076e1d85e8abafe5b74629fe8 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 31 Dec 2025 13:29:32 +0100 Subject: [PATCH 28/47] change default BLQ imputation to no imputation --- R/intervals.R | 4 +++- inst/shiny/modules/tab_nca/setup/data_imputation.R | 2 +- 2 files changed, 4 insertions(+), 2 deletions(-) diff --git a/R/intervals.R b/R/intervals.R index 71612d057..45ab786fa 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -123,12 +123,14 @@ format_pkncadata_intervals <- function(pknca_conc, #' @param parameter_selections A named list of selected PKNCA parameters by study type. #' @param study_types_df A data frame mapping analysis profiles to their study type. #' @param auc_data A data frame containing partial AUC ranges. +#' @param blq_imputation_rule A list defining the BLQ imputation rule using PKNCA format. +#' Defaults to keeping all BLQ values without imputation. #' @param impute Logical indicating whether to impute start values for parameters. #' #' @returns An updated PKNCAdata object with parameter intervals based on user selections. #' update_main_intervals <- function(data, parameter_selections, - study_types_df, auc_data, impute = TRUE, blq_imputation_rule = list(first = "keep", middle = "drop", last = "keep")) { + study_types_df, auc_data, impute = TRUE, blq_imputation_rule = list(first = "keep", middle = "keep", last = "keep")) { all_pknca_params <- setdiff(names(PKNCA::get.interval.cols()), c("start", "end")) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index c764cf066..a4d9ea81c 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -100,7 +100,7 @@ data_imputation_server <- function(id) { if (any(are_invalid_inputs)) { showNotification( "BLQ imputation values must be numeric, 'drop' or 'keep'. - Otherwise, default PKNCA imputation (BLQ position) will be used", + Otherwise, no BLQ imputation will be applied.", type = "warning", duration = 8 ) From fbc290accf591ba934d7f953ea6707109b2fcddb Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 31 Dec 2025 16:16:49 +0100 Subject: [PATCH 29/47] refactor: define a fun to remove imputation methods --- R/intervals.R | 48 ++++++++++++++++++++---------------------------- 1 file changed, 20 insertions(+), 28 deletions(-) diff --git a/R/intervals.R b/R/intervals.R index 45ab786fa..0de4825aa 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -191,7 +191,7 @@ update_main_intervals <- function(data, parameter_selections, # Impute start values if requested if (impute) { - data <- apply_imputation(data) + data <- create_start_impute(data) } ############################################ @@ -202,27 +202,17 @@ update_main_intervals <- function(data, parameter_selections, PKNCA::clean.conc.blq(conc = conc.group, time = time.group, conc.blq = blq_imputation_rule) } - # Don't impute parameters that are not AUC dependent - params_to_impute <- metadata_nca_parameters %>% - filter((grepl("auc|aumc", PKNCA) | grepl("auc", Depends)), - TYPE != "PKNCA-not-covered") %>% - pull(PKNCA) - data$intervals <- data$intervals %>% mutate( - param_to_impute_is_not_na = if_any(all_of(params_to_impute), ~ !is.na(.)), - param_to_impute_is_not_false = if_any(all_of(params_to_impute), ~ !isFALSE(.)), - has_param_to_impute = param_to_impute_is_not_na & param_to_impute_is_not_false, - impute = ifelse(is.na(impute), "", impute), impute = ifelse( - has_param_to_impute, - ifelse(impute == "", "blq", paste0("blq, ", impute)), - impute - ), - impute = ifelse(impute == "", NA_character_, impute) - ) %>% - select(any_of(names(data$intervals))) - ############################################## + is.na(impute) | impute == "", + "blq", + paste0("blq, ", impute) + ) + ) + ############################################ + # Remove the + data <- rm_impute_obs_params(data, metadata_nca_parameters) data } @@ -237,22 +227,24 @@ update_main_intervals <- function(data, parameter_selections, #' @returns A PKNCAdata object with imputation rules applied. #' @import dplyr #' -apply_imputation <- function(data, nca_parameters = metadata_nca_parameters) { - data <- create_start_impute(data) - +rm_impute_obs_params <- function(data, metadata_nca_parameters = metadata_nca_parameters) { # Don't impute parameters that are not AUC dependent - params_auc_dep <- nca_parameters %>% + params_auc_dep <- metadata_nca_parameters %>% filter(grepl("auc|aumc", PKNCA) | grepl("auc", Depends)) %>% pull(PKNCA) - - params_not_to_impute <- nca_parameters %>% + + params_not_to_impute <- metadata_nca_parameters %>% filter(!grepl("auc|aumc", PKNCA), !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% pull(PKNCA) %>% intersect(names(PKNCA::get.interval.cols())) - - all_impute_methods <- na.omit(unique(data$intervals$impute)) - + + all_impute_methods <- na.omit(unique(data$intervals$impute)) %>% + strsplit(split = ",") %>% + unlist() %>% + trimws() %>% + unique() + data$intervals <- Reduce(function(d, ti_arg) { interval_remove_impute( d, From 0e75210a510e1e826bce7a3f15cc262a30787580 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 31 Dec 2025 16:21:11 +0100 Subject: [PATCH 30/47] refactor: lintr --- R/intervals.R | 66 +++++++++++++++++++++++++++++---------------------- 1 file changed, 38 insertions(+), 28 deletions(-) diff --git a/R/intervals.R b/R/intervals.R index 0de4825aa..234197fa2 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -53,8 +53,10 @@ format_pkncadata_intervals <- function(pknca_conc, dose_groups <- unname(unlist(pknca_dose$columns$groups)) time_column <- pknca_dose$columns$time # Obtain all possible pknca parameters - params <- setdiff(names(PKNCA::get.interval.cols()), - c("start", "end")) + params <- setdiff( + names(PKNCA::get.interval.cols()), + c("start", "end") + ) # Select conc data and for time column give priority to non-predose samples sub_pknca_conc <- pknca_conc$data %>% @@ -67,15 +69,17 @@ format_pkncadata_intervals <- function(pknca_conc, group_by(!!!syms(dose_groups)) %>% mutate(is_one_dose = length(unique(DOSNOA)) == 1) %>% ungroup() %>% - select(any_of(c(dose_groups, - time_column, "DOSNOA", "is_one_dose"))) + select(any_of(c( + dose_groups, + time_column, "DOSNOA", "is_one_dose" + ))) # Based on dose times create a data frame with start and end times dose_intervals <- left_join(sub_pknca_dose, - sub_pknca_conc, - by = intersect(names(sub_pknca_dose), c(conc_groups, "DOSNOA")), - relationship = "many-to-many") %>% - + sub_pknca_conc, + by = intersect(names(sub_pknca_dose), c(conc_groups, "DOSNOA")), + relationship = "many-to-many" + ) %>% # Pick 1 per concentration group and dose number group_by(!!!syms(dose_groups), DOSNOA) %>% mutate(max_end = max(ARRLT, na.rm = TRUE)) %>% # calculate max end time for Dose group @@ -83,13 +87,14 @@ format_pkncadata_intervals <- function(pknca_conc, group_by(!!!syms(c(conc_groups, "DOSNOA"))) %>% slice(1) %>% # slice one row per conc group ungroup() %>% - # Make start from last dose (pknca_dose) or first concentration (pknca_conc) - mutate(start = if (start_from_last_dose) !!sym(time_column) - else !!sym(time_column) + !!sym("ARRLT")) %>% + mutate(start = if (start_from_last_dose) { + !!sym(time_column) + } else { + !!sym(time_column) + !!sym("ARRLT") + }) %>% group_by(!!!syms(conc_groups)) %>% arrange(start) %>% - # Make end based on next dose time (if no more, TRTRINT or last NFRLT) mutate(end = if (has_trtrint) { case_when( @@ -104,17 +109,16 @@ format_pkncadata_intervals <- function(pknca_conc, is_one_dose ~ Inf, TRUE ~ start + max_end ) - } - ) %>% + }) %>% ungroup() %>% - select(any_of(c("start", "end", conc_groups, - "ATPTREF", "DOSNOA", "VOLUME"))) %>% - + select(any_of(c( + "start", "end", conc_groups, + "ATPTREF", "DOSNOA", "VOLUME" + ))) %>% # Create logical columns with only TRUE for the NCA parameters requested by the user mutate(!!!setNames(rep(FALSE, length(params)), params)) %>% # Identify the intervals as the base ones for the NCA analysis mutate(type_interval = "main") - } #' Update an intervals data frame with user-selected parameters by study type @@ -129,9 +133,13 @@ format_pkncadata_intervals <- function(pknca_conc, #' #' @returns An updated PKNCAdata object with parameter intervals based on user selections. #' -update_main_intervals <- function(data, parameter_selections, - study_types_df, auc_data, impute = TRUE, blq_imputation_rule = list(first = "keep", middle = "keep", last = "keep")) { - +update_main_intervals <- function( + data, + parameter_selections, + study_types_df, auc_data, + impute = TRUE, + blq_imputation_rule = list(first = "keep", middle = "keep", last = "keep") +) { all_pknca_params <- setdiff(names(PKNCA::get.interval.cols()), c("start", "end")) # Determine the grouping columns from the study_types_df @@ -198,7 +206,7 @@ update_main_intervals <- function(data, parameter_selections, # Define a BLQ imputation method for PKNCA # and apply it only for non-observational parameters - PKNCA_impute_method_blq <<- function(conc.group, time.group, ...) { #nolint + PKNCA_impute_method_blq <<- function(conc.group, time.group, ...) { # nolint PKNCA::clean.conc.blq(conc = conc.group, time = time.group, conc.blq = blq_imputation_rule) } @@ -211,7 +219,7 @@ update_main_intervals <- function(data, parameter_selections, ) ) ############################################ - # Remove the + # Remove any imputation from the observational parameters data <- rm_impute_obs_params(data, metadata_nca_parameters) data @@ -232,19 +240,21 @@ rm_impute_obs_params <- function(data, metadata_nca_parameters = metadata_nca_pa params_auc_dep <- metadata_nca_parameters %>% filter(grepl("auc|aumc", PKNCA) | grepl("auc", Depends)) %>% pull(PKNCA) - + params_not_to_impute <- metadata_nca_parameters %>% - filter(!grepl("auc|aumc", PKNCA), - !grepl(paste0(params_auc_dep, collapse = "|"), Depends)) %>% + filter( + !grepl("auc|aumc", PKNCA), + !grepl(paste0(params_auc_dep, collapse = "|"), Depends) + ) %>% pull(PKNCA) %>% intersect(names(PKNCA::get.interval.cols())) - + all_impute_methods <- na.omit(unique(data$intervals$impute)) %>% strsplit(split = ",") %>% unlist() %>% trimws() %>% unique() - + data$intervals <- Reduce(function(d, ti_arg) { interval_remove_impute( d, From 22b4425dbb7a3dd9025f2e32f564400bc0d8e408 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Wed, 31 Dec 2025 16:37:00 +0100 Subject: [PATCH 31/47] man: roxygenise --- man/{apply_imputation.Rd => rm_impute_obs_params.Rd} | 6 +++--- man/update_main_intervals.Rd | 6 +++++- 2 files changed, 8 insertions(+), 4 deletions(-) rename man/{apply_imputation.Rd => rm_impute_obs_params.Rd} (79%) diff --git a/man/apply_imputation.Rd b/man/rm_impute_obs_params.Rd similarity index 79% rename from man/apply_imputation.Rd rename to man/rm_impute_obs_params.Rd index bc5b9a6bf..965a293ce 100644 --- a/man/apply_imputation.Rd +++ b/man/rm_impute_obs_params.Rd @@ -1,10 +1,10 @@ % Generated by roxygen2: do not edit by hand % Please edit documentation in R/intervals.R -\name{apply_imputation} -\alias{apply_imputation} +\name{rm_impute_obs_params} +\alias{rm_impute_obs_params} \title{Apply Imputation for PKNCA Data} \usage{ -apply_imputation(data, nca_parameters = metadata_nca_parameters) +rm_impute_obs_params(data, metadata_nca_parameters = metadata_nca_parameters) } \arguments{ \item{data}{A PKNCAdata object.} diff --git a/man/update_main_intervals.Rd b/man/update_main_intervals.Rd index a17bd3f11..5a27d2724 100644 --- a/man/update_main_intervals.Rd +++ b/man/update_main_intervals.Rd @@ -9,7 +9,8 @@ update_main_intervals( parameter_selections, study_types_df, auc_data, - impute = TRUE + impute = TRUE, + blq_imputation_rule = list(first = "keep", middle = "keep", last = "keep") ) } \arguments{ @@ -22,6 +23,9 @@ update_main_intervals( \item{auc_data}{A data frame containing partial AUC ranges.} \item{impute}{Logical indicating whether to impute start values for parameters.} + +\item{blq_imputation_rule}{A list defining the BLQ imputation rule using PKNCA format. +Defaults to keeping all BLQ values without imputation.} } \value{ An updated PKNCAdata object with parameter intervals based on user selections. From 040f1063f1b0a3b83bd640183dc534669fa2113a Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 09:24:05 +0100 Subject: [PATCH 32/47] default blq_imputation_rule = NULL so tests do not have to be changed --- R/intervals.R | 31 +++++++++++++++++++------------ 1 file changed, 19 insertions(+), 12 deletions(-) diff --git a/R/intervals.R b/R/intervals.R index 234197fa2..dd8d65de2 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -138,7 +138,7 @@ update_main_intervals <- function( parameter_selections, study_types_df, auc_data, impute = TRUE, - blq_imputation_rule = list(first = "keep", middle = "keep", last = "keep") + blq_imputation_rule = NULL ) { all_pknca_params <- setdiff(names(PKNCA::get.interval.cols()), c("start", "end")) @@ -206,18 +206,21 @@ update_main_intervals <- function( # Define a BLQ imputation method for PKNCA # and apply it only for non-observational parameters - PKNCA_impute_method_blq <<- function(conc.group, time.group, ...) { # nolint - PKNCA::clean.conc.blq(conc = conc.group, time = time.group, conc.blq = blq_imputation_rule) - } + if (!is.null(blq_imputation_rule)) { + PKNCA_impute_method_blq <<- function(conc.group, time.group, ...) { # nolint + PKNCA::clean.conc.blq(conc = conc.group, time = time.group, conc.blq = blq_imputation_rule) + } - data$intervals <- data$intervals %>% - mutate( - impute = ifelse( - is.na(impute) | impute == "", - "blq", - paste0("blq, ", impute) + data$intervals <- data$intervals %>% + mutate( + impute = ifelse( + is.na(impute) | impute == "", + "blq", + paste0("blq, ", impute) + ) ) - ) + } + ############################################ # Remove any imputation from the observational parameters data <- rm_impute_obs_params(data, metadata_nca_parameters) @@ -249,7 +252,11 @@ rm_impute_obs_params <- function(data, metadata_nca_parameters = metadata_nca_pa pull(PKNCA) %>% intersect(names(PKNCA::get.interval.cols())) - all_impute_methods <- na.omit(unique(data$intervals$impute)) %>% + all_impute_methods <- na.omit(unique(data$intervals$impute)) + if (is.null(all_impute_methods)) { + return(data) + } + all_impute_methods <- all_impute_methods %>% strsplit(split = ",") %>% unlist() %>% trimws() %>% From 6c1b9f0f59c500a0c5b4828e52f70e86dbdeec9a Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 09:26:52 +0100 Subject: [PATCH 33/47] news: inform of BLQ imputation --- NEWS.md | 1 + 1 file changed, 1 insertion(+) diff --git a/NEWS.md b/NEWS.md index 5429d9f18..69423f491 100644 --- a/NEWS.md +++ b/NEWS.md @@ -11,6 +11,7 @@ * New Parameter Selection section in NCA tab allowing to select parameters by study type (#795) * The App optionally maps end of sample collection (AEFRLT) for excretion rate parameter calculations: ERTLST, ERTMAX. (#745) * Option to upload multiple input files, which will be bound together to form a single ADNCA data set (#821) +* BLQ imputation rules can be applied to the NCA via `NCA Setup > Data Imputation` ## Bugs fixed From 07f1a790e446527c34b5001487ec271cc86c206c Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 09:38:05 +0100 Subject: [PATCH 34/47] man: roxygenise --- man/update_main_intervals.Rd | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/man/update_main_intervals.Rd b/man/update_main_intervals.Rd index 5a27d2724..e4a2ddb7a 100644 --- a/man/update_main_intervals.Rd +++ b/man/update_main_intervals.Rd @@ -10,7 +10,7 @@ update_main_intervals( study_types_df, auc_data, impute = TRUE, - blq_imputation_rule = list(first = "keep", middle = "keep", last = "keep") + blq_imputation_rule = NULL ) } \arguments{ From ddd9f60aec165bb1a3533a8eda01f981f316c369 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 09:41:12 +0100 Subject: [PATCH 35/47] docs: change docs in rm_impute_obs_params() --- R/intervals.R | 3 ++- man/rm_impute_obs_params.Rd | 3 ++- 2 files changed, 4 insertions(+), 2 deletions(-) diff --git a/R/intervals.R b/R/intervals.R index dd8d65de2..0fe4b6057 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -234,7 +234,8 @@ update_main_intervals <- function( #' selectively removing imputation for parameters that are not dependent on AUC. #' #' @param data A PKNCAdata object. -#' @param nca_parameters A dataset containing the mapping between PKNCA terms and CDISC terms. +#' @param metadata_nca_parameters A dataset containing the mapping between PKNCA parameters (`PKNCA`) +#' and information on their parameter dependencies ('Depends'). #' @returns A PKNCAdata object with imputation rules applied. #' @import dplyr #' diff --git a/man/rm_impute_obs_params.Rd b/man/rm_impute_obs_params.Rd index 965a293ce..9cf0e450e 100644 --- a/man/rm_impute_obs_params.Rd +++ b/man/rm_impute_obs_params.Rd @@ -9,7 +9,8 @@ rm_impute_obs_params(data, metadata_nca_parameters = metadata_nca_parameters) \arguments{ \item{data}{A PKNCAdata object.} -\item{nca_parameters}{A dataset containing the mapping between PKNCA terms and CDISC terms.} +\item{metadata_nca_parameters}{A dataset containing the mapping between PKNCA parameters (\code{PKNCA}) +and information on their parameter dependencies ('Depends').} } \value{ A PKNCAdata object with imputation rules applied. From 049ac6cb749ae8eadfc1b1c70226f925a6099d0b Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 09:44:21 +0100 Subject: [PATCH 36/47] notification: refactor msg --- inst/shiny/modules/tab_nca/setup/data_imputation.R | 6 ++++-- 1 file changed, 4 insertions(+), 2 deletions(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index a4d9ea81c..604acb8d2 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -99,8 +99,10 @@ data_imputation_server <- function(id) { are_invalid_inputs <- is.na(unlist(rule_list)) if (any(are_invalid_inputs)) { showNotification( - "BLQ imputation values must be numeric, 'drop' or 'keep'. - Otherwise, no BLQ imputation will be applied.", + paste0( + "BLQ imputation values must be numeric, 'drop' or 'keep'. ", + "Otherwise, no BLQ imputation will be applied." + ), type = "warning", duration = 8 ) From 5f2dbf027e10608baa44dbcb7e4799e7c056fc23 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 10:33:03 +0100 Subject: [PATCH 37/47] refactor: lintr, roxygenise --- R/intervals.R | 2 +- man/rm_impute_obs_params.Rd | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/R/intervals.R b/R/intervals.R index 0fe4b6057..d66123bdf 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -234,7 +234,7 @@ update_main_intervals <- function( #' selectively removing imputation for parameters that are not dependent on AUC. #' #' @param data A PKNCAdata object. -#' @param metadata_nca_parameters A dataset containing the mapping between PKNCA parameters (`PKNCA`) +#' @param metadata_nca_parameters A data frame mapping PKNCA parameters (`PKNCA`) #' and information on their parameter dependencies ('Depends'). #' @returns A PKNCAdata object with imputation rules applied. #' @import dplyr diff --git a/man/rm_impute_obs_params.Rd b/man/rm_impute_obs_params.Rd index 9cf0e450e..467b347c7 100644 --- a/man/rm_impute_obs_params.Rd +++ b/man/rm_impute_obs_params.Rd @@ -9,7 +9,7 @@ rm_impute_obs_params(data, metadata_nca_parameters = metadata_nca_parameters) \arguments{ \item{data}{A PKNCAdata object.} -\item{metadata_nca_parameters}{A dataset containing the mapping between PKNCA parameters (\code{PKNCA}) +\item{metadata_nca_parameters}{A data frame mapping PKNCA parameters (\code{PKNCA}) and information on their parameter dependencies ('Depends').} } \value{ From 1e08be0e6df47bccb645bd0e4ec2cb4a7d989750 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 10:53:58 +0100 Subject: [PATCH 38/47] change docs & rm arg blq_imputation_rule from PKNCA.R --- R/PKNCA.R | 5 ----- R/intervals.R | 8 ++++++-- man/PKNCA_update_data_object.Rd | 6 ------ man/update_main_intervals.Rd | 8 ++++++-- 4 files changed, 12 insertions(+), 15 deletions(-) diff --git a/R/PKNCA.R b/R/PKNCA.R index 362e0808a..e828e9312 100644 --- a/R/PKNCA.R +++ b/R/PKNCA.R @@ -207,11 +207,6 @@ PKNCA_create_data_object <- function(adnca_data, nca_exclude_reason_columns = NU #' @param selected_profile User selected dose numbers/profiles #' @param selected_pcspec User selected specimen #' @param should_impute_c0 Logical indicating if start values should be imputed -#' @param blq_imputation_rule A list defining the BLQ imputation rule using PKNCA format. -#' The list should either contain three elements named: `first`, `middle`, and `last` or -#' two elements named `before.tmax` and `after.tmax`. Each element can be a numeric value -#' (substituting the BLQ value), or a string such as `"drop"` (ignores the value) -#' or `"keep"` (keeps the value as 0). #' #' @returns A fully configured `PKNCAdata` object. #' diff --git a/R/intervals.R b/R/intervals.R index d66123bdf..bdaf5bb3c 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -127,8 +127,12 @@ format_pkncadata_intervals <- function(pknca_conc, #' @param parameter_selections A named list of selected PKNCA parameters by study type. #' @param study_types_df A data frame mapping analysis profiles to their study type. #' @param auc_data A data frame containing partial AUC ranges. -#' @param blq_imputation_rule A list defining the BLQ imputation rule using PKNCA format. -#' Defaults to keeping all BLQ values without imputation. +#' @param blq_imputation_rule A list defining the Below Limit of Quantification (BLQ) +#' imputation rule using PKNCA format. The list should either contain three elements named: +#' `first`, `middle`, and `last` or two elements named `before.tmax` and `after.tmax`. +#' Each element can be a numeric value (substituting the BLQ value), or a string such as +#' `"drop"` (ignores the value) or `"keep"` (keeps the value as 0). Default is NULL, +#' which does not specify any BLQ imputation in any interval. #' @param impute Logical indicating whether to impute start values for parameters. #' #' @returns An updated PKNCAdata object with parameter intervals based on user selections. diff --git a/man/PKNCA_update_data_object.Rd b/man/PKNCA_update_data_object.Rd index 479774fd3..f4fddae79 100644 --- a/man/PKNCA_update_data_object.Rd +++ b/man/PKNCA_update_data_object.Rd @@ -25,12 +25,6 @@ PKNCA_update_data_object( \item{selected_pcspec}{User selected specimen} \item{should_impute_c0}{Logical indicating if start values should be imputed} - -\item{blq_imputation_rule}{A list defining the BLQ imputation rule using PKNCA format. -The list should either contain three elements named: \code{first}, \code{middle}, and \code{last} or -two elements named \code{before.tmax} and \code{after.tmax}. Each element can be a numeric value -(substituting the BLQ value), or a string such as \code{"drop"} (ignores the value) -or \code{"keep"} (keeps the value as 0).} } \value{ A fully configured \code{PKNCAdata} object. diff --git a/man/update_main_intervals.Rd b/man/update_main_intervals.Rd index e4a2ddb7a..83a6a89ec 100644 --- a/man/update_main_intervals.Rd +++ b/man/update_main_intervals.Rd @@ -24,8 +24,12 @@ update_main_intervals( \item{impute}{Logical indicating whether to impute start values for parameters.} -\item{blq_imputation_rule}{A list defining the BLQ imputation rule using PKNCA format. -Defaults to keeping all BLQ values without imputation.} +\item{blq_imputation_rule}{A list defining the Below Limit of Quantification (BLQ) +imputation rule using PKNCA format. The list should either contain three elements named: +\code{first}, \code{middle}, and \code{last} or two elements named \code{before.tmax} and \code{after.tmax}. +Each element can be a numeric value (substituting the BLQ value), or a string such as +\code{"drop"} (ignores the value) or \code{"keep"} (keeps the value as 0). Default is NULL, +which does not specify any BLQ imputation in any interval.} } \value{ An updated PKNCAdata object with parameter intervals based on user selections. From 2e466942b545e5cb50937138b858455835553711 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 11:02:23 +0100 Subject: [PATCH 39/47] refactor: lintr --- R/intervals.R | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/R/intervals.R b/R/intervals.R index bdaf5bb3c..55553b3ba 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -127,12 +127,12 @@ format_pkncadata_intervals <- function(pknca_conc, #' @param parameter_selections A named list of selected PKNCA parameters by study type. #' @param study_types_df A data frame mapping analysis profiles to their study type. #' @param auc_data A data frame containing partial AUC ranges. -#' @param blq_imputation_rule A list defining the Below Limit of Quantification (BLQ) -#' imputation rule using PKNCA format. The list should either contain three elements named: +#' @param blq_imputation_rule A list defining the Below Limit of Quantification (BLQ) +#' imputation rule using PKNCA format. The list should either contain three elements named: #' `first`, `middle`, and `last` or two elements named `before.tmax` and `after.tmax`. -#' Each element can be a numeric value (substituting the BLQ value), or a string such as +#' Each element can be a numeric value (substituting the BLQ value), or a string such as #' `"drop"` (ignores the value) or `"keep"` (keeps the value as 0). Default is NULL, -#' which does not specify any BLQ imputation in any interval. +#' which does not specify any BLQ imputation in any interval. #' @param impute Logical indicating whether to impute start values for parameters. #' #' @returns An updated PKNCAdata object with parameter intervals based on user selections. From 994008393142f608978e8f5486aa102f2084b753 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 11:13:45 +0100 Subject: [PATCH 40/47] don't require in slope_plots blq_imputation_rule --- inst/shiny/modules/tab_nca/setup.R | 6 ++++-- 1 file changed, 4 insertions(+), 2 deletions(-) diff --git a/inst/shiny/modules/tab_nca/setup.R b/inst/shiny/modules/tab_nca/setup.R index 030d6d110..5670772e8 100644 --- a/inst/shiny/modules/tab_nca/setup.R +++ b/inst/shiny/modules/tab_nca/setup.R @@ -160,8 +160,10 @@ setup_server <- function(id, data, adnca_data) { # Only parameters required for the slope plots are set in intervals # NCA dynamic changes/filters based on user selections slopes_pknca_data <- reactive({ - req(adnca_data(), settings(), settings()$profile, - settings()$analyte, settings()$pcspec, settings()$data_imputation$blq_imputation_rule) + req( + adnca_data(), settings(), settings()$profile, + settings()$analyte, settings()$pcspec + ) log_trace("Updating PKNCA::data object for slopes.") df <- PKNCA_update_data_object( From 5c49d11d60da93492cdcb95c40520059cd35b67c Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 11:14:45 +0100 Subject: [PATCH 41/47] english: correct comment grammar --- inst/shiny/modules/tab_nca/setup/data_imputation.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/inst/shiny/modules/tab_nca/setup/data_imputation.R b/inst/shiny/modules/tab_nca/setup/data_imputation.R index 604acb8d2..f8bbcdcae 100644 --- a/inst/shiny/modules/tab_nca/setup/data_imputation.R +++ b/inst/shiny/modules/tab_nca/setup/data_imputation.R @@ -86,7 +86,7 @@ data_imputation_server <- function(id) { NULL ) - # Transform in the list text number to numeric + # Transform text numbers in the list to numeric rule_list <- lapply(rule_list, function(x) { if (x %in% c("drop", "keep")) { x From b3ba671fae7af84d5c24c40de6f910a0c6f7c874 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 11:16:14 +0100 Subject: [PATCH 42/47] early NULL return use length()==0 --- R/intervals.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/R/intervals.R b/R/intervals.R index 55553b3ba..8f46cf3dc 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -258,7 +258,7 @@ rm_impute_obs_params <- function(data, metadata_nca_parameters = metadata_nca_pa intersect(names(PKNCA::get.interval.cols())) all_impute_methods <- na.omit(unique(data$intervals$impute)) - if (is.null(all_impute_methods)) { + if (length(all_impute_methods) == 0) { return(data) } all_impute_methods <- all_impute_methods %>% From 7e6ec735983078e61ed5a8f2d85e231caa00e0e8 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Fri, 2 Jan 2026 11:42:38 +0100 Subject: [PATCH 43/47] docs: just docs change order arg blq_imputation_rule --- R/intervals.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/R/intervals.R b/R/intervals.R index 8f46cf3dc..1fcc7256e 100644 --- a/R/intervals.R +++ b/R/intervals.R @@ -127,13 +127,13 @@ format_pkncadata_intervals <- function(pknca_conc, #' @param parameter_selections A named list of selected PKNCA parameters by study type. #' @param study_types_df A data frame mapping analysis profiles to their study type. #' @param auc_data A data frame containing partial AUC ranges. +#' @param impute Logical indicating whether to impute start values for parameters. #' @param blq_imputation_rule A list defining the Below Limit of Quantification (BLQ) #' imputation rule using PKNCA format. The list should either contain three elements named: #' `first`, `middle`, and `last` or two elements named `before.tmax` and `after.tmax`. #' Each element can be a numeric value (substituting the BLQ value), or a string such as #' `"drop"` (ignores the value) or `"keep"` (keeps the value as 0). Default is NULL, #' which does not specify any BLQ imputation in any interval. -#' @param impute Logical indicating whether to impute start values for parameters. #' #' @returns An updated PKNCAdata object with parameter intervals based on user selections. #' From 87163359c5db242cca9fc28e14f5fbbadeca71bb Mon Sep 17 00:00:00 2001 From: =?UTF-8?q?Gerardo=20J=2E=20Rodr=C3=ADguez?= <68994823+Gero1999@users.noreply.github.com> Date: Fri, 2 Jan 2026 12:17:49 +0100 Subject: [PATCH 44/47] Update NEWS.md Co-authored-by: Copilot <175728472+Copilot@users.noreply.github.com> --- NEWS.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/NEWS.md b/NEWS.md index 69423f491..72ded8653 100644 --- a/NEWS.md +++ b/NEWS.md @@ -11,7 +11,7 @@ * New Parameter Selection section in NCA tab allowing to select parameters by study type (#795) * The App optionally maps end of sample collection (AEFRLT) for excretion rate parameter calculations: ERTLST, ERTMAX. (#745) * Option to upload multiple input files, which will be bound together to form a single ADNCA data set (#821) -* BLQ imputation rules can be applied to the NCA via `NCA Setup > Data Imputation` +* BLQ imputation rules can be applied to the NCA via `NCA Setup > Data Imputation` (#139) ## Bugs fixed From 7cab9488c177580156867ec7a719ed669eac4088 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Mon, 5 Jan 2026 09:37:40 +0100 Subject: [PATCH 45/47] start drafting tests for blq_imputation_rule arg --- tests/testthat/test-intervals.R | 39 ++++++++++++++++++++++++++++++++- 1 file changed, 38 insertions(+), 1 deletion(-) diff --git a/tests/testthat/test-intervals.R b/tests/testthat/test-intervals.R index e3ba3f462..73f35318b 100644 --- a/tests/testthat/test-intervals.R +++ b/tests/testthat/test-intervals.R @@ -148,7 +148,6 @@ describe("format_pkncadata_intervals", { }) describe("update_main_intervals", { - all_pknca_params <- setdiff(names(PKNCA::get.interval.cols()), c("start", "end")) # setup data using FIXTURES @@ -271,4 +270,42 @@ describe("update_main_intervals", { "Missing required columns: PCSPEC") }) + it("applies blq_imputation_rule and sets impute column for BLQ", { + # Make 3 BLQ points for subject 1 + data$conc$data <- data$conc$data %>% + mutate(AVAL = ifelse( + USUBJID == unique(USUBJID)[1] & AFRLT %in% c(0, 2, 4), + 0, + AVAL + ) + ) + + # Keep the BLQ rows for subject 1 for testing + blq_rows_subj1 <- data$conc$data %>% + filter(USUBJID == unique(USUBJID)[1], AVAL == 0) + + # Only calculate one observational parameter and one imputable parameter + parameters <- list(`Single Extravascular Dose` = c("tmax", "aucinf.obs")) + auc_data <- tibble(start_auc = NA_real_, end_auc = NA_real_) + + # Test no BLQ imputation case + blq_rule_none <- NULL + data_no_blq_impute <- update_main_intervals(data, parameters, study_types_df, auc_data, blq_imputation_rule = blq_rule_none) + res_no_blq_impute <- PKNCA::pk.nca(data_no_blq_impute) + res_no_impute_blq <- res_no_blq_impute$result %>% + filter(USUBJID == unique(USUBJID)[1]) + + # Test when all BLQ points are kept; same as no imputation + blq_rule_all_keep <- list(first = "keep", middle = "keep", last = "keep") + data_blq_all_keep <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_all_keep) + res_all_keep_blq <- PKNCA::pk.nca(data_blq_all_keep) + res_all_keep_blq <- res_all_keep_blq$result %>% + filter(USUBJID == unique(USUBJID)[1]) + expect_equal(res_no_impute_blq, res_all_keep_blq) + + # Test that BLQ imputation affects lambda.z & aucinf.obs for after tmax calculations in extravascular doses + # while before tmax BLQ handling does only affect aucinf.obs + blq_rule_before_tmax <- list(before_tmax = 100, after_tmax = "keep") + blq_rule_after_tmax <- list(before_tmax = "keep", after_tmax = 100) + }) }) From 14c392a87494266def77fa01df15f300463cbdf0 Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Mon, 5 Jan 2026 11:09:54 +0100 Subject: [PATCH 46/47] finish tests for blq_imputation_rule --- tests/testthat/test-intervals.R | 60 ++++++++++++++++++++++++++++++--- 1 file changed, 55 insertions(+), 5 deletions(-) diff --git a/tests/testthat/test-intervals.R b/tests/testthat/test-intervals.R index 73f35318b..3602b6a46 100644 --- a/tests/testthat/test-intervals.R +++ b/tests/testthat/test-intervals.R @@ -285,7 +285,7 @@ describe("update_main_intervals", { filter(USUBJID == unique(USUBJID)[1], AVAL == 0) # Only calculate one observational parameter and one imputable parameter - parameters <- list(`Single Extravascular Dose` = c("tmax", "aucinf.obs")) + parameters <- list(`Single Extravascular Dose` = c("tmax", "auclast", "lambda.z")) auc_data <- tibble(start_auc = NA_real_, end_auc = NA_real_) # Test no BLQ imputation case @@ -293,19 +293,69 @@ describe("update_main_intervals", { data_no_blq_impute <- update_main_intervals(data, parameters, study_types_df, auc_data, blq_imputation_rule = blq_rule_none) res_no_blq_impute <- PKNCA::pk.nca(data_no_blq_impute) res_no_impute_blq <- res_no_blq_impute$result %>% - filter(USUBJID == unique(USUBJID)[1]) + filter(USUBJID == unique(USUBJID)[1]) %>% + unique() # Test when all BLQ points are kept; same as no imputation blq_rule_all_keep <- list(first = "keep", middle = "keep", last = "keep") data_blq_all_keep <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_all_keep) res_all_keep_blq <- PKNCA::pk.nca(data_blq_all_keep) res_all_keep_blq <- res_all_keep_blq$result %>% - filter(USUBJID == unique(USUBJID)[1]) + filter(USUBJID == unique(USUBJID)[1]) %>% + unique() expect_equal(res_no_impute_blq, res_all_keep_blq) # Test that BLQ imputation affects lambda.z & aucinf.obs for after tmax calculations in extravascular doses # while before tmax BLQ handling does only affect aucinf.obs - blq_rule_before_tmax <- list(before_tmax = 100, after_tmax = "keep") - blq_rule_after_tmax <- list(before_tmax = "keep", after_tmax = 100) + blq_rule_before_tmax <- list(before.tmax = 100, after.tmax = "keep") + blq_rule_after_tmax <- list(before.tmax = "keep", after.tmax = 100) + blq_rule_mixed_tmax <- list(before.tmax = 100, after.tmax = 100) + + data_blq_before_tmax <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_before_tmax) + res_blq_before_tmax <- PKNCA::pk.nca(data_blq_before_tmax) + res_blq_before_tmax <- res_blq_before_tmax$result %>% + filter(USUBJID == unique(USUBJID)[1]) %>% + unique() + expect_equal( + res_blq_before_tmax %>% filter(PPTESTCD == "auclast") %>% pull(PPORRES), + 99.66, + tolerance = 0.01 + ) + + data_blq_after_tmax <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_after_tmax) + res_blq_after_tmax <- PKNCA::pk.nca(data_blq_after_tmax) + res_blq_after_tmax <- res_blq_after_tmax$result %>% + filter(USUBJID == unique(USUBJID)[1]) %>% + unique() + expect_equal( + res_blq_after_tmax %>% filter(PPTESTCD == "auclast") %>% pull(PPORRES), + 56, + tolerance = 0.01 + ) + + data_blq_mixed_tmax <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_mixed_tmax) + res_blq_mixed_tmax <- PKNCA::pk.nca(data_blq_mixed_tmax) + res_blq_mixed_tmax <- res_blq_mixed_tmax$result %>% + filter(USUBJID == unique(USUBJID)[1]) %>% + unique() + expect_equal( + res_blq_mixed_tmax %>% filter(PPTESTCD == "auclast") %>% pull(PPORRES), + 151, + tolerance = 0.01 + ) + + # Test that indeed tmax (observational parameter) is unaffected by BLQ imputation + expect_equal( + res_blq_before_tmax %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), + res_no_impute_blq %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES) + ) + expect_equal( + res_blq_after_tmax %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), + res_no_impute_blq %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES) + ) + expect_equal( + res_blq_mixed_tmax %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), + res_no_impute_blq %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES) + ) }) }) From b3edf4f270ae685d74b7b7730b0dc88f141883fc Mon Sep 17 00:00:00 2001 From: Gero1999 Date: Mon, 5 Jan 2026 11:39:38 +0100 Subject: [PATCH 47/47] refactor: lintr --- tests/testthat/test-intervals.R | 265 ++++++++++++++++---------------- 1 file changed, 133 insertions(+), 132 deletions(-) diff --git a/tests/testthat/test-intervals.R b/tests/testthat/test-intervals.R index 3602b6a46..0b6948991 100644 --- a/tests/testthat/test-intervals.R +++ b/tests/testthat/test-intervals.R @@ -18,13 +18,19 @@ ADNCA <- data.frame( describe("format_pkncadata_intervals", { multi_analyte_adnca <- ADNCA %>% mutate(PARAM = rep(c("Analyte1", "Metabolite1"), each = 10)) df_conc <- format_pkncaconc_data(multi_analyte_adnca, - group_columns = c("STUDYID", "USUBJID", "PCSPEC", - "DOSETRT", "PARAM"), - time_column = "AFRLT") + group_columns = c( + "STUDYID", "USUBJID", "PCSPEC", + "DOSETRT", "PARAM" + ), + time_column = "AFRLT" + ) df_dose <- format_pkncadose_data(df_conc, - group_columns = c("STUDYID", "USUBJID", "PCSPEC", - "DOSETRT")) + group_columns = c( + "STUDYID", "USUBJID", "PCSPEC", + "DOSETRT" + ) + ) pknca_conc <- PKNCA::PKNCAconc( df_conc, @@ -48,15 +54,16 @@ describe("format_pkncadata_intervals", { expect_equal(result$tmax[1], FALSE) expect_equal(result$half.life[1], FALSE) expect_equal(result$cl.obs[1], FALSE) - }) it("handles incorrect input type", { expect_error(format_pkncadata_intervals(pknca_conc = df_conc, data.frame()), - regexp = "Input pknca_conc must be a PKNCAconc object from the PKNCA package.") + regexp = "Input pknca_conc must be a PKNCAconc object from the PKNCA package." + ) expect_error(format_pkncadata_intervals(pknca_conc = pknca_conc, data.frame()), - regexp = "Input pknca_dose must be a PKNCAdose object from the PKNCA package.") + regexp = "Input pknca_dose must be a PKNCAdose object from the PKNCA package." + ) }) it("handles missing columns", { @@ -73,7 +80,7 @@ describe("format_pkncadata_intervals", { it("correctly uses tau if column is available", { df_conc_tau <- df_conc %>% - mutate(TRTRINT = 5) # Add a tau column for testing + mutate(TRTRINT = 5) # Add a tau column for testing pknca_conc_tau <- PKNCA::PKNCAconc( df_conc_tau, @@ -95,30 +102,34 @@ describe("format_pkncadata_intervals", { it("sets end to Inf if no TRTRINT and single dose", { single_dose_pknca_conc <- pknca_conc single_dose_pknca_conc$data <- single_dose_pknca_conc$data %>% - filter(DOSNOA == 1) # Filter to a single dose + filter(DOSNOA == 1) # Filter to a single dose single_dose_pknca_dose <- pknca_dose single_dose_pknca_dose$data <- single_dose_pknca_dose$data %>% - filter(DOSNOA == 1) # Filter to a single dose + filter(DOSNOA == 1) # Filter to a single dose - result_single_dose <- format_pkncadata_intervals(single_dose_pknca_conc, - single_dose_pknca_dose) + result_single_dose <- format_pkncadata_intervals( + single_dose_pknca_conc, + single_dose_pknca_dose + ) expect_true(all(is.infinite(result_single_dose$end))) }) it("sets end to Inf if TRTRINT= NA and single dose", { single_dose_pknca_conc <- pknca_conc single_dose_pknca_conc$data <- single_dose_pknca_conc$data %>% - mutate(TRTRINT = NA) %>% # Set TRTRINT to NA - filter(DOSNOA == 1) # Filter to a single dose + mutate(TRTRINT = NA) %>% # Set TRTRINT to NA + filter(DOSNOA == 1) # Filter to a single dose single_dose_pknca_dose <- pknca_dose single_dose_pknca_dose$data <- single_dose_pknca_dose$data %>% - mutate(TRTRINT = NA) %>% # Set TRTRINT to NA - filter(DOSNOA == 1) # Filter to a single dose + mutate(TRTRINT = NA) %>% # Set TRTRINT to NA + filter(DOSNOA == 1) # Filter to a single dose - result_single_dose <- format_pkncadata_intervals(single_dose_pknca_conc, - single_dose_pknca_dose) + result_single_dose <- format_pkncadata_intervals( + single_dose_pknca_conc, + single_dose_pknca_dose + ) expect_true(all(is.infinite(result_single_dose$end))) }) @@ -129,10 +140,12 @@ describe("format_pkncadata_intervals", { pknca_dose_na_tau <- pknca_dose pknca_dose_na_tau$data <- pknca_dose$data %>% - mutate(TRTRINT = NA) # Set TRTRINT to NA + mutate(TRTRINT = NA) # Set TRTRINT to NA - result_single_dose <- format_pkncadata_intervals(pknca_conc_na_tau, - pknca_dose_na_tau) + result_single_dose <- format_pkncadata_intervals( + pknca_conc_na_tau, + pknca_dose_na_tau + ) expect_equal(result_single_dose$end[4], max(pknca_conc_na_tau$data$AFRLT, na.rm = TRUE)) }) @@ -144,36 +157,38 @@ describe("format_pkncadata_intervals", { ) expect_true(all(result$start >= 0)) }) - }) describe("update_main_intervals", { - all_pknca_params <- setdiff(names(PKNCA::get.interval.cols()), - c("start", "end")) + all_pknca_params <- setdiff( + names(PKNCA::get.interval.cols()), + c("start", "end") + ) # setup data using FIXTURES data <- FIXTURE_PKNCA_DATA data$intervals <- data$intervals %>% mutate(!!!setNames(rep(FALSE, length(all_pknca_params)), all_pknca_params), - PCSPEC = "SERUM", - STUDYID = "S1") %>% + PCSPEC = "SERUM", + STUDYID = "S1" + ) %>% filter(type_interval == "main") %>% select(-impute) - #create study types df + # create study types df study_types_df <- tribble( - ~STUDYID, ~DOSETRT, ~USUBJID, ~PCSPEC, ~ROUTE, ~type, - "S1", "A", 1, "SERUM", "extravascular", "Single Extravascular Dose", - "S1", "A", 2, "SERUM", "extravascular", "Multiple Extravascular Doses", - "S1", "A", 3, "SERUM", "intravascular", "Multiple IV Doses", - "S1", "A", 4, "SERUM", "intravascular", "Single IV Dose", - "S1", "A", 5, "SERUM", "intravascular", "Single IV Dose", - "S1", "A", 6, "SERUM", "intravascular", "Single IV Dose", - "S1", "A", 7, "SERUM", "intravascular", "Single IV Dose", - "S1", "A", 8, "SERUM", "extravascular", "Single Extravascular Dose", - "S1", "A", 8, "SERUM", "intravascular", "Multiple IV Doses" + ~STUDYID, ~DOSETRT, ~USUBJID, ~PCSPEC, ~ROUTE, ~type, + "S1", "A", 1, "SERUM", "extravascular", "Single Extravascular Dose", + "S1", "A", 2, "SERUM", "extravascular", "Multiple Extravascular Doses", + "S1", "A", 3, "SERUM", "intravascular", "Multiple IV Doses", + "S1", "A", 4, "SERUM", "intravascular", "Single IV Dose", + "S1", "A", 5, "SERUM", "intravascular", "Single IV Dose", + "S1", "A", 6, "SERUM", "intravascular", "Single IV Dose", + "S1", "A", 7, "SERUM", "intravascular", "Single IV Dose", + "S1", "A", 8, "SERUM", "extravascular", "Single Extravascular Dose", + "S1", "A", 8, "SERUM", "intravascular", "Multiple IV Doses" ) - #Create parameter list for each study type (one different per type) + # Create parameter list for each study type (one different per type) parameters <- list( `Single Extravascular Dose` = c("cmax", "tmax", "auclast"), `Multiple Extravascular Doses` = c("cmax", "tmax", "half.life"), @@ -185,7 +200,9 @@ describe("update_main_intervals", { it("correctly updates parameter flags based on study type", { result <- update_main_intervals(data, parameters, study_types_df, - auc_data, impute = FALSE) + auc_data, + impute = FALSE + ) # Check a specific profile: USUBJID 1 is 'Single Extravascular Dose' profile_1 <- result$intervals %>% filter(USUBJID == 1) @@ -205,7 +222,6 @@ describe("update_main_intervals", { }) it("handles partial AUCs (auc_data) creating proper intervals for each", { - auc_data <- data.frame( start_auc = c(0, 1, 2), end_auc = c(1, 2, 3) @@ -237,25 +253,31 @@ describe("update_main_intervals", { it("handles empty parameter selections and empty AUC data", { # Test with empty parameter list result_no_params <- update_main_intervals(data, list(), study_types_df, - auc_data, impute = FALSE) + auc_data, + impute = FALSE + ) param_flags <- result_no_params$intervals %>% select(all_of(all_pknca_params)) expect_true(all(param_flags == FALSE)) # Test with empty auc_data result_no_auc <- update_main_intervals(data, parameters, study_types_df, - auc_data, impute = FALSE) + auc_data, + impute = FALSE + ) expect_equal(nrow(result_no_auc$intervals), nrow(data$intervals)) }) it("filters out invalid AUC ranges before creating intervals", { invalid_auc_data <- data.frame( - start_auc = c(0, 5, -1, 2, NA), # valid, start > end, negative, start > end, NA - end_auc = c(4, 2, 1, 2, 4) + start_auc = c(0, 5, -1, 2, NA), # valid, start > end, negative, start > end, NA + end_auc = c(4, 2, 1, 2, 4) ) # Only first row is valid original_rows <- nrow(data$intervals) result <- update_main_intervals(data, parameters, study_types_df, - invalid_auc_data, impute = FALSE) + invalid_auc_data, + impute = FALSE + ) # Expect one new set of intervals for the single valid AUC range expect_equal(nrow(result$intervals), original_rows * 2) @@ -265,97 +287,76 @@ describe("update_main_intervals", { # remove PCSPEC column from intervals data$intervals$PCSPEC <- NULL - expect_error(update_main_intervals(data, parameters, study_types_df, - auc_data, impute = FALSE), - "Missing required columns: PCSPEC") + expect_error( + update_main_intervals(data, parameters, study_types_df, + auc_data, + impute = FALSE + ), + "Missing required columns: PCSPEC" + ) }) - it("applies blq_imputation_rule and sets impute column for BLQ", { - # Make 3 BLQ points for subject 1 + it("applies blq_imputation_rule only to non-observational parameters (refactored)", { + # --- Setup: Add BLQ (AVAL == 0) for subject 1 at times 0, 2, 4 --- + subj1 <- unique(data$conc$data$USUBJID)[1] + blq_times <- c(0, 2, 4) data$conc$data <- data$conc$data %>% - mutate(AVAL = ifelse( - USUBJID == unique(USUBJID)[1] & AFRLT %in% c(0, 2, 4), - 0, - AVAL - ) - ) - - # Keep the BLQ rows for subject 1 for testing - blq_rows_subj1 <- data$conc$data %>% - filter(USUBJID == unique(USUBJID)[1], AVAL == 0) - - # Only calculate one observational parameter and one imputable parameter - parameters <- list(`Single Extravascular Dose` = c("tmax", "auclast", "lambda.z")) - auc_data <- tibble(start_auc = NA_real_, end_auc = NA_real_) - - # Test no BLQ imputation case - blq_rule_none <- NULL - data_no_blq_impute <- update_main_intervals(data, parameters, study_types_df, auc_data, blq_imputation_rule = blq_rule_none) - res_no_blq_impute <- PKNCA::pk.nca(data_no_blq_impute) - res_no_impute_blq <- res_no_blq_impute$result %>% - filter(USUBJID == unique(USUBJID)[1]) %>% - unique() - - # Test when all BLQ points are kept; same as no imputation - blq_rule_all_keep <- list(first = "keep", middle = "keep", last = "keep") - data_blq_all_keep <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_all_keep) - res_all_keep_blq <- PKNCA::pk.nca(data_blq_all_keep) - res_all_keep_blq <- res_all_keep_blq$result %>% - filter(USUBJID == unique(USUBJID)[1]) %>% - unique() - expect_equal(res_no_impute_blq, res_all_keep_blq) - - # Test that BLQ imputation affects lambda.z & aucinf.obs for after tmax calculations in extravascular doses - # while before tmax BLQ handling does only affect aucinf.obs - blq_rule_before_tmax <- list(before.tmax = 100, after.tmax = "keep") - blq_rule_after_tmax <- list(before.tmax = "keep", after.tmax = 100) - blq_rule_mixed_tmax <- list(before.tmax = 100, after.tmax = 100) - - data_blq_before_tmax <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_before_tmax) - res_blq_before_tmax <- PKNCA::pk.nca(data_blq_before_tmax) - res_blq_before_tmax <- res_blq_before_tmax$result %>% - filter(USUBJID == unique(USUBJID)[1]) %>% - unique() - expect_equal( - res_blq_before_tmax %>% filter(PPTESTCD == "auclast") %>% pull(PPORRES), - 99.66, - tolerance = 0.01 + mutate(AVAL = ifelse(USUBJID == subj1 & AFRLT %in% blq_times, 0, AVAL)) %>% + filter(USUBJID == subj1) + data$intervals <- data$intervals %>% + filter(USUBJID == subj1) + study_types_df <- study_types_df %>% + filter(USUBJID == subj1) + + # For clarity, define subject and parameters + param_list <- list(`Single Extravascular Dose` = c("tmax", "auclast")) + auc_empty <- tibble(start_auc = NA_real_, end_auc = NA_real_) + + # --- Helper: Extract results for subject 1 --- + get_results <- function(data_obj) { + suppressWarnings(PKNCA::pk.nca(data_obj)$result) %>% unique() + } + + # --- 1. No BLQ imputation --- + no_blq <- update_main_intervals( + data, param_list, study_types_df, auc_empty, blq_imputation_rule = NULL ) + res_no_blq <- get_results(no_blq) - data_blq_after_tmax <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_after_tmax) - res_blq_after_tmax <- PKNCA::pk.nca(data_blq_after_tmax) - res_blq_after_tmax <- res_blq_after_tmax$result %>% - filter(USUBJID == unique(USUBJID)[1]) %>% - unique() - expect_equal( - res_blq_after_tmax %>% filter(PPTESTCD == "auclast") %>% pull(PPORRES), - 56, - tolerance = 0.01 - ) - - data_blq_mixed_tmax <- update_main_intervals(data, parameters, study_types_df, auc_data, impute = TRUE, blq_imputation_rule = blq_rule_mixed_tmax) - res_blq_mixed_tmax <- PKNCA::pk.nca(data_blq_mixed_tmax) - res_blq_mixed_tmax <- res_blq_mixed_tmax$result %>% - filter(USUBJID == unique(USUBJID)[1]) %>% - unique() - expect_equal( - res_blq_mixed_tmax %>% filter(PPTESTCD == "auclast") %>% pull(PPORRES), - 151, - tolerance = 0.01 - ) - - # Test that indeed tmax (observational parameter) is unaffected by BLQ imputation - expect_equal( - res_blq_before_tmax %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), - res_no_impute_blq %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES) - ) - expect_equal( - res_blq_after_tmax %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), - res_no_impute_blq %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES) - ) - expect_equal( - res_blq_mixed_tmax %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), - res_no_impute_blq %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES) + # --- 2. All BLQ points kept (should match no imputation) --- + blq_keep <- list(first = "keep", middle = "keep", last = "keep") + all_keep <- update_main_intervals( + data, param_list, study_types_df, auc_empty, impute = TRUE, blq_imputation_rule = blq_keep ) + res_all_keep <- get_results(all_keep) + expect_equal(res_no_blq, res_all_keep) + + # --- 3. BLQ imputation: before.tmax, after.tmax, and both --- + blq_before <- list(before.tmax = 100, after.tmax = "keep") + blq_after <- list(before.tmax = "keep", after.tmax = 100) + blq_both <- list(before.tmax = 100, after.tmax = 100) + + res_before <- get_results(update_main_intervals( + data, param_list, study_types_df, auc_empty, impute = TRUE, blq_imputation_rule = blq_before + )) + res_after <- get_results(update_main_intervals( + data, param_list, study_types_df, auc_empty, impute = TRUE, blq_imputation_rule = blq_after + )) + res_both <- get_results(update_main_intervals( + data, param_list, study_types_df, auc_empty, impute = TRUE, blq_imputation_rule = blq_both + )) + + # --- 4. Check that BLQ imputation affects only non-observational parameters --- + expect_equal(filter(res_before, PPTESTCD == "auclast") %>% pull(PPORRES), 99.6, tolerance = 0.1) + expect_equal(filter(res_after, PPTESTCD == "auclast") %>% pull(PPORRES), 56, tolerance = 0.1) + expect_equal(filter(res_both, PPTESTCD == "auclast") %>% pull(PPORRES), 151, tolerance = 0.1) + + # --- 5. tmax (observational) is unaffected by BLQ imputation --- + tmax_no_blq <- res_no_blq %>% + filter(PPTESTCD == "tmax") %>% + pull(PPORRES) + expect_equal(res_before %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), tmax_no_blq) + expect_equal(res_after %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), tmax_no_blq) + expect_equal(res_both %>% filter(PPTESTCD == "tmax") %>% pull(PPORRES), tmax_no_blq) }) })