Enhancement: BLQ imputation Options

[js3110]

Description

Option in the Data tab to allow the user to select which BLQ method should be applied to the dataset. The processed data is then used for NCA and for Plotting.

Suggested BLQ calculation options:

• Set BLQs before tmax to 0, and after tmax to Missing
• set the BLQ value to 1/2 of the lloq value.
• 1/3 Imputation rule

Make use of clean.conc.blq function in PKNCA

Definition of Done

The requirements for the feature to be complete:

• Option for user to select BLQ method, including option for None (ie BLQs already processed in data)
• If BLQ method chosen, Input options for User to define which column is LLOQ col, or to manually input LLOQ for each combination of PARAM, ASMED
• Data processed to mutate AVAL so that BLQs are processed in the chosen method.