diff --git a/tests/integration/test_issue_3003.py b/tests/integration/test_issue_3003.py
index 7c64ad7cc..53df5b9ab 100644
--- a/tests/integration/test_issue_3003.py
+++ b/tests/integration/test_issue_3003.py
@@ -14,9 +14,18 @@
 from pex.compatibility import commonpath
 from pex.interpreter import PythonInterpreter
 from pex.venv.virtualenv import Virtualenv
-from testing import run_pex_command
+from testing import make_env, run_pex_command
+from testing.cli import run_pex3
 from testing.pytest_utils.tmp import Tempdir
 
+OPEN_TELEMETRY_SEMANTIC_CONVENTIONS_BETA = "opentelemetry-semantic-conventions==0.59b0"
+
+
+@pytest.fixture
+def pex_root(tmpdir):
+    # type: (Tempdir) -> str
+    return tmpdir.join("pex-root")
+
 
 @pytest.fixture
 def project_dir(tmpdir):
@@ -37,9 +46,11 @@ def project_dir(tmpdir):
                 description = "Repro of issue 3003"
                 requires-python = "==3.10.*"
                 dependencies = [
-                    "opentelemetry-semantic-conventions==0.59b0",
+                    "{opentelemetry_requirement}",
                 ]
-                """
+                """.format(
+                    opentelemetry_requirement=OPEN_TELEMETRY_SEMANTIC_CONVENTIONS_BETA
+                )
             )
         )
     touch(os.path.join(project_dir, "src", "project", "__init__.py"))
@@ -77,15 +88,14 @@ def assert_opentelemetry_semconv(
     assert pex_root == commonpath((pex_root, output))
 
 
-def test_edge_case_semver_version_satisfied(
+def test_edge_case_semver_version_satisfied_venv_repository(
     tmpdir,  # type: Tempdir
-    project_dir,  # type: str
+    pex_root,  # type: str
     project_venv,  # type: Virtualenv
     py310,  # type: PythonInterpreter
 ):
     # type: (...) -> None
 
-    pex_root = tmpdir.join("pex-root")
     pex = tmpdir.join("project.pex")
     run_pex_command(
         args=[
@@ -146,7 +156,7 @@ def test_edge_case_semver_version_satisfied(
             "latest-compatible",
             "--venv-repository",
             project_venv.venv_dir,
-            "opentelemetry-semantic-conventions==0.59b0",
+            OPEN_TELEMETRY_SEMANTIC_CONVENTIONS_BETA,
             "-o",
             pex,
             "--no-compress",
@@ -154,3 +164,199 @@ def test_edge_case_semver_version_satisfied(
         python=project_venv.interpreter.binary,
     ).assert_success()
     assert_opentelemetry_semconv(python=py310, pex_root=pex_root, pex=pex)
+
+
+@pytest.fixture
+def pex_lock(
+    project_dir,  # type: str
+    pex_root,  # type: str
+    py310,  # type: PythonInterpreter
+):
+    # type: (...) -> str
+
+    lock = os.path.join(project_dir, "lock.json")
+    run_pex3(
+        "lock",
+        "create",
+        "--pex-root",
+        pex_root,
+        project_dir,
+        "--indent",
+        "2",
+        "-o",
+        lock,
+        python=py310.binary,
+    ).assert_success()
+    return lock
+
+
+@pytest.fixture
+def pylock_toml(
+    project_dir,  # type: str
+    pex_root,  # type: str
+    pex_lock,  # type: str
+    py310,  # type: PythonInterpreter
+):
+    # type: (...) -> str
+
+    pylock_toml = os.path.join(project_dir, "pylock.toml")
+    run_pex3(
+        "lock",
+        "export",
+        "--pex-root",
+        pex_root,
+        "--format",
+        "pep-751",
+        "-o",
+        pylock_toml,
+        pex_lock,
+        python=py310.binary,
+    ).assert_success()
+    return pylock_toml
+
+
+def test_edge_case_semver_version_satisfied_locks(
+    tmpdir,  # type: Tempdir
+    pex_root,  # type: str
+    pex_lock,  # type: str
+    pylock_toml,  # type: str
+    py310,  # type: PythonInterpreter
+):
+    # type: (...) -> None
+
+    pex = tmpdir.join("project.pex")
+    run_pex_command(
+        args=[
+            "--pex-root",
+            pex_root,
+            "--runtime-pex-root",
+            pex_root,
+            "--pylock",
+            pylock_toml,
+            OPEN_TELEMETRY_SEMANTIC_CONVENTIONS_BETA,
+            "-o",
+            pex,
+            "--no-compress",
+        ],
+        python=py310.binary,
+    ).assert_success()
+    assert_opentelemetry_semconv(python=py310, pex_root=pex_root, pex=pex)
+
+    run_pex_command(
+        args=[
+            "--pex-root",
+            pex_root,
+            "--runtime-pex-root",
+            pex_root,
+            "--lock",
+            pex_lock,
+            OPEN_TELEMETRY_SEMANTIC_CONVENTIONS_BETA,
+            "-o",
+            pex,
+            "--no-compress",
+        ],
+        python=py310.binary,
+    ).assert_success()
+    assert_opentelemetry_semconv(python=py310, pex_root=pex_root, pex=pex)
+
+
+@pytest.fixture
+def repository_pex(
+    tmpdir,  # type: Tempdir
+    pex_root,  # type: str
+    project_dir,  # type: str
+    py310,  # type: PythonInterpreter
+):
+    repository_pex = tmpdir.join("repository.pex")
+    run_pex_command(
+        args=[
+            "--pex-root",
+            pex_root,
+            "--runtime-pex-root",
+            pex_root,
+            "--include-tools",
+            project_dir,
+            "-o",
+            repository_pex,
+        ],
+        python=py310.binary,
+    ).assert_success()
+    return repository_pex
+
+
+@pytest.fixture
+def pre_resolved_dists(
+    tmpdir,  # type: Tempdir
+    pex_root,  # type: str
+    repository_pex,  # type: str
+    py310,  # type: PythonInterpreter
+):
+    # type: (...) -> str
+
+    pre_resolved_dists = tmpdir.join("pre-resolved-dists")
+    subprocess.check_call(
+        args=[
+            py310.binary,
+            repository_pex,
+            "repository",
+            "extract",
+            "--dest-dir",
+            pre_resolved_dists,
+        ],
+        env=make_env(PEX_TOOLS=1),
+    )
+    return pre_resolved_dists
+
+
+def test_edge_case_semver_version_satisfied_pex_repository(
+    tmpdir,  # type: Tempdir
+    pex_root,  # type: str
+    repository_pex,  # type: str
+    py310,  # type: PythonInterpreter
+):
+    # type: (...) -> None
+
+    pex = tmpdir.join("project.pex")
+    run_pex_command(
+        args=[
+            "--pex-root",
+            pex_root,
+            "--runtime-pex-root",
+            pex_root,
+            "--pex-repository",
+            repository_pex,
+            OPEN_TELEMETRY_SEMANTIC_CONVENTIONS_BETA,
+            "-o",
+            pex,
+            "--no-compress",
+        ],
+        python=py310.binary,
+    ).assert_success()
+    assert_opentelemetry_semconv(python=py310, pex_root=pex_root, pex=pex)
+
+
+def test_edge_case_semver_version_satisfied_pre_resolved_dists(
+    tmpdir,  # type: Tempdir
+    pex_root,  # type: str
+    pre_resolved_dists,  # type: str
+    py310,  # type: PythonInterpreter
+):
+    # type: (...) -> None
+
+    pex = tmpdir.join("project.pex")
+    run_pex_command(
+        args=[
+            "--pex-root",
+            pex_root,
+            "--runtime-pex-root",
+            pex_root,
+            "--pre-resolved-dists",
+            pre_resolved_dists,
+            OPEN_TELEMETRY_SEMANTIC_CONVENTIONS_BETA,
+            "-o",
+            pex,
+            "--no-compress",
+        ],
+        python=py310.binary,
+    ).assert_success()
+    assert_opentelemetry_semconv(python=py310, pex_root=pex_root, pex=pex)