diff --git a/src/macaron/build_spec_generator/build_spec_generator.py b/src/macaron/build_spec_generator/build_spec_generator.py
index 9d7fd94ca..e66be4ac2 100644
--- a/src/macaron/build_spec_generator/build_spec_generator.py
+++ b/src/macaron/build_spec_generator/build_spec_generator.py
@@ -98,8 +98,8 @@ def gen_build_spec_for_purl(
             case BuildSpecFormat.DOCKERFILE:
                 try:
                     build_spec_content = gen_dockerfile(build_spec)
-                except ValueError as error:
-                    logger.error("Error while serializing the build spec: %s.", error)
+                except GenerateBuildSpecError as error:
+                    logger.error("Error while generating the build spec: %s.", error)
                     return os.EX_DATAERR
                 build_spec_file_path = os.path.join(build_spec_dir_path, "dockerfile.buildspec")
 
diff --git a/src/macaron/build_spec_generator/common_spec/base_spec.py b/src/macaron/build_spec_generator/common_spec/base_spec.py
index c567609f7..698a0b948 100644
--- a/src/macaron/build_spec_generator/common_spec/base_spec.py
+++ b/src/macaron/build_spec_generator/common_spec/base_spec.py
@@ -1,4 +1,4 @@
-# Copyright (c) 2025 - 2025, Oracle and/or its affiliates. All rights reserved.
+# Copyright (c) 2025 - 2026, Oracle and/or its affiliates. All rights reserved.
 # Licensed under the Universal Permissive License v 1.0 as shown at https://oss.oracle.com/licenses/upl/.
 
 """This module includes base build specification and helper classes."""
@@ -81,6 +81,9 @@ class BaseBuildSpecDict(TypedDict, total=False):
     #: be a list of these that were used in building the wheel alongside their version.
     build_backends: NotRequired[list[str]]
 
+    #: Flag to indicate if the artifact includes binaries.
+    has_binaries: NotRequired[bool]
+
 
 class BaseBuildSpec(ABC):
     """Abstract base class for build specification behavior and field resolution."""
diff --git a/src/macaron/build_spec_generator/common_spec/core.py b/src/macaron/build_spec_generator/common_spec/core.py
index 26b2f329f..4c2cf1ecd 100644
--- a/src/macaron/build_spec_generator/common_spec/core.py
+++ b/src/macaron/build_spec_generator/common_spec/core.py
@@ -378,7 +378,7 @@ def gen_generic_build_spec(
             "purl": str(purl),
             "language": target_language,
             "build_tools": build_tool_names,
-            "build_commands": [selected_build_command],
+            "build_commands": [selected_build_command] if selected_build_command else [],
         }
     )
     ECOSYSTEMS[purl.type.upper()].value(base_build_spec_dict).resolve_fields(purl)
diff --git a/src/macaron/build_spec_generator/common_spec/pypi_spec.py b/src/macaron/build_spec_generator/common_spec/pypi_spec.py
index 999afbb19..7bdc023b6 100644
--- a/src/macaron/build_spec_generator/common_spec/pypi_spec.py
+++ b/src/macaron/build_spec_generator/common_spec/pypi_spec.py
@@ -1,4 +1,4 @@
-# Copyright (c) 2025 - 2025, Oracle and/or its affiliates. All rights reserved.
+# Copyright (c) 2025 - 2026, Oracle and/or its affiliates. All rights reserved.
 # Licensed under the Universal Permissive License v 1.0 as shown at https://oss.oracle.com/licenses/upl/.
 
 """This module includes build specification and helper classes for PyPI packages."""
@@ -17,7 +17,7 @@
 from macaron.build_spec_generator.build_command_patcher import CLI_COMMAND_PATCHES, patch_commands
 from macaron.build_spec_generator.common_spec.base_spec import BaseBuildSpec, BaseBuildSpecDict
 from macaron.config.defaults import defaults
-from macaron.errors import GenerateBuildSpecError, SourceCodeError
+from macaron.errors import GenerateBuildSpecError, SourceCodeError, WheelTagError
 from macaron.json_tools import json_extract
 from macaron.slsa_analyzer.package_registry import pypi_registry
 from macaron.slsa_analyzer.specs.package_registry_spec import PackageRegistryInfo
@@ -114,9 +114,9 @@ def resolve_fields(self, purl: PackageURL) -> None:
 
         pypi_package_json = pypi_registry.find_or_create_pypi_asset(purl.name, purl.version, registry_info)
         patched_build_commands: list[list[str]] = []
-        build_requires_set: set[str] = set()
         build_backends_set: set[str] = set()
         parsed_build_requires: dict[str, str] = {}
+        sdist_build_requires: dict[str, str] = {}
         python_version_set: set[str] = set()
         wheel_name_python_version_list: list[str] = []
         wheel_name_platforms: set[str] = set()
@@ -134,8 +134,16 @@ def resolve_fields(self, purl: PackageURL) -> None:
                         if py_version := json_extract(release, ["requires_python"], str):
                             python_version_set.add(py_version.replace(" ", ""))
 
+                self.data["has_binaries"] = not pypi_package_json.has_pure_wheel()
+
+                if self.data["has_binaries"]:
+                    logger.debug("Can not find a pure wheel")
+                else:
+                    logger.debug("Found pure wheel matching this PURL")
+
                 try:
-                    with pypi_package_json.wheel():
+                    # Argument called download_binaries
+                    with pypi_package_json.wheel(download_binaries=self.data["has_binaries"]):
                         logger.debug("Wheel at %s", pypi_package_json.wheel_path)
                         # Should only have .dist-info directory.
                         logger.debug("It has directories %s", ",".join(os.listdir(pypi_package_json.wheel_path)))
@@ -155,8 +163,20 @@ def resolve_fields(self, purl: PackageURL) -> None:
                         chronologically_likeliest_version = (
                             pypi_package_json.get_chronologically_suitable_setuptools_version()
                         )
+                        try:
+                            # Get information from the wheel file name.
+                            logger.debug(pypi_package_json.wheel_filename)
+                            _, _, _, tags = parse_wheel_filename(pypi_package_json.wheel_filename)
+                            for tag in tags:
+                                wheel_name_python_version_list.append(tag.interpreter)
+                                wheel_name_platforms.add(tag.platform)
+                            logger.debug(python_version_set)
+                        except InvalidWheelFilename:
+                            logger.debug("Could not parse wheel file name to extract version")
+                except WheelTagError:
+                    logger.debug("Can not analyze non-pure wheels")
                 except SourceCodeError:
-                    logger.debug("Could not find pure wheel matching this PURL")
+                    logger.debug("Could not download wheel matching this PURL")
 
                 logger.debug("From .dist_info:")
                 logger.debug(parsed_build_requires)
@@ -169,27 +189,32 @@ def resolve_fields(self, purl: PackageURL) -> None:
                             content = tomli.loads(pyproject_content.decode("utf-8"))
                             requires = json_extract(content, ["build-system", "requires"], list)
                             if requires:
-                                build_requires_set.update(elem.replace(" ", "") for elem in requires)
+                                for requirement in requires:
+                                    self.add_parsed_requirement(sdist_build_requires, requirement)
                             # If we cannot find `requires` in `[build-system]`, we lean on the fact that setuptools
                             # was the de-facto build tool, and infer a setuptools version to include.
                             else:
-                                build_requires_set.add(f"setuptools=={chronologically_likeliest_version}")
+                                self.add_parsed_requirement(
+                                    sdist_build_requires, f"setuptools=={chronologically_likeliest_version}"
+                                )
                             backend = json_extract(content, ["build-system", "build-backend"], str)
                             if backend:
                                 build_backends_set.add(backend.replace(" ", ""))
                             python_version_constraint = json_extract(content, ["project", "requires-python"], str)
                             if python_version_constraint:
                                 python_version_set.add(python_version_constraint.replace(" ", ""))
-                            self.apply_tool_specific_inferences(build_requires_set, python_version_set, content)
+                            self.apply_tool_specific_inferences(sdist_build_requires, python_version_set, content)
                             logger.debug(
                                 "After analyzing pyproject.toml from the sdist: build-requires: %s, build_backend: %s",
-                                build_requires_set,
+                                sdist_build_requires,
                                 build_backends_set,
                             )
                             # Here we have successfully analyzed the pyproject.toml file. Now, if we have a setup.py/cfg,
                             # we also need to infer a setuptools version to infer.
                             if pypi_package_json.file_exists("setup.py") or pypi_package_json.file_exists("setup.cfg"):
-                                build_requires_set.add(f"setuptools=={chronologically_likeliest_version}")
+                                self.add_parsed_requirement(
+                                    sdist_build_requires, f"setuptools=={chronologically_likeliest_version}"
+                                )
                         except TypeError as error:
                             logger.debug(
                                 "Found a type error while reading the pyproject.toml file from the sdist: %s", error
@@ -200,30 +225,20 @@ def resolve_fields(self, purl: PackageURL) -> None:
                             logger.debug("No pyproject.toml found: %s", error)
                             # Here we do not have a pyproject.toml file. Instead, we lean on the fact that setuptools
                             # was the de-facto build tool, and infer a setuptools version to include.
-                            build_requires_set.add(f"setuptools=={chronologically_likeliest_version}")
+                            self.add_parsed_requirement(
+                                sdist_build_requires, f"setuptools=={chronologically_likeliest_version}"
+                            )
                 except SourceCodeError as error:
                     logger.debug("No source distribution found: %s", error)
 
+                logger.debug("After complete analysis of the sdist:")
+                logger.debug(sdist_build_requires)
+
                 # Merge in pyproject.toml information only when the wheel dist_info does not contain the same.
                 # Hatch is an interesting example of this merge being required.
-                for requirement in build_requires_set:
-                    try:
-                        parsed_requirement = Requirement(requirement)
-                        if parsed_requirement.name not in parsed_build_requires:
-                            parsed_build_requires[parsed_requirement.name] = str(parsed_requirement.specifier)
-                    except (InvalidRequirement, InvalidSpecifier) as error:
-                        logger.debug("Malformed requirement encountered %s : %s", requirement, error)
-
-                try:
-                    # Get information from the wheel file name.
-                    logger.debug(pypi_package_json.wheel_filename)
-                    _, _, _, tags = parse_wheel_filename(pypi_package_json.wheel_filename)
-                    for tag in tags:
-                        wheel_name_python_version_list.append(tag.interpreter)
-                        wheel_name_platforms.add(tag.platform)
-                    logger.debug(python_version_set)
-                except InvalidWheelFilename:
-                    logger.debug("Could not parse wheel file name to extract version")
+                for requirement_name, specifier in sdist_build_requires.items():
+                    if requirement_name not in parsed_build_requires:
+                        parsed_build_requires[requirement_name] = specifier
 
                 self.data["language_version"] = list(python_version_set) or wheel_name_python_version_list
 
@@ -243,9 +258,18 @@ def resolve_fields(self, purl: PackageURL) -> None:
 
         if not patched_build_commands:
             # Resolve and patch build commands.
-            selected_build_commands = self.data["build_commands"] or self.get_default_build_commands(
-                self.data["build_tools"]
-            )
+
+            # To ensure that selected_build_commands is never empty, we seed with the fallback
+            # command of python -m build --wheel -n
+            if self.data["build_commands"]:
+                selected_build_commands = self.data["build_commands"]
+            else:
+                self.data["build_commands"] = ["python -m build --wheel -n".split()]
+                selected_build_commands = (
+                    self.get_default_build_commands(self.data["build_tools"]) or self.data["build_commands"]
+                )
+
+            logger.debug(selected_build_commands)
 
             patched_build_commands = (
                 patch_commands(
@@ -259,16 +283,34 @@ def resolve_fields(self, purl: PackageURL) -> None:
 
         self.data["build_commands"] = patched_build_commands
 
+    def add_parsed_requirement(self, build_requirements: dict[str, str], requirement: str) -> None:
+        """
+        Parse a requirement string and add it to build_requirements, doing appropriate error handling.
+
+        Parameters
+        ----------
+        build_requirements: dict[str,str]
+            Dictionary of build requirements to populate.
+        requirement: str
+            Requirement string to parse.
+        """
+        try:
+            parsed_requirement = Requirement(requirement)
+            if parsed_requirement.name not in build_requirements:
+                build_requirements[parsed_requirement.name] = str(parsed_requirement.specifier)
+        except (InvalidRequirement, InvalidSpecifier) as error:
+            logger.debug("Malformed requirement encountered %s : %s", requirement, error)
+
     def apply_tool_specific_inferences(
-        self, build_requires_set: set[str], python_version_set: set[str], pyproject_contents: dict[str, Any]
+        self, build_requirements: dict[str, str], python_version_set: set[str], pyproject_contents: dict[str, Any]
     ) -> None:
         """
         Based on build tools inferred, look into the pyproject.toml for related additional dependencies.
 
         Parameters
         ----------
-        build_requires_set: set[str]
-            Set of build requirements to populate.
+        build_requirements: dict[str,str]
+            Dictionary of build requirements to populate.
         python_version_set: set[str]
             Set of compatible interpreter versions to populate.
         pyproject_contents: dict[str, Any]
@@ -283,7 +325,8 @@ def apply_tool_specific_inferences(
                 for _, section in hatch_build_hooks.items():
                     dependencies = section.get("dependencies")
                     if dependencies:
-                        build_requires_set.update(elem.replace(" ", "") for elem in dependencies)
+                        for requirement in dependencies:
+                            self.add_parsed_requirement(build_requirements, requirement)
         # If we have flit as a build_tool, we will check if the legacy header [tool.flit.metadata] exists,
         # and if so, check to see if we can use its "requires-python".
         if "flit" in self.data["build_tools"]:
diff --git a/src/macaron/build_spec_generator/dockerfile/pypi_dockerfile_output.py b/src/macaron/build_spec_generator/dockerfile/pypi_dockerfile_output.py
index ef2360a5c..dd70da6f0 100644
--- a/src/macaron/build_spec_generator/dockerfile/pypi_dockerfile_output.py
+++ b/src/macaron/build_spec_generator/dockerfile/pypi_dockerfile_output.py
@@ -1,9 +1,10 @@
-# Copyright (c) 2025 - 2025, Oracle and/or its affiliates. All rights reserved.
+# Copyright (c) 2025 - 2026, Oracle and/or its affiliates. All rights reserved.
 # Licensed under the Universal Permissive License v 1.0 as shown at https://oss.oracle.com/licenses/upl/.
 
 """This module implements the logic to generate a dockerfile from a Python buildspec."""
 
 import logging
+import re
 from textwrap import dedent
 
 from packaging.specifiers import InvalidSpecifier, SpecifierSet
@@ -33,10 +34,11 @@ def gen_dockerfile(buildspec: BaseBuildSpecDict) -> str:
     GenerateBuildSpecError
         Raised if dockerfile cannot be generated.
     """
+    if buildspec["has_binaries"]:
+        raise GenerateBuildSpecError("We currently do not support generating a dockerfile for non-pure Python packages")
     language_version: str | None = pick_specific_version(buildspec)
     if language_version is None:
-        logger.debug("Could not derive a specific interpreter version.")
-        raise GenerateBuildSpecError("Could not derive specific interpreter version.")
+        raise GenerateBuildSpecError("Could not derive specific interpreter version")
     backend_install_commands: str = " && ".join(build_backend_commands(buildspec))
     build_tool_install: str = ""
     if (
@@ -124,8 +126,18 @@ def pick_specific_version(buildspec: BaseBuildSpecDict) -> str | None:
         try:
             version_set &= SpecifierSet(version)
         except InvalidSpecifier as error:
-            logger.debug("Malformed interpreter version encountered: %s (%s)", version, error)
-            return None
+            logger.debug("Non-standard interpreter version encountered: %s (%s)", version, error)
+            # Whilst the Python tags specify interpreter implementation
+            # as well as version, with no standard way to parse out the
+            # implementation, we can attempt to heuristically:
+            try_parse_version = infer_interpreter_version(version)
+            if try_parse_version:
+                try:
+                    version_set &= SpecifierSet(f">={try_parse_version}")
+                except InvalidSpecifier as error_for_retry:
+                    logger.debug("Could not parse interpreter version from: %s (%s)", version, error_for_retry)
+
+    logger.debug(version_set)
 
     # Now to get the latest acceptable one, we can step through all interpreter
     # versions. For the most accurate result, we can query python.org for a
@@ -141,6 +153,31 @@ def pick_specific_version(buildspec: BaseBuildSpecDict) -> str | None:
     return None
 
 
+def infer_interpreter_version(tag: str) -> str | None:
+    """Infer interpreter version from Python-tag.
+
+    Parameters
+    ----------
+    tag: Python-tag, likely inferred from wheel name.
+
+
+    Returns
+    -------
+    str: interpreter version inferred from Python-tag
+    """
+    # We will parse the interpreter version of CPython or just
+    # whatever generic Python version is specified.
+    pattern = re.compile(r"^(py|cp)(\d{1,3})$")
+    parsed_tag = pattern.match(tag)
+    if parsed_tag:
+        digits = parsed_tag.group(2)
+        # As match succeeded len(digits) \in {1,2,3}
+        if len(digits) == 1:
+            return parsed_tag.group(2)
+        return f"{digits[0]}.{digits[1:]}"
+    return None
+
+
 def build_backend_commands(buildspec: BaseBuildSpecDict) -> list[str]:
     """Generate the installation commands for each inferred build backend.
 
diff --git a/src/macaron/errors.py b/src/macaron/errors.py
index d088914de..569ec1817 100644
--- a/src/macaron/errors.py
+++ b/src/macaron/errors.py
@@ -1,4 +1,4 @@
-# Copyright (c) 2023 - 2025, Oracle and/or its affiliates. All rights reserved.
+# Copyright (c) 2023 - 2026, Oracle and/or its affiliates. All rights reserved.
 # Licensed under the Universal Permissive License v 1.0 as shown at https://oss.oracle.com/licenses/upl/.
 
 """This module contains error classes for Macaron."""
@@ -129,3 +129,7 @@ class QueryMacaronDatabaseError(Exception):
 
 class GenerateBuildSpecError(Exception):
     """Happens when there is an unexpected error while generating the build spec file."""
+
+
+class WheelTagError(MacaronError):
+    """Happens when a Python wheel with unsupported tags is requested for analysis."""
diff --git a/src/macaron/slsa_analyzer/package_registry/pypi_registry.py b/src/macaron/slsa_analyzer/package_registry/pypi_registry.py
index ce8630d37..ce278b35c 100644
--- a/src/macaron/slsa_analyzer/package_registry/pypi_registry.py
+++ b/src/macaron/slsa_analyzer/package_registry/pypi_registry.py
@@ -1,4 +1,4 @@
-# Copyright (c) 2023 - 2025, Oracle and/or its affiliates. All rights reserved.
+# Copyright (c) 2023 - 2026, Oracle and/or its affiliates. All rights reserved.
 # Licensed under the Universal Permissive License v 1.0 as shown at https://oss.oracle.com/licenses/upl/.
 
 """The module provides abstractions for the pypi package registry."""
@@ -22,9 +22,10 @@
 
 import requests
 from bs4 import BeautifulSoup, Tag
+from packaging.utils import InvalidWheelFilename, parse_wheel_filename
 
 from macaron.config.defaults import defaults
-from macaron.errors import ConfigurationError, InvalidHTTPResponseError, SourceCodeError
+from macaron.errors import ConfigurationError, InvalidHTTPResponseError, SourceCodeError, WheelTagError
 from macaron.json_tools import json_extract
 from macaron.malware_analyzer.datetime_parser import parse_datetime
 from macaron.slsa_analyzer.package_registry.package_registry import PackageRegistry
@@ -863,8 +864,10 @@ def get_latest_release_upload_time(self) -> str | None:
         return None
 
     @contextmanager
-    def wheel(self) -> Generator[None]:
+    def wheel(self, download_binaries: bool) -> Generator[None]:
         """Download and cleanup wheel of the package with a context manager."""
+        if download_binaries:
+            raise WheelTagError("Macaron does not currently support analysis of non-pure Python wheels.")
         if not self.download_wheel():
             raise SourceCodeError("Unable to download requested wheel.")
         yield
@@ -889,6 +892,38 @@ def download_wheel(self) -> bool:
                 logger.debug(error)
         return False
 
+    def has_pure_wheel(self) -> bool:
+        """Check whether the PURL has a pure wheel from its package json.
+
+        Returns
+        -------
+        bool
+            Whether the PURL has a pure wheel or not.
+        """
+        if self.component_version:
+            urls = json_extract(self.package_json, ["releases", self.component_version], list)
+        else:
+            # Get the latest version.
+            urls = json_extract(self.package_json, ["urls"], list)
+        if not urls:
+            return False
+        for distribution in urls:
+            file_name: str = distribution.get("filename") or ""
+            # Parse out and check none and any
+            # Catch exceptions
+            try:
+                _, _, _, tags = parse_wheel_filename(file_name)
+                # Check if none and any are in the tags (i.e. the wheel is pure)
+                # Technically a wheel can have multiple tag sets. Our condition for
+                # a pure wheel is that it has only one tag set with abi "none" and
+                # platform "any"
+                if len(tags) == 1 and all(tag.abi == "none" and tag.platform == "any" for tag in tags):
+                    return True
+            except InvalidWheelFilename:
+                logger.debug("Could not parse wheel name.")
+                return False
+        return False
+
     @contextmanager
     def sourcecode(self) -> Generator[None]:
         """Download and cleanup source code of the package with a context manager."""
diff --git a/tests/build_spec_generator/dockerfile/test_pypi_dockerfile_output.py b/tests/build_spec_generator/dockerfile/test_pypi_dockerfile_output.py
index b62ea049a..c8d4d8882 100644
--- a/tests/build_spec_generator/dockerfile/test_pypi_dockerfile_output.py
+++ b/tests/build_spec_generator/dockerfile/test_pypi_dockerfile_output.py
@@ -1,4 +1,4 @@
-# Copyright (c) 2025 - 2025, Oracle and/or its affiliates. All rights reserved.
+# Copyright (c) 2025 - 2026, Oracle and/or its affiliates. All rights reserved.
 # Licensed under the Universal Permissive License v 1.0 as shown at https://oss.oracle.com/licenses/upl/.
 
 """
@@ -27,6 +27,7 @@ def fixture_base_build_spec() -> BaseBuildSpecDict:
             "ecosystem": "pypi",
             "purl": "pkg:pypi/cachetools@6.2.1",
             "language": "python",
+            "has_binaries": False,
             "build_tools": ["pip"],
             "build_commands": [["python", "-m", "build"]],
             "build_requires": {"setuptools": "==80.9.0", "wheel": ""},
diff --git a/tests/integration/cases/pypi_cachetools/expected_default.buildspec b/tests/integration/cases/pypi_cachetools/expected_default.buildspec
index 0b5d8acfa..2a05c0e95 100644
--- a/tests/integration/cases/pypi_cachetools/expected_default.buildspec
+++ b/tests/integration/cases/pypi_cachetools/expected_default.buildspec
@@ -1,5 +1,5 @@
 {
-    "macaron_version": "0.18.0",
+    "macaron_version": "0.20.0",
     "group_id": null,
     "artifact_id": "cachetools",
     "version": "6.2.1",
@@ -24,6 +24,7 @@
             "-n"
         ]
     ],
+    "has_binaries": false,
     "build_requires": {
         "setuptools": "==80.9.0",
         "wheel": ""
diff --git a/tests/integration/cases/pypi_markdown-it-py/expected_default.buildspec b/tests/integration/cases/pypi_markdown-it-py/expected_default.buildspec
index e7842d046..e610ee866 100644
--- a/tests/integration/cases/pypi_markdown-it-py/expected_default.buildspec
+++ b/tests/integration/cases/pypi_markdown-it-py/expected_default.buildspec
@@ -1,5 +1,5 @@
 {
-    "macaron_version": "0.18.0",
+    "macaron_version": "0.20.0",
     "group_id": null,
     "artifact_id": "markdown-it-py",
     "version": "4.0.0",
@@ -21,6 +21,7 @@
             "build"
         ]
     ],
+    "has_binaries": false,
     "build_requires": {
         "flit": "==3.12.0",
         "flit_core": "<4,>=3.4"
diff --git a/tests/integration/cases/pypi_toga/expected_default.buildspec b/tests/integration/cases/pypi_toga/expected_default.buildspec
index 819113207..875523655 100644
--- a/tests/integration/cases/pypi_toga/expected_default.buildspec
+++ b/tests/integration/cases/pypi_toga/expected_default.buildspec
@@ -24,6 +24,7 @@
             "-n"
         ]
     ],
+    "has_binaries": false,
     "build_requires": {
         "setuptools": "==80.3.1",
         "setuptools_dynamic_dependencies": "==1.0.0",