"carotid body" should not be part of the cardiovascular system

[sabrinatoro]

Uberon term
UBERON:0001629
carotid body

Suggested revision and reasons

The current parentage of this term indicate that it is part of "common carotid artery plus branches" (UBERON:0001530), which is incorrect.

According to PMID:32965908, and according to the current definition, "carotid body is a sensory organ in the peripheral nervous system located in the adventitia of the bifurcation of the common carotid artery".
While the structure is "adjacent to", it is not "part of: the "common carotid artery plus branches"

According to the information above, this term should be part of the peripheral nervous system.

[cmungall]

@dragon-ai-agent please fix this.

[dragon-ai-agent]

Issue Fixed ✅

I have successfully reclassified the carotid body (UBERON:0001629) to correctly place it within the peripheral nervous system rather than the cardiovascular system.

Changes Made:

• Relationship corrected: Removed
• New relationship: Added
• Evidence added: Included PMID:32965908 reference to support the classification
• Issue tracking: Added proper metadata linking to this issue ("carotid body" should not be part of the cardiovascular system #3591)

Scientific Rationale:

The carotid body is functionally and developmentally a sensory organ of the peripheral nervous system. While anatomically located adjacent to the carotid artery bifurcation, it is not structurally part of the cardiovascular system. The previous classification was based on location rather than the organ's true biological function and developmental origin.

Next Steps:

• Pull Request: Fix carotid body classification: move from cardiovascular to peripheral nervous system #3594 is ready for review
• Branch:
• Validation: All ontology QA checks have passed

The fix ensures the carotid body is properly classified according to its role as a chemoreceptive sensory organ within the peripheral nervous system, as supported by the referenced literature.

@dragon-ai-agent