Currently, the term:
unfolded protein response variant (WBPhenotype:0001719)
has as a synonym:
"ER unfolded protein response abnormal"
and definition:
"Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones."
and has no children. There are several UPRs, not just ER, so we should remove the synonym
"ER unfolded protein response abnormal"
change the definition to:
"Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in cellular compartments, compared to control. One such response is the increase in expression of chaperones."
and create two new children terms:
"endoplasmic reticulum unfolded protein response variant"
with synonyms:
"ER unfolded protein response variant"
"ER UPR variant"
"endoplasmic reticulum UPR variant"
with definition:
"Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER), compared to control. One such response is the increase in expression of chaperones. "
AND
"mitochondrial unfolded protein response variant"
with synonyms:
"mitochondrial UPR variant"
"UPRmt variant"
with definition: "Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondria, compared to control. One such response is the increase in expression of chaperones."
Currently, the term:
unfolded protein response variant (WBPhenotype:0001719)
has as a synonym:
"ER unfolded protein response abnormal"
and definition:
"Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones."
and has no children. There are several UPRs, not just ER, so we should remove the synonym
"ER unfolded protein response abnormal"
change the definition to:
"Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in cellular compartments, compared to control. One such response is the increase in expression of chaperones."
and create two new children terms:
"endoplasmic reticulum unfolded protein response variant"
with synonyms:
"ER unfolded protein response variant"
"ER UPR variant"
"endoplasmic reticulum UPR variant"
with definition:
"Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER), compared to control. One such response is the increase in expression of chaperones. "
AND
"mitochondrial unfolded protein response variant"
with synonyms:
"mitochondrial UPR variant"
"UPRmt variant"
with definition: "Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondria, compared to control. One such response is the increase in expression of chaperones."