From 052086ec184379a605cb964dff085835dcd6957d Mon Sep 17 00:00:00 2001 From: violafanfani <35488779+violafanfani@users.noreply.github.com> Date: Thu, 8 Jan 2026 09:42:52 -0500 Subject: [PATCH 1/4] Add giraffe2 (#366) * Update conda-publish-manual.yml * fixing ignore * adding giraffe * adding flag for preprocessing only * moved load expression * added giraffe test * changing imports * changing macos * adding pytorch dependency * fixing macos and tables --- .github/workflows/conda-publish-manual.yml | 7 +- .github/workflows/conda-publish.yml | 2 +- .github/workflows/main.yml | 37 +- .github/workflows/test-conda-build.yml | 2 +- .gitignore | 8 +- conda/meta.yaml | 2 + netZooPy/__init__.py | 1 + netZooPy/giraffe/__init__.py | 4 + netZooPy/giraffe/giraffe.py | 319 +++++++ netZooPy/giraffe/utils.py | 35 + netZooPy/panda/__init__.py | 1 + netZooPy/panda/io.py | 76 ++ netZooPy/panda/panda.py | 230 ++---- requirements.txt | 1 + setup.py | 3 +- tests/giraffe/Toygiraffe_R_hat.txt | 914 +++++++++++++++++++++ tests/giraffe/Toygiraffe_TFA_hat.txt | 87 ++ tests/test_giraffe.py | 59 ++ 18 files changed, 1626 insertions(+), 162 deletions(-) create mode 100644 netZooPy/giraffe/__init__.py create mode 100644 netZooPy/giraffe/giraffe.py create mode 100644 netZooPy/giraffe/utils.py create mode 100644 netZooPy/panda/io.py create mode 100644 tests/giraffe/Toygiraffe_R_hat.txt create mode 100644 tests/giraffe/Toygiraffe_TFA_hat.txt create mode 100644 tests/test_giraffe.py diff --git a/.github/workflows/conda-publish-manual.yml b/.github/workflows/conda-publish-manual.yml index d11c0f27..93665e59 100644 --- a/.github/workflows/conda-publish-manual.yml +++ b/.github/workflows/conda-publish-manual.yml @@ -15,7 +15,7 @@ jobs: target-platform: linux-64 - os: ubuntu-24.04-arm target-platform: linux-aarch64 - - os: macos-13 + - os: macos-15 target-platform: osx-64 - os: macos-latest target-platform: osx-arm64 @@ -30,8 +30,7 @@ jobs: build-args: --target-platform ${{ matrix.target-platform }}${{ matrix.target-platform == 'linux-aarch64' && ' --no-test' || '' }} - name: Show built packages run: | - ls -lh rattler-build/**/*.conda || true + ls -lh output/**/*.conda || true - name: Upload package to Anaconda run: | - export ANACONDA_API_KEY=${{ secrets.ANACONDA_TOKEN }} - rattler-build upload anaconda -o netzoo rattler-build/**/*.conda \ No newline at end of file + rattler-build upload anaconda -o netzoo --api-key ${{ secrets.ANACONDA_TOKEN }} output/**/*.conda diff --git a/.github/workflows/conda-publish.yml b/.github/workflows/conda-publish.yml index 784085e5..18dfc8d4 100644 --- a/.github/workflows/conda-publish.yml +++ b/.github/workflows/conda-publish.yml @@ -14,7 +14,7 @@ jobs: target-platform: linux-64 - os: ubuntu-24.04-arm target-platform: linux-aarch64 - - os: macos-13 + - os: macos-15 target-platform: osx-64 - os: macos-latest target-platform: osx-arm64 diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml index a713ff24..2c09b4a5 100644 --- a/.github/workflows/main.yml +++ b/.github/workflows/main.yml @@ -1,39 +1,52 @@ name: netZooPy on: - push: + push: branches: - master - devel - pull_request: - branches: + pull_request: + branches: - master - devel -jobs: +jobs: build: runs-on: ${{ matrix.os }} strategy: - matrix: - os: [macos-13, ubuntu-latest] - python-version: [3.8, 3.9, '3.10'] + matrix: + os: [macos-15, ubuntu-latest] + python-version: [3.9, '3.10', '3.11', '3.12'] steps: - uses: actions/checkout@v3 - name: Set up Python ${{ matrix.python-version }} uses: actions/setup-python@v2 - with: - python-version: ${{ matrix.python-version }} + with: + python-version: ${{ matrix.python-version }} - name: Install dependencies and build package run: | python -m pip install --upgrade pip pip install flake8 pytest pytest-cov codecov echo ${{ matrix.os }} - if [[ "${{ matrix.os }}" == "macos-latest" ]];then echo "running this";brew install hdf5 c-blosc;export HDF5_DIR=/opt/homebrew/Cellar/hdf5/;export BLOSC_DIR=/opt/homebrew/Cellar/c-blosc/;fi + if [[ "${{ matrix.os }}" =~ ^macos- ]]; then + brew install hdf5 c-blosc lzo + export HDF5_DIR=$(brew --prefix hdf5) + export BLOSC_DIR=$(brew --prefix c-blosc) + export LZO_DIR=$(brew --prefix lzo) + # Set library and include paths for macOS + export LDFLAGS="-L$(brew --prefix hdf5)/lib -L$(brew --prefix c-blosc)/lib -L$(brew --prefix lzo)/lib" + export CPPFLAGS="-I$(brew --prefix hdf5)/include -I$(brew --prefix c-blosc)/include -I$(brew --prefix lzo)/include" + export PKG_CONFIG_PATH="$(brew --prefix hdf5)/lib/pkgconfig:$(brew --prefix c-blosc)/lib/pkgconfig" + fi + if [[ "${{ matrix.os }}" =~ ^ubuntu- ]]; then + sudo apt-get update + sudo apt-get install -y liblzo2-dev libhdf5-dev libblosc-dev + fi if [ -f requirements.txt ]; then pip install -r requirements.txt; fi pip install -e . - name: Lint with flake8 - run: | + run: | # stop the build if there are Python syntax errors or undefined names flake8 . --count --select=E9,F63,F7,F82 --show-source --statistics # exit-zero treats all errors as warnings. The GitHub editor is 127 chars wide @@ -43,4 +56,4 @@ jobs: pytest --cov=netZooPy tests - name: Report coverage run: | - codecov + codecov \ No newline at end of file diff --git a/.github/workflows/test-conda-build.yml b/.github/workflows/test-conda-build.yml index e2516fb4..a6cc7354 100644 --- a/.github/workflows/test-conda-build.yml +++ b/.github/workflows/test-conda-build.yml @@ -16,7 +16,7 @@ jobs: target-platform: linux-64 - os: ubuntu-24.04-arm target-platform: linux-aarch64 - - os: macos-13 + - os: macos-15 target-platform: osx-64 - os: macos-latest target-platform: osx-arm64 diff --git a/.gitignore b/.gitignore index d837f149..60875306 100644 --- a/.gitignore +++ b/.gitignore @@ -53,9 +53,13 @@ panda_remove.txt pan_test_panda.txt tests/lioness/dragon/lioness_dragon_results/ docs/_build/ -netZooPy/panda/io.py +#netZooPy/panda/io.py debug_bonobo.py !recipe/ !recipe/recipe.yaml -!recipe/test.py \ No newline at end of file +!recipe/test.py + +pixi/* +.pixi/* +pixi* diff --git a/conda/meta.yaml b/conda/meta.yaml index 26e5980e..5999dfd3 100644 --- a/conda/meta.yaml +++ b/conda/meta.yaml @@ -23,6 +23,7 @@ requirements: - click - pandas - pytables + - pytorch run: - numpy>=1.19.2 - python {{ python }} @@ -36,6 +37,7 @@ requirements: - click - pandas - pytables + - pytorch test: commands: diff --git a/netZooPy/__init__.py b/netZooPy/__init__.py index 6a2c58aa..c4dc76f1 100644 --- a/netZooPy/__init__.py +++ b/netZooPy/__init__.py @@ -7,5 +7,6 @@ from netZooPy import condor from netZooPy import sambar from netZooPy import bonobo +from netZooPy import giraffe __version__ = "0.10.9" diff --git a/netZooPy/giraffe/__init__.py b/netZooPy/giraffe/__init__.py new file mode 100644 index 00000000..6193abc5 --- /dev/null +++ b/netZooPy/giraffe/__init__.py @@ -0,0 +1,4 @@ +from __future__ import absolute_import + +from .giraffe import Giraffe +from .utils import * diff --git a/netZooPy/giraffe/giraffe.py b/netZooPy/giraffe/giraffe.py new file mode 100644 index 00000000..690f9043 --- /dev/null +++ b/netZooPy/giraffe/giraffe.py @@ -0,0 +1,319 @@ +import random +#from sklearn.linear_model import LinearRegression +import torch +from torch import nn +from torch.functional import F +from typing import Callable +from netZooPy.cobra import * +from netZooPy.giraffe.utils import * +import logging +import pandas as pd + +from torch.optim import Adam +from torch.optim.optimizer import required + + +class Giraffe(object): + """ + GIRAFFE infers regulation and transcription factor activity using + + gene expression + TF DNA binding motif + TF interactions (PPI) + + while (optionally) controlling for covariates of interest (e.g. age). + There are G genes, TF transcription factors, and n samples (cells, patients, ...) + + Parameters + ----------- + expression : numpy array or pandas dataframe + Dimension G x n + prior : numpy array or pandas dataframe + TF-gene regulatory network based on TF motifs as a + matrix of size (tf,g), g=number of genes, tf=number of TFs + ppi : numpy array or pandas dataframe + TF-TF protein interaction network as a matrix of size (tf, tf) + Must be symmetrical and have ones on the diagonal + design_matrix : np.ndarray, pd.DataFrame + COBRA design matrix of size (n, q), n = number of samples, q = number of covariates + cobra_covariate_to_keep : int + Zero-indedex base of COBRA co-expression component to use + iterations : int + number of iterations of the algorithm + lr : float + the learning rate + lam: + + Public Functions + --------- + get_regulation : numpy array + Returns the predicted TF-gene complete regulatory network as an adjacency matrix of size (tf,g) + get_tfa : numpy array + Returns the predicted transcription factor activity as an adjacency matrix of size (tf,n) + + References + ------------- + Author: Soel Micheletti + """ + + def __init__( + self, + expression, + prior, + ppi, + adjusting=None, + design_matrix=None, + cobra_covariate_to_keep=0, + l1=0, + max_iter=2000, + min_iter=200, + lr=1e-5, + lam=None, + balance_fn = None, + save_computation = False, + seed=42, # For reproducibility + ) -> None: + + torch.manual_seed(seed) + random.seed(seed) + np.random.seed(seed) + self._save_computation = save_computation + self.process_data( + expression, + prior, + ppi, + adjusting, + design_matrix, + cobra_covariate_to_keep + ) + self._max_iter = max_iter + self._min_iter = min_iter + self._lr = lr + self._l = l1 + self._lam = lam + self._balance_fn = balance_fn + if self._lam is not None and self._balance_fn is not None: + raise ValueError("Can't set both custom weights and custom weight learning function! Please provide only one of both options. ") + self._R, self._TFA = self._compute_giraffe() + + def process_data( + self, + expression, + motif, + ppi, + adjusting, + design_matrix, + cobra_covariate_to_keep + ): + """ + Processes data files into normzalized data matrices. + + :param expression: numpy matrix or pandas dataframe containing gene expression data. + :param motif: numpy matrix or pandas dataframe containing motif data. + :param ppi: numpy or pandas dataframe containing PPI data. Must be symmetrical. + :param adjusting: vector of covariates that needs to be adjusted. + """ + self._expression = expression + self._motif = motif + self._ppi = ppi + + if isinstance(expression, pd.DataFrame): + self._expression = expression.to_numpy() + if isinstance(motif, pd.DataFrame): + self._motif = motif.to_numpy() + if isinstance(ppi, pd.DataFrame): + self._ppi = ppi.to_numpy() + + check_symmetric(self._ppi) # Check that ppi has legal structure. + + if not isinstance(self._expression, np.ndarray): + raise ValueError( + "Error in processing expression data. Please provide a numpy array or a pandas dataframe. " + ) + if not isinstance(self._motif, np.ndarray): + raise ValueError( + "Error in processing motif data. Please provide a numpy array or a pandas dataframe. " + ) + if not isinstance(self._ppi, np.ndarray): + raise ValueError( + "Error in processing PPI data. Please provide a numpy array or a pandas dataframe. " + ) + + if adjusting is None: + self._adjusting = None + else: + if len(adjusting.shape) == 1: + adjusting = adjusting.reshape(len(adjusting), 1) + self._adjusting = torch.Tensor(np.zeros(adjusting.shape)) + if isinstance(adjusting, pd.DataFrame): + adjusting = adjusting.to_numpy() + if adjusting is not None and not isinstance(adjusting, np.ndarray): + raise ValueError( + "Error in processing adjusting covariates. Please provide a numpy array or a pandas dataframe. " + ) + if adjusting is not None: + for i in range(adjusting.shape[1]): + tmp = torch.Tensor(adjusting[:, i]) + tmp /= torch.norm(tmp) + self._adjusting[:, i] = tmp + + # Normalize motif and PPI + self._motif = motif / np.sqrt(np.trace(motif.T @ motif)) + self._ppi = self._ppi / np.trace(self._ppi) + + self._C = 0 + if not self._save_computation: + # Compute co-expression matrix + if (np.cov(self._expression).diagonal() == 0).any(): + self._expression += 1e-8 + + if design_matrix is not None: + psi, Q, d, g = cobra(design_matrix, self._expression) + if cobra_covariate_to_keep < 0 or cobra_covariate_to_keep >= psi.shape[0]: + raise AttributeError( + "Invalid COBRA component! Valid COBRA components are in range " + str(0) + " - " + str(psi.shape[0] - 1) + ) + self._C = Q.dot(np.diag(psi[cobra_covariate_to_keep,])).dot(Q.T) + else: + self._C = np.corrcoef(self._expression) + self._C /= np.trace(self._C) + + if design_matrix is not None: + self._expression = limma(exprs=self._expression, pheno=pd.DataFrame(design_matrix), covariate_formula = "~ -1") + + def _compute_giraffe(self): + """ + Giraffe optimization. + :return: R : matrix g x tf, partial effects between tanscription factor and gene. + TFA : matrix tf x n, transcrption factor activity. + """ + + variables_to_adjust = 0 + if self._adjusting is not None: + variables_to_adjust = self._adjusting.shape[1] + + giraffe_model = Model(np.random.random((self._motif.shape[1], self._expression.shape[1])), self._motif, variables_to_adjust) + optim = torch.optim.Adam(giraffe_model.parameters(), lr=self._lr) # We run Adam to optimize f(R, TFA) + if self._l > 0: + optim = ProxAdam(giraffe_model.parameters(), lr=self._lr, lambda_ = self._l) + + last_loss = float('inf') + converged = False + for i in range(self._max_iter): + pred = giraffe_model( + torch.Tensor(self._expression), + torch.Tensor(self._ppi), + torch.Tensor(self._C), + self._lam, + self._balance_fn, + self._adjusting, + self._save_computation + ) # Compute f(R, TFA) + loss = F.mse_loss(pred, torch.norm( + torch.Tensor(np.zeros((3, 3))))).sqrt() # Minimization problem: loss = ||f(R, TFA)|| + optim.zero_grad() # Reset gradients + loss.backward() + optim.step() # Adam step + if i >= self._min_iter and abs(last_loss - loss.detach().numpy()) / last_loss < 1e-3: + converged=True + break + last_loss = loss.detach().numpy() + + if not converged: + logging.warn('GIRAFFE did not converge and was stopped after ' + str(self._max_iter) + ' iterations. Try increasing the max_iter parameter.') + R = giraffe_model.R.detach().numpy() + TFA = torch.abs(giraffe_model.TFA.detach()).numpy() + return R, TFA + + def get_regulation(self): + return self._R + + def get_tfa(self): + return self._TFA + # TFA_giraffe = np.zeros(self._TFA.shape) + # for i in range(self._TFA.shape[1]): + # TFA_giraffe[:, i] = LinearRegression(fit_intercept=False, positive=True).fit(self._R, self._expression[:, i]).coef_ + # return TFA_giraffe + + +class Model(nn.Module): + def __init__( + self, + tfa_prior, + motif, + variables_to_adjust + ): + super().__init__() + self.TFA = nn.Parameter(torch.Tensor(tfa_prior)) + self.R = nn.Parameter(torch.Tensor(motif)) + self.variables_to_adjust = variables_to_adjust + self.coefs = nn.Parameter(torch.Tensor(torch.ones((motif.shape[0], self.variables_to_adjust)))) + + def forward( + self, + Y, + PPI, + C, + lam, + balance_fn, + adjusting, + save_computation + ): + if adjusting is None: + L1 = torch.norm(Y - torch.matmul(self.R, torch.abs(self.TFA))) ** 2 + L2 = torch.norm(torch.matmul(torch.t(self.R), self.R) - PPI) ** 2 + L3 = torch.norm(torch.Tensor(torch.zeros((2, 2)))) + if not save_computation: + L3 = torch.norm(torch.matmul(self.R, torch.t(self.R)) - C) ** 2 + L4 = torch.norm(torch.matmul(torch.abs(self.TFA), torch.t(torch.abs(self.TFA))) - PPI) ** 2 + L5 = torch.norm(self.R) ** 2 + weights = self._get_weights(lam, balance_fn, L1, L2, L3, L4, L5) + return weights[0] * L1 + weights[1] * L2 + weights[2] * L3 + weights[3] * L4 + weights[4] * L5 + else : + L1 = torch.norm(Y - torch.matmul(torch.hstack([self.R, self.coefs]), torch.vstack([torch.abs(self.TFA), torch.t(adjusting)]))) ** 2 + L2 = torch.norm(torch.matmul(torch.t(self.R), self.R) - PPI) ** 2 + L3 = torch.norm(torch.Tensor(torch.zeros((2, 2)))) + if not save_computation: + L3 = torch.norm(torch.matmul(self.R, torch.t(self.R)) - C) ** 2 + L4 = torch.norm(torch.matmul(torch.vstack([torch.abs(self.TFA), torch.t(adjusting)]), torch.t(torch.vstack([torch.abs(self.TFA), torch.t(adjusting)]))) - torch.hstack([torch.vstack([PPI, torch.Tensor(np.ones((self.variables_to_adjust, self.R.shape[1])))]), torch.Tensor(torch.ones((self.R.shape[1] + self.variables_to_adjust, self.variables_to_adjust)))])) ** 2 + L5 = torch.norm(torch.hstack([self.R, self.coefs])) ** 2 + weights = self._get_weights(lam, balance_fn, L1, L2, L3, 0, torch.Tensor([0])) + return weights[0] * L1 + 3 * weights[1] * L2 + weights[2] * L3 + weights[3] * L4 + weights[4] * L5 + + def _get_weights(self, lam, balance_fn, L1, L2, L3, L4, L5): + weights = [1, 1, 1, 1, 1] + if lam is not None: + weights = lam + elif balance_fn is not None: + weights = balance_fn(L1, L2, L3, L5) + else: + sum = L1.item() + L2.item() + L3.item() + L5.item() + weights = [1 - L1.item() / sum, 1 - L2.item() / sum, 1 - L3.item() / sum, 1, 1] + return weights + +class ProxAdam(Adam ): + def __init__(self, params, lr=required, lambda_=0): + + kwargs = dict(lr=lr) + super().__init__(params, **kwargs) + self._lambda = lambda_ + proxs = [self.soft_thresholding] + if len(proxs) != len(self.param_groups): + raise ValueError("Invalid length of argument proxs: {} instead of {}".format(len(proxs), len(self.param_groups))) + + for group, prox in zip(self.param_groups, list(proxs)): + group.setdefault('prox', prox) + + def step(self): + # perform a gradient step + super().step() + + for group in self.param_groups: + prox = group['prox'] + + # apply the proximal operator to each parameter in a group + for p in group['params']: + p.data = prox(p.data) + + def soft_thresholding(self, x): + return torch.sign(x) * torch.nn.functional.relu(torch.abs(x) - self._lambda) diff --git a/netZooPy/giraffe/utils.py b/netZooPy/giraffe/utils.py new file mode 100644 index 00000000..d648cf29 --- /dev/null +++ b/netZooPy/giraffe/utils.py @@ -0,0 +1,35 @@ +import numpy as np +import patsy + + +def check_symmetric(ppi): + """ + Raises an exception if ppi does not have the expected structure. + + :param ppi: matrix to be checked + """ + if ppi.shape[0] != ppi.shape[1]: + raise Exception( + "PPI must be a squared matrix. " + ) + if np.diag(ppi).any() != 1: + raise Exception( + "PPI matrix must have ones on the diagonal. " + ) + if np.any(np.abs(ppi - ppi.T) > 1e-8): + raise Exception( + "PPI matrix must be symmetrical. " + ) + +def limma(pheno, exprs, covariate_formula, design_formula='1', rcond=1e-8): + design_matrix = patsy.dmatrix(design_formula, pheno) + + design_matrix = design_matrix[:,1:] + rowsum = design_matrix.sum(axis=1) -1 + design_matrix=(design_matrix.T+rowsum).T + + covariate_matrix = patsy.dmatrix(covariate_formula, pheno) + design_batch = np.hstack((covariate_matrix,design_matrix)) + coefficients, res, rank, s = np.linalg.lstsq(design_batch, exprs.T, rcond=rcond) + beta = coefficients[-design_matrix.shape[1]:] + return exprs - design_matrix.dot(beta).T diff --git a/netZooPy/panda/__init__.py b/netZooPy/panda/__init__.py index 3cd5f09f..4c994d56 100755 --- a/netZooPy/panda/__init__.py +++ b/netZooPy/panda/__init__.py @@ -3,3 +3,4 @@ from .panda import Panda from .analyze_panda import AnalyzePanda from .calculations import compute_panda +from .io import load_motif, load_expression diff --git a/netZooPy/panda/io.py b/netZooPy/panda/io.py new file mode 100644 index 00000000..bff67c8a --- /dev/null +++ b/netZooPy/panda/io.py @@ -0,0 +1,76 @@ +from __future__ import print_function + +import math +import numpy as np +import sys +import pandas as pd + + +def load_motif(motif_file): + if type(motif_file) is str: + # If motif_file is a filename + motif_data = pd.read_csv(motif_file, sep="\t", header=None) + motif_tfs = sorted(set(motif_data[0])) + motif_genes = sorted(set(motif_data[1])) + elif type(motif_file) is not str: + # If motif_file is an object + if motif_file is None: + # Computation without motif + motif_data = None + motif_genes = [] + motif_tfs = [] + else: + # If motif_file is an object, it needs to be a dataframe + if not isinstance(motif_file, pd.DataFrame): + raise Exception( + "Please provide a pandas dataframe for motif data with column names as 'source', 'target', and 'weight'." + ) + if ("source" not in motif_file.columns) or ( + "target" not in motif_file.columns + ): + print('renaming motif columns to "source", "target" and "weight" ') + motif_file.columns = ["source", "target", "weight"] + motif_data = pd.DataFrame(motif_file.values) + motif_tfs = sorted(set(motif_file["source"])) + motif_genes = sorted(set(motif_file["target"])) + return(motif_data, motif_tfs, motif_genes) + + +def load_expression(expression_file, with_header = False, start = 1, end = None): + if type(expression_file) is str: + # If we pass an expression file, check if we have a 'with header' flag and read it + + if with_header: + # Read data with header + expression_data = pd.read_csv( + expression_file, sep="\t", index_col=0 + ) + else: + expression_data = pd.read_csv( + expression_file, sep="\t", header=None, index_col=0 + ) + # assign expression data and samples/gene names + expression_data = expression_data.iloc[:, (start-1):end] + expression_genes = expression_data.index.tolist() + expression_samples = expression_data.columns.astype(str) + + elif type(expression_file) is not str: + # Pass expression as a dataframe + if expression_file is not None: + if not isinstance(expression_file, pd.DataFrame): + raise Exception( + "Please provide a pandas dataframe for expression data." + ) + expression_data = expression_file.iloc[:, (start-1):end] # pd.read_csv(expression_file, sep='\t', header=None, index_col=0) + expression_genes = expression_data.index.tolist() + expression_samples = expression_data.columns.astype(str) + else: + expression_data = None + expression_genes = None + expression_samples = None + print('No valid expression file is passed') + + return(expression_data, expression_genes, expression_samples) + + +#def load_ppi(ppi_file): diff --git a/netZooPy/panda/panda.py b/netZooPy/panda/panda.py index ed959ea7..34adfd42 100755 --- a/netZooPy/panda/panda.py +++ b/netZooPy/panda/panda.py @@ -6,6 +6,7 @@ import numpy as np from netZooPy.cobra import cobra from netZooPy.panda import calculations as calc +from netZooPy.panda import io as io import os class Panda(object): @@ -124,12 +125,12 @@ def __init__( with_header=False, cobra_design_matrix = None, cobra_covariate_to_keep = 0, - tmp_folder = './tmp/' + tmp_folder = './tmp/', + process_data_only = False ): """ Intialize instance of Panda class and load data. """ # Read data - self.processData( modeProcess, motif_file, @@ -143,75 +144,77 @@ def __init__( cobra_design_matrix=cobra_design_matrix, cobra_covariate_to_keep=cobra_covariate_to_keep ) + print(modeProcess,motif_file,expression_file,ppi_file,save_memory,remove_missing,keep_expression_matrix) if hasattr(self, "export_panda_results"): return - - # ===================================================================== - # Network normalization - # ===================================================================== - - self.precision = precision - with Timer("Normalizing networks ..."): - self.correlation_matrix = self._normalize_network(self.correlation_matrix) - with np.errstate(invalid="ignore"): # silly warning bothering people - self.motif_matrix = self._normalize_network( - self.motif_matrix_unnormalized + if (process_data_only==False): + # ===================================================================== + # Network normalization + # ===================================================================== + + self.precision = precision + + with Timer("Normalizing networks ..."): + self.correlation_matrix = self._normalize_network(self.correlation_matrix) + with np.errstate(invalid="ignore"): # silly warning bothering people + self.motif_matrix = self._normalize_network( + self.motif_matrix_unnormalized + ) + self.ppi_matrix = self._normalize_network(self.ppi_matrix) + if self.precision == "single": + self.correlation_matrix = np.float32(self.correlation_matrix) + self.motif_matrix = np.float32(self.motif_matrix) + self.ppi_matrix = np.float32(self.ppi_matrix) + # ===================================================================== + # Clean up useless variables to release memory + # ===================================================================== + self.tfs, self.genes = self.unique_tfs, self.gene_names + + if (save_memory==True): + print("Clearing motif and ppi data, unique tfs, and gene names for speed") + del self.unique_tfs, self.gene_names, self.motif_matrix_unnormalized + print("WARNING: save_memory will be uncoupled from the output behavior.\n Pass as_adjacency to save the output panda as adjacency matrix") + # ===================================================================== + # Saving middle data to tmp + # ===================================================================== + self.tmp_folder = tmp_folder + if save_tmp: + with Timer("Saving expression matrix and normalized networks in %s..." %str(self.tmp_folder)): + os.makedirs(self.tmp_folder,exist_ok=True) + if self.expression_data is not None: + np.save(self.tmp_folder + "expression.npy", self.expression_data.values) + np.save(self.tmp_folder + "motif.normalized.npy", self.motif_matrix) + np.save(self.tmp_folder + "ppi.normalized.npy", self.ppi_matrix) + + + # delete expression data + del self.expression_data + + # ===================================================================== + # Running PANDA algorithm + # ===================================================================== + if self.motif_data is not None: + print("Running PANDA algorithm ...") + self.panda_network = self.panda_loop( + self.correlation_matrix, + self.motif_matrix, + self.ppi_matrix, + computing, + alpha, + ) + # label dataframe + self.panda_network = pd.DataFrame( + self.panda_network, index=self.tfs, columns=self.genes + ) + else: + self.panda_network = self.correlation_matrix + self.__pearson_results_data_frame() + # label dataframe + self.panda_network = pd.DataFrame( + self.panda_network, index=self.genes, columns=self.genes ) - self.ppi_matrix = self._normalize_network(self.ppi_matrix) - if self.precision == "single": - self.correlation_matrix = np.float32(self.correlation_matrix) - self.motif_matrix = np.float32(self.motif_matrix) - self.ppi_matrix = np.float32(self.ppi_matrix) - # ===================================================================== - # Clean up useless variables to release memory - # ===================================================================== - self.tfs, self.genes = self.unique_tfs, self.gene_names - - if (save_memory==True): - print("Clearing motif and ppi data, unique tfs, and gene names for speed") - del self.unique_tfs, self.gene_names, self.motif_matrix_unnormalized - print("WARNING: save_memory will be uncoupled from the output behavior.\n Pass as_adjacency to save the output panda as adjacency matrix") - # ===================================================================== - # Saving middle data to tmp - # ===================================================================== - self.tmp_folder = tmp_folder - if save_tmp: - with Timer("Saving expression matrix and normalized networks in %s..." %str(self.tmp_folder)): - os.makedirs(self.tmp_folder,exist_ok=True) - if self.expression_data is not None: - np.save(self.tmp_folder + "expression.npy", self.expression_data.values) - np.save(self.tmp_folder + "motif.normalized.npy", self.motif_matrix) - np.save(self.tmp_folder + "ppi.normalized.npy", self.ppi_matrix) - - - # delete expression data - del self.expression_data - - # ===================================================================== - # Running PANDA algorithm - # ===================================================================== - if self.motif_data is not None: - print("Running PANDA algorithm ...") - self.panda_network = self.panda_loop( - self.correlation_matrix, - self.motif_matrix, - self.ppi_matrix, - computing, - alpha, - ) - # label dataframe - self.panda_network = pd.DataFrame( - self.panda_network, index=self.tfs, columns=self.genes - ) - else: - self.panda_network = self.correlation_matrix - self.__pearson_results_data_frame() - # label dataframe - self.panda_network = pd.DataFrame( - self.panda_network, index=self.genes, columns=self.genes - ) def __remove_missing(self): """ Removes the genes and TFs that are not present in one of the priors. Works only if modeProcess='legacy'. @@ -326,82 +329,26 @@ def processData( # Data loading # ===================================================================== ### Loading Motif - if type(motif_file) is str: - # If motif_file is a filename - with Timer("Loading motif data ..."): - self.motif_data = pd.read_csv(motif_file, sep="\t", header=None) - self.motif_tfs = sorted(set(self.motif_data[0])) - self.motif_genes = sorted(set(self.motif_data[1])) - # self.num_tfs = len(self.unique_tfs) - # print('Unique TFs:', self.num_tfs) - elif type(motif_file) is not str: - # If motif_file is an object - if motif_file is None: - # Computation without motif - self.motif_data = None - self.motif_genes = [] - self.motif_tfs = [] - else: - # If motif_file is an object, it needs to be a dataframe - if not isinstance(motif_file, pd.DataFrame): - raise Exception( - "Please provide a pandas dataframe for motif data with column names as 'source', 'target', and 'weight'." - ) - if ("source" not in motif_file.columns) or ( - "target" not in motif_file.columns - ): - print('renaming motif columns to "source", "target" and "weight" ') - motif_file.columns = ["source", "target", "weight"] - self.motif_data = pd.DataFrame(motif_file.values) - self.motif_tfs = sorted(set(motif_file["source"])) - self.motif_genes = sorted(set(motif_file["target"])) - # self.num_tfs = len(self.unique_tfs) - # print('Unique TFs:', self.num_tfs) - + with Timer("Loading motif data ..."): + self.motif_data, self.motif_tfs, self.motif_genes = io.load_motif(motif_file) + ### Loading expression - if type(expression_file) is str: - # If we pass an expression file, check if we have a 'with header' flag and read it - with Timer("Loading expression data ..."): - if with_header: - # Read data with header - self.expression_data = pd.read_csv( - expression_file, sep="\t", index_col=0 - ) - else: - self.expression_data = pd.read_csv( - expression_file, sep="\t", header=None, index_col=0 - ) - # assign expression data and samples/gene names - self.expression_data = self.expression_data.iloc[:, (start-1):end] - self.expression_genes = self.expression_data.index.tolist() - self.expression_samples = self.expression_data.columns.astype(str) - # self.num_genes = len(self.gene_names) - # print('Expression matrix:', self.expression_data.shape) - elif type(expression_file) is not str: - # Pass expression as a dataframe - if expression_file is not None: - if not isinstance(expression_file, pd.DataFrame): - raise Exception( - "Please provide a pandas dataframe for expression data." - ) - self.expression_data = expression_file.iloc[:, (start-1):end] # pd.read_csv(expression_file, sep='\t', header=None, index_col=0) - self.expression_genes = self.expression_data.index.tolist() - self.expression_samples = self.expression_data.columns.astype(str) - # self.num_genes = len(self.gene_names) - # print('Expression matrix:', self.expression_data.shape) - else: - # If no expression is passed - self.gene_names = self.motif_genes - self.expression_genes = self.motif_genes - self.num_genes = len(self.gene_names) - self.expression_data = ( - None # pd.DataFrame(np.identity(self.num_genes, dtype=int)) - ) - print( - # TODO: Marouen check here. Here we do not pass the identity matrix - "No Expression data given: correlation matrix will be an identity matrix of size", - len(self.motif_genes), - ) + with Timer("Loading expression data ..."): + self.expression_data, self.expression_genes, self.expression_samples = io.load_expression(expression_file, with_header = with_header, start = start, end = end) + + if ((self.expression_data is None) & (self.expression_genes is None) & (self.expression_samples is None)): + # If no expression is passed + self.gene_names = self.motif_genes + self.expression_genes = self.motif_genes + self.num_genes = len(self.gene_names) + self.expression_data = ( + None # pd.DataFrame(np.identity(self.num_genes, dtype=int)) + ) + print( + # TODO: Marouen check here. Here we do not pass the identity matrix + "No Expression data given: correlation matrix will be an identity matrix of size", + len(self.motif_genes), + ) if len(self.expression_genes) != len(np.unique(self.expression_genes)): print( @@ -409,6 +356,7 @@ def processData( ) ### Loading the PPI + # #TODO: move this to io if type(ppi_file) is str: with Timer("Loading PPI data ..."): self.ppi_data = pd.read_csv(ppi_file, sep="\t", header=None) diff --git a/requirements.txt b/requirements.txt index 1f8151d5..7e2c6abf 100755 --- a/requirements.txt +++ b/requirements.txt @@ -7,3 +7,4 @@ igraph joblib statsmodels click +torch \ No newline at end of file diff --git a/setup.py b/setup.py index c9f5c08f..df1c6b69 100755 --- a/setup.py +++ b/setup.py @@ -22,7 +22,8 @@ 'joblib>=1.1.0', 'statsmodels>=0.12.2', 'click', - 'tables' + 'tables', + 'torch' ], zip_safe=False, # add cli interface diff --git a/tests/giraffe/Toygiraffe_R_hat.txt b/tests/giraffe/Toygiraffe_R_hat.txt new file mode 100644 index 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0.26999375 0.004374154 0.9763498 0.9637421 0.39315042 0.72636586 0.34380123 0.6690882 0.8034251 0.9447511 0.39820743 0.7812928 0.26392356 0.98832715 0.02376448 0.6015238 0.65750086 0.68604046 0.11838261 0.93652475 0.17917809 0.6207484 0.22067113 0.30521157 0.54445344 0.41518852 0.15822063 0.16893126 0.41613996 0.75527793 0.8959595 0.08212263 0.39109898 0.09824067 0.014587473 0.6597136 0.6004445 0.16101395 0.23180786 +TCF3 0.021702964 0.8329421 0.9726855 0.13345441 0.22947021 0.8664044 0.9244586 0.4176226 0.048617687 0.03738695 0.57194495 0.39089024 0.026647603 0.5812474 0.009297571 0.78536683 0.3044281 0.038253162 0.5863473 0.39567968 0.9717953 0.54219365 0.27323428 0.7074338 0.26948705 0.90223813 0.37271723 0.5478635 0.048568208 0.4241164 0.83035856 0.80364364 0.22231373 0.22407423 0.8153003 0.9283933 0.093355976 0.44805387 0.3354494 0.8686834 0.08152012 0.20912081 0.75046325 0.049288895 0.49053064 0.44010213 0.33239642 0.3925676 0.5279355 0.15936247 +TEAD1 0.56999075 0.8034271 0.7581557 0.15189464 0.14724427 0.26616943 0.35906968 0.40645066 0.6776922 0.05467531 0.032667812 0.3899056 0.6951586 0.19143021 0.6394993 0.25782317 0.88408107 0.8936848 0.29528233 0.22798869 0.40929896 0.2385264 0.6703786 0.8240595 0.67108685 0.8223452 0.39498731 0.15431173 0.73594576 0.35846955 0.66926575 0.2686389 0.07922463 0.9905766 0.15419634 0.9864158 0.9752748 0.791813 0.6574177 0.57580197 0.86409646 0.28743452 0.4656762 0.6173848 0.4091856 0.42548144 0.32827973 0.56222683 0.8485693 0.19952324 +TFAP2A 0.93242794 0.68708247 0.8212681 0.55418545 0.77751154 0.0141953295 0.8163752 0.038133904 0.88790834 0.9899576 0.29206273 0.20831339 0.76335824 0.25102147 0.8635572 0.10083753 0.12395021 0.97714645 0.6718339 0.8448822 0.32232442 0.67447865 0.5922366 0.60114497 0.6805272 0.57335395 0.4270575 0.2739177 0.7665762 0.22426726 0.6903492 0.23132756 0.62332505 0.74507314 0.21670876 0.05793818 0.12896858 0.6039919 0.8474412 0.042991847 0.73214614 0.33931363 0.4765234 0.9268544 0.3299666 0.463332 0.011677443 0.079593904 0.25658658 0.025847187 +TLX1 0.6293702 0.42439336 0.54613996 0.17264195 0.29392707 0.66181934 0.9632974 0.048411768 0.8883792 0.57487607 0.56191456 0.49827325 0.06738907 0.08787184 0.5989069 0.3389536 0.915263 0.40458563 0.14127643 0.7127138 0.29134843 0.5234652 0.69582754 0.89825886 0.7901859 0.6743558 0.67762816 0.9439194 0.29381913 2.9429202e-07 0.26994967 0.2158861 0.6598295 0.6317065 0.5914563 0.014238298 0.7267729 0.32152548 0.6630508 0.55457336 0.34072605 0.13257103 0.09241374 0.8295132 0.91639245 0.64778286 0.1014291 0.40002245 0.72693396 0.77781576 +TP53 0.116213694 2.0925854e-06 0.7101319 0.35459116 0.2524764 0.010892434 0.5382942 0.8491457 0.95562655 0.56373984 0.51245636 0.08305137 0.5468677 0.3779742 0.60513014 0.3867214 0.2382942 0.092960306 0.31291366 0.0946399 0.17489177 0.98533106 0.4420986 0.52986664 0.8716133 0.9935636 0.58070946 0.8104687 0.3249361 0.30373904 0.40069887 0.67050207 0.6801866 0.31323457 0.13120484 0.6303911 0.12632072 0.5764875 0.691417 0.6986064 0.75146705 0.87085426 0.497954 0.728244 0.6171677 0.18463477 0.023684675 0.28253663 0.44102868 0.61510086 +USF1 0.8479542 0.1942405 0.12354462 0.9614747 0.10603947 0.47648612 0.5835585 0.5393694 0.08402725 0.05502183 0.1034786 0.5835826 0.5423398 0.23173574 0.635769 0.81806237 0.03957411 0.496125 0.6873054 0.25030705 0.30576593 0.6116328 0.89593005 0.80791926 0.581125 0.72821647 0.36281767 0.63896036 0.46417663 0.18793099 0.69973326 0.5544594 0.3566167 0.90933406 0.0189291 0.31376818 0.054876357 0.7645222 0.7001022 0.3293473 0.6736578 0.39393225 0.7542486 0.45217872 0.41027483 0.9327248 0.24887429 0.118442506 0.5825379 0.9673167 +VDR 0.3758344 0.060031723 0.33730036 0.5039265 0.15991792 0.6560971 0.99574417 0.44973466 0.35272378 0.39869925 0.11314139 0.8812685 0.41282085 0.38526958 0.65768516 0.44002852 0.6462285 0.05944138 0.81171834 0.9384989 0.6467603 0.95256084 0.14942715 0.47541127 0.5998016 0.5797314 0.399457 0.33607945 0.12481905 0.38973755 0.16065586 0.73236054 0.20682602 0.05656045 0.5503611 0.59322464 0.869908 0.57497656 0.34347594 0.80100685 0.5382739 0.07727523 0.56384546 0.9060134 0.39430782 0.2943209 0.14146447 0.14944072 0.4307665 0.5936748 +YY1 0.0786103 0.93756324 0.75312835 0.5846186 0.8264334 0.07818151 0.4748337 0.62808794 0.82664776 0.7814643 0.27506435 0.9388749 0.122340694 0.8731284 0.96893495 0.17514823 0.72006094 0.03828039 0.4034179 0.5142781 0.5786399 0.93393195 0.67024535 0.47927287 0.80766964 0.9485274 0.02006107 0.98051596 0.0841269 0.81238157 0.27832976 0.13017426 0.43785065 0.64195144 0.37894684 0.05256014 0.5974559 0.9003981 0.3812103 0.21432754 0.44057232 0.046357423 0.8184823 0.8243355 0.5859953 0.35109785 0.7977781 0.5526819 0.823927 0.6294536 diff --git a/tests/test_giraffe.py b/tests/test_giraffe.py new file mode 100644 index 00000000..256408c5 --- /dev/null +++ b/tests/test_giraffe.py @@ -0,0 +1,59 @@ +import pytest +import os +from netZooPy.panda.panda import Panda +from netZooPy.giraffe import giraffe +import pandas as pd +import numpy as np +import subprocess +import netZooPy.command_line as cmd + +# Use the logger +import logging +LOGGER = logging.getLogger(__name__) + +def test_giraffe(): + """First giraffe test with ToyData + """ + LOGGER.warning('Test1') + + ppi_file = "tests/puma/ToyData/ToyPPIData.txt" + motif_file = "tests/puma/ToyData/ToyMotifData.txt" + expression_file = "tests/puma/ToyData/ToyExpressionData.txt" + + tfa_file = "tests/giraffe/Toygiraffe_TFA_hat.txt" + r_file = "tests/giraffe/Toygiraffe_R_hat.txt" + + + panda_obj = Panda( + expression_file, + motif_file, + ppi_file, + modeProcess="intersection", + with_header=False, + process_data_only = True) + + # get the preprocessed data from panda object + expression = panda_obj.expression + motif = panda_obj.motif_matrix_unnormalized + ppi = panda_obj.ppi_matrix + + # Run GIRAFFE + giraffe_model = giraffe.Giraffe(expression, motif.T, ppi) + + R_hat = giraffe_model.get_regulation() # Size (G, TF) + TFA_hat = giraffe_model.get_tfa() # Size (TF, n) + + LOGGER.warning('Testing Rhat') + Rres = pd.read_csv(r_file, sep="\t", index_col=0) + # check Rres is same size + assert Rres.shape == R_hat.shape + # check values are close + np.testing.assert_allclose(Rres.values, R_hat, atol=1e-5) + + LOGGER.warning('Testing TFAhat') + TFAres = pd.read_csv(tfa_file, sep="\t", index_col=0, header = None) + TFAres = TFAres + # check TFAres is same size + assert TFAres.shape == TFA_hat.shape + # check values are close + np.testing.assert_allclose(TFAres.values, TFA_hat, atol=1e-5) From 2c684939cbf7bd14cb88377114115637f552722c Mon Sep 17 00:00:00 2001 From: katehoffshutta <43797774+katehoffshutta@users.noreply.github.com> Date: Fri, 9 Jan 2026 10:00:56 -0500 Subject: [PATCH 2/4] added informative exception for kappa fitting error + test (#370) --- netZooPy/dragon/dragon.py | 25 ++++++++++++++++++++----- tests/test_dragon.py | 6 ++++++ 2 files changed, 26 insertions(+), 5 deletions(-) diff --git a/netZooPy/dragon/dragon.py b/netZooPy/dragon/dragon.py index 9ade59e0..d8ceedf7 100644 --- a/netZooPy/dragon/dragon.py +++ b/netZooPy/dragon/dragon.py @@ -275,7 +275,10 @@ def estimate_kappa_dragon(n, p1, p2, lambdas, seed, simultaneous = False): Dlogli11 = lambda x: (1./4*p1*(p1-1) *(sc.digamma(x/2)-sc.digamma((x-1)/2)) +term_Dlogli11) - kappa11 = optimize.bisect(Dlogli11, 1.001, 1000*n) + try: + kappa11 = optimize.bisect(Dlogli11, 1.001, 1000*n) + except ValueError: + raise Exception("[dragon.estimate_kappa_dragon] Unable to optimize kappa11, likely due to high p, low n. \n Consider use of dragon.estimate_p_values_mc instead if p is reasonably small (~1000).") else: kappa11 = np.nan @@ -284,7 +287,11 @@ def estimate_kappa_dragon(n, p1, p2, lambdas, seed, simultaneous = False): Dlogli22 = lambda x: (1./4*p2*(p2-1) *(sc.digamma(x/2)-sc.digamma((x-1)/2)) +term_Dlogli22) - kappa22 = optimize.bisect(Dlogli22, 1.001, 1000*n) + try: + kappa22 = optimize.bisect(Dlogli22, 1.001, 1000*n) + except ValueError: + raise Exception("[dragon.estimate_kappa_dragon] Unable to optimize kappa22, likely due to high p, low n. \n Consider use of dragon.estimate_p_values_mc instead if p is reasonably small (~1000)") + else: kappa22 = np.nan @@ -293,7 +300,11 @@ def estimate_kappa_dragon(n, p1, p2, lambdas, seed, simultaneous = False): Dlogli12 = lambda x: (1./2*p1*p2 *(sc.digamma(x/2)-sc.digamma((x-1)/2)) +term_Dlogli12) - kappa12 = optimize.bisect(Dlogli12, 1.001, 1000*n) + try: + kappa12 = optimize.bisect(Dlogli12, 1.001, 1000*n) + except ValueError: + raise Exception("[dragon.estimate_kappa_dragon] Unable to optimize kappa12, likely due to high p, low n. \n Consider use of dragon.estimate_p_values_mc instead if p is reasonably small (~1000)") + else: kappa12 = np.nan @@ -427,8 +438,12 @@ def assign_p_to_r(r_target, r_null, idx1, idx2, verbose=True): if np.min(r_null)<0: return("[netZooPy.dragon.dragon.assign_p_to_r] Error: null distribution must be absoluted before using this function") return np.sum(r_null>np.abs(r_target))/len(r_null) - + + def estimate_p_values_mc(r, n, p1, p2, lambdas, seed = 1, verbose = True): + if(p1 + p2 > 2000): + print("[dragon.estimate_p_values_mc] This function may be prohibitively slow for larger values of p1 + p2. Speed improvements are work in progress. \n Consider thresholding by magnitude instead of p-values.") + lam = lambdas r_null = MC_estimate(n, p1, p2,lam, seed) @@ -496,7 +511,7 @@ def estimate_p_values_mc(r, n, p1, p2, lambdas, seed = 1, verbose = True): # adj_pvalues_mat += adj_pvalues_mat.T return(mc_p) - + def calculate_true_R(X1, X2, Sigma): x = np.arange(0., 1.01, 0.01) n_lams = len(x) diff --git a/tests/test_dragon.py b/tests/test_dragon.py index c81778e0..86302c8a 100644 --- a/tests/test_dragon.py +++ b/tests/test_dragon.py @@ -127,3 +127,9 @@ def test_singularity_exception(): dragon.dragon.get_shrunken_covariance_dragon(X1 = layer1, X2 = layer2, lambdas=[0,0]) # no shrinkage assert(str(exc.value) == "[dragon.dragon.get_shrunken_covariance_dragon] Sigma is not invertible for the input values of lambda. Make sure that you are using `estimate_penalty_parameters_dragon` to select lambda. You may have variables with very small variance or highly collinear variables in your data. Consider removing such variables.") return() + +def test_catch_kappa_error(): + with pytest.raises(Exception) as exc: + dragon.dragon.estimate_kappa_dragon(n=10, p1=1000, p2=1000, lambdas=[0.1,0.1], seed=123, simultaneous = False) + assert(str(exc.value) == "[dragon.estimate_kappa_dragon] Unable to optimize kappa11, likely due to high p, low n. \n Consider use of dragon.estimate_p_values_mc instead if p is reasonably small (~1000).") + return() \ No newline at end of file From 4e4eeca5b4c753e1a3ec31ffbfd1895edaded16a Mon Sep 17 00:00:00 2001 From: violafanfani <35488779+violafanfani@users.noreply.github.com> Date: Fri, 9 Jan 2026 10:11:16 -0500 Subject: [PATCH 3/4] fixing torch issue (#371) * fixing torch issue --- recipe/recipe.yaml | 2 ++ 1 file changed, 2 insertions(+) diff --git a/recipe/recipe.yaml b/recipe/recipe.yaml index e58b2aad..c7b73c93 100644 --- a/recipe/recipe.yaml +++ b/recipe/recipe.yaml @@ -25,6 +25,7 @@ requirements: - click - pandas - pytables + - pytorch run: - python - numpy >=1.19.2 @@ -38,6 +39,7 @@ requirements: - click - pandas - pytables + - pytorch tests: - script: From d7f2201ba741f4e3212bb24b45b1b8a7c4e4a4f6 Mon Sep 17 00:00:00 2001 From: katehoffshutta <43797774+katehoffshutta@users.noreply.github.com> Date: Fri, 9 Jan 2026 13:10:03 -0500 Subject: [PATCH 4/4] =?UTF-8?q?Bump=20version:=200.10.9=20=E2=86=92=200.11?= =?UTF-8?q?.0?= MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit --- .bumpversion.cfg | 2 +- README.md | 2 +- conda/meta.yaml | 2 +- docs/conf.py | 2 +- netZooPy/__init__.py | 2 +- setup.py | 2 +- 6 files changed, 6 insertions(+), 6 deletions(-) diff --git a/.bumpversion.cfg b/.bumpversion.cfg index fcd14433..023442d9 100644 --- a/.bumpversion.cfg +++ b/.bumpversion.cfg @@ -1,5 +1,5 @@ [bumpversion] -current_version = 0.10.9 +current_version = 0.11.0 commit = True [bumpversion:file:setup.py] diff --git a/README.md b/README.md index 71d977aa..8977038d 100644 --- a/README.md +++ b/README.md @@ -108,4 +108,4 @@ Please report any issues to the [issues page](https://github.com/netZoo/netZooPy Please note that this project is released with a [Contributor Code of Conduct](CONDUCT.md). By participating in this project you agree to abide by its terms. -Latest version: 0.10.9 +Latest version: 0.11.0 diff --git a/conda/meta.yaml b/conda/meta.yaml index 26e5980e..448f2d17 100644 --- a/conda/meta.yaml +++ b/conda/meta.yaml @@ -1,6 +1,6 @@ package: name: netzoopy - version: 0.10.9 + version: 0.11.0 source: path: .. diff --git a/docs/conf.py b/docs/conf.py index dceaf5d8..9ffca205 100644 --- a/docs/conf.py +++ b/docs/conf.py @@ -29,7 +29,7 @@ author = u'netZoo' # The short X.Y version -__version__ = "0.10.9" +__version__ = "0.11.0" version = ".".join(__version__.split(".")[:2]) # The full version, including alpha/beta/rc tags release = __version__ diff --git a/netZooPy/__init__.py b/netZooPy/__init__.py index 6a2c58aa..bb0f8197 100644 --- a/netZooPy/__init__.py +++ b/netZooPy/__init__.py @@ -8,4 +8,4 @@ from netZooPy import sambar from netZooPy import bonobo -__version__ = "0.10.9" +__version__ = "0.11.0" diff --git a/setup.py b/setup.py index c9f5c08f..7bad036c 100755 --- a/setup.py +++ b/setup.py @@ -1,7 +1,7 @@ from setuptools import setup, find_packages setup(name='netZooPy', - version='0.10.9', + version='0.11.0', description='Python implementation of netZoo', url='https://github.com/netZoo/netZooPy', author='netZoo team',