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As detailed in the documentation, handling dense structures can be computationally burdensome. Essentially, an increase in the number of nodes may introduce complexities due to the cubic growth of the distance matrix size.
I particularly had a feature request, which might very well be already available but not explained in the documentation. I was wondering if brainsmash can also accept scipy.sparse distance matrices (or possibly inverses of distance such that zero would denote very long distances). This would result in a potentially considerable computational speedup and also reduce storage requirements for the dense distance matrix.
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