The excessive number of mutations leads to a slow execution speed

When the number of mutations in my ssm_data.txt file exceeds ten thousand, the execution speed of Phylowgs becomes extremely slow. I would like to know if the results obtained by constructing 3500 trees using a single MCMC chain are equally reliable compared to the results obtained by constructing 3500 trees using ten MCMC chains together.

In other words, are the reliability of the results obtained through the following two approaches the same:

Approach 1:
python2 multievolve.py --num-chains 1 --ssms ssm_data.txt --cnvs cnv_data.txt --burnin-samples 1000 --mcmc-samples 2500

Approach 2:
python2 multievolve.py --num-chains 10 --ssms ssm_data.txt --cnvs cnv_data.txt --burnin-samples 100 --mcmc-samples 250