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Enhanced sampling molecular dynamics on HPC systems

Instructor/Author

Dr. Michael Shirts

Author

Wei-Tse Hsu

Videos

TBD

Outline

Here is the outline of this session, which alternatives between lecture sections and hands-on exercises:

  • Introduction to High-Performing Computing (HPC) systems
  • Exercise 1: Performing decoupled MD simulations in parallel
  • Introduction to multiple walkers metadynamics
  • Exercise 2: Multiple walker metadynamics]
  • Introduction to umbrella sampling
  • Exercise 3: Umbrella sampling
  • Constructing biases from simulations
  • Exercise 4: Replica exchange umbrella sampling
  • Introduction to temperature and Hamiltonian replica exchange
  • Exercise 5: Alchemical replica exchange
  • Introduction to other replica exchange methods and hybrid methods